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  • 1001.
    Winberg, Karl Johan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Barbera, Gemma
    Eriksson, Ludvig
    Texidor, Francesc
    Tolmachev, Vladimir
    Viñas, Clara
    Sjöberg, Stefan
    High yield [125I]-labelling of iodinated carboranes by palladium-catalysed isotopic exchange2003In: Journal of Organometallic Chemistry, Vol. 680, p. 182-192Article in journal (Refereed)
  • 1002.
    Winberg, Karl Johan
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Barberà, G
    Eriksson, Ludvig
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Teixidor, F
    Tolmachev, Vladimir
    Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Viñas, C
    Sjöberg, Stefan
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    High yield [125 I]Iodide-Labeling of Iodinated Carboranes By Palldium-Catalyzed Isotopic Exchange2003In: Journal of Organometallic Chemistry, no 680, p. 188-192Article in journal (Refereed)
  • 1003.
    Winberg, Karl Johan
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Mume, Eskender
    Martinez, Olga M.
    Danflous, Stephane
    Calsson, Tobias
    Synthesis of some novel boronated acridine compounds for possible use in BNCT.Manuscript (Other academic)
  • 1004.
    Winberg, Karl Johan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Mume, Eskender
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Sjöberg, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Radiobromination of closo-carboranes using palladium-catalyzed halogen exchange2005In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 48, no 3, p. 195-202Article in journal (Refereed)
  • 1005.
    Winberg, Karl Johan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Persson, Mikael
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
    Malmström, Per-Uno
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Sjöberg, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    Radiobromination of anti-HER2/neu/ErbB-2 monoclonal antibody using the p-isothiocyanatobenzene derivative of the [76Br]undecahydro-bromo-7,8-dicarba-nido-undecaborate(1-) ion2004In: Nuclear Medicine and Biology, ISSN 0969-8051, E-ISSN 1872-9614, Vol. 31, no 4, p. 425-33Article in journal (Refereed)
    Abstract [en]

    The monoclonal humanized anti-HER2 antibody trastuzumab was radiolabeled with the positron emitter (76)Br (T(1/2) =16.2 h). Indirect labeling was performed using the p-isothiocyanatobenzene derivative of the [(76)Br]undecahydro-bromo-7,8-dicarba-nido-undecaborate(1-) ((76)Br-NBI) as a precursor molecule. (76)Br-NBI was prepared by bromination of the 7-(p-isothiocyanato-phenyl)dodecahydro-7,8-dicarba-nido-undecaborate(1-) ion (NBI) with a yield of 93-95% using Chloramine-T (CAT) as an oxidant. Coupling of radiobrominated NBI to antibody was performed without intermediate purification, in an "one pot" reaction. An overall labeling yield of 55.7 +/- 4.8% (mean +/- maximum error) was achieved when 300 microg of antibody was labeled. The label was stable in vitro in physiological and denaturing conditions. In a cell binding test, trastuzumab remained immunoreactive after labeling.

  • 1006.
    Winberg, Karl Johan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Persson, Mikael
    Tolmachev, Vladimir
    Sjöberg, Stefan
    Radio-bromination of anti-HER2/neu/erbB-2 monoclonal antibody using p-isothiocyanatobenzene derivative of the [76Br]undecahydro-bromo-7,8-dicarba-nido-undecaborate(1-).In: Article in journal (Refereed)
  • 1007.
    Winberg, Karl Johan
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Toom, Lauri
    Sjöberg, Stefan
    Synthesis of boronated acridine carboxylic acid as a possible agent for BNCT.Manuscript (Other academic)
  • 1008.
    Winberg K.J, Barbera G, Eriksson L, Teixidor F, Tolmachev V, Viñas C, Sjöbeg S.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    High yield [125I]Iodide-Labelling of Iodinated Carboranes By Palladium-Catalyzed Isotopic Exchange2003In: Journal of Organometallic Chemistry, no 680, p. 188-192Article in journal (Refereed)
  • 1009.
    Wirde, M
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics.
    Gelius, U
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics.
    Nyholm, L
    Chemistry, Department of Chemistry.
    Self-assembled monolayers of cystamine and cysteamine on gold studied by XPS and voltammetry1999In: LANGMUIR, ISSN 0743-7463, Vol. 15, no 19, p. 6370-6378Article in journal (Refereed)
    Abstract [en]

    The formation of self-assembled chemisorbed layers of cystamine, cysteamine, and 4-aminothiophenol on gold has been studied by XPS and voltammetry. These compounds, often used in the preparation of biosensors and modified electrodes, are shown to yield surface coverages of approximately 80% of that of a octadecanethiol monolayer within 5 min in millimolar aqueous and ethanolic solutions. The results of the XPS experiments reveal that a shoulder on the S 2p(3/2) peak (situated at 162.1 eV) develops at 161.3 eV upon increasing the adsorption time from minutes to 1 week and that the initial rate of formation of the shoulder is higher for cystamine than for cysteamine. This shoulder is believed to be due to the presence of a sulfur species with a higher coordination number with respect to gold. Increased adsorption times also give rise to increased amounts of oxidized carbon and sulfur in the films. The oxidation of the sulfur in the thiols results in a detachment of the molecules from the gold surface, as indicated by XPS experiments with different takeoff angles. The main N 1s peak for cystamine is shifted toward higher binding energies for increasing adsorption times while two prominent nitrogen peaks are generally seen for cysteamine. For cysteamine, increasing adsorption times result in an increase of the main nitrogen component at the higher binding energy, yielding an apparent shift in the nitrogen peak with time similar to that seen for cystamine. Possible explanations for these experimental findings are discussed. Cystamine, cysteamine, and 4-aminothiophenol films on gold are shown to be irreversibly oxidized in the gold oxide formation region. On the basis of evaluation of the oxidation charge, surface coverages of approximately 1 x 10(-9) mol/cm(2) were obtained for adsorption times between 5 min and 1 week.

  • 1010. WOJCIK, MAREK J
    et al.
    HERMANSSON, KERSTI
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    LINDGREN, JAN
    OJAMAE, LARS
    THEORETICAL SIMULATION OF OH AND OD STRETCHING BANDS OF ISOTOPICALLY DILUTED HDO MOLECULES IN AQUEOUS-SOLUTION1993In: Chemical Physics, ISSN 0301-0104, E-ISSN 1873-4421, Vol. 171, no 1-2, p. 189-201Article in journal (Refereed)
    Abstract [en]

    Uncoupled OH and OD stretching bands of HDO molecules have been calculated for an ionic aqueous solution, based on the trajectories from a classical statistical-mechanical computer simulation and subsequent quantum-mechanical calculations of the vibrational energy levels. Each V(r(OH)) potential function has been constructed as a sum of intra- and intermolecular energies, where different intermolecular water-water potential functions from the literature (MCY, TIPS2, RWK2 and CF2) have been tested in conjunction with the experimentally derived HMS intramolecular potential. In this way, vibrational densities-of-states as well as infrared absorption bands have been calculated for HDO molecules in the bulk and in the ionic hydration shells (Li+, HCOO-). Calculated frequencies and band widths for the TIPS2 and MCY potentials are fairly close to experimental values. The calculated OH shift between the gas and liquid water phases is - 303 cm-1 with the TIPS2 potential, as compared to the experimental value of - 307 cm-1. The MCY potential gives - 260 cm-1, while RWK2 as well as the CF2 potentials give rise to a non-negligible number of spurious frequencies. Water molecules in the first hydration shell of Li+ exhibit only slightly lower stretching frequencies than bulk water. The frequencies of the OH and OD groups of HDO molecules bonded to the formate oxygen atoms are lower than in bulk water, while the frequency of the OH/OD group pointing away from the formate ion is higher compared to bulk water.

  • 1011. Wojcik, Mark C.
    et al.
    Hermansson, Kersti
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    COMPUTER MODELING OF LITHIUM FORMATE MONOHYDRATE1987In: ACTA CHEM SCAND A, ISSN 0302-4377, Vol. 41, no 10, p. 562-572Article in journal (Refereed)
  • 1012. Wolpher, H.
    et al.
    Huang, P.
    Borgström, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical Chemistry.
    Bergquist, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Styring, S.
    Sun, L.C.
    Åkermark, B.
    Synthesis of a Ru(bpy)(3)-type complex linked to a free terpyridine ligand and its use for preparation of polynuclear bimetallic complexes2004In: Catalysis Today, ISSN 0920-5861, E-ISSN 1873-4308, Vol. 98, no 4, p. 529-536Article in journal (Refereed)
    Abstract [en]

    A terpyridine ligand has been covalently linked to a Ru(bpy)3 complex via an amide bond. By using this functionalized terpyridine ligand, a series of multinuclear bimetallic complexes have been synthesized and characterized. One of these complexes has the structure of di-μ-oxo-bridged Mn dimer. EPR spectra of this complex showed that, depending on the procedure for the preparation, the oxidation states of the Mn dimer is either a Mn2III,IV dimer or a mixture of this and Mn2IV,IV dimer. Water oxidation catalyzed by this complex has been performed.

  • 1013. Wolpher, Henriett
    et al.
    Huang, Ping
    Borgström, Magnus
    Bergquist, Jonas
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Analytisk kemi.
    Styring, Stenbjörn
    Sun, Licheng
    Åkermark, Björn
    Synthesis of a Ru(bpy)3-type complex linked to a free terpyridine ligand and its use for preparation of polynuclear bimetallic complexes2004In: Catalysis Today, no 98, p. 529-536Article in journal (Refereed)
    Abstract [en]

    A terpyridine ligand has been covalently linked to a Ru(bpy)3 complex via an amide bond. By using this functionalized terpyridine ligand, a series of multinuclear bimetallic complexes have been synthesized and characterized. One of these complexes has the structure of di-u-oxo-bridged Mn dimer. EPR spectra of this complex showed that, depending on the procedure for the preparation, the oxidation states of the Mn dimer is either a Mn2 III,IV dimer or a mixture of this and Mn2 IV,IV dimer. Water oxidation catalyzed by this complex has been performed.

  • 1014.
    Wolpher, Henriette
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical Chemistry.
    Borgström, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Hammarström, Leif
    Bergquist, Jonas
    Sundström, Villy
    Styring, Stenbjörn
    Sun, Lichen
    Åkermark, Björn
    Synthesis and properties of an iron hydrogenase active site model linked to a ruthenium tris-bipyridine photosensitizer2003In: Inorganic Chemistry Communications, Vol. 6, p. 989-991Article in journal (Refereed)
  • 1015.
    Wu, F
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Orlefors, H
    Bergström, M
    Antoni, Gunnar
    Omura, H
    Watanbe, Y
    Eriksson, B
    Långström, B
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
    Uptake of 14-C and 11C-labeled glutamate, glutamine and aspartate in vitro and in vivo.2000In: Anticancer Res.Article in journal (Other academic)
  • 1016.
    Wu, F
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Yngve, U
    Hedberg, E
    Honda, M
    Lu, L
    Eriksson, B
    Watanabe, Y
    Bergström, M
    Långström, B
    Department of Biochemistry and Organic Chemistry.
    Distribution of 76Br-labeled antisense oligonucleotides of different length determined ex vivo in rats2000In: Eur. J. Pharm. Sci.Article in journal (Other scientific)
  • 1017.
    Wu, Shiaw-Lin
    et al.
    ThermoFinnigan, California.
    Choudhary, Gargi
    ThermoFinnigan, California.
    Ramström, Margareta
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Bergquist, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Hancock, William S.
    Barnett Institute, and Department of Chemistry, Northeastern University.
    Evaluation of Shotgun Sequencing for Proteomic Analysis of Human Plasma Using HPLC Coupled with Either Ion Trap or Fourier Transform Mass Spectrometry2003In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 2, no 4, p. 283-293Article in journal (Refereed)
    Abstract [en]

    This paper reports on studies directed to the characterization of the proteome of human plasma by the shotgun sequencing approach, namely the use of HPLC coupled to mass spectrometry (MS). The report will present data from two laboratories that allows the comparison of peptide and protein identifications by either accurate mass measurement on a Fourier transform mass spectrometry or MS/MS fragmentation on an ion trap mass spectrometer. Because the dynamic range of the protein components of plasma is one of the largest for a biological sample, the analysis of such a challenging sample was aided by the use of these two MS approaches. The major classes of proteins observed were transport proteins, enzymes, and enzyme inhibitors, blood-clotting factors, membrane-associated proteins including soluble forms of receptors, hormones, immunoglobulins, and other glycoproteins. The protein identifications were also highly consistent with results obtained from 2D gel studies, although a larger number of additional proteins were observed with the shotgun sequencing approach. The quantitation of low to medium level proteins was explored in the ion trap with an add-back of a known amount of human growth hormone (hGH) at a clinically relevant level (5 ug/L). The isotope coded affinity tag (ICAT) approach was used to quantitate successfully different levels of hGH in replicate analysis via the disulfide linked tryptic peptide (T6-T16). These studies suggest that the shotgun sequencing approach can be used to characterize part of the plasma proteome and serve as a starting point for the use of multidimensional analytical approaches for the analysis of complex biological samples.

  • 1018.
    Wu, S-L.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Choudhary, G.
    Ramström, M.
    Bergquist, J.
    Hancock, W.S.
    Evaluation of shotgun sequencing for proteomic analysis of human plasma using HPLC coupled with either ion trap or fourier transform mass spectrometry2003In: J. Proteome Res., no 2, p. 383-393Article in journal (Refereed)
  • 1019. Wållberg, Maja
    et al.
    Bergquist, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Achour, Adnane
    Breij, Esther
    Harris, Robert A.
    Malondialdehyde modification of myelin oligodendrocyte glycoprotein leads to increased immunogenicity and encephalitogenicity2007In: European Journal of Immunology, ISSN 0014-2980, E-ISSN 1521-4141, Vol. 37, no 7, p. 1986-1995Article in journal (Refereed)
    Abstract [en]

    Self proteins may become autoantigenic through structural modification. We studied malondialdehydation of recombinant rat (rr) myelin oligodendrocyte glycoprotein (MOG), an autoantigen in multiple sclerosis. Malondialdehyde (MDA) modification changed protein weight and charge, the location of these adducts being mapped by Fourier transform ion cyclotron resonance. Molecular modelling revealed significant differences in the MDA-rrMOG three-dimensional structure. DBA/1 mice immunised with MDA-rrMOG developed greater proliferative responses and more severe experimental autoimmune encephalomyelitis than mice immunised with unmodified rrMOG. MDA-rrMOG was taken up more effectively by antigen-presenting cells (APC), at least partially through scavenger receptors. Exposure to MDA-rrMOG led to increased expression of IL-23, IL-12 and IL-12R, indicating a role not only for increased antigen uptake but also for activation of APC. We thus provide biochemical, structural, immunological and clinical data that suggest that the post-translationally modified form of this myelin autoantigen is a more relevant form of the molecule.

  • 1020.
    Xiaoguang, Luo
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Determination of Total Mercury in Natural Waters and Studies of Some Selenium Reactions of Analytical Relevance1996Licentiate thesis, monograph (Other academic)
  • 1021.
    Xing, T
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Wu, F
    Brodin, O
    Fasth, K-J
    Långström, B
    Department of Biochemistry and Organic Chemistry.
    Bergström, M
    In vitro PET evaluations in lung cancer cell lines2000In: Anticancer Res.Article in journal (Other scientific)
  • 1022.
    Yan J, Naeslund C, Al-Madhoun A.S, Wang J, Ji W, Cosquer G.Y, Johnsamuel J, Sjöberg S, Eriksson S, Tjarks W
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Synthesis and Biological Evaluation of 3'-Carboranyl Thymidine Analogues2002In: Biorg Med Chem Lett, no 12, p. 2209-2212Article in journal (Other scientific)
  • 1023. Yanagisawa, Masaru
    et al.
    Korodi, Ferenc
    Bergquist, Jonas
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Physical and Analytical Chemistry, Physical Chemistry. Analytical Chemistry. Analytisk kemi.
    Holmberg, Anna
    Hagfeldt, Anders
    Department of Physical Chemistry. Department of Physical and Analytical Chemistry, Physical Chemistry. Analytical Chemistry.
    Åkermark, Björn
    Sun, Licheng
    Synthesis of phthalocyanines with two carboxylic acid groups and their utilization in solar cells based on nano-structured TiO22004In: Journal of Porphyrins and Phthalocyanines, Vol. 8, no 10, p. 1228-1235Article in journal (Refereed)
  • 1024.
    Yngve, Ulrika
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Labelling of various macromolecules using positron emitting 76Br and 68Ga: Synthesis and characterisation2001Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Different prosthetic groups containing a trialkylstannyl- and an electrophilic group have been synthesised and labelled with the accelerator produced 76Br (T1/2=16 h) through oxidative bromination. The labelled prosthetic groups were conjugated to amino-containing macromolecules such as proteins and 5´-modified oligonucleotides.

    N-Succinimidyl 4-[76Br]bromobenzoate 14 was synthesised in 65 % radio-chemical yield and was conjugated to 5´-hexylamino-modified phosphodiester and phosphorothioate oligonucleotides in 12-19 % isolated radiochemical yield. The stability of the 76Br-oligonucleotide-conjugates in vivo in rats was investigated. No degradation from the 5´-end, resulting in labelled, low molecular weight compounds was detected. Compound 14 has also been used for labelling of different proteins in 23-61% radiochemical yield.

    N-Succinimidyl-5-[76Br]bromo-3-pyridinecarboxylate 17 and methyl-4-[76Br]bromo-benzimidate 15 were synthesised from the corresponding trimethylstannyl-compound in 25% and 40 % yield respectively. Compounds 14 and 17 were conjugated to ε-Boc-octreotide in 55 and 50% isolated radiochemical yield respectively after microwave heating. Compound 15 did not react with octreotide under the conditions investigated. The two 76Br-labelled octreotide derivatives showed different lipophilicity and different binding-properties to tissue from meningiomas.

    Hyaluronic acid, a polysaccharide, was modified with tyramine and labelled by oxidative bromination using 76Br in 10% radiochemical yield.

    The generator produced 68Ga (T1/2=68 min) was used to label octreotide and oligonucleotides modified with the metal chelating group 1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraacetic acid (DOTA). 68Ga-DOTA-octreotide was isolated in 65% radiochemical yield and a phosphorothioated 68Ga-DOTA-oligonucleotide was isolated in 35% radio-chemical yield after 30 min synthesis time.

    Compound 14 was reacted with 3-aminomethylbenzylamine to give compound 18. The specific radioactivity of 18 was determined to be 36 GBq/µmol by measuring the ratio between the mass-peaks for the 76Br and 79Br-compounds using packed-capillary LC-MS.

  • 1025.
    Younis, YMH
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Ghirmay, S
    Al-Shihry, SS
    African Cucurbita pepo L.: properties of seed and variability in fatty acid composition of seed oil2000In: PHYTOCHEMISTRY, ISSN 0031-9422, Vol. 54, no 1, p. 71-75Article in journal (Refereed)
    Abstract [en]

    Pumpkin (Cucurbita pepo) seeds are used locally in Eritrea to treat tapeworm. Seeds were found to be rich in oil (similar to 35%), protein (38%), alpha-tocoferols (3 mg/100 g) and carbohydrate content (similar to 37%). The physico-chemical properties and

  • 1026.
    YUN, H
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    LEE, ML
    MARKIDES, KE
    CHARCOAL POROUS LAYER OPEN-TUBULAR COLUMN GAS-CHROMATOGRAPHY FOR PERMANENT GAS-ANALYSIS1995In: JOURNAL OF MICROCOLUMN SEPARATIONS, ISSN 1040-7685, Vol. 7, no 3, p. 207-212Article in journal (Refereed)
    Abstract [en]

    The preparation of charcoal porous layer open tabular (PLOT) columns, and their application to the separation of permanent gases and light hydrocarbons are reported. Two types of charcoal, coconut and darco charcoal, were used to prepare columns from fus

  • 1027. Zatsepin, D.A.
    et al.
    Galakhov, V.R.
    Gizhevskii, B.A.
    Kurmaev, E.Z.
    Fedorenko, V.V.
    Samokhvalov, A.A.
    Berger, Rolf
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Oorganisk kemi.
    SOFT-X-RAY EMISSION STUDY OF THE INFLUENCE OF LI+ DOPING, IRRADIATION AND PLASTIC DEFORMATION ON CUO1999In: Phys Rev.B, Vol. 59, no 1, p. 211-214Article in journal (Refereed)
    Abstract [en]

    The influence of Li+ doping, shear under pressure, and irradiation with He+ or electrons on the oxygen 2p-band and valence states of copper ions in CuO was studied using soft-X-ray emission spectroscopy. The doping with lithium leads to the appearance of copper ions with formal valency of 3+.

  • 1028. Zatsepin, D.A.
    et al.
    Galakhov, V.R.
    Korotin, M.A.
    Fedorenko, V.V.
    Kurmaev, E.Z.
    Bartkowski, S
    Neumann, M
    Berger, R
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Oorganisk kemi.
    Valence states of copper ions and electronic structure of LiCu2O21998In: Phys Rev B, Vol. 57, no 8, p. 4377-4381Article in journal (Refereed)
    Abstract [en]

    The electronic structure of LiCu2O2 was studied using x-ray emission and photoelectron spectroscopy (valence band and core levels) as well as band-structure calculations in terms of LSDA and LSDA+U approaches. According to the x-ray emission and photoelectron spectra the valence states of the Cu atoms are found to be mixed, i.e. 2+ and 1+.

  • 1029.
    Zeng X., Thibblin A.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Competing base-promoted E2 and E1 reactions of an acidic tertiary substrate2002In: J. Chem. Soc., Perkin Trans 2, p. 1352-Article in journal (Refereed)
  • 1030.
    Zeng, XF
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Thibblin, A
    Competing solvolytic elimination and substitution reactions via very short-lived ion-pair intermediates2001In: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, ISSN 1472-779X, no 9, p. 1600-1607Article in journal (Refereed)
    Abstract [en]

    The solvolysis of 9-methyl-9-(2-X-2-propyl)fluorene (X = Cl, Br, or OOCCF3) (1-X) in aqueous acetonitrile or aqueous 1,1,1-trifluoroethanol (TFE) yields the alkene, 9-methyl-9-(propen-2-yl)fluorene (2), and the alcohol, 9-methyl-9-(2-hydroxy-2-propyl)fluo

  • 1031.
    Zeng, Xiaofeng
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Mechanisms for Solvolytic Elimination and Substitution Reactions Involving Short-lived Carbocation Intermediates2002Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Solvolysis reactions of a range of tertiary substrates in largely aqueous solvents were studied in such respects as β-deuterium kinetic isotope effects, linear free energy relationships and stereochemistry.

    Solvolysis of the fluorene derivatives 9-methyl–9-(2´-X-2´-propyl)fluorene (1-X, X = Cl, Br, OOCCF3) involves a very short-lived carbocation intermediate. The fraction of alkene is increased by addition of general bases, which can be expressed by a Brφnsted parameter β = 0.07. The kinetic deuterium isotope effects vary with solvent composition in a way which is not consistent with a common carbocation intermediate which has time to choose between dehydronation and addition of a solvent water molecule.

    In the absence of bases, the reaction of 4-chloro-4-(4´-nitrophenyl)pentan-2-one (2-Cl) proceeds through a short-lived carbocation intermediate yielding 4-(4´-nitrophenyl)-2-oxopent-4-ene (2-t-ne)as the main elimination product. Addition of acetate ion and other weak bases results in the base-promoted E2 (or E1cb) reaction to give (E)-4-(4´-nitrophenyl)-2-oxopent-3-ene (2-E-ne) and (Z)-4-(4´-nitrophenyl)-2-oxopent-3-ene(2-Z-ne). There is no evidence for a water-promoted E2 (or E1cb) reaction.

    The stereochemistry studies of elimination from (R,S and S,R)-[1-(3´-fluoro)phenyl-2-methyl]cyclopentyl-p-nitrobenzoate (3-PNB) and its (R,R and S,S)isomer 3´-PNB and (R,S and S,R)-[1´-(3´´-fluoro)phenyl-2´-methylcyclopentyl]-2,2,2-trifluoroacetate(3-OOCCF3) exclude the concerted pericyclic elimination mechanism for formation of the alkene 1-(3´-fluoro)phenyl-2-methylcyclopentene(3-m-ne). The effects of added thiocyanate ion and halide ions on the solvolysis reaction are discussed.

    Mass spectrometry analysis showed complete incorporation of the labeled oxygen from solvent water into the product 2-hydroxy-2-phenyl-3-butene (4-OH), confirming that it is the tertiary carbon-oxygen bond that is broken in the acid-catalyzed solvolysis of 2-methoxy-2-phenyl-3-butene (4-OMe). The mechanism for the dominant formation of the less stable 4-OH is discussed.

  • 1032.
    Zettersten, Camilla
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Lomoth, Reiner
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical Chemistry.
    Hammarström, Leif
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical Chemistry.
    Sjöberg, Per
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Nyholm, Leif
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry.
    The influence of the thin-layer flow cell design on the mass spectra when coupling electrochemistry to electrospray ionisation mass spectrometry2006In: Journal of Electroanalytical Chemistry, ISSN 0022-0728, E-ISSN 1873-2569, Vol. 590, no 1, p. 90-99Article in journal (Refereed)
    Abstract [en]

    The influence of the flow cell configuration on the mass spectra obtained when coupling an electrochemical thin-layer flow cell to electrospray mass spectrometry (ESI-MS) has been investigated. It is shown that interferences due to the electrochemical reaction on the counter electrode and/or the absence of 100% conversion efficiency can alter the mass spectra when conventional thin-layer flow cells are used in conjunction with ESI-MS. The effects, which affect the intensities and distribution of the peaks in the mass spectra, can result in the inability to detect products formed at the working electrode. Comparisons of mass spectra, generated after the electrochemical oxidation of a dinuclear Mn complex (where bpmp = 2,6-bis[bis(2-pyridylmethyl) amino]methyl-4-methylphenol) using two different thin-layer flow cells clearly show that the potential dependence and appearance of the mass spectra depend on the flow cell configuration used. The use of a modified thin-layer flow cell, in which the counter electrode had been separated from the working electrode, gave rise to significantly increased intensities for the oxidised MnIII,IV state of the complex. With the conventional unmodified cell, the corresponding complex was only seen for considerably higher oxidation potentials. The different results can be explained by the reduced risk of redox cycling and interferences due to species generated at the counter electrode with the modified cell. As interferences due to the counter electrode reactions likewise may be expected with many coulometric flow cells, the electrochemical cell design clearly needs to be considered when using electrochemistry coupled to ESI-MS to study electrochemical reactions.

  • 1033.
    Zhang, Suode
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Avd för organisk kemi.
    Govender, Thavendran
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Avd för organisk kemi.
    Norström, Thomas
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Avd för organisk kemi.
    Arvidsson, Per
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Avd för organisk kemi.
    An Improved Synthesis of Fmoc-N-methyl-a-amino Acids2005In: J. Org. Chem., no 70, p. 6918-6920Article in journal (Refereed)
  • 1034. Zhukovskii, Y F
    et al.
    Alfredsson, M
    Hermansson, Kersti
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Heifets, E
    Kotomin, E A
    Ab initio simulations of silver film adhesion on alpha-Al2O3 (0001) and MgO (100) surfaces1998In: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, ISSN 0168-583X, E-ISSN 1872-9584, Vol. 141, no 1-4, p. 73-78Article in journal (Refereed)
    Abstract [en]

    The atomic and electronic structure of the Ag/MgO (1 0 0) and Ag/alpha-Al2O3(0 0 0 1) interfaces are calculated by means of the ab initio Hartree-Fock approach combined with a supercell model. The electronic density distribution and the interface binding energy/equilibrium distance for both interfaces are analyzed. For a complete (1:1) surface coverage of the MgO surface the energetically most favorable adsorption position for the Ag atom is above the O atom. For the Ag/alpha-Al2O3 interface the preferable adsorption positions for the Ag atom are over centers of either large equilateral oxygen triangles (in Al-substituted sites of Al-terminated corundum surface) or isosceles oxygen triangles (over O atoms of a first internal oxygen layer) in O-terminated corundum. This interface is less stable than Ag/MgO (1 O 0), due to a large mismatch between lattice constants of Ag (1 1 1) and alpha-Al2O3 (O O O 1) surfaces as well as the instability of Ag atoms on the Al-terminated corundum surface. (C) 1998 Elsevier Science B.V. All rights reserved.

  • 1035. Zuberovic, Aida
    et al.
    Ullsten, Sara
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Hellman, Ulf
    Markides, Karin
    Bergquist, Jonas
    Capillary electrophoresis-off-line-matrix-assisted laser desorption/ionisation mass spectrometry of proteins and peptides using cationic-coated capillariesManuscript (Other academic)
  • 1036.
    Zuberovic, Aida
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Analytisk kemi.
    Ullsten, Sara
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Analytisk kemi.
    Hellman, Ulf
    Markides, Karin E.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Analytisk kemi.
    Bergquist, Jonas
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Analytisk kemi.
    Capillary electrophoresis off-line matrix-assisted laser desorption/ionisation mass spectrometry of intact and digested proteins using cationic-coated capillaries2004In: Rapid Communications in Mass Spectrometry, no 18, p. 2946-2952Article in journal (Refereed)
    Abstract [en]

    Capillary electrophoresis (CE) was coupled off-line with matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOFMS) for the analysis of proteins and peptides. CE fractions were collected directly on a matrix-coated MALDI target, using a sheath-flow interface. Protein adsorption during CE separations was prevented by coating the capillaries with the physically adsorbed, cationic polymer PolyE-323. The CE/MALDI-MS system was used for the analysis of model proteins and peptides at physiological pH as well as analysis of proteins in tear fluid. Moreover, tryptic on-target digestion of the collected protein fractions, with subsequent MALDI-MS and MS/MS peptide analysis, was demonstrated.

  • 1037.
    Ögren, Mattias
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Synthesis of 11C-labelled monosaccharides1997Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The synthesis of some 11C-labelled (tl/2=20.3 min) monosaccharides is presented. Terminal labelled alkenes were synthesized and selectively oxidized using asymmetric dihydroxylation (AD) and palladium(II)-promoted oxidation. The labelled polyols obtained after the AD were submitted to enzymatic oxidations. The use of polymer-bound triphenylphosphine in the synthesis of three 11C-labelled aromatic alkenes was also investigated.

    The 11C-labelled alkenes were synthesized from [11C]methyltriphenyl phosphineiodide. Unreacted triphenylphosphine was quenched prior to the AD. In the synthesis of D-[6-11C]glucose and D-[1-11C]mannitol, the protecting groups were removed by acid hydrolysis and purified on high performance liquid chromatography (HPLC). The decay corrected radiochemical yields were 25 % in the synthesis of D-[6-11C]glucose, and 29 % in the synthesis of D-[1-11C]mannitol.

    In the synthesis of 2-deoxy-D-[1-11C]glucose, the 11C-labelled alkene was oxidized with palladium(II) chloride and water. The resulting labelled aldehyde was deprotected and the product was purified on HPLC. The decay corrected radiochemical yield was 28 %.

    D-[1-11C]Mannitol and D-[ 1-11C]glucitol were synthesized using a Wittig reactionand an AD. Enzymatic oxidation of the two labelled polyols yielded D-[1-11C]fructose and D-[1-11C]glucose, repectively. D-Mannitol dehydrogenase was used for converting D-[1-11C]mannitol to D-[1-11C]fructose and xylitol oxidase for converting D-[1-11C]glucitol to D-[1-11C]glucose. The decay corrected radiochemical yield was 13 % in the synthesis of D-[1-11C]fructose. In the synthesis of D-[1-11C]glucitol the radiochemical yield was low in the AD affording D-[l-11C]glucose in low yield.

    In the polymer-bound synthesis of 11C-labelled aromatic alkenes three aldehydes,benzaldehyde, para-nitrobenzaldehyde and para-methoxybenzaldehyde, were used to synthesize the corresponding alkenes. The decay corrected radiochemical yields were 29-65%.

  • 1038.
    Öhrlund, Åke
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Analytisk kemi.
    The Use of ESCA for Chemical Characterization of Organically Modified Surfaces2001Licentiate thesis, monograph (Other scientific)
  • 1039.
    Örnskov, E.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Linusson, A.
    Folestad, S.
    Determination of dissociation constants of labile drug compounds by capillary electrophoresis2003In: J. of Pharmaceutical and Biomedical Analysis, no 33, p. 379-391Article in journal (Refereed)
  • 1040.
    Örnskov, Eivor
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Analytical Chemistry.
    Physicochemical and Biopharmaceutical Characterisation of Small Drug Molecules by Capillary Electrophoresis2004Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Capillary Electrophoresis (CE) was explored as a means for physicochemical and biopharmaceutical characterisation of small drug molecules. Special attention was paid to the characterisation of acid-base and lipophilic properties of drug compounds by analysing their migration behaviour in different CE systems. The thesis comprises an overview of the field together with separate studies on the different topics.

    The utility of CE for the determination of pKa of labile drug compounds was investigated. A general methodology was developed comprising key steps such as the use of a stabilising sample diluent, electromigration injection, and analyte characterisation by UV-Vis spectroscopy. The methodology was successfully applied for two sets of drug compounds, labile at low and high pH, respectively.

    CE was also evaluated for experimental modelling of passive intestinal membrane permeability by studying analyte migration in liposomal, microemulsion and micellar electrolytes. Good correlation is reported between CE migration and Caco-2 cell absorption estimates and for in vitro inhibition of thrombin. Interestingly, a slightly better correlation was obtained for liposomal electrolytes.

    The utility of liposomes in CE was further extended by developing a novel procedure for immobilising liposomes inside fused silica capillaries. This approach enabled direct on-line coupling of liposome CE to high sensitivity mass spectrometry. The utility of liposome-coated capillaries is demonstrated for estimating drug passive intestinal membrane permeability. Its use in biopharmaceutical drug profiling is discussed.

    Utilising advanced molecular descriptors, commonly applied to in silico prediction of passive intestinal membrane permeability, migration of analytes in micellar CE systems could be well predicted. The novel approach was based on hierarchical multivariate analytics and use of molecular descriptors for both analytes and micellar media surfactants. Demonstrated results propose that the CE format could be useful to validate how representative molecular descriptors are for describing molecular behaviour in complex liquid media, e.g. physiological systems.

    List of papers
    1. Determination of Dissociation Constants of Labile Drug Compounds by Capillary Electrophoresis
    Open this publication in new window or tab >>Determination of Dissociation Constants of Labile Drug Compounds by Capillary Electrophoresis
    2003 In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 33, p. 379-391Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-91392 (URN)
    Available from: 2004-02-13 Created: 2004-02-13Bibliographically approved
    2. Statistical Molecular Design, Parallel Synthesis and Biological Evaluation of a Library of Thrombin Inhibitors
    Open this publication in new window or tab >>Statistical Molecular Design, Parallel Synthesis and Biological Evaluation of a Library of Thrombin Inhibitors
    Show others...
    2001 In: Journal of Medicinal Chemistry, Vol. 44, p. 3424-3439Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-91393 (URN)
    Available from: 2004-02-13 Created: 2004-02-13Bibliographically approved
    3. Experimental Modeling of Passive Drug Absorption by Capillary Electrophoresis using Liposomal, Micellar and Microemulsion Electrolytes
    Open this publication in new window or tab >>Experimental Modeling of Passive Drug Absorption by Capillary Electrophoresis using Liposomal, Micellar and Microemulsion Electrolytes
    In: Journal of Pharmacy & PharmacologyArticle in journal (Refereed) Submitted
    Identifiers
    urn:nbn:se:uu:diva-91394 (URN)
    Available from: 2004-02-13 Created: 2004-02-13Bibliographically approved
    4. Method for Immobilization of Liposomes in Capillary Electrophoresis by Electrostatic Interaction with Derivatized Agarose
    Open this publication in new window or tab >>Method for Immobilization of Liposomes in Capillary Electrophoresis by Electrostatic Interaction with Derivatized Agarose
    Show others...
    2002 In: Electrophoresis, Vol. 23, no 19, p. 3381-3384Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-91395 (URN)
    Available from: 2004-02-13 Created: 2004-02-13Bibliographically approved
    5. Immobilised-Liposome Capillary Electrophoresis - On-line Mass Spectrometry for Biopharmaceutical Drug Profiling
    Open this publication in new window or tab >>Immobilised-Liposome Capillary Electrophoresis - On-line Mass Spectrometry for Biopharmaceutical Drug Profiling
    Show others...
    Manuscript (Other academic)
    Identifiers
    urn:nbn:se:uu:diva-91396 (URN)
    Available from: 2004-02-13 Created: 2004-02-13 Last updated: 2011-03-21
    6. Hierarchical Multivariate Modelling and Prediction of MEKC Migration using Analyte and Micellar Media Molecular Descriptors
    Open this publication in new window or tab >>Hierarchical Multivariate Modelling and Prediction of MEKC Migration using Analyte and Micellar Media Molecular Descriptors
    In: ElectrophoresisArticle in journal (Refereed) Submitted
    Identifiers
    urn:nbn:se:uu:diva-91397 (URN)
    Available from: 2004-02-13 Created: 2004-02-13Bibliographically approved
  • 1041.
    Örnskov, Eivor
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Analytisk kemi.
    Physicochemical Characterisation of Small Drug Molecules by Capillary Electrophoresis2001Licentiate thesis, monograph (Other scientific)
  • 1042.
    Örnskov, Eivor
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Analytical Chemistry.
    Gottfries, Johan
    Erickson, Magnus
    Folestad, Staffan
    Experimental Modeling of Passive Drug Absorption by Capillary Electrophoresis using Liposomal, Micellar and Microemulsion ElectrolytesIn: Journal of Pharmacy & PharmacologyArticle in journal (Refereed)
  • 1043.
    Örnskov, Eivor
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Analytical Chemistry.
    Linusson, Anna
    Folestad, Staffan
    Determination of Dissociation Constants of Labile Drug Compounds by Capillary Electrophoresis2003In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 33, p. 379-391Article in journal (Refereed)
  • 1044.
    Örnskov, Eivor
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Analytical Chemistry.
    Linusson, Anna
    Johansson, Erik
    Folestad, Staffan
    Hierarchical Multivariate Modelling and Prediction of MEKC Migration using Analyte and Micellar Media Molecular DescriptorsIn: ElectrophoresisArticle in journal (Refereed)
  • 1045. Örnskov, Eivor
    et al.
    Ullsten, Sara
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Söderberg, Lennart
    Markides, Karin
    Folestad, Staffan
    Method for immobilization of liposomes in capillary electrophoresis2002In: Electrophoresis, Vol. 23, no 19, p. 3381-3384Article in journal (Refereed)
  • 1046.
    Örnskov, Eivor
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Analytical Chemistry.
    Ullsten, Sara
    Söderberg, Lennart
    Markides, Karin
    Folestad, Staffan
    Method for Immobilization of Liposomes in Capillary Electrophoresis by Electrostatic Interaction with Derivatized Agarose2002In: Electrophoresis, Vol. 23, no 19, p. 3381-3384Article in journal (Refereed)
  • 1047.
    Örnskov, Eivor
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Ullsten, Sara
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Söderberg, Lennart
    Surface Biotechnology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Physical and Analytical Chemistry.
    Markides, Karin
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Folestad, Staffan
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Method for immobilization of liposomes in capillary electrophoresis by electrostatic interaction with derivatized agarose2002In: Electrophoresis, ISSN 3381-3384, Vol. 23, p. 3381-3384Article in journal (Refereed)
    Abstract [en]

    A novel procedure for immobilization of liposomes inside fused-silica capillaries is

    demonstrated. First, the inner wall of the capillaries was coated with a positively

    charged polymer, composed of derivatized agarose. Subsequently, negatively charged

    liposomes were immobilized by electrostatic interaction on the polymer coating. The

    developed liposome coated capillaries were used as a nanoseparation tool for studying

    interactions between small drug compounds and liposomes. Part of this work was

    presented at the 15th International Symposium on Microscale Separations and Analysis,

    HPCE 2002, Stockholm, Sweden, April 2002.

18192021 1001 - 1047 of 1047
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