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  • 1.
    Liu, Xiuwen
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Pujari-Palmer, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Wenner, David
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Procter, Philip
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Insley, Gerard
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. GPBio Ltd, Unit 4D, Western Business Pk, Shannon V14 RW92, Clare, Ireland.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. Uppsala Univ, Dept Engn, Appl Mat Sci, S-75121 Uppsala, Sweden.
    Adhesive Cements That Bond Soft Tissue Ex Vivo2019In: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 12, no 15, article id 2473Article in journal (Refereed)
    Abstract [en]

    The aim of the present study was to evaluate the soft tissue bond strength of a newly developed, monomeric, biomimetic, tissue adhesive called phosphoserine modified cement (PMC). Two types of PMCs were evaluated using lap shear strength (LSS) testing, on porcine skin: a calcium metasilicate (CS1), and alpha tricalcium phosphate (alpha TCP) PMC. CS1 PCM bonded strongly to skin, reaching a peak LSS of 84, 132, and 154 KPa after curing for 0.5, 1.5, and 4 h, respectively. Cyanoacrylate and fibrin glues reached an LSS of 207 kPa and 33 kPa, respectively. alpha TCP PMCs reached a final LSS of approximate to 110 kPa. In soft tissues, stronger bond strengths were obtained with alpha TCP PMCs containing large amounts of amino acid (70-90 mol%), in contrast to prior studies in calcified tissues (30-50 mol%). When alpha TCP particle size was reduced by wet milling, and for CS1 PMCs, the strongest bonding was obtained with mole ratios of 30-50% phosphoserine. While PM-CPCs behave like stiff ceramics after setting, they bond to soft tissues, and warrant further investigation as tissue adhesives, particularly at the interface between hard and soft tissues.

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  • 2.
    Pujari-Palmer, Michael
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. 0000-0001-7004-2853.
    Guo, Hua
    Stockholm Univ, Dept Mat & Environm Chem, Stockholm, Sweden.
    Wenner, David
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Autefage, Hélène
    Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.
    Spicer, Christopher D.
    Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.
    Stevens, Molly M.
    Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden; Imperial Coll London, Dept Bioengn, Dept Mat, London, England; Imperial Coll London, Inst Biomed Engn, London, England.
    Omar, Omar
    Univ Gothenburg, Inst Clin Sci, Dept Biomat, Gothenburg, Sweden.
    Thomsen, Peter
    Univ Gothenburg, Inst Clin Sci, Dept Biomat, Gothenburg, Sweden.
    Edén, Mattias
    Stockholm Univ, Dept Mat & Environm Chem, Stockholm, Sweden.
    Insley, Gerard
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Procter, Philip
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials2018In: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 11, no 12, article id 2492Article in journal (Refereed)
    Abstract [en]

    Calcium phosphate cements (CPCs) are clinically effective void fillers that are capable of bridging calcified tissue defects and facilitating regeneration. However, CPCs are completely synthetic/inorganic, unlike the calcium phosphate that is found in calcified tissues, and they lack an architectural organization, controlled assembly mechanisms, and have moderate biomechanical strength, which limits their clinical effectiveness. Herein, we describe a new class of bioinspired CPCs that can glue tissues together and bond tissues to metallic and polymeric biomaterials. Surprisingly, alpha tricalcium phosphate cements that are modified with simple phosphorylated amino acid monomers of phosphoserine (PM-CPCs) bond tissues up to 40-fold stronger (2.5–4 MPa) than commercial cyanoacrylates (0.1 MPa), and 100-fold stronger than surgical fibrin glue (0.04 MPa), when cured in wet-field conditions. In addition to adhesion, phosphoserine creates other novel properties in bioceramics, including a nanoscale organic/inorganic composite microstructure, and templating of nanoscale amorphous calcium phosphate nucleation. PM-CPCs are made of the biocompatible precursors calcium, phosphate, and amino acid, and these represent the first amorphous nano-ceramic composites that are stable in liquids.

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