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  • 1.
    Andersson, Hanna
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Organic Chemistry.
    Carlsson, Anna-Carin C.
    University of Gothenburg, Gothenburg, Sweden.
    Nekoueishahraki, Bijan
    University of Gothenburg, Gothenburg, Sweden.
    Brath, Ulrika
    University of Gothenburg, Gothenburg, Sweden.
    Erdélyi, Máté
    University of Gothenburg, Gothenburg, Sweden.
    Chapter Two - Solvent Effects on Nitrogen Chemical Shifts2015In: Annual Reports on NMR Spectroscopy, Academic Press , 2015, Vol. 86, p. 73-210Chapter in book (Other academic)
    Abstract [en]

    Due to significant developments in cryogenic probe technology and the easy access to inverse detection pulse programmes (HSQC, HMBC), the sensitivity of nitrogen NMR has lately vastly improved. As a consequence, nitrogen NMR has turned into a useful and commonly available tool for solution studies of molecular structure and properties for small organic compounds likewise biopolymers. The high sensitivity of the nitrogen lone pair to changes in the molecular environment, alterations in intra- and intermolecular interactions, and in molecular conformation along with its wide, up to 1200ppm chemical shift dispersion make nitrogen NMR to an exceptionally sensitive reporter tool. The nitrogen chemical shift has been applied in various fields of chemistry, including for instance the studies of transition metal complexes, chemical reactions such as N-alkylation and N-oxidation, tautomerization, protonation–deprotonation equilibria, hydrogen and halogen bonding, and elucidation of molecular conformation and configuration. The 15N NMR data observed in the investigation of these molecular properties and processes is influenced by the medium it is acquired in. This influence may be due to direct coordination of solvent molecules to transition metal complexes, alteration of tautomerization equilibria, and solvent polarity induced electron density changes of conjugated systems, for example. Thus, the solvent may significantly alter the observed nitrogen NMR shifts. This review aims to provide an overview of solvent effects of practical importance, and discusses selected experimental reports from various subfields of chemistry.

  • 2.
    Andersson, Pher
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Bäckvall, Jan-E.
    Synthesis of Heterocyclic Natural Products via Regio- and Stereocontrolled Palladium-Catalyzed Reactions1996In: Advances in Heterocyclic Natural Product Synthesis, JAI Press Inc, Greenwich , 1996, p. 179-215Chapter in book (Refereed)
  • 3.
    Antoni, Gunnar
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Kihlberg, T.
    Långström, B.
    11C: Labelling chemistry and labelled compounds2003In: Handbook Chem03_0302, 2003, no 332, p. 119-165Chapter in book (Refereed)
  • 4.
    Baltzer, Lars
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry and Organic Chemistry. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Klinman, J.P.
    Hynes, J.T.
    Limbach, H-H.
    Acid base catalysis in designed polypeptides2006In: Handbook of Hydrogen Transfer, Wiley , 2006Chapter in book (Refereed)
  • 5. Bradley, Jean-Claude
    et al.
    Guha, Rajarshi
    Lang, Andrew
    Lindenbaum, Pierre
    Neylon, Cameron
    Williams, Antony
    Willighagen, Egon
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Beautifying Data in the Real World2009In: Beautiful Data: The Stories Behind Elegant Data Solutions / [ed] Toby Segaran & Jeff Hammerbacher, Sebastol, USA: O'Reilly , 2009, 1, p. 259-278Chapter in book (Other (popular science, discussion, etc.))
  • 6.
    Gising, Johan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Larhed, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Molecular Imaging.
    Odell, Luke R
    University of Newcastle, Australia.
    Microwave-assisted synthesis of anti-tuberculosis, HIV and hepatitis C agents2014In: Microwaves in Drug Discovery and Development: Recent Advances, Future Medicine , 2014, p. 34-54Chapter in book (Refereed)
    Abstract [en]

    Microwave heating technology is ideally suited to small-scale discovery chemistry applications, as it allows for full reaction control, rapid (super)heating, short reaction times, high safety and rapid feedback. These unique properties offer unparalleled opportunities for medicinal chemists to speed up the lead optimization process in early drug discovery. To illustrate these advantages, we herein describe a number of recent applications of dedicated microwave instrumentation in the synthesis of small molecules targeting three of the most prevalent infectious diseases: tuberculosis, HIV/AIDS and hepatitis C.

  • 7.
    Klunk, W.E.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Engler,
    H. Nordberg, A.
    Bacskai, B.
    Wang, Y.
    Price, J.
    Bergström, M.
    Hyman, B.
    Långström, B.
    Mathis, C.A.
    Imaging the Pathology of Alzheimer's Disease: Amyloid-Imaging with PET2003In: Neuroimaging Clinics, 2003, no 435Chapter in book (Refereed)
  • 8.
    Matsson, Olle
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry and Organic Chemistry. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Isotope Effects for Exotic Nuclei2006In: Isotope Effects in Chemistry and Biology, CRC Press, Taylor & Francis Group, NW , 2006, p. 417-431Chapter in book (Refereed)
  • 9.
    Miller, Philip W.
    et al.
    Department of Chemistry, Imperial College London, London, UK.
    Kato, Koichi
    Department of Molecular Imaging, National Centre of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
    Långstrom, Bengt
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Physical Organic Chemistry.
    Carbon-11, Nitrogen-13, and Oxygen-15 Chemistry: An Introduction to Chemistry with Short-Lived Radioisotopes2015In: The Chemistry of Molecular Imaging / [ed] Nicholas Long and Wing-Tak Wong, Wiley-Blackwell, 2015, p. 79-103Chapter in book (Refereed)
    Abstract [en]

    This chapter first introduces the field of carbon-11, nitrogen-13, and oxygen-15 chemistry, and then provides an up-to-date account of their chemistry. The carbon-11 isotope is most widely produced by the proton bombardment of nitrogen-14 in a gas phase cyclotron target. 11CO2 is the most widely produced in target C-11 primary precursor. Methylation reactions are commonly used for the production of many of the key 11C-tracers. Palladium-mediated C-11 carbonylation reactions are most widely exploited and used to effectively label imides, ketones, carboxylic acids, esters, amides, and acrylamides. N-13 labelled amines are of interest for improving positron emission tomography (PET) myocardial perfusion imaging and representing their metabolism. Oxygen-15 is generally produced in target via the bombardment of nitrogen gas with deuterons. The majority of O-15 chemistry is therefore based on the production of small molecules either directly within the cyclotron target or via one chemical transformation using high temperature gas phase methods.

  • 10.
    Nicholls, Ian A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC. Linnaeus Univ, Bioorgan & Biophys Chem Lab, Ctr Biomat Chem, Dept Chem & Biomed, S-39182 Kalmar, Sweden..
    Chavan, Swapnil
    Linnaeus Univ, Bioorgan & Biophys Chem Lab, Ctr Biomat Chem, Dept Chem & Biomed, S-39182 Kalmar, Sweden..
    Golker, Kerstin
    Linnaeus Univ, Bioorgan & Biophys Chem Lab, Ctr Biomat Chem, Dept Chem & Biomed, S-39182 Kalmar, Sweden..
    Karlsson, Björn C. G.
    Linnaeus Univ, Bioorgan & Biophys Chem Lab, Ctr Biomat Chem, Dept Chem & Biomed, S-39182 Kalmar, Sweden..
    Olsson, Gustaf D.
    Linnaeus Univ, Bioorgan & Biophys Chem Lab, Ctr Biomat Chem, Dept Chem & Biomed, S-39182 Kalmar, Sweden..
    Rosengren, Annika M.
    Linnaeus Univ, Bioorgan & Biophys Chem Lab, Ctr Biomat Chem, Dept Chem & Biomed, S-39182 Kalmar, Sweden..
    Suriyanarayanan, Subramanian
    Linnaeus Univ, Bioorgan & Biophys Chem Lab, Ctr Biomat Chem, Dept Chem & Biomed, S-39182 Kalmar, Sweden..
    Wiklander, Jesper G.
    Linnaeus Univ, Bioorgan & Biophys Chem Lab, Ctr Biomat Chem, Dept Chem & Biomed, S-39182 Kalmar, Sweden..
    Theoretical and Computational Strategies for the Study of the Molecular Imprinting Process and Polymer Performance2015In: Molecularly Imprinted Polymers In Biotechnology, Cham, Switzerland: Springer, 2015, p. 25-50Chapter in book (Refereed)
    Abstract [en]

    The development of in silico strategies for the study of the molecular imprinting process and the properties of molecularly imprinted materials has been driven by a growing awareness of the inherent complexity of these systems and even by an increased awareness of the potential of these materials for use in a range of application areas. Here we highlight the development of theoretical and computational strategies that are contributing to an improved understanding of the mechanisms underlying molecularly imprinted material synthesis and performance, and even their rational design.

  • 11. Odell, L. R.
    et al.
    Sävmarker, J.
    Lindh, J.
    Nilsson, P.
    Larhed, M.
    7.18 Addition Reactions with Formation of Carbon–Carbon Bonds: (v) The Oxidative Heck Reaction2014In: Comprehensive Organic Synthesis II (Second Edition), Amsterdam: Elsevier, 2014, p. 492-537Chapter in book (Refereed)
    Abstract [en]

    Abstract The Heck reaction, generally defined as the substitution of a vinylic hydrogen with an aryl, vinyl, or benzyl group, is widely regarded as one of the premier synthetic tools for the construction of new C–C bonds. The oxidative Heck reaction, which commences with the generation of the key arylpalladium species under palladium(II) catalysis, has emerged as a powerful alternative to the palladium(0)-catalyzed Mizoroki−Heck reaction over the past decade. This chapter gives an overview of the various olefin and aryl/vinyl substrate classes that have been utilized in this reaction. The material is organized according to the reaction type (inter- or intramolecular), the electronic nature of the olefin (electron-poor, electron-rich, or neutral), and the olefin coupling partner. Special emphasis is given to some of the more recent advances in this area and, where applicable, a critical review of the most synthetically useful methods is presented.

  • 12.
    Ottosson, H
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Guliashvili, T
    El-Sayed, I.
    Thermolytic Formation and Trapping of Silenes Strongly Influenced by Reversed Polarization2003In: Organosilicon Chemostry V - From Molecules to Materials, Wiley-VCH , 2003, p. 78-81Chapter in book (Other scientific)
  • 13.
    Russo, Francesco
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Odell, Luke R
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Olofsson, Kristofer
    Nilsson, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Larhed, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Microwave-Heated Transition Metal-Catalyzed Coupling Reactions2012In: Microwaves in Organic Synthesis / [ed] de la Hoz, A, Loupy, A, Weinheim: Wiley-VCH Verlagsgesellschaft, 2012, 3, p. 607-672Chapter in book (Refereed)
  • 14.
    Sivaev, I.B
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Sjöberg, S
    Bregadze, V.I.
    The Synthesis of Functional Derivatives of the [1-CB9H10]- Anion for Boron Neutron Capture Therapy2003In: Boron Chemistry at the Beginning of the 21st Century. Y.N Bubnov, (ed), Editoral URSS, Scientific Literature and Textbooks , 2003, p. 333-337Chapter in book (Refereed)
  • 15.
    Tolmachev, V.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Bruskin, A.
    Orlova, A.
    Winberg, K.J.
    Sivaevv, I.B.
    Nestor, M., Lundqvist, H.
    Sjöberg, S.
    Radiohalogenated Polyhedral Borate Anaions for use in Targeted Oncological Radionuclide Therapy, Some Recent Developments2003In: Boron Chemistry at the Beginning of the 21st Century. Y.N Bubnov, Editoral URSS, Scientific Literature and Textbooks,, Moscow , 2003, p. 338-3342Chapter in book (Other academic)
  • 16.
    Trejos, Alejandro
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Odell, Luke R
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Alkenes with Metal-Directing Groups as Reaction Components2013In: Science of Synthesis: Cross-Coupling and Heck-Type Reactions, Volume 3, Metal-Catalyzed Heck-Type Reactions and C-C Cross Coupling via C–H Activation / [ed] Mats Larhed, Stuttgart: Georg Thieme Verlag KG, 2013, p. 345-390Chapter in book (Refereed)
1 - 16 of 16
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