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  • 101.
    Kisonaite, Konstancija
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Quantitative assessment of glaucoma by artificial intelligence estimation of the waist of the nerve fiber layer in the optic nerve head2023Licentiatavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Glaucoma is a chronic progressive disease that causes loss of retinal ganglion cells, which impairs the visual field. In optic coherence tomography (OCT) image, the retinal ganglion cell (RGC) axons in the optic nerve head (ONH) can be quantified as the minimal thickness from the ONH Pigmental epithelium Central Limit (OPCL) to the Inner limit of the Retina Closest Point (IRCP). Alternatively, the minimal cross-sectional surface area can be measured. In peripapillary atrophy, the morphometry of the retinal pigmental epithelium is affected.

    Purpose: To design and test a new computational algorithm for estimation of Pigment epithelium to Inner limit of the Retina Minimal Area (PIMA) and evaluate a new method to estimate the Pigment epithelium to Inner limit of the Retina Minimal Distance (PIMD). OPCL can be detected and annotated by a deep learning algorithm in individuals with peripapillary atrophy.

    Methods: A deep learning algorithm has been trained to automatically detect OPCL, IRCP and calculate PIMD. A new computational algorithm was developed to estimate PIMA in OCT images of young adults. The mean between the first and second version of estimating PIMD was evaluated. The difference of distance between the ONH center-OPCL and ONH center-atrophic edge was estimated in eyes with peripapillary atrophy.

    Results: A 95% confidence interval for PIMA-2π was estimated to 1.97 ± 0.19 mm2 (df = 15). A confidence interval for the difference between PIMDv1-2π and PIMDv2-2π was 0 ± 1 μm (df = 15). A 95 % confidence interval for the mean difference between ONH-OPCL and ONH-atrophic edge was estimated to 692 ± 192 µm (df = 5).

    Conclusions: The computational algorithm for estimation of PIMA was developed and applied. An initial analysis indicated the capacity of the deep learning algorithm to detect OPCL in subjects with PPA.

    Keywords: deep learning, optic nerve head, ONH, retinal pigmental epithelium, RPE, PIMD, PIMD-2π, minimal distance, PIMA, PIMA-2π, minimal area, peripapillary atrophy, PPA, optic coherence tomography, OCT, glaucoma, quantification, retinal ganglion cell axons

    Delarbeten
    1. Automatic estimation of the cross-sectional area of the waist of the nerve fiber layer at the optic nerve head
    Öppna denna publikation i ny flik eller fönster >>Automatic estimation of the cross-sectional area of the waist of the nerve fiber layer at the optic nerve head
    Visa övriga...
    2023 (Engelska)Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768Artikel i tidskrift (Refereegranskat) Epub ahead of print
    Abstract [en]

    Purpose

    Glaucoma leads to pathological loss of axons in the retinal nerve fibre layer at the optic nerve head (ONH). This study aimed to develop a strategy for the estimation of the cross-sectional area of the axons in the ONH. Furthermore, improving the estimation of the thickness of the nerve fibre layer, as compared to a method previously published by us.

    Methods

    In the 3D-OCT image of the ONH, the central limit of the pigment epithelium and the inner limit of the retina, respectively, were identified with deep learning algorithms. The minimal distance was estimated at equidistant angles around the circumference of the ONH. The cross-sectional area was estimated by the computational algorithm. The computational algorithm was applied on 16 non-glaucomatous subjects.

    Results

    The mean cross-sectional area of the waist of the nerve fibre layer in the ONH was 1.97 ± 0.19 mm2. The mean difference in minimal thickness of the waist of the nerve fibre layer between our previous and the current strategies was estimated as CIμ (0.95) 0 ± 1 μm (d.f. = 15).

    Conclusions

    The developed algorithm demonstrated an undulating cross-sectional area of the nerve fibre layer at the ONH. Compared to studies using radial scans, our algorithm resulted in slightly higher values for cross-sectional area, taking the undulations of the nerve fibre layer at the ONH into account. The new algorithm for estimation of the thickness of the waist of the nerve fibre layer in the ONH yielded estimates of the same order as our previous algorithm.

    Ort, förlag, år, upplaga, sidor
    John Wiley & Sons, 2023
    Nyckelord
    artificial intelligence, cross-sectional area, deep learning, minimal thickness, nerve fibre layer, optic nerve head, optical coherence tomography, surface area, waist
    Nationell ämneskategori
    Oftalmologi
    Forskningsämne
    Medicinsk vetenskap; Oftalmiatrik
    Identifikatorer
    urn:nbn:se:uu:diva-502039 (URN)10.1111/aos.15698 (DOI)
    Forskningsfinansiär
    ÖgonfondenStiftelsen Kronprinsessan Margaretas arbetsnämnd för synskadadeVinnova, 2017-02447Region Uppsala
    Tillgänglig från: 2023-05-19 Skapad: 2023-05-19 Senast uppdaterad: 2023-06-05Bibliografiskt granskad
    2. AI-based detection of the inner limit of the minimal waist of the nerve fiber bundles in the ONH in subjects with peripapillary atrophy
    Öppna denna publikation i ny flik eller fönster >>AI-based detection of the inner limit of the minimal waist of the nerve fiber bundles in the ONH in subjects with peripapillary atrophy
    (Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    Purpose: To verify that a deep learning model developed by our research group does not wrongly identify the outer edge of the atrophic zone in eyes with peripapillary atrophy (PPA) rather than a point adjacent to the external limit of the minimal waist of the nerve fiber bundles in the ONH.

    Methods: Subjects with at least one eye with PPA were included. The ONH of the eye with PPA was imaged with colour photography, and the three-dimensional structure of the ONH was captured three times at one occasion with SS-OCT (Topcon Triton, Japan). Each capture was exported to a custom-made software for analysis. The custom-made software, AutoPimd, allowed fully automatic localization of the external limit of the minimal waist of the nerve fiber layer in space using deep learning-model. An en face visualization of the frontal plane of the ONH and user measurement in the en face view is possible. The en face view in the OCT volume was verified to render PPA as imaged in the photograph. The distance between the ONH center and the extreme edge of the PPA was measured in the en face view of the OCT. Then, the frontal plane distance between the ONH center and the fully automatically detected external limit of the minimal waist of the nerve fiber layer in the ONH was measured along the same frontal plane angle.

    Results: A 95 % confidence interval for the mean difference between the distance from center of the ONH to the extreme edge of the PPA, and the distance from the center of the ONH to the corresponding fully automatically detected outer limit of the minimal waist of the nerve fiber layer was estimated to 692 ± 192 μm (d.f = 5).

    Conclusion: Our AI model does not wrongly localize the outer limit of PPA as the external limit of the minimal waist of the nerve fiber layer. The structural representation of the external limit of the minimal waist of the nerve fiber bundles localized by our fully automatic AI model in eyes with PPA remains to be identified.

    Nyckelord
    ONH, nerve fibers, minimal waist, OCT, artificial intelligence, deep learning, peripapillary atrophy
    Nationell ämneskategori
    Oftalmologi
    Forskningsämne
    Oftalmiatrik
    Identifikatorer
    urn:nbn:se:uu:diva-502040 (URN)
    Tillgänglig från: 2023-05-19 Skapad: 2023-05-19 Senast uppdaterad: 2023-06-05Bibliografiskt granskad
    Ladda ner fulltext (pdf)
    Quantitative assessment of glaucoma by artificial intelligence estimation of the waist of the nerve fiber layer in the optic nerve head
  • 102.
    Kisonaite, Konstancija
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.
    Yu, Zhaohua
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.
    Raeme, Faisal
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.
    Bendazzoli, Simone
    KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, Stockholm, Sweden..
    Wang, Chunliang
    KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, Stockholm, Sweden..
    Söderberg, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Estimation of the cross-sectional surface area of the waist of the nerve fiber layer at the optic nerve head2022Ingår i: OPHTHALMIC TECHNOLOGIES XXXII / [ed] Hammer, DX Joos, KM Palanker, DV, SPIE-Intl Soc Optical Eng SPIE - The International Society for Optics and Photonics, 2022, Vol. 11941, artikel-id 119410FKonferensbidrag (Refereegranskat)
    Abstract [en]

    Glaucoma is a global disease that leads to blindness due to pathological loss of retinal ganglion cell axons in the optic nerve head (ONH). The presented project aims at improving a computational algorithm for estimating the thickness and surface area of the waist of the nerve fiber layer in the ONH. Our currently developed deep learning AI algorithm meets the need for a morphometric parameter that detects glaucomatous change earlier than current clinical follow-up methods. In 3D OCT image volumes, two different AI algorithms identify the Optic nerve head Pigment epithelium Central Limit (OPCL) and the Inner limit of the Retina Closest Point (IRCP) in a 3D grid. Our computational algorithm includes the undulating surface area of the waist of the ONH, as well as waist thickness. In 16 eyes of 16 non-glaucomatous subjects aged [20;30] years, the mean difference in minimal thickness of the waist of the nerve fiber layer between our previous and the current post-processing strategies was estimated as CI mu(0.95) 0 +/- 1 mu m (D.f. 15). The mean surface area of the waist of the nerve fiber layer in the optic nerve head was 1.97 +/- 0.19 mm(2). Our computational algorithm results in slightly higher values for surface areas compared to published work, but as expected, this may be due to surface undulations of the waist being considered. Estimates of the thickness of the waist of the ONH yields estimates of the same order as our previous computational algorithm.

  • 103.
    Kisonaite, Konstancija
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Yu, Zhaohua
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Raeme, Faisal
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Bendazzoli, Simone
    Kungliga Tekniska Högskolan, Medicinsk avbildning.
    Wang, Chunliang
    Kungliga Tekniska Högskolan, Medicinsk avbildning.
    Söderberg, Per G.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Automatic estimation of the cross-sectional area of the waist of the nerve fiber layer at the optic nerve head2023Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose

    Glaucoma leads to pathological loss of axons in the retinal nerve fibre layer at the optic nerve head (ONH). This study aimed to develop a strategy for the estimation of the cross-sectional area of the axons in the ONH. Furthermore, improving the estimation of the thickness of the nerve fibre layer, as compared to a method previously published by us.

    Methods

    In the 3D-OCT image of the ONH, the central limit of the pigment epithelium and the inner limit of the retina, respectively, were identified with deep learning algorithms. The minimal distance was estimated at equidistant angles around the circumference of the ONH. The cross-sectional area was estimated by the computational algorithm. The computational algorithm was applied on 16 non-glaucomatous subjects.

    Results

    The mean cross-sectional area of the waist of the nerve fibre layer in the ONH was 1.97 ± 0.19 mm2. The mean difference in minimal thickness of the waist of the nerve fibre layer between our previous and the current strategies was estimated as CIμ (0.95) 0 ± 1 μm (d.f. = 15).

    Conclusions

    The developed algorithm demonstrated an undulating cross-sectional area of the nerve fibre layer at the ONH. Compared to studies using radial scans, our algorithm resulted in slightly higher values for cross-sectional area, taking the undulations of the nerve fibre layer at the ONH into account. The new algorithm for estimation of the thickness of the waist of the nerve fibre layer in the ONH yielded estimates of the same order as our previous algorithm.

    Ladda ner fulltext (pdf)
    fulltext
  • 104.
    Kisonaite, Konstancija
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Yu, Zhaohua
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Söderberg, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    AI-based detection of the inner limit of the minimal waist of the nerve fiber bundles in the ONH in subjects with peripapillary atrophyManuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    Purpose: To verify that a deep learning model developed by our research group does not wrongly identify the outer edge of the atrophic zone in eyes with peripapillary atrophy (PPA) rather than a point adjacent to the external limit of the minimal waist of the nerve fiber bundles in the ONH.

    Methods: Subjects with at least one eye with PPA were included. The ONH of the eye with PPA was imaged with colour photography, and the three-dimensional structure of the ONH was captured three times at one occasion with SS-OCT (Topcon Triton, Japan). Each capture was exported to a custom-made software for analysis. The custom-made software, AutoPimd, allowed fully automatic localization of the external limit of the minimal waist of the nerve fiber layer in space using deep learning-model. An en face visualization of the frontal plane of the ONH and user measurement in the en face view is possible. The en face view in the OCT volume was verified to render PPA as imaged in the photograph. The distance between the ONH center and the extreme edge of the PPA was measured in the en face view of the OCT. Then, the frontal plane distance between the ONH center and the fully automatically detected external limit of the minimal waist of the nerve fiber layer in the ONH was measured along the same frontal plane angle.

    Results: A 95 % confidence interval for the mean difference between the distance from center of the ONH to the extreme edge of the PPA, and the distance from the center of the ONH to the corresponding fully automatically detected outer limit of the minimal waist of the nerve fiber layer was estimated to 692 ± 192 μm (d.f = 5).

    Conclusion: Our AI model does not wrongly localize the outer limit of PPA as the external limit of the minimal waist of the nerve fiber layer. The structural representation of the external limit of the minimal waist of the nerve fiber bundles localized by our fully automatic AI model in eyes with PPA remains to be identified.

  • 105.
    Kronschlager, Martin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Talebizadeh, Nooshin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Yu, Zhaohua
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Meyer, Linda Maren
    Lofgren, Stefan
    Apoptosis in Rat Cornea After In Vivo Exposure to Ultraviolet Radiation at 300 nm2015Ingår i: Cornea, ISSN 0277-3740, E-ISSN 1536-4798, Vol. 34, nr 8, s. 945-949Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose:Peak toxicity for in vivo ultraviolet radiation (UVR) exposure to the lens is in the 300-nm wavelength region. However, little is known about corneal cell damage at 300 nm. The purpose of the study was to determine the time evolution of apoptosis in the cornea after in vivo exposure to 300-nm UVR.Methods:Altogether, 16 Sprague Dawley rats were divided into 4 groups and unilaterally exposed to 5 kJ/m(2) UVR ((max): 300 nm; (0.5): 10 nm) for 15 minutes. After a predetermined latency period of 1, 5, 24, and 120 hours, depending on the group, the animals were killed and eyes were enucleated. Eye globes were further cryosectioned in 10-m thick midsagittal sections. For the detection of apoptosis, the TUNEL method was applied.Results:TUNEL-positive signals were observed in the superficial epithelial cells in the exposed and control eyes at all latency periods. At 5 hours, TUNEL staining was detected in the exposed corneas in epithelial cells, keratocytes, and endothelial cells with a maximum signal at 24 hours. At 120 hours, no TUNEL staining was found in endothelial cells and only occasionally in keratocytes in exposed corneas. Signs of ulceration and stromal thinning were observed at 120 hours.Conclusions:UVR in the 300-nm wavelength region induces TUNEL staining in all 3 corneal layers. TUNEL staining of all 3 corneal layers is an early postexposure event observed after a 5-hour latency period. Corneal sterile keratolysis occurs in the time window of 24 to 120 hours probably induced by neutrophils.

  • 106.
    Kronschläger, Martin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Prevention of Experimental Cataract Induced by UVR2014Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Cataract is the leading cause of blindness in the world and is defined by opacification of the normally transparent lens of the eye. The major avoidable cause of cataract is ultraviolet radiation (UVR), but no current strategies have been developed to prevent the onset of cataract. Apoptosis and internal and external antioxidant systems that inhibit apoptosis have been shown to play a significant role in cataractogenesis.

    The main purposes of this thesis were to study the time evolution of apoptosis, to develop the concept of a protection factor (PF), and to investigate the effect of thioltransferase (Grx1) and topical caffeine in UVR cataract development. Further, to elucidate pharmacokinetics and influence on iris diameter of topical caffeine.

    Sprague Dawley rats were exposed to UVR and TUNEL staining of the lens sections was analysed. Grx1+/+ and Grx1-/- mice were exposed to 5 sub-doses of UVR. Based on the difference of light scattering between Grx1+/+ and Grx1-/- mice, the concept of the PF was developed. Topical caffeine and a placebo were applied to the eyes of separate groups of Sprague Dawley rats that were exposed to sub-doses of UVR and protective effect was evaluated. Penetration of topical caffeine in Sprague Dawley rats to lens and blood was analysed by high performance liquid chromatography. Pupil diameter was measured in groups of unilaterally and bilaterally caffeine-treated ketamine/xylazine anesthetized Sprague Dawley rats.

    TUNEL-labeling peaked between 5 and 120 hours after UVR exposure. The PF of Grx1 was 1.3. Moreover, topically administered caffeine protected against UVR-induced cataract development with a PF of 1.23. Topical caffeine peaked at 30 min in the lens, increased up to 120 min in the blood and antagonized ketamine/xylazine-induced mydriasis.

    In conclusion, UVR induces apoptosis, which is evidenced by the peak of TUNEL-labeling at 24 hours after UVR exposure. The PF is an objective relative measure of protective properties that allows the comparison of different antioxidant systems and administered antioxidant substances. Grx1 and caffeine are protective against UVR-induced cataract. Topically administered caffeine penetrates to the lens and inhibits UVR-induced apoptosis. Additionally, a miotic effect of caffeine is described for the first time.

    Delarbeten
    1. Evolution of TUNEL-labeling in the Rat Lens After In Vivo Exposure to Just Above Threshold Dose UVB
    Öppna denna publikation i ny flik eller fönster >>Evolution of TUNEL-labeling in the Rat Lens After In Vivo Exposure to Just Above Threshold Dose UVB
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    2013 (Engelska)Ingår i: Current Eye Research, ISSN 0271-3683, E-ISSN 1460-2202, Vol. 38, nr 8, s. 880-885Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Purpose/Aim:

    To quantitatively analyse the evolution of TUNEL-labeling, after in vivo exposure to UVB.

    Methods:

    Altogether, 16 Sprague Dawley rats were unilaterally exposed in vivo for 15 min to close to threshold dose, 5 kJ/m(2), of ultraviolet radiation in the 300nm wavelength region. Animals were sacrificed in groups of 4 at 1, 5, 24 and 120 h after exposure. For each animal, both eye globes were removed and frozen. The frozen eye was cryo-sectioned in 10 mm thick midsagittal sections. From each globe, three midsagittal sections with at least five sections interval in between were mounted on a microscope slide. Sections were TUNEL-labeled and counter stained with DAPI. For quantification of apoptosis, a fluorescence microscope was used. In sections with a continuous epithelial cell surface, the number of lens epithelial cell nuclei and the number of TUNEL-positive epithelial cell nuclei was counted. The total number of TUNEL-positive epithelial cell nuclei for all three sections of one lens in relation to the total number of epithelial cell nuclei for all three sections of the same lens was compared between exposed and contralateral not exposed lens for each animal.

    Results:

    The relative difference of the fraction of TUNEL-positive nuclei between exposed and contralateral not exposed lens increased gradually, peaked in the time interval 5-120 h after exposure, and then declined.

    Conclusions:

    Close to threshold dose of UVB induces TUNEL-labeling that peaks in the time window 5-120 h after exposure to UVB.

    Nyckelord
    Apoptosis, cataract, in vivo exposure, Sprague Dawley rats, ultraviolet radiation
    Nationell ämneskategori
    Oftalmologi
    Identifikatorer
    urn:nbn:se:uu:diva-204768 (URN)10.3109/02713683.2013.783079 (DOI)000321010100009 ()
    Tillgänglig från: 2013-08-15 Skapad: 2013-08-12 Senast uppdaterad: 2017-12-06Bibliografiskt granskad
    2. Protective Effect of The Thioltransferase Gene On In Vivo UVR-300 nm Induced Cataract: In vivo protection of Grx1 against UVR in the lens
    Öppna denna publikation i ny flik eller fönster >>Protective Effect of The Thioltransferase Gene On In Vivo UVR-300 nm Induced Cataract: In vivo protection of Grx1 against UVR in the lens
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    2012 (Engelska)Ingår i: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 53, nr 1, s. 248-252Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Purpose. To determine the protection factor (PF) for glutaredoxin-1 (Grx1) with regard to UVR-induced cataract by comparison of in vivo ultraviolet radiation (UVR) lens toxicity between double knockout Grx1−/− and Grx1+/+ mice.

    Methods. Twenty Grx1+/+ mice and 20 Grx1/ mice were unilaterally exposed in vivo to UVR for 15 minutes. Groups of four animals each received 0.0, 2.1, 2.9, 3.6, and 4.1 kJ/m2 UVR-300 nm. At 48 hours after UVR exposure, light-scattering in the exposed and contralateral nonexposed lenses was measured quantitatively. Macroscopic lens changes were documented with dark-field illumination photography.

    Results. UVR-300 nm induced subcapsular and cortical cataract in Grx1−/− and Grx1+/+ mice. In both Grx1−/− and Grx1+/+, the light-scattering intensified with increased in vivo exposure doses of UVR-300 nm. The intensity of forward light-scattering was higher in the lenses of Grx1−/− mice than in the lenses of Grx1+/+ mice. The threshold dose for in vivo UVR-300 nm–induced cataract, expressed as MTD2.3:16, was 3.8 in the Grx1+/+ group and 3.0 in the Grx1−/− group, resulting in a PF of 1.3.

    Conclusions. The PF is an objective relative measure of protective properties. The Grx1 gene is associated with an in vivo PF of 1.3. This result signifies that the presence of the gene allows a 1.3 times longer in vivo exposure to UVR, at equivalent irradiance, than the absence of the gene before early-onset, UVR-induced cataract occurs. This finding indicates the important role of the Grx1 gene in the oxidation defense system of the lens.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Forskningsämne
    Oftalmiatrik
    Identifikatorer
    urn:nbn:se:uu:diva-163795 (URN)10.1167/iovs.11-8504 (DOI)000302694500039 ()
    Tillgänglig från: 2011-12-14 Skapad: 2011-12-14 Senast uppdaterad: 2017-12-08Bibliografiskt granskad
    3. Caffeine eye drops protect against UV-B cataract
    Öppna denna publikation i ny flik eller fönster >>Caffeine eye drops protect against UV-B cataract
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    2013 (Engelska)Ingår i: Experimental Eye Research, ISSN 0014-4835, E-ISSN 1096-0007, Vol. 113, s. 26-31Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    The purpose of this study was to investigate if topically applied caffeine protects against in vivo ultraviolet radiation cataract and if so, to estimate the protection factor. Three experiments were carried out. First, two groups of Sprague-Dawley rats were pre-treated with a single application of either placebo or caffeine eye drops in both eyes. All animals were then unilaterally exposed in vivo to 8 kJ/m(2) UV-B radiation for 15 min. One week later, the lens GSH levels were measured and the degree of cataract was quantified by measurement of in vitro lens light scattering. In the second experiment, placebo and caffeine pre-treated rats were divided in five UV-B radiation dose groups, receiving 0.0, 2.6, 3.7, 4.5 or 5.2 kJ/m(2) UV-B radiation in one eye. Lens light scattering was determined after one week. In the third experiment, placebo and caffeine pre-treated rats were UV-B-exposed and the presence of activated caspase-3 was visualized by immunohistochemistry. There was significantly less UV-B radiation cataract in the caffeine group than in the placebo group (95% confidence interval for mean difference in lens light scattering between the groups = 0.10 +/- 0.05 tEDC), and the protection factor for caffeine was 1.23. There was no difference in GSH levels between the placebo- and the caffeine group. There was more caspase-3 staining in UV-B-exposed lenses from the placebo group than in UV-B-exposed lenses from the caffeine group. Topically applied caffeine protects against ultraviolet radiation cataract, reducing lens sensitivity 1.23 times.

    Nyckelord
    caffeine, cataract, ultraviolet radiation, protection factor
    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:uu:diva-208371 (URN)10.1016/j.exer.2013.04.015 (DOI)000322931700004 ()
    Tillgänglig från: 2013-09-30 Skapad: 2013-09-30 Senast uppdaterad: 2017-12-06Bibliografiskt granskad
    4. Pharmacokinetics for topically applied caffeine in the rat
    Öppna denna publikation i ny flik eller fönster >>Pharmacokinetics for topically applied caffeine in the rat
    Visa övriga...
    2014 (Engelska)Ingår i: Experimental Eye Research, ISSN 0014-4835, E-ISSN 1096-0007, Vol. 122, s. 94-101Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Topically applied caffeine was recently identified as a promising candidate molecule for cataract prevention. Little is known about the pharmacokinetics for topically applied caffeine. Potential toxicity of 72 mM caffeine on the ocular surface and the lens was qualitatively monitored and no toxic effects were observed. The concentration of caffeine was measured in the lens and the blood after topical application of 72 mM caffeine to groups of 10 animals sacrificed at 30, 60, 90 and 120 min after topical application. The lens concentration decreased throughout the observation period while the blood concentration increased up to 120 min. Further, the concentration of caffeine in the lens and blood was measured 30 min after topical application of caffeine, the concentration of caffeine being 0.72, 3.34, 15.51 and 72 mM depending on group belonging, in groups of 10 animals. The caffeine concentration in lens and blood, respectively, increased proportionally to the caffeine concentration topically applied. The rat blood concentrations achieved were far below the equivalent threshold dose of FDA recommended daily dose for humans. This information is important for further development of caffeine eye drops for cataract prevention.

    Nationell ämneskategori
    Oftalmologi
    Identifikatorer
    urn:nbn:se:uu:diva-224891 (URN)10.1016/j.exer.2014.03.009 (DOI)000336009500012 ()
    Tillgänglig från: 2014-05-22 Skapad: 2014-05-22 Senast uppdaterad: 2017-12-05Bibliografiskt granskad
    5. Topically applied caffeine induces miosis in the ketamine/xylazine anesthetized rat
    Öppna denna publikation i ny flik eller fönster >>Topically applied caffeine induces miosis in the ketamine/xylazine anesthetized rat
    Visa övriga...
    2014 (Engelska)Ingår i: Experimental Eye Research, ISSN 0014-4835, E-ISSN 1096-0007, Vol. 127, s. 179-183Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    The aim of the present study was to examine if topically applied caffeine influences pupil size in ketamine/xylazine anesthetized animals. Two experiments were carried out. In the first experiment, caffeine was topically applied to one of the eyes of 10 ketamine/xylazine anesthetized animals, while vehicle only was topically applied to the contralateral eye. In the second experiment, caffeine was topically applied to both eyes in one group of 10 ketamine/xylazine anesthetized rats, while in another group both eyes vehicle only was topically applied to both eyes. In both experiments pupil diameter was measured at 0, 10, 20, 40 and 60 min after topical application. In three of the animals, the pupil was dilated with tropicamide 5 mg/ml at 60 min after the topical application of caffeine and the pupil diameter was measured. The first experiment showed a relative miosis in caffeine treated eyes as compared to the vehicle treated eye, that changed over time. The second experiment in line with the first experiment, also showed that topically applied caffeine causes a relative miosis as compared to vehicle only that changes over time. Eyes treated with caffeine reacted with quick dilatation after tropicamide application. Topical caffeine antagonizes ketamine/xylazine anesthesia induced mydriasis in a time dependent manner.

    Nationell ämneskategori
    Oftalmologi
    Identifikatorer
    urn:nbn:se:uu:diva-229926 (URN)10.1016/j.exer.2014.07.023 (DOI)000342539900021 ()
    Tillgänglig från: 2014-08-18 Skapad: 2014-08-18 Senast uppdaterad: 2017-12-05Bibliografiskt granskad
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  • 107.
    Kronschläger, Martin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Forsman, Erik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Yu, Zhaohua
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Talebizadeh, Nooshin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Löfgren, Stefan
    Meyer, Linda M
    Bergquist, Jonas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Söderberg, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Pharmacokinetics for topically applied caffeine in the rat2014Ingår i: Experimental Eye Research, ISSN 0014-4835, E-ISSN 1096-0007, Vol. 122, s. 94-101Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Topically applied caffeine was recently identified as a promising candidate molecule for cataract prevention. Little is known about the pharmacokinetics for topically applied caffeine. Potential toxicity of 72 mM caffeine on the ocular surface and the lens was qualitatively monitored and no toxic effects were observed. The concentration of caffeine was measured in the lens and the blood after topical application of 72 mM caffeine to groups of 10 animals sacrificed at 30, 60, 90 and 120 min after topical application. The lens concentration decreased throughout the observation period while the blood concentration increased up to 120 min. Further, the concentration of caffeine in the lens and blood was measured 30 min after topical application of caffeine, the concentration of caffeine being 0.72, 3.34, 15.51 and 72 mM depending on group belonging, in groups of 10 animals. The caffeine concentration in lens and blood, respectively, increased proportionally to the caffeine concentration topically applied. The rat blood concentrations achieved were far below the equivalent threshold dose of FDA recommended daily dose for humans. This information is important for further development of caffeine eye drops for cataract prevention.

  • 108.
    Kronschläger, Martin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Yu, Zhaohua
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Talebizadeh, Nooshin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Meyer, Linda M.
    Hallböök, Finn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Medicinsk utvecklingsbiologi.
    Söderberg, Per G.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Evolution of TUNEL-labeling in the Rat Lens After In Vivo Exposure to Just Above Threshold Dose UVB2013Ingår i: Current Eye Research, ISSN 0271-3683, E-ISSN 1460-2202, Vol. 38, nr 8, s. 880-885Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose/Aim:

    To quantitatively analyse the evolution of TUNEL-labeling, after in vivo exposure to UVB.

    Methods:

    Altogether, 16 Sprague Dawley rats were unilaterally exposed in vivo for 15 min to close to threshold dose, 5 kJ/m(2), of ultraviolet radiation in the 300nm wavelength region. Animals were sacrificed in groups of 4 at 1, 5, 24 and 120 h after exposure. For each animal, both eye globes were removed and frozen. The frozen eye was cryo-sectioned in 10 mm thick midsagittal sections. From each globe, three midsagittal sections with at least five sections interval in between were mounted on a microscope slide. Sections were TUNEL-labeled and counter stained with DAPI. For quantification of apoptosis, a fluorescence microscope was used. In sections with a continuous epithelial cell surface, the number of lens epithelial cell nuclei and the number of TUNEL-positive epithelial cell nuclei was counted. The total number of TUNEL-positive epithelial cell nuclei for all three sections of one lens in relation to the total number of epithelial cell nuclei for all three sections of the same lens was compared between exposed and contralateral not exposed lens for each animal.

    Results:

    The relative difference of the fraction of TUNEL-positive nuclei between exposed and contralateral not exposed lens increased gradually, peaked in the time interval 5-120 h after exposure, and then declined.

    Conclusions:

    Close to threshold dose of UVB induces TUNEL-labeling that peaks in the time window 5-120 h after exposure to UVB.

  • 109.
    Kronschläger, Martin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Yu, Zhaohua
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Talebizadeh, Nooshin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Meyer, Linda Maren
    Söderberg, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Topically applied caffeine induces miosis in the ketamine/xylazine anesthetized rat2014Ingår i: Experimental Eye Research, ISSN 0014-4835, E-ISSN 1096-0007, Vol. 127, s. 179-183Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim of the present study was to examine if topically applied caffeine influences pupil size in ketamine/xylazine anesthetized animals. Two experiments were carried out. In the first experiment, caffeine was topically applied to one of the eyes of 10 ketamine/xylazine anesthetized animals, while vehicle only was topically applied to the contralateral eye. In the second experiment, caffeine was topically applied to both eyes in one group of 10 ketamine/xylazine anesthetized rats, while in another group both eyes vehicle only was topically applied to both eyes. In both experiments pupil diameter was measured at 0, 10, 20, 40 and 60 min after topical application. In three of the animals, the pupil was dilated with tropicamide 5 mg/ml at 60 min after the topical application of caffeine and the pupil diameter was measured. The first experiment showed a relative miosis in caffeine treated eyes as compared to the vehicle treated eye, that changed over time. The second experiment in line with the first experiment, also showed that topically applied caffeine causes a relative miosis as compared to vehicle only that changes over time. Eyes treated with caffeine reacted with quick dilatation after tropicamide application. Topical caffeine antagonizes ketamine/xylazine anesthesia induced mydriasis in a time dependent manner.

  • 110.
    Lagali, Neil S.
    et al.
    Linkoping Univ, Ophthalmol, Linkoping, Sweden..
    Allgeier, Stephan
    Karlsruhe Inst Technol, Karlsruhe, Germany..
    Guimaraes, Pedro
    Univ Padua, Dept Informat Engn, Padua, Italy..
    Badian, Reza A.
    Buskerud & Vestfold Univ Coll, Drammen, Norway..
    Ruggeri, Alfredo
    Univ Padua, Dept Informat Engn, Padua, Italy..
    Koehler, Bernd
    Karlsruhe Inst Technol, Karlsruhe, Germany..
    Utheim, Tor Paaske
    Univ Oslo, Oslo, Norway..
    Peebo, Beatrice Bourghardt
    Linkoping Univ, Ophthalmol, Linkoping, Sweden..
    Peterson, Magnus
    Uppsala University.
    Dahlin, Lars
    Lund Univ, Lund, Sweden..
    Rolandsson, Olov
    Umea Univ, Umea, Sweden..
    Analysis of corneal subbasal nerve plexus from wide-area mosaics in healthy subjects and in type 2 diabetics2016Ingår i: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 57, nr 12Artikel i tidskrift (Refereegranskat)
  • 111.
    Lagali, Neil S.
    et al.
    Linkoping Univ, Inst Clin & Expt Med, Dept Ophthalmol, Linkoping, Sweden..
    Allgeier, Stephan
    Karlsruhe Inst Technol, Inst Appl Comp Sci, Karlsruhe, Germany..
    Guimaraes, Pedro
    Univ Padua, Dept Informat Engn, Padua, Italy..
    Badian, Reza A.
    Univ Coll Southeast Norway, Fac Hlth Sci, Kongsberg, Norway.;Oslo Univ Hosp, Dept Med Biochem, Oslo, Norway.;Univ Bergen, Stavanger Univ Hosp, Fac Med, Stavanger Clin Inst 1,Dept Ophthalmol, Bergen, Norway..
    Ruggeri, Alfredo
    Univ Padua, Dept Informat Engn, Padua, Italy..
    Koehler, Bernd
    Karlsruhe Inst Technol, Inst Appl Comp Sci, Karlsruhe, Germany..
    Utheim, Tor Paaske
    Univ Coll Southeast Norway, Fac Hlth Sci, Kongsberg, Norway.;Oslo Univ Hosp, Dept Med Biochem, Oslo, Norway..
    Peebo, Beatrice
    Linkoping Univ, Inst Clin & Expt Med, Dept Ophthalmol, Linkoping, Sweden..
    Peterson, Magnus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Dahlin, Lars B.
    Lund Univ, Skane Univ Hosp, Dept Translat Med Hand Surg, Malmo, Sweden..
    Rolandsson, Olov
    Umea Univ, Dept Publ Hlth & Clin Med, Sect Family Med, Umea, Sweden..
    Reduced Corneal Nerve Fiber Density in Type 2 Diabetes by Wide-Area Mosaic Analysis2017Ingår i: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 58, nr 14, s. 6318-6327Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PURPOSE

    To determine if corneal subbasal nerve plexus (SBP) parameters derived from wide-area depth-corrected mosaic images are associated with type 2 diabetes.

    METHODS

    One hundred sixty-three mosaics were produced from eyes of 82 subjects by laser-scanning in vivo confocal microscopy (IVCM). Subjects were of the same age, without (43 subjects) or with type 2 diabetes (39 subjects). Mosaic corneal nerve fiber length density (mCNFL) and apical whorl corneal nerve fiber length density (wCNFL) were quantified and related to the presence and duration of diabetes (short duration < 10 years and long duration >= 10 years).

    RESULTS

    In mosaics with a mean size of 6 mm(2) in subjects aged 69.1 +/- 1.2 years, mCNFL in type 2 diabetes was reduced relative to nondiabetic subjects (13.1 +/- 4.2 vs. 15.0 +/- 3.2 mm/mm(2), P = 0.018). Also reduced relative to nondiabetic subjects was mCNFL in both short-duration (14.0 +/- 4.0 mm/mm(2), 3.2 +/- 3.9 years since diagnosis) and long-duration diabetes (12.7 +/- 4.2 mm/mm(2), 15.4 +/- 4.2 years since diagnosis; ANOVA P = 0.023). Lower mCNFL was associated with presence of diabetes (P = 0.032) and increased hemoglobin A1c (HbA1c) levels (P = 0.047). By contrast, wCNFL was unaffected by diabetes or HbA1c (P > 0.05). Global SBP patterns revealed marked degeneration of secondary nerve fiber branches outside the whorl region in long-duration diabetes.

    CONCLUSIONS

    Wide-area mosaic images provide reference values for mCNFL and wCNFL and reveal a progressive degeneration of the SBP with increasing duration of type 2 diabetes.

  • 112.
    Larsson, E
    et al.
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Oftalmiatrik.
    Rydberg, A
    Holmström, G
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Oftalmiatrik.
    A population-based study of the refractive outcome in 10-year-old preterm and full-term children.2003Ingår i: Arch Ophthalmol, Vol. 121, s. 1430-1436Artikel i tidskrift (Refereegranskat)
  • 113.
    Larsson, Eva
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Short- and Long-Term Follow-Up of Ophthalmological Findings in Preterm Infants and Children2004Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    In a prospective population-based study in Stockholm County, 1998-2000, the incidence of retinopathy of prematurity (ROP) was investigated and was found to be 36% in prematurely-born infants with a birth weight of ≤ 1500 grams. Compared to a study performed ten years ago, the overall incidence was unchanged, but was reduced in “mature” infants and increased in immature ones. The incidence of ROP was 25% in infants with a gestational age of ≤ 32 weeks at birth. The main risk factors for ROP were the gestational age at birth, followed by the birth weight. Current guidelines for ROP screening in Sweden were modified.

    A 10-year follow-up study of the ophthalmological findings in prematurely-born children, previously included in a prospective population-based incidence study of ROP, was performed. The children were compared with full-term ones.

    Prematurely-born children ran a four times higher risk of refractive errors than full-term ones. The cryotreated children had the highest risk, but those without ROP also had more refractive errors than the full-terms. Within the group of prematurely-born children, the cryotreated ones had the highest prevalence of myopia, astigmatism and anisometropia, but no difference was found regarding hypermetropia.

    The visual acuity of prematurely-born children was poorer than that of the full-terms. The cryotreated children and those with neurological complications had the most marked reduction, but the children without ROP and neurological findings also had a poorer visual outcome than the full-terms. The prevalence of visual impairment was 1.8% among the prematurely-born children, and was due to ROP in half the cases and cerebral lesions in the others.

    The cryotreated children had constricted peripheral visual fields compared to the untreated prematurely-born and full-term children. The central visual fields tended to be reduced in the prematurely-born children compared to the full-terms, but no difference was observed within the preterm group.

    Delarbeten
    1. Incidence of ROP in two consecutive Swedish population based studies
    Öppna denna publikation i ny flik eller fönster >>Incidence of ROP in two consecutive Swedish population based studies
    Visa övriga...
    2002 Ingår i: British Journal of Ophthalmology, Vol. 86, nr 10, s. 1122-1126Artikel i tidskrift (Refereegranskat) Published
    Identifikatorer
    urn:nbn:se:uu:diva-91345 (URN)
    Tillgänglig från: 2004-02-26 Skapad: 2004-02-26Bibliografiskt granskad
    2. Screening for retinopathy of prematurity: evaluation and modification of guidelines
    Öppna denna publikation i ny flik eller fönster >>Screening for retinopathy of prematurity: evaluation and modification of guidelines
    2002 Ingår i: British Journal of Ophthalmology, Vol. 86, nr 12, s. 1399-1402Artikel i tidskrift (Refereegranskat) Published
    Identifikatorer
    urn:nbn:se:uu:diva-91346 (URN)
    Tillgänglig från: 2004-02-26 Skapad: 2004-02-26Bibliografiskt granskad
    3. A population-based study of the refractive outcome in 10-year-old preterm and full-term children
    Öppna denna publikation i ny flik eller fönster >>A population-based study of the refractive outcome in 10-year-old preterm and full-term children
    2003 Ingår i: Archives of Ophthalmology, Vol. 121, nr 10, s. 1430-1436Artikel i tidskrift (Refereegranskat) Published
    Identifikatorer
    urn:nbn:se:uu:diva-91347 (URN)
    Tillgänglig från: 2004-02-26 Skapad: 2004-02-26Bibliografiskt granskad
    4. A population-based study of the visual outcome in 10-year-old preterm and full-term children
    Öppna denna publikation i ny flik eller fönster >>A population-based study of the visual outcome in 10-year-old preterm and full-term children
    Artikel i tidskrift (Refereegranskat) Submitted
    Identifikatorer
    urn:nbn:se:uu:diva-91348 (URN)
    Tillgänglig från: 2004-02-26 Skapad: 2004-02-26Bibliografiskt granskad
    5. Peripheral and central visual fields in 11-year-old children who had been born prematurely and at term
    Öppna denna publikation i ny flik eller fönster >>Peripheral and central visual fields in 11-year-old children who had been born prematurely and at term
    2004 Ingår i: Journal of Pediatric Ophthalmology & Strabismus, Vol. 41, s. 39-45Artikel i tidskrift (Refereegranskat) Published
    Identifikatorer
    urn:nbn:se:uu:diva-91349 (URN)
    Tillgänglig från: 2004-02-26 Skapad: 2004-02-26Bibliografiskt granskad
    Ladda ner fulltext (pdf)
    FULLTEXT01
  • 114.
    Larsson, Eva
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Eriksson, Urban
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Alm, Albert
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Retinal nerve fibre layer thickness in full-term children assessed with Heidelberg retinal tomography and optical coherence tomography: normal values and interocular asymmetry2011Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 89, nr 2, s. 151-158Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: This study aimed to investigate normal values and interocular differences in retinal nerve fibre layer (RNFL) thickness, using optical coherence tomography (OCT) and Heidelberg retinal tomography (HRT), in 5-16-year-old children born at full-term with normal birthweights. Methods: Fifty-six children with normal visual acuity and refraction were examined with Stratus OCT and HRT. Three examinations were performed in each eye. One eye in each child was randomized for analyses of normal values. Findings in 54 eyes were evaluated. Mean values of RNFL thickness were calculated. Coefficients of variance and intraclass correlations were calculated. The correlation between right and left eyes and the limits of difference were determined for both methods. Results: Mean RNFL thickness was 98.4 mu m (standard deviation [SD] 7.88 mu m) assessed with OCT and 213.0 mu m (SD 54.0 mu m) assessed with HRT. No correlations between age or gender and RNFL thickness were found. The coefficients of variance were 2.9% and 5.6% for OCT and HRT, respectively, and intraclass correlations were 0.85 and 0.88, respectively. The limits of difference between the two eyes ranged from -9 mu m to 9 mu m with OCT and from -109 mu m to 87 mu m with HRT. Conclusions: Both OCT and HRT can be used in children aged 5-16 years, but OCT provides less variability in determinations of RNFL thickness, both in repeated examinations of the same eye and in comparisons between the two eyes. The present study provides values for normal RNFL thickness in healthy children which can be used to make comparisons with values in children with optic nerve diseases.

  • 115.
    Larsson, Eva
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Hellström, Ann
    Tornqvist, Kristina
    Wallin, Agneta
    Sunnqvist, Birgitta
    Sandgren Hochhard, Karin
    Lundgren, Pia
    Al-Hawasi, Abbas
    Teär Fahnehjelm, Kristina
    Gränse, Lotta
    Holmstrom, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Ophthalmological outcome of 6.5 years children treated for retinopathy of prematurity: a Swedish register study2023Ingår i: British Journal of Ophthalmology, ISSN 0007-1161, E-ISSN 1468-2079, s. bjo-2022Artikel i tidskrift (Refereegranskat)
  • 116.
    Larsson, Eva
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Hellström, Ann
    Tornqvist, Kristina
    Wallin, Agneta
    Sunnqvist, Birgitta
    Sandgren Hochhard, Karin
    Lundgren, Pia
    Al-Hawasi, Abbas
    Teär Fahnehjelm, Kristina
    Gränse, Lotta
    Holmström, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Ophthalmological outcome of 6.5 years children treated for retinopathy of prematurity: a Swedish register study2023Ingår i: British Journal of Ophthalmology, ISSN 0007-1161, E-ISSN 1468-2079, s. bjo-2022Artikel i tidskrift (Refereegranskat)
  • 117.
    Larsson, Eva
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Holmström, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Rydberg, Agneta
    Karolinska Institutet.
    Ophthalmological findings in 10-year-old full-term children: a population-based study2015Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 93, nr 2, s. 192-198Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose

    To determine different ophthalmological parameters in 10-year-old, healthy, full-term children in Stockholm County, Sweden.

    Methods

    Two hundred and seventeen children were included in the study. Best-corrected distance and near visual acuities (VA) were measured using logMAR charts. Cycloplegic retinoscopy was performed, and spherical equivalent and astigmatism were determined. Examination of ocular movement and cover test for distance and near were performed. Stereopsis was assessed with the TNO test, and contrast sensitivity with the Vistech test. The Royal Air Force rule was used for assessing accommodation, and near point of convergence was measured with the Lang fixation stick. Ophthalmoscopy was performed through dilated pupils.

    Results

    Eighty-two per cent of the children had a distance VA of −0.1 logMAR (1.3 Snellen acuity) or better. None of the children were visually impaired [VA >0.6 logMAR (<0.3 Snellen acuity)]. Ninety-three per cent had a near VA of −0.1 logMAR (1.25 Snellen acuity) or better. Mean spherical equivalent was 0.6 D. Eight (3.6%) children had hypermetropia (≥+2 D), and 17 (7.8%) were myopic (≤−0.5 D). Nine (4.1%) children had an astigmatism ≥1 D, and two (0.9%) had anisometropia of ≥1 D. Manifest strabismus was found in seven (3.2%) children, five of whom had exotropia. Heterophoria for distance and/or near was found in 80.2% of the children. In children without manifest strabismus, stereopsis >60 seconds of arc was found in five (2.4%). Three (1.4%) of 215 children had contrast sensitivity below normal limits. Binocular median near point of accommodation was 14 D, and median near point of convergence 6 cm.

    Conclusion

    Knowledge of various visual functions in normally developing children is crucial to be able to draw conclusions from ophthalmological examinations in children with eye diseases. This population-based study describes different ophthalmological parameters in full-term ten-year-old children. The material can be used as a control when examining children of similar ages with various ophthalmological conditions, such as groups of children with specific neurological or retinal diseases, and syndromes.

  • 118.
    Larsson, Eva
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Molnar, Anna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Holmström, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Repeatability, reproducibility and interocular difference in the assessments of optic nerve OCT in children– a Swedish population-based study2018Ingår i: BMC Ophthalmology, E-ISSN 1471-2415, Vol. 18, nr 270, artikel-id 30348126Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: The aim was, first, to collect normative data of the optic nerve head and the peripapillary retinal nerve fibre layer (RNFL) thickness assessed with Cirrus SD-OCT, in healthy children in a population-based study; second, using these data, to examine repeatability, reproducibility and the interocular difference.

    Methods: One-hundred and ten eyes from 57 children aged 6–15 born at term, were examined. Best-corrected visual acuity and refraction were assessed. Both eyes were examined and the interocular difference was calculated. Repeatability was calculated by one examiner performing three assessments. Thereafter, a second examiner repeated the assessments to calculate reproducibility.

    Results: Mean RNFL thickness was 99.2 (SD 8.8) μm, mean disc area 1.89 (SD 0.37) mm2 and mean rim area 1.52 (SD 0.26) mm2. No significant correlations with age, gender or refraction were found. Repeatability and reproducibility were good overall. There was interocular symmetry between the eyes.

    Conclusions: Normal values for optic nerve head and RNFL thickness assessed with Cirrus SD-OCT were gathered to obtain a normal material in children. High repeatability and reproducibility indicated reliability of assessments performed by different examiners on different occasions. Overall, good correlation between right and left eyes was found.

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  • 119.
    Larsson, Eva
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Nuija, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Alm, Albert
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    The optic nerve head assessed with HRT in 5-16-year-old normal children: normal values, repeatability and interocular difference2011Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 89, nr 8, s. 755-758Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: To investigate the normal values, repeatability and interocular difference of the optic nerve head, using Heidelberg retina tomography (HRT), in 5-16-year-old full-term children with normal birth weights. Methods: Fifty-six children with normal visual acuity and refraction were examined with HRT-II/III. Three examinations were performed on each eye. One eye was randomized for analyses of normal values and repeatability, and 54 eyes could be evaluated. The coefficient of variance and the intraclass correlation (ICC) were calculated, and the ISNT rule was noted. The correlation between right and left eyes and the limits of difference were determined in 50 pair of eyes. Results: The mean values of disc and rim areas were 2.16 (SD 0.47) and 1.75 (SD 0.39) mm(2) respectively. The coefficients of variance varied between optic nerve parameters from 1.8% to 21%, and the ICCs were >0.88. All parameters except retinal nerve fibre layer thickness correlated with the disc area. The ISNT rule was fulfilled in 56% of the eyes. The interocular difference was large but not statistically significant. Conclusion: We conclude that HRT can be used in children between 5 and 16 years of age, and normal values presented in the study can be used for comparison of children with optic nerve diseases. Because the assessment of rim area varied the least, it may be the parameter to use for follow-up. The normal large interocular difference should be taken into account when comparing eyes in the individual child.

  • 120.
    Larsson, Eva
    et al.
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Oftalmiatrik.
    Rydberg, Agneta
    Holmström, Gerd
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Oftalmiatrik.
    A Population-Based Study on the Visual Outcome in 10-Year-Old Preterm and Full-Term Children2005Ingår i: Arch Ophthalmol, Vol. 123, s. 825-832Artikel i tidskrift (Refereegranskat)
  • 121.
    larsson, Lill-Inger
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Oftalmiatrik.
    Aqueous Humor Flow in Normal Human Eyes Treated With Brimonidine and Timolol, Alone and in Combination2001Ingår i: Arch Ophthalmol, Vol. 119, s. 492-495Artikel i tidskrift (Refereegranskat)
  • 122. Lee, Richard
    et al.
    Cuthbertson, Fiona M
    Söderberg, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Liu, Christopher
    A possible strategy for implanting blue-blocking intraocular lenses2012Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 90, nr 2, s. e151-Artikel i tidskrift (Refereegranskat)
  • 123. Lindblad, Birgitta Ejdervik
    et al.
    Hakansson, Niclas
    Philipson, Bo
    Wolk, Alicja
    Alcohol consumption and risk of cataract extraction - A prospective cohort study of women2007Ingår i: Ophthalmology, ISSN 0161-6420, E-ISSN 1549-4713, Vol. 114, nr 4, s. 680-685Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: To investigate the association between alcohol consumption and the risk of cataract extraction. Design: Population-based prospective cohort study. Participants: A total of 34 713 women participating in the Swedish Mammography Cohort, age 49 to 83 years, completed in 1997 a self-administered questionnaire about alcohol, smoking, and other lifestyle factors. Methods: The women were followed from September 1997 through September 2004. The cohort was matched with registers of cataract extraction from the study area. Main Outcome Measures: Incident surgical extraction of age-related cataract. Results: During 84 months of follow-up, we found 3587 incident cases of age-related cataract extraction. Compared with never drinkers, the relative risk of cataract extraction among current drinkers was 1.11 (95% confidence interval [CI] 1.02-1.21) after adjustment for age and other potential risk factors. In multivariate analysis, an increment of 13 g alcohol intake per day (corresponding to 1 drink = 330 ml of beer, 150 ml of wine, or 45 ml of liquor) was associated with a 7% increased risk of cataract extraction (relative risk, 1.07; 95% Cl 1.02-1.12). Mean age at cataract extraction among nonsmoking women who used alcohol was 75 years, compared with 77.6 years among never drinkers. Conclusions: These prospective data suggest that daily use of = l alcoholic drinks was associated with a modest increase of risk for cataract extraction. The risk increased with increasing alcohol consumption.

  • 124.
    Lindblad, Birgitta Ejdervik
    et al.
    Sundsvall Hosp, Dept Ophthalmol, SE-85186 Sundsvall, Sweden.;Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden..
    Hakansson, Niclas
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden..
    Philipson, Bo
    HM Queen Sophia Hosp, Stockholm Eye Clin, Stockholm, Sweden..
    Wolk, Alicja
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden..
    Hormone Replacement Therapy in Relation to Risk of Cataract Extraction A Prospective Study of Women2010Ingår i: Ophthalmology, ISSN 0161-6420, E-ISSN 1549-4713, Vol. 117, nr 3, s. 424-430Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: To investigate the association between hormone replacement therapy (HRT) and the incidence of cataract extraction among postmenopausal women. Design: Population-based, prospective cohort study. Participants: A total of 30 861 postmenopausal women participating in the Swedish Mammography Cohort, age 49 to 83 years, who completed a self-administered questionnaire in 1997 about hormone status, HRT, and lifestyle factors. Methods: The women were followed from September 1997 through October 2005. The cohort was matched with registers of cataract extraction in the study area. Main Outcome Measures: Incident operative extraction of age-related cataract. Results: We identified 4324 incident cases of cataract extractions during 98 months of follow-up. In multivariate adjusted analysis, ever use of HRT was associated with a 14% increased risk of cataract extraction (rate ratio [RR], 1.14; 95% confidence interval [CI], 1.07-1.21) compared with those who never used HRT. Current use of HRT was associated with an 18% increased risk of cataract extraction (RR, 1.18; 95% CI, 1.10-1.26). A significant linear trend was observed where increasing duration of HRT usage resulted in an increased risk of cataract extraction (P for trend = 0.006). Multivariate RR for current HRT usage for >10 years was 1.20 (95% CI, 1.06-1.36; P for trend = 0.001). Among women drinking on average >1 drink of alcohol per day, current HRT users had a 42% increased risk (RR, 1.42; 95% CI, 1.11-1.80) for cataract extraction, compared with women who neither used HRT nor alcohol. The risk of cataract extraction among current users of HRT was similar among current smokers and those who never smoked. Conclusions: Our prospective, population-based study indicates that postmenopausal women using HRT for a long period of time may be at an increased risk for cataract extraction, especially those drinking >1 alcoholic drink daily. Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article. Ophthalmology 2010; 117: 424-430 (C) 2010 by the American Academy of Ophthalmology.

  • 125.
    Lindblad, Birgitta Ejdervik
    et al.
    Orebro Univ Hosp, Dept Ophthalmol, SE-70185 Orebro, Sweden.;Orebro Univ Hosp, Sch Hlth & Med Sci, SE-70185 Orebro, Sweden.;Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden..
    Hakansson, Niclas
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden..
    Wolk, Alicja
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden..
    Smoking Cessation and the Risk of Cataract A Prospective Cohort Study of Cataract Extraction Among Men2014Ingår i: JAMA ophthalmology, ISSN 2168-6165, E-ISSN 2168-6173, Vol. 132, nr 3, s. 253-257Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    IMPORTANCE Smoking is a risk factor for cataract development, but the effect of smoking cessation on the risk of cataract is uncertain. OBJECTIVE To examine the association between smoking cessation and the risk of cataract extraction. DESIGN, SETTING. AND PARTICIPANTS A total of 44 371 men, participating in the Cohort of Swedish Men, aged 45 to 79 years, who in 1997 completed a self-administered questionnaire on smoking habits and lifestyle factors. The men were followed up from January 1, 1998, through December 31, 2009. The cohort was matched with the Swedish National Day-Surgery Register and local registers of cataract extraction in the study area. MAIN OUTCOMES AND MEASURES Incident cases of age-related cataract extraction. RESULTS During 12 years of follow-up, we identified 5713 incident cases of age-related cataract extraction. Smoking intensity and cumulative dose of smoking were associated with an increased risk of cataract extraction (P for trend < .001). Current smokers of more than 15 cigarettes per day had a 42% increased risk of cataract extraction (rate ratio, 1.42; 95% CI, 1.28-1.58) compared with never smokers after adjustment for age and other potential risk factors. Smoking cessation significantly decreased the risk for cataract extraction with time (P for trend < .001). After more than 20 years since stopping smoking, men with a mean smoking intensity of more than 15 cigarettes per day had a 21% increased risk of cataract extraction (rate ratio, 1.21; 95% CI, 1.06-1.39) compared with never smokers. Among men who smoked 15 cigarettes or less per day, the effect of smoking cessation was observed earlier, but more than 2 decades after smoking cessation, the risk of cataract extraction did not decrease to the level of never smokers (rate ratio, 1.13; 95% CI, 1.04-1.24). CONCLUSIONS AND RELEVANCE Smoking cessation seems to decrease the risk of cataract extraction with time, although the risk persists for decades. The higher the intensity of smoking, the longer it takes for the increased risk to decline. These findings emphasize the importance of early smoking cessation and preferably the avoidance of smoking.

  • 126. Lindblad, Birgitta Ejdervik
    et al.
    Håkansson, Niclas
    Svensson, Hanna
    Philipson, Bo
    Wolk, Alicja
    Intensity of smoking and smoking cessation in relation to risk of cataract extraction: a prospective study of women2005Ingår i: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 162, nr 1, s. 73-9Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The authors investigated the association of smoking and smoking cessation with the incidence of cataract extraction in a population-based prospective cohort study. A total of 34,595 women aged 49-83 years in the Swedish Mammography Cohort were followed from September 1997 through June 2002. Information on smoking, diet, and other lifestyle factors was collected through a self-administered questionnaire. A total of 2,128 cases of age-related cataract extraction were identified. Relative risks were estimated as rate ratios using Cox proportional hazards models. The authors observed a significant dose-response association between intensity of smoking and risk of cataract extraction (among current smokers, p for trend = 0.02; among past smokers, p for trend = 0.0002). After cessation of smoking, the risk decreased with time. Among women with a moderate lifetime smoking intensity (6-10 cigarettes/day), the relative risk was not significantly different from the risk among never smokers 10 years after smoking cessation. Among women who had smoked more intensively (>10 cigarettes/day), after 20 years of nonsmoking the increased risk became small and no longer statistically significant in comparison with never smokers (for trend over time, p < 0.0001). This prospective study confirmed smoking as a risk factor for cataract, with a dose response for smoking intensity. Smoking cessation predicts reduced risk over time, but a longer period of time is needed with a higher smoking intensity.

  • 127.
    Lindblad, Birgitta Ejdervik
    et al.
    Department of Ophthalmology, School of Medical Sciences, Örebro University, Örebro, Sweden..
    Håkansson, Niclas
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden..
    Wolk, Alicja
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden..
    Metabolic syndrome and some of its components in relation to risk of cataract extraction.: A prospective cohort study of men2019Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, nr 4, s. 409-414Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PURPOSE: To evaluate the relationship between metabolic syndrome and some of its components with the incidence of cataract extraction.

    METHODS: A population-based prospective cohort with a total of 45 049 men, aged 45-79 years, from the Cohort of Swedish Men completed in 1997 a self-administered questionnaire concerning anthropometric measurements and lifestyle factors. The men were followed from 1 January 1998 through 31 December 2012, and the cohort was matched with registers of cataract extraction. The main outcome measure was incident cases of age-related cataract extraction.

    RESULTS: Over the 15-years of follow-up, 7573 incident cases of cataract extraction were identified. After controlling for potential confounders, the association between single components of metabolic syndrome, abdominal adiposity, diabetes and hypertension and risk of cataract extraction was rate ratio (RR): 1.04; 95% confidence interval (CI): 0.99-1.10, RR: 1.77; 95% CI: 1.64-1.92 and RR: 1.06; 95% CI 1.00-1.13, respectively. The risk of cataract extraction increased with increasing numbers of metabolic syndrome components (p < 0.0001). Men aged 65 years or younger at baseline with all three components of the metabolic syndrome had a relative risk of 2.43 (95% CI: 1.95-3.01) for cataract extraction.

    CONCLUSION: In this cohort of middle-aged and elderly men, metabolic syndrome with the combination of abdominal adiposity, diabetes and hypertension was associated with an increased risk for cataract extraction, especially among men aged 65 years or younger. These findings put emphasis on the importance of weight control and healthy lifestyle behaviours in order to prevent cataract.

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  • 128.
    Lindström, Björn E.
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning Dalarna. Falun Cent Hosp, Dept Ophthalmol, Falun, Sweden..
    Skogman, Barbro H.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning Dalarna. Örebro Univ, Fac Med & Hlth Sci, Örebro, Sweden..
    Lindström, Annika K
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Reproduktionsbiologi.
    Tallstedt, Leif
    St Eriks Eye Hosp, Dept Ophthalmol, Stockholm, Sweden..
    Nilsson, Kenneth
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Infektionssjukdomar. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk mikrobiologi.
    Borrelia Ocular Infection: A Case Report and a Systematic Review of Published Cases2022Ingår i: Ophthalmic Research, ISSN 0030-3747, E-ISSN 1423-0259, Vol. 65, nr 2, s. 121-130Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Introduction: Lyme borreliosis can cause many diverse manifestations, also ocular disease where the diagnosis of ocular borreliosis is challenging. The primary aim was to report on the evidence of Borrelia spirochetes in the ocular tissue in presumed ocular borreliosis.

    Methods: A systematic review of pathological eye conditions was performed where Borrelia has been suspected in relevant ocular tissue, together with a case report of diagnosed uveitis with polymerase chain reaction (PCR)-confirmed Borrelia afzelii in the vitreous. The evidence for clinical and laboratory diagnosis was evaluated systematically. As a secondary aim, the treatment of ocular Borrelia infection was also evaluated for confirmed cases.

    Results: Thirteen includable studies were found, and after the removal of case duplicates, eleven unique cases were extracted. Apart from the present case report, 4 other cases reported strong evidence for the detection of B. spirochetes in ocular tissue. Four cases presented reasonable evidence for assumed detected Borrelia, while three additional cases showed only weak diagnostic credibility that Borrelia was detected.

    Conclusion: This systematic review, including all reported cases and our case report, supports evidence of ocular infection of Borrelia species. Furthermore, in case of suspicion of infection and seronegativity, it is justified to look for Borrelia in eye tissue samples. In addition, microscopy without using PCR is not sufficient to confirm the diagnosis of borreliosis on ocular tissue. In the articles studied, there was no unambiguous recommendation of treatment.

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  • 129. Lindén, Christina
    et al.
    Bengtsson, Boel
    Alm, Albert
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Calissendorff, Berit
    Eckerlund, Ingemar
    Heijl, Anders
    Glaucoma management in Sweden: results from a nationwide survey2013Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 91, nr 1, s. 20-24Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: 

    To report the results from a nationwide survey on glaucoma management in Sweden, performed as a part of an Open Angle Glaucoma project conducted by the Swedish Council on Health Technology Assessment 2004-2008.

    Methods:

    In 2005, a survey was distributed to all providers of glaucoma care in Sweden: public eye departments, public outpatient departments and private practices. The questionnaire included questions on number of examined patients, types of examinations during one defined week, internal organization and access to diagnostic equipment. The questionnaire was endorsed by the Swedish Ophthalmological Society. Reminders were sent out to nonresponders.

    Results: 

    Response rate was high; 97% (33/34) of eye departments, 85% (39/46) of outpatient departments and 55% (69/125) of private practices. Out of 29 282 visits in ophthalmic care during the study week, 7737 (26%) were related to glaucoma. Diagnostic equipment was generally available; all public eye facilities and 92% of private practices had at least one computerized perimeter, while equipment for fundus photography/imaging was available at 100% of eye departments, 82% of outpatient departments and 62% of private practices. The number of visual field tests and fundus images was rather low. Survey results indicate that patients on the average underwent bilateral field testing every 2nd year and fundus imaging every 8th year.

    Conclusion:

    Glaucoma care generated about a quarter of all patient visits in Swedish ophthalmic care. Access to diagnostic facilities was good. To meet modern standards of glaucoma care, glaucoma damage must be measured and followed more closely than at the time of the survey.

  • 130.
    Lo Faro, Valeria
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Genomik och neurobiologi. Univ Groningen, Univ Med Ctr Groningen, Dept Ophthalmol, Groningen, Netherlands.
    Answer to the Hamlet-like dilemma of lipid metabolites causing senile macular degeneration2023Ingår i: Cell Reports Medicine, E-ISSN 2666-3791 , Vol. 4, nr 7, artikel-id 101077Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [en]

    In this issue of Cell Reports Medicine, Han et al.1 conducted a multi-ancestry genetic and metabolomic analysis to investigate the causal relationships between age-related macular degeneration and plasma and urine metabolites.

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  • 131.
    Lundgren, P.
    et al.
    Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden..
    Lundberg, L.
    Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden..
    Hellgren, G.
    Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden..
    Holmström, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Hard, A. L.
    Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden..
    Smith, L. E.
    Harvard Med Sch, Boston Childrens Hosp, Dept Ophthalmol, Boston, MA USA..
    Wallin, A.
    St Erik Eye Hosp, Stockholm, Sweden..
    Hallberg, B.
    Karolinska Inst, Stockholm, Sweden.;Univ Hosp, Dept Neonatol, Stockholm, Sweden..
    Hellstrom, A.
    Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden..
    Aggressive posterior retinopathy of prematurity is associated with multiple infectious episodes and thrombocytopenia2016Ingår i: European Journal of Pediatrics, ISSN 0340-6199, E-ISSN 1432-1076, Vol. 175, nr 11, s. 1842-1842Artikel i tidskrift (Refereegranskat)
  • 132.
    Lundgren, Pia
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci,Sahlgrenska Ctr Pediat Ophthal, Gothenburg, Sweden.;Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden..
    Jacobson, Lena
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Hard, Anna-Lena
    Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci,Sahlgrenska Ctr Pediat Ophthal, Gothenburg, Sweden..
    Al-Hawasi, Abbas
    Linköping Univ, Dept Clin & Expt Med, Linköping, Sweden..
    Larsson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Söderberg: Oftalmiatrik.
    Granse, Lotta
    Lund Univ, Skane Univ Hosp, Ophthalmol, Dept Clin Sci, Lund, Sweden..
    Saric, Marie
    Umeå Univ, Dept Clin Sci, Ophthalmol, Umeå, Sweden..
    Sunnqvist, Birgitta
    Lanssjukhuset Ryhov, Dept Ophthalmol, Jönköping, Sweden..
    Tornqvist, Kristina
    Lund Univ, Skane Univ Hosp, Ophthalmol, Dept Clin Sci, Lund, Sweden..
    Wallin, Agneta
    St Erik Eye Hosp, Stockholm, Sweden..
    Holmström, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Söderberg: Oftalmiatrik.
    Le Smith, Lois
    Harvard Med Sch, Boston Childrens Hosp, Dept Ophthalmol, Boston, MA 02115 USA..
    Morsing, Eva
    Skane Univ Hosp Lund, Clin Sci Lund, Dept Pediat, Lund, Sweden..
    Hellstrom, Ann
    Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci,Sahlgrenska Ctr Pediat Ophthal, Gothenburg, Sweden..
    High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born < 24 gestational weeks2021Ingår i: BMJ Open Ophthalmology, E-ISSN 2397-3269, Vol. 6, nr 1, artikel-id e000695Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective Prematurity is a major risk factor for retinopathy of prematurity (ROP). We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort.

    Methods and analysis Infants with completed ROP screening, born at <24 GA weeks, 2007-2018 in Sweden were included. Data of GA, birth weight (BW), sex, neonatal morbidities, maximal ROP stage, aggressive posterior ROP (APROP), ROP treatments, treatment modality and treatment centre were retrieved.

    Results In total, 399 infants, with a mean GA of 23.2 weeks (range 21.9-23.9) and a mean BW of 567 g (range 340-874), were included. ROP was detected in 365 (91.5%) infants, 173 (43.4%) were treated for ROP and 68 of 173 (39.3%) were treated more than once. As the first treatment, 142 (82.0%) received laser and 29 (16.1%) received intravitreal injection of antivascular endothelial growth factor (anti-VEGF). Retreatment was performed after first laser in 46 of 142 (32.4%) and in 20 of 29 (69.0%) after first anti-VEGF treatment. Retreatment rate was not associated with GA, BW or sex but with APROP, treatment method (anti-VEGF) and treatment centre where the laser was performed (p<0.001). Twenty eyes progressed to retinal detachment, and two infants developed unilateral endophthalmitis after anti-VEGF treatment.

    Conclusion Infants, born at <24 weeks' GA, had high rates of treatment-warranting ROP and retreatments. Treatment centre highly influenced the retreatment rate after laser indicating that laser treatment could be improved in some settings.

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  • 133.
    Löfgren, Stefan
    et al.
    Inst. för Klinisk Neurovetenskap, Karolinska Institutet.
    Michael, Ralph
    Barraquer Institute.
    Söderberg, Per G
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Impact of iris pigment and pupil size in ultraviolet radiation cataract in rat2012Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 90, nr 1, s. 44-48Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: To investigate the effect of iris pigment and pupil size in ultraviolet radiation (UVR)-induced cataract.

    Methods: Brown-Norway rats (pigmented) and Fischer-344 rats (non-pigmented) were unilaterally exposed in vivo to 5 kJ/m(2) UVR. Each strain was split into two groups, each receiving either mydriatic (tropicamide) or miotic (pilocarpine) eye-drops. One week after exposure, the degree of ocular inflammation and damage in the anterior segment was determined. The lenses were extracted, photographed and the degree of forward light scattering (cataract) was quantified.

    Results: The cataract types differed between the two strains. All Fischer rats developed macroscopically identifiable UVR cataract while only 41% of Brown-Norway rats did so. All groups except the miotic Brown-Norway developed significant light scattering. The Fischer rats developed 3-4-fold more lens light scattering than the Brown-Norway rats. The miotic Fischer group exhibited significantly more light scattering than the mydriatic Fischer group. There was no significant difference in light scattering between the two Brown-Norway groups. There was a correlation between ocular inflammation and degree of light scattering, with Brown-Norway rats exhibiting less inflammation and lens light scattering.

    Conclusions: Pigmented rats develop less UVR cataract and less ocular inflammation than non-pigmented rats. Pupil size plays a smaller role in UVR cataract development in pigmented rats than in non-pigmented. The role of UVR-induced ocular inflammation in cataract development is still ambiguous.

  • 134.
    Lövestam Adrian, Monica
    et al.
    Department of Ophthalmology Department of Clinical Sciences Lund Lund University Skane University Hospital Lund Sweden.
    Schroeder, Marion
    Department of Ophthalmology Department of Clinical Sciences Lund Lund University Skane University Hospital Lund Sweden.
    Westborg, Inger
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    What about the fellow eye in treatment of neovascular age‐related macular degeneration? Analysis of data from the Swedish macula register2022Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 100, nr 7, s. 769-774Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: To analyse the development of neovascular age-related macular degeneration (nAMD) in the fellow eye in patients initially presenting with unilateral nAMD, using data from the Swedish Macula Register.

    Methods: This observational study included data on treatment-naïve patients who initially underwent unilateral treatment for nAMD, and then required bilateral treatment, between 2010 and 2018, according to the Swedish Macula Register (SMR). The data were also stratified according into three time periods (2010–2013; 2014–2016; 2017–2018). Treatment duration, best-corrected visual acuity (BCVA) in the first and second eye, number of injections in the first eye before falling ill in the second, and the time between the last injection in the first eye and the start of treatment of the fellow eye were analysed.

    Results: 5216 out of 28 670 (18%) patients treated for nAMD subsequently required bilateral treatment. The mean age was 77.7 ± 7.3 years, and 69% were female. The mean duration of treatment of the first eye before nAMD was diagnosed in the fellow eye was 1.58 years, and the mean number of injections in the first eye was 8.9 ± 8.6. Best-corrected visual acuity, according to the ETDRS chart, was higher in the second eye at the time when treatment started in that eye compared to treatment start in the first eye: 62.8 (14.7) versus 57.6 (15.5); p < 0.001, and was higher in the 66% whose first eye was still undergoing treatment: 63.6 ± 14.5 versus 61.0 ± 14.8; p = 0.001.

    Conclusions: The mean duration of treatment of the first eye before treatment started in the fellow eye was 19 months, and treatment of the second eye had started within 2 years in 61% of the patients. Best-corrected visual acuity was higher in the second eye than in the first eye at the start of treatment of that eye and was higher in the second eye at the start of treatment of that eye when the first eye was still being treated.

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  • 135.
    Madsen, Kim B.
    et al.
    Falu Hospital, Section of Opthalmology.
    Wallménius, Katarina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk mikrobiologi.
    Fridman, Åke
    Falu Hospital, Section of Opthalmology.
    Påhlson, Carl
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk mikrobiologi.
    Nilsson, Kenneth
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Infektionssjukdomar. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk mikrobiologi. Falu Hospital, Centre of Clinical Research.
    Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveiti: A Prospective Survey2017Ingår i: Journal of Ophthalmology, ISSN 2090-004X, E-ISSN 2090-0058, artikel-id 9247465Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Vector-borne diseases such as Lyme borreliosis and rickettsioses have been associated with ocular inflammation. Our aim was to study patients with diagnosed uveitis to evaluate serological signs of infection or exposure to these tick-borne agents. Forty-eight patients were prospectively examined with serology together with medical records and a questionnaire concerning previous exposure, diseases, and treatments. Seven patients (14.6%) showed seroconversion to Rickettsia spp. between acute and convalescent phase sera, which provides support for a positive Rickettsia diagnosis according to guidelines. The specificity was confirmed by Western blot. Additional 28 patients had stationary titres of which eight (16.6%) had 1 : 256 or higher titre in the first serum, and another 13 patients were seronegative. No epidemiological risk factor or marker could be identified. For Borrelia, only three patients showed moderate IgG titres. A control group of 100 blood donors, 60 patients with rheumatic disease, and 56 patients seeking medical care were tested of which 2.0–7.1% showed low anti-Rickettsia titres and 3.0–8.3% anti-Borrelia titres. The findings are indicative for an association between infection or exposure to Rickettsia spp. and uveitis with a seropositivity among patients with recurrent uveitis in concordance with the spread of rickettsial exposure in a tick-exposed population.

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  • 136.
    Malmberg, Filip
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Avdelningen för visuell information och interaktion. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Bildanalys och människa-datorinteraktion.
    Sandberg-Melin, Camilla
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik. Center for Research and Development, Region Gävleborg.
    Söderberg, Per G.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Estimating a structural bottle neck for eye–brain transfer of visual information from 3D-volumes of the optic nerve head from a commercial OCT device2016Ingår i: Ophthalmic Technologies XXVI, Bellingham, WA: SPIE - International Society for Optical Engineering, 2016, artikel-id 96930NKonferensbidrag (Refereegranskat)
  • 137.
    Malmqvist, Lars D.
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Söderberg, Per G.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    The Uppsala Contrast Sensitivity Test (UCST) - A fast strategy for clinical assessment of spectral contrast sensitivity2014Ingår i: Ophthalmic Technologies XXIV, 2014, s. 89300H-Konferensbidrag (Refereegranskat)
    Abstract [en]

    Routine clinical measurement of spectral contrast sensitivity is hampered by the time consumption of current methods. We are developing a system that allows instantaneous measurement of spectral contrast sensitivity. The UCST system consists of custom software running on an iPad connected to a calibrated TFT-monitor. Twenty healthy subjects were consecutively randomized to have their spectral contrast sensitivity measured with the UCST strategy or with a Vistech VCTS 6500 chart. The examination time and the spectral contrast sensitivity, respectively, were recorded for each eye in each subject. The Vistech strategy resulted in a more extended mean examination time (CI- Vistech: mu (0.95) = 87 +/- 27 s, d.f. = 9) than the UCST strategy (CI- UCST: mu (0.95) = 13 +/- 4 s, d.f. = 9), and the estimated mean difference between the two strategies indicated a difference in examination time (CI- difference: mu (0.95) = [47; 106] s, d.f. = 18). The overall contrast sensitivity for each group was estimated as the contrast sensitivities for the spatial frequencies sampled, integrated over the spatial frequency band sampled. The Vistech strategy resulted in a higher estimated mean overall contrast sensitivity (CI-Vistech: mu (0.95) = 116 +/- 24 log rel. log [c. deg(-1)], d.f. = 9) than the UCST strategy (CIUCST: mu (0.95) = 74 +/- 14 log rel. log [c. deg(-1)], d.f. = 9), and the estimated mean difference between the two strategies indicated a difference in overall contrast sensitivity (CI-difference: mu (0.95) = [15; 68] log rel. log [c. deg(-1)]), d.f. = 18). It is concluded that the UCST strategy measures spectral contrast sensitivity on the order of 7 times faster than the Vistech strategy. The slightly lower overall contrast sensitivity recorded for the UCST strategy appeared to be due to a limitation in dynamic range that can be overcome with improved design.

  • 138.
    Malmqvist, Lars
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Söderberg, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    The Uppsala Contrast Sensitivity Test: Fast contrast sensitivity measurements in humans.2014Ingår i: Proceedings of the VII European/ I World Meeting in Visual and Physiological Optics, 2014, s. 202-205Konferensbidrag (Refereegranskat)
  • 139.
    Manns,
    et al.
    Bascom Palmer Eye Institute, UM, FL, USA.
    Söderberg, Per GUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.Ho, ArthurVision CRC, Sydney, Australia.
    Ophthalmic Technologies XV2005Proceedings (redaktörskap) (Övrigt vetenskapligt)
  • 140.
    Manns, Fabrice
    et al.
    Bascom Palmer Eye Institute, Miami, FL, USA.
    Söderberg, PerUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Ophtahlmic technologies  XX2010Proceedings (redaktörskap) (Övrig (populärvetenskap, debatt, mm))
  • 141.
    Manns, Fabrice
    et al.
    Bascom Palmer Eye Institute, Miami, FL, USA.
    Söderberg, Per GUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Ophthalmic Technologies XIX2009Proceedings (redaktörskap) (Övrigt vetenskapligt)
  • 142.
    Manns, Fabrice
    et al.
    Bascom Palmer Eye Institute, UM, FL, USA.
    Söderberg, Per GUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.Ho, ArthurVision CRC, SYDNEY, AUSTRALIA.
    Ophthalmic Technolgies XVII2007Proceedings (redaktörskap) (Övrig (populärvetenskap, debatt, mm))
  • 143.
    Manns, Fabrice
    et al.
    Bascom Palmer Eye Institute, UM, FL, USA.
    Söderberg, Per GUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.Ho, ArthurVision CRC, SYDNEY, AUSTRALIA.
    Ophthalmic Technologies XVI2006Proceedings (redaktörskap) (Övrig (populärvetenskap, debatt, mm))
  • 144.
    Manns, Fabrice
    et al.
    Bascom Palmer Eye Institute, Miami, FL, USa.
    Söderberg, Per GUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.Ho, ArthurVision CRC, UNSW, SYDNEY, AUSTRALIA.
    Ophthalmic Technologies XVIII2008Proceedings (redaktörskap) (Övrigt vetenskapligt)
  • 145.
    Manns, Fabrice
    et al.
    Bascom Palmer Eye Institute, Miami University.
    Söderberg, PerUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.Ho, ArthurInstitute for Eye Research, Ltd, Australia .
    Ophthalmic Technologies XXI2011Proceedings (redaktörskap) (Refereegranskat)
  • 146. Manns, Manns
    et al.
    Ho, ArthurSöderberg, PerUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
    Ophthalmic Technologies XXIII2013Proceedings (redaktörskap) (Refereegranskat)
  • 147.
    Manns, Manns
    et al.
    University of Miami, Dept. of Biomedical Engineering, FL, USA.
    Ho, ArthurBrien Holden Vision Institute, Australia.Söderberg, PerUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Ophthalmic Technologies XXIX2019Proceedings (redaktörskap) (Refereegranskat)
  • 148.
    Manns, Manns
    et al.
    University of Miami, Dept. of Biomedical Engineering.
    Ho, ArthurSöderberg, PerUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Ophthalmic Technologies XXVII2017Proceedings (redaktörskap) (Refereegranskat)
  • 149.
    Manns, Manns
    et al.
    University of Miami, Dept. of Biomedical Engineering.
    Ho, ArthurBrien Holden Vision Institute, Sydney, Australia.Söderberg, PerUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Söderberg: Oftalmiatrik.
    Ophthalmic Technologies XXX2020Proceedings (redaktörskap) (Refereegranskat)
  • 150.
    Manns, Manns
    et al.
    Deprtment of Biomedical Engineering, University of Miami, FL.
    Söderberg, PerUppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.Ho, ArthurBrian Holden Vision Institue, Sidney University.
    Ophthalmic Technologies XXIV2014Proceedings (redaktörskap) (Refereegranskat)
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