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  • 101.
    Sorokin, Shirley J.
    et al.
    South Australian Museum, Adelaide, SA, Australia;SARDI Aquat Sci, 2 Hamra Ave, West Beach, SA, Australia.
    Ekins, Merrick G.
    Queensland Museum, Southbank, Qld, Australia;Univ Queensland, Sch Biol Sci, St Lucia, Qld, Australia.
    Yang, Qi
    Shanghai Jiao Tong Univ, State Key Lab Oncogene & Related Genes, Ctr Marine Drugs, Renji Hosp,Sch Med,Dept Pharm, Shanghai, Peoples R China;Flinders Univ S Australia, Coll Med & Publ Hlth, Ctr Marine Bioprod Dev, Adelaide, SA, Australia.
    Cárdenas, Paco
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi. Avignon Univ, Aix Marseille Univ, Inst Mediterraneen Biodiversite & Ecol Marine & C, CNRS,IRD,Stn Marine Endoume, Chemin Batterie Lions, F-13007 Marseille, France.
    A new deep-water Tethya (Porifera, Tethyida, Tethyidae) from the Great Australian Bight and an updated Tethyida phylogeny2019Ingår i: EUROPEAN JOURNAL OF TAXONOMY, ISSN 2118-9773, Vol. 529, s. 1-26Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A new species of Tethya Lamarck, 1815 is described from a depth of 1000 m on the continental slope of the Great Australian Bight (GAB), southern Australia. The GAB slope was explored as part of systematic benthic surveys to understand unexplored communities in the light of current oil and gas exploration activity in the area. Tethya irisae sp. nov. was present at 1000 m in six of eight longitudinal depth surveys. Three molecular markers were obtained: COI, 28S (D3-D5) and ITS1-5.8S-ITS2. COI and 28S phylogenetic analyses show that the new species fits clearly within the genus Tethya. This is the 28th species of Tethya reported from Australia; it is unusual in that it has a stalk. The presence of a stalk as a morphological character to split genera in this family is questioned. The description of this new species is an opportunity to revisit the molecular phylogeny of the Tethyida Morrow & Cardenas, 2015 using comprehensive datasets of COI and 28S markers. As in previous analyses, four Tethya clades were retrieved; we discuss the possibility of using external colour to support some of these clades. Despite unclear phylogenetic relationships amongst Tethyidae Gray, 1848 from Australia, our results suggest that tethyid genera Tethytimea Laubenfels, 1936, Tectitethya Sara, 1994, Laxotethya Sara & Sara, 2002, Stellitethya Sara, 1994, and Xenospongia Gray, 1858 derive from species of Tethya. We show that asters have been secondarily lost at least twice in the Hemiasterellidae Lendenfeld, 1889: in Liosina Thiele, 1899 and a potential new genus from northern Australia. We formally propose the reallocation of Liosina from Dictyonellidae van Soest, Diaz & Pomponi, 1990 to Hemiasterellidae Lendenfeld, 1889.

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  • 102.
    Strömstedt, Adam A.
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Vikeved, Elisabet
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Cárdenas, Paco
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Systematisk biologi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Alsmark, Cecilia
    Uppsala universitet.
    Chen, Yung Hsuan
    National Museum of Marine Biology and Aquarium.
    Backlund, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Aaptamines from Haliclona and bromopyrroles from Agelas — marine sponge alkaloids with distinct modes of action against bacteria and protozoaManuskript (preprint) (Övrigt vetenskapligt)
  • 103.
    Taboada, Sergi
    et al.
    Univ Autonoma Madrid, Fac Ciencias, Dept Biol Zool, Madrid 28049, Spain;Nat Hist Museum, Life Sci Dept, Cromwell Rd, London SW7 5BD, England;Univ Alcala De Henares, Dept Ciencias La Vida, Apdo 20, Alcala De Henares 28805, Spain.
    Silva, Ana Serra
    Nat Hist Museum, Life Sci Dept, Cromwell Rd, London SW7 5BD, England;UCL, Div Biosci, Gower St, London WC1E 6BT, England;Univ Bristol, Sch Earth Sci, Queens Rd, Bristol BS8 1RJ, Avon, England.
    Neal, Lenka
    Nat Hist Museum, Life Sci Dept, Cromwell Rd, London SW7 5BD, England.
    Cristobo, Javier
    Univ Alcala De Henares, Dept Ciencias La Vida, Apdo 20, Alcala De Henares 28805, Spain;Ctr Oceanog Gijon, Inst Espanol Oceanog, C Principe Asturias 70 Bis, Gijon 33212, Asturias, Spain.
    Rios, Pilar
    Univ Alcala De Henares, Dept Ciencias La Vida, Apdo 20, Alcala De Henares 28805, Spain;Ctr Oceanog Santander, Inst Espanol Oceanog, Promontorio San Martin S-N,Apdo 240, Santander 39080, Spain.
    Alvarez-Campos, Patricia
    Univ Autonoma Madrid, Fac Ciencias, Dept Biol Zool, Madrid 28049, Spain.
    Hestetun, Jon Thomassen
    NORCE Norwegian Res Ctr, NORCE Environm, PB 22, N-5838 Bergen, Norway.
    Koutsouveli, Vasiliki
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi. Nat Hist Museum, Life Sci Dept, Cromwell Rd, London SW7 5BD, England.
    Sherlock, Emma
    Nat Hist Museum, Life Sci Dept, Cromwell Rd, London SW7 5BD, England.
    Riesgo, Ana
    Nat Hist Museum, Life Sci Dept, Cromwell Rd, London SW7 5BD, England.
    Insights into the symbiotic relationship between scale worms and carnivorous sponges (Cladorhizidae, Chondrocladia)2020Ingår i: Deep Sea Research Part I: Oceanographic Research Papers, ISSN 0967-0637, E-ISSN 1879-0119, Vol. 156, artikel-id 103191Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Symbiotic associations between polynoid scale worms and other marine invertebrates are common, but sometimes poorly understood. Compounding this problem is the fact that polynoid systematics is largely unresolved. Here, we transfer the species originally described as Nemidia antillicola chondrocladiae Fauvel (1943), and currently synonymized with Neopolynoe acanellae (Verrill, 1881), to the species Neopolynoe chondrocladiae n. comb. This species is characterized by living in association with the carnivorous sponges Chondrocladia robertballnrdi Cristobo, Rios, Pomponi & Xavier, 2015 and Chondrocladia virgata Thompson, 1873. The existence of specialized chaetae in N. chondrocladiae n. comb. and the occurrence of open galleries in the sponge, derived from a gradual overgrowth of the sponge to accommodate the worm, suggest an obligate symbiotic relationship between worm and sponge. The presence of a gravid female with relatively small oocytes (maximum diameter 56.94 +/- 14.89 mu m) suggests that N. chondrocladiae n. comb. is a gonochoristic broadcaster with a planktotrophic larva, a means of reproduction that would maximize the chances of this species finding new suitable hosts to colonize. We also provide a phylogenetic placement, using four genetic markers (18S, 28S, 16S and COI), for N. chondrocladiae n. comb. and N. acanellae, which confirms they are two different species. In addition, we also report here the occurrence of another deep-water polynoid species in association with the carnivorous sponge Chondrocladia vertical= Topsent, 1920, from the Gulf of Mexico, and place it in a phylogeny.

  • 104.
    Ujan, Rabail
    et al.
    Univ Sindh, Dr MA Kazi Inst Chem, Jamshoro 76080, Pakistan.
    Saeed, Aamer
    Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
    Channar, Pervaiz Ali
    Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
    Larik, Fayaz Ali
    Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
    Abbas, Qamar
    Univ Sindh, Dept Physiol, Jamshoro 76080, Pakistan.
    Alajmi, Mohamed F.
    King Saud Univ, Dept Pharmacognosy, Coll Pharm, Riyadh 11451, Saudi Arabia.
    El-Seedi, Hesham
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Rind, Mahboob Ali
    Univ Sindh, Dr MA Kazi Inst Chem, Jamshoro 76080, Pakistan.
    Hassan, Mubashir
    Kongju Natl Univ, Coll Nat Sci, Dept Biol Sci, Gongju 314701, Chungnam, South Korea.
    Raza, Hussain
    Kongju Natl Univ, Coll Nat Sci, Dept Biol Sci, Gongju 314701, Chungnam, South Korea.
    Seo, Sung-Yum
    Kongju Natl Univ, Coll Nat Sci, Dept Biol Sci, Gongju 314701, Chungnam, South Korea.
    Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation2019Ingår i: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 24, nr 5, artikel-id 860Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A small library of new drug-1,3,4-thiazidazole hybrid compounds (3a-3i) was synthesized, characterized, and assessed for their acetyl cholinesterase enzyme (AChE) inhibitory and free radical scavenging activities. The newly synthesized derivatives showed promising activities against AChE, especially compound 3b (IC50 18.1 +/- 0.9 nM), which was the most promising molecule in the series, and was substantially more active than the reference drug (neostigmine methyl sulfate; IC50 2186.5 +/- 98.0 nM). Kinetic studies were performed to elucidate the mode of inhibition of the enzyme, and the compounds showed mixed-type mechanisms for inhibiting AChE. The Ki of 3b (0.0031 mu M) indicates that it can be very effective, even at low concentrations. Compounds 3a-3i all complied with Lipinski's Rule of Five, and showed high drug-likeness scores. The pharmacokinetic parameters revealed notable lead-like properties with insignificant liver and skin-penetrating effects. The structure-activity relationship (SAR) analysis indicated pi-pi interactions with key amino acid residues related to Tyr124, Trp286, and Tyr341.

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  • 105.
    Ul Haq, Faraz
    et al.
    Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan.
    Ali, Arslan
    Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan.
    Khan, Muhammad Noman
    Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan.
    Shah, Syed Muhammad Zaki
    Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan.
    Kandel, Ram Chandra
    Tribhuvan Univ, Cent Dept Chem, Kathmandu, Nepal.
    Aziz, Nudrat
    Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan.
    Adhikari, Achyut
    Tribhuvan Univ, Cent Dept Chem, Kathmandu, Nepal.
    Choudhary, M. Iqbal
    Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan;Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan;King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah 21452, Saudi Arabia.
    Atta-ur-Rahman,
    El-Seedi, Hesham
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi. Alrayan Med Coll, Medina 42541, Saudi Arabia.
    Musharraf, Syed Ghulam
    Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan;Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan.
    Metabolite Profiling and Quantitation of Cucurbitacins in Cucurbitaceae Plants by Liquid Chromatography coupled to Tandem Mass Spectrometry2019Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, artikel-id 15992Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Cucurbitaceae is an important plant family because many of its species are consumed as food, and used in herbal medicines, cosmetics, etc. It comprises annual vines and is rich in various bioactive principles which include the cucurbitacins. These steroidal natural products, derived from the triterpene cucurbitane, are mainly the bitter principles of the family Cucurbitaceae. Their biological activities include anti-inflammatory, hepatoprotective, and anti-cancer activities. A total of 10 species belonging to 6 genera of the Cucurbitaceae family along with Cissampelos pareira (Menispermaceae) were included in this study. A comprehensive profiling of certain natural products was developed using HPLC-QTOF-MS/MS analysis and a distribution profile of several major natural products in this family was obtained. A total of 51 natural products were detected in both positive and negative ionization modes, based on accurate masses and fragmentation patterns. Along with this, quantitation of four bioactive cucurbitacins, found in various important plants of the Cucurbitaceae family, was carried out using multiple reaction monitoring (MRM) approach on an ion trap mass spectrometer. Cucurbitacin Q was found to be the most abundant in C. pareira, while Citrullus colocynthis contained all four cucurbitacins in abundant quantities. The developed quantitation method is simple, rapid, and reproducible.

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  • 106.
    Vacelet, Jean
    et al.
    IMBE, CNRS, Aix Marseille Univ, Univ Avignon, IRD, Station Marine d’Endoume, Marseille, France.
    Cárdenas, Paco
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi. IMBE, CNRS, Aix Marseille Univ, Univ Avignon, IRD, Station Marine d’Endoume, Marseille, France.
    When is an aster not an aster? A new deep-sea Discorhabdella (Demospongiae, Poecilosclerida) with asters, from the Mozambique Channel2018Ingår i: Zootaxa, ISSN 1175-5326, E-ISSN 1175-5334, Vol. 4466, nr 1, s. 197-204Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Discorhabdella pseudaster n. sp. is an incrusting sponge from the upper bathyal zone of the 'Banc du Geyser', north of Madagascar, Mozambique Channel. This new species is described only from a single specimen but it is remarkable by the presence of spicules similar to euasters, a type of microsclere unknown in Poecilosclerida. These spicules are in fact a new example of homoplasy, being derivatives of the typical Discorhabdella pseudoastrose acanthostyles, which are here reduced to the aster-like tyles. The isochelae with a large lamella on the shaft are also quite unique in Poeciloclerida.

  • 107.
    Vikeved, Elisabet
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Alsmark, UCM
    Uppsala universitet.
    Sköld, Christian
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi.
    Prediction of anti-leishmanial drug targets using metabolite-based target fishingManuskript (preprint) (Övrigt vetenskapligt)
  • 108.
    Vikeved, Elisabet
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Buonfiglio, R.
    AstraZeneca R&D Gothenburg, Chem Innovat Ctr, Discovery Sci, SE-43183 Molndal, Sweden..
    Kogej, T.
    AstraZeneca R&D Gothenburg, Chem Innovat Ctr, Discovery Sci, SE-43183 Molndal, Sweden..
    Backlund, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Mapping metabolic pathways in chemical property space paves the way for new leishmanicidals2016Ingår i: Planta Medica, ISSN 0032-0943, E-ISSN 1439-0221, Vol. 82Artikel i tidskrift (Övrigt vetenskapligt)
  • 109.
    Vikeved, Elisabet
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Sköld, Christian
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi.
    Alsmark, UCM
    Uppsala universitet.
    Multi-targeting the folate pathway is a promising strategy against Leishmania tropicaManuskript (preprint) (Övrigt vetenskapligt)
  • 110.
    Wang, Yan
    et al.
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Lloyd, Katy A.
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Gunasekera, Sunithi
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Eriksson, Camilla
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Ramsköld, Daniel
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Lundberg, Karin
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Jakobsson, Per-Johan
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Göransson, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Malmström, Vivianne
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Grönwall, Caroline
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG2018Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift (Övrigt vetenskapligt)
  • 111.
    Wu, Di
    et al.
    Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China..
    Tu, Maolin
    Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China..
    Wang, Zhenyu
    Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China..
    Wu, Chao
    Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China..
    Yu, Cuiping
    Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China..
    Battino, Maurizio
    Univ Vigo, Dept Analyt & Food Chem, Nutr & Food Sci Grp, CITACA,CACTI, Vigo Campus, Vigo, Spain..
    El-Seedi, Hesham
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Du, Ming
    Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China..
    Biological and conventional food processing modifications on food proteins: Structure, functionality, and bioactivity2020Ingår i: Biotechnology Advances, ISSN 0734-9750, E-ISSN 1873-1899, Vol. 40, artikel-id 107491Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Food proteins are important nutrients for human health and thus make significant contributions to the unique functions of different foods. The modification of proteins through physical and biological processing could improve the functional and nutritional properties of food products; these changes can be attributed to modifications in particle size, solubility, emulsion stability, secondary structure, as well as the bioactivities of the proteins. Physical processing treatments might promote physical phenomena, such as combined friction, collision, shear forces, turbulence, and cavitation of particles, and lead to changes in the particle sizes of proteins. The objective of this review is to illustrate the effect of physical and biological processing on the structure, and physical and chemical properties of food-derived proteins and provide insights into the mechanism underlying structural changes. Many studies have suggested that physical and biological processes, such as ultrasound treatment, high pressure homogenization, ball mill treatment, and enzymatic hydrolysis could affect the structure, physical properties, and chemical properties of food-derived proteins. Some important applications of food-derived proteins are also discussed based on the relationships between their physical, chemical, and functional properties. Perspectives from fundamental or practical research are also brought in to provide a complete picture of the currently available relevant data.

  • 112. Xiang, Chun‐Lei
    et al.
    Dong, Hong‐Jin
    Landrein, Sven
    Zhao, Fei
    Yu, Wen‐Bin
    Soltis, Douglas E.
    Soltis, Pamela S.
    Backlund, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Wang, Hua‐Feng
    Li, De‐Zhu
    Peng, Hua
    Revisiting the phylogeny of Dipsacales: New insights from phylogenomic analyses of complete plastomic sequences2019Ingår i: Journal of Systematics and Evolution, ISSN 1674-4918, E-ISSN 1759-6831Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Phylogenetic relationships in Dipsacales have long been a major challenge. Although considerable progress has been made during the past two decades, questions remain; the uncertain systematic positions of HeptacodiumTriplostegia, and Zabelia, in particular, impede our understanding of Dipsacales evolution. Here we use 75 complete plastomic sequences to reconstruct the phylogeny of Dipsacales, of which 28 were newly generated. Two primary clades were recovered that form the phylogenetic backbone of Dipsacales. Seven of the primary clades correspond to the recognized families Adoxaceae, Caprifoliaceae s. str., Diervillaceae, Dipsacaceae, Linnaeaceae, Morinaceae, and Valerianaceae, and one corresponds to Zabelia, which was found to be the closest relative of Morinaceae in all analyses. Additionally, our results, with greatly increased confidence in most branches, show that Heptacodium and Triplostegia are members of Caprifoliaceae s. str. and Dipsacaceae, respectively. The results of our study indicate that the complete plastomic sequences provide a fully‐resolved and well‐supported representation of the phylogenetic relationships within Dipsacales.

  • 113.
    Xu, Jing-Hao
    et al.
    Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 94450, Taiwan;Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan.
    Lai, Kuei-Hung
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi. Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan.
    Su, Yin-Di
    Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan;Ind Technol Res Inst, Greenhouse Syst Technol Ctr, Cent Reg Campus, Nantou 54041, Taiwan.
    Chang, Yu-Chia
    Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan;Ind Technol Res Inst, Greenhouse Syst Technol Ctr, Cent Reg Campus, Nantou 54041, Taiwan;Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan.
    Peng, Bo-Rong
    Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan;Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 80424, Taiwan;Acad Sinica, Doctoral Degree Program Marine Biotechnol, Taipei 11529, Taiwan.
    Backlund, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Wen, Zhi-Hong
    Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan.
    Sung, Ping-Jyun
    Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 94450, Taiwan;Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan;Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan;China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40447, Taiwan;Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.
    Briaviolides K-N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum2018Ingår i: Marine Drugs, ISSN 1660-3397, E-ISSN 1660-3397, Vol. 16, nr 3, artikel-id 75Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Four new briarane diterpenoids, briaviolides K-N (1-4), have been obtained from the cultured-type octocoral Briareum violaceum. Using a spectroscopic approach, the structures of briaranes 1-4 were identified. This study employed an in vitro model of lipopolysaccharide (LPS)-induced inflammation in the murine macrophage RAW264.7 cell line, and found that among the four briaranes, briarane 2 possessed anti-inflammatory activity against inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions in cells. In addition, principal component analysis using the chemical global positioning system (ChemGPS) for natural products (ChemGPS-NP) was employed in order to analyze the structure-activity relationship (SAR), and the results indicated that the ring conformation of the compound has a leading role in suppressing the expressions of pro-inflammatory iNOS and COX-2 proteins in macrophages.

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  • 114.
    Yang, L.
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi. China Pharmaceut Univ, Dept Complex Prescript TCM, Jiangsu Prov Key Lab TCM Evaluat & Translat Res, Nanjing, Jiangsu, Peoples R China..
    Henz, Astrid
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Backlund, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Predicting inhibitors of HSP27 phosphorylation using ChemGPS-NP2016Ingår i: Planta Medica, ISSN 0032-0943, E-ISSN 1439-0221, Vol. 82Artikel i tidskrift (Övrigt vetenskapligt)
  • 115.
    Zahra, Maram Hussein
    et al.
    Okayama Univ, Grad Sch Nat Sci & Technol, Div Chem & Biotechnol, Okayama 7008530, Japan.
    Salem, Tarek A. R.
    Qassim Univ, Dept Biochem, Coll Med, Al Qassim 51452, Saudi Arabia;Univ Sadat City, Genet Engn & Biotechnol Inst, Dept Mol Biol, Sadat City 32958, Egypt.
    El-Aarag, Bishoy
    Okayama Univ, Grad Sch Nat Sci & Technol, Div Chem & Biotechnol, Okayama 7008530, Japan;Menoufia Univ, Div Biochem, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt.
    Yosri, Nermeen
    Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt.
    EL-Ghlban, Samah
    Menoufia Univ, Div Biochem, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt.
    Zaki, Kholoud
    Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt.
    Marei, Amel H.
    Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt.
    Abd El-Wahed, Aida
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi. Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt;Agr Res Ctr, Plant Protect Res Inst, Dept Bee Res, Giza 12627, Egypt.
    Saeed, Aamer
    Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
    Khatib, Alfi
    Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Fac Pharm, Kuantan 25200, Pahang, Malaysia.
    AlAjmi, Mohamed F.
    King Saud Univ, Coll Pharm, Pharmacognosy Grp, Riyadh 11451, Saudi Arabia.
    Shathili, Abdulrahman M.
    Al Rayan Coll, Al Rayan Res & Innovat Ctr, Medina 42541, Saudi Arabia.
    Xiao, Jianbo
    Univ Macau, Inst Chinese Med Sci, Taipa 999078, Macau, Peoples R China.
    Khalifa, Shaden A. M.
    Karolinska Univ Hosp, Clin Res Ctr, S-14186 Huddinge, Sweden;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, SE-10691 Stockholm, Sweden.
    El-Seedi, Hesham
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi. Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt;Al Rayan Coll, Al Rayan Res & Innovat Ctr, Medina 42541, Saudi Arabia;Jiangsu Univ, Coll Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.
    Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities2019Ingår i: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 24, nr 13, artikel-id 2495Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background/Aim: Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers.

    Methods: The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model.

    Results: A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, H-1-NMR and C-13-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 mu g/mL, respectively.

    Conclusion: Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet.

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  • 116. Zahran, Moustafa
    et al.
    El-Kemary, Maged
    Khalifa, Shaden
    El-Seedi, Hesham
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Spectral studies of silver nanoparticles biosynthesized by Origanum majorana2018Ingår i: Green Processing and Synthesis, ISSN 2191-9542, E-ISSN 2191-9550, Vol. 7, nr 2, s. 100-105Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Silver nanoparticles (AgNPs) were biologically synthesized in an eco-friendly manner using aqueous leaf extract of Origanum majorana plant and silver nitrate (AgNO 3) solution. Size, shape, and crystallinity of the biosynthesized AgNPs were determined by using a transmission electron microscope (TEM). Zeta potential analyzer was used to prove the stability of the metallic nanoparticles, while Fourier transform infrared spectroscopy was used to identify the bioreducing and capping agents. AgNPs were electrochemically investigated using cyclic voltammetry (CV), while the optical properties of the metallic nanoparticles were studied using UV-Vis and fluorescence spectroscopies. According to TEM images, AgNPs are spherical with an average size of 35 nm. TEM also refers to the presence of mono and polycrystalline AgNPs. The value of zeta potential (-39 mV) proved the stability of AgNPs caused by capping molecules of O. majorana plant. CV studies showed that AgNPs were electrochemically investigated at 0.39 mV. AgNPs showed a surface plasmon resonance peak at 440 nm, while the emission peak was detected at 466 nm. These nanoparticles are promising for many industrial and medical applications.

  • 117.
    Zumberge, J. Alex
    et al.
    Univ Calif Riverside, Dept Earth Sci, Riverside, CA 92521 USA.
    Love, Gordon D.
    Univ Calif Riverside, Dept Earth Sci, Riverside, CA 92521 USA.
    Cárdenas, Paco
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Sperling, Erik A.
    Stanford Univ, Dept Geol Sci, Stanford, CA 94305 USA.
    Gunasekera, Sunithi
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Rohrssen, Megan
    Cent Michigan Univ, Dept Earth & Atmospher Sci, Mt Pleast, MI USA.
    Grosjean, Emmanuelle
    Geosci Australia, Canberra, ACT, Australia.
    Grotzinger, John P.
    CALTECH, Div Geol & Planetary Sci, Pasadena, CA USA.
    Summons, Roger E.
    MIT, Dept Earth Atmospher & Planetary Sci, Cambridge, MA USA.
    Demosponge steroid biomarker 26-methylstigmastane provides evidence for Neoproterozoic animals2018Ingår i: Nature Ecology & Evolution, E-ISSN 2397-334X, Vol. 2, nr 11, s. 1709-1714Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Sterane biomarkers preserved in ancient sedimentary rocks hold promise for tracking the diversification and ecological expansion of eukaryotes. The earliest proposed animal biomarkers from demosponges (Demospongiae) are recorded in a sequence around 100 Myr long of Neoproterozoic-Cambrian marine sedimentary strata from the Huqf Supergroup, South Oman Salt Basin. This C-30 sterane biomarker, informally known as 24-isopropylcholestane (24-ipc), possesses the same carbon skeleton as sterols found in some modern-day demosponges. However, this evidence is controversial because 24-ipc is not exclusive to demosponges since 24-ipc sterols are found in trace amounts in some pelagophyte algae. Here, we report a new fossil sterane biomarker that co-occurs with 24-ipc in a suite of late Neoproterozoic-Cambrian sedimentary rocks and oils, which possesses a rare hydrocarbon skeleton that is uniquely found within extant demosponge taxa. This sterane is informally designated as 26-methylstigmastane (26-mes), reflecting the very unusual methylation at the terminus of the steroid side chain. It is the first animal-specific sterane marker detected in the geological record that can be unambiguously linked to precursor sterols only reported from extant demosponges. These new findings strongly suggest that demosponges, and hence multicellular animals, were prominent in some late Neoproterozoic marine environments at least extending back to the Cryogenian period.

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