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  • 251.
    Engman, Lars
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Organic Chemistry.
    McNaughton, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Organic Chemistry.
    Gajewska, Malgorzata
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Organic Chemistry.
    Kumar, Sangit
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Organic Chemistry.
    Birmingham, Anne
    Powis, Garth
    Thioredoxin reductase and cancer cell growth inhibition by organogold(III) compounds2006In: Anti-Cancer Drugs, ISSN 0959-4973, E-ISSN 1473-5741, Vol. 17, no 5, p. 539-544Article in journal (Refereed)
    Abstract [en]

    Thioredoxin (Trx) expression is increased in several human primary cancers associated with aggressive tumor growth and decreased patient survival, and the Trx/Trx reductase (TrxR) system therefore provides an attractive target for cancer drug development. Various gold(III) compounds with none, one, two or three carbon-gold bonds were evaluated for their capacity to inhibit TrxR and the growth of MCF-7 cancer cells in vitro. Compounds with up to two carbon-gold bonds were often potent inhibitors of TrxR with IC50 values as low as 2 nmol/l. In the presence of Trx and insulin the inhibiting capacity was much lower. However, the inhibitory concentrations of the compounds did not correlate with the ability to kill cells. Out of the organometallics tested, only compound 8 with two carbon-gold bonds was able to inhibit colony formation by MCF-7 breast cancer cells at low micromolar concentrations (IC50=1,6umol/l). Unfortunately, the compound did not show any anti-tumor activity against MCF-7 breast cancer and HT-29 colon cancer zenografts in scid mice.

  • 252.
    Engman, Lars
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Organisk kemi.
    Wojtón, A
    Oleksyn, B. J
    Sliwinski, J
    The crystal structure of 2-[N,N-dimethylamino)methyl] benzenetellurenyl chloride2004In: Phosphorus, Sulfur, and Silicon, ISSN 1042-6507, Vol. 179, p. 285-292Article in journal (Refereed)
    Abstract [en]

    The crystal structure of 2-[(N,N-dimethylamino)methyl]benzenetellurenyl chloride (2), a compound previously formulated as bis [[2-(N,N-dimethylamino)methyl]phenyl] ditelluride bis hydrochloride (1a), was determinded. In the molecule 2, tellurium is bonded to the carbon of the phenyl group [2.120(3)Å], the nitrogen o fthe ortho dimethylamino substituent [2.362(3)Å], and the chlorine atom [2.536[1]Å]. There also is an intermolecular interaction of the tellurium atom with the phenyl ring of a neighbouring molecule [3.655(1)Å], resulting in the formation of zigzag chains along the b axis. The noncentorsymmetric space group of the crystal can be explained by the chiral surrounding of tellurium.

  • 253.
    Engqvist, H
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Technology, Department of Materials Science. MATERIALS SCIENCE/TRIBOMATERIALS.
    Hogberg, H
    Chemistry, Department of Chemistry.
    Botton, GA
    Ederyd, S
    Axen, N
    Tribofilm formation on cemented carbides in dry sliding conformal contact2000In: WEAR, ISSN 0043-1648, Vol. 239, no 2, p. 219-228Article in journal (Refereed)
    Abstract [en]

    The friction properties and the tribofilm formation of a binderless cemented carbide and two conventional cemented carbides have been evaluated in an unlubricated sliding contact in either air or nitrogen surroundings. A continuously varied normal load an

  • 254.
    Enierga, G
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Espiritu, M
    Perlmutter, P
    Pham, N
    Rose, M
    Sjoberg, S
    Thienthong, N
    Wong, K
    Intramolecular amidomercurations under allylic control: a stereoselective synthesis of (+)-pseudohygroline and (+)-3-hydroxypyrrolizidine2001In: TETRAHEDRON-ASYMMETRY, ISSN 0957-4166, Vol. 12, no 4, p. 597-604Article in journal (Refereed)
    Abstract [en]

    The diastereoselectivity of intramolecular amidomercurations can be reversed by altering the remote allylic substituent of omega -alkenylcarbamates. This methodology has been applied to the synthesis of (+)-pseudohygroline and (+)-3-hydroxypyrrolizidine.

  • 255.
    Erdélyi, M
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Gogoll, A
    Rapid Microwave-Assisted Solid Phase Peptide Synthesis.2002In: Synthesis, p. 1592-Article in journal (Other scientific)
  • 256.
    Erdélyi, M
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Langer, V
    Karlén, A
    Gogoll, Adolf
    Insight into B-Hairpin Stability: A Structural and Thermodynamic Study of Diastereomeric B-Hairpin Mimetics2002In: New J. Chem., no 26, p. 834-Article in journal (Other academic)
  • 257.
    Erdélyi, Máté
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Development of new mimetics for b-hairpins. Synthesis, structure and conformation2002Licentiate thesis, monograph (Other scientific)
  • 258.
    Erdélyi, Máté
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Towards the Development of Photoswitchable β-Hairpin Mimetics2004Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Peptide secondary structure mimetics are important tools in medicinal chemistry, as they provide analogues of endogeneous peptides with new physicochemical and pharmacological properties. The β-hairpin motif has been shown to be involved in numerous physiological processes, among others in regulation of eucariotic gene transcription. This thesis addresses the design, synthesis and conformational analysis of photoswitchable β-hairpin mimetics.

    The developmental work included the establishment of an improved procedure for cross coupling of aryl halides with terminal alkynes. Microwave mediated Sonogashira couplings in closed vessels were optimized under homogeneous and solid-phase conditions furnishing excellent yields for a large variety of substrates within 5 – 25 minutes. In addition, microwave heating was shown not to have any non-conventional effect on the reaction rate.

    Furthermore, the most important factors affecting β-hairpin stability were evaluated. Studies of tetrapeptide and decapeptide analogues revealed the essential role of the β-turn in initiation of hairpin folding. Moreover, hydrogen bonding was shown to be the main interchain stabilizing force, whereas hydrophobic interactions were found to be relatively weak. Nevertheless, hydrophobic packing appears to provide an important contribution to the thermodynamic stability of β-hairpins.

    Photoswitchable peptidomimetics were prepared by incorporation of various stilbene moieties into tetra- and decapeptides. Synthesis, photochemical isomerisation and spectroscopic conformational analysis of the compounds were performed.

    List of papers
    1. Rapid Homogeneous-Phase Sonogashira Coupling Reactions Using Controlled Microwave Heating
    Open this publication in new window or tab >>Rapid Homogeneous-Phase Sonogashira Coupling Reactions Using Controlled Microwave Heating
    2001 In: Journal of Organic Chemistry, Vol. 66, no 12, p. 4165-4169Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-91463 (URN)
    Available from: 2004-03-11 Created: 2004-03-11Bibliographically approved
    2. Rapid Microwave Promoted Sonogashira Coupling Reactions on Solid Phase
    Open this publication in new window or tab >>Rapid Microwave Promoted Sonogashira Coupling Reactions on Solid Phase
    2003 (English)In: Journal of Organic Chemistry, Vol. 68, no 16, p. 6431-6434Article in journal (Refereed) Published
    Abstract [en]

    A microwave-enhanced, rapid, and efficient solidphase version of the Sonogashira reaction is presented. It has been applied to the coupling of aryl iodides and bromides with various acetylene derivatives giving excellent yields in 15 to 25 min. The scopes of homogeneous, solventless, and solid-phase conditions for Sonogashira coupling of aryl halides are compared.

    National Category
    Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-91464 (URN)10.1021/jo034284s (DOI)
    Available from: 2004-03-11 Created: 2004-03-11 Last updated: 2011-01-05
    3. Insight into β-Hairpin Stability: A Structural and Thermodynamic Study of Diastereomeric β-Hairpin Mimetics
    Open this publication in new window or tab >>Insight into β-Hairpin Stability: A Structural and Thermodynamic Study of Diastereomeric β-Hairpin Mimetics
    2002 In: New Journal of Chemistry, Vol. 26, p. 834-843Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-91465 (URN)
    Available from: 2004-03-11 Created: 2004-03-11Bibliographically approved
    4. Synthesis and Conformational Analysis of Novel Stibene-type Peptidomimetics
    Open this publication in new window or tab >>Synthesis and Conformational Analysis of Novel Stibene-type Peptidomimetics
    Show others...
    Article in journal (Refereed) Submitted
    Identifiers
    urn:nbn:se:uu:diva-91466 (URN)
    Available from: 2004-03-11 Created: 2004-03-11Bibliographically approved
    5. Synthesis and Conformational Analysis of Novel β-Hairpin mimetics. Factors Affecting Stability and Incorporation of a Photoswitchable Dipeptide Mimic
    Open this publication in new window or tab >>Synthesis and Conformational Analysis of Novel β-Hairpin mimetics. Factors Affecting Stability and Incorporation of a Photoswitchable Dipeptide Mimic
    Article in journal (Refereed) Submitted
    Identifiers
    urn:nbn:se:uu:diva-91467 (URN)
    Available from: 2004-03-11 Created: 2004-03-11Bibliographically approved
  • 259.
    Erdélyi, Máté
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Gogoll, Adolf
    Rapid Homogeneous-Phase Sonogashira Coupling Reactions Using Controlled Microwave Heating2001In: Journal of Organic Chemistry, Vol. 66, no 12, p. 4165-4169Article in journal (Refereed)
  • 260.
    Erdélyi, Máté
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Organic Chemistry.
    Gogoll, Adolf
    Rapid Microwave Promoted Sonogashira Coupling Reactions on Solid Phase2003In: Journal of Organic Chemistry, Vol. 68, no 16, p. 6431-6434Article in journal (Refereed)
    Abstract [en]

    A microwave-enhanced, rapid, and efficient solidphase version of the Sonogashira reaction is presented. It has been applied to the coupling of aryl iodides and bromides with various acetylene derivatives giving excellent yields in 15 to 25 min. The scopes of homogeneous, solventless, and solid-phase conditions for Sonogashira coupling of aryl halides are compared.

  • 261.
    Erdélyi, Máté
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Langer, Vratislav
    Karlén, Anders
    Gogoll, Adolf
    Insight into β-Hairpin Stability: A Structural and Thermodynamic Study of Diastereomeric β-Hairpin Mimetics2002In: New Journal of Chemistry, Vol. 26, p. 834-843Article in journal (Refereed)
  • 262.
    Erdélyi, Máté
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Nurbo, Johanna
    Niklason, Ida
    Karlén, Anders
    Gogoll, Adolf
    Synthesis and Conformational Analysis of Novel Stibene-type PeptidomimeticsArticle in journal (Refereed)
  • 263.
    Erdélyi, Máté
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Persson, Åsa
    Karlén, Anders
    Gogoll, Adolf
    Synthesis and Conformational Analysis of Novel β-Hairpin mimetics. Factors Affecting Stability and Incorporation of a Photoswitchable Dipeptide MimicArticle in journal (Refereed)
  • 264.
    Ericsson, C
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Engman, L
    Diastereocontrol by trialkylaluminums in the synthesis of tetrahydrofurans via radical cyclization2001In: ORGANIC LETTERS, ISSN 1523-7060, Vol. 3, no 22, p. 3459-3462Article in journal (Refereed)
    Abstract [en]

    [GRAPHICS] The influence of various Lewis acids in the radical cyclization of beta -allyloxyalkyl phenyl selenides was investigated. Whereas the unperturbed cyclization afforded trans-2,4-disubstituted tetrahydrofurans as the major products (cis/trans app

  • 265.
    Ericsson, Cecilia
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Synthesis of Tetrahydrofuran and Pyrrolidine Derivatives Utilising Radical Reactions: Organochalcogenides in Reductive, Carbonylative and Group-Transfer Cyclisation2004Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis describes free-radical reactions for the construction of tetrahydrofuran and pyrrolidine derivatives. The studies are concerned with (i) diastereoselectivity in radical cyclisation, (ii) construction of tetrahydrofuran-3-ones and pyrrolidin-3-ones via radical carbonylation/cyclisation and (iii) synthesis of tetrahydrofuran derivatives via group-transfer cyclisation of organochalcogen compounds.

    (i) Diastereoselectivity in the synthesis of tetrahydrofuran derivatives via radical cyclisation was controlled by addition of Lewis acids. In the synthesis of 2,4-disubstitued tetrahydrofurans, the trans-isomer was formed as the major product in the unperturbed reaction. Upon addition of trialkylalumiums the diastereoselectivity was reversed. In a similar fashion, exo/endo-diastereoselectivity in the synthesis of bicyclic 2,3,4-trisubstituted tetrahydrofurans could also be controlled.

    (ii) Procedures for construction of tetrahydrofuran-3-ones and pyrrolidin-3-ones were presented. Epoxides were ring-opened with benzeneselenolate or benzenetellurolate and the resulting β-hydroxyalkyl phenyl chalcogenides were vinylated using ethyl propiolate/NMM or E-1,2-bis(phenylsulfonyl)ethylene/NaH. The corresponding nitrogen analogues were accessed by N-vinylation of aziridines followed by benzeneselenolate ring-opening. The two types of organochalcogen radical precursors were then treated with TTMSS/AIBN under an atmosphere of carbon monoxide (80 atm) to afford tetrahydrofuran-3-ones and pyrrolidin-3-ones, respectively, in high yields.

    (iii) Microwaves were found to induce group-transfer cyclisation of β-allyloxyalkyl aryl chalcogenides. Short time heating (3-10 min) at 250 oC in ethylene glycol was required to obtain tetrahydrofuran derivatives in 60-91% yield.

    List of papers
    1. Diastereocontrol by Trialkylaluminums in the Synthesis of Tetrahydrofurans via Radical Cyclisation
    Open this publication in new window or tab >>Diastereocontrol by Trialkylaluminums in the Synthesis of Tetrahydrofurans via Radical Cyclisation
    2001 In: Organic Letters, Vol. 3, p. 3459-Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-91437 (URN)
    Available from: 2004-02-26 Created: 2004-02-26Bibliographically approved
    2. Construction of Tetrahydrofuran-3-ones from Readily Available Organochalcogen Precursors via Radical Carbonylation/Reductive Cyclization
    Open this publication in new window or tab >>Construction of Tetrahydrofuran-3-ones from Readily Available Organochalcogen Precursors via Radical Carbonylation/Reductive Cyclization
    2002 In: Organic Letters, Vol. 4, p. 3-Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-91438 (URN)
    Available from: 2004-02-26 Created: 2004-02-26Bibliographically approved
    3. Radical Carbonylation/Reductive Cyclization for the Construction of Tetrahydrofuran-3-ones and Pyrrolidin-3-ones
    Open this publication in new window or tab >>Radical Carbonylation/Reductive Cyclization for the Construction of Tetrahydrofuran-3-ones and Pyrrolidin-3-ones
    2003 In: Journal of Organic Chemistry, Vol. 68, p. 8386-Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-91439 (URN)
    Available from: 2004-02-26 Created: 2004-02-26Bibliographically approved
    4. Microwave-Assisted Group-Transfer Cyclisation of Organotellurium Compounds
    Open this publication in new window or tab >>Microwave-Assisted Group-Transfer Cyclisation of Organotellurium Compounds
    Article in journal (Refereed) Submitted
    Identifiers
    urn:nbn:se:uu:diva-91440 (URN)
    Available from: 2004-02-26 Created: 2004-02-26Bibliographically approved
  • 266.
    Ericsson, Cecilia
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Engman, Lars
    Diastereocontrol by Trialkylaluminums in the Synthesis of Tetrahydrofurans via Radical Cyclisation2001In: Organic Letters, Vol. 3, p. 3459-Article in journal (Refereed)
  • 267.
    Ericsson, Cecilia
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Engman, Lars
    Microwave-Assisted Group-Transfer Cyclisation of Organotellurium CompoundsArticle in journal (Refereed)
  • 268.
    Ericsson, Cecilia
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Organisk kemi.
    Engman, Lars
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Microwave-Assisted Group-Transfer Cyclization of Organotellurium Compounds2004In: The Journal of Organic Chemistry, Vol. 69, no 15, p. 5143-5146Article in journal (Refereed)
    Abstract [en]

    Primary- and secondary-alkyl aryl tellurides, prepared by arenetellurolate ring-opening of epoxides/O-allylation, were, found to undergo rapid (3-10 min) group-transfer cyclization to afford tetrahydrofuran derivatives in 60-74% yield when heated in a microwave cavity at 250C in ethylene glycol or at 180C in water. To go to completion, similar transformations had previously required extended photolysis in refluxing benzene containing a substantial amount of hexabutylditin. The only drawback of the microwave-assisted process was the loss in diastereoselectivity wich is a consequence of the higher reaction temperature. Substitution in the Te-aryl moiety of the secondary-alkyl aryl tellurides (4-OMe, 4-H, 4-CF3) did not affect the outcome of the group-transfer reaction in ethylene glycol. However, at lower temperature, using water as a solvent, the CF3 derivative failed to react. The microwave-assisted grouptransfer cyclization was extended to benzylic but not to primary- and secondary-alkyl phenyl selenides.

  • 269.
    Ericsson, D.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Bergquist, J.
    Ultrasensitive MALDI-TOF MS with picoliter volume sample handling2002In: Mass spectrometry and Hyphenated Techniques in Neuropeptide Research, John Wiley & Sons, N.Y. , 2002, Vol. Chapter 9, p. 235-255Chapter in book (Refereed)
  • 270.
    Ericsson, D
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Ekstrom, S
    Nilsson, J
    Bergquist, J
    Marko-Varga, G
    Laurell, T
    Downsizing proteolytic digestion and analysis using dispenser-aided sample handling and nanovial matrix-assisted laser/desorption ionization-target arrays2001In: PROTEOMICS, ISSN 1615-9853, Vol. 1, no 9, p. 1072-1081Article in journal (Refereed)
    Abstract [en]

    An efficient technique for enzymatic digestion of proteins in nanovial arrays and identification by peptide mass fingerprinting using matrix-assisted laser desorption/ionization (MALDI-MS) is presented in this work. Through dispensing of a protein solutio

  • 271.
    Ericsson, D.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Ekström, S.Nilsson, J.Bergquist, JonasUppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.Marko-Varga, G.Laurell, T.
    Dispenser-aided nanodigestion for rapid protein identification in MALDI-TOF nanovial arrays2001Conference proceedings (editor) (Other academic)
  • 272.
    Ericzon, Christina
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Determination of Lead and Selenium and Speciation of Selenium in Different End Products from a Garbage Incinerator1989Licentiate thesis, monograph (Other academic)
  • 273. Eriksson, A
    et al.
    Nyholm, L
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    A comparative study of the oxidation of 3-, 4- and 5-aminosalicylic acids at glassy carbon electrodes1998In: ELECTROANALYSIS, ISSN 1040-0397, Vol. 10, no 3, p. 198-203Article in journal (Refereed)
    Abstract [en]

    The oxidation behavior of 3-aminosalicylic acid (3-ASA), 4-aminosalicylic acid (4-ASA) and 5-aminosalicyclic acid (5-ASA), the active part of the drugs Sulphasalazine and Dipentum for the treatment of ulcerative colitis, has been compared. The redox beha

  • 274.
    Eriksson, A
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Nyholm, L
    A comparison of the electrochemical properties of some azosalicylic acids at glassy carbon electrodes by cyclic and hydrodynamic voltammetry1999In: ELECTROCHIMICA ACTA, ISSN 0013-4686, Vol. 44, no 23, p. 4029-4040Article in journal (Refereed)
    Abstract [en]

    The electrochemical properties of a number of azosalicylic acid derivatives have been compared at glassy carbon electrodes using cyclic and hydrodynamic voltammetry. The reduction of all studied compounds, except one, was found to be irreversible giving

  • 275.
    Eriksson, A
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Nyholm, L
    Coulometric and spectroscopic investigations of the oxidation and reduction of some azosalicylic acids at glassy carbon electrodes2001In: ELECTROCHIMICA ACTA, ISSN 0013-4686, Vol. 8, no 496, p. 1113-1129Article in journal (Refereed)
    Abstract [en]

    Constant potential coulometry in combination with cyclic voltammetry, UV-Vis, H-1 and C-13 NMR spectroscopy were used to identify the oxidation and reduction products for some structurally similar azosalicylic acids, including the azosalicylic drugs Sulfa

  • 276.
    Eriksson, A
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Nyholm, L
    Electrochemical detection of disodium 3,3 '-azobis-(6-hydroxy-)benzoate (olsalazine sodium)1997In: ELECTROANALYSIS, ISSN 1040-0397, Vol. 9, no 16, p. 1291-1293Article in journal (Refereed)
    Abstract [en]

    Electrochemical detection of disodium 3,3'-azobis-(6-hydroxy-)benzoate, olsalazine sodium, in reversed phase Liquid chromatography is shown to provide a detection limit of 40 fmol and a linear range extending up to 4 nmol for an injection volume of 20 mu

  • 277.
    Eriksson, Alf
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Carbon Electrodes for Analysis of Organic Compounds with some Applications1992Licentiate thesis, monograph (Other academic)
  • 278.
    Eriksson, Alf
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Voltammetric properties of olsalazine sodium and some related compounds2001Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The voltammetric properties of Olsalazine sodium, seven other azosalicylic acids and the azoxy analogue of Olsalazine sodium have been studied in aqueous solutions mainly by cyclic voltammetry and constant potential coulometry. It was found that these compounds can all be both reduced and oxidised at a glassy carbon electrode. The reduction and oxidation potentials of the compounds were dependent on the pH and the structure of the compounds. All compounds, except 4,4'-azobis-(2-hydroxybenzoic acid), were reduced to the corresponding amino salicylic acids in a 4 e-, 4 H+ reaction, as shown by spectrophotometric and voltammetric investigations of the reduced solutions. A further electrochemical characterisation of the formed reduction products 3-, 4- and 5-aminosalicylic acid was also carried out.

    It was found that the oxidation of the investigated azo compounds occurs according to two different pathways. Compounds with, at the most one hydroxyl group in the 2- or 4- position were shown to be irreversibly oxidised while Olsalazine sodium, its azoxy analogue and 2-hydroxy-5-[(3'-carboxy-2'-hydroxyphenyl)azo]benzoic acid disodium salt were oxidised in a reversible 2e-, 2H+ reaction. The oxidation product of Olsalazine sodium was characterised by UV/VIS and NMR spectroscopic methods and a structure for the oxidation product was proposed. The oxidative properties of Olsalazine sodium were also utilised to determine nM concentrations of this compound by liquid chromatography with electrochemical detection (LCEC).

  • 279.
    Eriksson, Anders
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Hermansson, Kersti
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Analysis of the thermal parameters of the water molecule in crystalline hydrates studied by neutron diffraction1983In: Acta Crystallographica Section B: Structural Science, ISSN 0108-7681, E-ISSN 1600-5740, Vol. B39, p. 703-711Article in journal (Refereed)
    Abstract [en]

    A survey is given of the thermal parameters of 150 water molecules in crystalline hydrates determined by neutron diffraction. The accuracy of the thermal parameters has been examined and rigid-bond tests revealed systematic errors for approximately 25% of the molecules. Considering only the most precise and accurate studies, good agreement is obtained between vibrational amplitudes derived from diffraction and spectroscopy. The influence of the immediate environment on the vibrations of the water molecule has also been investigated. A positive correlation is found between H...O hydrogen-bond distances and librational amplitudes. The coordination geometry around the O atom is shown to influence the vibrational amplitudes of the O atom.

  • 280. Eriksson, Anders
    et al.
    Hermansson, Kersti
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Lindgren, Jan
    Thomas, John O.
    The use of spectroscopic data in the least-squares refinement of diffraction-obtained structure parameters. An example: K 2C 2O 4.H 2O1982In: Acta Crystallogr. A, Cryst. Phys. Diffr. Theor. Gen. Crystallogr. (Denmark), ISSN 0567-7394, Vol. A38, p. 138-142Article in journal (Refereed)
    Abstract [en]

    A method is presented in which parameters obtained from vibrational spectroscopy are used in the least-squares refinement of positional and thermal parameters obtained from diffraction data. The method involves the calculation of those contributions to the temperature factors not well described by the second-rank tensor approximation conventionally used in crystal structure determinations. Expressions are given for the temperature-factor contributions from vibrational motion on an arc and from anharmonic linear motion. The method is applied to the water molecule in dipotassium oxalate monohydrate, 2K +.C 2O 4-.H 2O. Refinements using vibrational data are compared with a conventional refinement; the latter are shown to give considerable systematic errors in the geometrical parameters for the water molecule.

  • 281.
    Eriksson, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Organic Chemistry.
    Synthesis of 11C-labelled Alkyl Iodides: Using Non-thermal Plasma and Palladium-mediated Carbonylation Methods2006Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Compounds labelled with 11C (β+, t1/2 = 20.4 min) are used in positron emission tomography (PET), which is a quantitative non-invasive molecular imaging technique. It utilizes computerized reconstruction methods to produce time-resolved images of the radioactivity distribution in living subjects.

    The feasibility of preparing [11C]methyl iodide from [11C]methane and iodine via a single pass through a non-thermal plasma reactor was explored. [11C]Methyl iodide with a specific radioactivity of 412 ± 32 GBq/µmol was obtained in 13 ± 3% decay-corrected radiochemical yield within 6 min via catalytic hydrogenation of [11C]carbon dioxide (24 GBq) and subsequent iodination, induced by electron impact.

    Labelled ethyl-, propyl- and butyl iodide was synthesized, within 15 min, via palladium-mediated carbonylation using [11C]carbon monoxide. The carbonylation products, labelled carboxylic acids, esters and aldehydes, were reduced to their corresponding alcohols and converted to alkyl iodides. [1-11C]Ethyl iodide was obtained via palladium-mediated carbonylation of methyl iodide with a decay-corrected radiochemical yield of 55 ± 5%. [1-11C]Propyl iodide and [1-11C]butyl iodide were synthesized via the hydroformylation of ethene and propene with decay-corrected radiochemical yields of 58 ± 4% and 34 ± 2%, respectively. [1-11C]Ethyl iodide was obtained with a specific radioactivity of 84 GBq/mmol from 10 GBq of [11C]carbon monoxide. [1-11C]Propyl iodide was synthesized with a specific radioactivity of 270 GBq/mmol from 12 GBq and [1-11C]butyl iodide with 146 GBq/mmol from 8 GBq.

    Palladium-mediated hydroxycarbonylation of acetylene was used in the synthesis of [1-11C]acrylic acid. The labelled carboxylic acid was converted to its acid chloride and subsequently treated with amine to yield N-[carbonyl-11C]benzylacrylamide. In an alternative method, [carbonyl-11C]acrylamides were synthesized in decay-corrected radiochemical yields up to 81% via palladium-mediated carbonylative cross-coupling of vinyl halides and amines. Starting from 10 ± 0.5 GBq of [11C]carbon monoxide, N-[carbonyl-11C]benzylacrylamide was obtained in 4 min with a specific radioactivity of 330 ± 4 GBq/µmol.

    List of papers
    1. [C-11]methyl iodide from [C-11]methane and iodine using a non-thermal plasma method
    Open this publication in new window or tab >>[C-11]methyl iodide from [C-11]methane and iodine using a non-thermal plasma method
    2006 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 49, no 13, p. 1177-1186Article in journal (Refereed) Published
    Abstract [en]

    A method and an apparatus for preparing [C-11]methyl iodide from [C-11]methane and iodine in a single pass through a non-thermal plasma reactor has been developed. The plasma was created by applying high voltage (400 V/31 kHz) to electrodes in a stream of helium gas at reduced pressure. The [C-11]methane used in the experiments was produced from [C-11]carbon dioxide via reduction with hydrogen over nickel. [C-11]methyl iodide was obtained with a specific radioactivity of 412 +/- 32 GBq/mu mol within 6 min from approximately 24 GBq of [C-11]carbon dioxide. The decay corrected radiochemical yield was 13 +/- 3% based on [C-11]carbon dioxide at start of synthesis. [C-11]Flumazenil was synthesized via a N-alkylation with the prepared [C-11]methyl iodide.

    Keyword
    [C-11]methyl iodide, [C-11]methane, non-thermal plasma, specific radioactivity
    National Category
    Chemical Sciences
    Identifiers
    urn:nbn:se:uu:diva-94929 (URN)10.1002/jlcr.1135 (DOI)000242796700006 ()
    Available from: 2006-10-05 Created: 2006-10-05 Last updated: 2017-12-14Bibliographically approved
    2. Synthesis of [1-11C]ethyl iodide from carbon monoxide and its application in alkylation reactions
    Open this publication in new window or tab >>Synthesis of [1-11C]ethyl iodide from carbon monoxide and its application in alkylation reactions
    2004 (English)In: Journal of Labelled Compounds and Radiopharmaceuticals, ISSN 0362-4803, Vol. 47, no 11, p. 723-731Article in journal (Refereed) Published
    National Category
    Natural Sciences
    Identifiers
    urn:nbn:se:uu:diva-94930 (URN)
    Available from: 2006-10-05 Created: 2006-10-05 Last updated: 2015-09-24
    3. Synthesis of [1-C-11]propyl and [1-C-11]butyl iodide from [C-11]carbon monoxide and their use in alkylation reactions
    Open this publication in new window or tab >>Synthesis of [1-C-11]propyl and [1-C-11]butyl iodide from [C-11]carbon monoxide and their use in alkylation reactions
    2006 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 49, no 12, p. 1105-1116Article in journal (Refereed) Published
    Abstract [en]

    A method to prepare [1-C-11]propyl iodide and [1-C-11]butyl iodide from [C-11]carbon monoxide via a three step reaction sequence is presented. Palladium mediated formylation of ethene with [C-11]carbon monoxide and hydrogen gave [1-C-11]propionaldehyde and [1-C-11]propionic acid. The carbonylation products were reduced and subsequently converted to [1-C-11]propyl iodide. Labelled propyl iodide was obtained in 58 +/- 4% decay corrected radiochemical yield and with a specific radioactivity of 270 +/- 33 GBq/mu mol within 15 min from approximately 12 GBq of [C-11]carbon monoxide. The position of the label was confirmed by C-13-labelling and C-13-NMR analysis. [1-C-11]Butyl iodide was obtained correspondingly from propene and approximately 8 GBq of [C-11]carbon monoxide, in 34 +/- 2% decay corrected radiochemical yield and with a specific radioactivity of 146 +/- 20 GBq/mu mol. The alkyl iodides were used in model reactions to synthesize [O-propyl-1-C-11]propyl and [O-butyl-1-C-11]butyl benzoate. Propyl and butyl analogues of etomidate, a (beta-11-hydroxylase inhibitor, were also synthesized.

    Keyword
    [C-11]carbon monoxide, [1-C-11]propyl iodide, [1-C-11]butyl iodide, carbonylation, formylation, alkylation
    National Category
    Chemical Sciences
    Identifiers
    urn:nbn:se:uu:diva-94931 (URN)10.1002/jlcr.1119 (DOI)000242335900009 ()
    Available from: 2006-10-05 Created: 2006-10-05 Last updated: 2017-12-14Bibliographically approved
    4. Synthesis of [11C]/[13C]acrylamides by palladium-mediated carbonylation
    Open this publication in new window or tab >>Synthesis of [11C]/[13C]acrylamides by palladium-mediated carbonylation
    2007 (English)In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, no 3, p. 455-461Article in journal (Refereed) Published
    Abstract [en]

    Two methods are presented for the synthesis of acrylamides labelled with C-11 (beta(+), t(1/2) = 20.4 min) and C-11 in the carbonyl position. In the first method, [1-C-11]acrylic acid is synthesised from [C-11]carbon monoxide by palladium-mediated hydroxy-carbonylation of acetylene. The labelled carboxylic acid is converted into the acyl chloride and subsequently treated with amine to yield N-benzyl[carbonyl(11)C]acrylamide, The second method utilizes [C-11]carbon monoxide in a palladium-mediated carbonylative cross-coupling of vinyl halides and amines. A higher radiochemical yield is achieved with the latter method and the amount of amine needed is decreased to 1/20. The C-11-labelled acrylamides were isolated in up to 81 % decay-corrected radiochemical yield. Starting from 10 +/- 0.5GBq of [C-11]carbon monoxide, N-benzyl[carbonyl-C-11]acrylamide was obtained in 4 min with a specific radioactivity of 330 +/- 4 GBq mu mol-(1). Co-labelling with C-11 and C-13 enabled confirmation of the labelled position by C-13 NMR spectroscopy.

    Keyword
    Carbonylation, Amides, Carbon monoxide, Isotopic labelling, Carbon-11, 11C, PET
    National Category
    Chemical Sciences
    Research subject
    Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-98592 (URN)10.1002/ejoc.200600700 (DOI)000243600100007 ()
    Available from: 2009-02-27 Created: 2009-02-27 Last updated: 2017-12-13Bibliographically approved
    5. [1-11C]Ethyl iodide and [1-11C]propyl iodide in the synthesis of two potential NK1-receptor ligands and initial PET-imaging
    Open this publication in new window or tab >>[1-11C]Ethyl iodide and [1-11C]propyl iodide in the synthesis of two potential NK1-receptor ligands and initial PET-imaging
    Show others...
    (English)Manuscript (Other academic)
    National Category
    Medicinal Chemistry
    Identifiers
    urn:nbn:se:uu:diva-94933 (URN)
    Available from: 2006-10-05 Created: 2006-10-05 Last updated: 2018-01-13
  • 282.
    Eriksson, Jonas
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Organic Chemistry.
    Antoni, Gunnar
    Långström, Bengt
    Synthesis of [1-11C]ethyl iodide from carbon monoxide and its application in alkylation reactions2004In: Journal of Labelled Compounds and Radiopharmaceuticals, ISSN 0362-4803, Vol. 47, no 11, p. 723-731Article in journal (Refereed)
  • 283.
    Eriksson L, Beletskaya I.P, Bregadze V.I, Sivaev I.B, Sjöberg S.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Palladium-catalyzed cross-coupling reactions of arylboronic acids and 2-I-p-carborane2002In: Journal of Organometallic Chemistry, no 657, p. 267-272Article in journal (Other scientific)
  • 284.
    Eriksson L, Winberg K-J, Claro R.T, Sjöberg S.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Palladium-catalyzed Heck reactions of styrene derivatives and 2-I-p-carborane2003In: J. Org. ChemArticle in journal (Other scientific)
  • 285. Eriksson, Lars
    et al.
    Werner, Per-Erik
    Berger, Rolf
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Oorganisk kemi.
    Meerschaut, Alain
    Structure refinement of TlCu7Se4 from X-ray powder profile data1991In: Journal of Solid State Chemistry, Vol. 90, p. 61-68Article in journal (Refereed)
    Abstract [en]

    The structure of TlCu7Se4 (synthetic crookesite) has been refined from X-ray powder data using the Rietveld technique. The compound is isostructural with NH4Cu7S4 and TlCu7S4, although successful refinements from two independent data sets occurred in I4/m rather than I -4 previously suggested for this structure type. Positional parameters of natural crookesite were refined from slightly inferior single-crystal data to R(F)= 8.5%.

  • 286.
    Eriksson, Ludvig
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Transition Metal Mediated Transformations of Carboranes2003Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis describes the use of copper and palladium to mediate transformations of carboranes, especially p-carborane.

    1-(1-p-carboranyl)-N-methyl-N-(2-butyl)-3-isoquinolinecarboxamide, a carborane containing analogue of the peripheral benzodiazepine receptor (PBR) ligand PK11195, has been synthesised. A key step in the reaction is the copper (I) mediated coupling of p-carborane with ethyl 1-bromo-isoquinoline-3-carboxylate.

    p-Carborane has been arylated on the 2-B-atom in high yields, using the Suzuki–Miyaura reaction. Thus the reaction between 2-I-p-carborane and various arylboronic acids [1-naphthyl-, phenyl-, 4-MeO-C6H4-, 3-CH3CONH-C6H4-, 4-NC-C6H4-, 3-NO2-C6H4-], gave the corresponding 2-aryl-p-carboranes in DME solution when reacted in the presence of cesium fluoride and the catalytic Pd2(dba)3–dppb system. Under the same conditions, the boron-boron bond forming reaction of two p-carboranylboronic esters (2-[(pinacolato)boron]-p-carborane and 2-[(neopentyl glycolato)boron]-p-carborane) was also shown feasible.

    p-Carborane has been vinylated on the 2-B-atom in high yields by use of the Heck reaction. The coupling between 2-I-p-carborane and various styrenes [4-H-, 4-C6H4-, 4-Cl , 4-Br-, 4-NO2-, 4-CH3O- and 4 CH3 ] resulted in the formation of the correspondingtrans-β-(2-B-p-carboranyl) styrene in DMF solution when reacted in the presence of silver phosphate and the palladacycle Herrmann´s catalyst. The reaction was shown to proceed at higher rate with electron rich than with electron deficient olefins.

    The feasibility of palladium-catalysed isotopic exchange of an iodinated closo-carborane with a radioisotope of iodine has been studied. 2-I-p-carborane was selected as a model compound. It was shown, that such isotopic exchange is possible and provides a high yield (83 ± 4.2 %) during 40 min long reaction. The reaction conditions were optimised, and it was demonstrated that presence of the tetra n-butylammonium hydrogensulphate is important in order to stabilise catalyst and provide reproducibility of labelling. In this work we have modified the methodology and extended the application to a wider range of iodinated carboranes. By the use of Herrmann’s catalyst in toluene at 100 °C this [125I]-iodide labelling could be improved and extended. 2-I-p- 9-I-m-, 9-I-o-, 3-I-o-carborane, 1-phenyl-3-I-o-carborane and 1,2-diphenyl-3-I-o-carborane could be [125I]-iodide labelled in high to excellent yields within 5 minutes.This reported palladium catalyzed radio-iodination of the uncharged closo-carboranes might find use in pharmacokinetic studies of carborane derivatives.

  • 287. Eriksson, Ludvig
    et al.
    Winberg, Karl Johan
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Claron, Rodrigo T.
    Sjöberg, Stefan
    Palladium-catalysed Heck reactions of styrene derivatives and 2-I-p-carborane2003In: Journal of Organic Chemistry, Vol. 68, no 9, p. 3569-3573Article in journal (Refereed)
  • 288.
    Eriksson, P
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Engman, L
    An Antioxidant Composition Comprising Organic Tellurium Compound, Thiol Reducing Agent and Hindered Phenols2003In: PCT Int. Appl. WO, Vol. 03, no 52, p. 026-Article in journal (Refereed)
  • 289. Eriksson, Per
    et al.
    Engman, Lars
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Organisk kemi.
    Lind, Johan
    Merényi, Gabor
    Aqueous Phase One-Electron Reduction of Sulfonium, Selenonium and Telluronium Salts2005In: Eur. J. Org. Chem., p. 701-705Article in journal (Refereed)
    Abstract [en]

    Triorganylsulfonium, -selenonium and -telluronium salts were reduced by carbon dioxide radical anions/solvated electrons produced in aqueous solution by radiolysis. The radical expulsion accompanying reduction occurred with the expected leaving group propensities (benzyl > secondary alkyl> primary alkyl> methy> phenyl), although greater than expected loss of the phenyl group was often observed. Diorganyl chalcogenides formed in the reductions were conveniently isolated by extraction with an organic solvent. Product yields based on the amount of reducing radicals obtained from the y-source were often higher than stoichiometric (up to 1800%) in the reduction of selenonium an dtelluronium compounds; it is likely that this result can be accounted for in terms of a chain reaction with carbon-centred radicals/formate serving as the chain transfer agent. The product distribution was essentially independent of the reducing species for diphenyl alkyl telluronium salts, whereas significant variations were seen for some of the corresponding selenonium salts. This would suggest the intermediacy of telluranyl radicals in the one-electron reduction of telluronium salts. However, pulse radiolysis experiments indicated that the lifetimes of such a species (the triphenyltelluranyl radical) would have to be less than 1 us.

  • 290.
    Fagerlund, Amelie
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Shanks, David
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Sunnerheim, Kerstin
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Engman, Lars
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Frisell, Håkan
    Protective Effects of Synthetic and Naturally Occurring Antioxidants in Pulp Products2003In: Nordic Pulp & Paper Research Journal, ISSN 0283-2631, E-ISSN 2000-0669, Vol. 18, no 2, p. 176-181Article in journal (Refereed)
    Abstract [en]

    Various types of natural and synthetic antioxidants when added to handsheets of pulp in low concentrations (0.2% weight%) could significantly reduce the emission of hexanal. The most efficient compounds caused a 90% reduction after eight weeks. Their capacity to inhibit brightness reversion was limited.

  • 291.
    Fagerlund, Amelie
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Organic Chemistry.
    Sunnerheim, Kerstin
    Dimberg, Lena H.
    Radical-scavenging and antioxidant activity of avenanthramides2009In: Food Chemistry, ISSN 0308-8146, E-ISSN 1873-7072, Vol. 113, no 2, p. 550-556Article in journal (Refereed)
    Abstract [en]

    Avenanthramides are amides of cinnamoyl-anthranilic acids and, among cereals, are exclusively found in oats. This study investigated the structure-antioxidant activities of 15 avenanthramides with different substitution patterns in the two aromatic rings, seven of which were new avenanthramides synthesised and characterised in this study. Radical-scavenging activity was tested as reactivity towards 1,1-diphenyl-2-picrylhydrazyl (DPPH-). The activity increased with the number of radical-stabilising groups ortho to the phenolic hydroxy group. Both aromatic rings were independently important for activity, while conjugation across the amide bond was of minor importance. Antioxidant activity was determined as inhibition of linoleic acid oxidation. In contrast to the radical-scavenging activity, antioxidant activity was observed for most avenanthramides, and also for compounds with only one hydroxy group in either of the aromatic rings. Compared with alpha-tocopherol, the avenanthramides protected linoleic acid from oxidation to a smaller extent initially, but the effect lasted for a longer time.

  • 292.
    Fast, K J
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
    Bergström, M
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
    Hedberg, E
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
    Cheng, A
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Organic Chemistry.
    Lu, L
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
    Wu, F
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
    Bergström, E
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
    Tolmachev, Vladimir
    Långström, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Organic Chemistry.
    76-Br-bromodeoxyuridine marker with PET-preclinical validation studies1997In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 40, no 5, p. 391-393Article in journal (Refereed)
  • 293. Fasth, Karl-Johan
    et al.
    Antoni, Gunnar
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Långström, Bengt
    Asymmetric synthesis of L-[3-11C]alanine and L-[3-11C]phenylalanine by a phase-transfer alkylation reaction.1988In: J. Chem. Perk. Trans. 1, p. 3081-Article in journal (Refereed)
  • 294.
    Feldman, H
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Hartvig, P
    Wiklund, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Doucette, A-M
    Antoni, Gunnar
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Gee, A
    Uhlin, J
    Langstrom, B
    Regional distribution of 11C-labeled lidocaine, bupivacaine, and ropivacaine in the heart, lungs, and skeletal muscle of pigs studied with positron emission tomography.1997In: Biopharm. Drug Dispos., Vol. 18, p. 151-Article in journal (Refereed)
  • 295.
    Fernandez, F.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Vadillo, J.
    Kimmel, J.
    Wetterhall, M.
    Hadamar transform time-of-flight mass spectrometry: A high-speed detector for capillary-format separations2002In: Anal. Chem., no 74, p. 1611-1617Article in journal (Refereed)
  • 296.
    Fernández F.M., Rodriguez N., Vadillo J.M., Wetterhall M., Markides K.E., Engelke F., Kimmel J.R., Zare R.N.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Evaluation of the signal to noise ratio in a Hadamard transform time-of-flight mass spectrometer2001In: J. of American Society for Mass Spectrometry, Vol. 12, no 12, p. 1302-1311Article in journal (Refereed)
  • 297.
    Fogarty, H. A.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Tsuji, H.
    David, D. E.
    Ottosson, C-H.
    Ehara, M.
    Nakatsuji, H.
    Tamao, K.
    Michl, J.
    Peralkylated Tetrasilanes: Conformational Dependence of the Photoelectron Spectrum2002In: J. Phys. Chem. A;, no 106(10), p. 2369-2373Article in journal (Other scientific)
  • 298. Forngren, Benita H
    et al.
    Samskog, Jenny
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Analytical Chemistry.
    Gustavsson, Sven Åke
    Tyrefors, Niklas
    Markides, Karin E
    Långström, Bengt
    Reversed-phase ion-pair chromatography coupled to electrospray ionisation mass spectrometry by on-line removal of the counter-ions1999In: J Chromatogr A, Vol. 854, no 1-2, p. 155-162Article in journal (Refereed)
  • 299.
    Forngren, BH
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Samskog, J
    Gustavsson, SA
    Tyrefors, N
    Markides, KE
    Langstrom, B
    Reversed-phase ion-pair chromatography coupled to electrospray ionisation mass spectrometry by on-line removal of the counter-ions1999In: JOURNAL OF CHROMATOGRAPHY A, ISSN 0021-9673, Vol. 854, no 1-2, p. 155-162Article in journal (Refereed)
    Abstract [en]

    A strong anion-exchanger was used as a trapping column to perform on-line coupling of ion-pair chromatography with electrospray ionisation mass spectrometry. Ion-pairing reagents were used to retain polar analytes of low molecular mass away from the solv

  • 300.
    Forngren, BH
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Tyrefors, N
    Markides, KB
    Langstrom, B
    Determination of raclopride in human plasma by on-column focusing packed capillary liquid chromatography-electrospray ionisation mass spectrometry2000In: JOURNAL OF CHROMATOGRAPHY B, ISSN 0378-4347, Vol. 748, no 1, p. 189-195Article in journal (Refereed)
    Abstract [en]

    A packed capillary liquid chromatography-electrospray ionisation mass spectrometry method was developed for the quantitative determination of raclopride in human plasma samples. Plasma samples containing the drug and its isotopically substituted analogue

3456789 251 - 300 of 1047
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