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  • 1.
    Alenius, Malin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Hammarlund-Udenaes, Margareta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Hartvig, Per
    Sundquist, Staffan
    Lindström, Leif
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Psykiatri, Akademiska sjukhuset.
    Treatmentresponse in psychotic patients classified according to social and clinical needs, drug side effects, and previous treatment; a method to identify functional remission2009Ingår i: Comprehensive Psychiatry, ISSN 0010-440X, E-ISSN 1532-8384, Vol. 50, nr 5, s. 453-462Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Various approaches have been made over the years to classify psychotic patients according to inadequate treatment response, using terms such as treatment resistant or treatment refractory. Existing classifications have been criticized for overestimating positive symptoms; underestimating residual symptoms, negative symptoms, and side effects; or being to open for individual interpretation. The aim of this study was to present and evaluate a new method of classification according to treatment response and, thus, to identify patients in functional remission. METHOD: A naturalistic, cross-sectional study was performed using patient interviews and information from patient files. The new classification method CANSEPT, which combines the Camberwell Assessment of Need rating scale, the Udvalg for Kliniske Undersøgelser side effect rating scale (SE), and the patient's previous treatment history (PT), was used to group the patients according to treatment response. CANSEPT was evaluated by comparison of expected and observed results. RESULTS: In the patient population (n = 123), the patients in functional remission, as defined by CANSEPT, had higher quality of life, fewer hospitalizations, fewer psychotic symptoms, and higher rate of workers than those with the worst treatment outcome. CONCLUSION: In the evaluation, CANSEPT showed validity in discriminating the patients of interest and was well tolerated by the patients. CANSEPT could secure inclusion of correct patients in the clinic or in research.

  • 2.
    Klötz, Fia
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Rättsmedicin.
    Petersson, Anna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Rättsmedicin.
    Hoffman, Orsolya
    Thiblin, Ingemar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Rättsmedicin.
    The significance of anabolic androgenic steroids in a Swedish prison population2010Ingår i: Comprehensive Psychiatry, ISSN 0010-440X, E-ISSN 1532-8384, Vol. 51, nr 3, s. 312-318Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Use of anabolic androgenic steroids (AAS) has been associated with adverse psychiatric effect, violent behavior, and criminality. The aim of this study was to further investigate the motives for and consequences of AAS use, with focus on violent and antisocial behavior. Fifty-nine prisoners were interviewed on their use of AAS, and their history was mapped with Addiction Severity Index interviews. Of these prisoners, 56% admitted previous use of AAS, of whom 24% declared to have committed violent crimes in connection with use of AAS. However, the only significant difference between users and nonusers with regard to criminal history when measured with the Addiction Severity Index was that the AAS users more often stated that they had been prosecuted for crimes labeled as “other crimes,” which did not include violent crimes. The reported side effects of AAS corresponded well to those previously reported. These results indicate that use of AAS is common among Swedish prisoners and that the motives and consequences of such use are similar to what has been observed in other AAS-using populations. Furthermore, this study supports earlier notions that misuse of AAS might cause violent behavior, but only in certain individuals and mainly in combination with other substances.

  • 3. Ruchkin, V V
    et al.
    Eisemann, M
    Hägglöf, B
    Cloninger, C R
    Interrelations between temperament, character, and parental rearing in male delinquent adolescents in northern Russia.1998Ingår i: Comprehensive Psychiatry, ISSN 0010-440X, E-ISSN 1532-8384, Vol. 39, nr 4, s. 225-30Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A comparison between 192 male delinquent adolescents and 121 controls from Northern Russia using the Temperament and Character Inventory (TCI) and Own Memories of Parental Rearing (EMBU) questionnaire on perceived parental rearing showed significant differences. The delinquent group had a higher level of Novelty Seeking, Harm Avoidance, and Self-transcendence, and also scored lower on Self-directedness. Delinquents who committed nonviolent crimes (thefts) appeared to have a higher level of Harm Avoidance compared with those who committed violent crimes (hooliganism, robbery, rape, and murder). As concerns perceived parental rearing practices, delinquents experienced more parental rejection and overprotection. Most of the personality dimensions were found to be highly correlated with the level of parental emotional warmth. Furthermore, both temperament traits and maternal rearing practices predicted the development of character dimensions. Findings are discussed in light of the interactive nature of parent-child relationships and of character development.

  • 4.
    Vermeiren, Robert
    et al.
    Yale Child Study Center.
    Schwab-Stone, Mary
    Yale Child Study Center.
    Ruchkin, Vladislav
    Yale Child Study Center.
    De Clippele, Antoine
    Deboutte, Dirk
    Predicting recidivism in delinquent adolescents from psychological and psychiatric assessment.2002Ingår i: Comprehensive Psychiatry, ISSN 0010-440X, E-ISSN 1532-8384, Vol. 43, nr 2, s. 142-9Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    An important but sparse body of research focuses on psychiatric disorders and/or psychological characteristics as predictors of recidivism in delinquent adolescents. Through detailed psychiatric and psychological assessment in 64 adjudicated male juvenile delinquents, the current study investigated the long-term relationships between psychopathology, intellectual functioning, and recidivism. Psychiatric diagnosis was based on the results of a semistructured interview conducted both with delinquents and their parents. After 2 years, information on recidivism was retrieved from the official records for the 64 subjects who underwent an initial assessment and the 36 who did not but who were adjudicated during the same period. The statistical model of future offending was able to explain 44.0% of the variance through the combination of (1) diagnosis of conduct disorder, (2) absence of major depression, and (3) low verbal IQ as scored on a standard intelligence test. It is concluded that specific aspects of psychiatric and psychological assessment can help to predict recidivist offending in delinquent adolescents. Future research should focus on the possibilities of implementing these findings in the development of prevention and rehabilitation programs.

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