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  • 151.
    Johansson, Martin M.
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Van Geystelen, Anneleen
    Larmuseau, Maarten H. D.
    Djurovic, Srdjan
    Andreassen, Ole A.
    Agartz, Ingrid
    Jazin, Elena
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Microarray Analysis of Copy Number Variants on the Human Y Chromosome Reveals Novel and Frequent Duplications Overrepresented in Specific Haplogroups2015Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, nr 8, artikel-id e0137223Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND:

    The human Y chromosome is almost always excluded from genome-wide investigations of copy number variants (CNVs) due to its highly repetitive structure. This chromosome should not be forgotten, not only for its well-known relevance in male fertility, but also for its involvement in clinical phenotypes such as cancers, heart failure and sex specific effects on brain and behaviour.

    RESULTS:

    We analysed Y chromosome data from Affymetrix 6.0 SNP arrays and found that the signal intensities for most of 8179 SNP/CN probes in the male specific region (MSY) discriminated between a male, background signals in a female and an isodicentric male containing a large deletion of the q-arm and a duplication of the p-arm of the Y chromosome. Therefore, this SNP/CN platform is suitable for identification of gain and loss of Y chromosome sequences. In a set of 1718 males, we found 25 different CNV patterns, many of which are novel. We confirmed some of these variants by PCR or qPCR. The total frequency of individuals with CNVs was 14.7%, including 9.5% with duplications, 4.5% with deletions and 0.7% exhibiting both. Hence, a novel observation is that the frequency of duplications was more than twice the frequency of deletions. Another striking result was that 10 of the 25 detected variants were significantly overrepresented in one or more haplogroups, demonstrating the importance to control for haplogroups in genome-wide investigations to avoid stratification. NO-M214(xM175) individuals presented the highest percentage (95%) of CNVs. If they were not counted, 12.4% of the rest included CNVs, and the difference between duplications (8.9%) and deletions (2.8%) was even larger.

    CONCLUSIONS:

    Our results demonstrate that currently available genome-wide SNP platforms can be used to identify duplications and deletions in the human Y chromosome. Future association studies of the full spectrum of Y chromosome variants will demonstrate the potential involvement of gain or loss of Y chromosome sequence in different human phenotypes.

  • 152.
    Johansson, Martin
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Pottmeier, Philipp
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Suciu, Pascalina
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Ahmed, Tauseef
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Zaghlool, Ammar
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik.
    Halvardson, Jonatan
    Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Darj, Elisabeth
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH), Internationell kvinno- och mödrahälsovård och migration. Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Trondheim, Norway.
    Feuk, Lars
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik.
    Peuckert, Christiane
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Stockholms Univ, Dept Mol Biol, Stockholm, Sweden.
    Jazin, Elena
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Novel Y-Chromosome Long Non-Coding RNAs Expressed in Human Male CNS During Early Development2019Ingår i: Frontiers in Genetics, ISSN 1664-8021, E-ISSN 1664-8021, Vol. 10, artikel-id 891Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Global microarray gene expression analyses previously demonstrated differences in female and male embryos during neurodevelopment. In particular, before sexual maturation of the gonads, the differences seem to concentrate on the expression of genes encoded on the X- and Y-chromosomes. To investigate genome-wide differences in expression during this early developmental window, we combined high-resolution RNA sequencing with qPCR to analyze brain samples from human embryos during the first trimester of development. Our analysis was tailored for maximum sensitivity to discover Y-chromosome gene expression, but at the same time, it was underpowered to detect X-inactivation escapees. Using this approach, we found that 5 out of 13 expressed game to log pairs showed unbalanced gene dosage, and as a consequence, a male-biased expression. In addition, we found six novel non-annotated long non-coding RNAs on the Y-chromosome with conserved expression patterns in newborn chimpanzee. The tissue specific and time-restricted expression of these long non-coding RNAs strongly suggests important functions during central nervous system development in human males.

  • 153.
    Juras, Anna
    et al.
    Adam Mickiewicz Univ, Inst Anthropol, Dept Human Evolutionary Biol, Fac Biol, Umultowska 89, PL-61614 Poznan, Poland..
    Chylenski, Maciej
    Adam Mickiewicz Univ, Inst Prehist, Fac Hist, Umultowska 89D, PL-61614 Poznan, Poland..
    Krenz-Niedbala, Marta
    Adam Mickiewicz Univ, Inst Anthropol, Dept Human Evolutionary Biol, Fac Biol, Umultowska 89, PL-61614 Poznan, Poland..
    Malmström, Helena
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Ehler, Edvard
    Adam Mickiewicz Univ, Inst Anthropol, Dept Human Evolutionary Biol, Fac Biol, Umultowska 89, PL-61614 Poznan, Poland..
    Pospieszny, Lukasz
    Polish Acad Sci, Inst Archaeol & Ethnol, Rubiez 46, PL-61612 Poznan, Poland..
    Lukasik, Sylwia
    Adam Mickiewicz Univ, Inst Anthropol, Dept Human Evolutionary Biol, Fac Biol, Umultowska 89, PL-61614 Poznan, Poland..
    Bednarczyk, Jozef
    Adam Mickiewicz Univ, Inst Prehist, Fac Hist, Umultowska 89D, PL-61614 Poznan, Poland..
    Piontek, Janusz
    Adam Mickiewicz Univ, Inst Anthropol, Dept Human Evolutionary Biol, Fac Biol, Umultowska 89, PL-61614 Poznan, Poland..
    Jakobsson, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Dabert, Miroslawa
    Adam Mickiewicz Univ, Mol Biol Techn Lab, Fac Biol, Umultowska 89, PL-61614 Poznan, Poland..
    Investigating kinship of Neolithic post-LBK human remains from Krusza Zamkowa, Poland using ancient DNA2017Ingår i: Forensic Science International: Genetics, ISSN 1872-4973, E-ISSN 1878-0326, Vol. 26, s. 30-39Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We applied an interdisciplinary approach to investigate kinship patterns and funerary practices during the middle Neolithic. Genetic studies, radiocarbon dating, and taphonomic analyses were used to examine two grave clusters from Krusza Zamkowa, Poland. To reconstruct kinship and determine biological sex, we extracted DNA from bones and teeth, analyzed mitochondrial genomes and nuclear SNPs using the HID-Ion AmpliSeq (TM) Identity panel generated on Illumina and Ion Torrent platforms, respectively. We further dated the material (AMS C-14) and to exclude aquatic radiocarbon reservoir effects, measures of carbon and nitrogen stable isotopes for diet reconstruction were used. We found distinct mitochondrial genomes belonging to haplogroups U5b2a1a, K1c and H3d in the first grave cluster, and excluded maternal kin patterns among the three analyzed individuals. In the second grave cluster one individual belonged to K1a4. However, we could not affiliate the second individual to a certain haplogroup due to the fragmented state of the mitochondrial genome. Although the individuals from the second grave cluster differ at position 6643, we believe that more data is needed to fully resolve this issue. We retrieved between 26 and 77 autosomal SNPs from three of the individuals. Based on kinship estimations, taking into account the allelic dropout distribution, we could not exclude first degree kin relation between the two individuals from the second grave cluster. We could, however, exclude a first degree kinship between these two individuals and an individual from the first grave cluster. Presumably, not only biological kinship, but also social relations played an important role in the funerary practice during this time period. We further conclude that the HID-Ion AmpliSeq (TM) Identity Panel may prove useful for first degree kin relation studies for samples with good DNA preservation, and that mitochondrial genome capture enrichment is a powerful tool for excluding direct maternal relationship in ancient individuals.

  • 154.
    Kalf, R.
    et al.
    Natl Healthcare Inst ZIN, Diemen, Netherlands..
    Makady, A.
    Natl Healthcare Inst ZIN, Diemen, Netherlands..
    Ryll, Bettina
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Melanoma Patient Network Europe, Uppsala, Sweden..
    Spurrier, G.
    Melanoma Patient Network Europe, Uppsala, Sweden.;Melanome France, Uppsala, Sweden..
    Goettsch, W.
    Natl Hlth Care Inst, Diemen, Netherlands..
    Social Media: A Valuable Tool To Assess Patient Perspectives Regarding Quality Of Life2016Ingår i: Value in Health, ISSN 1098-3015, E-ISSN 1524-4733, Vol. 19, nr 7, s. A749-A749Artikel i tidskrift (Refereegranskat)
  • 155. Khonsari, R. H.
    et al.
    Olivier, J.
    Vigneaux, P.
    Sanchez, S.
    Tafforeau, P.
    Ahlberg, Per E.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Di Rocco, F.
    Bresch, D.
    Corre, P.
    Ohazama, A.
    Sharpe, P. T.
    Calvez, V.
    A mathematical model for mechanotransduction at the early steps of suture formation2013Ingår i: Proceedings of the Royal Society of London. Biological Sciences, ISSN 0962-8452, E-ISSN 1471-2954, Vol. 280, nr 1759, s. 20122670-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Growth and patterning of craniofacial sutures is subjected to the effects of mechanical stress. Mechanotransduction processes occurring at the margins of the sutures are not precisely understood. Here, we propose a simple theoretical model based on the orientation of collagen fibres within the suture in response to local stress. We demonstrate that fibre alignment generates an instability leading to the emergence of interdigitations. We confirm the appearance of this instability both analytically and numerically. To support our model, we use histology and synchrotron X-ray microtomography and reveal the fine structure of fibres within the sutural mesenchyme and their insertion into the bone. Furthermore, using a mouse model with impaired mechanotransduction, we show that the architecture of sutures is disturbed when forces are not interpreted properly. Finally, by studying the structure of sutures in the mouse, the rat, an actinopterygian (Polypterus bichir) and a placoderm(Compagopiscis croucheri), we show that bone deposition patterns during dermal bone growth are conserved within jawed vertebrates. In total, these results support the role of mechanical constraints in the growth and patterning of craniofacial sutures, a process that was probably effective at the emergence of gnathostomes, and provide new directions for the understanding of normal and pathological suture fusion.

  • 156.
    Kilinc, Gülsah Merve
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey..
    Omrak, Ayca
    Stockholm Univ, Dept Archaeol & Class Studies, Lilla Frescativaegen 7, S-11418 Stockholm, Sweden..
    Ozer, Fusun
    Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey..
    Günther, Torsten
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Buyukkarakaya, Ali Metin
    Hacettepe Univ, Dept Anthropol, TR-06800 Ankara, Turkey..
    Bicakci, Erhan
    Istanbul Univ, Dept Prehist, TR-34134 Istanbul, Turkey..
    Baird, Douglas
    Univ Liverpool, Dept Archaeol Class & Egyptol, Liverpool L69 7WZ, Merseyside, England..
    Donertas, Handan Melike
    Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey..
    Ghalichi, Ayshin
    Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey..
    Yaka, Reyhan
    Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey..
    Koptekin, Dilek
    Middle East Tech Univ, Dept Hlth Informat, TR-06800 Ankara, Turkey..
    Acan, Sinan Can
    Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey..
    Parvizi, Poorya
    Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey..
    Krzewinska, Maja
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Daskalaki, Evangelia A.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Stockholm Univ, Dept Archaeol & Class Studies, Lilla Frescativaegen 7, S-11418 Stockholm, Sweden..
    Yuncu, Eren
    Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey..
    Dagtas, Nihan Dilsad
    Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey..
    Fairbairn, Andrew
    Univ Queensland, Sch Social Sci, Brisbane, Qld 4072, Australia..
    Pearson, Jessica
    Univ Liverpool, Dept Archaeol Class & Egyptol, Liverpool L69 7WZ, Merseyside, England..
    Mustafaoglu, Gokhan
    Bulent Ecevit Univ, Dept Archaeol, TR-67100 Incivez, Zonguldak, Turkey..
    Erdal, Yilmaz Selim
    Hacettepe Univ, Dept Anthropol, TR-06800 Ankara, Turkey..
    Cakan, Yasin Gokhan
    Istanbul Univ, Dept Prehist, TR-34134 Istanbul, Turkey..
    Togan, Inci
    Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey..
    Somel, Mehmet
    Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey..
    Stora, Jan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Jakobsson, Mattias
    Stockholm Univ, Dept Archaeol & Class Studies, Lilla Frescativaegen 7, S-11418 Stockholm, Sweden..
    Gotherstrom, Anders
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    The Demographic Development of the First Farmers in Anatolia2016Ingår i: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 26, nr 19, s. 2659-2666Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The archaeological documentation of the development of sedentary farming societies in Anatolia is not yet mirrored by a genetic understanding of the human populations involved, in contrast to the spread of farming in Europe [1-3]. Sedentary farming communities emerged in parts of the Fertile Crescent during the tenth millennium and early ninth millennium calibrated (cal) BC and had appeared in central Anatolia by 8300 cal BC [4]. Farming spread into west Anatolia by the early seventh millennium cal BC and quasi-synchronously into Europe, although the timing and process of this movement remain unclear. Using genome sequence data that we generated from nine central Anatolian Neolithic individuals, we studied the transition period from early Aceramic (Pre-Pottery) to the later Pottery Neolithic, when farming expanded west of the Fertile Crescent. We find that genetic diversity in the earliest farmers was conspicuously low, on a par with European foraging groups. With the advent of the Pottery Neolithic, genetic variation within societies reached levels later found in early European farmers. Our results confirm that the earliest Neolithic central Anatolians belonged to the same gene pool as the first Neolithic migrants spreading into Europe. Further, genetic affinities between later Anatolian farmers and fourth to third millennium BC Chalcolithic south Europeans suggest an additional wave of Anatolian migrants, after the initial Neolithic spread but before the Yamnaya-related migrations. We propose that the earliest farming societies demographically resembled foragers and that only after regional gene flow and rising heterogeneity did the farming population expansions into Europe occur.

  • 157. Klein, Hendrik
    et al.
    Niedzwiedzki, Grzegorz
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Voigt, Sebastian
    Lagnaoui, Abdelouahed
    Hminna, Abdelkbir
    Saber, Hafid
    Schneider, Joerg W.
    The Tetrapod Ichnogenus Protochirotherium Fichter and Kunz 2004, a Characteristic Early Triassic Morphotype of Central Pangea2013Ingår i: Ichnos, ISSN 1042-0940, E-ISSN 1563-5236, Vol. 20, nr 1, s. 24-30Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Early Triassic chirotherian footprint assemblages from Poland, Germany, and Morocco are important for understanding archosaur evolution in the aftermath of the Permian-Triassic crisis. However, their ichnotaxonomy is confusing because various authors have interpreted their diversity differently. After an analysis and ichnotaxonomic re-assessment, the presence of the ichnogenera Brachychirotherium, Isochirotherium, and Chirotherium in these assemblages is not supported. Distant similarities with these ichnotaxa are functions of extra morphological variation and substrate-related factors. Instead, Early Triassic chirotherian footprints described under these names are assigned here to the ichnogenus Protochirotherium and to a more slender morphotype identified as Synaptichnium. In particular, Protochirotherium appears to be more widely distributed in central Pangea as a characteristic morphotype reflecting a distinct stage in archosaur evolution. Trackmakers were nonarchosaurian archosauriforms or, alternatively, stem-group crocodylians. Morphologically and temporally these footprints match the hypothetical ancestor of the Chirotherium barthii trackmaker. Chirotherium barthii appears by the beginning of the Middle Triassic. Because of its restricted stratigraphic range, and its wider distribution in central Pangea, Protochirotherium also has biostratigraphic significance for this region and can be considered as an indicator of Early Triassic-aged strata.

  • 158.
    Knoll, Fabien
    et al.
    ARAID Fdn Conjunto Paleontol Teruel Dinopolis, Teruel 44002, Spain.;Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England..
    Chiappe, Luis M.
    Nat Hist Museum Los Angeles Cty, Dinosaur Inst, Los Angeles, CA 90007 USA. Uppsala Univ, Dept Organismal Biol, S-75236 Uppsala, Sweden..
    Sanchez, Sophie
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. European Synchrotron Radiat Facil, F-38000 Grenoble, France..
    Garwood, Russell J.
    Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England.;Nat Hist Museum, Dept Earth Sci, Cromwell Rd, London SW7 5BD, England..
    Edwards, Nicholas P.
    Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England.;SLAC Natl Accelerator Lab, Stanford Synchrotron Radiat Lightsource, Menlo Pk, CA 94025 USA..
    Wogelius, Roy A.
    Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England..
    Sellers, William I.
    Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England..
    Manning, Phillip L.
    Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England.;Coll Charleston, Dept Geol & Environm Geosci, Charleston, SC 29424 USA..
    Ortega, Francisco
    Univ Nacl Educ Distancia, Fac Ciencias, E-28040 Madrid, Spain..
    Serrano, Francisco J.
    Nat Hist Museum Los Angeles Cty, Dinosaur Inst, Los Angeles, CA 90007 USA. Uppsala Univ, Dept Organismal Biol, S-75236 Uppsala, Sweden.;Univ Malaga, Fac Ciencias, Malaga 29010, Spain..
    Marugan-Lobon, Jesus
    Nat Hist Museum Los Angeles Cty, Dinosaur Inst, Los Angeles, CA 90007 USA. Uppsala Univ, Dept Organismal Biol, S-75236 Uppsala, Sweden.;Univ Autonoma Madrid, Fac Ciencias, E-28049 Madrid, Spain..
    Cuesta, Elena
    Univ Autonoma Madrid, Fac Ciencias, E-28049 Madrid, Spain..
    Escaso, Fernando
    Univ Nacl Educ Distancia, Fac Ciencias, E-28040 Madrid, Spain..
    Luis Sanz, Jose
    Univ Autonoma Madrid, Fac Ciencias, E-28049 Madrid, Spain..
    A diminutive perinate European Enantiornithes reveals an asynchronous ossification pattern in early birds2018Ingår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, artikel-id 937Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Fossils of juvenile Mesozoic birds provide insight into the early evolution of avian development, however such fossils are rare. The analysis of the ossification sequence in these early-branching birds has the potential to address important questions about their comparative developmental biology and to help understand their morphological evolution and ecological differentiation. Here we report on an early juvenile enantiornithine specimen from the Early Cretaceous of Europe, which sheds new light on the osteogenesis in this most species-rich clade of Mesozoic birds. Consisting of a nearly complete skeleton, it is amongst the smallest known Mesozoic avian fossils representing post-hatching stages of development. Comparisons between this new specimen and other known early juvenile enantiornithines support a clade-wide asynchronous pattern of osteogenesis in the sternum and the vertebral column, and strongly indicate that the hatchlings of these phylogenetically basal birds varied greatly in size and tempo of skeletal maturation.

  • 159. Kullander, Sven O.
    et al.
    Stach, Thomas
    Hansson, Hans G.
    Delling, Bo
    Blom, Henning
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Nationalnyckeln till Sveriges Flora och Fauna: [DZ 1-34], Ryggsträngsdjur: lansettfiskar – broskfiskar : Chordata : Branchiostomatidae – Chondrichthyes2011Bok (Övrig (populärvetenskap, debatt, mm))
  • 160.
    Kundrát, Martin
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Univ Pavol Jozef Safarik, Ctr Interdisciplinary Biosci Technol & Innovat Pk, Kosice, Slovakia.
    Nudds, John
    Univ Manchester, Sch Earth & Environm Sci, Manchester, Lancs, England.
    Kear, Benjamin P.
    Uppsala universitet, Enheten för musik och museer, Evolutionsmuseet.
    Lu, Junchang
    Chinese Acad Geol Sci, Key Lab Stratig & Paleontol, Inst Geol, Minist Land Resources, Beijing, Peoples R China.
    Ahlberg, Per
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    The first specimen of Archaeopteryx from the Upper Jurassic Mornsheim Formation of Germany2019Ingår i: Historical Biology, ISSN 0891-2963, E-ISSN 1029-2381, Vol. 31, nr 1, s. 3-63Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    From an initial isolated position as the oldest evolutionary prototype of a bird, Archaeopteryx has, as a result of recent fossil discoveries, become embedded in a rich phylogenetic context of both more and less crownward stem-group birds. This has prompted debate over whether Archaeopteryx is simply a convergently bird-like non-avialan theropod. Here we show, using the first synchrotron microtomographic examination of the genus, that the eighth or Daiting specimen of Archaeopteryx possesses a character suite that robustly constrains it as a basal avialan (primitive bird). The specimen, which comes from the Mornsheim Formation and is thus younger than the other specimens from the underlying Solnhofen Formation, is distinctive enough to merit designation as a new species, Archaeopteryx albersdoerferi sp. nov., but is recovered in close phylogenetic proximity to Archaeopteryx lithographica. Skeletal innovations of the Daiting specimen, such as fusion and pneumatization of the cranial bones, well vascularized pectoral girdle and wing elements, and a reinforced configuration of carpals and metacarpals, suggest that it may have had more characters seen in flying birds than the older Archaeopteryx lithographica. These innovations appear to be convergent on those of more crownward avialans, suggesting that Bavarian archaeopterygids independently acquired increasingly bird-like traits over time. Such mosaic evolution and iterative exploration of adaptive space may be typical for major functional transitions like the origin of flight.

  • 161.
    Kundrát, Martin
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Sotak, Ján
    Geological Institute, Slovak Academy of Sciences.
    Ahlberg, Per E.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    A putative upupiform bird from the Early Oligocene of the Central Western Carpathians and a review of fossil birds unearthed in Slovakia2015Ingår i: Acta Zoologica (Stockholm), ISSN 0001-7272, E-ISSN 1463-6395, Vol. 96, nr 1, s. 45-59Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    An isolated hind limb of a miniature bird from an Early Oligocene locality (30–34 Ma) near Bystre (Slovakia) is described and analyzed. The tarsometatarsus (TMT) of the specimen is remarkably short relative to the tibiotarsus. When relative length ratios of the bones are compared with a sample of 29 extant and extinct birds with short metatarsi, the specimen variably clusters with some alcedinids, coraciids and trochilids. Log-clusters give less ambiguous results and indicate significant proximity of the Bystre specimen to the extinct messelirrisorids (Upupiformes) and the recent alcedinids (Coraciiformes). With regard to morphological details, such as those of the first metatarsal, II-IV metatarsal trochleae, intertrochlear incisurae and phalanges, the Slovak specimen shows a combination of features, which are distributed among recent upupiforms and coraciiforms as well as extinct upupiforms (Messelirrisor) and apodiforms (Eocypselus, Parargornis). Taken together, the metric and morphological data sets suggest that the specimen from Bystre is a coraciiform sensu lato rather than an apodiform bird. Within the Coraciiformes, the robust trochlea of MT-I with expanded dorsal shelf, the large medial and slit-like lateral intertrochlear incisura, and the long hindtoe suggest upupiform rather than alcedinid relationships.

  • 162.
    Kuratani, Shigeru
    et al.
    RIKEN, Lab Evolutionary Morphol, Chuo Ku, 2-2-3 Minatojima Minami, Kobe, Hyogo 6500047, Japan..
    Ahlberg, Per E.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Evolution of the vertebrate neurocranium: problems of the premandibular domain and the origin of the trabecula2018Ingår i: ZOOLOGICAL LETTERS, ISSN 2056-306X, Vol. 4, artikel-id 1Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    The subdivision of the gnathostome neurocranium into an anterior neural crest-derived moiety and a posterior mesodermal moiety has attracted the interest of researchers for nearly two centuries. We present a synthetic scenario for the evolution of this structure, uniting developmental data from living cyclostomes and gnathostomes with morphological data from fossil stem gnathostomes in a common phylogenetic framework. Ancestrally, vertebrates had an anteroposteriorly short forebrain, and the neurocranium was essentially mesodermal; skeletal structures derived from premandibular ectomesenchyme were mostly anterior to the brain and formed part of the visceral arch skeleton. The evolution of a one-piece neurocranial 'head shield' in jawless stem gnathostomes, such as galeaspids and osteostracans, caused this mesenchyme to become incorporated into the neurocranium, but its position relative to the brain and nasohypophyseal duct remained unchanged. Basically similar distribution of the premandibular ectomesenchyme is inferred, even in placoderms, the earliest jawed vertebrates, in which the separation of hypophyseal and nasal placodes obliterated the nasohypophyseal duct, leading to redeployment of this ectomesenchyme between the separate placodes and permitting differentiation of the crown gnathostome trabecula that floored the forebrain. Initially this region was very short, and the bulk of the premandibular cranial part projected anteroventral to the nasal capsule, as in jawless stem gnathostomes. Due to the lengthening of the forebrain, the anteriorly projecting 'upper lip' was lost, resulting in the modern gnathostome neurocranium with a long forebrain cavity floored by the trabeculae.

  • 163.
    Lebedev, O. A.
    et al.
    Russian Acad Sci, Borissiak Paleontol Inst, Moscow 117997, Russia..
    Sennikov, A. G.
    Russian Acad Sci, Borissiak Paleontol Inst, Moscow 117997, Russia.;Kazan Fed Univ, Kazan 420008, Russia..
    Golubev, V. K.
    Russian Acad Sci, Borissiak Paleontol Inst, Moscow 117997, Russia.;Kazan Fed Univ, Kazan 420008, Russia..
    Krupina, N. I.
    Moscow MV Lomonosov State Univ, Earth Sci Museum, Moscow 119991, Russia..
    Niedzwiedzki, Grzegorz
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Sulej, T.
    Polish Acad Sci, Inst Paleobiol, PL-00818 Warsaw, Poland..
    The first find of Permian ceratodontids (Dipnoi, Osteichthyes) in Russia2015Ingår i: Paleontological journal, ISSN 0031-0301, E-ISSN 1555-6174, Vol. 49, nr 10, s. 1112-1124Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A huge dipnoan, Permoceratodus gentilis Krupina, gen. et sp. nov. (order Ceratodontiformes), from the terminal Permian beds (Zhukovian Regional Stage, Vyatkian Stage, Upper Permian) of the Sokovka locality (Vladimir Region) is described. It is characterized by the evolutionarily advanced high extent of fusion of skull roof bones and conservative well defined structures of the seismosensory system of the head. This combination distinguishes the new taxon from other Ceratodontiformes. A set of conservative and advanced characters is observed in many vertebrates of the Vyazniki faunal assemblage. Large tetrapods and fishes characterize the terminal developmental stage of the Permian fauna of Eastern Europe, which was followed by impoverishment of the taxonomic composition accompanied by a decrease in body size. The dipnoan described here, like some other vertebrates of this assemblage, belong to high-rank taxa, which had just appeared in the Paleozoic, but reached flourishing in the Mesozoic.

  • 164.
    Lindgren, Johan
    et al.
    Lund Univ, Dept Geol, Lund, Sweden.
    Sjövall, Peter
    RISE Res Inst Sweden Chem & Mat, Boras, Sweden.
    Thiel, Volker
    Univ Gottingen, Geosci Ctr, Geobiol, Gottingen, Germany.
    Zheng, Wenxia
    North Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA.
    Ito, Shosuke
    Fujita Hlth Univ, Sch Hlth Sci, Dept Chem, Toyoake, Aichi, Japan.
    Wakamatsu, Kazumasa
    Fujita Hlth Univ, Sch Hlth Sci, Dept Chem, Toyoake, Aichi, Japan.
    Hauff, Rolf
    Urweltmuseum Hauff, Holzmaden, Germany.
    Kear, Benjamin P.
    Uppsala universitet, Enheten för musik och museer, Evolutionsmuseet.
    Engdahl, Anders
    Lund Univ, MAX Lab 4, Lund, Sweden.
    Alwmark, Carl
    Lund Univ, Dept Geol, Lund, Sweden.
    Eriksson, Mats E.
    Lund Univ, Dept Geol, Lund, Sweden.
    Jarenmark, Martin
    Lund Univ, Dept Geol, Lund, Sweden.
    Sachs, Sven
    Nat Kunde Museum Bielefeld, Abt Geowissensch, Bielefeld, Germany.
    Ahlberg, Per
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Marone, Federica
    Paul Scherrer Inst, Swiss Light Source, Villigen, Switzerland.
    Kuriyama, Takeo
    Univ Hyogo, Inst Nat & Environm Sci, Kobe, Hyogo, Japan;Wildlife Management Res Ctr, Tanba, Hyogo, Japan.
    Gustafsson, Ola
    Lund Univ, Dept Biol, Lund, Sweden.
    Malmberg, Per
    Chalmers Univ Technol, Dept Chem & Chem Engn, Gothenburg, Sweden.
    Thomen, Aurelien
    Univ Gothenburg, Dept Chem & Mol Biol, Gothenburg, Sweden.
    Rodriguez-Meizoso, Irene
    Lund Univ, Dept Chem, Ctr Anal & Synth, Lund, Sweden.
    Uvdal, Per
    Lund Univ, Dept Chem, Chem Phys, Lund, Sweden.
    Ojika, Makoto
    Nagoya Univ, Grad Sch Bioagr Sci, Dept Appl Biosci, Nagoya, Aichi, Japan.
    Schweitzer, Mary H.
    Lund Univ, Dept Geol, Lund, Sweden;North Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA;North Carolina Museum Nat Sci, Raleigh, NC USA.
    Soft-tissue evidence for homeothermy and crypsis in a Jurassic ichthyosaur2018Ingår i: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 564, nr 7736, s. 359-365Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Ichthyosaurs are extinct marine reptiles that display a notable external similarity to modern toothed whales. Here we show that this resemblance is more than skin deep. We apply a multidisciplinary experimental approach to characterize the cellular and molecular composition of integumental tissues in an exceptionally preserved specimen of the Early Jurassic ichthyosaur Stenopterygius. Our analyses recovered still-flexible remnants of the original scaleless skin, which comprises morphologically distinct epidermal and dermal layers. These are underlain by insulating blubber that would have augmented streamlining, buoyancy and homeothermy. Additionally, we identify endogenous proteinaceous and lipid constituents, together with keratinocytes and branched melanophores that contain eumelanin pigment. Distributional variation of melanophores across the body suggests countershading, possibly enhanced by physiological adjustments of colour to enable photoprotection, concealment and/or thermoregulation. Convergence of ichthyosaurs with extant marine amniotes thus extends to the ultrastructural and molecular levels, reflecting the omnipresent constraints of their shared adaptation to pelagic life.

  • 165.
    Lisney, Thomas J.
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Ekesten, Björn
    Tauson, Ragnar
    Håstad, Olle
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Ödeen, Anders
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Using electroretinograms to assess flicker fusion frequency in domestic hens Gallus gallus domesticus2012Ingår i: Vision Research, ISSN 0042-6989, E-ISSN 1878-5646, Vol. 62, s. 125-133Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The assessment of flicker fusion frequency (FFF), the stimulus frequency at which a flickering light stimulus can no longer be resolved and appears continuous, and critical flicker fusion frequency (CFF; the highest frequency at any light intensity that an observer can resolve flicker) are useful methods for comparing temporal resolution capabilities between animals. Behavioural experiments have found that average CFFs in domestic chickens (Gallus gallus domesticus) are in the range of ca. 75-87 Hz, measured in response to full spectrum (i.e. white light plus UV) stimuli. In order to examine whether the chicken retina is able to detect flicker at higher frequencies, we used electroretinograms (ERGs) to assess FFF/CFF in adult hens from two commercial genotypes, Lohmann Selected Leghorns (LSLs) and Lohmann Browns (LBs). ERGs were recorded in response to flickering light at ten full spectrum light intensities ranging from 0.7 to 2740 cd m(-2). Two methods were used to determine FFF/CFF from the ERG recordings and these methods yielded very similar results, with average FFF ranging from ca. 20 Hz at 0.7 cd m(-2) to an average CFF of ca. 105 Hz at 2740 cd m(-2). In some individuals, CFFs of 118-119 Hz were recorded. The Intensity/FFF (I/FFF) curves are double-branched with a break point representing the rod-cone transition occurring between 2.5 and 5.9 cd m(-2). No significant differences in the I/FFF curves were found between the two genotypes. At stimulus light intensities >250 cd m(-2), the ERG-derived FFF and CFF values are all higher than those from behavioural studies using the same stimuli. Although hens do not appear to be able to consciously perceive flicker above approximately 90 Hz, the finding that the ERG responses are able to remain in phase with light flickering at frequencies >100 Hz means that the retinae of domestic poultry housed in artificial light conditions may be able to resolve flicker from fluorescent lamps. As range of detrimental effects have been reported in humans as a result of exposure to such "invisible flicker", the possibility exists that flicker from fluorescent lamps also acts as stressor in domesticated birds.

  • 166.
    Lisney, Thomas J.
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Rubene, Diana
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Rozsa, Jani
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Løvlie, Hanne
    Håstad, Olle
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Ödeen, Anders
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Behavioural assessment of flicker fusion frequency in chicken Gallus gallus domesticus2011Ingår i: Vision Research, ISSN 0042-6989, E-ISSN 1878-5646, Vol. 51, nr 12, s. 1324-1332Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    To interact with its visual environment, an organism needs to perceive objects in both space and time. High temporal resolution is hence important to the fitness of diurnally active animals, not least highly active aerial species such as birds. However, temporal resolution, as assessed by flicker fusion frequency (FFF; the stimulus frequency at which a flickering light stimulus can no longer be resolved and appears continuous) or critical flicker fusion frequency (CFF; the highest flicker fusion frequency at any light intensity) has rarely been assessed in birds. In order to further our understanding of temporal resolution as a function of light intensity in birds we used behavioural experiments with domestic chickens (Gallus gallus domesticus) from an old game breed 'Gammalsvensk dvarghona' (which is morphologically and behaviourally similar to the wildtype ancestor, the red jungle fowl, G. gallus), to generate an 'Intensity/FFF curve' (I/FFF curve) across full spectrum light intensities ranging from 0.2 to 2812 cd m(-2). The I/FFF curve is double-branched, resembling that of other chordates with a duplex retina of both rods and cones. Assuming that the branches represent rod and cone mediated responses respectively, the break point between them places the transition between scotopic and photopic vision at between 0.8 and 1.9 cd m(-2). Average FFF ranged from 19.8 Hz at the lowest light intensity to a CFF 87.0 Hz at 1375 cd m(-2). FFF dropped slightly at the highest light intensity. There was some individual variation with certain birds displaying CFFs of 90-100 Hz. The FFF values demonstrated by this non-selected breed appear to be considerably higher than other behaviourally derived FFF values for similar stimuli reported for white and brown commercial laying hens, indicating that the domestication process might have influenced temporal resolution in chicken.

  • 167.
    Long, John A.
    et al.
    Flinders University, Adelaide, South Australia.
    Mark-Kurik, Elga
    Tallinn University of Technology.
    Johanson, Zerina
    The Natural History Museum, London.
    Lee, Michael S.Y.
    South Australian Museum, Adelaide.
    Young, Gavin C.
    Australian National University, Canberra.
    Zhu, Min
    Institute of Vertebrate Palaeontology and Palaeoanthropology, Chinese Academy of Sciences, Beijing.
    Ahlberg, Per Erik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Newman, Michael
    Jones, Roger
    den Blaauwen, Jan
    University of Amsterdam.
    Choo, Brian
    Flinders University, Adelaide.
    Trinajstic, Kate
    Curtin University, Perth, Western Australia.
    Copulation in antiarch placoderms and the origin of gnathostome internal fertilization2015Ingår i: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 517, nr 7533, s. 196-199Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Reproduction in jawed vertebrates (gnathostomes) involves either external or internal fertilization. It is commonly argued that internal fertilization can evolve from external, but not the reverse. Male copulatoryclaspers are present in certain placoderms, fossil jawed vertebrates retrieved as a paraphyletic segment of the gnathostome stem group in recent studies. This suggests that internal fertilization could be primitive for gnathostomes, but such a conclusion depends on demonstrating that copulation was not just a specialized feature of certain placoderm subgroups. The reproductive biology of antiarchs, consistently identified as the least crownward placoderms and thus of great interest in this context, has until now remained unknown. Here we show that certain antiarchs possessed dermal claspers in the males, while females bore paired dermal plates inferred to have facilitated copulation. These structures are not associated with pelvic fins. The clasper morphology resembles that of ptyctodonts, a more crownward placoderm group, suggesting that all placoderm claspers are homologous and that internal fertilization characterized all placoderms. This implies that external fertilization and spawning, which characterize most extant aquatic gnathostomes, must be derived from internal fertilization, even though this transformation has been thought implausible. Alternatively, the substantial morphological evidence for placoderm paraphyly must be rejected.

  • 168.
    Looy, Cindy V.
    et al.
    Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Museum Paleontol, Berkeley, CA 94720 USA..
    Ranks, Stephanie L.
    Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Museum Paleontol, Berkeley, CA 94720 USA..
    Chaney, Dan S.
    Smithsonian Inst, NMNH, Dept Paleobiol, Washington, DC 20560 USA..
    Sanchez, Sophie
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Steyer, Jean-Sebastien
    UPMC, Ctr Rech Paleobiodivers & Paleoenvironnements, MNHN, UMR 7207,CNRS, CP 38,8 Rue Buffon, F-75005 Paris, France..
    Smith, Roger M. H.
    Iziko South African Museum, Karoo Palaeontol, ZA-8000 Cape Town, South Africa.;Univ Witwatersrand, Evolutionary Studies Inst, 1 Jan Smuts Ave, ZA-2000 Johannesburg, South Africa..
    Sidor, Christian A.
    Univ Washington, Burke Museum, Seattle, WA 98195 USA.;Univ Washington, Dept Biol, Seattle, WA 98195 USA..
    Myers, Timothy S.
    So Methodist Univ, Huffington Dept Earth Sci, Dallas, TX 75275 USA..
    Ide, Oumarou
    Inst Rech Sci Humaines, Niamey, Niger..
    Tabor, Neil J.
    So Methodist Univ, Huffington Dept Earth Sci, Dallas, TX 75275 USA..
    Biological and physical evidence for extreme seasonality in central Permian Pangea2016Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology, ISSN 0031-0182, E-ISSN 1872-616X, Vol. 451, s. 210-226Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Climate models indicate increased desertification in the continental interior of Pangea during the Permian, which would have affected the composition of the flora and fauna. We present a multi-proxy paleoenvironmental reconstruction of a terrestrial ecosystem in central Pangea of Lopingian age. The reconstruction is based on biological and physical data from the Moradi Formation, located in the Tim Mersoi sub-Basin, northern Niger. Paleosols and sedimentological evidence indicate that the prevailing climate was semi-arid to very arid with marked intervals of high water availability. Carbon stable isotope data from organic matter and paleosols suggest that both the soil productivity and actual evapotranspiration were very low, corresponding to arid conditions. Histological analysis of pareiasaur bones shows evidence of active metabolism and reveals distinct growth marks. These interruptions of bone formation are indicative of growth rhythms, and are considered as markers for contrasting seasonality orepisodic climate events. The macrofossil floras have low diversity and represent gymnosperm dominated woodlands. Most notable are ovuliferous dwarf shoots of voltzian conifers, and a 25-m long tree trunk with irregularly positioned branch scars. The combined biological and physical evidence suggests that the Moradi Formation was deposited under a generally arid climate with recurring periods of water abundance, allowing for a well-established ground water-dependent ecosystem. With respect to its environment, this system is comparable with modern ecosystems such as the southern African Namib Desert and the Lake Eyre Basin in Australia, which are discussed as modern analogues.

  • 169.
    Loskog, Angelica
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Maleka, Aglaia
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Mangsbo, Sara
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Svensson, Emma
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Lundberg, Christina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.
    Nilsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.
    Krause, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.
    Agnarsdóttir, Margrét
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Sundin, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.
    Ahlström, Håkan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.
    Tötterman, Thomas H
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Ullenhag, Gustav
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients2016Ingår i: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 114, nr 8, s. 872-880Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Current approaches for treating metastatic malignant melanoma (MM) are not effective enough and are associated with serious adverse events. Due to its immunogenicity, melanoma is an attractive target for immunostimulating therapy. In this phase I/IIa study, local AdCD40L immunostimulatory gene therapy was evaluated in patients with MM.

    METHODS: AdCD40L is an adenovirus carrying the gene for CD40 ligand. Patients that failed standard treatments were enrolled. Six patients received four weekly intratumoral AdCD40L injections. Next, nine patients received low-dose cyclophosphamide conditioning before the first and fourth AdCD40L injection. The blood samples were collected at multiple time points for chemistry, haematology and immunology evaluations. Radiology was performed at enrolment and repeated twice after the treatment.

    RESULTS: AdCD40L was safe with mild transient reactions. No objective responses were recorded by MRI, however, local and distant responses were seen on FDG-PET. The overall survival at 6 months was significantly better when cyclophosphamide was added to AdCD40L. The patients with the best survival developed the highest levels of activated T cells and experienced a pronounced decrease of intratumoral IL8.

    CONCLUSIONS: AdCD40L therapy for MM was well tolerated. Local and distant responses along with better survival in the low-dose cyclophosphamide group are encouraging.

  • 170.
    Lu, Jing
    et al.
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China..
    Zhu, Min
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China..
    Ahlberg, Per Erik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Qiao, Tuo
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China..
    Zhu, You-an
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China.
    Zhao, Wenjin
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China..
    Jia, Liantao
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China..
    A Devonian predatory fish provides insights into the early evolution of modern sarcopterygians2016Ingår i: SCIENCE ADVANCES, ISSN 2375-2548, Vol. 2, nr 6, artikel-id e1600154Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Crown or modern sarcopterygians (coelacanths, lungfishes, and tetrapods) differ substantially from stem sarcopterygians, such as Guiyu and Psarolepis, and a lack of transitional fossil taxa limits our understanding of the origin of the crown group. The Onychodontiformes, an enigmatic Devonian predatory fish group, seems to have characteristics of both stem and crown sarcopterygians but is difficult to place because of insufficient anatomical information. We describe the new skull material of Qingmenodus, a Pragian (similar to 409-million-year-old) onychodont from China, using high-resolution computed tomography to image internal structures of the braincase. In addition to its remarkable similarities with stem sarcopterygians in the ethmosphenoid portion, Qingmenodus exhibits coelacanth-like neurocranial features in the otic region. A phylogenetic analysis based on a revised data set unambiguously assigns onychodonts to crown sarcopterygians as stem coelacanths. Qingmenodus thus bridges the morphological gap between stem sarcopterygians and coelacanths and helps to illuminate the early evolution and diversification of crown sarcopterygians.

  • 171. Lu, Junchang
    et al.
    Pu, Hanyong
    Kobayashi, Yoshitsugu
    Xu, Li
    Chang, Huali
    Shang, Yuhua
    Liu, Di
    Lee, Yuong-Nam
    Kundrat, Martin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Shen, Caizhi
    A New Oviraptorid Dinosaur (Dinosauria: Oviraptorosauria) from the Late Cretaceous of Southern China and Its Paleobiogeographical Implications2015Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, artikel-id 11490Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The Ganzhou area of Jiangxi Province, southern China is becoming one of the most productive oviraptorosaurian localities in the world. A new oviraptorid dinosaur was unearthed from the uppermost Upper Cretaceous Nanxiong Formation of Ganzhou area. It is characterized by an anterodorsally sloping occiput and quadrate (a feature shared with Citipati), a circular supratemporal fenestra that is much smaller than the lower temporal fenestra, and a dentary in which the dorsal margin above the external mandibular fenestra is strongly concave ventrally. The position of the anteroventral corner of the external naris in relation to the posterodorsal corner of the antorbital fenestra provides new insight into the craniofacial evolution of oviraptorosaurid dinosaurs. A phylogenetic analysis recovers the new taxon as closely related to the Mongolian Citipati. Six oviraptorid dinosaurs from the Nanxiong Formation (Ganzhou and Nanxiong) are distributed within three clades of the family. Each of the three clades from the Nanxiong Formation has close relatives in Inner Mongolia and Mongolia, and in both places each clade may have had a specific diet or occupied a different ecological niche. Oviraptorid dinosaurs were geographically widespread across Asia in the latest Cretaceous and were an important component of terrestrial ecosystems during this time.

  • 172. Lu, Junchang
    et al.
    Pu, Hanyong
    Xu, Li
    Wei, Xuefang
    Chang, Huali
    Kundrat, Martin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    A new rhamphorhynchid pterosaur (Pterosauria) from Jurassic deposits of Liaoning Province, China2015Ingår i: Zootaxa, ISSN 1175-5326, E-ISSN 1175-5334, Vol. 3911, nr 1, s. 119-129Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Compared to pterosaurs from the Early Cretaceous from China, Late Jurassic pterosaurs are relatively rare. A new rhamphorhynchid pterosaur, Orientognathus chaoyngensis gen. et sp. nov., is erected based on an incomplete skeleton from the Upper Jurassic Tuchengzi Formation of Chaoyang, Liaoning Province, China. It is identified by the following characters: the toothless tip of the lower jaw is slightly pointed; the length ratio of wing metacarpal to humerus is 0.38, the ulna is shorter than each wing phalanx and the tibia is nearly equal to femur in length. A phylogenetic analysis recovers Orientognathus chaoyngensis as a rhamphorhynchid pterosaur. Orientognathus chaoyngensis is perhaps the youngest Jurassic pterosaur from western Liaoning Province of China.

  • 173. Luksevics, Ervins
    et al.
    Ahlberg, Per E.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Stinkulis, Girts
    Vasilkova, Jelena
    Zupins, Ivars
    Frasnian vertebrate taphonomy and sedimentology of macrofossil concentrations from the Langsede Cliff, Latvia2012Ingår i: Lethaia: an international journal of palaeontology and stratigraphy, ISSN 0024-1164, E-ISSN 1502-3931, Vol. 45, nr 3, s. 356-370Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The siliciclastic sequence of the Upper Devonian of Kurzeme, Western Latvia, is renowned for abundant vertebrate fossils, including the stem tetrapods Obruchevichthys gracilis and Ventastega curonica. During the first detailed taphonomic study of the vertebrate assemblage from the Ogre Formation cropping out at the Langsede Cliff, Imula River, abundant vertebrate remains have been examined and identified as belonging to one psammosteid, two acanthodian and three sarcopterygian genera; the placoderm Bothriolepis maxima dominates the assemblage. Besides fully disarticulated placoderm and psammosteid plates, separate sarcopterygian scales and teeth, and acanthodian spines, partly articulated specimens including complete distal segments of Bothriolepis pectoral fins, Bothriolepis head shields and sarcopterygian lower jaws have been found. The size distribution of the placoderm bones demonstrates that the individuals within the assemblage are of approximately uniform age. Distinct zones have been traced within the horizontal distribution of the bones. These linear zones are almost perpendicular to the dominant dip azimuth of the cross-beds and ripple-laminae and most probably correspond to the depressions between subaqueous dunes. Concavity ratio varies significantly within the excavation area. The degree of fragmentation of the bones and disarticulation of the skeletons suggest that the carcasses were reworked and slightly transported before burial. Sedimentological data suggest deposition in a shallow marine environment under the influence of rapid currents. The fossiliferous bed consists of a basal bone conglomerate covered by a cross-stratified sandstone with mud drapes, which is in turn overlain by ripple laminated sandstone, indicating the bones were buried by the gradual infilling of a tidal channel. All the MiddleUpper Devonian vertebrate bone-beds from Latvia are associated with sandy to clayey deposits and have been formed in a sea-coastal zone during rapid sedimentation episodes, but differ in fossil abundance and degree of preservation. 

  • 174.
    Lundgren, Mette
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi.
    Blom, Henning
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Phylogenetic patterns in the heterostracan families Cyathaspidae, Ariaspidae and Ctenaspidae2011Ingår i: Abstracts: The 2nd Wiman meeting : Carl Wiman's Legacy: 100 years of Swedish Palaeontology : Uppsala 17–18 November 2011 / [ed] Benjamin P. Kear and Michael Streng, 2011, s. 16-17Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    The order Heterostraci includes early armoured vertebrates that are defined by a pair of common external branchial openings on either side of the head. The position of these openings and their arrangement in relation to the plates of the dermal armour has been shown to vary in different species of the Cyathaspidae, Ariaspidae and Ctenaspidae (previously grouped in the family Cyathaspididae). In order to explore evolutionary patterns in the branchial region of heterostracans, a phylogenetic analysis comprising 55 skeletal characters and 37 species-level taxa belonging to the Cyathaspidae, Ariaspidae and Ctenaspidae was carried out; this is the first cladistic appraisal of these heterostracan families. The resulting trees place Asketaspis interstincta in a basal position with all other taxa forming a discrete monophyletic clade. This infers aprogressional shift of the branchial opening and rearrangement of the adjacent dermal plates in Alainaspis, Allocryptaspis, and culminating in Ctenaspidae where the branchial opening is relocated to the posterolatertal corner of the dorsal shield and coincides with the loss of the superficial layer of the dermal armour.

  • 175.
    Lundgren, Mette
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Blom, Henning
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Phylogenetic relationships of the cyathaspidids (Heterostraci)2013Ingår i: GFF, ISSN 1103-5897, E-ISSN 2000-0863, Vol. 135, nr 1, s. 74-84Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The present analysis investigates for the first time the phylogenetic relationships of the cyathaspidid heterostracans by the principle of global parsimony on the basis of 36 species and 1 outgroup taxon. In this study, which assumes cyathaspidid monophyly, states for 61 characters were compiled and analysed using maximum parsimony methods, resulting in nine shortest trees of 122 steps each. The strict consensus tree shows a high degree of homoplasy and challenges previous classification schemes. The consensus topology supports previous arguments that the tolypelepids with their characteristic scale-like ornament occupy a basal position among the cyathaspidids.

  • 176.
    Makady, Amr
    et al.
    Zorginst Nederland, Eekholt 4, NL-1112 XH Diemen, Netherlands;Univ Utrecht, Dept Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands.
    Kalf, Rachel R. J.
    Zorginst Nederland, Eekholt 4, NL-1112 XH Diemen, Netherlands.
    Ryll, Bettina
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Melanoma Patient Network Europe, Uppsala, Sweden.
    Spurrier, Gilliosa
    Melanoma Patient Network Europe, Uppsala, Sweden.
    de Boer, Anthonius
    Univ Utrecht, Dept Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands.
    Hillege, Hans
    Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
    Klungel, Olaf H.
    Univ Utrecht, Dept Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands.
    Goettsch, Wim
    Zorginst Nederland, Eekholt 4, NL-1112 XH Diemen, Netherlands;Univ Utrecht, Dept Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands.
    Social media as a tool for assessing patient perspectives on quality of life in metastatic melanoma: a feasibility study2018Ingår i: Health and Quality of Life Outcomes, ISSN 1477-7525, E-ISSN 1477-7525, Vol. 16, artikel-id 222Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: Development of innovative drugs for melanoma is occurring rapidly. Incremental gains in overall survival amongst innovative products may be difficult to measure in clinical trials, and their use may be associated with increased toxicity profiles. Therefore, HTA agencies increasingly require information on HRQoL for the assessment of such drugs. This study explored the feasibility of social media to assess patient perspectives on HRQoL in melanoma, and whether current cancer- and melanoma-specific HRQoL questionnaires represent these perspectives.

    Methods: A survey was distributed on the social media channels of Melanoma Patient Network Europe to assess melanoma patients' perspectives regarding HRQoL. Two researchers independently conducted content analysis to identify key themes, which were subsequently compared to questions from one current cancer-specific and two melanoma-specific HRQoL questionnaires (i.e. EORTC QLQ-C30, EORTC QLQ-MEL38, FACT-M).

    Results: In total, 72 patients and 17 carers completed the survey. Patients indicated that family, having a normal life, and enjoying life were the three most important aspects of HRQoL for them. Carers indicated that being capable, having manageable adverse events, and being pain-free were the three most important aspects of HRQoL for patients. Respondents seem to find some questions from HRQoL questionnaires relevant (e.g. Have you felt able to carry on with things as normal?') and others less relevant (e.g. Have you had swelling near your melanoma site?'). Additionally, wording may differ between patients and HRQoL questionnaires, whereby patients generally use a more positive tone.

    Conclusions: Social media may provide a valuable tool in assessing patient perspectives regarding HRQoL. However, differences seem to emerge between patient and carer perspectives. Additionally, patient perspectives did not seem to fully correlate to questions posed in cancer- (i.e. EORTC QLQ-C30) and melanoma-specific (i.e. EORTC QLQ-MEL38, FACT-M) HRQoL questionnaires examined.

  • 177.
    Makady, Amr
    et al.
    Zorginst Nederland, Diemen, Netherlands;Univ Utrecht, Utrecht, Netherlands.
    Kalf, Rachel
    Zorginst Nederland, Diemen, Netherlands;Univ Utrecht, Utrecht, Netherlands.
    Ryll, Bettina
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Melanoma Patient Network Europe, Brussels, Belgium.
    Spurrier, Gilliosa
    Melanoma Patient Network Europe, Brussels, Belgium.
    de Boer, Anthonius
    Univ Utrecht, Utrecht, Netherlands.
    Hillege, Hans
    Univ Med Ctr Groningen, Groningen, Netherlands.
    Klungel, Olaf
    Univ Utrecht, Utrecht, Netherlands.
    Goettsch, Wim
    Zorginst Nederland, Diemen, Netherlands;Univ Utrecht, Utrecht, Netherlands.
    Using social media to collect patient perspectives on quality of life: A feasibility study2018Ingår i: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 27, nr Suppl. 2, s. 56-56, artikel-id 117Artikel i tidskrift (Övrigt vetenskapligt)
  • 178.
    Makady, Amr
    et al.
    Natl Healthcare Inst ZIN, Diemen, Netherlands.;Univ Utrecht, Dept Pharmacoepidemiol & Clin Pharmacotherapy, Utrecht, Netherlands..
    Stegenga, Heather
    Natl Inst Hlth & Care Excellence NICE, London, England..
    Ciaglia, Antonio
    Int Alliance Patients Org, London, England..
    Debray, Thomas P. A.
    Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Cochrane Netherlands, Utrecht, Netherlands..
    Lees, Michael
    Bristol Myers Squibb, Paris, France..
    Happich, Michael
    Eli Lilly, Hamburg, Germany..
    Ryll, Bettina
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Melanoma Patient Network Europe, Uppsala, Sweden.
    Abrams, Keith
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Thwaites, Rob
    Takeda, London, England..
    Garner, Sarah
    Natl Inst Hlth & Care Excellence NICE, London, England..
    Jonsson, Pall
    Natl Inst Hlth & Care Excellence NICE, London, England..
    Goettsch, Wim
    Natl Healthcare Inst ZIN, Diemen, Netherlands.;Univ Utrecht, Dept Pharmacoepidemiol & Clin Pharmacotherapy, Utrecht, Netherlands..
    Practical implications of using real-world evidence (RWE) in comparative effectiveness research: learnings from IMI-GetReal2017Ingår i: Journal of Comparative Effectiveness Research, ISSN 2042-6305, E-ISSN 2042-6313, Vol. 6, nr 6, s. 485-490Artikel i tidskrift (Övrigt vetenskapligt)
  • 179. Marshall, John
    et al.
    Blom, Henning
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Olive, Sebastien
    Finney, Sarah
    Did ‘Devonian’ fish become extinct at the D-C boundary2015Ingår i: 2nd International Congress on Stratigraphy, STRATI 2015,19. - 23. July 2015, Graz, Austria: Abstracts / [ed] Elisabeth Gülli, Werner E. Piller, 2015, Vol. 21, s. 239-239Konferensbidrag (Refereegranskat)
  • 180. Martinez-Perez, Carlos
    et al.
    Dupret, Vincent
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Manzanares, Esther
    Botella, Hector
    New data on the lower devonian chondrichthyan fauna from celtiberia (Spain)2010Ingår i: Journal of Vertebrate Paleontology, ISSN 0272-4634, E-ISSN 1937-2809, Vol. 30, nr 5, s. 1622-1627Artikel i tidskrift (Refereegranskat)
  • 181.
    Mergl, Michal
    et al.
    Uniersity of West Bohemia.
    Vaskaninova, Valeria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Zigaite, Zivile
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Vertebrate Microremains From The Pragian, Emsian And Eifelian Of The Prague Basin (Czech Republic)2017Ingår i: Folia Musei rerum naturalium Bohemiae occidentalis. Geologica et Paleobiologica, E-ISSN 1805-286X, Vol. 51, nr 1/2, s. 1-12Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The vertebrate faunas in limestone samples of the Early and Middle Devonian ages (Pragian, early Emsian, late Emsian, and latest Eifelian) which were collected from five localities in the Barrandian area, Bohemia, include scales, tesserae, bones, and teeth of acanthodians, placoderms, chondrichthyans, and sarcopterygians. Although the vertebrate remains are not abundant the assemblages are significant in being dominated by particular taxa. Apart from undetermined microremains the genera Cheiracanthoides, Laliacanthus, Nostolepis, and Tassiliodus were determined.

  • 182. Meunier, Dominique
    et al.
    Patra, Kalicharan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Smits, Ron
    Haegebarth, Andrea
    Luettges, Angela
    Jaussi, Rolf
    Wieduwilt, Matthew J.
    Quintanilla-Fend, Leticia
    Himmelbauer, Heinz
    Fodde, Riccardo
    Fundele, Reinald H.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Expression Analysis of Proline Rich 15 (Prr15) in Mouse and Human Gastrointestinal Tumors2011Ingår i: Molecular Carcinogenesis, ISSN 0899-1987, E-ISSN 1098-2744, Vol. 50, nr 1, s. 8-15Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Proline rich 15 (Prr15), which encodes a protein of unknown function, is expressed almost exclusively in postmitotic cells both during fetal development and in adult tissues, such as the intestinal epithelium and the testis. To determine if this specific expression is lost in intestinal neoplasias, we examined Prr15 expression by in situ hybridization (ISH) on mouse intestinal tumors caused by different gene mutations, and on human colorectal cancer (CRC) samples. Prr15/PRR15 expression was consistently observed in mouse gastrointestinal (GI) tumors caused by mutations in the Apc gene, as well as in several advanced stage human CRCs. In contrast, no Prr15 expression was detected in intestinal tumors derived from mice carrying mutations in the Smad3, Smad4, or Cdkn1b genes. These findings, combined with the fact that a majority of sporadic human CRCs carry APC mutations, strongly suggest that the expression of Prr15/PRR15 in mouse and human GI tumors is linked, directly or indirectly, to the absence of the APC protein or, more generally, to the disruption of the Wnt signaling pathway.

  • 183. Mondejar-Fernandez, Jorge
    et al.
    Clement, Gael
    Sanchez, Sophie
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    New insights into the scales of the Devonian tetrapod Tulerpeton curtum Lebedev, 19842014Ingår i: Journal of Vertebrate Paleontology, ISSN 0272-4634, E-ISSN 1937-2809, Vol. 34, nr 6, s. 1454-1459Artikel i tidskrift (Refereegranskat)
  • 184.
    Murer, Fredrik K.
    et al.
    Norwegian Univ Sci & Technol, Dept Phys, Hgsk Ringen 5, N-7491 Trondheim, Norway.
    Sanchez, Sophie
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab. UPMC, CNRS, Sorbonne Univ, CR2P,MNHN, 57 Rue Cuvier,CP38, F-75005 Paris, France;ESRF, 71 Ave Martyrs, F-38000 Grenoble, France.
    Alvarez-Murga, Michelle
    ESRF, 71 Ave Martyrs, F-38000 Grenoble, France.
    Di Michiel, Marco
    ESRF, 71 Ave Martyrs, F-38000 Grenoble, France.
    Pfeiffer, Franz
    Tech Univ Munich, Lehrstuhl Biomed Phys, Dept Phys, D-85748 Garching, Germany;Tech Univ Munich, Inst Med Tech, D-85748 Garching, Germany;Tech Univ Munich, Klinikum Rechts Isar, Dept Diagnost & Intervent Radiol, D-81675 Munich, Germany.
    Bech, Martin
    Lund Univ, Dept Med Radiat Phys, Clin Sci, S-22185 Lund, Sweden.
    Breiby, Dag W.
    Univ South Eastern Norway, Dept Microsyst, N-3184 Borre, Norway;Norwegian Univ Sci & Technol, Dept Phys, Hgsk Ringen 5, N-7491 Trondheim, Norway.
    3D Maps of Mineral Composition and Hydroxyapatite Orientation in Fossil Bone Samples Obtained by X-ray Diffraction Computed Tomography2018Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikel-id 10052Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Whether hydroxyapatite (HA) orientation in fossilised bone samples can be non-destructively retrieved and used to determine the arrangement of the bone matrix and the location of muscle attachments (entheses), is a question of high relevance to palaeontology, as it facilitates a detailed understanding of the (micro-)anatomy of extinct species with no damage to the precious fossil specimens. Here, we report studies of two fossil bone samples, specifically the tibia of a 300-million-year-old tetrapod, Discosauriscus austriacus, and the humerus of a 370-million-year-old lobe-finned fish, Eusthenopteron foordi, using XRD-CT - a combination of X-ray diffraction (XRD) and computed tomography (CT). Reconstructed 3D images showing the spatial mineral distributions and the local orientation of HA were obtained. For Discosauriscus austriacus, details of the muscle attachments could be discerned. For Eusthenopteron foordi, the gross details of the preferred orientation of HA were deduced using three tomographic datasets obtained with orthogonally oriented rotation axes. For both samples, the HA in the bone matrix exhibited preferred orientation, with the unit cell c-axis of the HA crystallites tending to be parallel with the bone surface. In summary, we have demonstrated that XRD-CT combined with an intuitive reconstruction procedure is becoming a powerful tool for studying palaeontological samples.

  • 185. Märss, T.
    et al.
    Afanassieva, O.
    Blom, Henning
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Biodiversity of the Silurian osteostracans of the East Baltic2014Ingår i: Earth and environmental science transactions of the Royal Society of Edinburgh, ISSN 1755-6910, E-ISSN 1755-6929, Vol. 105, nr 2, s. 73-148Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    The sculpture and histology of osteostracan head shields and trunk squamations from the Silurian of Estonia are described, illustrated and used for the identification of disarticulated microremains collected from outcrop sections and numerous drill cores in Estonia and Latvia over the last 40 years. The scattered osteostracan material contains thousands of specimens of scales and shield fragments. The sculpture and histology of species of the previously identified eight genera in the region (Tremataspis, Dartmuthia, Saaremaaspis, Oeselaspis, Aestiaspis, Thyestes, Procephalaspis, Witaaspis) are redescribed, together with Ateleaspis, found in Estonia for the first time. The sculpture on the cornua of several taxa is described for the first time. The new taxa Tremataspis perforata sp. nov., Dartmuthia procera sp. nov., Eldaaspis miklii gen. et sp. nov., Tahulaspis ordinata gen. et sp. nov., Tahulaspis praevia gen. et sp. nov., Meelaidaspis gennadii gen. et sp. nov. and Ohesaareaspis ponticulata gen. et sp. nov. are established, based upon sculpture and histological characteristics of the exoskeleton. The supraoral field with denticles of that field are described for the first time in Oeselaspis pustulata, as is the supraoral plate with buccal denticles in Meelaidaspis gennadii gen. et sp. nov. Thin sections of all taxa (except of Witaaspis) have been studied. This work sheds light on East Baltic osteostracan biodiversity from the Maasi Beds of the Jaagarahu Stage, Sheinwoodian, lower Wenlock up to the Ohesaare Stage, upper Pidoli, Silurian.

  • 186.
    Mörs, Thomas
    et al.
    Swedish Museum Nat Hist, Dept Palaeoblol, POB 50007, SE-10405 Stockholm, Sweden.
    Niedzwiedzki, Grzegorz
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Crispini, Laura
    Univ Genoa, Dipartimento Sci Terra Ambiente & Vita, Genoa, Italy.
    Laeufer, Andreas
    Fed Inst Geosci & Nat Resources BGR, Hannover, Germany.
    Bomfleur, Benjamin
    Westfalische Wilhelms Univ Munster, Inst Geol & Palaontol, Palaeobot Res Grp, Munster, Germany.
    First evidence of a tetrapod footprint from the Triassic of northern Victoria Land, Antarctica2019Ingår i: Polar Research, ISSN 0800-0395, E-ISSN 1751-8369, Vol. 38, artikel-id 3438Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Here, we report on a tetrapod footprint from the Transantarctic Basin in the far north of Victoria Land, which marks the first record of terrestrial vertebrates for this region. The single specimen derives from a previously unknown lithological unit of Middle or Late Triassic age of the Beacon Supergroup in the Helliwell Hills in the central Rennick Glacier area. It differs in both size and morphology clearly from Middle Triassic trackway types from the upper Fremouw Formation of the Queen Alexandra Range in southern Victoria Land, and likely represents a primitive amniote, procolophonid or therapsid. The footprint is the third evidence of fossil vertebrate trackways in Antarctica.

  • 187. Narkiewicz, Marek
    et al.
    Grabowski, Jacek
    Narkiewicz, Katarzyna
    Niedzwiedzki, Grzegorz
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Retallack, Gregory J.
    Szrek, Piotr
    De Vleeschouwer, David
    Palaeoenvironments of the Eifelian dolomites with earliest tetrapod trackways (Holy Cross Mountains, Poland)2015Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology, ISSN 0031-0182, E-ISSN 1872-616X, Vol. 420, s. 173-192Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The Eifelian dolomites in the Zachelmie Quarry (Holy Cross Mountains, Poland) contain tracicways and tracks of tetrapods 390-391 Ma old, and thus the oldest known so far. The environments of the trackway-bearing beds have been investigated using sedimentological, palaeontological, geochemical and palaeomagnetic methods. The reconstructed tetrapod habitats comprised shallow-water lagoons separated from an open marine basin by sparsely vegetated islands and spits. The lagoonal waters were well-aerated and a few metres deep at most, undergoing periodic desiccation. The dolomitic sediments, primarily of microbial origin, formed in tropical waters of slightly modified marine composition. Oxygen isotope data obtained from the dolomicrites suggest water temperatures around 30 degrees C. The seasonal semi-arid to sub-humid climate, deduced from paleosol characteristics, was probably of a tropical monsoonal type. The degree of restriction of the lagoonal system evolved from relatively open, evaporation-dominated towards increasingly closed, freshwater influenced. The detailed observations of the footprint-bearing beds, as well as the characteristics of the tracks, indicate that they were formed mostly under subaqueous conditions, by wading, walking on the bottom or swimming animals. Lack of tidal indicators in the restricted Zachelmie lagoons argues against previous concept that tidal flats served as a food source for the early tetrapods. Nor is a hypothesis of flooded woodlands confirmed as a habitat promoting the "fish-to-tetrapod" transition. We propose that functional limbs emerged among aqueous animals that acquired their locomotional capabilities in a shallow lagoonal water before attempting longer excursions on land.

  • 188.
    Nesbitt, Sterling J.
    et al.
    Virginia Tech, Dept Geosci, Blacksburg, VA 24061 USA..
    Butler, Richard J.
    Univ Birmingham, Sch Geog Earth & Environm Sci, Birmingham B15 2TT, W Midlands, England..
    Ezcurra, Martin D.
    Univ Birmingham, Sch Geog Earth & Environm Sci, Birmingham B15 2TT, W Midlands, England.;Museo Argentino Ciencias Nat Bernardino Rivadavia, CONICET, Secc Paleontol Vertebrados, Buenos Aires, DF, Argentina..
    Barrett, Paul M.
    Nat Hist Museum, Dept Earth Sci, Cromwell Rd, London SW7 5BD, England..
    Stocker, Michelle R.
    Virginia Tech, Dept Geosci, Blacksburg, VA 24061 USA..
    Angielczyk, Kenneth D.
    Field Museum Nat Hist, Integrat Res Ctr, 1400 South Lake Shore Dr, Chicago, IL 60605 USA..
    Smith, Roger M. H.
    Univ Witwatersrand, Evolutionary Studies Inst, PO Wits 2050, Johannesburg, South Africa.;Iziko South African Museum, POB 61, Cape Town, South Africa..
    Sidor, Christian A.
    Univ Washington, Burke Museum, Seattle, WA 98195 USA.;Univ Washington, Dept Biol, Seattle, WA 98195 USA..
    Niedzwiedzki, Grzegorz
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Sennikov, Andrey G.
    Russian Acad Sci, Borissiak Paleontol Inst, Profsoyuznaya 123, Moscow 117997, Russia.;Kazan Fed Univ, Kremlyovskaya Ul 18, Kazan 420008, Russia..
    Charig, Alan J.
    Nat Hist Museum, Dept Earth Sci, Cromwell Rd, London SW7 5BD, England..
    The earliest bird-line archosaurs and the assembly of the dinosaur body plan2017Ingår i: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 544, nr 7651, s. 484-+Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The relationship between dinosaurs and other reptiles is well established(1-4), but the sequence of acquisition of dinosaurian features has been obscured by the scarcity of fossils with transitional morphologies. The closest extinct relatives of dinosaurs either have highly derived morphologies(5-7) or are known from poorly preserved(8,9) or incomplete material(10,11). Here we describe one of the stratigraphically lowest and phylogenetically earliest members of the avian stem lineage (Avemetatarsalia), Teleocrater rhadinus gen. et sp. nov., from the Middle Triassic epoch. The anatomy of T. rhadinus provides key information that unites several enigmatic taxa from across Pangaea into a previously unrecognized clade, Aphanosauria. This clade is the sister taxon of Ornithodira (pterosaurs and birds) and shortens the ghost lineage inferred at the base of Avemetatarsalia. We demonstrate that several anatomical features long thought to characterize Dinosauria and dinosauriforms evolved much earlier, soon after the bird-crocodylian split, and that the earliest avemetatarsalians retained the crocodylian-like ankle morphology and hindlimb proportions of stem archosaurs and early pseudosuchians. Early avemetatarsalians were substantially more species-rich, widely geographically distributed and morphologically diverse than previously recognized. Moreover, several early dinosauromorphs that were previously used as models to understand dinosaur origins may represent specialized forms rather than the ancestral avemetatarsalian morphology.

  • 189.
    Niedzwiedzki, Grzegorz
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Carboniferous tetrapod footprints from the Lublin Basin, SE Poland2015Ingår i: GFF, ISSN 1103-5897, E-ISSN 2000-0863, Vol. 137, nr 1, s. 57-65Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Evidence of tetrapod footprints is scarce in the Carboniferous rocks of Europe and only a dozen sites have been found. Here is presented the first description of the Carboniferous tetrapod traces collected from the Bogdanka Coal Mine, Lublin Basin, south-eastern Poland. The footprints occur in reddish, white-gray sandstone or black-brown siltstone-mudstone, fluvial and lacustrine in origin, of the Westphalian A and B (about 315 and 310Ma, lower-middle Pennsylvanian) of the Lublin Formation. Based on the study of 19 specimens (isolated and usually poorly preserved manus or pes imprints), I discern two distinct types of tetrapod footprints and also problematic traces (or scratches) made by swimming tetrapods. Footprints are assigned to the two ichnotaxa: Batrachichnus-Limnopus plexus and aff. Pseudobradypus isp. Traces described as Tetrapoda indet. A-C represent poorly preserved footprints, which are similar to the ichnogenera Ichniotherium, Dimetropus and Attenosaurus. The described trace fossils were produced by small amphibians (temnospondyls) and medium-sized amniotes (reptiliomorphs and reptiles). The tetrapod ichnofauna from the Bogdanka Coal Mine is similar in composition to Pennsylvanian ichnofaunas from Europe and North America.

  • 190.
    Niedzwiedzki, Grzegorz
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Bajdek, Piotr
    Aleja Najswietszej Maryi Panny 20-20A, PL-42200 Czestochowa, Poland..
    Owocki, Krzysztof
    Polish Acad Sci, Inst Paleobiol, Twarda 51-55, PL-00818 Warsaw, Poland..
    Kear, Benjamin P.
    Uppsala universitet, Enheten för musik och museer, Evolutionsmuseet.
    An Early Triassic polar predator ecosystem revealed by vertebrate coprolites from the Bulgo Sandstone (Sydney Basin) of southeastern Australia2016Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology, ISSN 0031-0182, E-ISSN 1872-616X, Vol. 464, s. 5-15Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Vertebrate trace fossils often provide a measure of cryptic biodiversity, and are especially pertinent when skeletal remnants are exceptionally rare. The Lower Triassic (lower Olenekian) Bulgo Sandstone at Long Reef in the Sydney Basin of southeastern Australia constitutes just such a deposit, having yielded isolated bones of giant capitosaurian temnospondyls and proterosuchid archosauriforms, together with abundant coprolites that are geochemically rich in elemental phosphate and carbon denoting vertebrate predators. Microstructural analysis of these preserved droppings reveals occasional bone fragments, fish scales, insect cuticles, plant material and bacterial traces (pseudomorph voids), as well as silicate mineral particles. REE concentrations indicate that burial and early diagenesis occurred explicitly within fluvial sediments. Furthermore, external morphological characterization permits attribution of spiral coprolites to chondrichthyan or osteichthyan fishes, polygonal, ovoid spherical and typically flattened feces to temnospondyls, and conspicuously large cylindrical droppings to archosauriforms or other amniote apex predators. Collectively, the Bulgo Sandstone coprolite assemblage thus offers new insights into ecosystem structure and palaeoenvironment in what was an earliest Triassic near polar setting. Such data compliments the documented skeletal record, but indicates a greater range of aquatic and possibly terrestrial carnivores the latter being enigmatically sparse in the Australian Triassic and yet detected here via the hitherto underexplored trace fossil evidence of their ecological presence.

  • 191.
    Niedzwiedzki, Grzegorz
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Bajdek, Piotr
    Aleja Najswietszej Maryi Panny 20-20A, PL-42200 Czestochowa, Poland..
    Qvarnström, Martin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Sulej, Tomasz
    Polish Acad Sci, Inst Paleobiol, Twarda 51-55, PL-00818 Warsaw, Poland..
    Sennikov, Andrey G.
    Russian Acad Sci, Borissiak Paleontol Inst, Profsoyuznaya 123, Moscow 117997, Russia.;Kazan Fed Univ, Kremlyovskaya 18, Kazan 420008, Russia..
    Golubev, Valeriy K.
    Russian Acad Sci, Borissiak Paleontol Inst, Profsoyuznaya 123, Moscow 117997, Russia.;Kazan Fed Univ, Kremlyovskaya 18, Kazan 420008, Russia..
    Reduction of vertebrate coprolite diversity associated with the end-Permian extinction event in Vyazniki region, European Russia2016Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology, ISSN 0031-0182, E-ISSN 1872-616X, Vol. 450, s. 77-90Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This study investigates the paleoecological significance of vertebrate coprolites collected from seven sections and three lithofacies of the uppermost Permian and lowermost Triassic succession from the Vyazniki site in the European part of Russia. The analyzed specimens (coprolites and possibly some cololites) were grouped into nine morphotypes (A-I). The coprolite morphotypes were characterized geochemically and compared to the record of other Permian and Triassic coprolites worldwide. Based on the stratigraphic position, shape, structure and composition, all morphotypes were linked to supposed producers. The phosphatic composition of most of the morphotypes and inclusions of arthropod remains, fish scales and bone fragments, suggest that they were produced by carnivores, but non-phosphatic, carbonate-rich, large and oval-shaped coprolites with impressions after plant remains have also been found. The extinction of terrestrial vertebrates around the Permian-Triassic boundary in Russia is interpreted to have occurred within a few thousands of years. Here, we show a pattern of coprolite morphotypes disappearing across this boundary that is consistent with a relatively sudden change in the vertebrate faunal composition across this interval.

  • 192.
    Niedzwiedzki, Grzegorz
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Bojanowski, Maciej