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  • 1.
    Abdelmoniem, Amr M.
    et al.
    Cairo Univ, Dept Chem, Fac Sci, Giza, Egypt.
    Elnagdi, Mohamed H.
    Cairo Univ, Giza, Egypt;Kuwait Univ, Safat, Kuwait.
    Elsehemy, Mohamed S.
    Cairo Univ, Dept Chem, Fac Pharm, Giza, Egypt.
    El-Seedi, Hesham R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi. Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt.
    Abdelhamid, Ismail A.
    Cairo Univ, Dept Chem, Fac Sci, Giza, Egypt.
    Synthesis, Chemistry and Utilities of Diaminoazoles with Special Reference to 3,5-Diaminopyrazoles2018In: Current Organic Synthesis, ISSN 1570-1794, E-ISSN 1875-6271, Vol. 15, no 4, p. 487-514Article, review/survey (Refereed)
    Abstract [en]

    Background: Although the chemistry of heteroaromatic monoamino azoles has been surveyed more than once in the last decade, the chemistry of the di- and triaminoazoles has not been reviewed. In this article we will survey the synthesis, chemistry and utility of the diaminoazoles. In this review, the chemistry of the diaminoazoles as well as their most important utilities will be surveyed. Objective: The review focuses on recent progress in diaminoazoles (i.e. diaminopyrazoles, diaminoimidazoles, diaminotriazoles and diaminothiazole) with especial references to diaminopyrazoles. The synthesis as well as pharmaceutical utilities are reported. There are several methods for synthesis of diaminopyrazoles. 3,5-Diaminopyrazole and its derivatives are prepared through the reaction of malononitrile or arylhydrazononitrile with hydrazine derivatives. 3,4-Diaminopyrazoles are prepared via nitration of 3-aminopyrazole with subsequent reduction of the produced compound. The diaminopyrazoles have several applications in cosmetic and pharmaceutical industries. They also have useful utilities as a constituent in oxidative hair dyes. Conclusion: We managed to report the common methods for the synthesis of diaminoazoles with especial reference to aminopyrazoles that are prepared through the reaction of malononitrile or hydrazononitriles with hydrazine derivatives. Some important applications that include pharmaceutical utilities such as hair dye constituents are reported.

  • 2. Andersson, Hanna
    et al.
    Carlsson, anna-Carin
    Nekoueishahraki, Bijan
    Brath, Ulrika
    Erdelyi, Mate
    Solvent effects of nitrogen chemical shifts2015In: Annual Reports on NMR Spectroscopy, ISSN 0066-4103, E-ISSN 2163-6052, Vol. 86, p. 73-210Article, review/survey (Refereed)
  • 3.
    Baltzer, Lars
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Polypeptide Conjugate Binders for Protein Recognition2007In: Topics in current chemistry, ISSN 0340-1022, E-ISSN 1436-5049, Vol. 277, p. 89-106Article, review/survey (Refereed)
    Abstract [en]

    A new class of hybrid molecules for protein recognition is presented, where polypeptides are covalently linked to small organic molecules to form polypeptide conjugates that bind proteins with high affinity and selectivity. To illustrate the concept, a binder for human carbonic anhydrase 11 with a dissociation constant of 4 nM is described. The affinity of the polypeptide conjugate arises from cooperativity in binding between a benzenesulfonamide residue, with a dissociation constant of 1.5 mu M, and the polypeptide scaffold with a dissociation constant of < 1 mM. The combination of a ligand with moderate affinity for a target protein with a polypeptide relaxes considerably the need for high affinity on the part of the polypeptide, and thus the need for structural complexity and preorganization. At the same time, the requirement for high affinity on the part of ligand is relaxed. As a consequence, the time for development of robust, high affinity, selective binder is shortened. The chemical approach to protein recognition provides well-defined molecular entities that are conveniently handled, stored and site-specifically functionalized.

  • 4.
    Baltzer, Lars
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    DeGrado, W. F.
    Engineering and design: Expanding the protein world2004In: Editorial overview Current Opinion of Structural Biology, Vol. 14, p. 455-457Article, review/survey (Other (popular scientific, debate etc.))
  • 5.
    Bellissent-Funel, Marie-Claire
    et al.
    CEA Saclay, CNRS, Lab Leon Brillouin, F-91191 Gif Sur Yvette, France..
    Hassanali, Ali
    Abdus Salaam Int Ctr Theoret Phys, Condensed Matter & Stat Phys, I-34151 Trieste, Italy..
    Havenith, Martina
    Ruhr Univ Bochum, Fac Chem & Biochem, Univ Str 150 Bldg NC 7-72, D-44780 Bochum, Germany..
    Henchman, Richard
    Univ Manchester, Manchester Inst Biotechnol, 131 Princess St, Manchester M1 7DN, Lancs, England..
    Pohl, Peter
    Johannes Kepler Univ Linz, Gruberstr 40, A-4020 Linz, Austria..
    Sterpone, Fabio
    Inst Biol Physicochim, Lab Biochim Theor, 13 Rue Pierre & Marie Curie, F-75005 Paris, France..
    van der Spoel, David
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics.
    Xu, Yao
    Ruhr Univ Bochum, Fac Chem & Biochem, Univ Str 150 Bldg NC 7-72, D-44780 Bochum, Germany..
    Garcia, Angel E.
    Los Alamos Natl Lab, Ctr Non Linear Studies, Los Alamos, NM 87545 USA..
    Water Determines the Structure and Dynamics of Proteins2016In: Chemical Reviews, ISSN 0009-2665, E-ISSN 1520-6890, Vol. 116, no 13, p. 7673-7697Article, review/survey (Refereed)
    Abstract [en]

    Water is an essential participant in the stability, structure, dynamics, and function of proteins and other biomolecules. Thermodynamically, changes in the aqueous environment affect the stability of biomolecules. Structurally, water participates chemically in the catalytic function of proteins and nucleic acids and physically in the collapse of the protein chain during folding through hydrophobic collapse and mediates binding through the hydrogen bond in complex formation. Water is a partner that slaves the dynamics of proteins, and water interaction with proteins affect their dynamics. Here we provide a review of the experimental and computational advances over the past decade in understanding the role of water in the dynamics, structure, and function of proteins. We focus on the combination of X-ray and neutron crystallography, NMR, terahertz spectroscopy, mass spectroscopy, thermodynamics, and computer simulations to reveal how water assist proteins in their function. The recent advances in computer simulations and the enhanced sensitivity of experimental tools promise major advances in the understanding of protein dynamics, and water surely will be a protagonist.

  • 6.
    Cadu, Alban
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Synthetical Organic Chemistry.
    Andersson, Pher G.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Synthetical Organic Chemistry.
    Development of iridium-catalyzed asymmetric hydrogenation: New catalysts, new substrate scope2012In: Journal of Organometallic Chemistry, ISSN 0022-328X, E-ISSN 1872-8561, Vol. 714, p. 3-11Article, review/survey (Refereed)
    Abstract [en]

    A review. The asym. hydrogenation of olefins is a tremendously powerful tool used to synthesize chiral mols. The field was pioneered using rhodium- and ruthenium- based catalysts; however, catalysts based on both of these metals suffer from limitations, such as the need for directing substituents near or even adjacent to the olefin. Iridium-based catalysts do not suffer from this flaw and can thus hydrogenate a wide variety of olefins, including some tetra substituted ones. It is also possible for iridium-based catalysts to hydrogenate hetero-π bonds such as those found in heteroarom. rings. This review summarizes the contributions made to this field by the authors in the past few years. [on SciFinder(R)]

  • 7. Carlsson, Anna-Carin C
    et al.
    Veiga, Alberte X
    Erdelyi, Mate
    Halogen bonding in solution.2015In: Topics in current chemistry, ISSN 0340-1022, E-ISSN 1436-5049, Vol. 359, p. 49-76Article, review/survey (Refereed)
    Abstract [en]

    Because of its expected applicability for modulation of molecular recognition phenomena in chemistry and biology, halogen bonding has lately attracted rapidly increasing interest. As most of these processes proceed in solution, the understanding of the influence of solvents on the interaction is of utmost importance. In addition, solution studies provide fundamental insights into the nature of halogen bonding, including, for example, the relative importance of charge transfer, dispersion, and electrostatics forces. Herein, a selection of halogen bonding literature is reviewed with the discussion focusing on the solvent effect and the electronic characteristics of halogen bonded complexes. Hence, charged and neutral systems together with two- and three-center bonds are presented in separate sub-sections. Solvent polarity is shown to have a slight stabilizing effect on neutral, two-center halogen bonds while strongly destabilizes charged, two-center complexes. It does not greatly influence the geometry of three-center halogen bonds, even though polar solvents facilitate dissociation of the counter-ion of charged three-center bonds. The charged three-center bonds are strengthened by increased environment polarity. Solvents possessing hydrogen bond donor functionalities efficiently destabilize all types of halogen bonds, primarily because of halogen vs hydrogen bond competition. A purely electrostatic model is insufficient for the description of halogen bonds in polar systems whereas it may give reasonable correlation to experimental data obtained in noninteracting, apolar solvents. Whereas dispersion plays a significant role for neutral, two-center halogen bonds, charged halogen bond complexes possess a significant charge transfer characteristic.

  • 8.
    Chinthakindi, Praveen K.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Drug Design and Discovery.
    Arvidsson, Per I.
    Univ KwaZulu Natal, Catalysis & Peptide Res Unit, Durban, South Africa;Karolinska Inst, Sci Life Lab, Drug Discovery & Dev Platform, Stockholm, Sweden;Karolinska Inst, Div Translat Med & Chem Biol, Dept Med Biochem & Biophys, Stockholm, Sweden.
    Sulfonyl Fluorides (SFs): More Than Click Reagents?2018In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, no 27-28, p. 3648-3666Article, review/survey (Refereed)
    Abstract [en]

    Sulfonyl fluoride (SF) containing substances are currently attracting enormous attention among practitioners of both chemical biology and synthetic organic chemistry. The groups of Jones and Liskamp have demonstrated the potential of sulfonyl fluorides as selective covalent inhibitors in studies related to drug discovery and chemical biology, respectively, in the last few years. The Sharpless group has extended the repertoire of click-reactions to those involving sulfonyl fluorides, that is, sulfur-fluoride exchange (SuFEx), a development that quickly triggered the interest in this functional group in the community of synthetic organic chemists. In this microreview, we aim to give an account of the synthetic chemistry surrounding sulfonyl fluoride containing substances from a historical perspective to present day developments.

  • 9. Erdelyi, Mate
    Application of the Halogen Bond in Protein Systems.2017In: Biochemistry, ISSN 0006-2960, E-ISSN 1520-4995, Vol. 56, no 22, p. 2759-2761Article, review/survey (Refereed)
  • 10. Erdelyi, Mate
    et al.
    Metrangolo, Pierangelo
    Introduction to the special issue on halogen bonding.2017In: Acta Crystallographica. Section B: Structural Science, Crystal Engineering and Materials, ISSN 2052-5192, E-ISSN 2052-5206, Vol. 73, no Pt 2, article id 135Article, review/survey (Refereed)
  • 11. Erdélyi, Máté
    Halogen bonding in solution.2012In: Chemical Society Reviews, ISSN 0306-0012, E-ISSN 1460-4744, Vol. 41, no 9, p. 3547-57Article, review/survey (Refereed)
    Abstract [en]

    Halogen bonding is the electron density donation based weak interaction of halogens with Lewis bases. Its applicability for molecular recognition processes long remained unappreciated and has so far mostly been studied in silico and in solid state. As most physiological processes and chemical reactions take place in solution, investigations in solutions are of highest relevance for its use in the pharmaceutical and material scientific toolboxes. Following a short discussion of the phenomenon of halogen bonding, this tutorial review presents an overview of the methods hitherto applied for gaining an improved understanding of its behaviour in solutions and summarizes the gained knowledge in order to indicate the scope of the techniques and to facilitate exciting future developments.

  • 12. Hakkert, Sebastiaan
    et al.
    Erdelyi, Mate
    Halogen bond symmetry: the N–X–N bond2015In: Journal of Physical Organic Chemistry, ISSN 0894-3230, E-ISSN 1099-1395, Vol. 28, p. 226-233Article, review/survey (Refereed)
  • 13.
    Kalepu, Jagadeesh
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Organic Chemistry.
    Pilarski, Lukasz T.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Organic Chemistry.
    Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations2019In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 24, no 5, article id 830Article, review/survey (Refereed)
    Abstract [en]

    Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of Weinreb amides as interesting substrates in transition metal-catalyzed C-H functionalization reactions. Herein, we review this part of the literature, including the metal catalysts, transformations explored so far and specific insights from mechanistic studies.

  • 14. Larhed, M
    et al.
    Hallberg, A
    Microwave-assisted high-speed chemistry: a new technique in drug discovery2001In: Drug Discovery Today, ISSN 1359-6446, E-ISSN 1878-5832, Vol. 6, no 8, p. 406-416Article, review/survey (Refereed)
    Abstract [en]

    In both lead identification and lead optimization processes there is an acute need for new organic small molecules. Traditional methods of organic synthesis are orders of magnitude too slow to satisfy the demand for these compounds. The fields of combinatorial and automated medicinal chemistry have been developed to meet the increasing requirement of new compounds for drug discovery; within these fields, speed is of the essence. The efficiency of microwave flash-heating chemistry in dramatically reducing reaction times (reduced from days and hours to minutes and seconds) has recently been proven in several different fields of organic chemistry. We believe that the time saved by using focused microwaves is potentially important in traditional organic synthesis but could be of even greater importance in high-speed combinatorial and medicinal chemistry.

  • 15. Larhed, M
    et al.
    Moberg, C
    Hallberg, A
    Microwave-accelerated homogeneous catalysis in organic chemistry2002In: Accounts of Chemical Research, ISSN 0001-4842, E-ISSN 1520-4898, Vol. 35, no 9, p. 717-727Article, review/survey (Refereed)
    Abstract [en]

    The efficiency of microwave flash heating in accelerating organic transformations (reaction times reduced from days and hours to minutes and seconds) has recently-been proven in several different fields of organic chemistry. This specific account mainly summarizes our own experiences in developing rapid, robust, and selective microwave-assisted transition metal-catalyzed homogeneous reactions. Applications include selective Heck couplings, cross-couplings, and asymmetric substitutions. The science of green chemistry was developed to meet the increasing demand for environmentally benign chemical processes. We believe the combination of metal catalysis and microwave heating will be of importance in the search for green laboratory-scale synthesis.

  • 16.
    Larik, Fayaz Ali
    et al.
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
    Saeed, Aamer
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
    Muqadar, Urooj
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
    El-Seedi, Hesham
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Faisal, Muhammad
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
    Channar, Pervaiz Ali
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
    Mehfooz, Haroon
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
    The role of Lawesson's reagent in the total synthesis of macrocyclic natural products2017In: Phosphorus Sulfur and Silicon and the Related Elements, ISSN 1042-6507, E-ISSN 1563-5325, Vol. 192, no 5, p. 490-502Article, review/survey (Refereed)
    Abstract [en]

    This review, including 111 references, describes the applications of Lawesson's reagent (LR) [2,4-bis(p-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-dithione] for the total synthesis of macrocyclic natural products. LR is a versatile reagent and shows excellent regioselectivity, chemoselectivity, and offers the products in high yield. The thionation of carbonyl moieties present in macrocyclic natural products, and cyclization to construct key heterocyclic fragments is described. Moreover, this review highlights the medicinal significance of the natural products. [GRAPHICS] .

  • 17.
    Marshall, Garland R
    et al.
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States..
    Ballante, Flavio
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States..
    Limiting Assumptions in the Design of Peptidomimetics2017In: Drug development research (Print), ISSN 0272-4391, E-ISSN 1098-2299, Vol. 78, no 6, p. 245-267Article, review/survey (Refereed)
    Abstract [en]

    Limiting the flexibility of organic compounds to enhance their affinity and selectivity for targeting a macromolecule involved in molecular recognition has become a well-developed paradigm in medicinal chemistry. While the role of reverse-turn motifs as peptidomimetics has received the most attention, β-sheets and helices are also important motifs for protein/protein interactions. The more complicated problem of mimicking the interacting surface of noncontiguous epitopes will not be considered in this review. This limited overview focuses on efforts to use amino acid synthons as secondary-structure mimetics as well as providing examples of peptidomimetic design focused on nonpeptide synthetic chemistry in contrast. In particular, the rationale of optimal design criteria for mimicry and the many naïve violations of those criteria made in its pursuit are emphasized.

  • 18.
    Moustafa, Moustafa Sherief
    et al.
    Univ Kuwait, Dept Chem, Fac Sci, POB 5969, Safat 13060, Kuwait.
    Al-Mousawi, Saleh Mohammed
    Univ Kuwait, Dept Chem, Fac Sci, POB 5969, Safat 13060, Kuwait.
    El-Seedi, Hesham
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi. Univ Karachi, Res Inst Chem, ICCBS, Karachi 75270, Pakistan;Menoufia Univ, Chem Dept, Fac Sci, Menoufia, Egypt.
    Elnagdi, Mohamed Hilmy
    Cairo Univ, Dept Chem, Fac Sci, POB 12613, Giza, Egypt.
    Chemistry of Heterocyclic Five and Six Membered Enamino Nitriles and Enamino Esters2018In: Mini-Reviews in medical chemistry, ISSN 1389-5575, E-ISSN 1875-5607, Vol. 18, no 12, p. 992-1007Article, review/survey (Refereed)
    Abstract [en]

    Progress in the chemistry of cyclic enamino-nitriles based on the advanced synthetic methodologies is reported. Due to the recent accomplishment, it becomes possible to reactivate these molecules toward electrophiles, nucleophiles and as electron rich dienes in 2+3 dipolar additions and in 4+2 cycloadditions reactions. Synthesizing the poly functionalized 4H-pyrans and their fused derivatives is a fascinating field with a multitude of biological implications such as antitumor, cardiotonic, hepatoprotective, antihypertensive, antibronchitis, as well antifungal activity. This work was conducted with particular emphasis on reviewing the work done on the cyclic enamines since 1990 up till now in order to highlight in more details the synthetic pathways, interactions and the biological activities, Furthermore; we referred to the recent original data of our group contributions within this field.

  • 19.
    Moustafa, Moustafa Sherief
    et al.
    Univ Kuwait, Fac Sci, Dept Chem, Safat Kuwait, Kuwait.
    Al-Mousawi, Saleh Mohammed
    Univ Kuwait, Fac Sci, Dept Chem, Safat Kuwait, Kuwait.
    El-Seedi, Hesham
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi.
    Elnagdi, Mohamed Hilmy
    Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt.
    Tales of the Unexpected in Synthesis of Polyfunctional Heteroaromatics2018In: Current Organic Synthesis, ISSN 1570-1794, E-ISSN 1875-6271, Vol. 15, no 5, p. 587-602Article, review/survey (Refereed)
    Abstract [en]

    Background: Our research group has a longstanding interest in the synthesis of novel functionalized heteroaromatic compounds, and the development of new methods for this purpose. During our ongoing investigations, we recently had an instance to check the reproducibility of some published results concerning the chemistry of arylhydrazonals, enamines and other functionally substituted carbonyl compounds. This work has led to the discovery of some new rearrangements, and the revision of the structures originally assigned to several molecules.

    Objective: This review surveys some correction of several erroneous reports that have appeared in the literature, and presents some interesting new rearrangements discovered in the course of investigating older reports.

    Results: The crystallographic studies revealed that the condensation of arylhydrazonals with active methylenenitriles yields arylazoniconates rather than pyridazenones as previously reported. Additionally, phenathylthiocyanate reacts with malononitrile to afford thiazoles rather than the previously reported condensation with the carbonyl group. In another example, the reaction of phenethylmalononitrile with hydrazine yields pyrazolopyridazenes rather than phenacylpyrazol-3,5-diamine. In yet another case, several interesting Dimrothtype rearrangements were observed when malononitrile was condensed with enaminones, contradicting earlier reports. Unexpectedly, these enaminones underwent self-trimerization to yield 1,3,5-trisubstituted benzenes under certain conditions. Enaminonitriles also undergo interesting and novel Dimroth rearrangements when reacted with cyclohexanedione or dehydroacetic acid derivatives.

    Conclusion: We have shown that the structures of several complex heterocyclic compounds that have been reported in the literature over the last 50 years were incorrectly assigned, possibly because the authors who originally reported them were using substandard or outdated analytical equipments.

  • 20.
    Mowbray, Sherry L
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Kathiravan, Muthu K
    Pandey, Abhishek A
    Odell, Luke R
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis2014In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 19, no 9, p. 13161-13176Article, review/survey (Refereed)
    Abstract [en]

    Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Globally, tuberculosis is second only to AIDS in mortality and the disease is responsible for over 1.3 million deaths each year. The impractically long treatment schedules (generally 6-9 months) and unpleasant side effects of the current drugs often lead to poor patient compliance, which in turn has resulted in the emergence of multi-, extensively- and totally-drug resistant strains. The development of new classes of anti-tuberculosis drugs and new drug targets is of global importance, since attacking the bacterium using multiple strategies provides the best means to prevent resistance. This review presents an overview of the various strategies and compounds utilized to inhibit glutamine synthetase, a promising target for the development of drugs for TB therapy.

  • 21.
    Ottosson, Henrik
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
    Eklöf, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
    Silenes: Connectors between classical alkenes and nonclassical heavy alkenes2008In: Coordination chemistry reviews, ISSN 0010-8545, E-ISSN 1873-3840, Vol. 252, no 12-14, p. 1287-1314Article, review/survey (Refereed)
    Abstract [en]

    Forty years have passed since the first publication of the experimental evidence for formation of a SiC double bonded compound, a silene. Since then, a large number of transient as well as isolable silenes have been studied, both experimentally and theoretically. Herein, we focus on the impact of the substituents on the electronic and geometric structure, reactivity, and other properties of (formally) SiC double bonded compounds. Qualitative quantum chemical models for the bonding are reviewed, and applied to rationalize experimental observations. Silenes can have planar (classical) structures similar to alkenes, or nonplanar (nonclassical) structures similar to the heavier alkene congeners, and their substituents are pivotal in determining which of these structures is adopted. Silene properties, ranging from charge distribution and NMR chemical shifts to reactivities, are strongly connected to the electronic structure of the silene, and thus to its substitution pattern.

  • 22.
    Roslin, Sara
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Odell, Luke R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Visible-Light Photocatalysis as an Enabling Tool for the Functionalization of Unactivated C(sp(3))-Substrates2017In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, Vol. 2017, no 15, p. 1993-2007Article, review/survey (Refereed)
    Abstract [en]

    Over the past decade, visible-light photocatalysis has emerged as one of the brightest and most dynamic fields in modern organic chemistry. By employing a transition-metal- or organic-dye-based photocatalyst in conjunction with a low-energy visible-light source, this synthetic manifold allows the facile generation of radical intermediates that can subsequently be directed through a wide range of transformations. Although initial studies focused largely on the functionalization of stabilized radical intermediates, over the past few years significant efforts have been directed towards the functionalization of challenging unactivated radical precursors. In this review we summarize the recent developments in the use of visible-light photocatalysis for the functionalization of unactivated C(sp(3))-substrates.

  • 23.
    Saeed, Aamer
    et al.
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan.
    Faisal, Muhammad
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan.
    Larik, Fayaz Ali
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan.
    El-Seedi, Hesham
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi.
    Channar, Pervaiz Ali
    Quaid I Azam Univ, Dept Chem, Islamabad , Pakistan.
    Shahzad, Danish
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan.
    Recent Progress in Pyridine Containing Heterocycles as High Performance Host Materials for Blue PHOLEDs2018In: Mini-Reviews in Organic Chemistry, ISSN 1570-193X, E-ISSN 1875-6298, Vol. 15, no 4, p. 261-273Article, review/survey (Refereed)
    Abstract [en]

    Phosphorescent Organic Light-Emitting Diodes (PHOLEDs) have an advantage of stability for a lifetime in comparison with the conventional Organic Light-Emitting Diodes (OLEDs). Green and red OLEDs have already achieved success, but for the last decade, blue OLEDs have observed a surge in the attention towards them from academia as well as the industry. There are incessant efforts devoted towards the improvement of external quantum efficiency from 25-30%. The host materials (or host compounds), hole transporting and electron transporting are the preeminent factors for the enhancement of External Quantum Efficiency (EQE). This review aims at highlighting the role of pyridine as an efficient Electron Transporting Material (ETM) for blue PHOLEDs. Pyridine having electron withdrawing nature can serve as valuable host compounds for electron transport material in PHOLEDs of a blue color. The presence of nitrogen atom in pyridine facilitates in lowering HOMO/LUMO energy levels compared to benzene ring and this assists in adding phenyl rings at the periphery of pyridine ring.

  • 24.
    Saeed, Aamer
    et al.
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
    Larik, Fayaz Ali
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
    Lal, Bhajan
    Sukkur Inst Business Adm, Dept Energy Syst Engn, Sukkur, Pakistan..
    Faisal, Muhammad
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
    El-Seedi, Hesham
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Channar, Pervaiz Ali
    Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
    Recent resurgence toward the oxidation of heteroatoms using dimethyldioxirane as an exquisite oxidant2017In: Synthetic Communications, ISSN 0039-7911, E-ISSN 1532-2432, Vol. 47, no 9, p. 835-852Article, review/survey (Refereed)
    Abstract [en]

    This review covers the literature from 2005 to till date. Oxidation chemistry is a dynamic field of organic synthesis as it keeps evolving with the passage of time. There is a recent surge in that area to switch over from inorganic oxidants to organic oxidants. The oxidation of heteroatom is an intriguing task for the synthetic chemists, as it requires mild oxidant with no harmful side products. Dimethyldioxirane serves as a super-effective oxidant as it shows high functional group tolerance and possess acetone as byproducts which is also eco-friendly. This review summarizes the heteroatom oxidation of sulfur, nitrogen, iodine, selenium, phosphorous, and platinum atoms using DMDO as an oxidant.

  • 25. Scrimin, P.
    et al.
    Baltzer, Lars
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Model Systems2005In: Editorial Overwiev, Current Opinion of Chemical Biology, no 9, p. 620-621Article, review/survey (Other (popular scientific, debate etc.))
  • 26.
    Shahid, Shereena
    et al.
    Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.
    Faisal, Muhammad
    Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
    Saeed, Aamer
    Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
    Ghumro, Sarfaraz Ali
    Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.
    El-Seedi, Hesham
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi.
    Rasheed, Samina
    Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
    Abbas, Nadir
    Univ Hail, Dept Chem Engn, Hail, Saudi Arabia.
    Larik, Fayaz Ali
    Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
    Channar, Pervaiz Ali
    Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
    Fattah, Tanzeela Abdul
    Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
    Ashraf, Zaman
    Allama Iqbal Open Univ, Dept Chem, Islamabad 44000, Pakistan.
    Solangi, Zulfiqar Ali
    Shah Abdul Latif Univ, Dept Chem, Khairpur, Pakistan.
    A Review on the Scope of TFDO-Mediated Oxidation in Organic Synthesis-Reactivity and Selectivity2018In: Current Organic Synthesis, ISSN 1570-1794, E-ISSN 1875-6271, Vol. 15, no 8, p. 1091-1108Article, review/survey (Refereed)
    Abstract [en]

    Dioxiranes are three-membered strained ring peroxides that are typical archetype examples of electrophilic entities. A dioxirane-based oxidant named 3-methyl(trifluoromethyl)dioxirane (TFDO) is a fluorinated analogue of the extremely valuable oxidant dimethyldioxirane (DMDO). Owing to the strained three-membered ring and presence of electron-withdrawing trifluoromethyl group, TFDO is several times more reactive than DMDO and acts as a significant chemical reagent. Moreover, TFDO exhibits high regio-, chemo- and stereo-selectivity even under unusual reaction conditions, i.e. at pH values close to neutrality and at sub-ambient temperatures. The TFDO transfers an oxygen atom to "unactivated" carbon-hydrogen bonds of alkanes as well as to the double bonds of alkenes and also helps in oxidation of compounds containing heteroatoms having a lone pair of electrons, such as sulfides and amines. TFDO-mediated oxidation is considered to be one of the main procedures in the 21st century for the synthesis of oxygen-containing organic molecules. This review throws light on the applications of TFDO in organic syntheses to provide an insight into the future research and gives a comprehensive summary of the selective functionalization of activated and non-activated organic compounds.

  • 27.
    Yeung, Andy Wai Kan
    et al.
    Univ Hong Kong, Oral & Maxillofacial Radiol, Appl Oral Sci, Fac Dent, Hong Kong, Peoples R China.
    Aggarwal, Bharat Bhushan
    Inflammat Res Ctr, San Diego, CA USA.
    Orhan, Ilkay Erdogan
    Gazi Univ, Fac Pharm, Ankara, Turkey.
    Barreca, Davide
    Univ Messina, Biochem & Appl Biochem, Messina, Italy.
    Battino, Maurizio
    Univ Vigo, Dept Analyt & Food Chem, Nutr & Food Sci Grp, CITACA,CACTI, Vigo Campus, Vigo, Spain.
    Belwal, Tarun
    GB Pant Natl Inst Himalayan Environm & Sustainabl, Ctr Biodivers Conservat & Management, Almora, Uttarakhand, India.
    Bishayee, Anupam
    Lake Erie Coll Osteopath Med, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211 USA.
    Daglia, Maria
    Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy.
    Devkota, Hari Prasad
    Kumamoto Univ, Grad Sch Pharmaceut Sci, Kumamoto, Japan.
    Echeverria, Javier
    Univ Santiago, Fac Quim & Biol, Dept Ciencias Ambiente, Santiago, Chile.
    El-Demerdashl, Amr
    Sorbonne Univ, Mol Commun & Adaptat Microorganismes, Museum Natl Hist Nat, UMR 7245,CNRS, Paris, France;Mansoura Univ, Div Organ Chem, Dept Chem, Fac Sci, Mansoura 35516, Egypt.
    Balacheva, Aneliya
    Bulgarian Acad Sci, Inst Mol Biol Roumen Tsanev, Dept Biochem Pharmacol & Drug Design, Sofia, Bulgaria.
    Georgieva, Maya
    Bulgarian Acad Sci, Inst Mol Biol Roumen Tsanev, Dept Biochem Pharmacol & Drug Design, Sofia, Bulgaria.
    Godfrey, Keith
    Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England;Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England.
    Gupta, Vijai Kumar
    Tallinn Univ Technol, ERA Chair Green Chem, Dept Chem & Biotechnol, Tallinn, Estonia.
    Horbanczuk, Jaroslaw Olav
    Polish Acad Sci, Inst Genet & Anim Breeding, PL-05552 Jastrzebiec, Magdalenka, Poland.
    Huminiecki, Lukasz
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Jozwik, Artur
    Polish Acad Sci, Inst Genet & Anim Breeding, PL-05552 Jastrzebiec, Magdalenka, Poland.
    Strzalkowska, Nina
    Polish Acad Sci, Inst Genet & Anim Breeding, PL-05552 Jastrzebiec, Magdalenka, Poland.
    Mocan, Andrei
    Iuliu Hatieganu Univ Med & Pharm, Dept Pharmaceut Bot, 23 Ghe Marinescu St, Cluj Napoca 400337, Romania.
    Mozos, Ioana
    Victor Babes Univ Med & Pharm Timisoara, Discipline Pathophysiol, Timisoara, Romania.
    Nabavi, Seyed Mohammad
    Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, POB 19395-5487, Tehran 1435916471, Iran.
    Pajpanova, Tamara
    Bulgarian Acad Sci, Inst Mol Biol Roumen Tsanev, Dept Biochem Pharmacol & Drug Design, Sofia, Bulgaria.
    Pittala, Valeria
    Univ Catania, Dept Drug Sci, Catania, Italy.
    Feder-Kubis, Joanna
    Wroclaw Univ Sci & Technol, Fac Chem, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland.
    Sampino, Silvestre
    Polish Acad Sci, Inst Genet & Anim Breeding, PL-05552 Jastrzebiec, Magdalenka, Poland.
    Silva, Ana Sanches
    Natl Inst Agr & Vet Res INIAV, Vairao, Vila Do Conde, Portugal;Univ Porto, Ctr Study Anim Sci CECA, ICETA, Oporto, Portugal.
    Sheridan, Helen
    Trinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Dublin, Ireland.
    Sureda, Antoni
    Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress NUCOX, E-07122 Palma De Mallorca, Balearic Island, Spain;Univ Balearic Isl, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, E-07122 Palma De Mallorca, Balearic Island, Spain.
    Tewari, Devesh
    Kumaun Univ, Fac Technol, Dept Pharmaceut Sci, Naini Tal, Uttarakhand, India.
    Wang, Dongdong
    Polish Acad Sci, Inst Genet & Anim Breeding, PL-05552 Jastrzebiec, Magdalenka, Poland.
    Weissig, Volkmar
    Midwestern Univ, Dept Pharmaceut Sci, Glendale, AZ USA.
    Yang, Yang
    Polish Acad Sci, Inst Genet & Anim Breeding, PL-05552 Jastrzebiec, Magdalenka, Poland.
    Zengin, Goekhan
    Selcuk Univ, Dept Biol, Konya, Turkey.
    Shanker, Karuna
    CSIR Cent Inst Med & Aromat Plants, Dept Analyt Chem, Lucknow 226015, Uttar Pradesh, India.
    Moosavi, Mohammad Amin
    Natl Inst Genet Engn & Biotechnol, Dept Mol Med, POB 14965-161, Tehran, Iran.
    Shah, Muhammad Ajmal
    Govt Coll Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Faisalabad 38000, Pakistan.
    Kozuharova, Ekaterina
    Med Univ Sofia, Dept Pharmacognosy, Fac Pharm, Sofia, Bulgaria.
    Al-Rimawi, Fuad
    Al Quds Univ, Fac Sci & Technol, Dept Chem & Chem Technol, Jerusalem, Palestine.
    Durazzo, Alessandra
    CREA Res Ctr Food & Nutr, ViaArdeatina 546, I-00178 Rome, Italy.
    Lucarini, Massimo
    CREA Res Ctr Food & Nutr, ViaArdeatina 546, I-00178 Rome, Italy.
    Souto, Eliana B.
    Univ Coimbra FFUC, Dept Pharmaceut Technol, Fac Pharm, Polo Ciencias Saude, P-3000548 Coimbra, Portugal;Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal.
    Santini, Antonello
    Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy.
    Malainer, Clemens
    Djilianov, Dimitar
    Agricultural Acad, Abiot Stress Grp, Agrobioinst, Sofia 1164, Bulgaria.
    Tancheva, Lyubka P.
    Bulgarian Acad Sci, Inst Neurobiol, Dept Behav Neurobiol, Sofia, Bulgaria.
    Li, Hua-Bin
    Sun Yat Sen Univ, Guangdong Engn Technol Res Ctr Nutr Translat, Guangdong Prov Key Lab Food Nutr & Hlth, Dept Nutr,Sch Publ Hlth, Guangzhou 510080, Guangdong, Peoples R China.
    Gan, Ren-You
    Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China.
    Tzvetkov, Nikolay T.
    Univ Bonn, Inst Pharmaceut, Bonn, Germany;Bulgarian Acad Sci, Inst Mol Biol Roumen Tsanev, Dept Biochem Pharmacol & Drug Design, Sofia, Bulgaria.
    Atanasov, Atanas G.
    Polish Acad Sci, Inst Genet & Anim Breeding, PL-05552 Jastrzebiec, Magdalenka, Poland;Univ Vienna, Dept Pharmacognosy, Vienna, Austria.
    Resveratrol, a popular dietary supplement for human and animal health: Quantitative research literature analysis - a review2019In: Animal Science Papers and Reports, ISSN 0860-4037, Vol. 37, no 2, p. 103-118Article, review/survey (Refereed)
    Abstract [en]

    Resveratrol is a stilbene-type bioactive molecule with a broad spectrum of reported biological effects. In this sense, the current work provides a comprehensive literature analysis on resveratrol, representing a highly-researched commercially available dietary ingredient. Bibliometric data were identified by means of the search string TOPIC=("resveratrol*") and analyzed with the VOSviewer software, which yielded 17,561 publications extracted from the Web of Science Core Collection electronic database. 'I'he ratio of original articles to reviews was 9.5:1. More than half of the overall manuscripts have been published since 2013. Major contributing countries were USA, China, Italy, South Korea, and Spain. Most of the publications appeared in journals specialized in biochemistry and molecular biology, pharmacology and pharmacy, food science technology, cell biology, or oncology. The phytochemicals or phytochemical classes that were frequently mentioned in the keywords of analyzed publications included, in descending order: resveratrol, trans-resveratrol, polyphenols, flavonoids, quercetin, stilbenes, curcumin, piceatannol, cis-resveratrol, and anthocyanins.

1 - 27 of 27
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