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  • 15551.
    Asztalos Morell, Ildikó
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Uppsala Centre for Russian and Eurasian Studies. Mälardalen university.
    Voicing Roma Women: Intersectional Marginalities and social entrepreneurship of a Roma women's NGO in Hungary2015In: Institutionalizing Gender Equality: Historical and Global Perspectives / [ed] Yulia Gradskova & Sara Sanders, Lanham: Lexington Books, 2015, Vol. 8, no 3-4, p. 149-173Chapter in book (Refereed)
    Abstract [en]

    The paper explores how the complexity of Roma women’s status is addressed in Szines Gyöngyök (SZGY) a Roma women’s NGO in Hungary:

    Firstly, by analysing the ways in which Roma women’s multiple marginalities are constructed within their own communities and the broader society as well as in the public and private spheres. This approach highlights the workings of gender and ethnic discrimination and reveals the importance of maternalism as a counterhegemonic perspective for Roma women.

    Secondly by investigating to what degree Roma women’s NGOs elaborate their programmes and initiatives in reference to broader gender equality frameworks. What are the economic dynamisms and dependencies behind NGO-isation and how do dependencies influence the processes of ideation of gender equality? Most importantly, the paper explores whether the ideation processes are empowering, participatory, bottom-up processes growing out of the culturally and socially specific conditions of the NGOs’ constituencies or are donor driven.

  • 15552.
    Asztalos Morell, Ildikó
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Uppsala Centre for Russian and Eurasian Studies. Mälardalen university.
    Workfare with a human face?: Innovative utilization of public work in rural municipalities in Hungary2014In: Metszetek, ISSN 2063-6415, Vol. 3, no 4, p. 4-24Article in journal (Refereed)
    Abstract [en]

    Public work is currently the major national tool for the reintegration of the long-term unemployed into the world of labour in Hungary. As a result of the expansion of resources the government allotted to facilitate public work employment, labour statistics improved substantially. Nonetheless, public labour as an institution is objected to intense criticism. Since employment as public worker is not bound to citizenship rights, local municipalities have a large degree of discretion about selecting whom they hire. Criticism most often focuses on employment discrimination. In contrast, this research takes a progressive municipality, with anti-discriminatory profile as an example, where public work was adapted as a welfare, rather than purely workfare praxis. Uszka, a rural small-sized municipality, is characterized by high ethnified unemployment. Its politicians and administrators adapted varied strategies to help combat poverty and unemployment. The paper explores the place of public work in the context of social policy instruments and poverty reduction strategies applied and the degrees of freedom and limitations municipalities have in adapting state instruments.

  • 15553.
    Asztalos Morell, Ildikó
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Carlbäck, Helene
    Gender Transitions in Russia and Eastern Europe2005Collection (editor) (Other (popular science, discussion, etc.))
  • 15554.
    Asztalos Morell, Ildikó
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Uppsala Centre for Russian and Eurasian Studies. Malardalen Univ, Sociol, Vasteras, Sweden.
    Gradskova, Yulia
    Sodertorn Univ, Hist, Huddinge, Sweden;Sodertorn Univ, Dept Gender Studies, Huddinge, Sweden;Sodertorn Univ, Ctr Baltic & East European Studies, Huddinge, Sweden.
    The gendered subject of postsocialism State-socialist legacies, global challenges and (re)building of tradition2018In: Gendering Postsocialism: Old Legacies and New Hierarchies / [ed] Gradskova, Y Morell, IA, Routledge, 2018, p. 1-17Conference paper (Refereed)
  • 15555.
    Asztalos Morell, Ildikó
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Sociology.
    Kovách Imre,
    Women´s Participation in the evolving post-socialist family farming. Paper presented at the Conference of the European society for rural Sociology, Crete 19971997Conference paper (Other scientific)
  • 15556.
    Asztalos Morell, Ildikó
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Uppsala Centre for Russian and Eurasian Studies.
    Tiurikova, Irina
    Single Men, Single Stories: Alternative Paths in the Transition from the Late Soviet to the Neoliberal Market Economy in the Light of Life Stories2014In: Debatte, ISSN 0965-156X, E-ISSN 1469-3712, Vol. 22, no 3, p. 329-351Article in journal (Refereed)
    Abstract [en]

    This research investigates life strategies of physical worker Russian men, belonging to the generation of people who were the most active group in the late Soviet period, went through the collapse of USSR and the transformation to capitalism. The historical biographic perspective allows reproducing common social experiences which have formed this generation. The in depth biographical interviews were conducted with six men of age 46-63, single, with officially low income, who started their working lives in the public sector. The research shows the diversity of men's alternative life strategies to adjust to the neoliberal economy established after the collapse of the USSR. The paper explores the biographies as representations of diverse forms of masculinities formed along gender, age, social position and marital status based marginalization processes emerging in the transition context.

  • 15557. Asztely, F.
    et al.
    Kumlien, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
    The diagnosis and treatment of limbic encephalitis2012In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 126, no 6, p. 365-375Article, review/survey (Refereed)
    Abstract [en]

    The term limbic encephalitis (LE) was first introduced in 1968. While this disease was initially considered rare and is often fatal with very few treatment options, several reports published in the last decade provide a better description of this condition as well as possible causes and some cases of successful treatment. The clinical manifestation of LE is primarily defined by the subacute onset of short-term memory loss, seizures, confusion and psychiatric symptoms suggesting the involvement of the limbic system. In addition, EEG often shows focal or generalized slow wave or epileptiform activity, and MRI findings reveal hyperintense signals of the medial temporal lobes in T2-weighted or FLAIR images. The current literature suggests that LE is not a single disorder but is comprised of a group of autoimmune disorders predominantly affecting the limbic system. Before the diagnosis of LE can be determined, other causes of subacute encephalopathy must be excluded, especially those resulting from infectious aetiologies. LE has previously been regarded as a paraneoplastic phenomenon associated with the classical onconeuronal antibodies that are primarily directed against intracellular antigens. However, recent literature suggests that LE is also associated with antibodies that are directed against cell surface antigens, and these cases of LE display a much weaker association to the neoplasm. The treatment options for LE largely depend on the aetiology of the disease and involve the removal of the primary neoplasm. Therefore, a search for the underlying tumour is mandatory. In addition, immunotherapy has been successful in a significant number of patients where LE is not associated with cancer.

  • 15558.
    Asén, Marianne
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Förskolechefers och specialpedagogers syn på barn i behov av särskilt stöd i förskolan: En intervjustudie2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Sammanfattning Syftet med denna undersökning är att belysa vissa förskolechefer och specialpedagogers upplevelser av arbetet kring barn i behov av särskilt stöd i förskolan, hur definition och identifiering sker, hur kompetensen hos personalen kan påverka identifiering, vilken kompetensutveckling som personalen får, hur specialpedagogen används i verksamheten och vilka andra aktörer som används i arbetet. Studien har genomförts utifrån semistrukturerade intervjuer med åtta förskolechefer/biträdande förskolechefer i två kommuner i södra Sverige och tre specialpedagoger i en kommun i södra Sverige. Studien visar att miljön och organisationen anses ha en stor betydelse i arbetet med barn i behov av särskilt stöd i förskolan. Studien visar också att specialpedagogn uppfattas som viktig i arbetet med barn i behov av särskilt stöd.  Dessutom anses de viktiga för att ge stöd åt personalen i förskolan. I studien har den socialkonstruktivistiska teorin använts. Den talar om att svårigheterna som barnen i behov av särskilt stöd har kan både vara socialt och/eller biologiskt konstruerade. Detta gör att de svårigheter som finns förstärks eller minskar beroende på vilken situation barnet befinner sig i när svårigheten uppstår.  I studien konstateras att det ute på förskolorna finns ett tänkande som gynnar barn i behov av särskilt stöd. Man ser till miljön och organisationen och inte till att det är barnets problem. Att förskolan ska vara tillgänglig och anpassad för alla barn verkar vara ett tänkande som dominerar i förskolan idag.  

  • 15559.
    Asén, Tom
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Caligulas efterträdare?: En kvalitativ studie om gymnasielärares yrkesidentiteter och sociala status2008Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 15560.
    Ata, A
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
    ) Expression of TGF-b isoforms, their receptors an related SMAD proteins in brain pathology. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine2000Other (Other scientific)
  • 15561.
    Ata, A K
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
    Funa, K
    Olsson, Y
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
    Expression of various TGF-beta isoforms and type I receptor in necrotizing human brain lesions.1997In: Acta Neuropath, Vol. 93, p. 326-Article in journal (Refereed)
  • 15562.
    Ata, Ahmad Khaled
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
    Expression of TGF- isoforms, their receptors and related SMAD proteins in brain pathology: Immunohistochemical studies focusing on infarcts, abscesses and malignant gliomas1999Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis focuses on the immunohistochemical expression of transforming growth factor beta(TGFβ) isoforms, their receptors and TGF-β-related SMAD proteins in brain pathology, chiefly in-farcts. One key question was whether the expressions of these compounds are altered within glial cells, endothelial cells of microvessels and other cell types in the vicinity of infarcts. Studies on human and animal brain infarcts were made. Immunoreactivities to TGF-β isoforms -β1, -β2 and -β3, and TGF-βreceptor (TβR) type I were seen in astrocytes, macrophages, neurons, endothelial and vascular smooth muscle cells of human brain infarcts. Similar observations were made in an experimental model of rat brain infarct at day 1 and 3 following occlusion of the middle cerebral artery (MCA). Increased expression of Smad2, -3, -4, -6 and -7 was seen already at 6 h after MCA occlusion in neurons, microvascular endothelial cells, astroglial cells and inflammatory cells. Later on, immunopositive macrophages were present in the infarcts. The changes persisted even at day 7 after MCA occlusion.

    Several alterations thus occur during the evolution of brain infarcts with regard to the immuno­histochemical expression of TGF-β, its receptors and related SMAD proteins. Such changes are, however, not unique to brain infarcts. Thus, patterns of high expression for TGF-β- isoforms -β1, -β2 -β3, and TβR-I in cases of brain abscess (human), and of Smad2, -3, -4, -6 and -7 in tumor cells and neoplastic blood vessels of malignant gliomas (human) were also observed.

    In addition, immunohistochemical expression of vascular endothelial growth factor (VEGF) andits receptors was investigated since this growth factor is involved in angiogenesis and edemaformation, two cardinal features of brain infarcts. Increased immunoreactivities, seen particularly in the edges of infarcts, were observed already at day 1 after MCA occlusion.

    In conclusion, the various TGF-β isoforms, receptors and related SMAD proteins, together with other factors, seem to be involved in the very complicated and important changes taking place in the vicinity of brain infarcts.

  • 15563.
    Ata, Ahmad Khaled
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
    Expression of TGF-beta Isoforms, Their Receptors and Related SMAD Proteins in Brain Pathology1999In: Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicin 855, 50pp, Uppsala. Dissertation for the Degree of Doctor of Medical Science in Pathology presentated at Uppsala UniversityOther (Other scientific)
  • 15564.
    Ata, Ghaderi
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Psychology.
    Psychometric properties of the Swedish version of Self-concept Questionnaire2005In: European journal of Psychological Assessment, Vol. 21, p. 139-146Article in journal (Refereed)
  • 15565.
    Ata, Ghaderi
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Psychology.
    The Foundation of the Self and the Assessment of Self-esteem2006In: The Concept of Self in Psychology, Nova Science Publishers , 2006Chapter in book (Other scientific)
  • 15566.
    Ata, Ghaderi
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Psychology.
    Ätstörningar2006In: Kognitiv beteendeterapi inom psykiatrin., Natur & Kultur , 2006Chapter in book (Other (popular scientific, debate etc.))
  • 15567.
    Ata, Ghaderi
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Psychology.
    Malin, Mårtensson
    Hanna, Schwan
    Primary prevention of eating disorders: A randomized trial of “everybody’s different” prevention program.2005In: Eating Disorders: The journal of Treatment and Prevention, Vol. 13, p. 245-259Article in journal (Refereed)
  • 15568.
    Ata, Humera
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    The quality of Antenatal care and its determinants in women of reproductive age in Pakistan: A cross-sectional study using Pakistan's Demographic Health survey data 2012-132016Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: Antenatal care (ANC) coverage rates have increased in Pakistan, but little is known about its quality. This study investigated the prevalence and factors associated with the quality of ANC in Pakistan.

    Methods: Based on cross-sectional data from Pakistan’s Demographic and Health Survey 2012-13, this study evaluated 5,522 women aged 15-49 years having at least one ANC consultation in their last pregnancy for the receipt of quality antenatal care. It was measured in terms of access and effectiveness (early initiation, four or more ANC visits, care by a skilled provider, and receipt of seven basic components of focused ANC) and was assessed for its association with structural, household, and individual factors. Sampling weights and generalized linear mixed-effects models were used.

    Results: ANC coverage was 71% and 38% for one and ≥ 4 visits, respectively. The prevalence of ANC quality was 11%. Higher household wealth and maternal educational level, older maternal age, lower gravidity status, and bad obstetric history significantly increased the odds of receiving quality care, whereas, living in Balochistan and Sindh provinces and attending non-formal care sources was associated with lower odds of getting quality care. Among the basic ANC components, blood pressure measurement was most frequently, whereas, health education was least frequently provided.

    Conclusions: Due to suboptimal quality, antenatal care in Pakistan is unlikely to achieve its potential to reduce the maternal and perinatal burden of disease. There is a dire need to address socio-demographic inequality in the receipt of quality ANC and to target the underprivileged.

  • 15569.
    Ata, KA
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
    Lennmyr, Fredrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Lennmyr, F
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Funa, K
    Olsson, Y
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
    Olsson, Y
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
    Terent, A
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Terent, A
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Expression of transforming growth factor-beta 1, 2, 3 isoforms and type I and II receptors in acute focal cerebral ischemia: an immunohistochemical study in rat after transient and permanent occlusion1999In: Acta Neuropathol., Vol. 97, p. 447-Article in journal (Refereed)
  • 15570.
    Atabaki, Korosh
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Department of Cell and Neurobiology, University of Southern California.
    Reinforcing effects of oxytocin in female rats: Intracerebroventricular self-administration2014Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    BACKGROUND: The neuropeptide oxytocin (OT) is involved in reproduction, promoting milk-ejection and uterine contractions. In addition, the hormone also stimulates social affiliation such as pair bonding and maternal attachment. In non-social settings, OT has anxiolytic, antidepressant and stress-reducing effects. Since affiliative behaviors are rewarding, this suggests that OT may enhance reward and reinforcement in a non-social context. If so, rats should be willing to work to obtain it. AIM: Test the hypothesis that a physiological dose of OT is reinforcing in a non-social setting. Intracerebroventricular (ICV) self-administration in female rats was used as the experimental model. METHODS: Ovariectomized female Long-Evans rats with estrogen replacement were implanted with an ICV cannula. Self-administration of oxytocin [1 ng in 1 ?l] or vehicle was conducted 4 h/day for 5 days/week, for a total of 30 days. RESULTS: Unlike vehicle controls, OT-treated rats showed a significant preference for the active lever. However, by RM-ANOVA there was no effect of OT, a significant effect of lever (active over inactive) and the OT x Lever interaction just missed significance. CONCLUSION: These results indicate that OT may be reinforcing. Future studies will test reinforcing effects of OT across a range of doses, and in the presence of a social partner. Reinforcement may be a mechanism by which OT promotes social behaviors, such as sexual and parental behavior, that are risky for the individual, but necessary for the species. The pro-social aspects of OT also have pharmaceutical implications, with the hormone being a possible treatment for social-deficit disorders such as autism. Similarly, OT may be effective against diminished emotional abilities, which are often observed in drug addicts.

  • 15571.
    Atabaki, Shamsolmolok
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Hur kan vi få alla med oss?: En undersökning om tre lärares tänkande, praktiker och uppfattningar kring inkluderande lärande, stimulans och en god lärar/elev relation2014Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Det huvudsakliga syftet med min examensuppsats var att undersöka hur man stimulerar, vad man gör och vilka undervisningsmetoder man använder sig av som lärare för att alla elever ska vara delaktiga i skolans dagliga arbete, med en särskild inriktning mot språket och ämnet svenska.

    Vidare var syftet att utforska hur lärare skapar och etablerar en god lärare/elevrelation i syfte till att främja undervisningen så att alla elever ska ta del av skolans dagliga arbete.

     

    Följande undersökningsmetoder har använts: lektionsobservationer, samt intervjuer.

    Jag har genomfört min undersökning i två olika klasser i årskurs 2-3 med tre lärare. Två av dessa lärare har huvudansvaret för varsin klass medan den tredje läraren jobbar som extraresurs. Klasserna har varit placerade i en skola i Mellansverige och vid intervjuerna har jag använt mig av öppna frågor. Mitt arbete bygger på fältstudier baserade på observationer och intervjuer angående lärares olika undervisningsstrategier och metoder, med betoning på arbete med en särskild inriktning mot språket och ämnet svenska.

     

    Med min undersökning har jag kommit fram till att några av de viktigaste faktorerna i en lyckad undervisning, eller med andra ord några av de viktigaste faktorerna för att väcka elevernas intresse för undervisningen och deras känsla av delaktighet, är hur den berörda läreren tänker och planerar sitt arbete och undervisningen samt att vilka  insatser sätts in av läraren för att eleverna ska nå målen på det bästa tänkbara sätt. Det är alltså viktigt hur den ansvarige läraren tänker och lägger upp undervisningen, planerar lektionerna med olika undervisningsmetoder och strategier, samt hur engagerad läraren är.

  • 15572.
    Atabaki-Pasdar, Naeimeh
    et al.
    Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, SE-20502 Malmo, Sweden..
    Ohlsson, Mattias
    Lund Univ, Dept Astron & Theoret Phys, Computat Biol & Biol Phys Unit, Lund, Sweden..
    Shungin, Dmitry
    Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, SE-20502 Malmo, Sweden..
    Kurbasic, Azra
    Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, SE-20502 Malmo, Sweden..
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Pearson, Ewan R.
    Univ Dundee, Med Res Inst, Div Cardiovasc & Diabet Med, Dundee, Scotland..
    Ali, Ashfaq
    Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, SE-20502 Malmo, Sweden..
    Franks, Paul W.
    Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, SE-20502 Malmo, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.;Harvard Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA..
    Statistical power considerations in genotype-based recall randomized controlled trials2016In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, article id 37307Article in journal (Refereed)
    Abstract [en]

    Randomized controlled trials (RCT) are often underpowered for validating gene-treatment interactions. Using published data from the Diabetes Prevention Program (DPP), we examined power in conventional and genotype-based recall (GBR) trials. We calculated sample size and statistical power for genemetformin interactions (vs. placebo) using incidence rates, gene-drug interaction effect estimates and allele frequencies reported in the DPP for the rs8065082 SLC47A1 variant, a metformin transported encoding locus. We then calculated statistical power for interactions between genetic risk scores (GRS), metformin treatment and intensive lifestyle intervention (ILI) given a range of sampling frames, clinical trial sample sizes, interaction effect estimates, and allele frequencies; outcomes were type 2 diabetes incidence (time-to-event) and change in small LDL particles (continuous outcome). Thereafter, we compared two recruitment frameworks: GBR (participants recruited from the extremes of a GRS distribution) and conventional sampling (participants recruited without explicit emphasis on genetic characteristics). We further examined the influence of outcome measurement error on statistical power. Under most simulated scenarios, GBR trials have substantially higher power to observe gene-drug and gene-lifestyle interactions than same-sized conventional RCTs. GBR trials are becoming popular for validation of gene-treatment interactions; our analyses illustrate the strengths and weaknesses of this design.

  • 15573.
    Atac, A
    et al.
    Uppsala University.
    Axelsson, A
    Uppsala University.
    Bearden, IG
    Uppsala University.
    Bergstrom, MH
    Uppsala University.
    Nyberg, J
    Uppsala University.
    Palacz, M
    Uppsala University.
    Persson, J
    Uppsala University.
    Piiparinen, M
    Uppsala University.
    Fahlander, C
    Uppsala University.
    Hagemann, GB
    Uppsala University.
    Herskind, B
    Uppsala University.
    Joss, DT
    Uppsala University.
    Leoni, S
    Uppsala University.
    Lipoglavsek, M
    Uppsala University.
    Nolan, PJ
    Uppsala University.
    Paul, ES
    Uppsala University.
    Redon, N
    Uppsala University.
    Roos, L
    Uppsala University.
    Semple, AT
    Uppsala University.
    Sletten, G
    Uppsala University.
    Tucek, K
    Uppsala University.
    Single-step link of the superdeformed band in Eu-1431996In: ZEITSCHRIFT FUR PHYSIK A-HADRONS AND NUCLEI, ISSN 0939-7922, Vol. 355, no 4, p. 343-344Article in journal (Other scientific)
    Abstract [en]

    A discrete gamma-ray transition with an energy of 3360.6 keV deexciting the second lowest SD state in Eu-143 has been discovered. It carries 3.2 % of the full intensity of the band and feeds into a nearly spherical state which is above the I = 35/2((+)),

  • 15574. Atac, A.
    et al.
    Kaskas, A
    Akkoyun, S
    Senyigit, M
    Huyuk, T
    Kara, O
    Nyberg, J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Discrimination of gamma rays due to inelastic neutron scattering in AGATA2009In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, E-ISSN 1872-9576, Vol. 607, no 3, p. 554-563Article in journal (Refereed)
    Abstract [en]

    Possibilities of discriminating neutrons and gamma rays in the AGATA gamma-ray tracking spectrometer have been investigated with the aim of reducing the background due to inelastic scattering of neutrons in the high-purity germanium crystals. This background may become a serious problem especially in experiments with neutron-rich radioactive ion beams. Simulations using the GEANT4 toolkit and a tracking program based on the forward tracking algorithm were carried out by emitting neutrons and gamma rays from the center of AGATA. Three different methods were developed and tested in order to find "fingerprints" of the neutron interaction points in the detectors. In a simulation with simultaneous emission of six neutrons with energies in the range 1-5 MeV and 10 gamma rays with energies between 150 and 1450 keV, the peak-to-background ratio at a gamma-ray energy of 1.0 MeV was improved by a factor of 2.4 after neutron rejection with a reduction of the photopeak efficiency at 1.0 MeV of only a factor of 1.25. (C) 2009 Elsevier B.V. All rights reserved.

  • 15575.
    Atac, Bilal
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Kartläggning av benzodiazepinanvändning och dess inverkan på fall-frakturhändelser, samt olämplig läkemedelsanvändning hos äldre2014Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Introduktion: Benzodiazepiner (BzD) och benzodiazepinliknande preparat (BzDLP) kan leda till beroende vid långtidsanvändning. En prövning för utsättning bör därför övervägas efter 4 veckors användning och utsättningen bör ske med utfasning vid långtidsanvändning. Tidigare studier är otillräckligt för att dra säkra slutsatser om BzD/BzDLPs inverkan på fall-frakturhändelser. Socialstyrelsen har sammanställt de substanser som inte är lämplig för användning av äldre personer om det inte finns särskilda skäl. Syftet med denna studie var att analysera läkemedelsbehandling hos äldre avseende följande områden: 1. Behandlingsfrekvens och behandlingslängd, samt utsättningsmetoden av BzD/BzDLP. 2. BzD/BzDLPs inverkan på fall-frakturhändelser. 3. Behandlingsfrekvens av Socialstyrelsens icke-rekommenderade preparat hos personer som är 75 år och äldre. Material och metoder: Journalerna för 84 patienter som behandlades på en geriatrisk avdelning i Uppsala län granskades under en 2 månaders period. Resultat: Behandlingsandel av BzD/BzDLP hos de undersökta patienterna var 80 procent och 70 procent av användningen skedde minst 5 veckor eller mer. Att byta ut preparatet med ett annat preparat, eller ändra stående ordination till vid behovsordination var den vanligaste utsättningsformen. BzD/BzDLP användningen var 49 procent vid fall-frakturhändelser i denna studie och Socialstyrelsens icke-rekommenderade läkemedelsbehandling förekom hos 14 procent av de icke-palliativa patienterna. Konklusion: Användning av BzD/BzDLP var högre hos deltagarna i studien, jämfört med användningen i riket. En större del av behandlingslängden var högre än Socialstyrelsens rekommendationer och utfasning vid utsättningen förekom inte. Inget samband mellan BzD/BzDLP och fall-frakturhändelser kunde ses i materialet. Den icke-rekommenderade läkemedelsanvändning var lägre hos deltagarna i studien jämfört med i riket.

  • 15576.
    Ataei Chegeni, Poya
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Rosvall, Olof
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Will you Marry mE?: hur uppstår långsiktiga relationer mellan onlinebaserade företag och deras kunder?2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    E-handeln har på mycket kort tid övergått från att vara ett komplement för säljare, till att bli en maktfaktor i sig på den globala marknadsplatsen. Forskning visar att fastän andelen konsumenter som handlar i fysiska butiker fortfarande har överhanden, uppvisar e- handelsbranschens enorma tillväxt långt större utvecklingsmöjligheter. Tidigare studier har granskat detta fenomen och utmaningar ur ett företagsperspektiv, där främst institutionella och kulturella aspekter av denna marknad har undersökts. Denna uppsats ämnar istället behandla fenomenet ur ett konsumentperspektiv, för att ta reda på hur långsiktiga relationer kan byggas mellan onlinebaserade företag och deras kunder, när de förstnämnda inte har fysiska butiker. Datainsamlingen skedde via fokusgruppsintervjuer med unga konsumenter som ofta handlar online, samt en kvalitativ intervju med VD:n för en onlinebaserad producent och försäljare av skor. Resultatet visade att långsiktiga relationer online är nästintill omöjliga att uppnå, bland annat då en fysisk koppling till företag fortfarande anses vara för vital för kunders tillit. Onlinebaserade måste, enligt denna studie, antingen tillhandahålla unika processer för kunden i konsumtionsprocessen, eller uppsöka fysiska lokaler för försäljning. 

  • 15577. Atak, Kaan
    et al.
    Engel, Nicholas
    Lange, Kathrin M.
    Golnak, Ronny
    Gotz, Malte
    Soldatov, Mikhail
    Rubensson, Jan-Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Soft X-Ray Physics.
    Kosugi, Nobuhiro
    Aziz, Emad F.
    The Chemical Bond in Carbonyl and Sulfinyl Groups Studied by Soft X-ray Spectroscopy and ab Initio Calculations2012In: ChemPhysChem, ISSN 1439-4235, E-ISSN 1439-7641, Vol. 13, no 13, p. 3106-3111Article in journal (Refereed)
    Abstract [en]

    The polar character of the sulfinyl bond, which determines many of the properties of dimethyl sulfoxide (DMSO), is a result of charge transfer in low-lying π-type orbitals. This characteristic—together with the wide energy gap between the highest occupied and the lowest unoccupied molecular orbitals of this substance—makes DMSO a relatively inert aprotic solvent with strong nucleophilicity and electrophilicity.

  • 15578. Ataman, Ozlem Uruk
    et al.
    Barrett, Ann
    Davidson, Susan
    De Haas-Kock, Danielle
    Dische, Stanley
    Dubray, Bernard
    Grillo, Isabel M
    Kramar, Andrew
    Haie-Meder, Christine
    Heeren, Germaine
    Hideghety, Katalin
    LeVay, John
    Maher, Jane
    Marcenaro, Michela
    Muller, Rolf-Peter
    Reguerio, Carlos A
    Saunders, Michele I
    Turesson, Ingela
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Enheten för onkologi.
    Van Houtte, Paul
    Vitale, Vito
    Audit of effectiveness of routine follow-up clinics after radiotherapy for cancer: a report of the REACT working group of ESTRO.2004In: Radiother Oncol, ISSN 0167-8140, Vol. 73, no 2, p. 237-49Article in journal (Other scientific)
  • 15579.
    Atanassov, Nikola
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Laying Down the Environmental Law Card: Could the Ecuadorian Approach be Developed as Viable Defence Mechanism for a Host State in International Investment Treaty Arbitration?2016Independent thesis Advanced level (degree of Master (One Year)), 12 HE creditsStudent thesis
  • 15580. Ataç, A.
    et al.
    Kaşkaş, A.
    Akkoyun, S.
    Şenyiğit, M.
    Hüyük, T.
    Kara, S. O.
    Nyberg, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Discrimination of gamma rays due to inelastic neutron scattering in AGATA2009In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, E-ISSN 1872-9576, Vol. 607, no 3, p. 554-563Article in journal (Refereed)
    Abstract [en]

    Possibilities of discriminating neutrons and γ rays in the AGATA γ -ray tracking spectrometer have been investigated with the aim of reducing the background due to inelastic scattering of neutrons in the high-purity germanium crystals. This background may become a serious problem especially in experiments with neutron-rich radioactive ion beams. Simulations using the Geant4 toolkit and a tracking program based on the forward tracking algorithm were carried out by emitting neutrons and γ rays from the center of AGATA. Three different methods were developed and tested in order to find “fingerprints” of the neutron interaction points in the detectors. In a simulation with simultaneous emission of six neutrons with energies in the range 1–5 MeV and 10 γ rays with energies between 150 and 1450 keV, the peak-to-background ratio at a γ -ray energy of 1.0 MeV was improved by a factor of 2.4 after neutron rejection with a reduction of the photopeak efficiency at 1.0 MeV of only a factor of 1.25.

  • 15581.
    Atesis, Dimitris
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Economic History.
    Jordbrukskooperationen i Grekland1984Independent thesis Basic level (degree of Bachelor)Student thesis
  • 15582.
    Atesok, Kivanc
    et al.
    University of Alabama at Birmingham, Birmingham, USA.
    Tanaka, Nobuhiro
    Hiroshima University, Hiroshima, Japan.
    O'Brien, Andrew
    Royal Victoria Hospital and Royal Belfast Hospital for Sick Children, Belfast, UK.
    Robinson, Yohan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Pang, Dachling
    University of California, Davis, USA; Kaiser Permanente Hospitals, Oakland, USA; Great Ormond Street Hospital For Children, London, UK.
    Deinlein, Donald
    University of Alabama at Birmingham, Birmingham, USA.
    Manoharan, Sakthivel Rajaram
    University of Alabama at Birmingham, Birmingham, USA.
    Pittman, Jason
    University of Alabama at Birmingham, Birmingham, USA.
    Theiss, Steven
    University of Alabama at Birmingham, Birmingham, USA.
    Posttraumatic Spinal Cord Injury without Radiographic Abnormality2018In: Advances in Orthopedics, ISSN 2090-3464, E-ISSN 2090-3472, Vol. 2018, article id 7060654Article, review/survey (Refereed)
    Abstract [en]

    “Spinal Cord Injury without Radiographic Abnormality” (SCIWORA) is a term that denotes objective clinical signs of posttraumatic spinal cord injury without evidence of fracture or malalignment on plain radiographs and computed tomography (CT) of the spine. SCIWORA is most commonly seen in children with a predilection for the cervical spinal cord due to the increased mobility of the cervical spine, the inherent ligamentous laxity, and the large head-to-body ratio during childhood. However, SCIWORA can also be seen in adults and, in rare cases, the thoracolumbar spinal cord can be affected too. Magnetic resonance imaging (MRI) has become a valuable diagnostic tool in patients with SCIWORA because of its superior ability to identify soft tissue lesions such as cord edema, hematomas and transections, and discoligamentous injuries that may not be visualized in plain radiographs and CT. The mainstay of treatment in patients with SCIWORA is nonoperative management including steroid therapy, immobilization, and avoidance of activities that may increase the risk of exacerbation or recurrent injury. Although the role of operative treatment in SCIWORA can be controversial, surgical alternatives such as decompression and fusion should be considered in selected patients with clinical and MRI evidence of persistent spinal cord compression and instability.

  • 15583.
    Ateva, Victoria
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Häktning av unga - Tortyr eller skälig åtgärd?: - En utredning kring lämpligheten i att använda häktning och restriktioner för unga lagöverträdare2016Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Europarådets kommitté mot tortyr CPT, har under 24 år kritiserat Sveriges hantering av häktning och restriktioner för unga lagöverträdare. Den senaste kritiken kom den 17 februari 2016 och avser CPT:s besök i Sverige året innan. Åter igen visade rapporten på stora brister i svenska häkten. Av barnombudsmannens och barnrättskommitténs kritik framgår vidare att ungas hälsa kan påverkas negativt under häktning då unga löper en ökad risk för att drabbas av psykisk ohälsa om de isoleras. Det är även vanligt att isolerade personer uppvisar psykosliknande tillstånd. Begränsning i kontakt med familj och vänner, är något som de unga häktade själva har uppgett är svårt att hantera då häktningen innebär en kris för den unge.

    Uppsatsens syfte är att undersöka om häktning av unga och åläggande av restriktioner för unga kan ses som tortyr eller om häktning av unga och åläggande av restriktioner för unga är en skälig åtgärd utifrån den kritik som presenteras i uppsatsen. Frågeställningarna som behandlas i uppsatsen är: Hur ser aktuell lagstiftning ut gällande häktning av unga och åläggande av restriktioner för unga? Kan häktning av unga samt att ålägga unga restriktioner ses som tortyr eller skälig åtgärd utifrån kritiken som har presenterats av barnombudsmannen, FN:s specialrapportör mot tortyr, barnrättskommittén, europarådets kommitté mot tortyr CPT samt häktes- och restriktionsutredningen?

    Uppsatsen visar att häktning av unga och åläggande av restriktioner för unga, inte kan ses som tortyr enligt tortyrkonventionens definition. Däremot kan häktning enligt tortyrkonventionen artikel 16 punkt 1 ses som omänsklig behandling eller bestraffning vilket konventionsstaterna så långt möjligt är skyldiga att förhindra. Barnombudsmannen och FN:s specialrapportör mot tortyr anser att effekterna av häktning av unga kan ses som tortyr när den unge isoleras längre än 15 dagar. Dessutom kan häktning och restriktioner för unga ses som omänsklig behandling enligt barnkonventionen, EKMR och tortyrkonventionen. Utifrån vad framställningen har visat är det sannolikt att Sverige kommer att förändra förfarandet kring häktning och restriktioner för unga. I augusti 2016 presenterar häktes- och restriktionsutredningen ett förslag om hur antalet häktningar och förekomsten av restriktioner kan minskas samt hur häktningstiderna kan förkortas för att på det sättet minska den pågående isoleringen i svenska häkten. Det är uppenbart att häktning och restriktioner mot unga är ett område som behöver utvecklas vidare. En önskvärd förändring skulle vara att Sverige tar kritiken som har lyfts fram på allvar och försöker förändra unga lagöverträdares vistelse i häkten för att minimera psykisk ohälsa bland unga lagöverträdare som häktas.

  • 15584.
    ATHANASIOU, THOMAS
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Multi-dimensional analysis of social multi-networks: Analysing a 5-layer social network case study2016Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Network theory analysis is applicable to many scientific disciplines (fields) such as biology, statistics and sociology. The social network analysis is one of the various branches of the broader network theory analysis, the social network analysis. It is of high interest among the researchers in social sciences. Social networks have had a significant impact on human civilizations for many centuries. During the last two decades, the main academic interest was addressed towards the research and analysis of a dynamically uprising sector of social networks, the on-line networks, primarily due to the domination of the Internet and technology over human attitudes and relations in modern societies. For many years, research was emphasized on the analysis of simple social networks, whilst during the last decade several researchers started working on the analysis of more complicated social networks, which consist by several smaller social networks.

    There are important differences between mono and multi-dimensional network analysis. Mono-dimensional analysis provides the research with relevant knowledge. On the other hand, multi-dimensional analysis is still at initial stage. As a result, several potential models related to the multi-networks analysis cannot always provide reliable and adequate outcomes. However, due to the fact that different social networks can be easily combined and form more extended and complicated networks, it is of high importance for the researchers to advance the multi-dimensional analysis and provide more adequate analytical models.

    The purpose of this thesis is to present the dynamic of the multi-dimensional analysis by consecutively applying both mono and multi-dimensional analysis on a social multi-network. The findings suggest that multi-dimensional analysis can add reliable knowledge on the social network analysis, but many problems that arose due the complexity of the multi-networks structures need to be addressed.

  • 15585.
    Athavan, N
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Theoretical Physics.
    Froman, PO
    Froman, N
    Lakshmanan, M
    Quantal two-center Coulomb problem treated by means of the phase-integral method. I. General theory2001In: JOURNAL OF MATHEMATICAL PHYSICS, ISSN 0022-2488, Vol. 42, no 11, p. 5051-5076Article in journal (Refereed)
    Abstract [en]

    The present paper concerns the derivation of phase-integral quantization conditions for the two-center Coulomb problem under the assumption that the two Coulomb centers are fixed. With this restriction we treat the general two-center Coulomb problem accor

  • 15586.
    Athavan, N
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Theoretical Physics.
    Lakshmanan, M
    Froman, N
    Quantal two-center Coulomb problem treated by means of the phase-integral method. II. Quantization conditions in the symmetric case expressed in terms of complete elliptic integrals. Numerical illustration2001In: JOURNAL OF MATHEMATICAL PHYSICS, ISSN 0022-2488, Vol. 42, no 11, p. 5077-5095Article in journal (Refereed)
    Abstract [en]

    The contour integrals, occurring in the arbitrary-order phase-integral quantization conditions given in a previous paper, are in the first- and third-order approximations expressed in terms of complete elliptic integrals in the case that the charges of th

  • 15587.
    Athavan, N
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Theoretical Physics.
    Lakshmanan, M
    Froman, N
    Quantal two-center Coulomb problem treated by means of the phase-integral method. III. Quantization conditions in the general case expressed in terms of complete elliptic integrals. Numerical illustration2001In: JOURNAL OF MATHEMATICAL PHYSICS, ISSN 0022-2488, Vol. 42, no 11, p. 5096-5115Article in journal (Refereed)
    Abstract [en]

    In this paper we take up the quantal two-center problem where the Coulomb centers have arbitrary positive charges. In analogy with the symmetric case, treated in the second paper of this series, we use the knowledge on the quasiclassical dynamics to expre

  • 15588. Athlin, Simon
    et al.
    Kaltoft, Margit
    Slotved, Hans-Christian
    Herrmann, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Bacteriology.
    Holmberg, Hans
    Konradsen, Helle Bossen
    Stralin, Kristoffer
    Association between Serotype-Specific Antibody Response and Serotype Characteristics in Patients with Pneumococcal Pneumonia, with Special Reference to Degree of Encapsulation and Invasive Potential2014In: Clinical and Vaccine Immunology, ISSN 1556-6811, E-ISSN 1556-679X, Vol. 21, no 11, p. 1541-1549Article in journal (Refereed)
    Abstract [en]

    We studied the immunoglobulin (Ig) response to causative serotype-specific capsular polysaccharides in adult pneumococcal pneumonia patients. The serotypes were grouped according to their degree of encapsulation and invasive potential. Seventy patients with pneumococcal pneumonia, 20 of whom were bacteremic, were prospectively studied. All pneumococcal isolates from the patients were serotyped, and the Ig titers to the homologous serotype were determined in acute-and convalescent-phase sera using a serotype-specific enzyme-linked immunosorbent assay. The Ig titers were lower in bacteremic cases than in nonbacteremic cases (P < 0.042). The Ig titer ratio (convalescent/acute titer) was >= 2 in 33 patients, 1 to 1.99 in 20 patients, and < 1 in 17 patients. Patients >= 65 years old had a lower median Ig titer ratio than did younger patients (P < 0.031). The patients with serotypes with a thin capsule (1, 4, 7F, 9N, 9V, and 14) and medium/high invasive potential (1, 4, 7F, 9N, 9V, 14, and 18C) had higher Ig titer ratios than did patients with serotypes with a thick capsule (3, 6B, 11A, 18C, 19A, 19F, and 23F) and low invasive potential (3, 6B, 19A, 19F, and 23F) (P < 0.05 for both comparisons after adjustment for age). Ig titer ratios of <1 were predominantly noted in patients with serotypes with a thick capsule. In 8 patients with pneumococcal DNA detected in plasma, the three patients with the highest DNA load had the lowest Ig titer ratios. In conclusion, a high antibody response was associated with serotypes with a thin capsule and medium/high invasive potential, although a low antibody response was associated with serotypes with a thick capsule and a high pneumococcal plasma load.

  • 15589.
    Athlin, Åsa Muntlin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Health Services Research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Univ Uppsala Hosp, Dept Emergency Care & Internal Med, Entrance 40, S-75185 Uppsala, Sweden.;Univ Adelaide, Sch Nursing, Adelaide, SA, Australia..
    Engström, Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences. Univ Gavle, Fac Hlth & Occupat Studies, Dept Hlth & Caring Sci, Gavle, Sweden.;Lishui Univ, Sch Med & Hlth, Dept Nursing, Lishui, Peoples R China..
    Gunningberg, Lena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences. Univ Uppsala Hosp, Qual Dept, Uppsala, Sweden..
    Baath, Carina
    Karlstad Univ, Fac Hlth Sci & Technol, Dept Hlth Sci, Karlstad, Sweden.;Cty Council Varmland, Karlstad, Sweden..
    Heel pressure ulcer, prevention and predictors during the care delivery chain - when and where to take action?: A descriptive and explorative study2016In: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, ISSN 1757-7241, E-ISSN 1757-7241, Vol. 24, article id 134Article in journal (Refereed)
    Abstract [en]

    Background: Hazardous healthcare settings, for example acute care, need to focus more on preventing adverse events and preventive actions across the care delivery chain (i.e pre-hospital and emergency care, and further at the hospital ward) should be more studied. Pressure ulcer prevalence is still at unreasonably high levels, causing increased healthcare costs and suffering for patients. Recent biomedical research reveals that the first signs of cell damage could arise within minutes. However, few studies have investigated optimal pressure ulcer prevention in the initial stage of the care process, e.g. in the ambulance care or at the emergency department. The aim of the study was to describe heel pressure ulcer prevalence and nursing actions in relation to pressure ulcer prevention during the care delivery chain, for older patients with neurological symptoms or reduced general condition. Another aim was to investigate early predictors for the development of heel pressure ulcer during the care delivery chain. Methods: Existing data collected from a multi-centre randomized controlled trial investigating the effect of using a heel prevention boot to reduce the incidence of heel pressure ulcer across the care delivery chain was used. Totally 183 patients participated. The settings for the study were five ambulance stations, two emergency departments and 16 wards at two hospitals in Sweden. Results: A total of 39 individual patients (21 %) developed heel pressure ulcer at different stages across the care delivery chain. Findings revealed that 47-64 % of the patients were assessed as being at risk for developing heel pressure ulcer. Preventive action was taken. However, all patients who developed pressure ulcer during the care delivery chain did not receive adequate pressure ulcer prevention actions during their hospital stay. Discussion and Conclusions: In the ambulance and at the emergency department, skin inspection seems to be appropriate for preventing pressure ulcer. However, carrying out risk assessment with a validated instrument is of significant importance at the ward level. This would also be an appropriate level of resource use. Context-specific actions for pressure ulcer prevention should be incorporated into the care of the patient from the very beginning of the care delivery chain.

  • 15590.
    Athlin, Åsa Muntlin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Health Services Research.
    Farrokhnia, N.
    Schwarz, U. von Thiele
    Introduction of multi-professional teamwork: a promising approach towards a more patient-centred care in the emergency department2014In: International Emergency Nursing, ISSN 1755-599X, E-ISSN 1878-013X, Vol. 22, no 4, p. 274-275Article in journal (Other academic)
  • 15591.
    Athlin, Åsa Muntlin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Health Services Research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Univ Adelaide, Sch Nursing, Adelaide, SA, Australia..
    Juhlin, Claes
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
    Jangland, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Education in Nursing.
    Lack of existing guidelines for a large group of patients in Sweden: a national survey across the acute surgical care delivery chain2017In: Journal of Evaluation In Clinical Practice, ISSN 1356-1294, E-ISSN 1365-2753, Vol. 23, no 1, p. 89-95Article in journal (Refereed)
    Abstract [en]

    Rationale, aims and objectivesEvidence-informed healthcare is the fundament for prac-tice, whereby guidelines based on the best available evidence should assist health profes-sionals in managing patients. Patients seeking care for acute abdominal pain form acommon group in acute care settings worldwide, for whom decision-making and timelytreatment are of paramount importance. There is ambiguity about the existence, use andcontent of guidelines for patients with acute abdomen. The objective was to describe andcompare guidelines and management of patients with acute abdomen in different settingsacross the acute care delivery chain in Sweden.MethodA national cross-sectional design was used. Twenty-nine ambulance stations, 17emergency departments and 33 surgical wards covering all six Swedish health regions wereincluded, and 23 guidelines were quality appraised using the validated Appraisal of Guide-lines for Research & Evaluation II tool.ResultsThere is a lack of guidelines in use for the management of this large group of pa-tients between and within different healthcare areas across the acute care delivery chain.The quality appraisal identified that several guidelines were of poor quality, especiallythe in-hospital ones. Further, range orders for analgesics are common in the ambulance ser-vices and the surgical wards, but are seldom present in the emergency departments. Also,education in pain management is more common in the ambulance services. Thesefindingsare noteworthy as, hypothetically, the same patient could be treated in three different waysduring the same care episode.ConclusionsThere is an urgent need to develop high-quality evidence-based clinicalguidelines for this patient group, with the entire care process in focus

  • 15592. Atienza-Párraga, Alba
    et al.
    Diamanti, Klev
    Nylund, Patrick
    Skaftason, Aron
    Ma, Anqi
    Jin, Jian
    Martín-Subero, José Ignacio
    Öberg, Fredrik
    Komorowski, Jan
    Jernberg-Wiklund, Helena
    Kalushkova, Antonia
    Epigenomic re-configuration of primary multiple myeloma underlies the synergistic effect of combined DNMT and EZH2 inhibition.Manuscript (preprint) (Other academic)
    Abstract [en]

    Multiple myeloma (MM) is characterized by an overexpression of EZH2 and a subsequent increase in H3K27me3-mediated silencing. However, the genome-wide redistribution of this mark in context with other epigenetic tags remains largely unexplored. Here, we show that EZH2 physically interacts with DNMT1 and that combined inhibition leads to a reduced G2/M arrest and increased apoptosis in MM. In addition, we present a catalogue of the genomic regulatory regions in normal plasma cells (NPC) as defined by their individual combination of histone marks. We used ChIP-seq and ATAC-seq data to generate whole-genome NPC chromatin annotations which we further analysed using DNA methylation arrays and RNA-seq. Comparison between NPC and MM demonstrated that, despite the global hypomethylation, enhancers show a tendency towards a higher DNA methylation levels in MM, whereas Polycomb and heterochromatic sites, highly methylated in NPC, show intermediate levels of the mark. Across all examined regulatory regions, 5-azacytidine treatment strongly reduced DNA methylation in MM. Furthermore, we find an extensive re-structuration of the global histone patterns in MM. We noticed a widespread increase in H3K27me3 except at active TSSs/promoters and enhancers, where we found a selective gain of the mark, suggestive of a directed silencing. In contrast, poised TSSs lose H3K27me3 and gain the activation mark H3K27ac, reflecting potential activation. Taken together, we present a comprehensive map of the epigenomic changes in MM as compared to NPC and provide insights into the interplay between EZH2 and DNMT1 in MM.

  • 15593.
    Atif, Abdul Raouf
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Carter, Sarah-Sophia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Pujari-Palmer, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Tenje, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Mestres, Gemma
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Bone Cement Embedded in a Microfluidic Device2018Conference paper (Refereed)
    Abstract [en]

    Calcium phosphate cements (CPCs) have a great potential in the treatment of bone disorders due to their excellent biocompatibility. Although CPCs are promising when implanted in vivo, there is poor correlation between in vitro and in vivo studies. This could be because most conventional in vitro systems lack a 3D architecture, or dynamic conditions (i.e. a continuous refreshment stream). The aim of this work is to embed CPCs into a microfluidic system and evaluate ion and protein exchange at different flow rates.

  • 15594.
    Atig, Mohamed Faouzi
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    From multi to single stack automata2010In: CONCUR 2010 – Concurrency Theory, Berlin: Springer-Verlag , 2010, p. 117-131Conference paper (Refereed)
  • 15595.
    Atig, Mohamed Faouzi
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    Global model checking of ordered multi-pushdown systems2010In: IARCS Annual Conference on Foundations of Software Technology and Theoretical Computer Science: FSTTCS 2010, Dagstuhl, Germany: Leibniz-Zentrum für Informatik , 2010, p. 216-227Conference paper (Refereed)
  • 15596.
    Atig, Mohamed Faouzi
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    Model-Checking of Ordered Multi-Pushdown Automata2012In: Logical Methods in Computer Science, ISSN 1860-5974, E-ISSN 1860-5974, Vol. 8, no 3, p. 20-Article in journal (Refereed)
    Abstract [en]

    We address the verification problem of ordered multi-pushdown automata: A multi-stack extension of pushdown automata that comes with a constraint on stack transitions such that a pop can only be performed on the first non-empty stack. First, we show that the emptiness problem for ordered multi-pushdown automata is in 2ETIME. Then, we prove that, for an ordered multi-pushdown automata, the set of all predecessors of a regular set of configurations is an effectively constructible regular set. We exploit this result to solve the global model-checking which consists in computing the set of all configurations of an ordered multi-pushdown automaton that satisfy a given w-regular property (expressible in linear-time temporal logics or the linear-time mu-calculus). As an immediate consequence, we obtain an 2ETIME upper bound for the model-checking problem of w-regular properties for ordered multi-pushdown automata (matching its lower-bound).

  • 15597.
    Atig, Mohamed Faouzi
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    Bensalem, SaddekBliudze, SimonMonsuez, Bruno
    Verification and Evaluation of Computer and Communication Systems2018Conference proceedings (editor) (Other academic)
  • 15598.
    Atig, Mohamed Faouzi
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    Bollig, Benedikt
    CNRS, LSV, Paris, France.;ENS Paris Saclay, Paris, France.
    Habermehl, Peter
    CNRS, IRIF, Paris, France.;Univ Paris Diderot, Paris, France..
    Emptiness of Ordered Multi-Pushdown Automata is 2ETIME-Complete2017In: International Journal of Foundations of Computer Science, ISSN 0129-0541, Vol. 28, no 8, p. 945-975Article in journal (Refereed)
    Abstract [en]

    We consider ordered multi-pushdown automata, a multi-stack extension of pushdown automata that comes with a constraint on stack operations: a pop can only be performed on the first non-empty stack (which implies that we assume a linear ordering on the collection of stacks). We show that the emptiness problem for multi-pushdown automata is 2ETIME-complete. Containment in 2ETIME is shown by translating an automaton into a grammar for which we can check if the generated language is empty. The lower bound is established by simulating the behavior of an alternating Turing machine working in exponential space. We also compare ordered multi-pushdown automata with the model of bounded-phase (visibly) multi-stack pushdown automata, which do not impose an ordering on stacks, but restrict the number of alternations of pop operations on different stacks.

  • 15599.
    Atig, Mohamed Faouzi
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    Bouajjani, Ahmed
    Burckhardt, Sebastian
    Musuvathi, Madanlal
    On the verification problem for weak memory models2010In: Proc. 37th ACM Symposium on Principles of Programming Languages, New York: ACM Press , 2010, p. 7-18Conference paper (Refereed)
  • 15600.
    Atig, Mohamed Faouzi
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    Bouajjani, Ahmed
    Burckhardt, Sebastian
    Musuvathi, Madanlal
    What's decidable about weak memory models?2012In: Programming Languages and Systems, Springer Berlin/Heidelberg, 2012, p. 26-46Conference paper (Refereed)
    Abstract [en]

    We investigate the decidability of the state reachability problem in finite-state programs running under weak memory models. In [3], we have shown that this problem is decidable for TSO and its extension with the write-to-write order relaxation, but beyond these models nothing is known to be decidable. Moreover, we have shown that relaxing the program order by allowing reads or writes to overtake reads leads to undecidability. In this paper, we refine these results by sharpening the (un)decidability frontiers on both sides. On the positive side, we introduce a new memory model NSW (for non-speculative writes) that extends TSO with the write-to-write relaxation, the read-to-read relaxation, and support for partial fences. We present a backtrack-free operational model for NSW, and prove that it does not allow causal cycles (thus barring pathological out-of-thin-air effects). On the negative side, we show that adding the read-to-write relaxation to TSO causes undecidability, and that adding non-atomic writes to NSW also causes undecidability. Our results establish that NSW is the first known hardware-centric memory model that is relaxed enough to permit both delayed execution of writes and early execution of reads for which the reachability problem is decidable.

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