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  • 1.
    Tang, Marc
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    A typology of classifiers and gender: From description to computation2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Categorization is one the most relevant tasks realized by humans during their life, as we consistently need to categorize the things and experience that we encounter. Such need is reflected in language via various mechanisms, the most prominent being nominal classification systems (e.g., grammatical gender such as the masculine/feminine distinction in French). Typological methods are used to investigate the underlying functions and structures of such systems, using a wide variety of cross-linguistic data to examine universality and variability. This analysis is itself a classification task, as languages are categorized and clustered according to their grammatical features. This thesis provides a cross-linguistic typological analysis of nominal classification systems and in parallel compares a number of quantitative methods that can be applied at different scales.

    First, this thesis provides an analysis of nominal classification systems (i.e., gender and classifiers) via the description of three languages with respectively gender, classifiers, and both. While the analysis of the first two languages are more of a descriptive nature and aligns with findings in the existing literature, the third language provides novel insights to the typology of nominal classification systems by demonstrating how classifiers and gender may co-occur in one language in terms of distribution of functions. Second, the underlying logic of nominal classification systems is commonly considered difficult to investigate, e.g., is there a consistent logic behind gender assignment in language? is it possible to explain the distribution of classifier languages of the world while taking into account geographical and genealogical effects? This thesis addresses the lack of arbitrariness of nominal classification systems at three different scales: The distribution of classifiers at the worldwide level, the presence of gender within a language family, and gender assignment at the language-internal level. The methods of random forests, phylogenetics, and word embeddings with neural networks are selected since they are respectively applicable at three different scales of research questions (worldwide, family-internal, language-internal).

    List of papers
    1. The lexical and discourse functions of grammatical gender in Marathi
    Open this publication in new window or tab >>The lexical and discourse functions of grammatical gender in Marathi
    2018 (English)In: Journal of South Asian languages and linguistics, ISSN 2196-0771, E-ISSN 2196-078X, Vol. 5, no 2Article in journal (Refereed) In press
    National Category
    General Language Studies and Linguistics
    Research subject
    Indology with Classical Sanscrit
    Identifiers
    urn:nbn:se:uu:diva-366417 (URN)10.1515/jsall-2018-0012 (DOI)
    Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2018-12-13
    2. Nominal classification in Assamese: An analysis of function
    Open this publication in new window or tab >>Nominal classification in Assamese: An analysis of function
    2019 (English)In: Nominal Classification in Asia: Functional and diachronic perspectives / [ed] Marc Tang and Marcin Kilarski, John Benjamins Publishing Company, 2019Chapter in book (Refereed)
    Place, publisher, year, edition, pages
    John Benjamins Publishing Company, 2019
    National Category
    General Language Studies and Linguistics
    Identifiers
    urn:nbn:se:uu:diva-366419 (URN)
    Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2018-11-21
    3. Functions of gender and numeral classifiers in Nepali
    Open this publication in new window or tab >>Functions of gender and numeral classifiers in Nepali
    (English)In: Poznan Studies in Contemporary Linguistics, ISSN 1732-0747, E-ISSN 1897-7499Article in journal (Refereed) Submitted
    National Category
    General Language Studies and Linguistics
    Identifiers
    urn:nbn:se:uu:diva-366473 (URN)
    Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2018-11-21
    4. Numeral base, numeral classifier, and noun: Word order harmonization
    Open this publication in new window or tab >>Numeral base, numeral classifier, and noun: Word order harmonization
    (English)In: Language and linguistics/Yuyan Ji Yuyangxue, ISSN 1606-822X, E-ISSN 2309-5067, Vol. 22, no 1Article in journal (Refereed) In press
    National Category
    General Language Studies and Linguistics
    Identifiers
    urn:nbn:se:uu:diva-366474 (URN)
    Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2018-11-29
    5. Insights on the Greenberg-Sanches-Slobin Generalization: Quantitative typological data on classifiers and plural markers
    Open this publication in new window or tab >>Insights on the Greenberg-Sanches-Slobin Generalization: Quantitative typological data on classifiers and plural markers
    (English)In: Folia linguistica, ISSN 0165-4004, E-ISSN 1614-7308Article in journal (Refereed) In press
    National Category
    General Language Studies and Linguistics
    Identifiers
    urn:nbn:se:uu:diva-366476 (URN)
    Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2018-11-21
    6. Word order of numeral classifiers and numeral bases: Harmonization by multiplication
    Open this publication in new window or tab >>Word order of numeral classifiers and numeral bases: Harmonization by multiplication
    (English)In: Language Typology and Universals, ISSN 1867-8319, E-ISSN 2196-7148Article in journal (Refereed) In press
    National Category
    General Language Studies and Linguistics
    Identifiers
    urn:nbn:se:uu:diva-366477 (URN)
    Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2018-11-21
    7. A Statistical Explanation of the Distribution of Sortal Classifiers in Languages of the World via Computational Classifiers
    Open this publication in new window or tab >>A Statistical Explanation of the Distribution of Sortal Classifiers in Languages of the World via Computational Classifiers
    2018 (English)In: Journal of Quantitative Linguistics, ISSN 0929-6174, E-ISSN 1744-5035Article in journal (Refereed) Published
    Abstract [en]

    Previous studies demonstrate that morphosyntactic plural markers and the structure of numeral systems have individually strong predictive power with regard to the usage of sortal classifiers in languages. We use these two factors as explanatory variables to train the computational classifier of random forests and evaluate the accuracy of their predictive power when selecting the existence/absence of sortal classifiers as response variable. Our results show that these two factors result in an excellent discrimination performance of random forests, even when taking into account sortal classifiers as an areal feature. However, the correlation between morphosyntactic plural markers and multiplicative bases is weaker than the correlation between sortal classifiers and plural markers plus multiplicative bases. We are thus able to provide novel insights with regard to probabilistic universals on sortal classifiers, and suggest an innovative cross-disciplinary approach to test the effect of implicational universals with computational methods.

    National Category
    General Language Studies and Linguistics Language Technology (Computational Linguistics)
    Research subject
    Linguistics
    Identifiers
    urn:nbn:se:uu:diva-362252 (URN)10.1080/09296174.2018.1523777 (DOI)
    Available from: 2018-10-03 Created: 2018-10-03 Last updated: 2018-11-21Bibliographically approved
    8. Measuring the phylogenetic signal of grammatical gender in Indo-Aryan languages
    Open this publication in new window or tab >>Measuring the phylogenetic signal of grammatical gender in Indo-Aryan languages
    (English)In: Language Dynamics and Change, ISSN 2210-5824, E-ISSN 2210-5832Article in journal (Refereed) Submitted
    National Category
    General Language Studies and Linguistics
    Identifiers
    urn:nbn:se:uu:diva-366596 (URN)
    Available from: 2018-11-21 Created: 2018-11-21 Last updated: 2018-11-23
    9. Linguistic information in word embeddings
    Open this publication in new window or tab >>Linguistic information in word embeddings
    2019 (English)In: Lecture notes in artificial intelligence / [ed] Randy Goebel, Yuzuru Tanaka, and Wolfgang Wahlster, Dordrecht: Springer, 2019Chapter in book (Refereed)
    Place, publisher, year, edition, pages
    Dordrecht: Springer, 2019
    National Category
    General Language Studies and Linguistics
    Identifiers
    urn:nbn:se:uu:diva-366478 (URN)
    Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2018-11-21
    10. Lexical and Morpho-syntactic Features in Word Embeddings: A Case Study of Nouns in Swedish
    Open this publication in new window or tab >>Lexical and Morpho-syntactic Features in Word Embeddings: A Case Study of Nouns in Swedish
    2018 (English)In: Proceedings of the 10th International Conference on Agents and Artificial Intelligence: Volume 2, Setubal: SciTePress, 2018, p. 663-674Chapter in book (Refereed)
    Place, publisher, year, edition, pages
    Setubal: SciTePress, 2018
    National Category
    General Language Studies and Linguistics
    Identifiers
    urn:nbn:se:uu:diva-351926 (URN)978-989-758-275-2 (ISBN)
    Available from: 2018-05-31 Created: 2018-05-31 Last updated: 2018-11-21Bibliographically approved
  • 2.
    Pavliuk, Mariia
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Accumulative Charge Separation in Photocatalysis: From Molecules to Nanoparticles2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Photochemical energy conversion into solar fuel involves steps of light absorption, charge separation and catalysis. Nature has taught us that the effective accumulation of redox equivalents and charge separation are the key steps in sunlight conversion. The focus of this thesis is to unveil photophysical and photochemical processes that lead to accumulative charge separation. The optimization of electron transfer process will be held by minimization of losses via recombination, and extension of the lifetime of the charge separated state by usage of the electron relay.

    The goal is to couple light induced electron transfer process with the multi-electron catalytic process of hydrogen evolution. In this regard, light harvesters (molecules, metal nanostructures) that generate at least two electrons per absorbed photon will be studied. Additionally, semiconductors that generate long-lived charge separated states are utilized to accumulate several redox equivalents necessary for hydrogen evolution.

    The hybrid systems produced by the combination of the advantageous properties of molecules, semiconductors, and metal nanoparticles are under the scope of investigation. Metal nanoparticles are advantageous because of their high absorption cross-section. The molecular linkers provide control and flexibility in tuning the connection between the light absorber and the electron relay. Semiconductor nanoparticles offer the desired charge separation properties via prolonging the lifetime sufficiently to perform photocatalysis.

    The detailed understanding, investigation and development of the hybrid systems is at the heart of the progress of photochemical solar fuel production.

    List of papers
    1. Ultra long-lived electron-hole separation within water-soluble colloidal ZnO nanocrystals: Prospective Applications For Solar Energy Production
    Open this publication in new window or tab >>Ultra long-lived electron-hole separation within water-soluble colloidal ZnO nanocrystals: Prospective Applications For Solar Energy Production
    Show others...
    2016 (English)In: Nano Energy, ISSN 2211-2855, Vol. 30, p. 187-192Article in journal (Refereed) Published
    Abstract [en]

    Zinc oxide was one of the first semiconductors used in dye-sensitized solar cells but its instability in aqueous media precludes its use for large-scale applications. Herein, we report on a novel ZnO nanocrystal material derived by an organometallic approach that is simultaneously stable and soluble in water due to its carboxylate oligoethylene glycol shell strongly anchored to the inorganic core by the head groups. The resulting unique inorganic core-organic shell interface also stabilizes the photo-generated hole, leading to a dramatic slowing down of charge recombination, which otherwise is a major hurdle in using nanostructured ZnO.

    Keywords
    Water-soluble colloidal ZnO nanocrystals, Ultra long-lived electron-hole separation, Advanced laser based spectroscopy, Solar energy production prospectus
    National Category
    Nano Technology Physical Chemistry
    Identifiers
    urn:nbn:se:uu:diva-314050 (URN)10.1016/j.nanoen.2016.09.045 (DOI)000390636100023 ()
    Funder
    Knut and Alice Wallenberg FoundationEU, European Research Council, 687008Swedish Research Council, 2015-03764
    Available from: 2017-02-06 Created: 2017-01-26 Last updated: 2018-12-17Bibliographically approved
    2. Hydrogen evolution with nanoengineered ZnO interfaces decorated using a beetroot extract and a hydrogenase mimic
    Open this publication in new window or tab >>Hydrogen evolution with nanoengineered ZnO interfaces decorated using a beetroot extract and a hydrogenase mimic
    Show others...
    2017 (English)In: Sustainable Energy & Fuels, ISSN 2398-4902, Vol. 1, p. 69-73Article in journal (Refereed) Published
    Abstract [en]

    Herein, we report a nano-hybrid photo-system based on abundant elements for H2 production with visible light. The photo-system's proficiency relates to the novel ZnO nanocrystals employed. The ZnO carboxylate oligoethylene glycol shell enhances charge separation and accumulates reactive electrons for the photocatalytic process. 

    Place, publisher, year, edition, pages
    Royal Society of Chemistry, 2017
    Keywords
    H2 evolution
    National Category
    Physical Chemistry Engineering and Technology
    Research subject
    Chemistry with specialization in Physical Chemistry
    Identifiers
    urn:nbn:se:uu:diva-335979 (URN)10.1039/c6se00066e (DOI)000422769100006 ()
    Available from: 2017-12-11 Created: 2017-12-11 Last updated: 2018-12-17Bibliographically approved
    3. Magnetic Manipulation of Spontaneous Emission from Inorganic CsPbBr3 Perovskites Nanocrystals
    Open this publication in new window or tab >>Magnetic Manipulation of Spontaneous Emission from Inorganic CsPbBr3 Perovskites Nanocrystals
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    2016 (English)In: ADVANCED OPTICAL MATERIALS, ISSN 2195-1071, Vol. 4, no 12, p. 2004-2008Article in journal (Refereed) Published
    Abstract [en]

    Metal halide perovskites have shown great potential for both light-absorbing and light-emitting devices. It is demonstrated that the presence of a low-magnetic field decreases dramatically the photoluminescence of CsPbBr3. This is found to be due to a decrease in charge separated state lifetime. The effect is fully reversible, and can be exploited for simple and remote modulation of the output of light-emitting devices.

    National Category
    Physical Chemistry Materials Chemistry
    Identifiers
    urn:nbn:se:uu:diva-315916 (URN)10.1002/adom.201600611 (DOI)000392405100014 ()
    Funder
    Knut and Alice Wallenberg FoundationSwedish Research Council, 2015-03764EU, FP7, Seventh Framework Programme, 306733
    Available from: 2017-02-23 Created: 2017-02-23 Last updated: 2018-12-17Bibliographically approved
    4. Hydrogen evolution with CsPbBr3 perovskite nanocrystals under visible light in solution
    Open this publication in new window or tab >>Hydrogen evolution with CsPbBr3 perovskite nanocrystals under visible light in solution
    2018 (English)In: MATERIALS TODAY COMMUNICATIONS, ISSN 2352-4928, Vol. 16, p. 90-96Article in journal (Refereed) Published
    Abstract [en]

    Direct proton photo-reduction to molecular hydrogen with a lead-halide perovskite photosystem is presented. The concept uses CsPbBr3 nanocrystals and Ru@TiO2 nanoparticles as light harvesters and catalyst, respectively. The photo-system attains charge transfer from donor to acceptor via collision events, established via static and ultrafast spectroscopy. The photo-system exhibits a photon-to-hydrogen efficiency of ca. 0.4%, a respectable efficiency for a system relying on effective collisions for the transference of electrons.

    Keywords
    Inorganic perovskites nanocrystals, H-2 evolution, Ultrafast spectroscopy, Charge transfer via collision
    National Category
    Materials Chemistry Physical Chemistry Condensed Matter Physics
    Identifiers
    urn:nbn:se:uu:diva-364171 (URN)10.1016/j.mtcomm.2018.05.001 (DOI)000443035000012 ()
    Funder
    Swedish Research CouncilStiftelsen Olle Engkvist Byggmästare
    Available from: 2018-11-06 Created: 2018-11-06 Last updated: 2018-12-17Bibliographically approved
    5. Nano-hybrid plasmonic photocatalyst for hydrogen production at 20% efficiency
    Open this publication in new window or tab >>Nano-hybrid plasmonic photocatalyst for hydrogen production at 20% efficiency
    Show others...
    2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 8670Article in journal (Refereed) Published
    Abstract [en]

    The efficient conversion of light energy into chemical energy is key for sustainable human development. Several photocatalytic systems based on photovoltaic electrolysis have been used to produce hydrogen via water reduction. However, in such devices, light harvesting and proton reduction are carried separately, showing quantum efficiency of about 10–12%. Here, we report a nano-hybrid photocatalytic assembly that enables concomitant reductive hydrogen production and pollutant oxidation with solar-to-fuel efficiencies up to 20%. The modular architecture of this plasmonic material allows the fine-tuning of its photocatalytic properties by simple manipulation of a reduced number of basic components.

    National Category
    Nano Technology
    Research subject
    Engineering Science with specialization in Nanotechnology and Functional Materials; Engineering Science with specialization in Nanotechnology and Functional Materials
    Identifiers
    urn:nbn:se:uu:diva-328630 (URN)10.1038/s41598-017-09261-7 (DOI)000407864400051 ()
    Funder
    The Swedish Foundation for International Cooperation in Research and Higher Education (STINT), IB2015-6474
    Available from: 2017-08-28 Created: 2017-08-28 Last updated: 2018-12-17Bibliographically approved
    6. Hydrated Electron Generation by Excitation of Localized Surface Plasmons in Copper Nanoparticles
    Open this publication in new window or tab >>Hydrated Electron Generation by Excitation of Localized Surface Plasmons in Copper Nanoparticles
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    (English)In: Science Advances, E-ISSN 2375-2548Article in journal (Refereed) Submitted
    National Category
    Physical Chemistry
    Identifiers
    urn:nbn:se:uu:diva-369929 (URN)
    Available from: 2018-12-17 Created: 2018-12-17 Last updated: 2019-03-20
  • 3.
    Gupta, Deepesh Kumar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University.
    Adhesion-dependent mechanisms regulating mitosis2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Integrin-mediated cell adhesion is required for normal cell cycle progression during G1-S transition and for the completion of cytokinesis. Cancer cells have ability to grow anchorage-independently, but the underlying mechanisms and the functional significance for cancer development are unclear. The current thesis describes new data on the adhesion-linked molecular mechanisms regulating cytokinesis and centrosomes. 

          Non-adherent fibroblast failed in the last step of the cytokinesis process, the abscission. This was due to lack of CEP55-binding of ESCRT-III and its associated proteins to the midbody (MB) in the intercellular bridge (ICB), which in turn correlated with too early disappearance of PLK1 and the consequent premature CEP55 accumulation. Integrin-induced FAK activity was found to be an important upstream step in the regulation of PLK1 and cytokinetic abscission. Under prolonged suspension culture, the MB disappeared but septin filaments kept the ICB in the ingressed state. Upon re-plating on fibronectin, such cells were found to divide through traction-based abscission. Non-adherent cytokinetic cells maintained septin filaments around the ICB for >24 hours, but septin was gradually depolymerized later on and furrow-regressed binucleated cells were generated (<15%). Binucleated non-transformed cells were halted in G1 and became senescent, possibly via PIDDosome formation by two centrosomes merging. In contrast to normal fibroblasts, ras-transformed fibroblasts were able to recruit the ESCRT-III-associated protein ALIX to MB under non-adherent condition. Live-cell imaging and septin-7 immuno-staining showed that cytokinetic abscission occurred in non-adherent ras-transformed fibroblast.  

          Non-adherent fibroblasts, as well as adherent cells lacking FAK expression, were also delayed in early stages of mitosis progression and exhibited defect centrosome separation and abnormal spindle formation. Our data show that integrin-dependent FAK activity promotes centrosome separation via a FAK-PLK1-Eg5 route during early mitosis.

    List of papers
    1. Integrin signaling via FAK-Src controls cytokinetic abscission by decelerating PLK1 degradation and subsequent recruitment of CEP55 at the midbody
    Open this publication in new window or tab >>Integrin signaling via FAK-Src controls cytokinetic abscission by decelerating PLK1 degradation and subsequent recruitment of CEP55 at the midbody
    Show others...
    2016 (English)In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 7, no 21, p. 30820-30830Article in journal (Refereed) Published
    Abstract [en]

    Adhesion to extracellular matrix is required for cell cycle progression through the G1 phase and for the completion of cytokinesis in normal adherent cells. Cancer cells acquire the ability to proliferate anchorage-independently, a characteristic feature of malignantly transformed cells. However, the molecular mechanisms underlying this escape of the normal control mechanisms remain unclear. The current study aimed to identify adhesion-induced reactions regulating the cytokinesis of non-transformed human fibroblasts. The adhesion-dependent control of cytokinesis was found to occur at a late stage close to the abscission, during which the endosomal sorting complex required for transport (ESCRT) severs the thin intercellular bridge connecting two nascent daughter cells. CEP55, a key protein involved in the abscission process, was localized at the midbody in both adherent and non-adherent fibroblasts, but it was unable to efficiently recruit ALIX, TSG101, and consequently the ESCRT-III subunit CHMP4B was missing in the non-adherent cells. PLK1, a kinase that prevents premature recruitment of CEP55 to the midbody, disappeared from this site more rapidly in the non-adherent cells. A FAK-Src signaling pathway downstream of integrin-mediated cell adhesion was found to decelerate both PLK1 degradation and CEP55 accumulation at the midbody. These data identify the regulation of PLK1 and CEP55 as steps where integrins exert control over the cytokinetic abscission.

    Keywords
    cytokinesis, CEP55, PLK1, integrin, FAK
    National Category
    Cancer and Oncology
    Identifiers
    urn:nbn:se:uu:diva-299793 (URN)10.18632/oncotarget.9003 (DOI)000377746600074 ()
    Funder
    Swedish Cancer Society
    Available from: 2016-07-28 Created: 2016-07-27 Last updated: 2018-12-04Bibliographically approved
    2. Tension-induced cytokinetic abscission in human fibroblasts
    Open this publication in new window or tab >>Tension-induced cytokinetic abscission in human fibroblasts