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  • 1.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Biosensing platforms using graphene based bioreactive nanostructures with various dimensions2019Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Nanomaterials have brought new aspects and improvements to the biosensing field due to their unique physical and chemical properties that are not shown in the bulk state. This thesis focuses on concepting, developing and testing of biosensors where nanomaterials including graphene gold nanoparticles (AuNPs) and magnetic nanoparticles (MNPs) constitute the biosensors. The motivation is to improve the properties of biosensors for protein and nucleic acids by using the nanomaterials’ high surface volume ratio, their unique electrical properties, their good stability and biocompatibility.

    The synthesis of well controlled hybrid materials was essential to obtain well performing nucleic acids sensors, whereas a protein sensor contained mainly graphene and organic molecules. The nanomechanical measurements were applied on pyrene-maltose functionalized graphene surfaces after incubating them with the protein. When the Concanavalin A was captured by the pyrene-maltose, the adhesion force of biosensor surface increased significantly. This detection principle was employed to quantify the Concanavalin A attachment to the surface sensitively.

    In the development of the eletrocatalytic microRNA sensor, AuNPs were packaged into graphene oxide (GO) sheets to form three-dimensional network structures that both guide the electrical current and increase the surface area of the electrodes. Prior to the assembly of these GO-AuNPs hybrid materials, a duplex-specific nuclease-assisted target recycling reaction was employed for opening the surface of the DNA functionalized AuNPs. The electrocatalytical water splitting activity increased with the fraction of the AuNP surface and thus with the activity of the nuclease-assisted target recycling reaction.

    Owing to the high shape anisotropy of graphene, a two-dimensional optomagnetic label GO-MNP nanohybrid was investigated for DNA detection. The DNA coils that were generated through rolling circle amplification absorbed on GO-MNP nanohybrid, leading to a hydrodynamic size increase or aggregation of the proposed nanolabels that can be detected by an optomagnetic sensor. An MNP assembly-based microRNA biosensing strategy is also included in the thesis. DNA scaffolds of the MNP assemblies contain DNAzyme substrate and thus can form cleavage catalytic structures in the presence of microRNA, leading to the disintegration of assemblies. The proposed nanomaterials based biosensing platforms show great potential in the clinical and biomedical applications.

    Delarbeten
    1. Graphene Based Mechanical Biosensor by Employing Non-covalent Stacking Functionalization
    Öppna denna publikation i ny flik eller fönster >>Graphene Based Mechanical Biosensor by Employing Non-covalent Stacking Functionalization
    Visa övriga...
    2019 (Engelska)Ingår i: Artikel i tidskrift, Dagstidning (Övrigt vetenskapligt) Submitted
    Abstract [en]

    Herein we demonstrate a novel methodology to achieve mechanical biosensor by employing the distinguished interaction forces between the atomic force microscope (AFM) probe and sensor surfaces as the response signal. This mechanical biosensor is fabricated by utilizing the non-covalent π-π stacking of pyrene-maltose onto graphene surfaces with Concanavalin A (Con A) as a target protein. The atomic resolution scanning tunneling microscopy (STM) images indicate the successful formation of the self-assembled and densely packed pyrene-maltose layer on the sensor surface, which gives distinct atomic lattice structure as compared to pristine graphene. This mechanical biosensor exhibits detection of Con A with the sensitivity down to nanomolar level. Therefore, this proposed mechanical biosensor has the potential to be employed in a variety of bio-sensing applications.

    Nationell ämneskategori
    Nanoteknik Analytisk kemi
    Identifikatorer
    urn:nbn:se:uu:diva-378559 (URN)
    Tillgänglig från: 2019-03-06 Skapad: 2019-03-06 Senast uppdaterad: 2020-02-05Bibliografiskt granskad
    2. MicroRNA detection based on duplex-specific nuclease-assisted target recycling and gold nanoparticle/graphene oxide nanocomposite-mediated electrocatalytic amplification
    Öppna denna publikation i ny flik eller fönster >>MicroRNA detection based on duplex-specific nuclease-assisted target recycling and gold nanoparticle/graphene oxide nanocomposite-mediated electrocatalytic amplification
    Visa övriga...
    2019 (Engelska)Ingår i: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 127, s. 188-193Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    DNA technology based bio-responsive nanomaterials have been widely studied as promising tools for biomedical applications. Gold nanoparticles (AuNPs) and graphene oxide (GO) sheets are representative zero- and two-dimensional nanomaterials that have long been combined with DNA technology for point-of-care diagnostics. Herein, a cascade amplification system based on duplex-specific nuclease (DSN)-assisted target recycling and electrocatalytic water-splitting is demonstrated for the detection of microRNA. Target microRNAs can form DNA: RNA heteroduplexes with DNA probes on the surface of AuNPs, which can be hydrolyzed by DSN. MicroRNAs are preserved during the reaction and released into the suspension for the digestion of multiple DNA probes. After the DSN-based reaction, AuNPs are collected and mixed with GO to form AuNP/GO nanocomposite on an electrode for the following electrocatalytic amplification. The utilization of AuNP/GO nanocomposite offers large surface area, exceptional affinity to water molecules, and facilitated mass diffusion for the water-splitting reaction. For let-7b detection, the proposed biosensor achieved a limit detection of 1.5 fM in 80 min with a linear detection range of approximately four orders of magnitude. Moreover, it has the capability of discriminating non-target microRNAs containing even single-nucleotide mismatches, thus holding considerable potential for clinical diagnostics.

    Nyckelord
    Gold nanoparticles, Graphene oxide, MicroRNA detection, Electrocatalytic amplification, Duplex-specific nuclease
    Nationell ämneskategori
    Analytisk kemi Fysikalisk kemi
    Identifikatorer
    urn:nbn:se:uu:diva-377203 (URN)10.1016/j.bios.2018.12.027 (DOI)000457508800026 ()30611105 (PubMedID)
    Forskningsfinansiär
    Vetenskapsrådet, 2016-05259Knut och Alice Wallenbergs StiftelseEU, Horisont 2020, 713683
    Tillgänglig från: 2019-02-25 Skapad: 2019-02-25 Senast uppdaterad: 2019-04-24Bibliografiskt granskad
    3. MicroRNA Detection through DNAzyme-Mediated Disintegration of Magnetic Nanoparticle Assemblies
    Öppna denna publikation i ny flik eller fönster >>MicroRNA Detection through DNAzyme-Mediated Disintegration of Magnetic Nanoparticle Assemblies
    Visa övriga...
    2018 (Engelska)Ingår i: ACS Sensors, ISSN 2379-3694, Vol. 3, s. 1884-1891Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    DNA-assembled nanoparticle superstructures offer numerous bioresponsive properties that can be utilized for point-of-care diagnostics. Functional DNA sequences such as deoxyribozymes (DNAzymes) provide novel bioresponsive strategies and further extend the application of DNA-assembled nanoparticle superstructures. In this work, we describe a microRNA detection biosensor that combines magnetic nanoparticle (MNP) assemblies with DNAzyme-assisted target recycling. The DNA scaffolds of the MNP assemblies contain substrate sequences for DNAzyme and can form cleavage catalytic structures in the presence of target DNA or RNA sequences, leading to rupture of the scaffolds and disintegration of the MNP assemblies. The target sequences are preserved during the cleavage reaction and release into the suspension to trigger the digestion of multiple DNA scaffolds. The high local concentration of substrate sequences in the MNP assemblies reduces the diffusion time for target recycling. The concentration of released MNPs, which is proportional to the concentration of the target, can be quantified by a 405 nm laser-based optomagnetic sensor. For the detection of let-7b in 10% serum, after 1 h of isothermal reaction at 50 degrees C, we found a linear detection range between 10 pM and 100 nM with a limit of detection of 6 pM. For the quantification of DNA target in buffer solution, a limit of detection of 1.5 pM was achieved. Compared to protein enzyme-based microRNA detection methods, the proposed DNAzyme-based biosensor has an increased stability, a reduced cost and a possibility to be used in living cells, all of which are valuable features for biosensing applications.

    Nationell ämneskategori
    Analytisk kemi Teknik och teknologier
    Forskningsämne
    Teknisk fysik med inriktning mot fasta tillståndets fysik
    Identifikatorer
    urn:nbn:se:uu:diva-363317 (URN)10.1021/acssensors.8b00850 (DOI)000446276300038 ()30188122 (PubMedID)
    Forskningsfinansiär
    Forskningsrådet Formas, 221-2012-444Forskningsrådet Formas, 2011-1692EU, FP7, Sjunde ramprogrammet, 604448-NanoMag
    Tillgänglig från: 2018-10-16 Skapad: 2018-10-16 Senast uppdaterad: 2019-04-24Bibliografiskt granskad
    4. Self-Assembled Magnetic Nanoparticle−Graphene Oxide Nanotag for Optomagnetic Detection of DNA
    Öppna denna publikation i ny flik eller fönster >>Self-Assembled Magnetic Nanoparticle−Graphene Oxide Nanotag for Optomagnetic Detection of DNA
    Visa övriga...
    2019 (Engelska)Ingår i: Acs Applied Nano Materials, ISSN 2574-0970, Vol. 2, nr 3, s. 1683-1690Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    In this work, a two-dimensional self-assembled magnetic nanoparticle–graphene oxide (MNP-GO) nanocomposite is reported for the detection of DNA. Single-stranded DNA (ssDNA) coils, generated through a rolling circle amplification (RCA) reaction triggered by the hybridization of target oligos and padlock probes, have a strong interaction with MNP-GO nanotags through several mechanisms including π–π stacking, hydrogen bonding, van der Waals, electrostatic, and hydrophobic interactions. This interaction leads to a hydrodynamic size increase or aggregation of MNP-GO nanotags, which can be detected by a simple optomagnetic setup. Due to the high shape anisotropy, MNP-GO nanotags provide stronger optomagnetic signal than individual MNPs. Moreover, the avoidance of DNA probes (i.e., short ssDNA sequences as the biosensing receptor) provides easier material preparation and lower measurement cost. From real-time measurements of interactions between MNP-GO and RCA products amplified from a highly conserved Escherichia coli 16S rDNA sequence, a limit of detection of 2 pM was achieved with a total assay time of 90 min. Although the nonspecific binding force between GO and ssDNA is much weaker than the specific base-pairing force in a DNA duplex, the proposed method provides a detection limit similar to DNA probe-based magnetic biosensors, which can be ascribed to the abundant binding sites between GO and ssDNA. In addition, for target concentrations higher than 100 pM, the MNP-GO nanotags can be applied for a qualitative naked eye detection strategy based on nanotag–ssDNA flocculation.

    Ort, förlag, år, upplaga, sidor
    American Chemical Society (ACS), 2019
    Nyckelord
    Magnetic nanoparticles; graphene oxide; rolling circle amplification; single stranded DNA detection; optomagnetic sensing
    Nationell ämneskategori
    Nanoteknik Analytisk kemi
    Forskningsämne
    Analytisk kemi
    Identifikatorer
    urn:nbn:se:uu:diva-378551 (URN)10.1021/acsanm.9b00127 (DOI)000462554000061 ()
    Tillgänglig från: 2019-03-06 Skapad: 2019-04-24 Senast uppdaterad: 2020-02-24Bibliografiskt granskad
    5. Size-dependent elasticity of gold nanoparticle measured by atomic force microscope based nanoindentation
    Öppna denna publikation i ny flik eller fönster >>Size-dependent elasticity of gold nanoparticle measured by atomic force microscope based nanoindentation
    2019 (Engelska)Ingår i: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 115, nr 5, artikel-id 053104Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    The elasticity is one of the key properties in gold nanoparticles (AuNPs) and plays an essential role in the process design and applications. In this work, we have proposed an Argon plasma based technique to obtain well dispersed and neat AuNPs without surface functional groups. Our investigation on the size-dependent elasticity focused on the AuNPs with the size ranging from 2 nm to 12 nm by using atomic force microscope based nanoindentation technique under the peakforce quantitative nanomechanical mapping mode. The results show clearly that when the AuNPs are smaller than 6 nm, there is a significant increase in the elasticity as the smallest nanoparticles displacing an elastic modulus of ~140 GPa.  Our result provides important experimental evidence that contributes to a better understanding of the size-property relations as well as process design in AuNPs, and it also can be applied to measure the mechanical properties in a wide range of nano-objects.

    Nationell ämneskategori
    Nanoteknik
    Identifikatorer
    urn:nbn:se:uu:diva-378556 (URN)10.1063/1.5095182 (DOI)000478913700003 ()
    Anmärkning

    Hu Li and Yuanyuan Han contributed equally to this work.

    Manuscript version in thesis list of papers did not include Tianbo Duan as author.

    Tillgänglig från: 2019-03-06 Skapad: 2019-03-06 Senast uppdaterad: 2019-09-24Bibliografiskt granskad
  • 2.
    Han, Yuanyuan
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Li, Hu
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Jafri, Syed Hassan Mujtaba
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Ossipov, Dmitri A.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Hilborn, Jöns
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    LEIFER, KLAUS
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Graphene Based Mechanical Biosensor by Employing Non-covalent Stacking Functionalization2019Ingår i: Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [en]

    Herein we demonstrate a novel methodology to achieve mechanical biosensor by employing the distinguished interaction forces between the atomic force microscope (AFM) probe and sensor surfaces as the response signal. This mechanical biosensor is fabricated by utilizing the non-covalent π-π stacking of pyrene-maltose onto graphene surfaces with Concanavalin A (Con A) as a target protein. The atomic resolution scanning tunneling microscopy (STM) images indicate the successful formation of the self-assembled and densely packed pyrene-maltose layer on the sensor surface, which gives distinct atomic lattice structure as compared to pristine graphene. This mechanical biosensor exhibits detection of Con A with the sensitivity down to nanomolar level. Therefore, this proposed mechanical biosensor has the potential to be employed in a variety of bio-sensing applications.

  • 3.
    Han, Yuanyuan
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för materialvetenskap, Tillämpad materialvetenskap.
    Li, Hu
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för materialvetenskap, Tillämpad materialvetenskap. Univ Manchester, Sch Elect & Elect Engn, Manchester M13 9PL, Lancs, England.
    Jafri, Syed Hassan Mujtaba
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för materialvetenskap, Tillämpad materialvetenskap. Mirpur Univ Sci & Technol, Dept Elect Engn, Mirpur 10250, Azad Jammu & Ka, Pakistan.
    Ossipov, Dmitri A.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström. Karolinska Inst, Dept Biosci & Nutr, S-17177 Stockholm, Sweden.
    Hilborn, Jöns
    Karolinska Inst, Dept Biosci & Nutr, S-17177 Stockholm, Sweden.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för materialvetenskap, Tillämpad materialvetenskap.
    Optimization and analysis of pyrene-maltose functionalized graphene surfaces for Con A detection2020Ingår i: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 510, artikel-id 145409Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Utilizing the non-covalent pi-pi stacking of pyrene functionalized molecules onto graphene surfaces has achieved great success in the detection of various bio-objects, while the fundamental investigations on surface modifications stills remain rarely exploited. Here, we report the nano and atomic scale analysis of the pi-pi stacking functionalized graphene surface regarding to its surface topography, molecular self-assembly as well as process optimizations. The 'amphipathic' molecule, pyrene-maltose, is used for the non-covalent functionalization of graphene and systematical analysis is performed to understand the influence of different solvents on the molecular surface arrangement. Atomic force microscopy (AFM) and spectroscopy analysis indicate the successful formation of pyrene-maltose layer on graphene surface and it is further confirmed by scanning tunneling microscopy, depicting the self-assembled and densely packed pyrene-maltose layer that give distinguished and ordered diamond-shape lattice as compared to triangular lattice in pristine graphene. We also demonstrated that the interfacial adhesion forces between the AFM probe and the functionalized surfaces allow the detection of the lectin protein Concavalin A through selective absorption. This work provides essential evidence of the pi-pi interactions between pyrene molecules and graphene, and the AFM based adhesion measurement also has the potential to be employed in a variety of bio-detection applications.

  • 4.
    Han, Yuanyuan
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Qiu, Zhen
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Nawale, Ganesh N.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
    Varghese, Oommen P.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
    Hilborn, Jöns
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
    Tian, Bo
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik. Tech Univ Denmark, Dept Micro & Nanotechnol, DK-2800 Kongens Lyngby, Denmark.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    MicroRNA detection based on duplex-specific nuclease-assisted target recycling and gold nanoparticle/graphene oxide nanocomposite-mediated electrocatalytic amplification2019Ingår i: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 127, s. 188-193Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    DNA technology based bio-responsive nanomaterials have been widely studied as promising tools for biomedical applications. Gold nanoparticles (AuNPs) and graphene oxide (GO) sheets are representative zero- and two-dimensional nanomaterials that have long been combined with DNA technology for point-of-care diagnostics. Herein, a cascade amplification system based on duplex-specific nuclease (DSN)-assisted target recycling and electrocatalytic water-splitting is demonstrated for the detection of microRNA. Target microRNAs can form DNA: RNA heteroduplexes with DNA probes on the surface of AuNPs, which can be hydrolyzed by DSN. MicroRNAs are preserved during the reaction and released into the suspension for the digestion of multiple DNA probes. After the DSN-based reaction, AuNPs are collected and mixed with GO to form AuNP/GO nanocomposite on an electrode for the following electrocatalytic amplification. The utilization of AuNP/GO nanocomposite offers large surface area, exceptional affinity to water molecules, and facilitated mass diffusion for the water-splitting reaction. For let-7b detection, the proposed biosensor achieved a limit detection of 1.5 fM in 80 min with a linear detection range of approximately four orders of magnitude. Moreover, it has the capability of discriminating non-target microRNAs containing even single-nucleotide mismatches, thus holding considerable potential for clinical diagnostics.

  • 5.
    Johansson, Fredrik
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Cappel, Ute B.
    Fondell, Mattis
    Han, Yuanyuan
    Gorgoi, Mihaela
    Leifer, Klaus
    Lindblad, Andreas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Tailoring Ultra-fast Charge Transfer in MoS2Manuskript (preprint) (Övrigt vetenskapligt)
  • 6.
    Li, Hu
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap. School of Electrical and Electronic Engineering, University of Manchester, United Kingdom.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Duan, Tianbo
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Size-dependent elasticity of gold nanoparticle measured by atomic force microscope based nanoindentation2019Ingår i: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 115, nr 5, artikel-id 053104Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The elasticity is one of the key properties in gold nanoparticles (AuNPs) and plays an essential role in the process design and applications. In this work, we have proposed an Argon plasma based technique to obtain well dispersed and neat AuNPs without surface functional groups. Our investigation on the size-dependent elasticity focused on the AuNPs with the size ranging from 2 nm to 12 nm by using atomic force microscope based nanoindentation technique under the peakforce quantitative nanomechanical mapping mode. The results show clearly that when the AuNPs are smaller than 6 nm, there is a significant increase in the elasticity as the smallest nanoparticles displacing an elastic modulus of ~140 GPa.  Our result provides important experimental evidence that contributes to a better understanding of the size-property relations as well as process design in AuNPs, and it also can be applied to measure the mechanical properties in a wide range of nano-objects.

  • 7.
    Li, Hu
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Wani, Ishtiaq Hassan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Anumol, Ashok
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Jafri, Syed Hassan Mujtaba
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Somobrata, Acharya
    Centre for Advanced Materials (CAM) , Indian Association for the Cultivation of Science, India.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Enhanced gas sensing performance of graphene/ZnS-CdS hetero-nanowires gas sensor synthesized by Langmuir-Blodgett self-assembly method2017Ingår i: Journal of Physics Conference Series, ISSN 1742-6588, Vol. 922, artikel-id 012023Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Graphene is a promising material in the field of solid-state gas sensors due to the unique two-dimensional structure. Here, we have shown by fabricating graphene/ZnS-CdS hetero-nanowire structure, the gas sensor sensitivity has a two-fold increase to 20% under 15 ppm gaseous concentration compared to a 10% response in pristine graphene. Spectroscopy and microscopy analysis indicate that the semi-conducting ZnS-CdS hetero-nanowires are 2 nm wide and densely packed on top of graphene. By combining UV illumination, the device approaches a fast response/recovery and high gas sensitivity, thus has a potential to be used in a detection of wide range of gases. 

  • 8.
    Lundstedt, Anna
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC.
    Papadakis, Raffaello
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Molekylär biomimetik.
    Li, Hu
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Bergman, Joakim
    AstraZeneca R&D Mölndal, Medicinal Chemistry.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Grennberg, Helena
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC.
    Ottosson, Henrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Molekylär biomimetik.
    White-light photoassisted covalent functionalization of graphene using 2-propanol2017Ingår i: Small Methods, ISSN 2366-9608, Vol. 1, nr 11, artikel-id 1700214Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Herein, a photochemical method for functionalization of graphene using 2-propanol is reported. The functionalization method which is catalyst-free operates at ambient temperature in neat 2-propanol under an inert atmosphere of argon. The equipment requirement is a white-light source for the irradiation. The same methodology when applied to kish graphite results in a novel material, exhibiting significantly higher wettability than the starting material according to water contact angle measurements. Furthermore, the materials generated from both graphene and kish graphite exhibit increased adhesion energy, attributed to the fixation of isopropyl alcohol fragments onto graphene and graphite, respectively. The presence of hydroxyl groups and the possibility for further reactions on the functionalized graphene material are demonstrated through a substitution reaction with thionyl chloride, where the hydroxyl groups are replaced with chlorides, as confirmed through X-ray photoelectron spectroscopy analysis.

  • 9.
    Qin, Tao
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Zhang, Peng
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    A novel method to synthesize low-cost phosphate-based particles from natural water2017Ingår i: Materials letters (General ed.), ISSN 0167-577X, E-ISSN 1873-4979, Vol. 206, s. 178-181Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Calcium phosphate (CaP) and magnesium phosphate (MgP) are widely used as biomaterials. A novel method for low-cost manufacturing of calcium phosphate spheres and magnesium phosphate micro particles was studied. The method focuses on novel strategies of utilizing seawater and lake water. In the natural water, the molar ratios of Mg/Ca are constant. The morphologies of the particles are determined by ratio of Ca/P. This simple method provides a prototype to synthesize low-cost inorganic spheres with natural water, which facilitate large-scale production.

  • 10.
    Qin, Tao
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Zhang, Peng
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    The formation of calcium fluoride microspheres via solubility equilibrium2017Ingår i: Ceramics International, ISSN 0272-8842, E-ISSN 1873-3956, Vol. 43, nr 16, s. 14521-14524Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The focus of this study is on synthesis and mechanism of calcium fluoride (CaF2) spheres. Magnesium is the decisive factor in the formation of the spheres. The solubility product constant of Mg1-xCaxF2 is higher than those of CaF2 and MgF2. The structure of particles evolved to being spherical due to solubility equilibrium. The calcium fluoride spheres have great potential as dental materials in bleaching products.

  • 11.
    Qin, Tao
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Zhang, Peng
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Wani, Ishtiaq Hassan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Nikolajeff, Fredrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap. Uppsala Univ, Dept Engn Sci, Div Appl Mat Sci, Angstromlab, Lagerhyddsvagen 1, S-75237 Uppsala, Sweden..
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Template-free synthesis of phosphate-based spheres via modified supersaturated phosphate buffer solutions2017Ingår i: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 28, nr 7, artikel-id 99Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Modified supersaturated phosphate buffer solutions were used to synthesize phosphate-based spheres, including calcium phosphate (CaP), strontium phosphate (SrP) and barium phosphate (BaP). A series of ions concentrations in the modified phosphate buffer solutions were investigated in order to study their effects in precipitates morphologies. During synthesis, it was found that magnesium was the key factor in sphere formation. The morphologies of calcium phosphate, strontium phosphate and barium phosphate precipitates varied as the concentration of magnesium ions varied. When sufficient magnesium was provided, the precipitates appeared spherical, and the diameter was in range of 0.5-2 mu m. The morphologies, compositions and structure of spheres were characterized by x-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and N-2 adsorption analysis. Moreover, the application of magnesium substituted calcium phosphate spheres in dentin tubules occlusion was investigated.

  • 12.
    Qin, Tao
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Zhang, Peng
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Wani, Ishtiaq Hassan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    LEIFER, KLAUS
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Nikolajeff, Fredrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    A general strategy for template-free and low-cost synthesis of inorganic hollow spheres2017Ingår i: Powder Technology, ISSN 0032-5910, E-ISSN 1873-328X, Vol. 319, s. 163-171Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Inorganic hollow spheres have a great potential in many fields, such as calcium phosphate (Ca3(PO4)2) as carriers of active ingredients and local delivery. They are typically synthesized by the methods that reply on template-based strategies. However, the template residue and energy consumption during template removal are drawbacks. Currently developed template-free methods remain challenges such as time, cost and complicated procedures. In this paper, we introduce a general low-cost and template-free precipitation method with simple procedure. A series of inorganic hollow spheres, including calcium phosphate, calcium fluoride, strontium phosphate, strontium fluoride, barium phosphate and barium fluoride via magnesium were successfully synthesized, respectively. Based on these experimental results, a new model is proposed to explain the mechanism of the hollow inorganic spheres formation. This paper provides a general method to synthesize inorganic hollow spheres, which may have an important indication to other systems.

  • 13.
    Shi, Liyang
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Hilborn, Jöns
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
    Ossipov, Dmitri
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
    “Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry2016Ingår i: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 52, nr 74, s. 11151-11154Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium–bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.

  • 14.
    Tian, Bo
    et al.
    Tech Univ Denmark, Dept Hlth Technol DTU Hlth Tech, Lyngby, Denmark.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Fock, Jeppe
    Blusense Diagnost, Copenhagen, Denmark.
    Strömberg, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Fougt Hansen, Mikkel
    Tech Univ Denmark, Dept Hlth Technol DTU Hlth Tech, Lyngby, Denmark.
    Self-Assembled Magnetic Nanoparticle−Graphene Oxide Nanotag for Optomagnetic Detection of DNA2019Ingår i: Acs Applied Nano Materials, ISSN 2574-0970, Vol. 2, nr 3, s. 1683-1690Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this work, a two-dimensional self-assembled magnetic nanoparticle–graphene oxide (MNP-GO) nanocomposite is reported for the detection of DNA. Single-stranded DNA (ssDNA) coils, generated through a rolling circle amplification (RCA) reaction triggered by the hybridization of target oligos and padlock probes, have a strong interaction with MNP-GO nanotags through several mechanisms including π–π stacking, hydrogen bonding, van der Waals, electrostatic, and hydrophobic interactions. This interaction leads to a hydrodynamic size increase or aggregation of MNP-GO nanotags, which can be detected by a simple optomagnetic setup. Due to the high shape anisotropy, MNP-GO nanotags provide stronger optomagnetic signal than individual MNPs. Moreover, the avoidance of DNA probes (i.e., short ssDNA sequences as the biosensing receptor) provides easier material preparation and lower measurement cost. From real-time measurements of interactions between MNP-GO and RCA products amplified from a highly conserved Escherichia coli 16S rDNA sequence, a limit of detection of 2 pM was achieved with a total assay time of 90 min. Although the nonspecific binding force between GO and ssDNA is much weaker than the specific base-pairing force in a DNA duplex, the proposed method provides a detection limit similar to DNA probe-based magnetic biosensors, which can be ascribed to the abundant binding sites between GO and ssDNA. In addition, for target concentrations higher than 100 pM, the MNP-GO nanotags can be applied for a qualitative naked eye detection strategy based on nanotag–ssDNA flocculation.

  • 15.
    Tian, Bo
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Wetterskog, Erik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Donolato, Marco
    BluSense Diagnostics, Copenhagen, Denmark.
    Fougt Hansen, Mikkel
    Technical University of Denmark.
    Svedlindh, Peter
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Strömberg, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    MicroRNA Detection through DNAzyme-Mediated Disintegration of Magnetic Nanoparticle Assemblies2018Ingår i: ACS Sensors, ISSN 2379-3694, Vol. 3, s. 1884-1891Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    DNA-assembled nanoparticle superstructures offer numerous bioresponsive properties that can be utilized for point-of-care diagnostics. Functional DNA sequences such as deoxyribozymes (DNAzymes) provide novel bioresponsive strategies and further extend the application of DNA-assembled nanoparticle superstructures. In this work, we describe a microRNA detection biosensor that combines magnetic nanoparticle (MNP) assemblies with DNAzyme-assisted target recycling. The DNA scaffolds of the MNP assemblies contain substrate sequences for DNAzyme and can form cleavage catalytic structures in the presence of target DNA or RNA sequences, leading to rupture of the scaffolds and disintegration of the MNP assemblies. The target sequences are preserved during the cleavage reaction and release into the suspension to trigger the digestion of multiple DNA scaffolds. The high local concentration of substrate sequences in the MNP assemblies reduces the diffusion time for target recycling. The concentration of released MNPs, which is proportional to the concentration of the target, can be quantified by a 405 nm laser-based optomagnetic sensor. For the detection of let-7b in 10% serum, after 1 h of isothermal reaction at 50 degrees C, we found a linear detection range between 10 pM and 100 nM with a limit of detection of 6 pM. For the quantification of DNA target in buffer solution, a limit of detection of 1.5 pM was achieved. Compared to protein enzyme-based microRNA detection methods, the proposed DNAzyme-based biosensor has an increased stability, a reduced cost and a possibility to be used in living cells, all of which are valuable features for biosensing applications.

  • 16.
    Wani, Ishtiaq Hassan
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Li, Hu
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Grigoriev, Anton
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik.
    Orthaber, Andreas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Molekylär biomimetik. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Oorganisk kemi.
    Calard, Francois
    Niebel, C
    Jarrosson, T
    Serein-Spirau, Francoise
    Jafri, Syed Hassan Mujtaba
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    LEIFER, KLAUS
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Investigation of the factors that affect the fabrication of highly conducting NP-molecule junctions inside sub 20 nm molecular electronic devices.Manuskript (preprint) (Övrigt vetenskapligt)
  • 17.
    Yang, Jiaojiao
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Han, Yuanyuan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Luo, Jun
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Liefer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Synthesis and Characterization of Amorphous Magnesium Carbonate Nanoparticles2019Ingår i: Materials Chemistry and Physics, ISSN 0254-0584, E-ISSN 1879-3312, Vol. 224, s. 301-307Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We report the template-free, low-temperature, environment-friendly synthesis of amorphous magnesium carbonate nanoparticles (AMN). Scanning electron microscopy and transmission electron microscopy show that AMN consist of small nanoparticles approximately 20-65 nm in diameter. Drying temperature and centrifugation are shown to affect the nanostructure and functional properties of the material. Aggregated AMN can be produced with a total pore volume up to 1.72 cm(3)/g and can absorb as much as 24 mmol/g water, substantially surpassing the pore volume and moisture-absorbing capacity of all previously described alkali earth metal carbonates. The nanoparticles are foreseen to be useful in applications such as water sorption, drug delivery and catalysis.

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