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  • 151.
    Besev M, Engman L,
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Diastereocontrol by Hydroxyl Auxiliary in the Synthesis of Pyrrolidines via Radical Cyclization2002In: Org. Lett., no 4, p. 3023-Article in journal (Other scientific)
  • 152.
    Besev, M
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Engman, L
    Pyrrolidines from beta-aminoselenides via radical cyclization. Diastereoselectivity control by the N-substituent2000In: ORGANIC LETTERS, ISSN 1523-7060, Vol. 2, no 11, p. 1589-1592Article in journal (Refereed)
    Abstract [en]

    [GRAPHICS] N-Allyl-beta-aminoalkyl phenyl selenides-precursors of 3-aza-5-hexenyl radicals-were prepared by ring opening of N-allylaziridines with benzeneselenol under acidic conditions or by sodium cyanoborohydride reduction of N-allylimines of alpha-phe

  • 153.
    Besev, Magnus
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Pyrrolidines via Radical Cyclization2000Licentiate thesis, monograph (Other scientific)
  • 154.
    Beşev, Magnus
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Radical Cyclization Approaches to Pyrrolidines2002Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Five-membered rings are readily prepared by 5-exo-trig radical cyclization. This thesis is concerned with novel methodology for pyrrolidine synthesis. We have synthesised selenium containing radical precursors from aziridines and α-phenylseleno ketones, and cyclized them to 2,4- and 3,4-disubstituted pyrrolidines. A few examples of 5-exo-dig cyclization were also demonstrated. In another study we investigated the capacity of the nitrogen protecting group to direct diastereoselectivity in the formation of 2,4-disubstituted pyrrolidines. The diphenylphosphinoyl protecting group directed cyclization to occur in a highly cis-selective manner. When cyclizations were performed at 17 oC, cis/trans-ratios as high as 24/1 were obtained. In contrast, cyclization of the unprotected pyrrolidine precursor afforded the trans-diastereomer as the major product (cis/trans = 1/3.3 – 1/20). We also examined the use of a hydroxyl auxiliary for controlling diastereoselectivity in radical cyclization. The required selenium containing radical precursors were synthesised from 2-cyanoaziridines by addition of organometallic reagents, reduction of the resulting aziridine ketone, and benzeneselenol ring-opening of the aziridine. Cyclization at 17 oC produced 2,4-disubstituted pyrrolidines substantially enriched in the trans-isomer (cis/trans = 1/9 – 1/12). Novel radical cyclization approaches to thiazolines and pyrrolines were also tried.

    The thesis also describes attempts to improve the Hassner aziridine synthesis by employing stannous chloride as a functional group tolerant reducing agent.

  • 155.
    Bhaskaran, Nimesh
    et al.
    Karolinska University Hospital.
    Iwahana, Hiroyuki
    Karolinska University Hospital.
    Bergquist, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Hellman, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Souchelnytskyi, Serhiy
    Karolinska University Hospital.
    Novel post-translational modifications of Smad2 identified by mass spectrometry2008In: Central European Journal of Biology, ISSN 1895-104X, E-ISSN 1644-3632, Vol. 3, no 4, p. 359-370Article in journal (Refereed)
    Abstract [en]

    Smad2 is a crucial component of transforming growth factor-b (TGFb) signaling, and is involved in the regulation of cell proliferation,death and differentiation. Phosphorylation, ubiquitylation and acetylation of Smad2 have been found to regulate its activity. We usedmass spectrometry to search for novel post-translational modifications (PTMs) of Smad2. Peptide mass fingerprinting (PMF) indicatedthat Smad2 can be acetylated, methylated, citrullinated, phosphorylated and palmitoylated. Sequencing of selected peptides validatedmethylation at Gly122 and hydroxylation at Trp18 of Smad2. We also observed a novel, so far unidentified modification at Tyr128 andTyr151. Our observations open for further exploration of biological importance of the detected PTMs.

  • 156. Bischof, Gerhard
    et al.
    Silbernagl, Alexander
    Hermansson, Kersti
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Probst, Michael
    Quantum chemical study of the molecular dynamics of hydrated Li+ and Be2+ cations1997In: International Journal of Quantum Chemistry, ISSN 0020-7608, E-ISSN 1097-461X, Vol. 65, no 5, p. 803-816Article in journal (Refereed)
    Abstract [en]

    Molecular dynamics simulations of clusters of Li+ and Be2(+) cations with up to 12 water molecules were performed calculating the particle trajectories using Hartree-Fock-derived forces. It was found that independent of the starting configuration tetrahedral clusters are obtained in less than 1 ps. Only for Li+ clusters, transition states with five and three water molecules are found. We discuss the structures of the clusters and the vibrational dynamics of the water molecules and compare them with other ab initio simulations, with simulations using analytical potential functions, and with static calculations. Water-dissociation (hydrogen transfer) reactions which take place at elevated temperatures were investigated. (C) 1997 John Wiley & Sons, Inc.

  • 157.
    Bjorefors, F
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Gadomska, J
    Donten, M
    Nyholm, L
    Stojek, Z
    Influence of mixed diffusional, migrational, and convective mass transport on the response of a wall-tube microelectrode in a flow injection system1999In: ANALYTICAL CHEMISTRY, ISSN 0003-2700, Vol. 71, no 21, p. 4926-4931Article in journal (Refereed)
    Abstract [en]

    The current response of a 10-mu m walt-tube microelectrode in a now injection system under the conditions of low ionic strength has been examined experimentally for several redox systems such as ferrocene in methanol, undiluted methanol, and water in ace

  • 158.
    Bjorefors, F
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Nyholm, L
    Stripping voltammetry at preplated mercury coated microelectrodes in flowing solutions1996In: ANALYTICA CHIMICA ACTA, ISSN 0003-2670, Vol. 325, no 1-2, p. 11-24Article in journal (Refereed)
    Abstract [en]

    A flow system is described in which stable preplated mercury coatings on microelectrodes can be obtained due to minimised handling of the electrode and the fact that potentiostatic control can be maintained also between the experiments. Compared to the d

  • 159.
    Bjorefors, F
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Nyholm, L
    Donten, M
    Stojek, Z
    Amperometric determination of the water content in acetone, butter and margarine using a wall-tube platinum microelectrode in a flow injection system1999In: ANALYST, ISSN 0003-2654, Vol. 124, no 2, p. 143-146Article in journal (Refereed)
    Abstract [en]

    Amperometric determinations of the water content in acetone, butter and margarine were performed using a wall-tube platinum microelectrode in combination with a flow injection system. For the butter and margarine samples, acetone containing small amounts

  • 160.
    Björefors, Fredrik
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Fundamental investigations and applications of microelectrode based detections in flowing solutions1999Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The influence of diffusional, migrational and convective mass transport at microelectrodes employed for voltammetric and amperometric detection in flowing solutions has been investigated. Special attention was paid to the influence of convection on the IR drop in organic solvents and on the transport of reaction products between individual electrode bands of microarray electrodes. A flow injection system was also designed to study the stability of mercury films coated on microelectrodes for the purpose of stripping analysis.

    Increased influence of convection, obtained by altering the flow rate or by changing the position of the microelectrode in a wall-tube flow cell, at low support ratios in organic solvents was found to result in decreased currents as a consequence of the inability to maintain a sufficient amount of ions at the vicinity of the microelectrode surface. Successful determinations of the water content in butter and margarine could be performed in an acetone based flow injection system, provided that the detection potential was chosen to accommodate the different support ratios in the injected solutions.

    The degree of redox cycling at interdigitated microarray electrodes was found to increase if the flow rate was reduced from 20 to 2 µl/min. Even at these low flow rates, the degree of redox cycling in stationary solutions was, however, always larger compared to the values obtained under the influence of convection. A microarray electrode was also employed to improve the selectivity in the detection of poorly separated species in capillary electrophoresis.

    By employing a flow injection system, it was found that the stability of mercury films plated on platinum and carbon fibre microelectrodes could be improved as potential control could be maintained during solution exchange and between individual experiments. Stripping voltammetric determinations of nickel at nM concentrations and of copper in a low ionic strength solution was demonstrated in the flow injection system.

  • 161. Björkman, M.
    et al.
    Doi, H.
    Resul, B.
    Suzuki, M.
    Noyori, R.
    Watanabe, Y.
    Långström, B.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Synthesis of a 11C-labelled prostaglandin F2-alfa analogue using an improved method for Stille reactions with (11C)methyl iodide2000In: J.Labelled Compd. Radiopharm., ISSN 0362-4803, Vol. 43, no 14, p. 1327-1334Article in journal (Refereed)
  • 162. Björkman, M.
    et al.
    Långström, B
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Functionalization of 11C-labeled olefins via a Heck couplin reaction.2000In: Journal of the Chemical Society-Perkin Transactions, ISSN 1470-4358, Vol. 1, no 18, p. 3031-34Article in journal (Other scientific)
  • 163.
    Björkman, Margareta
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Palladium-promoted synthesis of compounds labelled with ¹¹C: Synthesis of ¹¹C-labelled prostacyclin and prostaglandin analogues2000Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Palladium-promoted reactions have been employed for the synthesis of compounds labelled with 11C (t½ = 20.3 min). The precursor [11C]methyl iodide was used in palladium-promoted cross-coupling reactions with organostannanes. With this method, large molecules with several functional groups, that is prostacyclin analogues, have been synthesised in up to 54 % decay-corrected radiochemical yield, calculated from [11C]methyl iodide. However, since this method did not afford reproducible yields, a second method where copper(I) was used as a co-catalyst with palladium, was developed. In the second method, a lower reaction temperature could be used and more reproducible yields were obtained. Employing this method, a prostaglandin analogue was synthesised in 34 % decay-corrected radiochemical yield calculated from [11C]methyl iodide. The total synthesis time was 30 min and the radiochemical purity was higher than 95 %. The specific radioactivity of the compounds obtained with these two methods was approximately 100 GBq/μmol.

    11C-Labelled aliphatic and aromatic alkenes were synthesised from [11C]methyl iodide in a Wittig olefination reaction using a published method. The 11C-labelled alkenes were reacted with five aromatic halidein Heck coupling reactions, producing five [11C]stilbene analogues in 34-40 % decay-corrected radiochemical yield. The radiochemical purity was higher than 95 % and the total synthesis timwas 40 min.

    11C-Labelled alkenes were also synthesised from 11C-labelled aldehydes. The 11C-labelled aldehydes were obtained from [11C]carbon monoxide in a palladium-mediated formylation of aryl iodides in 51-87 % radiochemical yield, determined by analytical LC and corrected for trappinefficiency. A range of palladium catalysts and hydride reagents were investigated. The labelled aldehydes were used in a subsequent Wittig olefination reaction where various Wittig salts were employed tsynthesise a variety of alkenes. The radiochemical yields were 30-76 %, determined by analytical LC.

  • 164.
    Blomquist, G.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Engler, H.
    Wall, A.
    Sandell, J.
    Koivisto, P.
    Långström, B.
    Reference tissue methods in analyzing brain uptake of PIB with PET2003In: EANM, Amsterdam, 2003Conference paper (Other scientific)
  • 165.
    Bohl E, Carlsson J, Edwards K, Sjöberg S, Gedda L
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    SLT-particles for twostep targeting in boron neutron capture therapy2001In: Frontiers in neutron capture therapy, p. 1069-1075Article in journal (Other scientific)
  • 166.
    Bohl Kullberg E, Carlsson J, Edwards K, Capala J, Sjöberg S, Gedda L.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Introductory Experiments On Ligand Liposomes as Delivery Agents for Boron Neutron Capture Therapy2003In: International Journal of Oncology, no 23, p. 461-467Article in journal (Other scientific)
  • 167.
    Bonasera T., Grue-Sorensen G., Ortu G., Binderup E., Bergström M., Björkling F., Långström B.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    The Synthesis of [26,27-11C]dihydroxyvitam in D3, a tracer for positron emission tomography (PET)2001In: Bioorganic & Medical Chemistry, no 9(12), p. 3123-312Article in journal (Refereed)
  • 168.
    Borbath, I
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Gregoire, V
    Bergström, M
    Laryea, D
    Långström, B
    P.S,
    Use of 5-[(76)Br]bromo-2'-fluoro-2'.deoxyuridine as a ligand for tumour proliferation: validation in an animal tumour model2002In: Eur. J. Nucl. Med. Mol. Imaging, Vol. 1, no 29, p. 19-27Article in journal (Other scientific)
  • 169. Brandt, P
    et al.
    Andersson, P G
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Exploring the chemistry of 3-substituted 2-azanorbornyls in asymmetric catalysis.2000In: Synlett, ISSN 0936-5214, no 8, p. 1092-1106Article in journal (Other scientific)
  • 170.
    Brandt, P
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Andersson, P.G.
    A DFT Exploration of the Enantiolselective Rearrangement of Cyclohexene Oxide to Cyclohexenol2003In: Tetrahedron, no 59, p. 9695-Article in journal (Refereed)
  • 171.
    Brandt P, Hedberg C, Andersson P.G
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    New Mechanistic Insights into the Ir-(phosphano-oxazoline) Catalysed Hydrogenation of Unfunctinalized Olefines: A DFT and Kinetic Study2003In: Chem. Eur. J., no 9, p. 339-Article in journal (Other scientific)
  • 172. Brandt, Peter
    et al.
    Andersson, Pher
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Exploring the Chemistry of 3-Substituted 2-Azanorbornyls in Asymmetric Catalysis2000In: Synlett, no 8, p. 1092-1106Article in journal (Refereed)
    Abstract
  • 173. Brandt, Peter
    et al.
    Hedberg, Christian
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Andersson, Pher
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    New Mechanistic Insights into the Iridium-Phosphanooxazoline-Catalyzed Hydrogenation of Unfunctionalized Olefins: A DFT and Kinetic Study2003In: Chem. Eur. J., no 9, p. 339-347Article in journal (Refereed)
    Abstract
  • 174. Brandt, Peter
    et al.
    Hedberg, Christian
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Andersson, Pher G.
    New Mechanistic Insights into the Iridium-Phosphanooxazoline Catalyzed Hydrogenation of Unfunctionalized Olefins: A DFT and Kinetic Study2003In: Chemistry-A European Journal, ISSN 0022-3263, Vol. 9, no 1, p. 339-347Article in journal (Refereed)
    Abstract
  • 175. Brandt, Peter
    et al.
    Hedberg, Christian
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Lawonn, Klaus
    Pinho, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Andersson, Pher
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    A Theoretical and Experimental Study of the Asymmetric Addition of Dialkylzinc to N-(Diphenylphosphinoyl)benzalimine1999In: Chem. Eur. J., no 5, p. 1692-1699Article in journal (Refereed)
    Abstract
  • 176. Brandt, Peter
    et al.
    Hedberg, Christian
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Lawonn, Klaus
    Pinho, Pedro
    Andersson, Pher G.
    A Theoretical and Experimental Study of the Asymmetric Addition of Dialkylzinc to N-(diphenylphosphinoyl)benzalimine1999In: Chemistry-A European Journal, ISSN 0947-6539, Vol. 5, no 6, p. 1692-1699Article in journal (Refereed)
    Abstract
  • 177. Brandt, Peter
    et al.
    Roth, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Andersson, Pher
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Origin of Enantioselectivity in the Ru(arene)(amino alcohol)-Catalyzed Transfer Hydrogenation of Ketones2004In: J. Org. Chem., no 69, p. 4885-4890Article in journal (Refereed)
    Abstract
  • 178.
    Brandt, Peter
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Södergren, Mikael
    Andersson, Pher
    Department of Chemistry. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Norrby, Per-Ola
    Mechanistic Studies of Copper-Catalyzed Alkene Aziridination2000In: J. Am. Chem. Soc., ISSN 0002-7863, no 122, p. 8013-8020Article in journal (Refereed)
  • 179.
    Bratt K, Sunnerheim K, Bryngelsson S, Fagerlund A, Engman L, Andersson R.E, Dimberg L.H
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Avenanthramides in Oats (Avena sativa L.) and Structure-Antioxidant Activity Relationships2003In: J. Agric. Food Chem, no 51, p. 594-Article in journal (Other scientific)
  • 180.
    Bratt, K
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Sunnerheim, K
    Bryngelsson, S
    Fagerlund, A
    Engman, L
    Häll, Dimberg L.
    Avenanthramides in Oats: Structure - Antioxidant Activity Relationsip2003In: J. Agric Food Chem., no 51, p. 594-600Article in journal (Other scientific)
  • 181.
    Bratt K, Sunnerheim K., Nordenhem H., Nordlander G., Långström B.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Pine Weevil (Hylobius abietis) Antifeedants from Lodgepole Pine (Pinus contorta)2001Article in journal (Other scientific)
  • 182.
    Bratt, Katharina
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Secondary plant metabolites as defence against herbivores and oxidative stress: Synthesis, isolation and biological evaluation2000Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In this thesis the isolation, synthesis and biological evaluation of natural defense compounds against herbivores or oxidative stress is discussed.

    The first part concerns the metabolites of platyphylloside ((5S)-5-hydroxy-1,7-bis-(4-hydroxyphenyl)-3-heptanone-5-O-β-D-glucopyranoside), a phenolic glucoside found in birch (Betula pendula) that possess digestibility inhibiting activity in herbivores. The structure-activity relationship of platyphylloside analogues were investigated regarding to stereochemistry and substitution pattern on the aromatic rings. The metabolites formed in vitro in rumen fluid were synthesized and the active metabolite determined as (R)-centrolobol (1,7-bis-(4-hydroxyphenyl)-3-heptanol). Treatment of mice and rats with rac-centrolobol did not effect either food intake or body weight. Effect of platyphylloside in moose was also investigated, and the results indicate that there was an in vivo digestibility reducing activity.

    The second part concerns naturally occurring antioxidants. Avenanthramides is a class of phenolic antioxidants found in oat (Avena sativa). Avenanthramides derived from either anthranilic acid or 5-hydroxyanthranilic acid were evaluated for their antioxidative capacity and quantified in oat extracts. Avenanthramides derived from 5-hydroxyanthranilic acid possessed higher activity than those from anthranilic acid. The order of reactivity depending on substitution pattern on the phenolic moiety was found to be 4-hydroxy < 4-hydroxy-3-methoxy < 3,5-dimethoxy-4-hydroxy and 3,4-dihydroxy. A synthesis towards antioxidative compounds such as 4-deoxycarbazomycin was developed.

    The third part concerns the isolation of compounds from Lodgepole pine (Pinus contorta) with antifeedant activity against pine weevil (Hylobius abietis). Two compounds possessing high activity were isolated and identified.

  • 183.
    Braunschweig, F.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Sörensen, J.
    von Bibra, H.
    Olsson, A.
    Ryden, L.
    Långström, B.
    Linde, C.
    Effects of long-term biventricular pacing on myocardial blood flow and oxygen consumption. A study using 11C-acetate-PET2003In: Am. J. Cardiol., Vol. 92, no 425, p. 95-99Article in journal (Refereed)
  • 184. Bregadze, V I.
    et al.
    Sivaev, I.
    Bruskin, A.
    Sjöberg, S.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Nesterov, V.
    Antipin, M.
    Synthesis of Schiff bases and monoalkylamino derivatives of closododecaborae(2-) anion2000In: Contemporary Boron ChemistryArticle in journal (Other scientific)
  • 185.
    Bregadze V, Sivaev I, Sjöberg S
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Synthesis of Functional Derivatives of Cobalt Bis(1,2-dicarolide) Anion for BNCT.2002In: Research and Development in Neutron Capture Therapy, p. 13-17Article in journal (Other scientific)
  • 186.
    Brink, M
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Mollerstedt, H
    Ottosson, CH
    Characteristics of the electronic structures of diabatically and adiabatically Z/E-isomerizing olefins in the T-1 state2001In: JOURNAL OF PHYSICAL CHEMISTRY A, ISSN 1089-5639, Vol. 105, no 16, p. 4071-4083Article in journal (Refereed)
    Abstract [en]

    Nonlocal gradient-corrected and hybrid density functional theory (DFT) have been used to calculate T1 potential energy surfaces (PES), spin densities, and geometries of ethylene and aromatic olefins of various sizes: ethylene (1), styrene (2), stilbene (3

  • 187.
    Broadbent, JK
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Martincigh, BS
    Raynor, MW
    Salter, LF
    Moulder, R
    Sjoberg, P
    Markides, KE
    Capillary supercritical fluid chromatography combined with atmospheric pressure chemical ionisation mass spectrometry for the investigation of photoproduct formation in the sunscreen absorber 2-ethylhexyl-p-methoxycinnamate1996In: JOURNAL OF CHROMATOGRAPHY A, ISSN 0021-9673, Vol. 732, no 1, p. 101-110Article in journal (Refereed)
    Abstract [en]

    The photoproducts formed on ultraviolet irradiation of the sunscreen absorber trans-2-ethylhexyl-p-methoxycinnamate, were separated and characterised using a new combined technique, capillary supercritical fluid chromatography-atmospheric pressure chemic

  • 188.
    Broddefalk, A
    et al.
    INORGANIC CHEMISTRY. Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science.
    James, P
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics.
    Liu, HP
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Kalska, B
    Andersson, Y
    Granberg, P
    Nordblad, P
    Haggstrom, L
    Eriksson, I
    Structural and magnetic properties of (Fe1-xMnx)3P (x < 0.25)2000In: PHYSICAL REVIEW B, ISSN 1098-0121, Vol. 61, no 1, p. 413-421Article in journal (Refereed)
    Abstract [en]

    Structural and magnetic properties of (Fe1-xMnx)(3)P compounds have been investigated by means of x-ray and neutron diffraction experiments, magnetization measurements, Mossbauer experiments, and first principles calculations. The Curie temperature of the

  • 189.
    Bruskin, Alexander
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
    Sivaev, Igor
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Persson, Mikael
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
    Lundqvist, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
    Carlsson, Jörgen
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
    Sjöberg, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
    Radiobromination of monoclonal antibody using potassium [76Br] (4 isothiocyanatobenzyl-ammonio)-bromo-decahydro-closo-dodecaborate (Bromo-DABI)2004In: Nuclear Medicine and Biology, ISSN 0969-8051, E-ISSN 1872-9614, Vol. 31, no 2, p. 205-11Article in journal (Refereed)
    Abstract [en]

    The use of charged linkers in attaching radiohalogens to tumor-seeking biomolecules may improve intracellular retention of the radioactive label after internalization and degradation of targeting proteins. Derivatives of polyhedral boron clusters, such as closo-dodecaborate (2-) anion, might be possible charged linkers. In this study, a bifunctional derivative of closo-dodecaborate, (4-isothiocyanatobenzyl-ammonio)-undecahydro-closo-dodecaborate (DABI) was labeled with positron-emitting nuclide (76)Br (T 1/2 = 16.2 h) and coupled to anti-HER2/neu humanized antibody Trastuzumab. The overall labeling yield at optimized conditions was 80.7 +/- 0.6%. The label was proven to be stable in vitro in physiological and a set of denaturing conditions. The labeled antibody retained its capacity to bind to HER-2/neu antigen expressing cells. The results of the study demonstrated feasibility for using derivatives of closo-dodecaborate in indirect labeling of antibodies for radioimmunoPET.

  • 190.
    Bucur, R.V.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Organisk kemi.
    Berger, R
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Oorganisk kemi.
    Electrochemical measurements in aqueous solution of the solid-state diffusion of Cu+ in various binary and ternary copper sulphides1996In: Baltic conference on interfacial electrochemistry (Extended abstracts): Tartu, Juni 14-18, 1996, 1996, p. 49-50Conference paper (Other (popular scientific, debate etc.))
    Abstract [en]

    While solid-state diffusion is in general a slow process, exceptions are found in certain kinds of inorganic materials, predominantly concerning small cations moving in an environment of large and chemically soft anions. [...] We have used a potentiometric method, recording the change in potential after a perturbing current pulse and have studied three sulphides under the [radioactive waste] repositary conditions, namely chalcocite, chalcopyrite and bornite

  • 191.
    BUCUR, RV
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Oorganisk kemi.
    BERGER, R
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Oorganisk kemi.
    ELECTROCHEMICAL POTENTIOMETRIC DETERMINATION OF THE DIFFUSION-COEFFICIENT OF COPPER IN LOW DIGENITE, A COPPER SULFIDE1995In: Solid State IonicsArticle in journal (Refereed)
    Abstract [en]

    The diffusion of copper in ''low digenite'', Cu1.8S, has been measured by an electrochemical potentiometric method within the temperature range 15-50 degrees C. At 25 degrees C the chemical diffusion coefficient ($) over tilde D is 1.8(1) x 10(-8) cm(2)/

  • 192.
    Buttner, Frank
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. avd för organisk kemi.
    Norgren, Anna
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. avd för organisk kemi.
    Zhang, Suode
    Prabpai, Samran
    Kongsaeree, Palangpon
    Arvidsson, Per
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. avd för organisk kemi.
    Cyclic B-Tetra- and Pentapeptides: Synthesis through On-Resin Cyclization and Confomrational Studies by X-Ray, NMR and CD Spectroscopy and Theoretical Calculations2005In: Chem. Eur. J., Vol. 11, p. 6145-6158Article in journal (Refereed)
    Abstract [en]

    The solution-phase synthesis of the simplest cyclic B-tetrapeptide, cyclo(B-Ala)4 (4), as well as the solidphase syntheses through side chain anchoring and on-resin cyclization of the cyclic B3-tetrapeptide cyclo-(B3hPhe-B3hLeu-B3hLys-B3hGln-) (14) and the first cyclic B3-pentapeptide cyclo- (B3hVal-B3hPhe-B3Leu- B3hLys-B3hLys-) (19) are reported. Extensive computational as well as spectroscopic studies, including X-ray and NMR spectroscopy, were undertaken to determine the preferred conformations of these unnatural oligomers in solution and in the solid state. cyclo(B-Ala)4 (4) with no chiral side chains is shown to exist as a mixture of rapidly interchanging conformers in solution, whereas inclusion of chiral side chains in the cyclo-B3-tetrapetpride causes stabilizaton of one dominating conformer. The cyclic B3-pentapeptide on the other hand shows larger conformational freedom. The X-ray structure of achiral cyclo(B-Ala)4 (4) displays a Ci-symmetrical 16-membered ring with adjacent C=O and N-H atoms pointing pair wise up and down with respect to the ring plane. CD spectorscopic examinations of all cyclic B-peptides were undertaken and revealed results valuable as starting point for further structural investigations of these entities.

  • 193.
    Bylund, D.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Danielsson, R.
    Malmquist, G.
    Markides, K.E.
    Chromatographic alignment by warping and dynamic programming as a pre-processing tool for PARAFAC modelling of liquid chromatography - mass spectrometry data2002In: J. of Chromatography A, no 961, p. 237-244Article in journal (Refereed)
  • 194.
    Bylund, D
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Danielsson, R
    Markides, KE
    Peak purity assessment in liquid chromatography-mass spectrometry2001In: JOURNAL OF CHROMATOGRAPHY A, ISSN 0021-9673, Vol. 915, no 1-2, p. 43-52Article in journal (Refereed)
    Abstract [en]

    Fixed-size moving window evolving factor analysis and base peak chromatograms have been used for peak purity detection in data generated with LC-MS. The two methods were evaluated with both real and simulated data and were found to be fast and complementa

  • 195.
    Bylund, D.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Samskog, J.
    Jacobsson, S.P.
    Markides, K.E.
    Classification of Lactate Dehydrogenase of Different Origin by Liquid Chromatography-Mass Spectrometry and Multivariate Analysis2003In: J. Am. Soc. Mass Spectrom., no 14, p. 236-240Article in journal (Refereed)
  • 196.
    Bylund, Dan
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Chemometric Tools for Enhanced Performance in Liquid Chromatography-Mass Spectrometry2001Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Liquid chromatography-mass spectrometry (LC-MS) has become an important analytical on-line technique, capable of producing large amounts of data with high selectivity and sensitivity. Optimal use of the sophisticated instrumentation can be attained if the analytical chemists are guided to perform the proper experiments and to extract the useful information from the acquired data. In this thesis, strategies and methods concerning these two issues are presented.

    LC-MS method development will benefit from fundamental understanding of the processes involved. An experimental procedure was designed to determine the coefficients in a model for the electrospray process. By relating these coefficients to the experimental conditions, the influence on signal level and sensitivity for presence of matrix compounds was studied.

    For the optimization of LC-MS methods, strategies based on empirical modelling were worked out. Comparisons were made between artificial neural network (ANN) modelling and linear modelling tools, and a genetic algorithm was implemented to explore the ANN models.

    Visual interpretation and multivariate analysis of LC-MS data is hampered by background signals and noise, and a digital filter for background suppression and signal-to-noise improvement was developed. It is also important to indicate the presence of overlapping peaks, and a strategy for the assessment of peak purity was therefore worked out. These methods and several established methods were implemented in an add-on program (LC-MS Toolbox 1.0) for information extraction of LC-MS data.

    Ultimately, the data produced with LC-MS can be separated into the mass spectra, the elution profiles and the concentrations of the analytes, e.g. with PARAFAC modelling. The trilinear data structure assumed may, however, be distorted by variations in the LC conditions causing retention time shifts. An improved algorithm for time warping that can compensate for some of these deviations was worked out, and its performance as a pre-processing tool for PARAFAC was examined.

  • 197. Bylund, Dan
    et al.
    Samskog, Jenny
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Analytical Chemistry.
    Jacobsson, Sven P
    Markides, Karin E
    Classification of lactate dehydrogenase of different origin by liquid chromatography-mass spectrometry and multivariate analysis2003In: J Am Soc Mass Spectrom, Vol. 14, no 2, p. 236-240Article in journal (Refereed)
  • 198.
    Bäckström, Daniel
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Allard, Erik
    Danielsson, Rolf
    Sjöberg, Per
    Bergquist, Jonas
    Comparing CE-MS fingerprints of urine samples, obtained after intake of coffee, tea or waterManuscript (Other academic)
  • 199. Bäckvall, Jan-E.
    et al.
    Andersson, Pher
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Intramolecular Palladium-Catalyzed 1,4-Addition to Conjugated Dienes. Stereoselective Synthesis of Fused Tetrahydrofurans and Tetrahydropyrans1992In: J. Am. Chem. Soc, Vol. 114, no 16, p. 6374-6381Article in journal (Refereed)
  • 200. Bäckvall, Jan-E.
    et al.
    Andersson, Pher
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Palaldium-Catalyzed Stereocontrolled Intramolecular 1,4-Additions to Cyclic 1,3-Dienes Involving Amides as Nucleophiles1990In: J. Am. Chem. Soc, Vol. 112, no 9, p. 3683-3685Article in journal (Refereed)
1234567 151 - 200 of 1047
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