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  • 1.
    Bolund, Elisabeth
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Hayward, Adam
    Pettay, Jenni E.
    Lummaa, Virpi
    Effects of the demographic transition on the genetic variances and covariances of human life-history traits2015Inngår i: Evolution, ISSN 0014-3820, E-ISSN 1558-5646, Vol. 69, nr 3, s. 747-755Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The recent demographic transitions to lower mortality and fertility rates in most human societies have led to changes and even quick reversals in phenotypic selection pressures. This can only result in evolutionary change if the affected traits are heritable, but changes in environmental conditions may also lead to subsequent changes in the genetic variance and covariance (the G matrix) of traits. It currently remains unclear if there have been concomitant changes in the G matrix of life-history traits following the demographic transition. Using 300 years of genealogical data from Finland, we found that four key life-history traits were heritable both before and after the demographic transition. The estimated heritabilities allow a quantifiable genetic response to selection during both time periods, thus facilitating continued evolutionary change. Further, the G matrices remained largely stable but revealed a trend for an increased additive genetic variance and thus evolutionary potential of the population after the transition. Our results demonstrate the validity of predictions of evolutionary change in human populations even after the recent dramatic environmental change, and facilitate predictions of how our biology interacts with changing environments, with implications for global public health and demography.

  • 2.
    Bolund, Elisabeth
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Lummaa, V.
    Univ Turku, Dept Biol, Turku, Finland..
    The effects of resource availability and the demographic transition on the genetic correlation between number of children and grandchildren in humans2017Inngår i: Heredity, ISSN 0018-067X, E-ISSN 1365-2540, Vol. 118, nr 2, s. 186-192Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Studies of evolutionary change require an estimate of fitness, and lifetime reproductive success is widely used for this purpose. However, many species face a trade-off between the number and quality of offspring and in such cases number of grandoffspring may better represent the genetic contribution to future generations. Here, we apply quantitative genetic methods to a genealogical data set on humans from Finland to address how the genetic correlation between number of children and grandchildren is influenced by the severity of the trade-off between offspring quality and quantity, as estimated by different levels of resource access among individuals in the population. Further, we compare the genetic correlation before and after the demographic transition to low mortality and fertility rates. The genetic correlation was consistently high (0.79-0.92) with the strongest correlations occurring in individuals with higher access to resources and before the demographic transition, and a tendency for lower correlations in resource poor individuals and after the transition. These results indicate that number of grandoffspring is a slightly better predictor of long-term genetic fitness than number of offspring in a human population across a range of environmental conditions, and more generally, that patterns of resource availability need to be taken into account when estimating genetic covariances with fitness.

  • 3.
    Bolund, Elisabeth
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Lummaa, Virpi
    Univ Turku, Dept Biol, FIN-20014 Turku, Finland.;Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England..
    Smith, Ken R.
    Univ Utah, Huntsman Canc Inst, Dept Family & Consumer Studies & Populat Sci, Salt Lake City, UT 84112 USA..
    Hanson, Heidi A.
    Univ Utah, Huntsman Canc Inst, Dept Family & Prevent Med & Populat Sci, Salt Lake City, UT 84112 USA..
    Maklakov, Alexei A.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Reduced costs of reproduction in females mediate a shift from a male-biased to a female-biased lifespan in humans2016Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, artikkel-id 24672Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The causes underlying sex differences in lifespan are strongly debated. While females commonly outlive males in humans, this is generally less pronounced in societies before the demographic transition to low mortality and fertility rates. Life-history theory suggests that reduced reproduction should benefit female lifespan when females pay higher costs of reproduction than males. Using unique longitudinal demographic records on 140,600 reproducing individuals from the Utah Population Database, we demonstrate a shift from male-biased to female-biased adult lifespans in individuals born before versus during the demographic transition. Only women paid a cost of reproduction in terms of shortened post-reproductive lifespan at high parities. Therefore, as fertility decreased over time, female lifespan increased, while male lifespan remained largely stable, supporting the theory that differential costs of reproduction in the two sexes result in the shifting patterns of sex differences in lifespan across human populations. Further, our results have important implications for demographic forecasts in human populations and advance our understanding of lifespan evolution.

  • 4. Bruckner, Tim A.
    et al.
    Helle, Samuli
    Bolund, Elisabeth
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Lummaa, Virpi
    Culled males, infant mortality and reproductive success in a pre-industrial Finnish population2015Inngår i: Proceedings of the Royal Society of London. Biological Sciences, ISSN 0962-8452, E-ISSN 1471-2954, Vol. 282, nr 1799Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Theoretical and empirical literature asserts that the sex ratio (i.e. M/F) at birth gauges the strength of selection in utero and cohort quality of males that survive to birth. We report the first individual-level test in humans, using detailed life-history data, of the 'culled cohort' hypothesis that males born to low annual sex ratio cohorts show lower than expected infant mortality and greater than expected lifetime reproductive success. We applied time-series and structural equation methods to a unique multi-generational dataset of a natural fertility population in nineteenth century Finland. We find that, consistent with culled cohorts, a 1 s.d. decline in the annual cohort sex ratio precedes an 8% decrease in the risk of male infant mortality. Males born to lower cohort sex ratios also successfully raised 4% more offspring to reproductive age than did males born to higher cohort sex ratios. The offspring result, however, falls just outside conventional levels of statistical significance. In historical Finland, the cohort sex ratio gauges selection against males in utero and predicts male infant mortality. The reproductive success findings, however, provide weak support for an evolutionarily adaptive explanation of male culling in utero.

  • 5.
    Griffin, Robert M.
    et al.
    Univ Turku, Dept Biol, Turku 20014, Finland..
    Hayward, Adam D.
    Univ Stirling, Dept Biol & Environm Sci, Stirling FK9 4LA, Scotland..
    Bolund, Elisabeth
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Maklakov, Alex A
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi. Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England..
    Lummaa, Virpi
    Univ Turku, Dept Biol, Turku 20014, Finland..
    Sex differences in adult mortality rate mediated by early-life environmental conditions2018Inngår i: Ecology Letters, ISSN 1461-023X, E-ISSN 1461-0248, Vol. 21, nr 2, s. 235-242Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Variation in sex differences is affected by both genetic and environmental variation, with rapid change in sex differences being more likely due to environmental change. One case of rapid change in sex differences is human lifespan, which has become increasingly female-biased in recent centuries. Long-term consequences of variation in the early-life environment may, in part, explain such variation in sex differences, but whether the early-life environment mediates sex differences in life-history traits is poorly understood in animals. Combining longitudinal data on 60 cohorts of pre-industrial Finns with environmental data, we show that the early-life environment is associated with sex differences in adult mortality and expected lifespan. Specifically, low infant survival rates and high rye yields (an important food source) in early-life are associated with female-bias in adult lifespan. These results support the hypothesis that environmental change has the potential to affect sex differences in life-history traits in natural populations of long-lived mammals.

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