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  • 101.
    Junus, Katja
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Wikström, Anna-Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa. Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Olovsson, Matts
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Early second-trimester plasma levels of NT-proBNP in women who subsequently develop early-onset preeclampsia2017Inngår i: The Journal of Maternal-Fetal & Neonatal Medicine, ISSN 1476-7058, E-ISSN 1476-4954, Vol. 30, nr 18, s. 2163-2165Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Plasma levels of NT-proBNP are elevated in women with preeclampsia at the time of diagnosis. The objective of this case-control study was to evaluate N-terminal proBNP (NT-proBNP) in maternal plasma as an early second-trimester biomarker for prediction of early-onset preeclampsia. In early second-trimester samples, women who later developed preeclampsia at gestational age 34 wk + 0 or earlier (n = 16) had similar plasma levels of NT-proBNP (median 51.8, range 26.1-131.9 pg/ml) as women with uncomplicated pregnancy outcomes (n = 43) (53.0, 14.9-184.2 pg/ml). The early second-trimester level of NT-proBNP cannot therefore be used as a predictive biomarker of early-onset preeclampsia.

  • 102.
    Junus, Katja
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Obstetrik & gynekologi.
    Wikström, Anna-Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Obstetrik & gynekologi.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Olovsson, Matts
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Obstetrik & gynekologi.
    Placental Expression of proBNP/NT-proBNP and Plasma Levels of NT-proBNP in Early- and Late-Onset Preeclampsia2014Inngår i: American Journal of Hypertension, ISSN 0895-7061, E-ISSN 1941-7225, Vol. 27, nr 9, s. 1225-1230Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Levels of plasma N-terminal pro B-type natriuretic peptide (NT-proBNP) are elevated in preeclampsia. In this study, the possibility that the placenta produces and releases proBNP/NT-proBNP was explored. Plasma levels of NT-proBNP in early- and late-onset preeclampsia were also measured.

    METHODS: Placental proBNP mRNA in early-onset preeclampsia (n = 7), late-onset preeclampsia (n = 8), and controls of similar gestational age (n = 10) was assessed by quantitative real-time polymerase chain reaction. ProBNP/NT-proBNP protein was studied in placental samples with immunohistochemistry (n = 8) and tissue culture (n = 2). Plasma levels of NT-proBNP were measured in early-onset preeclampsia (n = 18), late-onset preeclampsia (n = 20), and relevant controls (n = 36).

    RESULTS: Transcripts of proBNP mRNA were found in 20 out of 25 samples, there were no differences in expression between the groups. ProBNP/NT-proBNP protein was observed in maternal spiral arteries and in syncytiotrophoblasts in all placental samples. After placental tissue culture, there were measurable amounts of NT-proBNP in the culture media. Women with both early- (365 [14-9815] pg/ml) and late-onset preeclampsia (176 [33-2547] pg/ml) had higher levels of NT-proBNP than their controls (P < 0.001). There was a tendency toward higher levels of NT-proBNP in women with early-onset preeclampsia than in women with late-onset preeclampsia (P = 0.057).

    CONCLUSION: The results indicate possible placental production and release of proBNP/NT-proBNP into the maternal circulation.

  • 103.
    Karawajczyk, Malgorzata
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Haile, Saba
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Grabski, Magnus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    The HemoCue WBC DIFF system could be used for leucocyte and neutrophil counts but not for full differential counts2017Inngår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, nr 6, s. 974-978Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    AIM: The aim of this study was to evaluate the HemoCue WBC DIFF system for point of care testing of fingerstick samples from paediatric patients.

    METHODS: We analysed 158 white blood cell counts on both the point of care HemoCue WBC DIFF instrument and the Cell Dyn Sapphire cell counter used by our central laboratory and compared the results. The measurements were performed using fingerstick samples drawn by nurses working in paediatric emergency and paediatric oncology units.

    RESULTS: There was good agreement between the two instruments for white blood cell and neutrophil counts. The correlation was weaker for lymphocytes and the correlations were poor for monocytes and eosinophils. The HemoCue WBC DIFF flagged 56 of the 148 capillary drawn samples as abnormal, but none of the 10 venously collected samples. Only two of the flagged samples differed significantly between the instruments, with regard to the cell counts.

    CONCLUSION: The correlations between the white blood cell counts and neutrophil counts in this real life study were good enough to diagnose children in emergency department and oncology unit settings. However, the high number of pathological flags from fingerstick samples, which made reruns necessary, limited the usefulness of the instrument.

  • 104.
    Karawajczyk, Malgorzata
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Peterson, Christer G. B.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Venge, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Garcia, Rodolfo C.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    An Extragranular Compartment of Blood Eosinophils Contains Eosinophil Protein X/Eosinophil-Derived Neurotoxin (EPX/EDN)2013Inngår i: Inflammation, ISSN 0360-3997, E-ISSN 1573-2576, Vol. 36, nr 2, s. 320-329Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Serum and plasma profiles of eosinophil protein X (EPX/EDN) and those of other eosinophil proteins differ in various conditions, suggesting a different mobilisation from storage granules. This work studied the subcellular localisation of EPX/EDN in non-primed and in vivo primed blood eosinophils from healthy and allergic subjects, during and out of the pollen season. Primed eosinophils contain easily mobilisable secretory proteins. By fractionation on sucrose density gradients, EPX/EDN localised in the specific granules as well as in a cytoplasmic extra-granular compartment of low equilibrium density that partially overlapped with vesicular structures, cytosolic proteins and plasma membranes. This compartment was clearly separate from the low density peak of ECP that increases during the pollen season. There were no significant differences in the amounts of EPX/EDN present in the low density peak of healthy and allergic subjects. Immuno-gold labelling electron microscopy showed EPX/EDN in specific granules, cytoplasm and associated to plasma membranes. In conclusion, substantial amounts of EPX/EDN localise in an extra-granular, low equilibrium density compartment of human eosinophils.

  • 105.
    Karlsson, J
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Helmersson-Karlqvist, Johanna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Delayed mixing of vacuum tubes clearly affects platelet counts but not haemoglobin concentration and prothrombin time (INR) results2013Inngår i: International Journal of Laboratory Hematology, ISSN 1751-5521, E-ISSN 1751-553X, Vol. 35, nr 6, s. E15-E17Artikkel i tidsskrift (Annet vitenskapelig)
  • 106.
    Kassebaum, Nicholas J.
    et al.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Barber, Ryan M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Bhutta, Zulfiqar A.
    Aga Khan Univ, Ctr Excellence Women & Child Hlth, Karachi, Pakistan.;Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Dandona, Lalit
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Publ Hlth Fdn India, New Delhi, India..
    Gething, Peter W.
    Univ Oxford, Dept Zool, Oxford, England..
    Hay, Simon I.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kinfu, Yohannes
    Univ Canberra, Fac Hlth, Ctr Res & Act Publ Hlth, Canberra, ACT, Australia..
    Larson, Heidi J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London, England..
    Liang, Xiaofeng
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Lim, Stephen S.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Lopez, Alan D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia..
    Lozano, Rafael
    Mensah, George A.
    Mokdad, Ali H.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Naghavi, Mohsen
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Pinho, Christine
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Salomon, Joshua A.
    Steiner, Caitlyn
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Vos, Theo
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Wang, Haidong
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Abajobir, Amanuel Alemu
    Abate, Kalkidan Hassen
    Abbas, Kaja M.
    Abd-Allah, Foad
    Abdallat, Mahmud A.
    Abdulle, Abdishakur M.
    Abera, Semaw Ferede
    Aboyans, Victor
    Abubakar, Ibrahim
    Abu-Rmeileh, Niveen M. E.
    Achoki, Tom
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Adebiyi, Akindele Olupelumi
    Univ Ibadan, Coll Med, Ibadan, Nigeria.;Univ Coll Hosp, Ibadan, Nigeria..
    Adedeji, Isaac Akinkunmi
    Olabisi Onabanjo Univ, Ago Iwoye, Nigeria..
    Adelekan, Ademola Lukman
    Univ Ibadan, Ibadan, Nigeria.;Publ Hlth Promot Alliance, Osogbo, Nigeria..
    Adou, Arsene Kouablan
    Assoc Ivoirienne Bien Etre Familial, Abidjan, Cote Ivoire..
    Afanvi, Kossivi Agbelenko
    Direct Dist Sanitaire Haho, Notse, Togo.;Univ Lome, Fac Sci Sante, Lome, Togo..
    Agarwal, Arnav
    Univ Toronto, Toronto, ON, Canada.;McMaster Univ, Hamilton, ON, Canada..
    Kiadaliri, Aliasghar Ahmad
    Lund Univ, Clin Epidemiol Unit, Orthoped, Dept Clin Sci Lund, Lund, Sweden.;Kerman Univ Med Sci, Inst Futures Studies Hlth, Hlth Serv Management Res Ctr, Kerman, Iran..
    Ajala, Oluremi N.
    Univ Pittsburgh, Med Ctr, Mckeesport, PA USA..
    Akinyemiju, Tomi F.
    Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA. Univ Alabama Birmingham, Birmingham, AL USA..
    Akseer, Nadia
    Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada.;Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada..
    Al-Aly, Ziyad
    Washington Univ, St Louis, MO USA..
    Alam, Khurshid
    Univ Melbourne, Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.;Univ Sydney, Sydney, NSW, Australia..
    Alam, Noore K. M.
    Queensland Hlth, Herston, Qld, Australia..
    Alasfoor, Deena
    Minist Hlth, Al Khuwair, Oman..
    Aldhahri, Saleh Fahed
    King Saud Univ, Riyadh, Saudi Arabia. King Fahad Med City, Dept Anesthesiol, Riyadh, Saudi Arabia.;King Fahad Med City, Riyadh, Saudi Arabia..
    Aldridge, Robert William
    Alhabib, Samia
    King Abdullah Bin Abdulaziz Univ Hosp, Riyadh, Saudi Arabia..
    Ali, Raghib
    Univ Oxford, Oxford, England..
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Strassen, Luxembourg..
    Alla, Francois
    Univ Lorraine, Sch Publ Hlth, Nancy, France..
    Al-Raddadi, Rajaa
    Minist Hlth, Jeddah, Saudi Arabia..
    Alsharif, Ubai
    Charite, Berlin, Germany..
    Martin, Elena Alvarez
    Minist Hlth Social Policy & Equal, Govt Delegat Natl Plan Drugs, Spanish Observ Drugs, Madrid, Spain..
    Alvis-Guzman, Nelson
    Univ Cartagena, Cartagena De Indias, Colombia..
    Amare, Azmeraw T.
    Univ Adelaide, Sch Med, Adelaide, SA, Australia.;Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia. Bahir Dar Univ, Bahir Dar, Ethiopia..
    Amberbir, Alemayehu
    Dignitas Int, Zomba, Malawi..
    Amegah, Adeladza Kofi
    Univ Cape Coast, Cape Coast, Ghana..
    Ammar, Walid
    Minist Publ Hlth, Beirut, Lebanon..
    Amrock, Stephen Marc
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Andersen, Hjalte H.
    Aalborg Univ, Fac Med, Dept Hlth Sci & Technol, Ctr Sensory Motor Interact, Aalborg, Denmark..
    Anderson, Gregory M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Antoine, Rose Mayerline
    Rose Fdn Haiti, Portau Au Prince, Haiti..
    Antonio, Carl Abelardo T.
    Univ Philippines, Coll Publ Hlth, Dept Hlth Policy & Adm, Manila, Philippines..
    Aregay, Atsede Fantahun
    Ärnlöv, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi. Dalarna Univ, Falun, Sweden..
    Arora, Megha
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Arsenijevic, Valentina S. Arsic
    Univ Belgrade, Sch Med, Inst Microbiol & Immunol, Belgrade, Serbia.;Univ Childrens Hosp, Belgrade, Serbia..
    Artaman, Al
    Asayesh, Hamid
    Qom Univ Med Sci, Sch Paramed, Dept Emergency Med, Qom, Iran..
    Atique, Suleman
    Taipei Med Univ, Grad Inst Biomed Informat, Taipei, Taiwan..
    Avokpaho, Euripide Frinel G. Arthur
    Inst Rech Clin Benin, Cotonou, Benin.;LERAS Afrique, Parakou, Benin..
    Awasthi, Ashish
    Sanjay Gandhi Postgraduate Inst Med Sci, Lucknow, Uttar Pradesh, India..
    Quintanilla, Beatriz Paulina Ayala
    La Trobe Univ, Judith Lumley Ctr Mother Infant & Family Hlth Res, Melbourne, Vic, Australia.;Peruvian Natl Inst Hlth, Lima, Peru..
    Azzopardi, Peter
    Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia.;Univ Melbourne, Childrens Res Inst, Melbourne, Vic, Australia.;South Australian Hlth & Med Res Inst, Wardliparingga Aboriginal Res Unit, Adelaide, SA, Australia..
    Bacha, Umar
    Univ Management & Technol, Sch Hlth Sci, Lahore, Pakistan..
    Badawi, Alaa
    Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON, Canada.;Publ Hlth Agcy Canada, Toronto, ON, Canada..
    Bahit, Maria C.
    INECO Neurociencias, Rosario, Santa Fe, Argentina..
    Balakrishnan, Kalpana
    Sri Ramachandra Univ, Chennai, Tamil Nadu, India..
    Banerjee, Amitava
    Barac, Aleksandra
    Univ Belgrade, Fac Med, Belgrade, Serbia..
    Barker-Collo, Suzanne L.
    Univ Auckland, Sch Psychol, Auckland, New Zealand..
    Barnighausen, Till
    Africa Hlth Res Inst, Mtubatuba, South Africa.;Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Basu, Sanjay
    Stanford Univ, Stanford, CA 94305 USA..
    Bayou, Tigist Assefa
    Bayou, Yibeltal Tebekaw
    Jhpiego Ethiopia, Addis Ababa, Ethiopia..
    Bazargan-Hejazi, Shahrzad
    Charles R Drew Univ Med & Sci, 1621 E 120th St, Los Angeles, CA 90059 USA.;Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.;Kermanshah Univ Med Sci, Kermanshah, Iran..
    Beardsley, Justin
    Univ Oxford, Ho Chi Minh City, Vietnam..
    Bedi, NeerajHaidong Wang
    Coll Publ Hlth & Trop Med, Jazan, Saudi Arabia..
    Bekele, Tolesa
    Madawalabu Univ, Bale Goba, Ethiopia..
    Bell, Michelle L.
    Yale Univ, New Haven, CT USA..
    Bennett, Derrick A.
    Univ Oxford, Oxford, England..
    Bensenor, Isabela M.
    Berhane, Adugnaw
    Debre Berhane Univ, Debre Berhan, Ethiopia..
    Bernabe, Eduardo
    Betsu, Balem Demtsu
    Beyene, Addisu Shunu
    Haramaya Univ, Harar, Ethiopia..
    Biadgilign, Sibhatu
    Bikbov, Boris
    Academician VI Shumakov Fed Res Ctr Transplantol, Dept Nephrol Issues Transplanted Kidney, Moscow, Russia..
    Bin Abdulhak, Aref A.
    Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA..
    Biroscak, Brian J.
    Yale Univ, New Haven, CT USA.;Univ S Florida, Tampa, FL USA..
    Biryukov, Stan
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Bisanzio, Donal
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Bjertness, Espen
    Blore, Jed D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Brainin, Michael
    Danube Univ Krems, Krems, Austria..
    Brazinova, Alexandra
    Breitborde, Nicholas J. K.
    Brugha, Traolach S.
    Butt, Zahid A.
    Campos-Nonato, Ismael Ricardo
    Campuzano, Julio Cesar
    Cardenas, Rosario
    Carrero, Juan Jesus
    Carter, Austin
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Casey, Daniel C.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Castaneda-Oquela, Carlos A.
    Castro, Ruben Estanislao
    Catala-Lopez, Ferran
    Cavalleri, Fiorella
    Chang, Hsing-Yi
    Chang, Jung -Chen
    Chavan, Laxmikant
    Chibueze, Chioma Ezinne
    Chisumpa, Vesper Hichilombwe
    Choi, Jee-Young Jasmine
    Chowdhury, Rajiv
    Christopher, Devasahayam Jesudas
    Ciobanu, Liliana G.
    Univ Adelaide, Adelaide, SA, Australia..
    Cirillo, Massimo
    Coates, Matthew M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Coggeshall, Megan
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Colistro, Valentina
    Colquhoun, Samantha M.
    Univ Melbourne, Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Cooper, Cyrus
    Univ Oxford, NIHR Musculoskeletal Biomed Res Ctr, Oxford, England..
    Cooper, Leslie Trumbull
    Cortinovis, Monica
    Dahiru, Tukur
    Damasceno, Albertino
    Danawi, Hadi
    Dandona, Rakhi
    Publ Hlth Fdn India, New Delhi, India..
    Das Neves, Jose
    De Leo, Diego
    Dellavalle, Robert P.
    Deribe, Kebede
    Deribew, Amare
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Jarlais, Don C. Des
    Dharmaratne, Samath D.
    Dicker, Daniel J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Ding, Eric L.
    Dossou, Edem
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Dubey, Manisha
    Ebel, Beth E.
    Univ Washington, Harborview Injury Prevent & Res Ctr, Seattle, WA USA..
    Ellingsen, Christian Lycke
    Elyazar, Iqbal
    Endries, Aman Yesuf
    Ermakov, Sergey Petrovich
    Eshrati, Babak
    Esteghamati, Alireza
    Faraon, Emerito Jose Aquino
    Univ Philippines, Coll Publ Hlth, Manila, Philippines.;Dept Hlth, Manila, Philippines..
    Farid, Talha A.
    Farinha, Carla Sofia E. Sa
    Faro, Andre
    Farvid, Maryam S.
    Farzadfar, Farshad
    Fereshtehnejad, Seyed-Mohammad
    Fernandes, Joao C.
    Fischer, Florian
    Univ Bielefeld, Bielefeld, Germany. Acad Med Sci, Inst Gerontol, Kiev, Ukraine..
    Fitchett, Joseph R. A.
    Fleming, Tom
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Gt, Nataliya Fo
    Franca, Elisabeth Barboza
    Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil..
    Franklin, Richard C.
    James Cook Univ, Townsville, Qld, Australia..
    Fraser, Maya S.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Friedman, Joseph
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Pullman, Nancy
    Furst, Thomas
    Univ Basel, Basel, Switzerland..
    Futran, Neal D.
    Univ Washington, Seattle, WA USA..
    Gambashidze, Ketevan
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Gamkrelidze, Amiran
    Gebre, Teshome
    Task Force Global Hlth, Decatur, GA USA..
    Gebrehiwot, Tsegaye Tewelde
    Gebremedhin, Amanuel Tesfay
    Ludwig Maximilians Univ Munchen, Munich, Germany..
    Gebremedhin, Mengistu
    Gebru, Alemseged Aregay
    Kilte Awlaelo Hlth & Demog Surveillance Syst, Mekelle, Ethiopia..
    Geleijnse, Johanna M.
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands..
    Gibney, Katherine B.
    Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia.;Royal Melbourne Hosp, Melbourne, Vic, Australia..
    Giref, Ababi Zergaw
    Giroud, Maurice
    Univ Hosp Dijon, Dijon, France..
    Gishu, Melkamu Dedefo
    Glaser, Elizabeth
    Goenka, Shifalika
    Publ Hlth Fdn India, New Delhi, India..
    Gomez-Dantes, Hector
    Gona, Philimon
    Goodridge, Amador
    Gopalani, Sameer Vali
    Goto, Atsushi
    Graetz, Nicholas
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Gugnani, Harish Chander
    Guo, Yuming
    Gupta, Rahul
    Gupta, Rajeev
    Gupta, Vipin
    Hafezi-Nejad, Nima
    Hailu, Alemayehu Desalegne
    Hailu, Gessessew Bugssa
    Kilte Awlaelo Hlth & Demog Surveillance Syst, Mekelle, Ethiopia..
    Hamadeh, Randah Ribhi
    Hamidi, Samer
    Hancock, Jamie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Handal, Alexis J.
    Hankey, Graeme J.
    Harb, Hilda L.
    Minist Publ Hlth, Beirut, Lebanon..
    Harikrishnan, Sivadasanpillai
    Harun, Kimani M.
    Univ Washington, Seattle, WA USA..
    Havmoeller, Rasmus
    Hoek, Hans W.
    Horino, Masako
    Horita, Nobuyuki
    Hosgood, H. Dean
    Hoy, Damian G.
    Htet, Aung Soe
    Hu, Guoqing
    Huang, Hsiang
    Huang, John J.
    Yale Univ, New Haven, CT USA..
    Huybrechts, Inge
    Huynh, Chantal
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Iannarone, Marissa
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Iburg, Kim Moesgaard
    Idrisov, Bulat T.
    Iyer, Veena J.
    Jacobsen, Kathryn H.
    Jahanmehr, Nader
    Jakovljevic, Mihajlo B.
    Javanbakht, Mehdi
    Jayatilleke, Achala Upendra
    Jee, Sun Ha
    Jeemon, Panniyammakal
    Publ Hlth Fdn India, Ctr Control Chron Condit, New Delhi, India..
    Jha, Vivekanand
    Univ Oxford, Oxford, England..
    Jiang, Guohong
    Jiang, Ying
    Jibat, Tariku
    Wageningen Univ, Wageningen, Netherlands..
    Jonas, Jost B.
    Kabir, Zubair
    Kamal, Ritul
    Kan, Haidong
    Karch, Andre
    Karletsos, Dimitris
    Kasaeian, Amir
    Kaul, Anil
    Kawakami, Norito
    Kayibanda, Jeanne Francoise
    Kazanjan, Konstantin
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Kazi, Dhruv S.
    Keiyoro, Peter Njenga
    Kemmer, Laura
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kemp, Andrew Haddon
    Univ Sydney, Sydney, NSW, Australia..
    Kengne, Andre Pascal
    Keren, Andre
    Kereselidze, Maia
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Kesavachandran, Chandrasekharan Nair
    Khader, Yousef Saleh
    Khan, Abdur Rahman
    Khan, Ejaz Ahmad
    Khang, Young-Ho
    Khonelidze, Irma
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Khosravi, Ardeshir
    Khubchandani, Jagdish
    Kim, Yun Jin
    Kivipelto, Miia
    Knibbs, Luke D.
    Kokubo, Yoshihiro
    Kosen, Soewarta
    Koul, Parvaiz A.
    Koyanagi, Ai
    Krishnaswami, Sanjay
    Defo, Barthelemy Kuate
    Bicer, Burcu Kucuk
    Kudom, Andreas A.
    Univ Cape Coast, Cape Coast, Ghana..
    Kulikoff, Xie Rachel
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kulkarni, Chanda
    Kumar, G. Anil
    Publ Hlth Fdn India, New Delhi, India..
    Kutz, Michael J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Lal, Dharmesh Kumar
    Lalloo, Ratilal
    Lam, Hilton
    Lamadrid-Figueroa, Hector
    Lan, Qing
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Laryea, Dennis Odai
    Leigh, James
    Univ Sydney, Sydney, NSW, Australia..
    Leung, Ricky
    Li, Yichong
    Li, Yongmei
    Lipshultz, Steven E.
    Liu, Patrick Y.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Liu, Shiwei
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Liu, Yang
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Lloyd, Belinda K.
    Lotufo, Paulo A.
    Lunevicius, Raimundas
    Ma, Stefan
    El Razek, Hassan Magdy Abd
    El Razek, Mohammed Magdy Abd
    Majdan, Marek
    Majeed, Azeem
    Malekzadeh, Reza
    Mapoma, Chabila C.
    Marcenes, Wagner
    Margolis, David Joel
    Marquez, Neal
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Masiye, Felix
    Marzan, Melvin Barrientos
    Mason-Jones, Amanda J.
    Mazorodze, Tasara T.
    Meaney, Peter A.
    Mehari, Alem
    Mehndiratta, Man Mohan
    Mena-Rodriguez, Fabiola
    Mekonnen, Alemayehu B.
    Univ Sydney, Sydney, NSW, Australia..
    Melaku, Yohannes Adama
    Univ Adelaide, Sch Med, Adelaide, SA, Australia..
    Memish, Ziad A.
    Mendoza, Walter
    Meretoja, Atte
    Univ Melbourne, Dept Med, Melbourne, Vic, Australia. Univ Melbourne, Inst Hlth & Ageing, Melbourne, Vic, Australia..
    Meretoja, Tuomo J.
    Mhimbira, Francis Apolinary
    Miller, Ted R.
    Mills, Edward J.
    Mirarefin, Mojde
    Misganaw, Awoke
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Ibrahim, Norlinah Mohamed
    Mohammad, Karzan Abdulmuhsin
    Mohammadi, Alireza
    Mohammed, Shafiu
    Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Mola, Glen Liddell D.
    Monasta, Lorenzo
    Monis, Jonathan De la Cruz
    Hernandez, Julio Cesar Montanez
    Montero, Pablo
    Montico, Marcella
    Mooney, Meghan D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Moore, Ami R.
    Moradi-Lakeh, Maziar
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Morawska, Lidia
    Mori, Rintaro
    Mueller, Ulrich
    Murthy, Gudlavalleti Venkata Satyanarayana
    London Sch Hyg & Trop Med, London, England..
    Murthy, Srinivas
    Nachega, Jean B.
    Naheed, Aliya
    Naldi, Luigi
    Nand, Devina
    Nangia, Vinay
    Nash, Denis
    Neupane, Subas
    Newton, John N.
    Ng, Marie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Ngalesoni, Frida Namnyak
    Nguhiu, Peter
    Nguyen, Grant
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Le Nguyen, Quyen
    Nisar, Muhammad Imran
    Aga Khan Univ, Karachi, Pakistan..
    Nomura, Marika
    Norheim, Ole F.
    Norman, Rosana E.
    Nyakarahuka, Luke
    Obermeyer, Carla Makhlouf
    Ogbo, Felix Akpojene
    Oh, In-Hwan
    Ojelabi, Foluke Adetola
    Univ Ibadan, Ibadan, Nigeria..
    Olivares, Pedro R.
    Olusanya, Bolajoko Olubukunola
    Olusanya, Jacob Olusegun
    Opio, John Nelson
    Oren, Eyal
    Ota, Erika
    Oyekale, Abayomi Samuel
    Pa, Mahesh
    Pain, Amanda
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Papantoniou, Nikolaos
    Park, Eun-Kee
    Park, Hye-Youn
    Caicedo, Angel J. Paternina
    Patten, Scott B.
    Paul, Vinod K.
    Pereira, David M.
    Perico, Norberto
    Pesudovs, Konrad
    Petzold, Max
    Phillips, Michael Robert
    Pillay, Julian David
    Pishgar, Farhad
    Polinder, Suzanne
    Pope, Daniel
    Pourmalek, Farshad
    Qorbani, Mostafa
    Rafay, Anwar
    Rahimi, Kazem
    Univ Oxford, Oxford, England..
    Rahimi-Movaghar, Vafa
    Rahman, Mahfuzar
    Rahman, Mohammad Hifz Ur
    Rahman, Sajjad Ur
    Rai, Rajesh Kumar
    Ram, Usha
    Ranabhat, Chhabi Lal
    Rangaswamy, Thara
    Rao, Paturi Vishnupriya
    Refaat, Amany H.
    Remuzzi, Giuseppe
    Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 20152016Inngår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 388, nr 10053, s. 1775-1812Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background In transitioning from the Millennium Development Goal to the Sustainable Development Goal era, it is imperative to comprehensively assess progress toward reducing maternal mortality to identify areas of success, remaining challenges, and frame policy discussions. We aimed to quantify maternal mortality throughout the world by underlying cause and age from 1990 to 2015. Methods We estimated maternal mortality at the global, regional, and national levels from 1990 to 2015 for ages 10-54 years by systematically compiling and processing all available data sources from 186 of 195 countries and territories, 11 of which were analysed at the subnational level. We quantified eight underlying causes of maternal death and four timing categories, improving estimation methods since GBD 2013 for adult all-cause mortality, HIV-related maternal mortality, and late maternal death. Secondary analyses then allowed systematic examination of drivers of trends, including the relation between maternal mortality and coverage of specific reproductive health-care services as well as assessment of observed versus expected maternal mortality as a function of Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Findings Only ten countries achieved MDG 5, but 122 of 195 countries have already met SDG 3.1. Geographical disparities widened between 1990 and 2015 and, in 2015, 24 countries still had a maternal mortality ratio greater than 400. The proportion of all maternal deaths occurring in the bottom two SDI quintiles, where haemorrhage is the dominant cause of maternal death, increased from roughly 68% in 1990 to more than 80% in 2015. The middle SDI quintile improved the most from 1990 to 2015, but also has the most complicated causal profile. Maternal mortality in the highest SDI quintile is mostly due to other direct maternal disorders, indirect maternal disorders, and abortion, ectopic pregnancy, and/or miscarriage. Historical patterns suggest achievement of SDG 3.1 will require 91% coverage of one antenatal care visit, 78% of four antenatal care visits, 81% of in-facility delivery, and 87% of skilled birth attendance. Interpretation Several challenges to improving reproductive health lie ahead in the SDG era. Countries should establish or renew systems for collection and timely dissemination of health data; expand coverage and improve quality of family planning services, including access to contraception and safe abortion to address high adolescent fertility; invest in improving health system capacity, including coverage of routine reproductive health care and of more advanced obstetric care-including EmOC; adapt health systems and data collection systems to monitor and reverse the increase in indirect, other direct, and late maternal deaths, especially in high SDI locations; and examine their own performance with respect to their SDI level, using that information to formulate strategies to improve performance and ensure optimum reproductive health of their population.

  • 107. Kassebaum, Nicholas J
    et al.
    Bertozzi-Villa, Amelia
    Coggeshall, Megan S
    Shackelford, Katya A
    Steiner, Caitlyn
    Heuton, Kyle R
    Gonzalez-Medina, Diego
    Barber, Ryan
    Huynh, Chantal
    Dicker, Daniel
    Templin, Tara
    Wolock, Timothy M
    Ozgoren, Ayse Abbasoglu
    Abd-Allah, Foad
    Abera, Semaw Ferede
    Achoki, Tom
    Adelekan, Ademola
    Ademi, Zanfina
    Adou, Arsène Kouablan
    Adsuar, José C
    Agardh, Emilie E
    Akena, Dickens
    Alasfoor, Deena
    Alemu, Zewdie Aderaw
    Alfonso-Cristancho, Rafael
    Alhabib, Samia
    Ali, Raghib
    Al Kahbouri, Mazin J
    Alla, François
    Allen, Peter J
    Almazroa, Mohammad A
    Alsharif, Ubai
    Alvarez, Elena
    Alvis-Guzmán, Nelson
    Amankwaa, Adansi A
    Amare, Azmeraw T
    Amini, Hassan
    Ammar, Walid
    Antonio, Carl A T
    Anwari, Palwasha
    Ärnlöv, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi.
    Arsenijevic, Valentina S Arsic
    Artaman, Ali
    Asad, Majed Masoud
    Asghar, Rana J
    Assadi, Reza
    Atkins, Lydia S
    Badawi, Alaa
    Balakrishnan, Kalpana
    Basu, Arindam
    Basu, Sanjay
    Beardsley, Justin
    Bedi, Neeraj
    Bekele, Tolesa
    Bell, Michelle L
    Bernabe, Eduardo
    Beyene, Tariku J
    Bhutta, Zulfiqar
    Bin Abdulhak, Aref
    Blore, Jed
    Basara, Berrak Bora
    Bose, Dipan
    Breitborde, Nicholas
    Cárdenas, Rosario
    Castañeda-Orjuela, Carlos A
    Castro, Ruben Estanislao
    Catalá-López, Ferrán
    Cavlin, Alanur
    Chang, Jung-Chen
    Che, Xuan
    Christophi, Costas A
    Chugh, Sumeet S
    Cirillo, Massimo
    Colquhoun, Samantha M
    Cooper, Leslie Trumbull
    Cooper, Cyrus
    da Costa Leite, Iuri
    Dandona, Lalit
    Dandona, Rakhi
    Davis, Adrian
    Dayama, Anand
    Degenhardt, Louisa
    De Leo, Diego
    Del Pozo-Cruz, Borja
    Deribe, Kebede
    Dessalegn, Muluken
    Deveber, Gabrielle A
    Dharmaratne, Samath D
    Dilmen, Uğur
    Ding, Eric L
    Dorrington, Rob E
    Driscoll, Tim R
    Ermakov, Sergei Petrovich
    Esteghamati, Alireza
    Faraon, Emerito Jose A
    Farzadfar, Farshad
    Felicio, Manuela Mendonca
    Fereshtehnejad, Seyed-Mohammad
    de Lima, Graça Maria Ferreira
    Forouzanfar, Mohammad H
    França, Elisabeth B
    Gaffikin, Lynne
    Gambashidze, Ketevan
    Gankpé, Fortuné Gbètoho
    Garcia, Ana C
    Geleijnse, Johanna M
    Gibney, Katherine B
    Giroud, Maurice
    Glaser, Elizabeth L
    Goginashvili, Ketevan
    Gona, Philimon
    González-Castell, Dinorah
    Goto, Atsushi
    Gouda, Hebe N
    Gugnani, Harish Chander
    Gupta, Rahul
    Gupta, Rajeev
    Hafezi-Nejad, Nima
    Hamadeh, Randah Ribhi
    Hammami, Mouhanad
    Hankey, Graeme J
    Harb, Hilda L
    Havmoeller, Rasmus
    Hay, Simon
    Pi, Ileana B Heredia
    Hoek, Hans W
    Hosgood, H Dean
    Hoy, Damian G
    Husseini, Abdullatif
    Idrisov, Bulat T
    Innos, Kaire
    Inoue, Manami
    Jacobsen, Kathryn H
    Jahangir, Eiman
    Jee, Sun Ha
    Jensen, Paul N
    Jha, Vivekanand
    Jiang, Guohong
    Juel, Knud
    Kabagambe, Edmond Kato
    Kan, Haidong
    Karam, Nadim E
    Karch, André
    Karema, Corine Kakizi
    Kaul, Anil
    Kawakami, Norito
    Kazanjan, Konstantin
    Kazi, Dhruv S
    Kemp, Andrew G
    Kengne, Andre Pascal
    Kereselidze, Maia
    Khader, Yousef Saleh
    Khalifa, Shams Eldin Ali Hassan
    Khan, Ejaz Ahmed
    Khang, Young-Ho
    Knibbs, Luke
    Kokubo, Yoshihiro
    Kosen, Soewarta
    Defo, Barthelemy Kuate
    Kulkarni, Chanda
    Kulkarni, Veena S
    Kumar, G Anil
    Kumar, Kaushalendra
    Kumar, Ravi B
    Kwan, Gene
    Lai, Taavi
    Lalloo, Ratilal
    Lam, Hilton
    Lansingh, Van C
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Lee, Jong-Tae
    Leigh, James
    Leinsalu, Mall
    Leung, Ricky
    Li, Xiaohong
    Li, Yichong
    Li, Yongmei
    Liang, Juan
    Liang, Xiaofeng
    Lim, Stephen S
    Lin, Hsien-Ho
    Lipshultz, Steven E
    Liu, Shiwei
    Liu, Yang
    Lloyd, Belinda K
    London, Stephanie J
    Lotufo, Paulo A
    Ma, Jixiang
    Ma, Stefan
    Machado, Vasco Manuel Pedro
    Mainoo, Nana Kwaku
    Majdan, Marek
    Mapoma, Christopher Chabila
    Marcenes, Wagner
    Marzan, Melvin Barrientos
    Mason-Jones, Amanda J
    Mehndiratta, Man Mohan
    Mejia-Rodriguez, Fabiola
    Memish, Ziad A
    Mendoza, Walter
    Miller, Ted R
    Mills, Edward J
    Mokdad, Ali H
    Mola, Glen Liddell
    Monasta, Lorenzo
    de la Cruz Monis, Jonathan
    Hernandez, Julio Cesar Montañez
    Moore, Ami R
    Mori, Rintaro
    Mueller, Ulrich O
    Mukaigawara, Mitsuru
    Naheed, Aliya
    Naidoo, Kovin S
    Nand, Devina
    Nangia, Vinay
    Nash, Denis
    Nejjari, Chakib
    Nelson, Robert G
    Neupane, Sudan Prasad
    Newton, Charles R
    Ng, Marie
    Nieuwenhuijsen, Mark J
    Nisar, Muhammad Imran
    Nolte, Sandra
    Norheim, Ole F
    Nyakarahuka, Luke
    Oh, In-Hwan
    Ohkubo, Takayoshi
    Olusanya, Bolajoko O
    Omer, Saad B
    Opio, John Nelson
    Orisakwe, Orish Ebere
    Pandian, Jeyaraj D
    Papachristou, Christina
    Park, Jae-Hyun
    Caicedo, Angel J Paternina
    Patten, Scott B
    Paul, Vinod K
    Pavlin, Boris Igor
    Pearce, Neil
    Pereira, David M
    Pesudovs, Konrad
    Petzold, Max
    Poenaru, Dan
    Polanczyk, Guilherme V
    Polinder, Suzanne
    Pope, Dan
    Pourmalek, Farshad
    Qato, Dima
    Quistberg, D Alex
    Rafay, Anwar
    Rahimi, Kazem
    Rahimi-Movaghar, Vafa
    Ur Rahman, Sajjad
    Raju, Murugesan
    Rana, Saleem M
    Refaat, Amany
    Ronfani, Luca
    Roy, Nobhojit
    Pimienta, Tania Georgina Sánchez
    Sahraian, Mohammad Ali
    Salomon, Joshua
    Sampson, Uchechukwu
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    Shibuya, Kenji
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    Tan, Feng
    Teixeira, Carolina Maria
    Tenkorang, Eric Yeboah
    Terkawi, Abdullah Sulieman
    Thorne-Lyman, Andrew L
    Tirschwell, David L
    Towbin, Jeffrey A
    Tran, Bach X
    Tsilimbaris, Miltiadis
    Uchendu, Uche S
    Ukwaja, Kingsley N
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    Uzun, Selen Begüm
    Vallely, Andrew J
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    Venketasubramanian, N
    Villalpando, Salvador
    Violante, Francesco S
    Vlassov, Vasiliy Victorovich
    Vos, Theo
    Waller, Stephen
    Wang, Haidong
    Wang, Linhong
    Wang, Sharon Xiaorong
    Wang, Yanping
    Weichenthal, Scott
    Weiderpass, Elisabete
    Weintraub, Robert G
    Westerman, Ronny
    Wilkinson, James D
    Woldeyohannes, Solomon Meseret
    Wong, John Q
    Wordofa, Muluemebet Abera
    Xu, Gelin
    Yang, Yang C
    Yano, Yuichiro
    Yentur, Gokalp Kadri
    Yip, Paul
    Yonemoto, Naohiro
    Yoon, Seok-Jun
    Younis, Mustafa Z
    Yu, Chuanhua
    Jin, Kim Yun
    El Sayed Zaki, Maysaa
    Zhao, Yong
    Zheng, Yingfeng
    Zhou, Maigeng
    Zhu, Jun
    Zou, Xiao Nong
    Lopez, Alan D
    Naghavi, Mohsen
    Murray, Christopher J L
    Lozano, Rafael
    Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 20132014Inngår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 384, nr 9947, s. 980-1004Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100 000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery.

    METHODS: We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to analyse a database of data for 7065 site-years and estimate the number of maternal deaths from all causes in 188 countries between 1990 and 2013. We estimated the number of pregnancy-related deaths caused by HIV on the basis of a systematic review of the relative risk of dying during pregnancy for HIV-positive women compared with HIV-negative women. We also estimated the fraction of these deaths aggravated by pregnancy on the basis of a systematic review. To estimate the numbers of maternal deaths due to nine different causes, we identified 61 sources from a systematic review and 943 site-years of vital registration data. We also did a systematic review of reports about the timing of maternal death, identifying 142 sources to use in our analysis. We developed estimates for each country for 1990-2013 using Bayesian meta-regression. We estimated 95% uncertainty intervals (UIs) for all values.

    FINDINGS: 292 982 (95% UI 261 017-327 792) maternal deaths occurred in 2013, compared with 376 034 (343 483-407 574) in 1990. The global annual rate of change in the MMR was -0·3% (-1·1 to 0·6) from 1990 to 2003, and -2·7% (-3·9 to -1·5) from 2003 to 2013, with evidence of continued acceleration. MMRs reduced consistently in south, east, and southeast Asia between 1990 and 2013, but maternal deaths increased in much of sub-Saharan Africa during the 1990s. 2070 (1290-2866) maternal deaths were related to HIV in 2013, 0·4% (0·2-0·6) of the global total. MMR was highest in the oldest age groups in both 1990 and 2013. In 2013, most deaths occurred intrapartum or postpartum. Causes varied by region and between 1990 and 2013. We recorded substantial variation in the MMR by country in 2013, from 956·8 (685·1-1262·8) in South Sudan to 2·4 (1·6-3·6) in Iceland.

    INTERPRETATION: Global rates of change suggest that only 16 countries will achieve the MDG 5 target by 2015. Accelerated reductions since the Millennium Declaration in 2000 coincide with increased development assistance for maternal, newborn, and child health. Setting of targets and associated interventions for after 2015 will need careful consideration of regions that are making slow progress, such as west and central Africa.

  • 108. Kassebaum, Nicholas
    et al.
    Kyu, Hmwe Hmwe
    Zoeckler, Leo
    Olsen, Helen Elizabeth
    Thomas, Katie
    Pinho, Christine
    Bhutta, Zulfiqar A
    Dandona, Lalit
    Ferrari, Alize
    Ghiwot, Tsegaye Tewelde
    Hay, Simon I
    Kinfu, Yohannes
    Liang, Xiaofeng
    Lopez, Alan
    Malta, Deborah Carvalho
    Mokdad, Ali H
    Naghavi, Mohsen
    Patton, George C
    Salomon, Joshua
    Sartorius, Benn
    Topor-Madry, Roman
    Vollset, Stein Emil
    Werdecker, Andrea
    Whiteford, Harvey A
    Abate, Kalkidan Hasen
    Abbas, Kaja
    Abreha Damtew, Solomon
    Ahmed, Muktar Beshir
    Akseer, Nadia
    Al-Raddadi, Rajaa
    Alemayohu, Mulubirhan Assefa
    Altirkawi, Khalid
    Abajobir, Amanuel Alemu
    Amare, Azmeraw T
    Antonio, Carl A T
    Ärnlöv, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Artaman, Al
    Asayesh, Hamid
    Avokpaho, Euripide Frinel G Arthur
    Awasthi, Ashish
    Ayala Quintanilla, Beatriz Paulina
    Bacha, Umar
    Balem, Dimtsu
    Barac, Aleksandra
    Bärnighausen, Till Winfried
    Baye, Estifanos
    Bedi, Neeraj
    Bensenor, Isabela M
    Berhane, Adugnaw
    Bernabe, Eduardo
    Bernal, Oscar Alberto
    Beyene, Addisu Shunu
    Biadgilign, Sibhatu
    Bikbov, Boris
    Boyce, Cheryl Anne
    Brazinova, Alexandra
    Hailu, Gessessew Bugssa
    Carter, Austin
    Castañeda-Orjuela, Carlos A
    Catalá-López, Ferrán
    Charlson, Fiona J
    Chitheer, Abdulaal A
    Choi, Jee-Young Jasmine
    Ciobanu, Liliana G
    Crump, John
    Dandona, Rakhi
    Dellavalle, Robert P
    Deribew, Amare
    deVeber, Gabrielle
    Dicker, Daniel
    Betsu, Balem Balm
    Ding, Eric L
    Dubey, Manisha
    Endries, Amanuel Yesuf
    Erskine, Holly E
    Faraon, Emerito Jose Aquino
    Faro, Andre
    Farzadfar, Farshad
    Fernandes, Joao C
    Fijabi, Daniel Obadare
    Fitzmaurice, Christina
    Fleming, Thomas D
    Flor, Luisa Sorio
    Foreman, Kyle J
    Franklin, Richard C
    Fraser, Maya S
    Frostad, Joseph J
    Fullman, Nancy
    Gebregergs, Gebremedhin Berhe
    Gebru, Alemseged Aregay
    Geleijnse, Johanna M
    Gibney, Katherine B
    Gidey Yihdego, Mahari
    Ginawi, Ibrahim Abdelmageem Mohamed
    Gishu, Melkamu Dedefo
    Gizachew, Tessema Assefa
    Glaser, Elizabeth
    Gold, Audra L
    Goldberg, Ellen
    Gona, Philimon
    Goto, Atsushi
    Gugnani, Harish Chander
    Jiang, Guohong
    Gupta, Rajeev
    Tesfay, Fisaha Haile
    Hankey, Graeme J
    Havmoeller, Rasmus
    Hijar, Martha
    Horino, Masako
    Hosgood, H Dean
    Hu, Guoqing
    Jacobsen, Kathryn H
    Jakovljevic, Mihajlo B
    Jayaraman, Sudha P
    Jha, Vivekanand
    Jibat, Tariku
    Johnson, Catherine O
    Jonas, Jost
    Kasaeian, Amir
    Kawakami, Norito
    Keiyoro, Peter N
    Khalil, Ibrahim
    Khang, Young-Ho
    Khubchandani, Jagdish
    Ahmad Kiadaliri, Aliasghar A
    Kieling, Christian
    Kim, Daniel
    Kissoon, Niranjan
    Knibbs, Luke D
    Koyanagi, Ai
    Krohn, Kristopher J
    Kuate Defo, Barthelemy
    Kucuk Bicer, Burcu
    Kulikoff, Rachel
    Kumar, G Anil
    Lal, Dharmesh Kumar
    Lam, Hilton Y
    Larson, Heidi J
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Laryea, Dennis Odai
    Leung, Janni
    Lim, Stephen S
    Lo, Loon-Tzian
    Lo, Warren D
    Looker, Katharine J
    Lotufo, Paulo A
    Magdy Abd, Hassan
    El Razek, Razek
    Malekzadeh, Reza
    Markos Shifti, Desalegn
    Mazidi, Mohsen
    Meaney, Peter A
    Meles, Kidanu Gebremariam
    Memiah, Peter
    Mendoza, Walter
    Abera Mengistie, Mubarek
    Mengistu, Gebremichael Welday
    Mensah, George A
    Miller, Ted R
    Mock, Charles
    Mohammadi, Alireza
    Mohammed, Shafiu
    Monasta, Lorenzo
    Mueller, Ulrich
    Nagata, Chie
    Naheed, Aliya
    Nguyen, Grant
    Nguyen, Quyen Le
    Nsoesie, Elaine
    Oh, In-Hwan
    Okoro, Anselm
    Olusanya, Jacob Olusegun
    Olusanya, Bolajoko O
    Ortiz, Alberto
    Paudel, Deepak
    Pereira, David M
    Perico, Norberto
    Petzold, Max
    Phillips, Michael Robert
    Polanczyk, Guilherme V
    Pourmalek, Farshad
    Qorbani, Mostafa
    Rafay, Anwar
    Rahimi-Movaghar, Vafa
    Rahman, Mahfuzar
    Rai, Rajesh Kumar
    Ram, Usha
    Rankin, Zane
    Remuzzi, Giuseppe
    Renzaho, Andre M N
    Roba, Hirbo Shore
    Rojas-Rueda, David
    Ronfani, Luca
    Sagar, Rajesh
    Sanabria, Juan Ramon
    Kedir Mohammed, Muktar Sano
    Santos, Itamar S
    Satpathy, Maheswar
    Sawhney, Monika
    Schöttker, Ben
    Schwebel, David C
    Scott, James G
    Sepanlou, Sadaf G
    Shaheen, Amira
    Shaikh, Masood Ali
    She, June
    Shiri, Rahman
    Shiue, Ivy
    Sigfusdottir, Inga Dora
    Singh, Jasvinder
    Slipakit, Naris
    Smith, Alison
    Sreeramareddy, Chandrashekhar
    Stanaway, Jeffrey D
    Stein, Dan J
    Steiner, Caitlyn
    Sufiyan, Muawiyyah Babale
    Swaminathan, Soumya
    Tabarés-Seisdedos, Rafael
    Tabb, Karen M
    Tadese, Fentaw
    Tavakkoli, Mohammad
    Taye, Bineyam
    Teeple, Stephanie
    Tegegne, Teketo Kassaw
    Temam Shifa, Girma
    Terkawi, Adbullah Sulieman
    Thomas, Bernadette
    Thomson, Alan J
    Tobe-Gai, Ruoyan
    Tonelli, Marcello
    Tran, Bach Xuan
    Troeger, Christopher
    Ukwaja, Kingsley N
    Uthman, Olalekan
    Vasankari, Tommi
    Venketasubramanian, Narayanaswamy
    Vlassov, Vasiliy Victorovich
    Weiderpass, Elisabete
    Weintraub, Robert
    Gebrehiwot, Solomon Weldemariam
    Westerman, Ronny
    Williams, Hywel C
    Wolfe, Charles D A
    Woodbrook, Rachel
    Yano, Yuichiro
    Yonemoto, Naohiro
    Yoon, Seok-Jun
    Younis, Mustafa Z
    Yu, Chuanhua
    Zaki, Maysaa El Sayed
    Zegeye, Elias Asfaw
    Zuhlke, Liesl Joanna
    Murray, Christopher J L
    Vos, Theo
    Child and Adolescent Health From 1990 to 2015: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2015 Study2017Inngår i: JAMA pediatrics, ISSN 2168-6203, E-ISSN 2168-6211, Vol. 171, nr 6, s. 573-592Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Importance: Comprehensive and timely monitoring of disease burden in all age groups, including children and adolescents, is essential for improving population health.

    Objective: To quantify and describe levels and trends of mortality and nonfatal health outcomes among children and adolescents from 1990 to 2015 to provide a framework for policy discussion.

    Evidence Review: Cause-specific mortality and nonfatal health outcomes were analyzed for 195 countries and territories by age group, sex, and year from 1990 to 2015 using standardized approaches for data processing and statistical modeling, with subsequent analysis of the findings to describe levels and trends across geography and time among children and adolescents 19 years or younger. A composite indicator of income, education, and fertility was developed (Socio-demographic Index [SDI]) for each geographic unit and year, which evaluates the historical association between SDI and health loss.

    Findings: Global child and adolescent mortality decreased from 14.18 million (95% uncertainty interval [UI], 14.09 million to 14.28 million) deaths in 1990 to 7.26 million (95% UI, 7.14 million to 7.39 million) deaths in 2015, but progress has been unevenly distributed. Countries with a lower SDI had a larger proportion of mortality burden (75%) in 2015 than was the case in 1990 (61%). Most deaths in 2015 occurred in South Asia and sub-Saharan Africa. Global trends were driven by reductions in mortality owing to infectious, nutritional, and neonatal disorders, which in the aggregate led to a relative increase in the importance of noncommunicable diseases and injuries in explaining global disease burden. The absolute burden of disability in children and adolescents increased 4.3% (95% UI, 3.1%-5.6%) from 1990 to 2015, with much of the increase owing to population growth and improved survival for children and adolescents to older ages. Other than infectious conditions, many top causes of disability are associated with long-term sequelae of conditions present at birth (eg, neonatal disorders, congenital birth defects, and hemoglobinopathies) and complications of a variety of infections and nutritional deficiencies. Anemia, developmental intellectual disability, hearing loss, epilepsy, and vision loss are important contributors to childhood disability that can arise from multiple causes. Maternal and reproductive health remains a key cause of disease burden in adolescent females, especially in lower-SDI countries. In low-SDI countries, mortality is the primary driver of health loss for children and adolescents, whereas disability predominates in higher-SDI locations; the specific pattern of epidemiological transition varies across diseases and injuries.

    Conclusions and Relevance: Consistent international attention and investment have led to sustained improvements in causes of health loss among children and adolescents in many countries, although progress has been uneven. The persistence of infectious diseases in some countries, coupled with ongoing epidemiologic transition to injuries and noncommunicable diseases, require all countries to carefully evaluate and implement appropriate strategies to maximize the health of their children and adolescents and for the international community to carefully consider which elements of child and adolescent health should be monitored.

  • 109.
    Katja, Junus
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Obstetrik & gynekologi.
    Anna-Karin, Wikström
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Obstetrik & gynekologi.
    Anders, Larsson
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Olovsson, Matts
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Obstetrik & gynekologi.
    PP015. Plasma levels and placental expression of BNP/NT-proBNP in early and late onset preeclampsia2013Inngår i: Pregnancy Hypertension, ISSN 2210-7789, E-ISSN 2210-7797, Vol. 3, nr 2, s. 73-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    INTRODUCTION:

    Women with preeclampsia (PE) have elevated plasma levels of NT-proBNP. We hypothesized that the placenta may be a source to these elevated levels.

    OBJECTIVES:

    Our objectives were to study the plasma levels of NT-proBNP and the protein and mRNA expression of placental BNP in women with early and late onset PE and controls.

    METHODS:

    Plasma levels of NT-proBNP were measured in women with early (n=18) and late (n=20) onset PE, in two groups of healthy pregnant women in gestational week 24-32 (n=22) and 36-42 (n=14), and in non-pregnant women (n=20). Placental BNP protein and mRNA was studied with immunohistochemistry and qPCR. Placental release of NT-proBNP was studied with tissue culturing.

    RESULTS:

    Women with early (365 (14-9815) pg/ml) and late (176 (33-2547) pg/ml) onset PE had higher levels of NT-proBNP in plasma than their respective controls (p<0.001). A tendency towards higher plasma levels in early compared to late onset PE was observed (p=0.057). 20 out of 25 placental tissue samples had proBNP mRNA, no differences between the study groups were found. BNP protein was found in maternal spiral arteries and syncytiotrophoblasts. NT-proBNP peptide (6-7pg/ml) was present in medium used for placenta cultures.

    CONCLUSIONS:

    Our results suggest that there may be a placental source of NT-proBNP. If this source is responsible for the elevated plasma levels of NT-proBNP in preeclamptic women and what role, if any, BNP/NT-proBNP play in PE pathophysiology remains to be elucidated.

  • 110.
    Khezri, Banafsheh
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Helmersson-Karlqvist, Johanna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Estimation of the possible economic effects of a sequential testing strategy with NT-proBNP before echocardiography in primary care2014Inngår i: Clinical Laboratory, ISSN 1433-6510, Vol. 60, nr 7-8, s. 881-886Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND:

    The object of the study was to estimate the possible economic effects of a sequential testing strategy with NT-proBNP from a primary care payer perspective.

    METHODS:

    The study data were collected from primary care physicians in the County of Uppland from 2005 through 2012. Two different cut-off levels were used for negative NT-proBNP in the rule-out test: 300 and 400 pg/mL. The cost-effectiveness of the testing strategy was estimated through the short-term cost avoidance and reduction in demand for echocardiographies.

    RESULTS:

    The female patients were slightly older than the males. Based on the data from 2012, the estimated costs for NT-proBNP tests and echocardiographies per county were reduced by EUR 300000/100000 inhabitants with the 300 pg/mL cut-off and EUR 350000/100000 inhabitants with the 400 pg/mL.

    CONCLUSIONS:

    The use of NT-proBNP as a rule-out test in a sequential testing strategy reduced the cost for diagnostic work-up of primary care patients with suspected heart failure.

  • 111.
    Khezri, Banafsheh Seyyed
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Carlsson, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Evaluation of the Alere NT-proBNP Test for Point of Care Testing2016Inngår i: Journal of clinical laboratory analysis (Print), ISSN 0887-8013, E-ISSN 1098-2825, Vol. 30, nr 4, s. 290-292Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The object of the study was to evaluate the Alere point of care NT-proBNP assay as a suitable alternative to the central laboratory method to provide short test turnaround times in primary care.

    METHOD: Blood NT-proBNP results obtained with the Alere assay (n = 100) were compared with serum NT-proBNP results analyzed by a Cobas 8000 analyzer (Roche Diagnostics, Mannheim, Germany).

    RESULTS: There was a good agreement between the two NT-proBNP methods when used as a rule-out test for heart failure (HF) and the cut-off value <300 ng/l. A total of 47 samples gave values <300 ng/L with both methods and 51 samples gave values >300 with both methods. Thus, there was an agreement for 98% of the samples.

    CONCLUSIONS: The study shows that the Alere NT-proBNP assay could be used in primary care permitting rapid NT-proBNP testing to rule out HF.

  • 112. Kyu, Hmwe H
    et al.
    Pinho, Christine
    Wagner, Joseph A
    Brown, Jonathan C
    Bertozzi-Villa, Amelia
    Charlson, Fiona J
    Coffeng, Luc Edgar
    Dandona, Lalit
    Erskine, Holly E
    Ferrari, Alize J
    Fitzmaurice, Christina
    Fleming, Thomas D
    Forouzanfar, Mohammad H
    Graetz, Nicholas
    Guinovart, Caterina
    Haagsma, Juanita
    Higashi, Hideki
    Kassebaum, Nicholas J
    Larson, Heidi J
    Lim, Stephen S
    Mokdad, Ali H
    Moradi-Lakeh, Maziar
    Odell, Shaun V
    Roth, Gregory A
    Serina, Peter T
    Stanaway, Jeffrey D
    Misganaw, Awoke
    Whiteford, Harvey A
    Wolock, Timothy M
    Wulf Hanson, Sarah
    Abd-Allah, Foad
    Abera, Semaw Ferede
    Abu-Raddad, Laith J
    AlBuhairan, Fadia S
    Amare, Azmeraw T
    Antonio, Carl Abelardo T
    Artaman, Al
    Barker-Collo, Suzanne L
    Barrero, Lope H
    Benjet, Corina
    Bensenor, Isabela M
    Bhutta, Zulfiqar A
    Bikbov, Boris
    Brazinova, Alexandra
    Campos-Nonato, Ismael
    Castañeda-Orjuela, Carlos A
    Catalá-López, Ferrán
    Chowdhury, Rajiv
    Cooper, Cyrus
    Crump, John A
    Dandona, Rakhi
    Degenhardt, Louisa
    Dellavalle, Robert P
    Dharmaratne, Samath D
    Faraon, Emerito Jose A
    Feigin, Valery L
    Fürst, Thomas
    Geleijnse, Johanna M
    Gessner, Bradford D
    Gibney, Katherine B
    Goto, Atsushi
    Gunnell, David
    Hankey, Graeme J
    Hay, Roderick J
    Hornberger, John C
    Hosgood, H Dean
    Hu, Guoqing
    Jacobsen, Kathryn H
    Jayaraman, Sudha P
    Jeemon, Panniyammakal
    Jonas, Jost B
    Karch, André
    Kim, Daniel
    Kim, Sungroul
    Kokubo, Yoshihiro
    Kuate Defo, Barthelemy
    Kucuk Bicer, Burcu
    Kumar, G Anil
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Leasher, Janet L
    Leung, Ricky
    Li, Yongmei
    Lipshultz, Steven E
    Lopez, Alan D
    Lotufo, Paulo A
    Lunevicius, Raimundas
    Lyons, Ronan A
    Majdan, Marek
    Malekzadeh, Reza
    Mashal, Taufiq
    Mason-Jones, Amanda J
    Melaku, Yohannes Adama
    Memish, Ziad A
    Mendoza, Walter
    Miller, Ted R
    Mock, Charles N
    Murray, Joseph
    Nolte, Sandra
    Oh, In-Hwan
    Olusanya, Bolajoko Olubukunola
    Ortblad, Katrina F
    Park, Eun-Kee
    Paternina Caicedo, Angel J
    Patten, Scott B
    Patton, George C
    Pereira, David M
    Perico, Norberto
    Piel, Frédéric B
    Polinder, Suzanne
    Popova, Svetlana
    Pourmalek, Farshad
    Quistberg, D Alex
    Remuzzi, Giuseppe
    Rodriguez, Alina
    Rojas-Rueda, David
    Rothenbacher, Dietrich
    Rothstein, David H
    Sanabria, Juan
    Santos, Itamar S
    Schwebel, David C
    Sepanlou, Sadaf G
    Shaheen, Amira
    Shiri, Rahman
    Shiue, Ivy
    Skirbekk, Vegard
    Sliwa, Karen
    Sreeramareddy, Chandrashekhar T
    Stein, Dan J
    Steiner, Timothy J
    Stovner, Lars Jacob
    Sykes, Bryan L
    Tabb, Karen M
    Terkawi, Abdullah Sulieman
    Thomson, Alan J
    Thorne-Lyman, Andrew L
    Towbin, Jeffrey Allen
    Ukwaja, Kingsley Nnanna
    Vasankari, Tommi
    Venketasubramanian, Narayanaswamy
    Vlassov, Vasiliy Victorovich
    Vollset, Stein Emil
    Weiderpass, Elisabete
    Weintraub, Robert G
    Werdecker, Andrea
    Wilkinson, James D
    Woldeyohannes, Solomon Meseret
    Wolfe, Charles D A
    Yano, Yuichiro
    Yip, Paul
    Yonemoto, Naohiro
    Yoon, Seok-Jun
    Younis, Mustafa Z
    Yu, Chuanhua
    El Sayed Zaki, Maysaa
    Naghavi, Mohsen
    Murray, Christopher J L
    Vos, Theo
    Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study2016Inngår i: JAMA pediatrics, ISSN 2168-6203, E-ISSN 2168-6211, Vol. 170, nr 3, s. 267-287Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Importance: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce.

    Objective: To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study.

    Evidence Review: Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14 244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35 620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates.

    Findings: Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905 059 deaths; 95% UI, 810 304-998 125), diarrheal diseases among older children (38 325 deaths; 95% UI, 30 365-47 678), and road injuries among adolescents (115 186 deaths; 95% UI, 105 185-124 870). Iron deficiency anemia was the leading cause of years lived with disability among children and adolescents, affecting 619 (95% UI, 618-621) million in 2013. Large between-country variations exist in mortality from leading causes among children and adolescents. Countries with rapid declines in all-cause mortality between 1990 and 2013 also experienced large declines in most leading causes of death, whereas countries with the slowest declines had stagnant or increasing trends in the leading causes of death. In 2013, Nigeria had a 12% global share of deaths from lower respiratory tract infections and a 38% global share of deaths from malaria. India had 33% of the world's deaths from neonatal encephalopathy. Half of the world's diarrheal deaths among children and adolescents occurred in just 5 countries: India, Democratic Republic of the Congo, Pakistan, Nigeria, and Ethiopia.

    Conclusions and Relevance: Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.

  • 113.
    Lannergård, Anders
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Infektionssjukdomar.
    Friman, Göran
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Infektionssjukdomar.
    Ewald, Uwe
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk kemi.
    Serum amyloid A (SAA) protein and high-sensitivity C-reactive protein (hsCRP) in healthy newborn infants and healthy young through elderly adults2005Inngår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 94, nr 9, s. 1198-1202Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    AIM:

    To determine the levels of serum amyloid A (SAA) protein and high-sensitivity C-reactive protein (hsCRP) in different age groups.

    METHODS:

    Serum samples from 70 healthy newborn infants, 80 blood donors and 81 healthy elderly individuals were analysed using a nephelometric method. The 231 samples were grouped as follows: 35 umbilical cords, 35 newborns, 48 young adults, 28 middle-aged adults, and 85 elderly adults.

    RESULTS:

    Serum levels of both SAA and hsCRP were lower in umbilical cords than in the newborns and young, middle-aged and elderly adults (p<0.0001). The SAA and hsCRP levels were comparable in newborns, and young and middle-age adults, but higher in elderly adults (p<0.0001-0.03). SAA (r2=0.159, p<0.0001) and hsCRP (r2=0.059, p<0.0001) were positively correlated with age and to each other (r2=0.385, p<0.0001).

    CONCLUSION:

    Serum levels of SAA and hsCRP in umbilical cord blood are close to the detection limit and lower than in the other age groups investigated. The elderly have generally higher levels than the younger age groups, which require higher decision levels in inflammatory diseases, including infections. In newborns and young and middle-aged adults, the lower decision levels of 10 mg/l for SAA and 5 mg/l for CRP are suggested.

  • 114. Larssen, Pia
    et al.
    Wik, Lotta
    Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Czarnewski, Paulo
    Eldh, Maria
    Löf, Liza
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    Ronquist, Göran
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Dubois, Louise
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Freyhult, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Cancerfarmakologi och beräkningsmedicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Gallant, Caroline
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    Oelrich, Johan
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Ronquist, Gunnar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Villablanca, Eduardo
    Landegren, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Gabrielsson, Susanne
    Kamali-Moghaddam, Masood
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assay2017Inngår i: Molecular & cellular proteomics (online), ISSN 1535-9476, E-ISSN 1535-9484, Vol. 16, nr 3, s. 502-511Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Extracellular vesicles (EVs) are membrane-coated objects such as exosomes and microvesicles, released by many cell-types. Their presence in body fluids and the variable surface composition and content render them attractive potential biomarkers. The ability to determine their cellular origin could greatly move the field forward. We used multiplex proximity extension assays (PEA) to identify with high specificity and sensitivity the protein profiles of exosomes of different origins, including seven cell lines and two different body fluids. By comparing cells and exosomes, we successfully identified the cells originating the exosomes. Furthermore, by principal component analysis of protein patterns human milk EVs and prostasomes released from prostate acinar cells clustered with cell lines from breast and prostate tissues, respectively. Milk exosomes uniquely expressed CXCL5, MIA and KLK6, while prostasomes carried NKX31, GSTP1 and SRC, highlighting that EVs originating from different origins express distinct proteins. In conclusion, PEA provides a powerful protein screening tool in exosome research, for purposes of identifying the cell source of exosomes, or new biomarkers in diseases such as cancer and inflammation.

  • 115.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Blood pressure and chronic kidney disease progression in a multi-racial cohort: the Multi-Ethnic Study of Atherosclerosis2013Inngår i: Journal of Human Hypertension, ISSN 0950-9240, E-ISSN 1476-5527, Vol. 27, nr 7, s. 403-404Artikkel i tidsskrift (Fagfellevurdert)
  • 116.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Urinanalyser inklusive hematuri och proteinuri.2014Inngår i: Njurmedicin / [ed] Mattias Aurell, Ola Samuelsson, Liber, 2014, s. 44-54Kapittel i bok, del av antologi (Fagfellevurdert)
  • 117.
    Larsson, Anders
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Carlsson, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Gordh, Torsten
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Lind, Anne-Li
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Thulin, Måns
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Statistiska institutionen.
    Kamali-Moghaddam, Masood
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    The effects of age and gender on plasma levels of 63 cytokines2015Inngår i: JIM - Journal of Immunological Methods, ISSN 0022-1759, E-ISSN 1872-7905, Vol. 425, s. 58-61Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cytokines play important roles as regulators of cell functions, and over the last decades a number of cytokine assays have been developed. The aim of the present study was to investigate the effects of age and gender on a large number of cytokines. Plasma samples were collected from 33 healthy blood donors. The samples were analyzed using the multiplex proximity extension assay (PEA) allowing simultaneous measurement of 92 cytokines and four technical controls. Biomarkers with less than 80% quantitative results were excluded leaving 63 cytokines that were analyzed for the effects of gender and age. The plasma level of three of the investigated biomarkers (DNER, MCP-4 and MMP-10) were found to be significantly different for the two genders (adjusted p-value <0.05), and 15 of the biomarkers (CCL11, CCL25, CDCP1, CSF-1, CXCL11, CXCL9, FGF-23, Flt3L, HGF, IL-10RB, MCP-3, MCP-4, MMP-10, OPG, VEGF-A) were significantly associated with age. This study reveals the effects of age and gender on a large number of cytokine assays. CXCL5 and TNFB were significantly higher in females, while the other markers with significant gender-dependent differences were higher in males. For the markers that were significantly associated with age, only CXCL6 was found to decrease with age, while the other biomarkers increased with age.

  • 118.
    Larsson, Anders
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Carlsson, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Lind, Anne-Li
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Gordh, Torsten
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Bodolea, Constantin
    Kamali-Moghaddam, Masood
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Thulin, Måns
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Statistiska institutionen.
    The body mass index (BMI) is significantly correlated with levels of cytokines and chemokines in cerebrospinal fluid2015Inngår i: Cytokine, ISSN 1043-4666, E-ISSN 1096-0023, Vol. 76, nr 2, s. 514-518Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cytokines and chemokines regulate many functions in the body including the brain. The interactions between adipose tissue and the central nervous system (CNS) are important for the regulation of energy balance. CNS function is also influenced by age. The aim of the present study was to investigate the effects of body mass index (BMI) and age on cytokine and chemokine levels in cerebrospinal fluid. Cerebrospinal fluid samples (n=89) were collected from patients undergoing routine surgical procedures. The samples were analyzed using the multiplex proximity extension assay (PEA) in which 92 different cytokines are measured simultaneously using minute sample volume. We found no significant correlations between age and cytokine levels for any of the studied markers. In contrast, at a false discovery rate of 10%, 19 markers were significantly associated with BMI (in decreasing significance: FGF-5, ADA, Beta-NGF, CD40, IL-10RB, CCL19, TGF-alpha, SIRT2, TWEAK, SCF, CSF-1, 4E-BP1, DNER, LIF-R, STAMPB, CXCL10, CXCL6, VEGF-A and CX3CL1). This study reveals a clear effect of BMI on cytokine and chemokine levels in cerebrospinal fluid.

  • 119.
    Larsson, Anders
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Greig-Pylypczuk, Roman
    Huisman, Albert
    The state of point-of-care testing: a european perspective2015Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 120, nr 1, s. 1-10Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Abstract Point-of-care testing (POCT) refers to any diagnostic test administered outside the central laboratory at or near the location of the patient. By performing the sample collection and data analysis steps in the same location POCT cuts down on transport and processing delays, resulting in the rapid feedback of test results to medical decision-makers. Over the past decades the availability and use of POCT have steadily increased in Europe and throughout the international community. However, concerns about overall utility and the reliability of benefits to patient care have impeded the growth of POCT in some areas. While there is no agreed-upon standard for how success should be judged, the increases in speed and mobility provided by POCT can lead to substantial advantages over traditional laboratory testing. When properly utilized, POCT has been shown to yield measurable improvements in patient care, workflow efficiency, and even provide significant financial benefits. However, important organizational and quality assurance challenges must be addressed with the implementation of POCT in any health care environment. To ensure maximal benefits it may be necessary to evaluate critically and restructure existing clinical pathways to capitalize better on the rapid test turnaround times provided by POCT.

  • 120.
    Larsson, Anders
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Hansson, Lars-Olof
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Åkerfeldt, Torbjörn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk endokrinologi.
    Weight reduction is associated with decreased CRP levels2013Inngår i: Clinical Laboratory, ISSN 1433-6510, Vol. 59, nr 9-10, s. 1135-1138Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background:

    Obesity is very costly for society and weight reduction is important to reduce obesity related dis-eases. We have evaluated the effect of weight reduction on CRP values to see if high sensitivity CRP could be used to provide persons on life style intervention programs with positive feedback.

    Methods:

    Study subjects (n = 26) were recruited to a life style intervention program aiming for weight loss among the laboratory staff at Uppsala University Hospital, Sweden. Blood samples for high sensitivity CRP were collect-ed at inclusion and after 4 weeks. Body composition was estimated by measurements performed on an inexpensive bioimpedance analyzer.

    Results:

    CRP reduction was significantly associated with weight reduction after four weeks (p = 0.00005) and eight weeks (p = 0.0002). Data from the bioimpedance analyzer were not useful on an individual level.

    Conclusions:

    High sensitivity CRP could be used to provide positive feedback in workplace weight reduction pro-grams.

  • 121.
    Larsson, Anders
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Nordin, Gunnar
    För kort ”bäst före-datum” ett hot mot patientsäkerheten2014Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 111, artikkel-id C9A6Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • 122.
    Larsson, Anders O
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Specificity of B-type natriuretic peptide assays: Knockin’ on the assay door2017Inngår i: Journal of Laboratory and Precision Medicine, ISSN 2519-9005, Vol. 2, artikkel-id 4Artikkel i tidsskrift (Fagfellevurdert)
  • 123.
    Larsson, Anders
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Ridefelt, Peter
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Melhus, Håkan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk farmakogenomik och osteoporos.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Reference intervals for parathyroid hormone for 70-year-old males and females: exclusion of individuals from the reference interval based on sex, calcium, diabetes, cardiovascular diseases or reduced kidney function has limited effects on the interval2015Inngår i: Annals of Clinical Biochemistry, ISSN 0004-5632, E-ISSN 1758-1001, Vol. 52, nr 1, s. 39-43Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: A problem when producing reference intervals for elderly individuals is that they often suffer from a number of diseases and they are most often on medication. If all such persons are excluded, there is a risk that the residual subgroup may not be representative of the population, we therefore wanted to compare the effects different exclusion criteria has on the reference intervals.

    METHODS: We measured parathyroid hormone (PTH), calcium, albumin and cystatin C in a cohort of 70-year-old males and females (n = 1003). Reference intervals for PTH for males and females were calculated for the entire population and after exclusion of persons with calcium >2.60 mmol/L, calcium >2.51 mmol/L, diabetes, reduced glomerular filtration rate (GFR), and cardiovascular diseases.

    RESULTS: The calculated PTH reference interval 16 (CI 14-17) to 94 (CI 87-101) ng/L. Exclusion of study subjects resulted in smaller reference sample groups, but the reference limits remained within the 90% confidence intervals of the original reference limits. The selections thus had a very limited effect on the calculated reference interval for PTH.

    CONCLUSIONS: Exclusion of elderly individuals with high calcium concentrations, diabetes, reduced GFR or cardiovascular disease has little effect on the reference interval for PTH. It is better not to exclude these individuals, as it will provide a broader base for the reference interval.

  • 124.
    Larsson, Anders
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Ronquist, Göran
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Åkerfeldt, Torbjörn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk endokrinologi.
    Lifestyle intervention is associated with decreased concentrations of circulating pentraxin 3 independent of CRP decrease2013Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 118, nr 3, s. 165-168Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives. Pentraxin 3 (PTX3) is an acute phase marker, which is produced at the site of infection or inflammation in contrast to CRP that is mainly synthesized by the liver. The aim of the present study was to see if lifestyle interventions/weight loss would lead to decreased blood plasma concentrations of PTX3. Methods. Study subjects (n = 31) were recruited to a lifestyle intervention program aiming at increased physical activity, improved eating habits, and weight loss. High-sensitivity C-reactive protein (CRP) and PTX3 methods were used for analysis of CRP and PTX3 in plasma samples collected at inclusion and after 4 and 8 weeks of treatment. Results. Wilcoxon paired samples test showed a significant decrease in PTX3 concentrations from 2068 pg/mL at start to 2007 pg/mL at 4 weeks (P = 0.002) and 1748 pg/mL at 8 weeks (P = 0.003). The PTX3 decrease was not significantly correlated with a corresponding decrease in CRP or weight reduction. Conclusions. The lifestyle intervention program resulted in a significant reduction of circulating concentrations of pentraxin 3 already after 4 and 8 weeks of treatment.

  • 125.
    Larsson, Anders
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Stridsberg, Mats
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk endokrinologi.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Reference values for fasting insulin in 75 year old females and males2013Inngår i: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 46, nr 12, s. 1125-1127Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES:

    Reference intervals for insulin are often based on fairly small study groups with unknown body mass index (BMI). They are also much younger than most patients seeking care. These values are not optimal for elderly patients, as many biological markers change over time and adequate reference intervals are important for correct clinical decisions.

    DESIGN AND METHODS:

    We studied fasting insulin (f-insulin) values in a cohort of 698 75-year old non-diabetic males and females. The 2.5th and 97.5th percentiles for all individuals, males and females were calculated according to the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference intervals.

    RESULTS:

    There was a strong positive correlation between BMI and f-insulin, which led to the calculation of separate reference intervals for individuals with BMI ≤30.

    CONCLUSIONS:

    The reference interval for f-insulin for all study subjects was 1.74-18.27mIU/L and for individuals with BMI ≤30 (n=574) the reference interval was 1.66-15.05mIU/L.

  • 126.
    Larsson, Anders
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Svensson, Michael B
    Ronquist, Göran
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Åkerfeldt, Torbjörn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk endokrinologi.
    Life style intervention in moderately overweight individuals is associated with decreased levels of cathepsins L and S in plasma2014Inngår i: Annals of Clinical and Laboratory Science, ISSN 0091-7370, E-ISSN 1550-8080, Vol. 44, nr 3, s. 283-285Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background Adipose tissue cells produce cathepsins L and S, which have proatherogenic effects. Obesity is strongly linked to atherogenesis, cardiovascular morbidity, and mortality.

    Objective The aim of the present study was to see if life style interventions/weight reduction could decrease cathepsin L and S levels in blood plasma.

    Method Study subjects (n=31) were recruited to a life style intervention program aiming at increased physical activity, more healthy eating habits, and weight reduction for most of the participants. Blood samples were collected at inclusion and after 4 and 8 weeks.

    Results Cathepsin L was significantly reduced at 4 weeks (p<0.0001) and 8 weeks (p=0.0004). A similar reduction was also seen for cathepsin S at 4 weeks (p=0.03) and 8 weeks (p=0.008). No significant change in fractalkine values was observed at 4 weeks (p=0.58), but a significant increase was apparent at 8 weeks (p=0.0002).

    Conclusion The intervention program resulted in significant reductions of cathepsin L and S levels in plasma after 4 and 8 weeks of intervention.

  • 127.
    Larsson, Torsten
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Strandberg, Gunnar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Eriksson, Mats
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Bondesson, Ulf
    National Veterinary Institute (SVA), Department of Chemistry, Environment and Feed Hygiene, Uppsala, Sweden.
    Lipcsey, Miklós
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Intraosseous samples can be used for opioid measurements: An experimental study in the anaesthetized pig2013Inngår i: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 73, nr 2, s. 102-106Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aim.

    The intraosseous route provides access to the systemic circulation in an emergency situation when other forms of vascular access are unavailable and there is an urgent need for fluid or drug therapy. The intraosseous access has also been used for collecting samples for laboratory testing. A question that may arise in an unconscious or severely exhausted patient is whether this condition is caused by an unknown drug. We aimed to evaluate whether intraosseous samples could be used to measure opioids and to study the accuracy and precision of such measurements.

    Methods.

    Five healthy, anaesthetized pigs were treated with a continuous morphine infusion as part of the anaesthesia procedure. Samples for morphine testing were collected hourly for 6 h from two tibial intraosseous cannulae and a central venous catheter.

    Results.

    The differences in morphine concentrations between the two tibial intraosseous cannulae were less than 10% in 32/33 times. The values were also relatively stable over time.

    Conclusion.

    Our findings suggest that intraosseous samples can be used for the analysis of opioids if an IV route is not available.

  • 128. Leion, Felicia
    et al.
    Hegbrant, Josefine
    den Bakker, Emil
    Jonsson, Magnus
    Abrahamson, Magnus
    Nyman, Ulf
    Björk, Jonas
    Lindström, Veronica
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Bökenkamp, Arend
    Grubb, Anders
    Estimating glomerular filtration rate (GFR) in children. The average between a cystatin C- and a creatinine-based equation improves estimation of GFR in both children and adults and enables diagnosing Shrunken Pore Syndrome.2017Inngår i: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 77, nr 5, s. 338-344Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Estimating glomerular filtration rate (GFR) in adults by using the average of values obtained by a cystatin C- (eGFRcystatin C) and a creatinine-based (eGFRcreatinine) equation shows at least the same diagnostic performance as GFR estimates obtained by equations using only one of these analytes or by complex equations using both analytes. Comparison of eGFRcystatin C and eGFRcreatinine plays a pivotal role in the diagnosis of Shrunken Pore Syndrome, where low eGFRcystatin C compared to eGFRcreatinine has been associated with higher mortality in adults. The present study was undertaken to elucidate if this concept can also be applied in children. Using iohexol and inulin clearance as gold standard in 702 children, we studied the diagnostic performance of 10 creatinine-based, 5 cystatin C-based and 3 combined cystatin C-creatinine eGFR equations and compared them to the result of the average of 9 pairs of a eGFRcystatin C and a eGFRcreatinine estimate. While creatinine-based GFR estimations are unsuitable in children unless calibrated in a pediatric or mixed pediatric-adult population, cystatin C-based estimations in general performed well in children. The average of a suitable creatinine-based and a cystatin C-based equation generally displayed a better diagnostic performance than estimates obtained by equations using only one of these analytes or by complex equations using both analytes. Comparing eGFRcystatin and eGFRcreatinine may help identify pediatric patients with Shrunken Pore Syndrome.

  • 129.
    Lim, Stephen S.
    et al.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Allen, Kate
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Bhutta, Zulficiar A.
    Aga Khan Univ, Ctr Excellence Women & Child Hlth, Karachi, Pakistan.;Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Dandona, Lalit
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Publ Hlth Fdn India, New Delhi, India..
    Forouzanfar, Mohammad H.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Fullman, Nancy
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Gething, Peter W.
    Univ Oxford, Dept Zool, Oxford, England..
    Goldberg, Ellen M.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Hay, Simon I.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Holmberg, Mollie
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Kinfu, Yohannes
    Univ Canberra, Fac Hlth, Ctr Res & Act Publ Hlth, Canberra, ACT, Australia..
    Kutz, Michael J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Larson, Heidi J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London, England..
    Liang, Xiaofeng
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Lopez, Alan D.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia..
    Lozano, Rafael
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    McNellan, Claire R.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Mokdad, Ali H.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Mooney, Meghan D.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Naghavi, Mohsen
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Olsen, Helen E.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Pigott, David M.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Salomon, Joshua A.
    Harvard Univ, Dept Global Hlth & Populat, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Vos, Theo
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Wang, Haidong
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Abajobir, Amanuel Alemu
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Abate, Kalkidan Hassen
    Jimma Univ, Jimma, Ethiopia..
    Abbafati, Cristiana
    Univ Roma La Sapienza, Rome, Italy..
    Abbas, Kaja M.
    Virginia Tech, Blacksburg, VA USA..
    Abd-Allah, Foad
    Cairo Univ, Dept Neurol, Cairo, Egypt..
    Abdulle, Abdishakur M.
    New York Univ Abu Dhabi, Abu Dhabi, U Arab Emirates..
    Abraham, Biju
    NMSM Govt Coll Kalpetta, Kalpetta, Kerala, India..
    Abubakar, Ibrahim
    UCL, Inst Global Hlth, London, England..
    Abu-Raddad, Laith J.
    Weill Cornell Med Coll Qatar, Infect Dis Epidemiol Grp, Doha, Qatar..
    Abu-Rmeileh, Niveen M. E.
    Birzeit Univ, Inst Community & Publ Hlth, Ramallah, Israel..
    Abyu, Gebre Yitayih
    Mekelle Univ, Mekelle, Ethiopia..
    Achoki, Tom
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Adebiyi, Akindele Olupelumi
    Univ Ibadan, Coll Med, Ibadan, Nigeria.;Univ Coll Hosp, Ibadan, Nigeria..
    Adedeji, Isaac Akinkunmi
    Olabisi Onabanjo Univ, Ago Iwoye, Nigeria..
    Afanvi, Kossivi Agbelenko
    Direct Dist Sanitaire Haho, Notse, Togo.;Univ Lome, Fac Sci Sante, Lome, Togo..
    Afshin, Ashkan
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA..
    Agarwal, Arnav
    McMaster Univ, Hamilton, ON, Canada..
    Agrawal, Anurag
    CSIR Inst Genom & Integrat Biol, Delhi, India.;Baylor Coll Med, Dept Internal Med, Houston, TX 77030 USA..
    Kiadaliri, Aliasghar Ahmad
    Ahmadieh, Hamid
    Ahmed, Kedir Yimam
    Debre Markos Univ, Debre Markos, Ethiopia..
    Akanda, Ali Shafqat
    Univ Rhode Isl, Kingston, RI 02881 USA..
    Akinyemi, Rufus Olusola
    Univ Ibadan, Ibadan, Nigeria.;Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England..
    Akinyemiju, Tomi F.
    Akseer, Nadia
    Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Al-Aly, Ziyad
    Washington Univ, St Louis, MO USA..
    Alam, Khurshid
    Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Alam, Uzma
    Int Ctr Humanitarian Affairs, Nairobi, Kenya..
    Alasfoor, Deena
    AlBuhairan, Fadia S.
    Aldhahri, Saleh Fahed
    King Saud Univ, Riyadh, Saudi Arabia..
    Dge, Robert William Aldr.
    UCL, Inst Global Hlth, London, England.;UCL, Ctr Publ Hlth Data Sci, Inst Hlth Informat, London, England.;UCL, Farr Inst Hlth Informat Res, London, England..
    Alemu, Zewdie Aderaw
    Debre Markos Univ, Debre Markos, Ethiopia..
    Ali, Raghib
    Univ Oxford, Oxford, England..
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Strassen, Luxembourg..
    Alkhateeb, Mohammad A. B.
    King Saud Univ, King Khalid Univ Hosp, Riyadh, Saudi Arabia..
    Alla, Francois
    Univ Lorraine, Sch Publ Hlth, Nancy, France..
    Allebeck, Peter
    Allen, Christine
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Al-Raddadi, Rajaa
    Minist Hlth, Jeddah, Saudi Arabia..
    Altirkawi, Khalid A.
    King Saud Univ, Riyadh, Saudi Arabia..
    Martin, Elena Alvarez
    Govt Madrid, Madrid, Spain..
    Alvis-Guzman, Nelson
    Univ Cartagena, Cartagena, Colombia..
    Amare, Azmeraw T.
    Univ Adelaide, Sch Med, Adelaide, SA, Australia.;Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia..
    Amberbir, Alemayehu
    Dignitas Int, Zomba, Malawi..
    Amegah, Adeladza Kofi
    Univ Cape Coast, Cape Coast, Ghana..
    Amini, Heresh
    Kurdistan Univ Med Sci, Environm Hlth Res Ctr, Sanandaj, Iran.;Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland..
    Ammar, Walid
    Amrock, Stephen Marc
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Andersen, Hjalte H.
    Aalborg Univ, Fac Med, Dept Hlth Sci & Technol, Ctr Sensory Motor Interact, Aalborg, Denmark..
    Anderson, Benjamin O.
    Univ Washington, Seattle, WA 98121 USA..
    Anderson, Gregory M.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Antonio, Carl Abelardo T.
    Univ Philippines Manila, Coll Publ Hlth, Dept Hlth Policy & Adm, Manila, Philippines..
    Anwari, Palwasha
    Ärnlöv, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi. Dalarna Univ, Falun, Sweden..
    Artaman, Al
    Univ Manitoba, Winnipeg, MB, Canada..
    Asayesh, Hamid
    Qom Univ Med Sci, Sch Paramed, Dept Emergency Med, Qom, Iran..
    Asghar, Rana Jawad
    South Asian Publ Hlth Forum, Islamabad, Pakistan..
    Atique, Suleman
    Taipei Med Univ, Grad Inst Biomed Informat, Taipei, Taiwan..
    Avokpaho, Euripide Frinel G. Arthur
    Inst Rech Clin Benin, Cotonou, Benin.;LERAS Afrique, Parakou, Benin..
    Awasthi, Ashish
    Sanjay Gandhi Postgrad Inst Med Sci, Lucknow, Uttar Pradesh, India..
    Quintanilla, Beatriz Paulina Ayala
    La Trobe Univ, Judith Lumley Ctr Mother Infant & Family Hlth Res, Melbourne, Vic, Australia.;Peruvian Natl Inst Hlth, Lima, Peru..
    Azzopardi, Peter
    Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia.;Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;South Australian Hlth & Med Res Inst, Wardliparingga Aboriginal Res Unit, Adelaide, SA, Australia.;Burnet Inst, Ctr Int Hlth, Melbourne, Vic, Australia..
    Bacha, Umar
    Univ Management & Technol, Sch Hlth Sci, Lahore, Pakistan..
    Badawi, Alaa
    Publ Hlth Agcy Canada, Toronto, ON, Canada..
    Balakrishnan, Kalpana
    Sri Ramachandra Univ, Dept Environm Hlth Engn, Chennai, Tamil Nadu, India..
    Banerjee, Amitava
    UCL, Farr Inst Hlth Informat Res, London, England..
    Barac, Aleksandra
    Univ Belgrade, Fac Med, Belgrade, Serbia..
    Barber, Ryan
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Barker-Collo, Suzanne L.
    Univ Auckland, Sch Psychol, Auckland, New Zealand..
    Barnighausen, Till
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Africa Hlth Res Inst, Mtubatuba, South Africa.;Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Barrero, Lope H.
    Pontificia Univ Javeriana, Sch Engn, Dept Ind Engn, Bogota, Colombia..
    Barrientos-Gutierrez, Tonatiuh
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Basu, Sanjay
    Stanford Univ, Stanford, CA 94305 USA..
    Bayou, Tigist Assefa
    Mekelle Univ, Mekelle, Ethiopia..
    Bazargan-Hejazi, Shahrzad
    Charles R Drew Univ Med & Sci, Coll Med, 1621 E 120th St, Los Angeles, CA 90059 USA.;Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.;Kermanshah Univ Med Sci, Kermanshah, Iran..
    Beardsley, Justin
    Univ Oxford, Ho Chi Minh City, Vietnam..
    Bedi, Neeraj
    Coll Publ Hlth & Trop Med, Jazan, Saudi Arabia..
    Beghi, Ettore
    IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy..
    Bejot, Yannick
    Univ Burgundy, Univ Hosp & Med Sch Dijon, Dijon, France..
    Bell, Michelle L.
    Yale Univ, Sch Med, New Haven, CT USA..
    Bello, Aminu K.
    Univ Alberta, Edmonton, AB, Canada..
    Bennett, Derrick A.
    Univ Oxford, Oxford, England..
    Bensenor, Isabela M.
    Univ Sao Paulo, Sao Paulo, Brazil..
    Benzian, Habib
    UCL, Dept Epidemiol & Publ Hlth, London, England.;NYU, Coll Dent, Dept Epidemiol & Hlth Promot, New York, NY USA..
    Berhane, Adugnaw
    Debre Berhane Univ, Debre Berhan, Ethiopia..
    Bernabe, Eduardo
    Kings Coll London, London, England..
    Bernal, Oscar Alberto
    Univ Andes, Bogota, Colombia. Haramaya Univ, Coll Hlth & Med Sci, Harar, Ethiopia..
    Betsu, Balem Demtsu
    Mekelle Univ, Mekelle, Ethiopia..
    Beyene, Addisu Shunu
    Haramaya Univ, Harar, Ethiopia..
    Bhala, Neeraj
    Queen Elizabeth Hosp Birmingham, Birmingham, W Midlands, England.;Univ Otago, Sch Med, Wellington, New Zealand..
    Bhatt, Samir
    Imperial Coll, London, England..
    Biadgilign, Sibhatu
    Bienhoff, Kelly A.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Bikbov, Boris
    Academician VI Shumakov Fed Res Ctr Transplantol, Issues Transplanted Kidney, Dept Nephrol, Moscow, Russia..
    Binagwaho, Agnes
    Harvard Univ, Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA 02115 USA.;Dartmouth Coll, Dept Pediat, Hanover, NH 03755 USA.;Dartmouth Coll, Dartmouth Inst Hlth Policy & Clin Practice, Geisel Sch Med, Hanover, NH 03755 USA.;Univ Global Hlth Equ, Kigali, Rwanda..
    Bisanzio, Donal
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Bjertness, Espen
    Univ Oslo, Dept Community Med, Oslo, Norway..
    Blore, Jed
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Bourne, Rupert R. A.
    Anglia Ruskin Univ, Vis Eye Res Unit, Cambridge, England..
    Brainin, Michael
    Danube Univ Krems, Krems, Austria..
    Brauer, Michael
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ British Columbia, Vancouver, BC, Canada..
    Brazinova, Alexandra
    Trnava Univ, Dept Publ Hlth, Fac Hlth Sci & Social Work, Trnava, Slovakia.;Int Neurotrauma Res Org, Vienna, Austria..
    Breitborde, Nicholas J. K.
    Ohio State Univ, Coll Med, Columbus, OH 43210 USA..
    Broday, David M.
    Technion, Haifa, Israel..
    Brugha, Traolach S.
    Univ Leicester, Leicester, Leics, England..
    Buchbinder, Rachelle
    Cabrini Inst, Monash Dept Clin Epidemiol, Melbourne, Vic, Australia.;Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia..
    Butt, Zahid A.
    Al Shifa Trust Eye Hosp, Rawalpindi, Pakistan..
    Cahill, Leah E.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Dalhousie Univ, Halifax, NS, Canada..
    Campos-Nonato, Ismael Ricardo
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico.;Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Campuzano, Julio Cesar
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Carabin, Helene
    Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, Oklahoma City, OK USA..
    Cardenas, Rosario
    Metropolitan Autonomous Univ, Mexico City, DF, Mexico..
    Carrero, Juan Jesus
    Carter, Austin
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Casey, Daniel
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Caso, Valeria
    Univ Perugia, Stroke Unit, Perugia, Italy..
    Castaneda-Orjuela, Carlos A.
    Inst Nacl Salud, Colombian Natl Hlth Observ, Bogota, Colombia.;Univ Nacl Colombia, Dept Publ Hlth, Epidemiol & Publ Hlth Evaluat Grp, Bogota, Colombia..
    Rivas, Jacqueline Castillo
    Caja Costarricense Seguro Social, San Jose, Costa Rica.;Univ Costa Rica, San Pedro, Montes De Oca, Costa Rica..
    Catala-Lopez, Ferran
    Cavalleri, Fiorella
    Cecilio, Pedro
    Chang, Hsing-Yi
    Chang, Jung-Chen
    Charlson, Fiona J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Che, Xuan
    Chen, Alan Zian
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Chiang, Peggy Pei-Chia
    Chibalabala, Mirriam
    Chisumpa, Vesper Hichilombwe
    Choi, Jee-Young Jasmine
    Chowdhury, Rajiv
    Christensen, Hanne
    Ciobanu, Liliana G.
    Univ Adelaide, Adelaide, SA, Australia..
    Cirillo, Massimo
    Coates, Matthew M.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Coggeshall, Megan
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Cohen, Aaron J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Cooke, Graham S.
    Cooper, Cyrus
    Univ Oxford, NIHR Musculoskeletal Biomed Res Ctr, Oxford, England..
    Cooper, Leslie Trumbull
    Cowie, Benjamin C.
    Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia..
    Crump, John A.
    Damtew, Solomon Abrha
    Dandona, Rakhi
    Publ Hlth Fdn India, New Delhi, India..
    Dargan, Paul I.
    das Neves, Jose
    Davis, Adrian C.
    Davletov, Kairat
    de Castro, E. Filipa
    De Leo, Diego
    Degenhardt, Louisa
    Del Gobbo, Liana C.
    Stanford Univ, Stanford, CA 94305 USA..
    Deribe, Kebede
    Derrett, Sarah
    Jarlais, Don C. Des
    Deshpande, Aniruddha
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    deVeber, Gabrielle A.
    Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Dey, Subhojit
    Dharmaratne, Samath D.
    Dhillon, Preet K.
    Ding, Eric L.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Dorsey, E. Ray
    Doyle, Kerrie E.
    Driscoll, Tim R.
    Duan, Leilei
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Dubey, Manisha
    Duncan, Bruce Bartholow
    Ebrahimi, Hedyeh
    Endries, Aman Yesuf
    Ermakov, Sergey Petrovich
    Erskine, Holly E.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Eshrati, Babak
    Esteghamati, Alireza
    Fahimi, Saman
    Farid, Talha A.
    Farinha, Carla Sofia e Sa
    Faro, Andre
    Farvid, Maryam S.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Farzadfar, Farshad
    Feigin, Valery L.
    Felicio, Manuela Mendonca
    Fereshtehnejad, Seyed-Mohammad
    Fernandes, Jefferson G.
    Fernandes, Joao C.
    Ferrari, Alize J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Fischer, Florian
    Fitchett, Joseph R. A.
    Harvard Univ, Boston, MA 02115 USA..
    Fitzmaurice, Christina
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Foigt, Nataliya
    Foreman, Kyle
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Fowkes, F. Gerry R.
    Franca, Elisabeth Barboza
    Franklin, Richard C.
    Fraser, Maya
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Friedman, Joseph
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Frostad, Joseph
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Furst, Thomas
    Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland..
    Gabbe, Belinda
    Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia..
    Garcia-Basteiro, Alberto L.
    Gebre, Teshome
    Gebrehiwot, Tsegaye Tewelde
    Jimma Univ, Jimma, Ethiopia..
    Gebremedhin, Amanuel Tesfay
    Jimma Univ, Jimma, Ethiopia..
    Gebru, Alemseged Aregay
    Mekelle Univ, Mekelle, Ethiopia..
    Gessner, Bradford D.
    Gillum, Richard F.
    Ginawi, Ibrahim Abdelmageem Mohamed
    Giref, Ababi Zergaw
    Giroud, Maurice
    Gishu, Melkamu Dedefo
    Godwin, William
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Gona, Philimon
    Goodridge, Amador
    Gopalani, Sameer Vali
    Gotay, Carolyn C.
    Univ British Columbia, Vancouver, BC, Canada..
    Goto, Atsushi
    Gouda, Hebe N.
    Univ Queensland, Brisbane, Qld, Australia..
    Graetz, Nicholas
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Greenwell, Karen Fern
    Griswold, Max
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Guo, Yuming
    Univ Queensland, Brisbane, Qld, Australia..
    Gupta, Rahul
    Gupta, Rajeev
    Gupta, Vipin
    Gutierrez, Reyna A.
    Gyawali, Bishal
    Haagsma, Juanita A.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Haakenstad, Annie
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Hafezi-Nejad, Nima
    Haile, Demewoz
    Hailu, Gessessew Bugssa
    Mekelle Univ, Mekelle, Ethiopia..
    Halasa, Yara A.
    Hamadeh, Randah Ribhi
    Hamidi, Samer
    Hammami, Mouhanad
    Hankey, Graeme J.
    Harb, Hilda L.
    Minist Publ Hlth, Beirut, Lebanon..
    Haro, Josep Maria
    Hassanvand, Mohammad Sadegh
    Havmoeller, Rasmus
    Heredia-Pi, Ileana Beatriz
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Hoek, Hans W.
    Horino, Masako
    Horita, Nobuyuki
    Hosgood, H. Dean
    Hoy, Damian G.
    Htet, Aung Soe
    Univ Oslo, Oslo, Norway..
    Hu, Guoqing
    Huang, Hsiang
    Iburg, Kim Moesgaard
    Idrisov, Bulat T.
    Inoue, Manami
    Islami, Farhad
    Jacobs, Troy A.
    Jacobsen, Kathryn H.
    Jahanmehr, Nader
    Jakovljevic, Mihajlo B.
    James, Peter
    Harvard Univ, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Channing Div Network Med, Brigham & Womens Hosp, Harvard Med Sch, Boston, MA 02115 USA..
    Jansen, Henrica A. F. M.
    Javanbakht, Mehdi
    Jayatilleke, Achala Upendra
    Jee, Sun Ha
    Jeemon, Panniyammakal
    Publ Hlth Fdn India, Ctr Control Chron Condit, New Delhi, India..
    Jha, Vivekanand
    Univ Oxford, Oxford, England..
    Jiang, Ying
    Jibat, Tariku
    Jin, Ye
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Jonas, Jost B.
    Kabir, Zubair
    Kalkonde, Yogeshwar
    Kamal, Ritul
    Kan, Haidong
    Kandel, Amit
    Karch, Andre
    Karema, Corine Kakizi
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland..
    KarimIchani, Chante
    Karunapema, Palitha
    Kasaeian, Amir
    Kassebaum, Nicholas J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Kaul, Anil
    Kawakami, Norito
    Kayibanda, Jeanne Francoise
    Keiyoro, Peter Njenga
    Kemmer, Laura
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Kemp, Andrew Haddon
    Kengne, Andre Pascal
    Keren, Andre
    Kesavachandran, Chandrasekharan Nair
    Khader, Yousef Saleh
    Khan, Abdur Rahman
    Khan, Ejaz Ahmad
    Khan, Gulfaraz
    Khang, Young-Ho
    Khoja, Tawfik Ahmed Muthafer
    Khosravi, Ardeshir
    Khubchandani, Jagdish
    Kieling, Christian
    Kim, Cho-il
    Kim, Daniel
    Kim, Sungroul
    Kim, Yun Jin
    Kimokoti, Ruth W.
    Kissoon, Niranjan
    Univ British Columbia, Vancouver, BC, Canada..
    Kivipelto, Miia
    Knibbs, Luke D.
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Kokubo, Yoshihiro
    Kolte, Dhaval
    Kosen, Soewarta
    Kotsakis, Georgios A.
    Univ Washington, Sch Dent, Seattle, WA 98121 USA..
    Koul, Parvaiz A.
    Koyanagi, Ai
    Kravchenko, Michael
    Krueger, Hans
    Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada..
    Defo, Barthelemy Kuate
    Kuchenbecker, Ricardo S.
    Kuipers, Ernst J.
    Kulikoff, Xie Rachel
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Kulkarni, Veena S.
    Kumar, G. Anil
    Publ Hlth Fdn India, New Delhi, India..
    Kwan, Gene F.
    Kyu, Hmwe H.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Lal, Aparna
    Lal, Dharmesh Kumar
    Lalloo, Ratilal
    Univ Queensland, Sch Dent, Brisbane, Qld, Australia..
    Lam, Hilton
    Lan, Qing
    Langan, Sinead M.
    London Sch Hyg & Trop Med, London, England..
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Laryea, Dennis Odai
    Latif, Asma Abdul
    Leasher, Janet L.
    Leigh, James
    Leinsalu, Mall
    Leung, Janni
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Leung, Ricky
    Levi, Miriam
    Li, Yichong
    Li, Yongmei
    Lind, Margaret
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Linn, Shai
    Lipshultz, Steven E.
    Liu, Patrick Y.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Liu, Shiwei
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Liu, Yang
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Lloyd, Belinda K.
    Lo, Loon-Tzian
    Logroscino, Giancarlo
    Lotufo, Paulo A.
    Univ Sao Paulo, Sao Paulo, Brazil..
    Lucas, Robyn M.
    Lunevicius, Raimundas
    Abd El Razek, Mohammed Magdy
    Magis-Rodriguez, Carlos
    Mandavi, Mandi
    Majdan, Marek
    Trnava Univ, Dept Publ Hlth, Fac Hlth Sci & Social Work, Trnava, Slovakia..
    Majeed, Azeem
    Malekzadeh, Reza
    Malta, Deborah Carvalho
    Mapoma, Chabila C.
    Margolis, David Joel
    Martin, Randall V.
    Dalhousie Univ, Halifax, NS, Canada..
    Martinez-Raga, Jose
    Masiye, Felix
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Mason-Jones, Amanda J.
    Massano, Joao
    Matzopoulos, Richard
    Mayosi, Bongani M.
    McGrath, John J.
    Univ Queensland, Brisbane, Qld, Australia..
    McKee, Martin
    London Sch Hyg & Trop Med, London, England..
    Meaney, Peter A.
    Mehari, Alem
    Mekonnen, Alemayehu B.
    Melaku, Yohannes Adama
    Mekelle Univ, Sch Publ Hlth, Mekelle, Ethiopia.;Univ Adelaide, Sch Med, Adelaide, SA, Australia..
    Memiah, Peter
    Memish, Ziad A.
    Mendoza, Walter
    Mensink, Gert B. M.
    Meretoja, Atte
    Univ Melbourne, Dept Med, Melbourne, Vic, Australia..
    Meretoja, Tuomo J.
    Mesfin, Yonatan Moges
    Haramaya Univ, Harar, Ethiopia..
    Mhimbira, Francis Apolinary
    Micha, Renata
    Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA..
    Miller, Ted R.
    Mills, Edward J.
    Mirarefin, Mojde
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Misganaw, Awoke
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Mitchell, Philip B.
    Mock, Charles N.
    Univ Washington, Harborview Injury Prevent & Res Ctr, Seattle, WA 98121 USA..
    Mohammadi, Alireza
    Mohammed, Shafiu
    Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Monasta, Lorenzo
    Monis, Jonathan de la Cruz
    Hernandez, Julio Cesar Montanez
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Montico, Marcella
    Moradi-Lakeh, Maziar
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Morawska, Lidia
    Mori, Rintaro
    Mueller, Ulrich O.
    Murdoch, Michele E.
    Murimira, Brighton
    Murray, Joseph
    Murthy, Gudlavalleti Venkata Satyanarayana
    London Sch Hyg & Trop Med, London, England..
    Murthy, Srinivas
    Univ British Columbia, Vancouver, BC, Canada..
    Musa, Kamarul Imran
    Nachega, Jean B.
    Nagel, Gabriele
    Naidoo, Kovin S.
    Naldi, Luigi
    Nangia, Vinay
    Neal, Bruce
    Nejjari, Chakib
    Newton, Charles R.
    Newton, John N.
    Ngalesoni, Frida Namnyak
    Nguhiu, Peter
    Nguyen, Grant
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Nguyen, Quyen Le
    Nisar, Muhammad Imran
    Aga Khan Univ, Karachi, Pakistan..
    Pete, Patrick Martial Nkamedjie
    Nolte, Sandra
    Nomura, Marika
    Norheim, Ole F.
    Norrving, Bo
    Obermeyer, Carla Makhlouf
    Ogbo, Felix Akpojene
    Oh, In-Hwan
    Oladimeji, Olanrewaju
    Olivares, Pedro R.
    Olusanya, Bolajoko Olubukunola
    Olusanya, Jacob Olusegun
    Opio, John Nelson
    Oren, Eyal
    Ortiz, Alberto
    Osborne, Richard H.
    Ota, Erika
    Owolabi, Mayowa O.
    Univ Ibadan, Dept Med, Ibadan, Nigeria..
    Mahesh, P. A.
    Park, Eun-Kee
    Park, Hye-Youn
    Parry, Charles D.
    Parsaeian, Mahboubeh
    Patel, Tejas
    Patel, Vikram
    London Sch Hyg & Trop Med, Ctr Global Mental Hlth, London, England..
    Caicedo, Angel J. Paternina
    Univ Cartagena, Cartagena, Colombia..
    Patil, Snehal T.
    Patten, Scott B.
    Patton, George C.
    Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia..
    Paudel, Deepak
    Pedro, Joao Mario
    Pereira, David M.
    Perico, Norberto
    Pesudovs, Konrad
    Petzold, Max
    Phillips, Michael Robert
    Piel, Frederic B.
    Pillay, Julian David
    Pinho, Christine
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Pishgar, Farhad
    Polinder, Suzanne
    Poulton, Richie G.
    Pourmalek, Farshad
    Univ British Columbia, Vancouver, BC, Canada..
    Qorbani, Mostafa
    Rabiee, Rynaz H. S.
    Radfar, Amir
    Rahimi-Movaghar, Vafa
    Rahman, Mahfuzar
    Rahman, Mohammad Hifz Ur
    Rahman, Sajjad Ur
    Rai, Rajesh Kumar
    Rajsic, Sasa
    Raju, Murugesan
    Ram, Usha
    Rana, Saleem M.
    Ranabhat, Chhabi Lal
    Ranganathan, Kavitha
    Rao, Puja C.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Refaat, Amany H.
    Reitsma, Marissa B.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Remuzzi, Giuseppe
    Resnikoff, Serge
    Ribeiro, Antonio L.
    Blancas, Maria Jesus Rios
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Rolm, Hirbo Shore
    Roberts, Bayard
    London Sch Hyg & Trop Med, London, England..
    Rodriguez, Mina
    Rojas-Rueda, David
    Ronfani, Luca
    Roshandel, Gholamreza
    Roth, Gregory A.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Rothenbacher, Dietrich
    Roy, Ambuj
    Roy, Nobhojit
    Sackey, Ben Benasco
    Sagar, Rajesh
    Saleh, Muhammad Muhammad
    Sanabria, Juan R.
    Santomauro, Damian F.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Santos, Itamar S.
    Univ Sao Paulo, Dept Internal Med, Sao Paulo, Brazil..
    Sarmiento-Suarez, Rodrigo
    Sartorius, Benn
    Satpathy, Maheswar
    Savic, Miloje
    Sawhney, Monika
    Sawyer, Susan M.
    Univ Melbourne, Dept Pediat, Melbourne, Vic, Australia..
    Schmidhuber, Josef
    Schmidt, Maria Ines
    Schneider, Ione J. C.
    Schutte, Aletta E.
    Schwebel, David C.
    Seedat, Soraya
    Sepanlou, Sadaf G.
    Servan-Mori, Edson E.
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Shackelford, Katya
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Shaheen, Amira
    Shaikh, Masood Ali
    Levy, Teresa Shamah
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Sharma, Rajesh
    She, Jun
    Sheikhbahaei, Sara
    Shen, Jiabin
    Sheth, Kevin N.
    Shey, Muki
    Shi, Peilin
    Tufts Univ, Boston, MA 02111 USA..
    Shibuya, Kenji
    Shigematsu, Mika
    Shin, Min-Jeong
    Shiri, Rahman
    Shishani, Kawkab
    Shiue, Ivy
    Sigfusdottir, Inga Dora
    Silpakit, Naris
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Silva, Diego Augusto Santos
    Silverberg, Jonathan I.
    Simard, Edgar P.
    Sindi, Shireen
    Singh, Abhishek
    Singh, Gitanjali M.
    Tufts Univ, Boston, MA 02111 USA..
    Singh, Jasvinder A.
    Singh, Om Prakash
    Singh, Prashant Kumar
    Skirbekk, Vegard
    Sligar, Amber
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Soneji, Samir
    Dartmouth Coll, Hanover, NH 03755 USA..
    Soreide, Kjetil
    Sorensen, Reed J. D.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Soriano, Joan B.
    Soshnikov, Sergey
    Sposato, Luciano A.
    Sreeramareddy, Chandrashekhar T.
    Stahl, Hans-Christian
    Stanaway, Jeffrey D.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Stathopoulou, Vasiliki
    Steckling, Nadine
    Steel, Nicholas
    Stein, Dan J.
    Steiner, Caitlyn
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Stockl, Heidi
    London Sch Hyg & Trop Med, London, England..
    Stranges, Saverio
    Strong, Mark
    Sun, Jiandong
    Sunguya, Bruno F.
    Sur, Patrick
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Swaminathan, Soumya
    Sykes, Bryan L.
    Szoeke, Cassandra E. I.
    Univ Melbourne, Inst Hlth & Ageing, Melbourne, Vic, Australia..
    Tabares-Seisdedos, Rafael
    Tabb, Karen M.
    Talongwa, Roberto Tchio
    Tarawneh, Mohammed Rasoul
    Tavakkoli, Mohammad
    Taye, Bineyam
    Taylor, Hugh R.
    Univ Melbourne, Melbourne, Vic, Australia..
    Tedla, Bemnet Amare
    Tefera, Worku
    Tegegne, Teketo Kassaw
    Debre Markos Univ, Debre Markos, Ethiopia..
    Tekle, Dejen Yemane
    Mekelle Univ, Mekelle, Ethiopia..
    Shifa, Girma Temam
    Terkawi, Abdullah Sulieman
    Tessema, Gizachew Assefa
    Univ Adelaide, Adelaide, SA, Australia..
    Thakur, J. S.
    Thomson, Alan J.
    Thorne-Lyman, Andrew L.
    Harvard Univ, Dept Nutr, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Thrift, Amanda G.
    Monash Univ, Dept Med, Sch Clin Sci, Monash Hlth, Melbourne, Vic, Australia..
    Thurston, George D.
    Tillmann, Taavi
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Tobe-Gai, Ruoyan
    Tonelli, Marcelo
    Topor-Madry, Roman
    Topouzis, Fotis
    Tran, Bach Xuan
    Dimbuene, Zacharie Tsala
    Tura, Abera Kenay
    Tuzcu, Emin Murat
    Tyrovolas, Stefanos
    Ukwaja, Kingsley Nnanna
    Undurraga, Eduardo A.
    Uneke, Chigozie Jesse
    Uthman, Olalekan A.
    van Donkelaar, Aaron
    Dalhousie Univ, Dept Phys & Atmospher Sci, Halifax, NS, Canada..
    Varakin, Yuri Y.
    Vasankari, Tommi
    Vasconcelos, Ana Maria Nogales
    Veerman, J. Lennert
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Venketasubramanian, Narayanaswamy
    Verma, Raj Kumar
    Violante, Francesco S.
    Vlassov, Vasiliy Victorovich
    Volkow, Patricia
    Vollset, Stein Emil
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Wagner, Gregory R.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Wallin, Mitchell T.
    Wang, Linhong
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Wanga, Valentine
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Watkins, David A.
    Univ Washington, Seattle, WA 98121 USA..
    Weichenthal, Scott
    Weiderpass, Elisabete
    Weintraub, Robert G.
    Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Weiss, Daniel J.
    Univ Oxford, Oxford, England..
    Werdecker, Andrea
    Westerman, Ronny
    Whiteford, Harvey A.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Wilkinson, James D.
    Wiysonge, Charles Shey
    Wolfe, Charles D. A.
    Kings Coll London, Div Hlth & Social Care Res, London, England..
    Wolfe, Ingrid
    Kings Coll London, London, England..
    Won, Sungho
    Woolf, Anthony D.
    Workie, Shimelash Bitew
    Wubshet, Mamo
    Xu, Gelin
    Yadav, Ajit Kumar
    Yakob, Bereket
    Yalew, Ayalnesh Zemene
    Mekelle Univ, Mekelle, Ethiopia..
    Yan, Lijing L.
    Yano, Yuichiro
    Yaseri, Mehdi
    Ye, Pengpeng
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Yip, Paul
    Univ Hong Kong, Social Work & Social Adm Dept, Hong Kong, Hong Kong, Peoples R China.;Univ Hong Kong, Hong Kong Jockey Club Ctr Suicide Res & Prevent, Hong Kong, Hong Kong, Peoples R China..
    Yonemoto, Naohiro
    Kyoto Univ, Sch Publ Hlth, Dept Biostat, Kyoto, Japan..
    Yoon, Seok-Jun
    Younis, Mustafa Z.
    Jackson State Univ, Jackson, MS USA..
    Yu, Chuanhua
    Zaidi, Zoubida
    Zaki, Maysaa El Sayed
    Zambrana-Torrelio, Carlos
    Zapata, Tomas
    Zegeye, Elias Asfaw
    Ethiopian Publ Hlth Inst, Addis Ababa, Ethiopia..
    Zhao, Yi
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Zhou, Maigeng
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Zodpey, Sanjay
    Zonies, David
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Murray, Christopher J. L.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 20152016Inngår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 388, nr 10053, s. 1813-1850Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background In September, 2015, the UN General Assembly established the Sustainable Development Goals (SDGs). The SDGs specify 17 universal goals, 169 targets, and 230 indicators leading up to 2030. We provide an analysis of 33 health-related SDG indicators based on the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015). Methods We applied statistical methods to systematically compiled data to estimate the performance of 33 health-related SDG indicators for 188 countries from 1990 to 2015. We rescaled each indicator on a scale from 0 (worst observed value between 1990 and 2015) to 100 (best observed). Indices representing all 33 health-related SDG indicators (health-related SDG index), health-related SDG indicators included in the Millennium Development Goals (MDG index), and health-related indicators not included in the MDGs (non-MDG index) were computed as the geometric mean of the rescaled indicators by SDG target. We used spline regressions to examine the relations between the Socio-demographic Index (SDI, a summary measure based on average income per person, educational attainment, and total fertility rate) and each of the health-related SDG indicators and indices. Findings In 2015, the median health-related SDG index was 59.3 (95% uncertainty interval 56.8-61.8) and varied widely by country, ranging from 85.5 (84.2-86.5) in Iceland to 20.4 (15.4-24.9) in Central African Republic. SDI was a good predictor of the health-related SDG index (r(2) = 0.88) and the MDG index (r(2) = 0.2), whereas the non-MDG index had a weaker relation with SDI (r(2) = 0.79). Between 2000 and 2015, the health-related SDG index improved by a median of 7.9 (IQR 5.0-10.4), and gains on the MDG index (a median change of 10.0 [6.7-13.1]) exceeded that of the non-MDG index (a median change of 5.5 [2.1-8.9]). Since 2000, pronounced progress occurred for indicators such as met need with modern contraception, under-5 mortality, and neonatal mortality, as well as the indicator for universal health coverage tracer interventions. Moderate improvements were found for indicators such as HIV and tuberculosis incidence, minimal changes for hepatitis B incidence took place, and childhood overweight considerably worsened. Interpretation GBD provides an independent, comparable avenue for monitoring progress towards the health-related SDGs. Our analysis not only highlights the importance of income, education, and fertility as drivers of health improvement but also emphasises that investments in these areas alone will not be sufficient. Although considerable progress on the health-related MDG indicators has been made, these gains will need to be sustained and, in many cases, accelerated to achieve the ambitious SDG targets. The minimal improvement in or worsening of health-related indicators beyond the MDGs highlight the need for additional resources to effectively address the expanded scope of the health-related SDGs.

  • 130.
    Lind, Anne-Li
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Wu, Di
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Freyhult, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Cancerfarmakologi och beräkningsmedicin.
    Bodolea, Constantin
    University of Cluj Napoca, Cluj Napoca, Romania.
    Ekegren, Titti
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Gustafsson, Mats
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Cancerfarmakologi och beräkningsmedicin.
    Bergquist, Jonas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC.
    Gordh, Torsten
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Landegren, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Kamali-Moghaddam, Masood
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Analyses of CSF reveal decreased levels of four proteins in ALS patients, but no changes upon analgesia in patients with neuropathic painManuskript (preprint) (Annet (populærvitenskap, debatt, mm))
  • 131.
    Lind, Anne-Li
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Yu, Di
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    Freyhult, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Cancerfarmakologi och beräkningsmedicin.
    Bodolea, Constantin
    Department of Anaesthesia and Intensive Care, University of Medicine and Pharmacy, Cluj, Napoca, Romania..
    Ekegren, Titti
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Gustafsson, Mats G
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Cancerfarmakologi och beräkningsmedicin.
    Katila, Lenka
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Bergquist, Jonas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Gordh, Torsten
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Landegren, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    Kamali-Moghaddam, Masood
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients2016Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, nr 2, artikkel-id e0149821Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The objective of this study was to develop and apply a novel multiplex panel of solid-phase proximity ligation assays (SP-PLA) requiring only 20 μL of samples, as a tool for discovering protein biomarkers for neurological disease and treatment thereof in cerebrospinal fluid (CSF). We applied the SP-PLA to samples from two sets of patients with poorly understood nervous system pathologies amyotrophic lateral sclerosis (ALS) and neuropathic pain, where patients were treated with spinal cord stimulation (SCS). Forty-seven inflammatory and neurotrophic proteins were measured in samples from 20 ALS patients and 15 neuropathic pain patients, and compared to normal concentrations in CSF from control individuals. Nineteen of the 47 proteins were detectable in more than 95% of the 72 controls. None of the 21 proteins detectable in CSF from neuropathic pain patients were significantly altered by SCS. The levels of the three proteins, follistatin, interleukin-1 alpha, and kallikrein-5 were all significantly reduced in the ALS group compared to age-matched controls. These results demonstrate the utility of purpose designed multiplex SP-PLA panels in CSF biomarker research for understanding neuropathological and neurotherapeutic mechanisms. The protein changes found in the CSF of ALS patients may be of diagnostic interest.

  • 132.
    Lind, Lars
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Syvänen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin.
    Axelsson, Tomas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin.
    Lundmark, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin.
    Hagg, S.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population2013Inngår i: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 208, nr 1, s. 88-94Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aim Indirect evidences by blockade of the endothelin receptors have suggested a role of endothelin in endothelium-dependent vasodilation. This study aimed to investigate whether circulating levels of endotehlin-1 or genetic variations in genes in the endothelin pathway were related to endothelium-dependent vasodilation. Methods In 1016 seventy-year-old participants of the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study (52% women), we measured endothelium-dependent vasodilation using the invasive forearm technique with acetylcholine given in the brachial artery (EDV) and the brachial artery ultrasound technique with measurement of flow-mediated dilatation (FMD). Plasma endothelin-1 levels were measured and 60 SNPs in genes in the endothelin pathway (ECE1, EDN1, EDNRA, EDNRB) were genotyped. Results No significant associations were found between circulating endothelin levels and EDV or FMD. No single genotype was related to EDV or FMD following adjustment for multiple testing, but a genotype score for 3 SNPs (rs11618266 in EDNRB, rs17675063 in EDNRA, rs3026868 in ECE1) was significantly related to EDV (beta coefficient 0.070, 95% CI 0.0250.12, P=0.002) when adjusting for gender, systolic blood pressure, HDL and LDL cholesterol, serum triglycerides, BMI, diabetes, smoking, antihypertensive medication or statins and CRP. This score was also related to nitroprusside-induced vasodilation in the forearm. Conclusion A combination of genotypes in the endothelin pathway was related to both endothelium-dependent and endothelium-independent vasodilation in forearm resistance vessels, but not in the brachial artery in an elderly population, giving evidence for a role of the endothelin system in resistance vessel reactivity independent of major cardiovascular risk factors.

  • 133.
    Lindahl, Bertil
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR). Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.
    Eggers, Kai M
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).
    Venge, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    James, Stefan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).
    Evaluation of four sensitive troponin assays for risk assessment in acute coronary syndromes using a new clinically oriented approach for comparison of assays2013Inngår i: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, E-ISSN 1437-4331, Vol. 51, nr 9, s. 1859-1864Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background:

    Measurement of cardiac troponin T or I (cTnT; cTnI) is useful for risk prediction in acute coronary syndromes. The objective of the present study was to compare the prognostic capacity of four sensitive cardiac troponin assays using a new method for comparison.

    Methods:

    Cardiac troponin was analyzed in serum samples from 1335 patients with acute coronary syndrome using the Elecsys high sensitivity TnT (hs-cTnT), ARCHITECT STAT high sensitivity TnI (hs-cTnI), Access AccuTnI (Acc-cTnI) and Architect cTnI (Arc-cTnI) assays. All patients were followed for 30 days regarding death and acute myocardial infarction (AMI), and for 1 year regarding mortality.

    Results:

    By receiver operating characteristic (ROC) curve analyses, there were only minor differences in the area under the curves (AUC) between the assays. At a given sensitivity of 85% the hs-cTnT, Arc-cTnI and Acc-cTnI assays showed comparable specificities, while 90% or higher sensitivity was only possible to achieve with the hs-cTnT, hs-cTnI and Acc-cTnI assays. The highest odds ratios for death/AMI at 30 days and death at 1 year, respectively, were reached by cut-off levels yielding 95% sensitivity; these cut-off levels were below the respective 99th percentile levels.

    Conclusions:

    By the adoption of a new method for the comparison of cardiac troponin assays we showed that the hs-cTnT, hs-cTnI and Acc-cTnI assays had comparable prognostic properties, while the Arc-cTnI assay had inferior prognostic sensitivity.

  • 134.
    Löf, Liza
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Arngården, Linda
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Olsson-Strömberg, Ulla
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Hematologi.
    Siart, Benjamin
    Jansson, Mattias
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Dahlin, Joakim S
    Thörn, Ingrid
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk och experimentell patologi.
    Christiansson, Lisa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Hermansson, Monica
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Ahlstrand, Erik
    Wålinder, Göran
    Söderberg, Ola
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Rosenquist, Richard
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Landegren, Ulf
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg.
    Kamali-Moghaddam, Masood
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia2017Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, s. 1-9, artikkel-id 623Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Chronic myeloid leukemia (CML) is characterized in the majority of cases by a t(9;22)(q34;q11) translocation, also called the Philadelphia chromosome, giving rise to the BCR-ABL1 fusion protein. Current treatment with tyrosine kinase inhibitors is directed against the constitutively active ABL1 domain of the fusion protein, and minimal residual disease (MRD) after therapy is monitored by real-time quantitative PCR (RQ-PCR) of the fusion transcript. Here, we describe a novel approach to detect and enumerate cells positive for the BCR-ABL1 fusion protein by combining the in situ proximity ligation assay with flow cytometry as readout (PLA-flow). By targeting of the BCR and ABL1 parts of the fusion protein with one antibody each, and creating strong fluorescent signals through rolling circle amplification, PLA-flow allowed sensitive detection of cells positive for the BCR-ABL1 fusion at frequencies as low as one in 10,000. Importantly, the flow cytometric results correlated strongly to those of RQ-PCR, both in diagnostic testing and for MRD measurements over time. In summary, we believe this flow cytometry-based method can serve as an attractive approach for routine measurement of cells harboring BCR-ABL1 fusions, also allowing simultaneously assessment of other cell surface markers as well as sensitive longitudinal follow-up.

  • 135.
    Löf, Liza
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Ebai, Tonge
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Dubois, Louise
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Wik, Lotta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Ronquist, K. Göran
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Nolander, Olivia
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Lundin, Emma
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Söderberg, Ola
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Landegren, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Kamali-Moghaddam, Masood
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Detecting individual extracellular vesicles using a multicolor in situ proximity ligation assay with flow cytometric readout2016Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, artikkel-id 34358Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Flow cytometry is a powerful method for quantitative and qualitative analysis of individual cells. However, flow cytometric analysis of extracellular vesicles (EVs), and the proteins present on their surfaces has been hampered by the small size of the EVs - in particular for the smallest EVs, which can be as little as 40 nm in diameter, the limited number of antigens present, and their low refractive index. We addressed these limitations for detection and characterization of EV by flow cytometry through the use of multiplex and multicolor in situ proximity ligation assays (in situ PLA), allowing each detected EV to be easily recorded over background noise using a conventional flow cytometer. By targeting sets of proteins on the surface that are specific for distinct classes of EVs, the method allows for selective recognition of populations of EVs in samples containing more than one type of EVs. The method presented herein opens up for analyses of EVs using flow cytometry for their characterization and quantification.

  • 136.
    Mahajan, Anubha
    et al.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England.
    Rodan, Aylin R.
    Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75229 USA.
    Le, Thu H.
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
    Gaulton, Kyle J.
    Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
    Haessler, Jeffrey
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
    Stilp, Adrienne M.
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
    Kamatani, Yoichiro
    Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
    Zhu, Gu
    Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
    Sofer, Tamar
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
    Puri, Sanjana
    Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75229 USA.
    Schellinger, Jeffrey N.
    Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75229 USA.
    Chu, Pei-Lun
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
    Cechova, Sylvia
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
    van Zuydam, Natalie
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England.
    Ärnlöv, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi. School of Health and Social Studies, Dalarna University, Falun 791 88, Sweden.
    Flessner, Michael F.
    National Institute of Diabetes, Digestive, and Kidney Disease, NIH, Bethesda, MD 20892, USA.
    Giedraitis, Vilmantas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Heath, Andrew C.
    Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA.
    Kubo, Michiaki
    Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Lindgren, Cecilia M.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7BN, UK.
    Madden, Pamela A. F.
    Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA.
    Montgomery, Grant W.
    Molecular Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
    Papanicolaou, George J.
    Epidemiology Branch, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
    Reiner, Alex P.
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Thornton, Timothy A.
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Ingelsson, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
    Cai, Jianwen
    Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
    Martin, Nicholas G.
    Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
    Kooperberg, Charles
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
    Matsuda, Koichi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
    Whitfield, John B.
    Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
    Okada, Yukinori
    Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
    Laurie, Cathy C.
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
    Morris, Andrew P.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
    Franceschini, Nora
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA.
    Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity2016Inngår i: American Journal of Human Genetics, ISSN 0002-9297, E-ISSN 1537-6605, Vol. 99, nr 3, s. 636-646Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We analyzed genome-wide association studies (GWASs), including data from 71,638 individuals from four ancestries, for estimated glomerular filtration rate (eGFR), a measure of kidney function used to define chronic kidney disease (CKD). We identified 20 loci attaining genome-wide-significant evidence of association (p < 5 × 10(-8)) with kidney function and highlighted that allelic effects on eGFR at lead SNPs are homogeneous across ancestries. We leveraged differences in the pattern of linkage disequilibrium between diverse populations to fine-map the 20 loci through construction of "credible sets" of variants driving eGFR association signals. Credible variants at the 20 eGFR loci were enriched for DNase I hypersensitivity sites (DHSs) in human kidney cells. DHS credible variants were expression quantitative trait loci for NFATC1 and RGS14 (at the SLC34A1 locus) in multiple tissues. Loss-of-function mutations in ancestral orthologs of both genes in Drosophila melanogaster were associated with altered sensitivity to salt stress. Renal mRNA expression of Nfatc1 and Rgs14 in a salt-sensitive mouse model was also reduced after exposure to a high-salt diet or induced CKD. Our study (1) demonstrates the utility of trans-ethnic fine mapping through integration of GWASs involving diverse populations with genomic annotation from relevant tissues to define molecular mechanisms by which association signals exert their effect and (2) suggests that salt sensitivity might be an important marker for biological processes that affect kidney function and CKD in humans.

  • 137. Mandic-Havelka, Aleksandra
    et al.
    Nilsen, Tom
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Sunde, Kathrin
    Norell, Maria
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Hansson, Lars O
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Turbidimetric Determination of Fecal Calprotectin Using Two Table Top Chemistry Analyzers: Mindray BS-200E and Cobas® c1112017Inngår i: Clinical Laboratory, ISSN 1433-6510, Vol. 63, nr 5, s. 907-913Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Fecal calprotectin assays are widely used in diagnosis and monitoring of inflammatory bowel disease (IBD) in patients with suspected IBD. The most frequently used technique is ELISA and microtiter plates. Turbidimetric assays for analysis of fecal calprotectin can significantly reduce turnaround time. Many laboratories may be reluctant to run fecal samples on their large chemistry analyzers. The aim of this study was to evaluate fecal calprotectin particle enhanced turbidimetric immunoassay (PETIA) on smaller chemistry analyzers that could be dedicated for fecal samples.

    METHODS: The BÜHLMANN fCAL® turbo assay was validated on two table top chemistry analyzers, Mindray BS-200E and cobas® c111.

    RESULTS: The assay was linear in the range between 20 and 1,900 µg/g with a limit of quantification around 20 µg/g on both instruments. The total coefficient of variation was < 7% in the range between 50 and 1,300 µg/g on both instruments. No antigen excess hook effect was observed up to 18,000 µg/g on the Mindray BS-200E and up to 20,000 µg/g on cobas® c111. The BÜHLMANN fCAL® turbo assay showed a high correlation with the BÜHLMANN fCAL® ELISA.

    CONCLUSIONS: Running the BÜHLMANN fCAL® turbo on Mindray BS-200E or cobas® c111 chemistry analyzers can provide rapid test results without exposing large routine chemistry analyzers to stool samples.

  • 138.
    Manivel, Vivek Anand
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Sohrabian, Azita
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Wick, Marius C.
    Håkansson, Lena Douhan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Elshafie, Amir
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Rönnelid, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Anti-type II collagen immune complex-induced granulocyte reactivity is associated with joint erosions in ra patients with anti-collagen antibodies2014Inngår i: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 73, nr S1, s. A5-A5Artikkel i tidsskrift (Annet vitenskapelig)
  • 139.
    Manivel, Vivek Anand
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Sohrabian, Azita
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Wick, Marius C.
    Mullazehi, Mohammed
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    Håkansson, Lena Douhan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Rönnelid, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Anti-type II collagen immune complex-induced granulocyte reactivity is associated with joint erosions in RA patients with anti-collagen antibodies2015Inngår i: Arthritis Research & Therapy, ISSN 1478-6354, E-ISSN 1478-6362, Vol. 17, artikkel-id 8Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction: Rheumatoid arthritis (RA) patients with autoantibodies against collagen type II (CII) are characterized by acute RA onset with elevated inflammatory measures and early joint erosions as well as increased production of tumor necrosis factor-alpha (TNF-alpha) by peripheral blood mononuclear cells (PBMC) stimulated by anti-CII immune complexes (IC) in vitro. Polymorphonuclear granulocytes (PMN) are abundant in RA synovial fluids, where they might interact directly with anti-CII IC in the articular cartilage, but no studies have investigated PMN responses towards anti-CII IC. The aim was to investigate whether PMN react towards anti-CII IC, and to what extent such reactivity might relate to the clinical acute onset RA phenotype associated with elevated levels of anti-CII. Methods: PMN and PBMC isolated from healthy donors were stimulated with IC made with a set of 72 baseline patient sera (24 anti-CII positive, 48 anti-CII negative) chosen from a clinically well-characterized RA cohort with two-year radiological follow-up with Larsen scoring. PMN expression of cluster of differentiation (CD) 11b, CD66b, CD16 and CD32 was measured by flow cytometry, whereas PMN production of myeloperoxidase (MPO) and interleukin (IL)-17, and PBMC production of TNF-alpha was measured with enzyme linked immunosorbent assay. Results: PMN expression of CD11b, CD66b and MPO, and PBMC production of TNF-alpha were upregulated whereas PMN expression of CD16 and CD32 were downregulated by anti-CII IC. CD16, CD66b, and MPO production correlated to serum anti-CII levels (Spearman's rho = 0.315, 0.675 and 0.253, respectively). CD16 was associated with early joint erosions (P = 0.024, 0.034, 0.046 at baseline, one and two years) and CD66b was associated with changes in joint erosions (P = 0.017 and 0.016, at one and two years compared to baseline, respectively). CD66b was associated with baseline C-reactive protein and PBMC production of TNF-alpha was associated with baseline erythrocyte sedimentation rate, in accordance with our earlier findings. No clinical associations were observed for MPO or IL-17. Conclusion: PMN responses against anti-CII IC are more closely associated with early joint erosions than are PBMC cytokine responses. PMN reactivity against anti-CII IC may contribute to joint destruction in newly diagnosed RA patients with high levels of anti-CII.

  • 140.
    Manivel, Vivek Anand
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Sohrabian, Azita
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Wick, Maurius C.
    Håkansson, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Rönnelid, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Granulocyte Reactivity is Associated with Cartilage Destruction in Patients with Anti-collagen Antibodies2014Inngår i: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 79, nr 6, s. 424-424Artikkel i tidsskrift (Annet vitenskapelig)
  • 141.
    Martensson, J.
    et al.
    Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.;Karolinska Inst, Sect Anesthesia & Intens Care Med, Dept Physiol & Pharmacol, Stockholm, Sweden..
    Glassford, N. J.
    Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.;Monash Univ, Sch Prevent Med & Publ Hlth, Australian & New Zealand Intens Care Res Ctr, Melbourne, Vic 3004, Australia..
    Jones, S.
    Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia..
    Eastwood, G. M.
    Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.;Deakin Univ, Sch Nursing & Midwifery, Melbourne, Vic 3004, Australia..
    Young, H.
    Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia..
    Peck, L.
    Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia..
    Ostland, V.
    Intrins LifeSci LLC, La Jolla, CA USA..
    Westerman, M.
    Intrins LifeSci LLC, La Jolla, CA USA..
    Venge, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Bellomo, R.
    Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.;Monash Univ, Sch Prevent Med & Publ Hlth, Australian & New Zealand Intens Care Res Ctr, Melbourne, Vic 3004, Australia..
    Urinary neutrophil gelatinase-associated lipocalin to hepcidin ratio as a biomarker of acute kidney injury in intensive care unit patients2015Inngår i: Minerva Anestesiologica, ISSN 0375-9393, E-ISSN 1827-1596, Vol. 81, nr 11, s. 1192-1200Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background. Labile iron is important in the pathogenesis of acute kidney injury (AKI). Neutrophil gelatinase-associated lipocalin (NGAL) and hepcidin control iron metabolism and are upregulated during renal stress. However, higher levels of urinary NGAL are associated with AKI severity whereas higher urinary hepcidin levels are associated with absence of AKI. We aimed to investigate the value of combining both biomarkers to estimate the severity and progression of AKI in intensive care unit (ICU) patients. Methods. Urinary NGAL and hepcidin were quantified within 48 hours of ICU admission in patients with the systemic inflammatory response syndrome and early kidney dysfunction (oliguria for >= 2 hours and/or a 25 mu mol/L creatinine rise from baseline). Diagnostic and prognostic characteristics were assessed by logistic regression and receiver operating characteristics (ROC) analysis. Results. Of 102 patients, 26 had mild AKI and 28 patients had severe AKI on admission. Sepsis (21%), cardiac surgery (17%) and liver failure (9%) were primary admission diagnoses. NGAL increased (P=0.03) whereas hepcidin decreased (P=0.01) with increasing AKI severity. The value of NGAL/hepcidin ratio to detect severe AKI was higher than when NGAL and hepcidin were used individually and persisted after adjusting for potential confounders (adjusted OR 2.40, 95% CI 1.20-4.78). The ROC areas for predicting worsening AKI were 0.50, 0.52 and 0.48 for NGAL, 1/hepcidin and the NGAL/hepcidin ratio. Conclusion. The NGAL/hepcidin ratio is more strongly associated with severe AKI than the single biomarkers alone. NGAL and hepcidin, alone or combined as a ratio, were unable to predict progressive AKI in this selected ICU cohort.

  • 142. Martensson, Johan
    et al.
    Bell, Max
    Xu, Shengyuan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Bottai, Matteo
    Ravn, Bo
    Venge, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Martling, Claes-Roland
    Association of plasma neutrophil gelatinase-associated lipocalin (NGAL) with sepsis and acute kidney dysfunction2013Inngår i: Biomarkers, ISSN 1354-750X, E-ISSN 1366-5804, Vol. 18, nr 4, s. 349-356Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: Neutrophil gelatinase-associated lipocalin (NGAL) is secreted by injured kidney cells as well as by activated neutrophils in response to bacterial infections. We assessed the influence of acute renal dysfunction on the association between plasma NGAL and sepsis. Methods: NGAL was measured daily in 138 critically ill patients. Simultaneous recordings of sepsis status and fluctuations in renal function were made. Results: Elevated NGAL was associated with sepsis independent of level of acute renal dysfunction. A cut-off value of 98 ng/mL distinguished sepsis from systemic inflammation with high sensitivity (0.77) and specificity (0.79). Conclusions: Plasma NGAL can help clinicians to identify bacterial infections in critically ill patients.

  • 143. Martensson, Johan
    et al.
    Xu, Shengyuan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Bell, Max
    Martling, Claes-Roland
    Venge, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Immunoassays distinguishing between HNL/NGAL released in urine from kidney epithelial cells and neutrophils2012Inngår i: Clinica Chimica Acta, ISSN 0009-8981, E-ISSN 1873-3492, Vol. 413, nr 19-20, s. 1661-1667Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The distinction between monomeric human neutrophil lipocalin/neutrophil gelatinase-associated lipocalin (HNL/NGAL), secreted by injured kidney tubular cells, and dimeric HNL/NGAL, released by activated neutrophils, is important to accurately diagnose acute kidney injury (AKI).

    Methods: 132 urine samples from 44 intensive care unit (ICU) patients and five urine samples from non-ICU patients with urinary tract infections (UTIs) were analyzed by two monoclonal enzyme-linked immunosorbent assays (ELISA-1 and ELISA-2). The presence of monomeric and/or dimeric HNL/NGAL in each sample was visualized by Western blotting.

    Results: The ELISA-1 detected both monomeric and dimeric HNL/NGAL whereas the ELISA-2 almost exclusively detected dimeric HNL/NGAL with an area under the receiver-operating characteristics curve (AuROC) of 0.90. The ELISA-1/ELISA-2 ratio detected the monomeric form with an AuROC of 0.92. In 32 AKI patients, dimer-specific EUSA-2 levels decreased pre-AKI whereas the monomer-specific ELISA-1/ELISA-2 ratio gradually increased beyond AKI diagnosis. High EUSA-2 levels and/or low ELISA-1/ELISA-2 ratios detected a predominance of dimeric HNL/NGAL in urine from the patients with tills.

    Conclusions: In combination, our two ELISAs distinguish monomeric HNL/NGAL, produced by the kidney epithelium, from dimeric HNL/NGAL, released by neutrophils during AKI development, as well as reduce the confounding effect of neutrophil involvement when bacteriuria is present.

  • 144. Mascialino, B.
    et al.
    Hermansson, L. L.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Ruling Out IBD In The United Kingdom And Brazil: Is The Usage Of F-Calprotectin In Primary Care Cost-Effective?2013Inngår i: Value in Health, ISSN 1098-3015, E-ISSN 1524-4733, Vol. 16, nr 7, s. A692-A692Artikkel i tidsskrift (Annet vitenskapelig)
  • 145. Mascialino, B.
    et al.
    Hermansson, L. L.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Ruling Out IBD In The United Kingdom And Spain: Is The Usage Of F-Calprotectin In Primary Care Cost-Effective?2013Inngår i: Value in Health, ISSN 1098-3015, E-ISSN 1524-4733, Vol. 16, nr 7, s. A493-A493Artikkel i tidsskrift (Annet vitenskapelig)
  • 146.
    Melki, Vilyam
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.
    Håkansson, Lena Douhan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Borowiec, Jan W.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Thoraxkirurgi.
    Effect of simulated extracorporeal circulation and glyceryl-tri-nitrate on leukocyte activation.2014Inngår i: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 48, nr 1, s. 59-64Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives. During extracorporeal circulation (ECC), a mechanical pump and an oxygenator replace the functions of the heart and lungs. The aim of this study is to test the effect of the nitric oxide donor glyceryl-tri-nitrate on activation markers of the innate immune system during simulated ECC. Design. Whole blood concentrations of selected leukocyte adhesion molecules, complement system components and myeloperoxidase (MPO) were measured in an in vitro system of simulated ECC. Results. Simulated ECC stimulated the expression of monocyte LPS-receptor CD14 and C3b-receptor CD35. Glyceryl-tri-nitrate significantly reduced the expression of leukocyte Fcγ receptor CD32 over time, compared to control. Simulated ECC increased the concentrations of MPO, terminal complement complex, and complement component C3a. Addition of glyceryl-tri-nitrate did not significantly affect these changes. Conclusions. Simulated ECC induces the increased expression of some leukocyte markers. Glyceryl-tri-nitrate addition significantly reduces the expression of some leukocyte activation markers.

  • 147.
    Molnar, Maria
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Bergquist, Maria
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Wiklund, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Lennmyr, Fredrik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Hyperglycaemia increases S100β after short experimental cardiac arrest2014Inngår i: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 58, nr 1, s. 106-113Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND:

    Hyperglycaemia is associated with aggravated ischaemic brain injury. The main objective of this study was to investigate the effects on cerebral perfusion of 5 min of cardiac arrest during hyperglycaemia and normoglycaemia.

    METHODS:

    Twenty triple-breed pigs (weight: 22-29 kg) were randomised and clamped at blood glucose levels of 8.5-10 mM [high (H)] or 4-5.5 mM [normal (N)] and thereafter subjected to alternating current-induced 5 min-cardiac arrest followed by 8 min of cardiopulmonary resuscitation and direct current shock to restore spontaneous circulation.

    RESULTS:

    Haemodynamics, laser Doppler measurements and regional venous oxygen saturation (HbO2 ) were monitored, and biochemical markers in blood [S100β, interleukin (IL)-6 and tumour necrosis factor (TNF)] quantified throughout an observation period of 3 h. The haemodynamics and physiological measurements were similar in the two groups. S100β increased over the experiment in the H compared with the N group (P < 0.05). IL-6 and TNF levels increased across the experiment, but no differences were seen between the groups.

    CONCLUSIONS:

    The enhanced S100β response is compatible with increased cerebral injury by hyperglycaemic compared with normoglycaemic 5 min of cardiac arrest and resuscitation. The inflammatory cytokines were similar between groups.

  • 148. Murray, Christopher J L
    et al.
    Barber, Ryan M
    Foreman, Kyle J
    Ozgoren, Ayse Abbasoglu
    Abd-Allah, Foad
    Abera, Semaw F
    Aboyans, Victor
    Abraham, Jerry P
    Abubakar, Ibrahim
    Abu-Raddad, Laith J
    Abu-Rmeileh, Niveen M
    Achoki, Tom
    Ackerman, Ilana N
    Ademi, Zanfina
    Adou, Arsène K
    Adsuar, José C
    Afshin, Ashkan
    Agardh, Emilie E
    Alam, Sayed Saidul
    Alasfoor, Deena
    Albittar, Mohammed I
    Alegretti, Miguel A
    Alemu, Zewdie A
    Alfonso-Cristancho, Rafael
    Alhabib, Samia
    Ali, Raghib
    Alla, François
    Allebeck, Peter
    Almazroa, Mohammad A
    Alsharif, Ubai
    Alvarez, Elena
    Alvis-Guzman, Nelson
    Amare, Azmeraw T
    Ameh, Emmanuel A
    Amini, Heresh
    Ammar, Walid
    Anderson, H Ross
    Anderson, Benjamin O
    Antonio, Carl Abelardo T
    Anwari, Palwasha
    Ärnlöv, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Arsenijevic, Valentina S Arsic
    Artaman, Al
    Asghar, Rana J
    Assadi, Reza
    Atkins, Lydia S
    Avila, Marco A
    Awuah, Baffour
    Bachman, Victoria F
    Badawi, Alaa
    Bahit, Maria C
    Balakrishnan, Kalpana
    Banerjee, Amitava
    Barker-Collo, Suzanne L
    Barquera, Simon
    Barregard, Lars
    Barrero, Lope H
    Basu, Arindam
    Basu, Sanjay
    Basulaiman, Mohammed O
    Beardsley, Justin
    Bedi, Neeraj
    Beghi, Ettore
    Bekele, Tolesa
    Bell, Michelle L
    Benjet, Corina
    Bennett, Derrick A
    Bensenor, Isabela M
    Benzian, Habib
    Bernabé, Eduardo
    Bertozzi-Villa, Amelia
    Beyene, Tariku J
    Bhala, Neeraj
    Bhalla, Ashish
    Bhutta, Zulfiqar A
    Bienhoff, Kelly
    Bikbov, Boris
    Biryukov, Stan
    Blore, Jed D
    Blosser, Christopher D
    Blyth, Fiona M
    Bohensky, Megan A
    Bolliger, Ian W
    Başara, Berrak Bora
    Bornstein, Natan M
    Bose, Dipan
    Boufous, Soufiane
    Bourne, Rupert R A
    Boyers, Lindsay N
    Brainin, Michael
    Brayne, Carol E
    Brazinova, Alexandra
    Breitborde, Nicholas J K
    Brenner, Hermann
    Briggs, Adam D
    Brooks, Peter M
    Brown, Jonathan C
    Brugha, Traolach S
    Buchbinder, Rachelle
    Buckle, Geoffrey C
    Budke, Christine M
    Bulchis, Anne
    Bulloch, Andrew G
    Campos-Nonato, Ismael R
    Carabin, Hélène
    Carapetis, Jonathan R
    Cárdenas, Rosario
    Carpenter, David O
    Caso, Valeria
    Castañeda-Orjuela, Carlos A
    Castro, Ruben E
    Catalá-López, Ferrán
    Cavalleri, Fiorella
    Çavlin, Alanur
    Chadha, Vineet K
    Chang, Jung-Chen
    Charlson, Fiona J
    Chen, Honglei
    Chen, Wanqing
    Chiang, Peggy P
    Chimed-Ochir, Odgerel
    Chowdhury, Rajiv
    Christensen, Hanne
    Christophi, Costas A
    Cirillo, Massimo
    Coates, Matthew M
    Coffeng, Luc E
    Coggeshall, Megan S
    Colistro, Valentina
    Colquhoun, Samantha M
    Cooke, Graham S
    Cooper, Cyrus
    Cooper, Leslie T
    Coppola, Luis M
    Cortinovis, Monica
    Criqui, Michael H
    Crump, John A
    Cuevas-Nasu, Lucia
    Danawi, Hadi
    Dandona, Lalit
    Dandona, Rakhi
    Dansereau, Emily
    Dargan, Paul I
    Davey, Gail
    Davis, Adrian
    Davitoiu, Dragos V
    Dayama, Anand
    De Leo, Diego
    Degenhardt, Louisa
    Del Pozo-Cruz, Borja
    Dellavalle, Robert P
    Deribe, Kebede
    Derrett, Sarah
    Jarlais, Don C Des
    Dessalegn, Muluken
    Dharmaratne, Samath D
    Dherani, Mukesh K
    Diaz-Torné, Cesar
    Dicker, Daniel
    Ding, Eric L
    Dokova, Klara
    Dorsey, E Ray
    Driscoll, Tim R
    Duan, Leilei
    Duber, Herbert C
    Ebel, Beth E
    Edmond, Karen M
    Elshrek, Yousef M
    Endres, Matthias
    Ermakov, Sergey P
    Erskine, Holly E
    Eshrati, Babak
    Esteghamati, Alireza
    Estep, Kara
    Faraon, Emerito Jose A
    Farzadfar, Farshad
    Fay, Derek F
    Feigin, Valery L
    Felson, David T
    Fereshtehnejad, Seyed-Mohammad
    Fernandes, Jefferson G
    Ferrari, Alize J
    Fitzmaurice, Christina
    Flaxman, Abraham D
    Fleming, Thomas D
    Foigt, Nataliya
    Forouzanfar, Mohammad H
    Fowkes, F Gerry R
    Paleo, Urbano Fra
    Franklin, Richard C
    Fürst, Thomas
    Gabbe, Belinda
    Gaffikin, Lynne
    Gankpé, Fortuné G
    Geleijnse, Johanna M
    Gessner, Bradford D
    Gething, Peter
    Gibney, Katherine B
    Giroud, Maurice
    Giussani, Giorgia
    Dantes, Hector Gomez
    Gona, Philimon
    González-Medina, Diego
    Gosselin, Richard A
    Gotay, Carolyn C
    Goto, Atsushi
    Gouda, Hebe N
    Graetz, Nicholas
    Gugnani, Harish C
    Gupta, Rahul
    Gupta, Rajeev
    Gutiérrez, Reyna A
    Haagsma, Juanita
    Hafezi-Nejad, Nima
    Hagan, Holly
    Halasa, Yara A
    Hamadeh, Randah R
    Hamavid, Hannah
    Hammami, Mouhanad
    Hancock, Jamie
    Hankey, Graeme J
    Hansen, Gillian M
    Hao, Yuantao
    Harb, Hilda L
    Haro, Josep Maria
    Havmoeller, Rasmus
    Hay, Simon I
    Hay, Roderick J
    Heredia-Pi, Ileana B
    Heuton, Kyle R
    Heydarpour, Pouria
    Higashi, Hideki
    Hijar, Martha
    Hoek, Hans W
    Hoffman, Howard J
    Hosgood, H Dean
    Hossain, Mazeda
    Hotez, Peter J
    Hoy, Damian G
    Hsairi, Mohamed
    Hu, Guoqing
    Huang, Cheng
    Huang, John J
    Husseini, Abdullatif
    Huynh, Chantal
    Iannarone, Marissa L
    Iburg, Kim M
    Innos, Kaire
    Inoue, Manami
    Islami, Farhad
    Jacobsen, Kathryn H
    Jarvis, Deborah L
    Jassal, Simerjot K
    Jee, Sun Ha
    Jeemon, Panniyammakal
    Jensen, Paul N
    Jha, Vivekanand
    Jiang, Guohong
    Jiang, Ying
    Jonas, Jost B
    Juel, Knud
    Kan, Haidong
    Karch, André
    Karema, Corine K
    Karimkhani, Chante
    Karthikeyan, Ganesan
    Kassebaum, Nicholas J
    Kaul, Anil
    Kawakami, Norito
    Kazanjan, Konstantin
    Kemp, Andrew H
    Kengne, Andre P
    Keren, Andre
    Khader, Yousef S
    Khalifa, Shams Eldin A
    Khan, Ejaz A
    Khan, Gulfaraz
    Khang, Young-Ho
    Kieling, Christian
    Kim, Daniel
    Kim, Sungroul
    Kim, Yunjin
    Kinfu, Yohannes
    Kinge, Jonas M
    Kivipelto, Miia
    Knibbs, Luke D
    Knudsen, Ann Kristin
    Kokubo, Yoshihiro
    Kosen, Soewarta
    Krishnaswami, Sanjay
    Defo, Barthelemy Kuate
    Bicer, Burcu Kucuk
    Kuipers, Ernst J
    Kulkarni, Chanda
    Kulkarni, Veena S
    Kumar, G Anil
    Kyu, Hmwe H
    Lai, Taavi
    Lalloo, Ratilal
    Lallukka, Tea
    Lam, Hilton
    Lan, Qing
    Lansingh, Van C
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Lawrynowicz, Alicia E B
    Leasher, Janet L
    Leigh, James
    Leung, Ricky
    Levitz, Carly E
    Li, Bin
    Li, Yichong
    Li, Yongmei
    Lim, Stephen S
    Lind, Maggie
    Lipshultz, Steven E
    Liu, Shiwei
    Liu, Yang
    Lloyd, Belinda K
    Lofgren, Katherine T
    Logroscino, Giancarlo
    Looker, Katharine J
    Lortet-Tieulent, Joannie
    Lotufo, Paulo A
    Lozano, Rafael
    Lucas, Robyn M
    Lunevicius, Raimundas
    Lyons, Ronan A
    Ma, Stefan
    Macintyre, Michael F
    Mackay, Mark T
    Majdan, Marek
    Malekzadeh, Reza
    Marcenes, Wagner
    Margolis, David J
    Margono, Christopher
    Marzan, Melvin B
    Masci, Joseph R
    Mashal, Mohammad T
    Matzopoulos, Richard
    Mayosi, Bongani M
    Mazorodze, Tasara T
    Mcgill, Neil W
    Mcgrath, John J
    Mckee, Martin
    Mclain, Abigail
    Meaney, Peter A
    Medina, Catalina
    Mehndiratta, Man Mohan
    Mekonnen, Wubegzier
    Melaku, Yohannes A
    Meltzer, Michele
    Memish, Ziad A
    Mensah, George A
    Meretoja, Atte
    Mhimbira, Francis A
    Micha, Renata
    Miller, Ted R
    Mills, Edward J
    Mitchell, Philip B
    Mock, Charles N
    Ibrahim, Norlinah Mohamed
    Mohammad, Karzan A
    Mokdad, Ali H
    Mola, Glen L D
    Monasta, Lorenzo
    Hernandez, Julio C Montañez
    Montico, Marcella
    Montine, Thomas J
    Mooney, Meghan D
    Moore, Ami R
    Moradi-Lakeh, Maziar
    Moran, Andrew E
    Mori, Rintaro
    Moschandreas, Joanna
    Moturi, Wilkister N
    Moyer, Madeline L
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    Mukaigawara, Mitsuru
    Mullany, Erin C
    Murdoch, Michele E
    Murray, Joseph
    Murthy, Kinnari S
    Naghavi, Mohsen
    Naheed, Aliya
    Naidoo, Kovin S
    Naldi, Luigi
    Nand, Devina
    Nangia, Vinay
    Narayan, K M Venkat
    Nejjari, Chakib
    Neupane, Sudan P
    Newton, Charles R
    Ng, Marie
    Ngalesoni, Frida N
    Nguyen, Grant
    Nisar, Muhammad I
    Nolte, Sandra
    Norheim, Ole F
    Norman, Rosana E
    Norrving, Bo
    Nyakarahuka, Luke
    Oh, In-Hwan
    Ohkubo, Takayoshi
    Ohno, Summer L
    Olusanya, Bolajoko O
    Opio, John Nelson
    Ortblad, Katrina
    Ortiz, Alberto
    Pain, Amanda W
    Pandian, Jeyaraj D
    Panelo, Carlo Irwin A
    Papachristou, Christina
    Park, Eun-Kee
    Park, Jae-Hyun
    Patten, Scott B
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    Pavlin, Boris I
    Pearce, Neil
    Pereira, David M
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    Pervaiz, Aslam
    Pesudovs, Konrad
    Peterson, Carrie B
    Petzold, Max
    Phillips, Michael R
    Phillips, Bryan K
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    Piel, Frédéric B
    Plass, Dietrich
    Poenaru, Dan
    Polinder, Suzanne
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    Poulton, Richie G
    Pourmalek, Farshad
    Prabhakaran, Dorairaj
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    Qato, Dima M
    Quistberg, D Alex
    Rafay, Anwar
    Rahimi, Kazem
    Rahman, Sajjad U
    Raju, Murugesan
    Rana, Saleem M
    Razavi, Homie
    Reddy, K Srinath
    Refaat, Amany
    Remuzzi, Giuseppe
    Resnikoff, Serge
    Ribeiro, Antonio L
    Richardson, Lee
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    Roberts, D Allen
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    Ronfani, Luca
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    Roy, Nobhojit
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    Sandar, Logan
    Santos, Itamar S
    Satpathy, Maheswar
    Sawhney, Monika
    Scarborough, Peter
    Schneider, Ione J
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    Shangguan, Siyi
    She, Jun
    Sheikhbahaei, Sara
    Shi, Peilin
    Shibuya, Kenji
    Shinohara, Yukito
    Shiri, Rahman
    Shishani, Kawkab
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    Singh, Abhishek
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    Soneji, Samir
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    Stanaway, Jeffrey D
    Stathopoulou, Vasiliki
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    Steiner, Timothy J
    Stevens, Antony
    Stewart, Andrea
    Stovner, Lars J
    Stroumpoulis, Konstantinos
    Sunguya, Bruno F
    Swaminathan, Soumya
    Swaroop, Mamta
    Sykes, Bryan L
    Tabb, Karen M
    Takahashi, Ken
    Tandon, Nikhil
    Tanne, David
    Tanner, Marcel
    Tavakkoli, Mohammad
    Taylor, Hugh R
    Ao, Braden J Te
    Tediosi, Fabrizio
    Temesgen, Awoke M
    Templin, Tara
    Ten Have, Margreet
    Tenkorang, Eric Y
    Terkawi, Abdullah S
    Thomson, Blake
    Thorne-Lyman, Andrew L
    Thrift, Amanda G
    Thurston, George D
    Tillmann, Taavi
    Tonelli, Marcello
    Topouzis, Fotis
    Toyoshima, Hideaki
    Traebert, Jefferson
    Tran, Bach X
    Trillini, Matias
    Truelsen, Thomas
    Tsilimbaris, Miltiadis
    Tuzcu, Emin M
    Uchendu, Uche S
    Ukwaja, Kingsley N
    Undurraga, Eduardo A
    Uzun, Selen B
    Van Brakel, Wim H
    Van De Vijver, Steven
    van Gool, Coen H
    Van Os, Jim
    Vasankari, Tommi J
    Venketasubramanian, N
    Violante, Francesco S
    Vlassov, Vasiliy V
    Vollset, Stein Emil
    Wagner, Gregory R
    Wagner, Joseph
    Waller, Stephen G
    Wan, Xia
    Wang, Haidong
    Wang, Jianli
    Wang, Linhong
    Warouw, Tati S
    Weichenthal, Scott
    Weiderpass, Elisabete
    Weintraub, Robert G
    Wenzhi, Wang
    Werdecker, Andrea
    Westerman, Ronny
    Whiteford, Harvey A
    Wilkinson, James D
    Williams, Thomas N
    Wolfe, Charles D
    Wolock, Timothy M
    Woolf, Anthony D
    Wulf, Sarah
    Wurtz, Brittany
    Xu, Gelin
    Yan, Lijing L
    Yano, Yuichiro
    Ye, Pengpeng
    Yentür, Gökalp K
    Yip, Paul
    Yonemoto, Naohiro
    Yoon, Seok-Jun
    Younis, Mustafa Z
    Yu, Chuanhua
    Zaki, Maysaa E
    Zhao, Yong
    Zheng, Yingfeng
    Zonies, David
    Zou, Xiaonong
    Salomon, Joshua A
    Lopez, Alan D
    Vos, Theo
    Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition2015Inngår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 386, nr 10009, s. 2145-2191Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND:

    The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development.

    METHODS:

    We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time.

    FINDINGS:

    Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6-6·6), from 65·3 years (65·0-65·6) in 1990 to 71·5 years (71·0-71·9) in 2013, HALE at birth rose by 5·4 years (4·9-5·8), from 56·9 years (54·5-59·1) to 62·3 years (59·7-64·8), total DALYs fell by 3·6% (0·3-7·4), and age-standardised DALY rates per 100 000 people fell by 26·7% (24·6-29·1). For communicable, maternal, neonatal, and nutritional disorders, global DALY numbers, crude rates, and age-standardised rates have all declined between 1990 and 2013, whereas for non-communicable diseases, global DALYs have been increasing, DALY rates have remained nearly constant, and age-standardised DALY rates declined during the same period. From 2005 to 2013, the number of DALYs increased for most specific non-communicable diseases, including cardiovascular diseases and neoplasms, in addition to dengue, food-borne trematodes, and leishmaniasis; DALYs decreased for nearly all other causes. By 2013, the five leading causes of DALYs were ischaemic heart disease, lower respiratory infections, cerebrovascular disease, low back and neck pain, and road injuries. Sociodemographic status explained more than 50% of the variance between countries and over time for diarrhoea, lower respiratory infections, and other common infectious diseases; maternal disorders; neonatal disorders; nutritional deficiencies; other communicable, maternal, neonatal, and nutritional diseases; musculoskeletal disorders; and other non-communicable diseases. However, sociodemographic status explained less than 10% of the variance in DALY rates for cardiovascular diseases; chronic respiratory diseases; cirrhosis; diabetes, urogenital, blood, and endocrine diseases; unintentional injuries; and self-harm and interpersonal violence. Predictably, increased sociodemographic status was associated with a shift in burden from YLLs to YLDs, driven by declines in YLLs and increases in YLDs from musculoskeletal disorders, neurological disorders, and mental and substance use disorders. In most country-specific estimates, the increase in life expectancy was greater than that in HALE. Leading causes of DALYs are highly variable across countries.

    INTERPRETATION:

    Global health is improving. Population growth and ageing have driven up numbers of DALYs, but crude rates have remained relatively constant, showing that progress in health does not mean fewer demands on health systems. The notion of an epidemiological transition-in which increasing sociodemographic status brings structured change in disease burden-is useful, but there is tremendous variation in burden of disease that is not associated with sociodemographic status. This further underscores the need for country-specific assessments of DALYs and HALE to appropriately inform health policy decisions and attendant actions.

    FUNDING:

    Bill & Melinda Gates Foundation.

  • 149. Murray, Christopher J L
    et al.
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    Amini, Hassan
    Ammar, Walid
    Anderson, Benjamin O
    Antonio, Carl Abelardo T
    Anwari, Palwasha
    Ärnlöv, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi.
    Arsenijevic, Valentina S Arsic
    Artaman, Ali
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    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
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    Terkawi, Abdullah Sulieman
    Thomson, Alan J
    Thorne-Lyman, Andrew L
    Towbin, Jeffrey A
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    Tran, Bach X
    Dimbuene, Zacharie Tsala
    Tsilimbaris, Miltiadis
    Uchendu, Uche S
    Ukwaja, Kingsley N
    Vallely, Andrew J
    Vasankari, Tommi J
    Venketasubramanian, N
    Violante, Francesco S
    Vlassov, Vasiliy Victorovich
    Waller, Stephen
    Wallin, Mitchell T
    Wang, Linhong
    Wang, Sharon Xiaorong
    Wang, Yanping
    Weichenthal, Scott
    Weiderpass, Elisabete
    Weintraub, Robert G
    Westerman, Ronny
    White, Richard A
    Wilkinson, James D
    Williams, Thomas Neil
    Woldeyohannes, Solomon Meseret
    Wong, John Q
    Xu, Gelin
    Yang, Yang C
    Yano, Yuichiro
    Yip, Paul
    Yonemoto, Naohiro
    Yoon, Seok-Jun
    Younis, Mustafa
    Yu, Chuanhua
    Jin, Kim Yun
    El Sayed Zaki, Maysaa
    Zhao, Yong
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    Zhou, Maigeng
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    Zou, Xiao Nong
    Lopez, Alan D
    Vos, Theo
    Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 20132014Inngår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, nr 9947, s. 1005-1070Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study provides a consistent and comprehensive approach to disease estimation for between 1990 and 2013, and an opportunity to assess whether accelerated progress has occured since the Millennium Declaration.

    METHODS: To estimate incidence and mortality for HIV, we used the UNAIDS Spectrum model appropriately modified based on a systematic review of available studies of mortality with and without antiretroviral therapy (ART). For concentrated epidemics, we calibrated Spectrum models to fit vital registration data corrected for misclassification of HIV deaths. In generalised epidemics, we minimised a loss function to select epidemic curves most consistent with prevalence data and demographic data for all-cause mortality. We analysed counterfactual scenarios for HIV to assess years of life saved through prevention of mother-to-child transmission (PMTCT) and ART. For tuberculosis, we analysed vital registration and verbal autopsy data to estimate mortality using cause of death ensemble modelling. We analysed data for corrected case-notifications, expert opinions on the case-detection rate, prevalence surveys, and estimated cause-specific mortality using Bayesian meta-regression to generate consistent trends in all parameters. We analysed malaria mortality and incidence using an updated cause of death database, a systematic analysis of verbal autopsy validation studies for malaria, and recent studies (2010-13) of incidence, drug resistance, and coverage of insecticide-treated bednets.

    FINDINGS: Globally in 2013, there were 1·8 million new HIV infections (95% uncertainty interval 1·7 million to 2·1 million), 29·2 million prevalent HIV cases (28·1 to 31·7), and 1·3 million HIV deaths (1·3 to 1·5). At the peak of the epidemic in 2005, HIV caused 1·7 million deaths (1·6 million to 1·9 million). Concentrated epidemics in Latin America and eastern Europe are substantially smaller than previously estimated. Through interventions including PMTCT and ART, 19·1 million life-years (16·6 million to 21·5 million) have been saved, 70·3% (65·4 to 76·1) in developing countries. From 2000 to 2011, the ratio of development assistance for health for HIV to years of life saved through intervention was US$4498 in developing countries. Including in HIV-positive individuals, all-form tuberculosis incidence was 7·5 million (7·4 million to 7·7 million), prevalence was 11·9 million (11·6 million to 12·2 million), and number of deaths was 1·4 million (1·3 million to 1·5 million) in 2013. In the same year and in only individuals who were HIV-negative, all-form tuberculosis incidence was 7·1 million (6·9 million to 7·3 million), prevalence was 11·2 million (10·8 million to 11·6 million), and number of deaths was 1·3 million (1·2 million to 1·4 million). Annualised rates of change (ARC) for incidence, prevalence, and death became negative after 2000. Tuberculosis in HIV-negative individuals disproportionately occurs in men and boys (versus women and girls); 64·0% of cases (63·6 to 64·3) and 64·7% of deaths (60·8 to 70·3). Globally, malaria cases and deaths grew rapidly from 1990 reaching a peak of 232 million cases (143 million to 387 million) in 2003 and 1·2 million deaths (1·1 million to 1·4 million) in 2004. Since 2004, child deaths from malaria in sub-Saharan Africa have decreased by 31·5% (15·7 to 44·1). Outside of Africa, malaria mortality has been steadily decreasing since 1990.

    INTERPRETATION: Our estimates of the number of people living with HIV are 18·7% smaller than UNAIDS's estimates in 2012. The number of people living with malaria is larger than estimated by WHO. The number of people living with HIV, tuberculosis, or malaria have all decreased since 2000. At the global level, upward trends for malaria and HIV deaths have been reversed and declines in tuberculosis deaths have accelerated. 101 countries (74 of which are developing) still have increasing HIV incidence. Substantial progress since the Millennium Declaration is an encouraging sign of the effect of global action.

  • 150.
    Mårtensson, Johan
    et al.
    Karolinska Institutet, Stockholm.
    Jonsson, Niklas
    Karolinska Institutet, Stockholm.
    Glassford, Neil J
    Austin Hospital, Australien.
    Bell, Max
    Karolinska Institutet, Stockholm.
    Martling, Claes-Roland
    Karolinska Institutet, Stockholm.
    Bellomo, Rinaldo
    Austin Hospital, Australien.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Plasma endostatin may improve acute kidney injury risk prediction in critically ill patients2016Inngår i: Annals of Intensive Care, ISSN 2110-5820, E-ISSN 2110-5820, Vol. 6, artikkel-id 6Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Breakdown of renal endothelial, tubular and glomerular matrix collagen plays a major role in acute kidney injury (AKI) development. Such collagen breakdown releases endostatin into the circulation. The aim of this study was to compare the AKI predictive value of plasma endostatin with two previously suggested biomarkers of AKI, cystatin C and neutrophil gelatinase-associated lipocalin (NGAL).

    METHODS: We studied 93 patients without kidney disease who had a first plasma sample obtained within 48 h of ICU admission. We identified risk factors for AKI within the population and designed a predictive model. The individual ability and net contribution of endostatin, cystatin C and NGAL to predict AKI were evaluated by the area under the receiver operating characteristics curve (AUC), likelihood-ratio test, net reclassification improvement (NRI) and integrated discrimination improvement (IDI).

    RESULTS: In total, 21 (23 %) patients experienced AKI within 72 h. A three-parameter model (age, illness severity score and early oliguria) predicted AKI with an AUC of 0.759 (95 % CI 0.646-0.872). Adding endostatin to the predictive model significantly (P = 0.04) improved the AUC to 0.839 (95 % CI 0.752-0.925). In addition, endostatin significantly improved risk prediction using the likelihood-ratio test (P = 0.005), NRI analysis (0.27; P = 0.04) and IDI analysis (0.07; P = 0.04). In contrast, adding cystatin C or NGAL to the three-parameter model did not improve risk prediction in any of the four analyses.

    CONCLUSIONS: In this cohort of critically ill patients, plasma endostatin improved AKI prediction based on clinical risk factors, while cystatin C and NGAL did not.

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