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  • 1.
    Accordini, Simone
    et al.
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Calciano, Lucia
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Marcon, Alessandro
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Pesce, Giancarlo
    INSERM, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Paris, France.
    Anto, Josep
    Inst Global Hlth, Barcelona, Spain.
    Beckmeyer-Borowko, Anna
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
    Corsico, Angelo
    Univ Pavia, IRCCS San Matteo Hosp Fdn, Div Resp Dis, Pavia, Italy.
    Imboden, Medea
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Keidel, Dirk
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
    Locatelli, Francesca
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Svanes, Cecilie
    Univ Bergen, Ctr Int Hlth, Bergen, Norway.
    Jarvis, Deborah
    Imperial Coll, Natl Heart & Lung Inst, Fac Med, London, England.
    Probst-Hensch, Nicole
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
    Minelli, Cosetta
    Imperial Coll, Natl Heart & Lung Inst, Fac Med, London, England.
    Incidence of airflow obstruction over 20 years in Europe2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 2.
    Accordini, Simone
    et al.
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Cazzoletti, Lucia
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Anto, Josep
    Inst Global Hlth, Barcelona, Spain.
    Cerveri, Isa
    Univ Pavia, IRCCS San Matteo Hosp Fdn, Div Resp Dis, Pavia, Italy.
    Corsico, Angelo
    Univ Pavia, IRCCS San Matteo Hosp Fdn, Div Resp Dis, Pavia, Italy.
    Garcia-Aymerich, Judith
    Inst Global Hlth, Barcelona, Spain.
    Heinrich, Joachim
    Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Inner City Clin, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.
    Gislason, David
    Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland.
    Jogi, Rain
    Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
    Johannessen, Ane
    Univ Bergen, Ctr Int Hlth, Bergen, Norway.
    Leynaert, Benedicte
    INSERM, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Paris, France.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Pin, Isabelle
    CHU Grenoble Alpes, Pediat, Grenoble, France.
    Portas, Laura
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Weyler, Joost
    Univ Antwerp, Epidemiol & Social Med, Antwerp, France;Univ Antwerp, StatUA Stat Ctr, Antwerp, France.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Marcon, Alessandro
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Jarvis, Deborah
    Imperial Coll, Natl Heart & Lung Inst, Fac Med, London, England.
    Asthma control and decline in FEV1/FVC ratio over 10 years in adults2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 3.
    Ahmadi, Zainab
    et al.
    Univ Lund Hosp, Div Resp Med & Allergol, Dept Clin Sci, SE-22100 Lund, Sweden..
    Lundstrom, Staffan
    Stockholms Sjukhem Fdn, Palliat Care Serv, Stockholm, Sweden.;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden..
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. Uppsala Univ, Dept Med Sci Resp Med & Allergol, Uppsala, Sweden..
    Strang, Peter
    Stockholms Sjukhem Fdn, Palliat Care Serv, Stockholm, Sweden.;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden..
    Emtner, Margareta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysioterapi.
    Currow, David C.
    Flinders Univ S Australia, Discipline Serv, Adelaide, SA 5001, Australia.;Flinders Univ S Australia, Palliat Serv, Adelaide, SA 5001, Australia.;Flinders Univ S Australia, Support Serv, Adelaide, SA 5001, Australia..
    Ekström, Magnus
    Univ Lund Hosp, Div Resp Med & Allergol, Dept Clin Sci, SE-22100 Lund, Sweden.;Flinders Univ S Australia, Discipline Serv, Adelaide, SA 5001, Australia.;Flinders Univ S Australia, Palliat Serv, Adelaide, SA 5001, Australia.;Flinders Univ S Australia, Support Serv, Adelaide, SA 5001, Australia..
    End-of-life care in oxygen-dependent COPD and cancer: a national population-based study2015Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 46, nr 4, s. 1190-1193Artikkel i tidsskrift (Fagfellevurdert)
  • 4. Albrecht, Eva
    et al.
    Sillanpaa, Elina
    Karrasch, Stefan
    Alves, Alexessander Couto
    Codd, Veryan
    Hovatta, Iiris
    Buxton, Jessica L.
    Nelson, Christopher P.
    Broer, Linda
    Hägg, Sara
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Mangino, Massimo
    Willemsen, Gonneke
    Surakka, Ida
    Ferreira, Manuel A. R.
    Amin, Najaf
    Oostra, Ben A.
    Backmand, Hell M.
    Peltonen, Markku
    Sarna, Seppo
    Rantanen, Taina
    Sipila, Sarianna
    Korhonen, Tellervo
    Madden, Pamela A. F.
    Gieger, Christian
    Jorres, Rudolf A.
    Heinrich, Joachim
    Behr, Juergen
    Huber, Rudolf M.
    Peters, Annette
    Strauch, Konstantin
    Wichmann, H. Erich
    Waldenberger, Melanie
    Blakemore, Alexandra I. F.
    de Geus, Eco J. C.
    Nyholt, Dale R.
    Henders, Anjali K.
    Piirila, Paeivi L.
    Rissanen, Aila
    Magnusson, Patrik K. E.
    Vinuela, Ana
    Pietilainen, Kirsi H.
    Martin, Nicholas G.
    Pedersen, Nancy L.
    Boomsma, Dorret I.
    Spector, Tim D.
    van Duijn, Cornelia M.
    Kaprio, Jaakko
    Samani, Nilesh J.
    Jarvelin, Marjo-Riitta
    Schulz, Holger
    Telomere length in circulating leukocytes is associated with lung function and disease2014Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 43, nr 4, s. 983-992Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and spirometric parameters (forced expiratory volume in is (FEV1), forced vital capacity (PVC) and FEV1/FVC) of 12 595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex and smoking status. We observed negative associations between telomere length and asthma (beta= -0.0452, p= 0.024) as well as COPD (beta= -0.0982, p=0.001), with associations being stronger and more significant when using GLI criteria than those of GOLD. In both diseases, effects were stronger in females than males. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p=1.07 x 10(-7)), FVC (p=2.07 x 10(-5)), and FEV1/FVC (p =5.27 x 10(-3)). The effect was somewhat weaker in apparently healthy subjects than in COPD or asthma patients. Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma, and that lung function may reflect biological ageing primarily due to intrinsic processes, which are likely to be aggravated in lung diseases.

  • 5.
    Amaral, Andre F. S.
    et al.
    Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England..
    Coton, Sonia
    Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England..
    Kato, Bernet
    Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England..
    Tan, Wan C.
    Univ British Columbia, Heart Lung Innovat Ctr, Vancouver, BC V5Z 1M9, Canada..
    Studnicka, Michael
    Paracelsus Med Univ, Dept Pulm Med, Salzburg, Austria..
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Gislason, Thorarinn
    Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Reykjavik, Iceland..
    Mannino, David
    Univ Kentucky, Div Pulm Crit Care & Sleep Med, Lexington, KY USA..
    Bateman, Eric D.
    Univ Cape Town, Dept Med, ZA-7925 Cape Town, South Africa..
    Buist, Sonia
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Burney, Peter G. J.
    Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England..
    Lung function defects in treated pulmonary tuberculosis patients2016Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 47, nr 1, s. 352-353Artikkel i tidsskrift (Fagfellevurdert)
  • 6.
    Amaral, Andre F. S.
    et al.
    Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England..
    Coton, Sonia
    Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England..
    Kato, Bernet
    Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England..
    Tan, Wan C.
    Univ British Columbia, Heart Lung Innovat Ctr, Vancouver, BC V5Z 1M9, Canada..
    Studnicka, Michael
    Paracelsus Med Univ, Dept Pulm Med, Salzburg, Austria..
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Gislason, Thorarinn
    Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Reykjavik, Iceland..
    Mannino, David
    Univ Kentucky, Div Pulm Crit Care & Sleep Med, Lexington, KY USA..
    Bateman, Eric D.
    Univ Cape Town, Dept Med, ZA-7925 Cape Town, South Africa..
    Buist, Sonia
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Burney, Peter G. J.
    Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England..
    Tuberculosis associates with both airflow obstruction and low lung function: BOLD results2015Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 46, nr 4, s. 1104-1112Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In small studies and cases series, a history of tuberculosis has been associated with both airflow obstruction, which is characteristic of chronic obstructive pulmonary disease, and restrictive patterns on spirometry. The objective of the present study was to assess the association between a history of tuberculosis and airflow obstruction and spirometric abnormalities in adults. The study was performed in adults, aged 40 years and above, who took part in the multicentre, cross-sectional, general population-based Burden of Obstructive Lung Disease study, and had provided acceptable post-bronchodilator spirometry measurements and information on a history of tuberculosis. The associations between a history of tuberculosis and airflow obstruction and spirometric restriction were assessed within each participating centre, and estimates combined using meta-analysis. These estimates were stratified by high- and low/middle-income countries, according to gross national income. A self-reported history of tuberculosis was associated with airflow obstruction (adjusted odds ratio 2.51, 95% CI 1.83-3.42) and spirometric restriction (adjusted odds ratio 2.13, 95% CI 1.42-3.19). A history of tuberculosis was associated with both airflow obstruction and spirometric restriction, and should be considered as a potentially important cause of obstructive disease and low lung function, particularly where tuberculosis is common.

  • 7. Artigas, Antonio
    et al.
    Noël, Julie-Lyn
    Brochard, Laurent
    Busari, Jamiu O
    Dellweg, Dominic
    Ferrer, Miguel
    Geiseler, Jens
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Hedenstiernalaboratoriet. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Nava, Stefano
    Navalesi, Paolo
    Orfanos, Stylianos
    Palange, Paolo
    Pelosi, Paolo
    Rohde, Gernot
    Schoenhofer, Bernd
    Vassilakopoulos, Theodoros
    Simonds, Anita K
    Defining a training framework for clinicians in respiratory critical care2014Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 44, nr 3, s. 572-577Artikkel i tidsskrift (Fagfellevurdert)
  • 8. Artigas, Antonio
    et al.
    Pelosi, Paolo
    Dellweg, Dominic
    Brochard, Laurent
    Ferrer, Miguel
    Geiseler, Jens
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Nava, Stefano
    Navalesi, Paolo
    Noel, Julie-Lyn
    Orfanos, Stylianos
    Palange, Paolo
    Schoenhofer, Bernd
    Vassilakopoulos, Theodoros
    Simonds, Anita
    Respiratory critical care HERMES syllabus: defining competencies for respiratory doctors2012Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 39, nr 6, s. 1294-1297Artikkel i tidsskrift (Annet vitenskapelig)
  • 9. Bakolis, I
    et al.
    Doekes, G
    Heinrich, J
    Zock, J P
    Heederik, D
    Kogevinas, M
    Guerra, S
    Norbäck, Dan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Ramasamy, A
    Nevalainen, A
    Svanes, C
    Chen, C M
    Verlato, G
    Olivieri, M
    Castro-Giner, F
    Jarvis, D
    Respiratory health and endotoxin: associations and modification by CD14/-260 genotype2012Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 39, nr 3, s. 573-581Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Exposure to endotoxin has been associated with increased respiratory symptoms and decrements in lung function in occupational settings but little is known about health effects of domestic exposure in adults. We describe the association of respiratory disease, IgE sensitisation, bronchial reactivity and lung function with mattress endotoxin levels in adults and determine whether these associations are modified by polymorphisms in CD14.Endotoxin levels in mattress dust from a population based sample of 972 adults were measured. Associations were examined using generalized linear mixed models, adjusting for individual and household confounders. Effect modification of these associations by CD14/-260 (rs2569190) was assessed.Mattress endotoxin levels varied from 0.1 to 402.6 EU·mg(-1). Although there was no overall association of lung function with endotoxin exposure, there was evidence that the association of FEV1 and FVC with endotoxin was modified by CD14/-260 genotype (p for interaction 0.005 and 0.013 respectively). There was no evidence that symptoms, IgE sensitisation or bronchial reactivity was associated with mattress endotoxin levels.In this large epidemiological study of adults there was no evidence that mattress endotoxin level was associated with respiratory symptoms or IgE sensitisation but the association of lung function with endotoxin levels may be modified by CD14-genotype.

  • 10. Bentayeb, Malek
    et al.
    Norbäck, Dan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Bednarek, Micha
    Bernard, Alfred
    Cai, Guihong
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Cerrai, Sonia
    Eleftheriou, Konstantinos Kostas
    Gratziou, Christina
    Holst, Gitte Juel
    Lavaud, Francois
    Nasilowski, Jacek
    Sestini, Piersante
    Sarno, Giuseppe
    Sigsgaard, Torben
    Wieslander, Gunilla
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Zielinski, Jan
    Viegi, Giovanni
    Annesi-Maesano, Isabella
    Indoor air quality, ventilation and respiratory health in elderly residents Living in nursing homes in Europe2015Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 45, nr 5, s. 1228-1238Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Few data exist on respiratory effects of indoor air quality and comfort parameters in the elderly. In the context of the GERIE study, we investigated for the first time the relationships of these factors to respiratory morbidity among elderly people permanently living in nursing homes in seven European countries. 600 elderly people from 50 nursing homes underwent a medical examination and completed a standardised questionnaire. Air quality and comfort parameters were objectively assessed in situ in the nursing home. Mean concentrations of air pollutants did not exceed the existing standards. Forced expiratory volume in 1 s/forced vital capacity ratio was highly significantly related to elevated levels of particles with a 50% cut-off aerodynamic diameter of <0.1 mu m (PM0.1) (adjusted OR 8.16, 95% CI 2.24-29.3) and nitrogen dioxide (aOR 3.74, 95% CI 1.06-13.1). Excess risks for usual breathlessness and cough were found with elevated PM10 (aOR 1.53 (95% CI 1.15-2.07) and aOR 1.73 (95% CI 1.17-10.3), respectively) and nitrogen dioxide (aOR 1.58 (95% CI 1.15-2.20) and aOR 1.56 (95% CI 1.03-2.41), respectively). Excess risks for wheeze in the past year were found with PM0.1 (aOR 2.82, 95% CI 1.15-7.02) and for chronic obstructive pulmonary disease and exhaled carbon monoxide with formaldehyde (aOR 3.49 (95% CI 1.17-10.3) and aOR 1.25 (95% CI 1.02-1.55), respectively). Breathlessness and cough were associated with higher carbon dioxide. Relative humidity was inversely related to wheeze in the past year and usual cough. Elderly subjects aged >= 80 years were at higher risk. Pollutant effects were more pronounced in the case of poor ventilation. Even at low levels, indoor air quality affected respiratory health in elderly people permanently living in nursing homes, with frailty increasing with age. The effects were modulated by ventilation.

  • 11.
    Brocki, Barbara Cristina
    et al.
    Aalborg Univ Hosp, Dept Occupat Therapy & Physiotherapy, Aalborg, Denmark.
    Westerdahl, Elisabeth
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi. Orebro Univ, Fac Med & Hlth, Dept Physiotherapy, Orebro, Sweden.
    Andreasen, Jane
    Aalborg Univ Hosp, Dept Occupat Therapy & Physiotherapy, Aalborg, Denmark;Aalborg Univ, Publ Hlth & Epidemiol Grp, Dept Hlth Sci & Technol, Aalborg, Denmark.
    Andreasen, Jan Jesper
    Aalborg Univ Hosp, Dept Cardiothorac Surg, Aalborg, Denmark;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.
    Can the Melbourne Scoring Scale be used to assess postoperative pulmonary complications in high-risk patients following lung resection?2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 12. Canova, Cristina
    et al.
    Heinrich, Joachim
    Maria Anto, Josep
    Leynaert, Benedicte
    Smith, Matthew
    Kuenzli, Nino
    Zock, Jan-Paul
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Cerveri, Isa
    de Marco, Roberto
    Toren, Kjell
    Gislason, Thorarinn
    Nowak, Dennis
    Pin, Isabelle
    Wjst, Matthias
    Manfreda, Jure
    Svanes, Cecilie
    Crane, Julian
    Abramson, Michael
    Burr, Michael
    Burney, Peter
    Jarvis, Deborah
    The influence of sensitisation to pollens and moulds on seasonal variations in asthma attacks2013Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 42, nr 4, s. 935-945Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    No large study has described the seasonal variation in asthma attacks in population-based asthmatics in whom sensitisation to allergen has been measured. 2637 young adults with asthma living in 15 countries reported the months in which they usually had attacks of asthma and had skin-prick tests performed. Differences in seasonal patterns by sensitisation status were assessed using generalised estimating equations. Most young adults with asthma reported periods of the year when their asthma attacks were more common (range: 47% in Sweden to 86% in Spain). Seasonal variation in asthma was not modified by sensitisation to house dust mite or cat allergens. Asthmatics sensitised to grass, birch and Alternaria allergens had different seasonal patterns to those not sensitised to each allergen, with some geographical variation. In southern Europe, those sensitised to grass allergens were more likely to report attacks occurred in spring or summer than in winter (OR March/April 2.60, 95% CI 1.70-3.97; OR May/June 4.43, 95% CI 2.34-8.39) and smaller later peaks were observed in northern Europe (OR May/June 1.25, 95% CI 0.60-2.64; OR July/August 1.66, 95% CI 0.89-3.10). Asthmatics reporting hay fever but who were not sensitised to grass showed no seasonal variations. Seasonal variations in asthma attacks in young adults are common and are different depending on sensitisation to outdoor, but not indoor, allergens.

  • 13.
    Carsin, Anne-Elie
    et al.
    Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain.
    Keidel, Dirk
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
    Fuertes, Elaine
    Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain.
    Imboden, Medea
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
    Weyler, Joost
    Dept Epidemiol & Social Med, Antwerp, Belgium.
    Nowak, Dennis
    Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.
    Heinrich, Joachim
    Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.
    Urrutia, Isabel
    Galdakao Hosp, Galdakao, Spain.
    Martinez-Moratalla, Jose
    Complejo Hosp Univ, Albacete, Spain.
    Caviezel, S.
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
    Beckmeyer-Borowko, A.
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
    Raherison, Chantal
    Bordeaux Univ, U1219, Bordeaux, France.
    Pin, Isabelle
    CHU Grenoble Alpes, Grenoble, France.
    Demoly, Pascal
    Univ Hosp Montpellier, Hop Arnaud Villeneuve, Dept Pneumol & Addictol, Montpellier, France.
    Leynaert, Benedicte
    Univ Paris Diderot, INSERM, Equipe Epidemiol, UMR 1152, Paris, France.
    Cerveri, I.
    Univ Pavia, Pavia, Italy.
    Bono, Roberto
    Univ Turin, Dept Publ Hlth & Pediat, Turin, Italy.
    Accordini, Simone
    Univ Verona, Dipartimento Diagnost & Sanita Pubbl, Verona, Italy.
    Amaral, A.
    Imperial Coll London, London, England.
    Gislason, Thorarig
    Univ Iceland, Reykjavik, Iceland.
    Svanes, Cecilie
    Univ Bergen, Dept Clin Sci, Bergen, Norway.
    Toren, K.
    Univ Gothenburg, Gothenburg, Sweden.
    Forsberg, Bertil
    Umea Univ, Div Occupat & Environm Med, Umea, Sweden.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Dharmage, S.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
    Jogi, Rain
    Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
    Anto, Jm
    Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain.
    Probst-Hensch, Nicole
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
    Garcia-Aymerich, Judith
    Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain.
    Physical activity and incidence of restrictive spirometry pattern in adults2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 14. Castro-Giner, F.
    et al.
    Kogevinas, M.
    Imboden, M.
    de Cid, R.
    Jarvis, D.
    Mächler, M.
    Berger, W.
    Burney, P.
    Franklin, K. A.
    Gonzalez, J. R.
    Heinrich, J.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Omenaas, E.
    Pin, I.
    Rochat, T.
    Sunyer, J.
    Wjst, M.
    Antó, J-M.
    Estivill, X.
    Probst-Hensch, N. M.
    Joint effect of obesity and TNFA variability on asthma: two international cohort studies2009Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 33, nr 5, s. 1003-1009Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Obesity is a risk factor for asthma. Adipose tissue expresses pro-inflammatory molecules including tumour necrosis factor (TNF), and levels of TNF are also related to polymorphisms in the TNF-alpha (TNFA) gene. The current authors examined the joint effect of obesity and TNFA variability on asthma in adults by combining two population-based studies. The European Community Respiratory Health Survey and the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults used comparable protocols, questionnaires and measures of lung function and atopy. DNA samples from 9,167 participants were genotyped for TNFA -308 and lymphotoxin-alpha (LTA) +252 gene variants. Obesity and TNFA were associated with asthma when mutually adjusting for their independent effects (odds ratio (OR) for obesity 2.4, 95% confidence interval (CI) 1.7-3.2; OR for TNFA -308 polymorphism 1.3, 95% CI 1.1-1.6). The association of obesity with asthma was stronger for subjects carrying the G/A and A/A TNFA -308 genotypes compared with the more common G/G genotype, particularly among nonatopics (OR for G/A and A/A genotypes 6.1, 95% CI 2.5-14.4; OR for G/G genotype 1.7, 95% CI 0.8-3.3). The present findings provide, for the first time, evidence for a complex pattern of interaction between obesity, a pro-inflammatory genetic factor and asthma.

  • 15. Cerveri, I
    et al.
    Corsico, A G
    Accordini, S
    Cervio, G
    Ansaldo, E
    Grosso, A
    Niniano, R
    Tsana Tegomo, E
    Antó, J M
    Künzli, N
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Sunyer, J
    Svanes, C
    Heinrich, J
    Schouten, J P
    Wjst, M
    Pozzi, E
    de Marco, R
    What defines airflow obstruction in asthma?2009Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 34, nr 3, s. 568-573Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Asthma guidelines from the Global Initiative for Asthma (GINA) and from the National Heart, Lung, and Blood Institute provide conflicting definitions of airflow obstruction, suggesting a fixed forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC) cut-off point and the lower limit of normality (LLN), respectively. The LLN was recommended by the recent American Thoracic Society/European Respiratory Society guidelines on lung function testing. The problem in using fixed cut-off points is that they are set regardless of age and sex in an attempt to simplify diagnosis at the expense of misclassification. The sensitivity and specificity of fixed FEV(1)/FVC ratios of 0.70, 0.75 and 0.80 versus the LLN were evaluated in 815 subjects (aged 20-44 yrs) with a diagnosis of asthma within the framework of the European Community Respiratory Health Survey. In males, the 0.70 ratio showed 76.5% sensitivity and 100.0% specificity, the 0.75 ratio 100.0% sensitivity and 92.4% specificity, and the 0.80 ratio 100.0% sensitivity but 58.1% specificity. In females, the 0.70 ratio showed 57.3% sensitivity and 100.0% specificity, the 0.75 ratio 91.5% sensitivity and 95.9% specificity, and the 0.80 ratio 100.0% sensitivity but 72.9% specificity. The fixed cut-off points cause a lot of misidentification of airflow obstruction in young adults, with overestimation with the 0.80 ratio and underestimation with the 0.70 ratio. In conclusion, the GINA guidelines should change their criteria for defining airflow obstruction.

  • 16. Chinn, S.
    et al.
    Downs, S. H.
    Anto, J. M.
    Gerbase, M. W.
    Leynaert, B.
    de Marco, R.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Jarvis, D.
    Künzli, N.
    Sunyer, J.
    Svanes, C.
    Zemp, E.
    Ackermann-Liebrich, U.
    Burney, P.
    Incidence of asthma and net change in symptoms in relation to changes in obesity2006Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 28, nr 4, s. 763-771Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The incidence of asthma has been reported to be associated with obesity. An alternative analysis, of net change in prevalence, does not require exclusion of those with asthma at baseline.

    Follow-up data were obtained from 9,552 participants in the European Community Respiratory Health Survey and the Swiss cohort Study on Air Pollution and Lung Disease in Adults. Incidence of asthma was analysed by proportional hazards regression, and net changes in symptoms and asthma status by generalised estimating equations, by obesity group.

    Incidence and net change in ever having had asthma were greater in females than in males, and in participants who remained obese compared with those who were never obese (hazard ratio 2.00, 95% confidence interval 1.25-3.20; excess net change 2.8%, 0.4-5.3% per 10 yrs). The effect of being obese on net change in diagnosed asthma was greater in females than in males, but for net change in wheeze without a cold it was greater in males.

    The present results are consistent with asthma being more frequently diagnosed in females, especially obese females. These findings may help to explain the reports of a stronger association between asthma and obesity in females than in males.

  • 17.
    de Marco, Roberto
    et al.
    Univ Verona, Dept Publ Hlth & Community Med, Unit Epidemiol & Med Stat, I-37134 Verona, Italy..
    Marcon, Alessandro
    Univ Verona, Dept Publ Hlth & Community Med, Unit Epidemiol & Med Stat, I-37134 Verona, Italy..
    Rossi, Andrea
    Azienda Osped Univ Integrata, Pulm Unit, Verona, Italy.;Univ Verona, I-37134 Verona, Italy..
    Anto, Josep M.
    Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.;Hosp del Mar, Med Res Inst, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBERESP, Barcelona, Spain..
    Cerveri, Isa
    Univ Pavia, San Matteo Hosp Fdn, Ist Ricovero & Cura Carattere Sci, I-27100 Pavia, Italy..
    Gislason, Thorarinn
    Landspitali Univ Hosp, Dept Resp Med & Sleep, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Heinrich, Joachim
    Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, Munich, Germany.;Univ Munich, Univ Hosp Munich, Inner City Clin, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany..
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Jarvis, Deborah
    Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol & Publ Hlth Grp, London, England..
    Kuenzli, Nino
    Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland..
    Leynaert, Benedicte
    Fac Paris Diderot, INSERM, Inserm Epidemiol U1152, Paris, France..
    Probst-Hensch, Nicole
    Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland..
    Svanes, Cecilie
    Univ Bergen, Ctr Int Hlth, Bergen Resp Res Grp, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norway..
    Wjst, Matthias
    Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Lung Biol & Dis, Comprehens Pneumol Ctr, Munich, Germany.;Tech Univ Munich, Inst Med Stat & Epidemiol, D-80290 Munich, Germany..
    Burney, Peter
    Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol & Publ Hlth Grp, London, England..
    Asthma, COPD and overlap syndrome: a longitudinal study in young European adults2015Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 46, nr 3, s. 671-679Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We compared risk factors and clinical characteristics, 9-year lung function change and hospitalisation risk across subjects with the asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS), asthma or COPD alone, or none of these diseases. Participants in the European Community Respiratory Health Survey in 1991-1993 (aged 20-44 years) and 1999-2001 were included. Chronic airflow obstruction was defined as pre-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity<lower limit of normal on both occasions. Based on their history of respiratory symptoms, spirometry and risk factors, subjects were classified as having asthma alone (n=941), COPD alone (n=166), ACOS (n=218) and none of these (n=5659). Subjects with ACOS shared risk factors and clinical characteristics with subjects with asthma alone, but they had an earlier age of asthma onset. FEV1 change in the ACOS group (-25.9 mL.year(-1)) was similar to that in the asthma group (-25.3 mL.year(-1)), and lower (p<0.001) than in the COPD group (-37.3 mL.year(-1)). ACOS was associated with the highest hospitalisation rate. Among young adults aged 20-44 years, ACOS seems to represent a form of severe asthma, characterised by more frequent hospitalisations, and to be the result of early-onset asthma that has progressed to fixed airflow obstruction.

  • 18. Dharmage, S. C.
    et al.
    Erbas, B.
    Jarvis, D.
    Wjst, M.
    Raherison, C.
    Norbäck, Dan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Heinrich, J.
    Sunyer, J.
    Svanes, C.
    Do childhood respiratory infections continue to influence adult respiratory morbidity?2009Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 33, nr 2, s. 237-244Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of the present study was to examine the influence of childhood respiratory infections on adult respiratory health. In 1992-1994, the European Community Respiratory Health Survey recruited community based samples of 20-44-yr-old people from 48 centres in 22 countries. Study participants completed questionnaires and underwent lung function testing. On average, 8.9 yrs later, 29 centres re-investigated their samples using similar methods. Mixed effects models comprising an estimate for the random variation between centres were used to evaluate the relevant associations. In total, 9,175 patients participated in both studies, of whom 10.9% reported serious respiratory infections (SRI) before 5 yrs of age and 2.8% reported hospitalisation for lung disease (HLD) before 2 yrs if age. SRI was associated with current wheeze (odds ratio (OR) 1.9, 95% confidence interval (CI) 1.7-2.2), asthma (OR 2.5, 95% CI 2.2-3.1), and lower forced expiratory volume in one second (FEV(1); 89 mL; 95% CI 54-126), forced vital capacity (FVC; 49 mL; 95% CI 8-90) and FEV(1)/FVC ratio (-1.2%; 95% CI -1.8- -0.6). Childhood respiratory infections were also associated with new asthma (OR 1.5, 95% CI 1.03-2.0), new wheeze (OR 1.5, 95% CI 1.0-2.4) and persistent wheeze (OR 2.2, 95% CI 1.4-3.6) but not with a decline in lung function. Similar findings were observed for HDL. These associations were significantly consistent across centres. SRI was associated with lower FEV(1) when excluding ever asthmatics and current wheezers. The impact of early infections was significantly larger in subjects exposed to maternal or active smoking. The impact of childhood respiratory infections on the respiratory system may not only last into adulthood but also influence development and persistence of adult respiratory morbidity.

  • 19. Eichler, I.
    et al.
    Nilsson, M.
    Rath, E.
    Enander, I.
    Venge, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Koller, D. Y.
    Human neutrophil lipocalin, a highly specific marker for acute exacerbation in cystic fibrosis1999Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 14, nr 5, s. 1145-1149Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cystic fibrosis (CF) is characterized by the production of abnormally thick secretions in the airways, chronic bacterial endobronchial infections and a chronic, predominantly neutrophilic inflammatory response. Therefore, myeloperoxidase (MPO) and lactoferrin are frequently used as inflammatory markers. Recently, a new protein in the neutrophil granules, human neutrophil lipocalin (HNL) has been discovered. The aim of the present study was to investigate HNL in sera of patients with CF and its relation to MPO and lactoferrin as well as to acute pulmonary exacerbation. Serum concentrations of HNL, MPO and lactoferrin were determined in 42 patients with CF and in 25 healthy subjects. Patients with CF were divided into groups with and without acute pulmonary exacerbation (APE) and also with and without colonization with Pseudomonas aeruginosa (Pa). Median serum levels of HNL (200.5 microg x L(-1)), MPO (595 microg x L(-1)) and lactoferrin (1,356.5 microg x L(-1)) were significantly increased in patients with CF compared to control subjects (57.7, 178 and 478 microg x L(-1), respectively; p<0.0001). CF patients with APE had significantly increased serum concentrations of HNL (321 versus 97.7 microg x L(-1); p<0.0001), MPO (1,125 versus 300 microg x L(-1); p<0.005) and lactoferrin (4,936 versus 980 microg x L(-1); p<0.001) compared with patients in stable clinical condition. Similarly, patients colonized with Pa had significantly higher concentrations of HNL, MPO and lactoferrin than Pa negative patients. These results indicate that in patients with cystic fibrosis, serum concentrations of human neutrophil lipocalin are markedly increased with a strong relationship to myeloperoxidase and lactoferrin. Thus, determination of serum human neutrophil lipocalin concentrations may be another useful diagnostic tool to monitor neutrophil inflammation in cystic fibrosis. The more marked difference in human neutrophil lipocalin compared with myeloperoxidase concentrations with no overlap between patients with acute pulmonary exacerbation and those in stable condition even suggests that human neutrophil lipocalin may be a more sensitive and specific discriminator.

  • 20. Ekström, Magnus
    et al.
    Schiöler, Linus
    Grønseth, Rune
    Johannessen, Ane
    Svanes, Cecilie
    Leynaert, Benedicte
    Jarvis, Deborah
    Gislason, Thorarinn
    Demoly, Pascal
    Probst-Hensch, Nicole
    Pin, Isabelle
    Corsico, Angelo G
    Forsberg, Bertil
    Heinrich, Joachim
    Nowak, Dennis
    Raherison-Semjen, Chantal
    Dharmage, Shyamali C
    Trucco, Giulia
    Urrutia, Isabel
    Martinez-Moratalla Rovira, Jesús
    Sánchez-Ramos, José Luis
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Torén, Kjell
    Absolute values of lung function explain the sex difference in breathlessness in the general population2017Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 49, nr 5, artikkel-id 1602047Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    and in healthy never-smokers.The markedly more severe activity-related breathlessness among females in the general population is explained by their smaller spirometric lung volumes.

  • 21.
    Ellingsen, Jens
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Bröms, Kriistina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Gävleborg.
    Lisspers, Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Ställberg, Björn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Högman, Marieann
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Longitudinal measurements of blood eosinophils in relation to COPD outcomes2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 22. Ellison-Loschmann, L.
    et al.
    Sunyer, J.
    Plana, E.
    Pearce, N.
    Zock, J-P
    Jarvis, D.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Antó, J. M.
    Kogevinas, M.
    Socioeconomic status, asthma and chronic bronchitis in a large community-based study2007Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 29, nr 5, s. 897-905Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The present study investigated the relationship between socioeconomic status, using measures of occupational class and education level, and the prevalence and incidence of asthma (with and without atopy) and chronic bronchitis using data from the European Community Respiratory Health Survey (ECRHS). Asthma and chronic bronchitis were studied prospectively within the ECRHS (n=9,023). Incidence analyses comprised subjects with no history of asthma or bronchitis at baseline. Asthma symptoms were also assessed as a continuous score. Bronchitis risk was associated with low educational level (prevalence odds ratio (POR) 1.9; 95% confidence interval (CI) 1.4-2.8) and occupatsional class (1.8; 1.2-2.7). Incident bronchitis also increased with low educational level (risk ratio (RR) 2.8; 95%CI 1.5-5.4). Prevalent and incident asthma with no atopy were associated with low educational level. Subjects in the low occupational class (incident risk ratio (IRR) 1.4; 95%CI 1.2-1.7) and education group (IRR 1.3; 95% CI 1.1-1.6) had higher mean asthma scores than those in higher socioeconomic groups. Lower educational level was associated with increased risk of prevalent and incident chronic bronchitis and asthma with no atopy. Lower socioeconomic groups tended to have a higher prevalence and incidence of asthma, particularly higher mean asthma scores. Adjustment for variables associated with asthma and bronchitis explained little of the observed health differences by socioeconomic status.

  • 23. Emilsson, Ossur I.
    et al.
    Bengtsson, Anna
    Franklin, Karl A.
    Toren, Kjell
    Benediktsdottir, Bryndis
    Farkhooy, Amir
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Weyler, Joost
    Dom, Sandra
    De Backer, Wilfried
    Gislason, Thorarinn
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Nocturnal gastro-oesophageal reflux, asthma and symptoms of OSA: a longitudinal, general population study2013Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 41, nr 6, s. 1347-1354Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Nocturnal gastro-oesophageal reflux (nGOR) is associated with asthma and obstructive sleep apnoea (OSA). Our aim was to investigate whether nGOR is a risk factor for onset of asthma and onset of respiratory and OSA symptoms in a prospective population-based study. We invited 2640 subjects from Iceland, Sweden and Belgium for two evaluations over a 9-year interval. They participated in structured interviews, answered questionnaires, and underwent spirometries and methacholine challenge testing. nGOR was defined by reported symptoms. Subjects with persistent nGOR (n=123) had an independent increased risk of new asthma at follow-up (OR 2.3, 95% CI 1.1-4.9). Persistent nGOR was independently related to onset of respiratory symptoms (OR 3.0, 95% CI 1.6-5.6). The risk of developing symptoms of OSA was increased in subjects with new and persistent nGOR (OR 2.2, 95% CI 1.3-1.6, and OR 2.0, 95% CI 1.0-3.7, respectively). No significant association was found between nGOR and lung function or bronchial responsiveness. Persistent symptoms of nGOR contribute to the development of asthma and respiratory symptoms. New onset of OSA symptoms is higher among subjects with symptoms of nGOR. These findings provide evidence that nGOR may play a role in the genesis of respiratory symptoms and diseases.

  • 24.
    Emilsson, Össur Ingi
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Hägg, Shad Amid
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Jarvis, Deborah
    Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England.
    Garcia-Aymerich, Judith
    Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain.
    Gislason, Thorarinn
    Landspitali Univ Hosp, Dept Sleep & Lung Med, Reykjavik, Iceland.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Snoring and nocturnal gastroesophageal reflux in the ECRHS III: Association to lung function and respiratory symptoms2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 25.
    Fardin, Luca
    et al.
    European Synchrotron Radiat Facil, Grenoble, France.
    Broche, Ludovic
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Hedenstiernalaboratoriet.
    Lovric, Goran
    Swiss Light Source Paul Scherrer Inst, Lausanne, Switzerland;Ecole Polytech Fed Lausanne, CIBM, Lausanne, Switzerland.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Bravin, Alberto
    European Synchrotron Radiat Facil, Grenoble, France.
    Bayat, Sam
    European Synchrotron Radiat Facil, Grenoble, France.
    Mapping cardiac-induced lung motion using high-resolution time-resolved phase-contrast synchrotron computed tomography2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 26.
    Ferrara, Giovanni
    et al.
    Karolinska Univ Hosp, Stockholm, Sweden.
    Bartley, Karen
    Genentech Inc, San Francisco, CA 94080 USA.
    Levine, Aaron
    IQVIA, Solna, Sweden.
    Arnheim-Dahlstrom, Lisen
    IQVIA, Solna, Sweden.
    Kirchgaessler, Klaus-Uwe
    F Hoffmann La Roche Ltd, Basel, Switzerland.
    Linder, Ragnar
    IQVIA, Solna, Sweden.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Sköld, C. Magnus
    Karolinska Inst, Stockholm, Sweden.
    Pirfenidone use in a Swedish cohort of patients with pulmonary fibrosis (PF)2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 27. Franklin, Karl A.
    et al.
    Sahlin, Carin
    Stenlund, Hans
    Lindberg, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Sleep apnoea is a common occurrence in females2013Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 41, nr 3, s. 610-615Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Obstructive sleep apnoea (OSA) is primarily regarded as a male disorder, presenting with snoring, daytime sleepiness and cardiovascular disease. We aimed to determine the frequency of sleep apnoea among females in the general population. We investigated 400 females from a population-based random sample of 10,000 females aged 20-70 yrs. They answered a questionnaire and performed overnight polysomnography. OSA (apnoea/hypopnoea index (AHI) >= 5) was found in 50% (95% CI 45-55%) of females aged 20-70 yrs. Sleep apnoea was related to age, obesity and hypertension, but not to daytime sleepiness. Severe sleep apnoea (AHI >= 30) was present in 14% (95% CI 8.1-21%) of females aged 55-70 yrs and in 31% (95% CI 12-50%) of obese females with a body mass index of >= 30 kg.m(-2) aged 55-70 yrs. Sleep apnoea with daytime sleepiness and sleep apnoea with hypertension were observed as two different phenotypes of OSA. OSA occurs in 50% of females aged 20-70 yrs. 20% of females have moderate and 6% severe sleep apnoea. Sleep apnoea in females is related to age, obesity and hypertension, but not to daytime sleepiness. When searching for sleep apnoea in females, females with hypertension or obesity should be investigated.

  • 28.
    Fuertes, Elaine
    et al.
    ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.
    Carsin, Anne-Elie
    ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.
    Larsen, Vanessa Garcia
    Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Program Human Nutr, Baltimore, MD 21205 USA.
    Guerra, Stefano
    Univ Arizona, Tucson, AZ USA.
    Pin, Isabelle
    CHU Grenoble Alpes, Dept Pediat, Grenoble, France;INSERM, Inst Adv Biosci, Grenoble, France;Univ Grenoble Alpes, Grenoble, France.
    Leynaert, Benedicte
    INSERM, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Paris, France;Univ Paris Diderot Paris, UMR 1152, Paris, France.
    Accordini, Simone
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Martinez-Moratalla, Jesus
    Hosp Univ Albacete, Serv Salud Castilla La Mancha SESCAM, Serv Neumol Complejo, Albacete, Spain;Univ Castilla La Mancha, Fac Med Albacete, Albacete, Spain.
    Anto, Josep M.
    ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.
    Urrutia, Isabel
    Galdakao Hosp, Dept Resp, Galdakao, Spain.
    Le Gouellec, Audrey
    Univ Grenoble Alpes, CHU Grenoble Alpes, CNRS, Grenoble INP,TIMC IMAG, F-38000 Grenoble, France.
    Heinrich, Joachim
    Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, Munich, Germany;Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.
    Gislason, Thorarinn
    Landspitali Univ Hosp Reykjavik, Dept Resp Med & Sleep, Reykjavik, Iceland.
    Jogi, Rain
    Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Jarvis, Debbie
    Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England;Imperial Coll London, Natl Heart & Lung Inst, Dept Populat Hlth & Occupat Dis, London, England.
    Garcia-Aymerich, Judith
    ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.
    Mediation analysis of CRP on the association of physical activity with FEV1 and FVC: the ECRHS study.2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 29.
    Geale, Kirk
    et al.
    Quantify Res, Stockholm, Sweden.
    Darabi, Hatef
    Quantify Res, Stockholm, Sweden.
    Eklund, Oskar
    Quantify Res, Stockholm, Sweden.
    Lindh, Maria
    Quantify Res, Stockholm, Sweden.
    Wahl, Hanna Fues
    Quantify Res, Stockholm, Sweden.
    Ström, Oskar
    Quantify Res, Stockholm, Sweden.
    Cao, Hui
    Novartis Pharmaceut, E Hanover, NJ USA.
    Alvares, Luisa
    Novartis Pharma AG, Basel, Switzerland.
    Dodge, Rikke
    Novartis Pharmaceut AS, Copenhagen, Denmark.
    Loefroth, Emil
    Novartis Sverige AB, Taby, Sweden.
    Altraja, Alan
    Univ Tartu, Dept Pulm Med, Tartu, Estonia;Tartu Univ Hosp, Dept Pulmponary Med, Tartu, Estonia.
    Backer, Vibecke
    Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark.
    Backman, Helena
    Umea Univ, OLIN Unit, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, Umea, Sweden.
    Bjermer, Leif
    Lund Univ, Dept Clin Sci, Resp Med & Allergol, Lund, Sweden.
    Bossios, Apostolos
    Karolinska Inst, Dept Resp Med & Allergy, Stockholm, Sweden.
    Dahlen, Barbro
    Karolinska Univ Hosp, Div Resp Med & Allergy, Stockholm, Sweden.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Kankaanranta, Hannu
    Seinajoki Cent Hosp, Seinajoki, Finland.
    Kauppi, Paula
    Univ Helsinki, Dept Allergy Resp Dis & Allergol, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland.
    Kilpelainen, Maritta
    Univ Turku, Turku Univ Hosp, Dept Pulm Dis & Clin Allergol, Turku, Finland.
    Lehtimäki, Lauri
    Univ Tampere, Fac Med & Life Sci, Tampere, Finland.
    Sandström, Thomas
    Umea Univ, Dept Publ Hlth & Clin Med, Div Med, Umea, Sweden.
    Ulrik, Charlotte Suppli
    Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark;Hvidovre Univ Hosp, Dept Resp Med, Copenhagen, Denmark.
    Viinanen, Arja
    Univ Turku, Turku Univ Hosp, Dept Pulm Dis & Clin Allergol, Turku, Finland.
    Porsbjerg, Celeste
    Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark.
    Late Breaking Abstract - NORdic Database for aSThmA Research (NORDSTAR): Swedish and Finnish patients2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 30. Gronseth, Rune
    et al.
    Vollmer, William M.
    Hardie, Jon A.
    Olafsdottir, Inge Sif
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Lamprecht, Bernd
    Buist, A. Sonia
    Gnatiuc, Louisa
    Gulsvik, Amund
    Johannessen, Ane
    Enright, Paul
    Predictors of dyspnoea prevalence: results from the BOLD study2014Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 43, nr 6, s. 1610-1620Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Dyspnoea is a cardinal symptom for cardiorespiratory diseases. No study has assessed worldwide variation in dyspnoea prevalence or predictors of dyspnoea. We used cross-sectional data from population-based samples in 15 countries of the Burden of Obstructive Lung Disease (BOLD) study to estimate prevalence of dyspnoea in the full sample, as well as in an a priori defined low-risk group (few risk factors or dyspnoea-associated diseases). Dyspnoea was defined by the modified Medical Research Council questions. We used ordered logistic regression analysis to study the association of dyspnoea with site, sex, age, education, smoking habits, low/high body mass index, self-reported disease and spirometry results. Of the 9484 participants, 27% reported any dyspnoea. In the low-risk subsample (n = 4329), 16% reported some dyspnoea. In multivariate analyses, all covariates were correlated to dyspnoea, but only 13% of dyspnoea variation was explained. Females reported more dyspnoea than males (odds ratio similar to 2.1). When forced vital capacity fell below 60% of predicted, dyspnoea was much more likely. There was considerable geographical variation in dyspnoea, even when we adjusted for known risk factors and spirometry results. We were only able to explain 13% of dyspnoea variation.

  • 31.
    Grosso, Amelia
    et al.
    Univ Pavia, Dept Internal Med & Therapeut, IRCCS Policlin San Matteo Fdn, Div Resp Dis, Pavia, Italy.
    Cazzoletti, Lucia
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Albicini, Federica
    Univ Pavia, Dept Internal Med & Therapeut, IRCCS Policlin San Matteo Fdn, Div Resp Dis, Pavia, Italy.
    Gini, Erica
    Univ Pavia, Dept Internal Med & Therapeut, IRCCS Policlin San Matteo Fdn, Div Resp Dis, Pavia, Italy.
    Zanolin, Elisabetta
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Ronzoni, Vanessa
    Univ Pavia, Dept Internal Med & Therapeut, IRCCS Policlin San Matteo Fdn, Div Resp Dis, Pavia, Italy.
    Conio, Valentina
    Univ Pavia, Dept Internal Med & Therapeut, IRCCS Policlin San Matteo Fdn, Div Resp Dis, Pavia, Italy.
    Di Domenica, Rita
    Univ Pavia, Dept Internal Med & Therapeut, IRCCS Policlin San Matteo Fdn, Div Resp Dis, Pavia, Italy.
    Corsico, Angelo Guido
    Univ Pavia, Dept Internal Med & Therapeut, IRCCS Policlin San Matteo Fdn, Div Resp Dis, Pavia, Italy.
    Jarvis, Debbie
    Imperial Coll London, Natl Heart & Lung Inst, Dept Populat Hlth & Occupat Dis, London, England.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Cerveri, Isa
    Univ Pavia, Dept Internal Med & Therapeut, IRCCS Policlin San Matteo Fdn, Div Resp Dis, Pavia, Italy.
    Use of inhaled corticosteroids and the risk of osteoporosis: an international cohort study2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 32. Guerra, Stefano
    et al.
    Carsin, Anne-Elie
    Keidel, Dirk
    Sunyer, Jordi
    Leynaert, Bénédicte
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Jarvis, Debbie
    Stolz, Daiana
    Rothe, Thomas
    Pons, Marco
    Turk, Alexander
    Anto, Josep M
    Probst-Hensch, Nicole
    Health-related quality of life and risk factors associated with spirometric restriction2017Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 49, nr 5, artikkel-id 1602096Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The restrictive spirometric pattern is associated with a substantial morbidity and mortality burden. We sought to determine to what extent spirometric restriction is associated with impaired quality of life.

    We used data from two large population-based European cohorts: 6698 European Community Respiratory Health Survey (ECRHS) and 6069 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) adult participants. The restrictive pattern was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ≥lower limit of normal (LLN) and FVC <LLN; an obstructive pattern was defined as FEV1/FVC <LLN independent of FVC. The Physical Component Summary and Mental Component Summary of quality of life were computed using the Short Form-36 questionnaire.

    In both cohorts, the restrictive pattern was associated with heavy smoking, being underweight or obese and the coexistence of respiratory symptoms. In univariate analyses, compared with the normal group, both the restrictive and obstructive pattern had significant Physical Component Summary deficits (−2.77 and −2.08, respectively, in ECRHS; −3.25 and −2.14, respectively, in SAPALDIA; all p-values <0.001). However, in models adjusted for sex, age, education, body mass index, smoking, comorbidities and respiratory symptoms, only the restrictive pattern remained significantly associated with Physical Component Summary deficits (p=0.004 in ECRHS; p=0.001 in SAPALDIA).

    The restrictive spirometric pattern is associated with deficits in the physical component of quality of life that are partly independent of the presence of respiratory symptoms.

  • 33. Gustafsson, Å.
    et al.
    Bergström, U.
    Ågren, L.
    Österlund, Lars
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Bucht, A.
    Biodistribution of engineered hematite nanoparticles in healthy and asthmatic mice2013Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 42, nr 1Artikkel i tidsskrift (Fagfellevurdert)
  • 34. Haccuria, Amaryllis
    et al.
    Van Muylem, Alain
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Doan, Vi
    Michils, Alain
    Small airways dysfunction: the link between allergic rhinitis and allergic asthma2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 51, nr 2, artikkel-id 1701749Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Abnormal airway reactivity and overproduction of nitric oxide (NO) occurring in smallairways have been found in asthma. If the“one airway, one disease”concept is consistent, suchdysfunctions should also be detected in the peripheral airways of patients suffering from allergicrhinitis.We investigated whether peripheral airway reactivity and NO overproduction could bedocumented in distal airways in patients with allergic rhinitis. Exhaled NO fraction (FeNO)andtheslope (S) of phase III of the single-breath washout test (SBWT) of helium (He) and sulfurhexafluoride (SF6)weremeasuredin31patientswithallergicasthma,23allergicrhinitispatientsand 24 controls, before and after sputum induction. SBWT is sensitive to airway calibre changeoccurring in the lung periphery.TheFeNOdecrease was more significant in asthma and rhinitis than in controls (−55.1% and−50.0%,respectively,versus−40.8%) (p=0.007 and p=0.029, respectively). SSF6and SHeincreased in all groups.Change in SHe(ΔSHe)>ΔSSF6was observed in rhinitis (p=0.004) and asthma (p<0.001), whereasΔSSF6=ΔSHein controls (p=0.431).This study provides evidence of peripheral airway dysfunction in patients with allergic rhinitis quitesimilar to that described in asthma. Furthermore, a large proportion of the increased NO productionreported in allergic rhinitis appears to originate in the peripheral airways.

  • 35.
    Halvorsen, Thomas
    et al.
    Haukeland Hosp, Dept Pediat, N-5021 Bergen, Norway.;Univ Bergen, Dept Clin Sci, Bergen, Norway..
    Walsted, Emil Schwarz
    Royal Brompton Hosp, Dept Resp Med, London, England.;Bispebjerg Hosp, Resp Res Unit, Copenhagen, Denmark..
    Bucca, Caterina
    Univ Turin, Dept Med Sci, Turin, Italy.;Citta Salute & Sci, Resp Unit, Turin, Italy..
    Bush, Andrew
    Imperial Coll, Paediat Resp Med, London, England.;Royal Brompton Hosp, London, England..
    Cantarella, Giovanna
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Otolaryngol, Milan, Italy..
    Friedrich, Gerhard
    Med Univ Graz, ENT Hosp Graz, Dept Phoniatr Speech & Swallowing, Graz, Austria..
    Herth, Felix J. F.
    Heidelberg Univ, Dept Pneumol & Crit Care Med, Translat Lung Res Ctr Heidelberg, Thoraxklin, Heidelberg, Germany..
    Hull, James H.
    Royal Brompton Hosp, Dept Resp Med, London, England..
    Jung, Harald
    Hochgebirgsklin Davos, Davos, Switzerland..
    Maat, Robert
    Ropcke Zweers Hosp, Dept Otorhinolaryngol, Hardenberg, Netherlands..
    Nordang, Leif
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Remacle, Marc
    Louvain Univ Hosp Mt Godinne, Dept ORL Head & Neck Surg, Yvoir, Belgium..
    Rasmussen, Niels
    Rigshosp, Dept Otolaryngol Head & Neck Surg, Copenhagen, Denmark.;Univ Copenhagen, Copenhagen, Denmark..
    Wilson, Janet A.
    Newcastle Univ, Dept Otolaryngol Head & Neck Surg, Newcastle Upon Tyne, Tyne & Wear, England.;Freeman Rd Hosp, Newcastle Upon Tyne, Tyne & Wear, England..
    Heimdal, John-Helge
    Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Surg, Bergen, Norway..
    Inducible laryngeal obstruction: an official joint European Respiratory Society and European Laryngological Society statement2017Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 50, nr 3, artikkel-id 1602221Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Inducible laryngeal obstruction (ILO) describes an inappropriate, transient, reversible narrowing of the larynx in response to external triggers. ILO is an important cause of a variety of respiratory symptoms and can mimic asthma. Current understanding of ILO has been hampered by imprecise nomenclature and variable approaches to assessment and management. A task force of the European Respiratory Society (ERS) and European Laryngological Society (ELS) was thus set up to address this, and to identify research priorities. A literature search identified relevant articles published until June 2016, using all identifiable terms for ILO, although including only articles using laryngoscopy. In total, 172 out of 252 articles met the inclusion criteria, summarised in sections on diagnostic approach, aetiology, comorbidities, epidemiology and treatment. The consensus taxonomy published by ERS, ELS and the American College of Chest Physicians (ACCP) in 2015 is used throughout this statement. We highlight the high prevalence of ILO and the clinical impact for those affected. Despite recent advances, most aspects of this condition unfortunately remain incompletely understood, precluding firm guidance. Specifically, validated diagnostic and treatment algorithms are yet to be established, and no randomised control studies were identified in this search; hence we also make recommendations for future research.

  • 36. Heikkila, Katriina
    et al.
    Madsen, Ida E. H.
    Nyberg, Solja T.
    Fransson, Eleonor I.
    Ahola, Kirsi
    Alfredsson, Lars
    Bjorner, Jakob B.
    Borritz, Marianne
    Burr, Hermann
    Knutsson, Anders
    Koskenvuo, Markku
    Koskinen, Aki
    Nielsen, Martin L.
    Nordin, Maria
    Pahkin, Krista
    Pentti, Jaana
    Rugulies, Reiner
    Salo, Paula
    Shipley, Martin J.
    Suominen, Sakari B.
    Theorell, Tores
    Vaananen, Ari
    Vahtera, Jussi
    Virtanen, Marianna
    Westerholm, Peter J. M.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Batty, G. David
    Singh-Manoux, Archana
    Kivimaki, Mika
    Job strain and COPD exacerbations: an individual-participant meta-analysis2014Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 44, nr 1, s. 247-251Artikkel i tidsskrift (Fagfellevurdert)
  • 37. Henneberger, P. K.
    et al.
    Mirabelli, M. C.
    Kogevinas, M.
    Anto, J. M.
    Plana, E.
    Dahlman-Höglund, A.
    Jarvis, D. L.
    Kromhout, H.
    Lillienberg, L.
    Norbäck, Dan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Olivieri, M.
    Radon, K.
    Torén, K.
    Urrutia, I.
    Villani, S.
    Zock, J. P.
    The occupational contribution to severe exacerbation of asthma2010Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 36, nr 4, s. 743-750Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The goal of this study was to identify occupational risk factors for severe exacerbation of asthma and estimate the extent to which occupation contributes to these events. The 966 participants were working adults with current asthma who participated in the follow-up phase of the European Community Respiratory Health Survey. Severe exacerbation of asthma was defined as self-reported unplanned care for asthma in the past 12 months. Occupations held in the same period were combined with a general population job-exposure matrix to assess occupational exposures. 74 participants reported having had at least one severe exacerbation event, for a 1-yr cumulative incidence of 7.7%. From regression models that controlled for confounders, the relative risk (RR) was statistically significant for low (RR 1.7, 95% CI 1.1-2.6) and high (RR 3.6, 95% CI 2.2-5.8) biological dust exposure, high mineral dust exposure (RR 1.8, 95% CI 1.02-3.2), and high gas and fumes exposure (RR 2.5, 95% CI 1.2-5.5). The summary category of high dust, gas, or fumes exposure had RR 3.1 (95% CI 1.9-5.1). Based on this RR, the population attributable risk was 14.7% among workers with current asthma. These results suggest occupation contributes to approximately one in seven cases of severe exacerbation of asthma in a working population, and various agents play a role.

  • 38.
    Hillerdal, Gunnar
    et al.
    Lung Medicine, Karolonska Hospital, Stockholm, Sweden.
    Lee, J
    Blomkvist, A
    Rask-Andersen, Anna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Uddenfeldt, M
    Koyi, Hemin
    Rasmussen, E
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Pleural disease during treatment with bromocriptine in patients previously exposed to asbestos1997Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 10, nr 12, s. 2711-2715Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Bromocriptine, which is used in the treatment of Parkinson's disease, can cause adverse pleuropulmonary reactions. Exposure to asbestos can result in similar lesions. Fifteen patients with former exposure to asbestos, who developed pleural fibrosis after treatment with bromocriptine, were observed independently in Sweden (11 patients) and Australia (four patients). The patients complained of malaise, often associated with weight loss, dyspnoea, and a disturbing cough. Laboratory values included increased erythrocyte sedimentation rate and a low haemoglobin level. Lung function tests showed a restrictive lung function defect. Chest radiographs showed bilateral pleural fibrosis, with small amounts of fluid in some cases. Soon after bromocriptine was withdrawn, the patients improved clinically, and the laboratory values returned to normal. However, in most cases, pleural fibrosis and a restrictive lung function defect persisted to some extent. In conclusion, in patients who develop pleuropulmonary fibrosis whilst being treated with bromocriptine, former exposure to asbestos should be investigated. Conversely, when pleural changes develop in a patient on bromocriptine and with prior exposure to asbestos, the possible causative role of the drug should be discussed. Special follow-up may be indicated when bromocriptine is planned in a patient with previous asbestos exposure, and if symptoms or signs of pleural fibrosis develop, bromocriptine withdrawal should be considered.

  • 39. Holm, M.
    et al.
    Omenaas, E.
    Gíslason, T.
    Svanes, C.
    Jögi, Rain
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Norrman, E.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Torén, K.
    Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study)2007Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 30, nr 1, s. 62-65Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of the present study was to investigate the remission rate of adult asthma in a general population sample in relation to age, sex, asthma symptoms, allergic rhinitis and smoking. A follow-up of the random population samples from the European Community Respiratory Health Survey in Northern Europe was conducted from 1999-2001 on 1,153 individuals (aged 26-53 yrs) with reported asthma. Remission was defined as no asthmatic symptoms in two consecutive years and no current use of asthma medication. Remission rates per 1,000 person-yrs were calculated and Cox regression models, adjusting for confounders, were used to estimate hazard ratios (HR) with 95% confidence intervals (CI). An average remission rate of 20.2 per 1,000 person-yrs was found. There was no significant difference according to sex; the remission rates were 21.7 and 17.8 per 1,000 person-yrs in females and males, respectively. An increased remission rate was observed among subjects who quit smoking during the observation period. Subjects not reporting any asthma symptom at baseline had an increased remission rate. In the Cox regression model, ex-smoking (HR 1.65P 95% Cl 1.01-2.71) was associated with increased remission rate, and reporting any asthma symptom at baseline was associated with decreased remission rate (HR 0.7, 95% Cl 0.40-0.90). In conclusion, the present prospective longitudinal study showed that quitting smoking and the presence of mild disease appeared to favour remission.

  • 40.
    Horváth, Ildiko
    et al.
    Natl Koranyi Inst Pulmonol, Dept Pulmonol, Piheno Ut 1, Budapest, Hungary..
    Barnes, Peter J.
    Imperial Coll London, Royal Brompton Hosp, Natl Heart & Lung Inst, London, England..
    Loukides, Stelios
    Nimits Hosp, Pulm Dept, Athens, Greece..
    Sterk, Peter J.
    Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands..
    Högman, Marieann
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Olin, Anna-Carin
    Sahlgrenska Acad & Univ Hosp, Occupat & Environm Med, Gothenburg, Sweden..
    Amann, Anton
    Innsbruck Med Univ, Innsbruck, Austria..
    Antus, Balazs
    Natl Koranyi Inst Pulmonol, Dept Pathophysiol, Budapest, Hungary..
    Baraldi, Eugenio
    Univ Padua, Pediat Pneumonol, Padua, Italy..
    Bikov, Andras
    Semmelweis Univ, Dept Pulmonol, Budapest, Hungary..
    Boots, Agnes W.
    Maastricht Univ, Dept Pharmacol & Toxicol, Maastricht, Netherlands..
    Bos, Lieuwe D.
    Univ Amsterdam, Acad Med Ctr, Intens Care, Amsterdam, Netherlands..
    Brinkman, Paul
    Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands..
    Bucca, Caterina
    Univ Torino, Biomed Sci & Human Oncol, Turin, Italy..
    Carpagnano, Giovanna E.
    Univ Foggia, Dept Med & Surg Sci, Foggia, Italy..
    Corradi, Massimo
    Univ Parma, Parma, Italy..
    Cristescu, Simona
    Radboud Univ Nijmegen, Inst Mol & Mat, Dept Mol & Laser Phys, Nijmegen, Netherlands..
    de Jongste, Johan C.
    Erasmus MC Sophia Childrens Hosp, Dept Pediat Resp Med, Rotterdam, Netherlands..
    Dinh-Xuan, Anh-Tuan
    Paris Descartes Univ, Cochin Hosp, Physiol, Paris, France..
    Dompeling, Edward
    Maastricht Univ, Med Ctr, Family Med Res Sch CAPHRI, Dept Paediat, Maastricht, Netherlands..
    Fens, Niki
    Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands..
    Fowler, Stephen
    Univ Manchester Wythenshawe Hosp, Resp Res Grp, Manchester, Lancs, England..
    Hohlfeld, Jens M.
    Fraunhofer Inst Toxicol & Expt Med ITEM, Clin Airway Res, Hannover, Germany.;Medizin Hsch Hannover, Hannover, Germany..
    Holz, Olaf
    Fraunhofer Inst Toxicol & Expt Med ITEM, Clin Airway Res, Hannover, Germany..
    Jobsis, Quirijn
    Maastricht Univ, Med Ctr, Dept Paediat Resp Med, Maastricht, Netherlands..
    Van De Kant, Kim
    Maastricht Univ, Med Ctr, Family Med Res Sch CAPHRI, Dept Paediat, Maastricht, Netherlands..
    Knobel, Hugo H.
    Philips Res, High Tech Campus 11, Eindhoven, Netherlands..
    Kostikas, Konstantinos
    Univ Athens, Med Sch, Resp Med Dept 2, Athens, Greece..
    Lehtimaki, Lauri
    Univ Tampere, Med Sch, Tampere, Finland..
    Lundberg, Jon
    Karolinska Inst, Physiol & Pharmacol, Stockholm, Sweden..
    Montuschi, Paolo
    Cathol Univ Sacred Heart, Pharmacol, Rome, Italy..
    Van Muylem, Alain
    Hop Erasme Clin Univ Bruxelles, Brussels, Belgium..
    Pennazza, Giorgio
    Univ Campus Bio Med, Fac Engn, Rome, Italy..
    Reinhold, Petra
    Friedrich Loeffler Inst, Inst Mol Pathogenesis, Jena, Germany..
    Ricciardolo, Fabio L. M.
    Univ Torino, Dept Clin & Biol Sci, Clin Resp Dis, Turin, Italy..
    Rosias, Philippe
    Maastricht Univ, Med Ctr, Family Med Res Sch CAPHRI, Dept Paediat, Maastricht, Netherlands.;Maasland Hosp, Dept Pediat, Sittard, Netherlands..
    Santonico, Marco
    Univ Campus Bio Med, Fac Engn, Rome, Italy..
    van der Schee, Marc P.
    Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands..
    van Schooten, Frederik-Jan
    Maastricht Univ, Dept Pharmacol & Toxicol, Maastricht, Netherlands..
    Spanevello, Antonio
    Fdn Salvatore Maugeri, Tradate, Italy..
    Tonia, Thomy
    European Resp Soc, Lausanne, Switzerland..
    Vink, Teunis J.
    Philips Res, High Tech Campus 11, Eindhoven, Netherlands..
    A European Respiratory Society technical standard: exhaled biomarkers in lung disease2017Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 49, nr 4, artikkel-id 1600965Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.

    Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.

    Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.

    Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.

  • 41.
    Högman, Marieann
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Lisspers, Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Bröms, Kristina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Gävleborg.
    Ställberg, Björn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Determinants of FENO in COPD with regard to current smoking2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 42.
    Högman, Marieann
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Thornadtsson, Alexandra
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Gävleborg. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Bröms, Kristina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Gävleborg. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Lisspers, Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning Dalarna. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Ställberg, Björn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning Dalarna.
    Hedenström, Hans
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Higher alveolar nitric oxide in COPD is related to poorer physical capacity and lower oxygen saturation after physical testing2019Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54, nr 2, artikkel-id 1900263Artikkel i tidsskrift (Fagfellevurdert)
  • 43. Imboden, Medea
    et al.
    Wielscher, Matthias
    Rezwan, Faisal I
    Amaral, André F S
    Schaffner, Emmanuel
    Jeong, Ayoung
    Beckmeyer-Borowko, Anna
    Harris, Sarah E
    Starr, John M
    Deary, Ian J
    Flexeder, Claudia
    Waldenberger, Melanie
    Peters, Annette
    Schulz, Holger
    Chen, Su
    Sunny, Shadia Khan
    Karmaus, Wilfried J J
    Jiang, Yu
    Erhart, Gertraud
    Kronenberg, Florian
    Arathimos, Ryan
    Sharp, Gemma C
    Henderson, Alexander John
    Fu, Yu
    Piirilä, Päivi
    Pietiläinen, Kirsi H
    Ollikainen, Miina
    Johansson, Åsa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Gyllensten, Ulf B.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    de Vries, Maaike
    van der Plaat, Diana A
    de Jong, Kim
    Boezen, H Marike
    Hall, Ian P
    Tobin, Martin D
    Jarvelin, Marjo-Riitta
    Holloway, John W
    Jarvis, Deborah
    Probst-Hensch, Nicole M
    Epigenome-wide association study of lung function level and its change2019Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54, nr 1, artikkel-id 1900457Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Previous reports link differential DNA methylation (DNAme) to environmental exposures that are associated with lung function. Direct evidence on lung function DNAme is, however, limited. We undertook an agnostic epigenome-wide association study (EWAS) on pre-bronchodilation lung function and its change in adults.In a discovery-replication EWAS design, DNAme in blood and spirometry were measured twice, 6-15 years apart, in the same participants of three adult population-based discovery cohorts (n=2043). Associated DNAme markers (p<5×10-7) were tested in seven replication cohorts (adult: n=3327; childhood: n=420). Technical bias-adjusted residuals of a regression of the normalised absolute β-values on control probe-derived principle components were regressed on level and change of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and their ratio (FEV1/FVC) in the covariate-adjusted discovery EWAS. Inverse-variance-weighted meta-analyses were performed on results from discovery and replication samples in all participants and never-smokers.EWAS signals were enriched for smoking-related DNAme. We replicated 57 lung function DNAme markers in adult, but not childhood samples, all previously associated with smoking. Markers not previously associated with smoking failed replication. cg05575921 (AHRR (aryl hydrocarbon receptor repressor)) showed the statistically most significant association with cross-sectional lung function (FEV1/FVC: pdiscovery=3.96×10-21 and pcombined=7.22×10-50). A score combining 10 DNAme markers previously reported to mediate the effect of smoking on lung function was associated with lung function (FEV1/FVC: p=2.65×10-20).Our results reveal that lung function-associated methylation signals in adults are predominantly smoking related, and possibly of clinical utility in identifying poor lung function and accelerated decline. Larger studies with more repeat time-points are needed to identify lung function DNAme in never-smokers and in children.

  • 44.
    Janson, Christer
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Lisspers, Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Ställberg, Björn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Johansson, Gunnar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Thuresson, Marcus
    Statisticon AB, Uppsala, Sweden..
    Telg, Gunilla
    AstraZeneca Nord Balt, Sodertalje, Sweden..
    Larsson, Kjell
    Karolinska Inst, Natl Inst Environm Med, Stockholm, Sweden..
    Prevalence, characteristics and management of frequently exacerbating asthma patients: an observational study in Sweden (PACEHR)2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52, nr 2, artikkel-id 1701927Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of the study was to investigate the prevalence, management and characteristics of asthma patients with frequent exacerbations. Data from asthma patients (aged >= 18 years) identified in primary care medical records were linked to Swedish national health registries. Exacerbations were defined as hospitalisations, emergency visits and/or collection of oral steroids. Frequent exacerbations were defined as two or more exacerbations per year during the 3-year observation period. Of 18 724 asthma patients, 81.49% had no exacerbations and 6.3% had frequent exacerbations in the year prior to the index date. Frequent exacerbations were observed yearly for 1.8% of the patients. Frequent exacerbators were older, more often females, and had increased eosinophil and neutrophil counts, lower lung function, and more comorbidities than patients without exacerbations. There was a slight increase in asthma medication claims and a slight decrease in physician visits compared with baseline, both in the group with and the group without frequent exacerbations. Patients with frequent exacerbations were characterised by greater age, female predominance, high eosinophil and neutrophil counts, and high prevalence of comorbidities. This study indicates that the Swedish healthcare system lacks efficiency to adjust treatment and management for this patient group. With new treatment options targeting severe asthma available, identification of these patients should be in focus to ensure reduction of exacerbations.

  • 45.
    Janson, Christer
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Marks, Guy
    Buist, Sonia
    Gnatiuc, Louisa
    Gislason, Thorarinn
    McBurnie, Mary Ann
    Nielsen, Rune
    Studnicka, Michael
    Toelle, Brett
    Benediktsdottir, Bryndis
    Burney, Peter
    The impact of COPD on health status: findings from the BOLD study2013Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 42, nr 6, s. 1472-1483Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of this study was to describe the impact of chronic obstructive pulmonary disease (COPD) on health status in the Burden of Obstructive Lung Disease (BOLD) populations. We conducted a cross-sectional, general population-based survey in 11 985 subjects from 17 countries. We measured spirometric lung function and assessed health status using the Short Form 12 questionnaire. The physical and mental health component scores were calculated. Subjects with COPD (post-bronchodilator forced expiratory volume in 1 s/forced vital capacity <0.70, n=2269) had lower physical component scores (44 +/- 10 versus 48 +/- 10 units, p<0.0001) and mental health component scores (51 +/- 10 versus 52 +/- 10 units, p=0.005) than subjects without COPD. The effect of reported heart disease, hypertension and diabetes on physical health component scores (-3 to -4 units) was considerably less than the effect of COPD Global Initiative for Chronic Obstructive Lung Disease grade 3 (-8 units) or 4 (-11 units). Dyspnoea was the most important determinant of a low physical and mental health component scores. In addition, lower forced expiratory volume in 1 s, chronic cough, chronic phlegm and the presence of comorbidities were all associated with a lower physical health component score. COPD is associated with poorer health status but the effect is stronger on the physical than the mental aspects of health status. Severe COPD has a greater negative impact on health status than self-reported cardiovascular disease and diabetes.

  • 46.
    Jansson, Christer
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk cellbiologi, Integrativ Fysiologi.
    Amaral, Andre F. S.
    Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.
    Accordini, Simone
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Bousquet, Jean
    Fdn FMC VIA LR, Montpellier, France;Euforea, Brussels, Belgium;Charite Univ Med Berlin, Dept Dermatol & Allergy, Allergy Ctr Charite, Berlin, Germany.
    Buist, A. Sonia
    Oregon Hlth & Sci Univ, Pulm & Crit Care Med, Portland, OR 97201 USA.
    Canonica, Giorgio Walter
    Humanitas Res Hosp, Personalized Med Clin Asthma & Allergy, Milan, Italy.
    Dahlen, Barbro
    Karolinska Inst, Unit Heart & Lung Dis, Dept Med, Stockholm, Sweden.
    Garcia-Aymerich, Judith
    ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.
    Gnatiuc, Louisa
    Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England.
    Kowalski, Marek L.
    Med Univ Lodz, Dept Immunol & Allergy, Lodz, Poland.
    Patel, Jaymini
    Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.
    Tan, Wan
    Univ British Columbia, St Pauls Hosp Vancouver, Ctr Heart Lung Innovat, Vancouver, BC, Canada.
    Toren, Kjell
    Univ Gothenburg, Dept Occupat & Environm Med, Gothenburg, Sweden.
    Zuberbier, Torsten
    Burney, Peter
    Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.
    Jarvis, Deborah
    Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.
    Bronchodilator reversibility in asthma and COPD: findings from three large population studies2019Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54, nr 3, artikkel-id 1900561Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Bronchodilator response (BDR) testing is used as a diagnostic method in obstructive airway diseases. The aim of this investigation was to compare different methods for measuring BDR in participants with asthma and chronic obstructive pulmonary disease (COPD) and to study to the extent to which BDR was related to symptom burden and phenotypic characteristics. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured before and 15 min after 200 mu g of salbutamol in 35 628 subjects aged >= 16 years from three large international population studies. The subjects were categorised in three groups: current asthma (n=2833), COPD (n=1146) and no airway disease (n=31 649). Three definitions for flow-related reversibility (increase in FEV1) and three for volume-related reversibility (increase in FVC) were used. The prevalence of bronchodilator reversibility expressed as increase FEV1 >= 12% and 200 mL was 17.3% and 18.4% in participants with asthma and COPD, respectively, while the corresponding prevalence was 5.1% in those with no airway disease. In asthma, bronchodilator reversibility was associated with wheeze (OR 1.36, 95% CI 1.04-1.79), atopy (OR 1.36, 95% CI 1.04-1.79) and higher exhaled nitric oxide fraction, while in COPD neither flow- nor volume-related bronchodilator reversibility was associated with symptom burden, exacerbations or health status after adjusting for pre-bronchodilator FEV1. Bronchodilator reversibility was at least as common in participants with COPD as those with asthma. This indicates that measures of reversibility are of limited value for distinguishing asthma from COPD in population studies. However, in asthma, bronchodilator reversibility may be a phenotypic marker.

  • 47.
    Jansson, Christer
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning. Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Amaral, Andre F. S.
    Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.
    Accordini, Simone
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Bousquet, Jean
    Fdn FMC VIA LR, Montpellier, France;Euforea, Brussels, Belgium;Charite Univ Med Berlin, Dept Dermatol & Allergy, Allergy Ctr Charite, Berlin, Germany.
    Buist, A. Sonia
    Oregon Hlth & Sci Univ, Pulm & Crit Care Med, Portland, OR 97201 USA.
    Garcia-Aymerich, Judith
    ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBERESP, Barcelona, Spain.
    Gnatiuc, Louisa
    Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England.
    Tan, Wan
    Univ British Columbia, St Pauls Hosp Vancouver, Ctr Heart Lung Innovat Tan Sin, Vancouver, BC, Canada.
    Toren, Kjell
    Univ Gothenburg, Dept Occupat & Environm Med, Gothenburg, Sweden.
    Zuberbier, Torsten
    Charite Univ Med Berlin, Dept Dermatol & Allergy, Allergy Ctr Charite, Berlin, Germany.
    Burney, Peter
    Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.
    Testing bronchodilator responsiveness2019Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54, nr 6, artikkel-id 1902104Artikkel i tidsskrift (Annet vitenskapelig)
  • 48.
    Johannessen, Ane
    et al.
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway.
    Kuiper, Ingrid Nordeide
    Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
    Accordini, Simone
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Bertelsen, Randi Jacobsen
    Univ Bergen, Dept Clin Sci, Bergen, Norway.
    Forsberg, Bertil
    Umea Univ, Div Occupat & Environm Med, Dept Publ Hlth & Clin Med, Umea, Sweden.
    Gislason, Thorarinn
    Landspitali Univ Hosp Reykjavik, Dept Resp Med & Sleep, Reykjavik, Iceland.
    Heinrich, Joachim
    Ludwig Maximilians Univ Munchen, Inst & Clin Occupat Social & Environm Med, Munich, Germany.
    Holm, Mathias
    Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.
    Jogi, Rain
    Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
    Kirkeleit, Jorunn
    Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Marcon, Alessandro
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Markevych, Iana
    Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, Neuherberg, Germany.
    Oudin, Anna
    Umea Univ, Div Occupat & Environm Med, Dept Publ Hlth & Clin Med, Umea, Sweden.
    Schlunssen, Vivi
    Aarhus Univ, Sect Environm Occupat & Hlth, Danish Ramazzini Ctr, Dept Publ Hlth, Aarhus, Denmark.
    Sigsgaard, Torben
    Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.
    Svanes, Cecilie
    Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
    Toren, Kjell
    Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Long-term air pollution exposure is associated with sick leave 20 years later2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 49.
    Johansson, Henrik
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Emtner, Margareta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Norlander, Katarina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Nordang, Leif
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Exercise induced dyspnea among adolescents - prevalence and incidence, a five-year follow-up2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
  • 50.
    Johansson, Henrik
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysioterapi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Ersson, Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Mallmin, Elisabet
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Norlander, Katarina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Nordang, Leif
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Prevalence of exercise-induced bronchoconstriction and exercise-induced laryngeal obstruction in adolescents attending national sports high school2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikkel i tidsskrift (Annet vitenskapelig)
123 1 - 50 of 105
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