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  • 15551.
    Aspengren, Henrik Chetan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    Pedagogik och politik i formandet av en indisk nation2012In: Historisk Tidskrift (S), ISSN 0345-469X, Vol. 132, no 4, p. 684-688Article, book review (Other academic)
  • 15552. Aspengren, Henrik Chetan
    Social Imperialism: How it was applied in the Bombay Presidency 1895-19252010Doctoral thesis, monograph (Other academic)
  • 15553.
    Aspengren, Karl
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Världens roligaste sommarjobb!: En studie av Gröna Lunds arbetsgivarvarumärke2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 15554.
    Aspengren, Lisa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Ensamkommande marockanska barns rätt till uppehållstillstånd: en fråga om asyl och praktiska verkställighetshinder2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • 15555. Aspenstrom-Fagerlund, Bitte
    et al.
    Tallkvist, Jonas
    Ilbäck, Nils-Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine.
    Glynn, Anders W.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Oleic acid increases intestinal absorption of the BCRP/ABCG2 substrate, mitoxantrone, in mice2015In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 237, no 2, p. 133-139Article in journal (Refereed)
    Abstract [en]

    The efflux transporter breast cancer resistance protein (BCRP/ABCG2) decrease intestinal absorption of many food toxicants. Oleic acid increases absorption of the specific BCRP substrate mitoxantrone (MXR), and also BCRP gene expression in human intestinal Caco-2 cells, suggesting that oleic acid affect the BCRP function. Here, we investigated the effect of oleic acid on intestinal absorption of MXR in mice. Mice were orally dosed with 2.4 g oleic acid/kg b.w. and 1 mg MXR/kg b.w., and sacrificed 30, 60, 90 or 120 min after exposure, or were exposed to 0.6, 2.4 or 4.8 g oleic acid/kg b.w. and 1mg MXR/kg b.w., and sacrificed 90 min after exposure. Mice were also treated with Ko143 together with MXR and sacrificed after 60 min, as a positive control of BCRP-mediated effects on MXR absorption. Absorption of MXR increased after exposure to oleic acid at all doses, and also after exposure to Ko143. Intestinal BCRP gene expression tended to increase 120 min after oleic acid exposure. Our results in mice demonstrate that oleic acid decreases BCRP-mediated efflux, causing increased intestinal MXR absorption in mice. These findings may have implications in humans, concomitantly exposed to oleic acid and food contaminants that, similarly as MXR, are substrates of BCRP.

  • 15556.
    Aspenström, Pontus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
    Activated Rho GTPases in Cancer-The Beginning of a New Paradigm2018In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 19, no 12, article id 3949Article, review/survey (Refereed)
    Abstract [en]

    Involvement of Rho GTPases in cancer has been a matter of debate since the identification of the first members of this branch of the Ras superfamily of small GTPases. The Rho GTPases were ascribed important roles in the cell, although these were restricted to regulation of cytoskeletal dynamics, cell morphogenesis, and cell locomotion, with initially no clear indications of direct involvement in cancer progression. This paradigm has been challenged by numerous observations that Rho-regulated pathways are often dysregulated in cancers. More recently, identification of point mutants in the Rho GTPases Rac1, RhoA, and Cdc42 in human tumors has finally given rise to a new paradigm, and we can now state with confidence that Rho GTPases serve as oncogenes in several human cancers. This article provides an expose of current knowledge of the roles of activated Rho GTPases in cancers.

  • 15557.
    Aspenström, Pontus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
    Expression of ß-actin and human profilin in the yeast Saccharomyces cerevisiae: isolation and characterization of site-specific actin mutants1992Doctoral thesis, comprehensive summary (Other academic)
  • 15558.
    Aspenström, Pontus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Integration of signalling pathways regulated by small GTPases and calcium2004In: Biochimica et Biophysica Acta, ISSN 0006-3002, E-ISSN 1878-2434, Vol. 1742, no 1-3, p. 51-58Article, review/survey (Refereed)
    Abstract [en]

    The Ras superfamily of small GTPases constitutes a large group of structurally and functionally related proteins. They function as signalling switches in numerous signalling cascades in the cell. During the recent years, an increased awareness of a communication between signalling systems employing Ras-like GTPases and signalling systems employing calcium has emerged. For instance, the intensity of the activation of Ras-like GTPases is regulated by calcium-dependent mechanisms, acting on proteins that facilitate the activation or inactivation of the small GTPases. Other Ras-like GTPases have a direct influence on calcium signalling by regulating the activity of certain calcium channels. In addition, several small GTPases collaborate with calcium signalling in regulating cellular processes, such as cell adhesion, cell migration and exocytosis.

  • 15559.
    Aspenström, Pontus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    Roles of F-BAR/PCH Proteins in the Regulation of Membrane Dynamics and Actin Reorganization2009In: International Review of Cell and Molecular Biology, Vol. 272, p. 1-31Article, review/survey (Refereed)
    Abstract [en]

    The Pombe Cdc15 Homology (PCH) proteins have emerged in many species as important coordinators of signaling pathways that regulate actomyosin assembly and membrane dynamics. The hallmark of the PCH proteins is the presence of a Fes/ClP4 homology-Bin/Amphiphysin/Rvsp (F-BAR) domain; therefore they are commonly referred to as F-BAR proteins. The prototype F-BAR protein, Cdc15p of Schizosaccharomyces pombe, has a role in the formation of the contractile actomyosin ring during cytokinesis. Vertebrate F-BAR proteins have an established role in binding phospholipids and they participate in membrane deformations, for instance, during the internalization of transmembrane receptors. This way the F-BAR proteins will function as linkers between the actin polymerization apparatus and the machinery regulating membrane dynamics. Interestingly, some members of the F-BAR proteins are implicated in inflammatory or neurodegenerative disorders and the observations can be expected to have clinical implications for the treatment of the diseases.

  • 15560.
    Aspenström, Pontus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    The mammalian verprolin homologue WIRE participates in receptor-mediated endocytosis and regulation of the actin filament system by distinct mechanisms2004In: Experimental Cell Research, ISSN 0014-4827, E-ISSN 1090-2422, Vol. 298, no 2, p. 485-498Article in journal (Refereed)
    Abstract [en]

    The mammalian verprolin family consists of three family members: WIP, WIRE and CR16. WIRE was recently found to bind to WASP and N-WASP and to have roles in regulating actin dynamics downstream of the platelet-derived growth factor beta-receptor. In the current study, the WASP-binding domain of WIRE was identified, with the core of the binding motif encompassing amino acid residues 408-412. A stretch of aromatic amino acid residues close to the core motif also participates in WASP binding. Amino acid substitutions in each of these motifs abrogated WASP binding, suggesting that both motifs are involved in the binding of WIRE to WASP. Interestingly, WIRE mutants unable to bind WASP were still able to induce a reorganisation of the actin filament system, indicating that WASP did not participate in the signalling pathway that link WIRE to actin dynamics. In cells ectopically expressing WIRE, the endocytosis of the platelet-derived growth factor beta-receptor was drastically reduced. However, in contrast to the effect on the actin filament system, the WIRE-induced ablation of the receptor endocytosis required an intact WASP-binding domain. Moreover, WIRE was more efficient than WIP in inhibiting the receptor endocytosis, implicating that these two mammalian verprolins have distinct roles in mammalian cells.

  • 15561.
    Aspenström, Pontus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    The verprolin family of proteins: Regulators of cell morphogenesis and endocytosis2005In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 579, no 24, p. 5253-5259Article, review/survey (Refereed)
    Abstract [en]

    The verprolin family of proteins, WIP, CR16 and WIRE/WICH, has emerged as critical regulators of cytoskeletal organisation in vertebrate cells. The founding father of the family, verprolin, was originally identified in budding yeast and later shown to be needed for actin polymerisation during polarised growth and during endocytosis. The vertebrate verprolins regulate actin dynamics either by binding directly to actin, by binding the WASP family of proteins or by binding to other actin regulating proteins. Interestingly, also the vertebrate verprolins have been implicated in endocytosis, demonstrating that most of the functional modules in this fascinating group of proteins have been conserved from yeast to man.

  • 15562.
    Aspenström, Pontus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    The verprolins as regulators of actin dynamics.2006In: Actin-monomer-binding proteins., Austin, Texas: Landes Biosciences , 2006, p. 97-106Chapter in book (Refereed)
    Abstract [en]

    Verprolin is an actin-binding protein first identified in budding yeast Saccharomyces cerevisiae. The yeast verprolin is needed for actin polymerisation during polarised growth and during endocytosis. In vertebrate cells, three genes encoding Verprolin orthologues have been identified: WIP, CR16 and WIRE/WICH. The mammalian verprolins have been implicated in the regulation of actin dynamics either by binding directly to actin, by binding the WASP family of proteins or by binding to other actin regulating proteins. This review article will bring up to discussion the current understanding of the mechanisms underlying verprolin-dependent mobilisation of the actin filament system.

  • 15563.
    Aspenström, Pontus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor2002In: Experimental Cell Research, ISSN 0014-4827, E-ISSN 1090-2422, Vol. 279, no 1, p. 21-33Article in journal (Refereed)
    Abstract [en]

    Activation of growth factor receptors, such as platelet-derived growth factor (PDGF) receptors, has a major impact on the motile behavior of vertebrate cells. The WASP family of proteins has been recognized as important regulators of actin polymerization via the activation of the Arp2/3 complex. The activity of the WASP proteins has, in turn, been shown to be governed by a number of associated proteins, including the WASP interacting protein (WIP). This report presents a novel WIP-like protein, WIRE (for WIP-related). WIRE was shown to bind to the WH1 domain of WASP and N-WASP. WIRE was localized to actin filaments in transiently transfected PAE/PDGFRbeta cells, and in cells simultaneously expressing WIRE and WASP, WIRE relocalized WASP to actin filaments, a relocalization that required direct interaction between the two proteins. In addition, WIRE was able to bind the PDGF receptor substrate Nckbeta. PDGF treatment of cells ectopically expressing WIRE resulted in formation of peripheral protrusions composed of filopodia and lamellipodia-like structures. In cells expressing both WIRE and WASP, PDGF treatment induced a translocation of WASP to the cell margin, an effect that required the presence of WIRE. Taken together, the data presented indicate that WIRE has a role in the WASP-mediated organization of the actin cytoskeleton and that WIRE is a potential link between the activated PDGF receptor and the actin polymerization machinery.

  • 15564.
    Aspenström, Pontus
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    Fransson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    Richnau, Ninna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeleton2006In: TIBS -Trends in Biochemical Sciences. Regular ed., ISSN 0968-0004, E-ISSN 1362-4326, Vol. 31, no 12, p. 670-679Article, review/survey (Refereed)
    Abstract [en]

    Pombe Cdc15 homology (PCH) proteins have emerged in many species as important coordinators of signalling pathways that regulate actomyosin assembly and membrane dynamics. For example, the prototype PCH protein, Cdc15p of Schizosaccharomyces pombe, has a role in assembly of the contractile ring, which is needed to separate dividing cells. Recently, mammalian PCH proteins have been found to bind phospholipids and to participate in membrane deformation. These findings suggest that PCH proteins are crucial linkers of membrane dynamics and actin polymerization, for example, during the internalization of transmembrane receptors. Intriguingly, some members of the PCH protein family are mutated in neurodegenerative and inflammatory diseases, which has implications for the identification of cures for such disorders.

  • 15565. Aspenström, Pontus
    et al.
    Fransson, Åsa
    Uppsala University, Units outside the University, Ludwig Institute for Cancer Research.
    Saras, Jan
    Rho GTPases have diverse effects on the organization of the actin filament system2004In: Biochem J, Vol. 337, no Pt 2, p. 327-337Article in journal (Refereed)
  • 15566.
    Aspenström, Pontus
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    Fransson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    Saras, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Rho GTPases have diverse effects on the organization of the actin filament system2004In: Biochemical Journal, ISSN 0264-6021, E-ISSN 1470-8728, Vol. 377, no Pt 2, p. 327-337Article in journal (Refereed)
    Abstract [en]

    The Rho GTPases are related to the Ras proto-oncogenes and consist of 22 family members. These proteins have important roles in regulating the organization of the actin filament system, and thereby the morphogenesis of vertebrate cells as well as their ability to migrate. In an effort to compare the effects of all members of the Rho GTPase family, active Rho GTPases were transfected into porcine aortic endothelial cells and the effects on the actin filament system were monitored. Cdc42, TCL (TC10-like), Rac1-Rac3 and RhoG induced the formation of lamellipodia, whereas Cdc42, Rac1 and Rac2 also induced the formation of thick bundles of actin filaments. In contrast, transfection with TC10 or Chp resulted in the formation of focal adhesion-like structures, whereas Wrch-1 induced long and thin filopodia. Transfection with RhoA, RhoB or RhoC induced the assembly of stress fibres, whereas Rnd1-Rnd3 resulted in the loss of stress fibres, but this effect was associated with the formation of actin- and ezrin-containing dorsal microvilli. Cells expressing RhoD and Rif had extremely long and flexible filopodia. None of the RhoBTB or Miro GTPases had any major influence on the organization of the actin filament system; instead, RhoBTB1 and RhoBTB2 were present in vesicular structures, and Miro-1 and Miro-2 were present in mitochondria. Collectively, the data obtained in this study to some extent confirm earlier observations, but also allow the identification of previously undetected roles of the different members of the Rho GTPases.

  • 15567.
    Aspenström, Pontus
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Richnau, Ninna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Johansson, Ann-Sofi
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics2006In: Experimental Cell Research, ISSN 0014-4827, E-ISSN 1090-2422, Vol. 312, no 12, p. 2180-2194Article in journal (Refereed)
    Abstract [en]

    Binding partners for the Cdc42 effector CIP4 were identified by the yeast two-hybrid system, as well as by testing potential CIP4-binding proteins in coimmunoprecipitation experiments. One of the CIP4-binding proteins, DAAM1, was characterised in more detail. DAAM1 is a ubiquitously expressed member of the mammalian diaphanous-related formins, which include proteins such as mDia1 and mDia2. DAAM1 was shown to bind to the SH3 domain of CIP4 in vivo. Ectopically expressed DAAM1 localised in dotted pattern at the dorsal side of transfected cells and the protein was accumulated in the proximity to the microtubule organising centre. Moreover, ectopic expression of DAAM1 induced a marked alteration of the cell morphology, seen as rounding up of the cells, the formation of branched protrusions as well as a reduction of stress-fibres in the transfected cells. Coimmunoprecipitation experiments demonstrated that DAAM1 bound to RhoA and Cdc42 in a GTP-dependent manner. Moreover, DAAM1 was found to interact and collaborate with the non-receptor tyrosine kinase Src in the formation of branched protrusions. Taken together, our data indicate that DAAM1 communicates with Rho GTPases, CIP4 and Src in the regulation of the signalling pathways that co-ordinate the dynamics of the actin filament system.

  • 15568.
    Aspenström, Pontus
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    Ruusala, Aino
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    Pacholsky, Dirk
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases2007In: Experimental Cell Research, ISSN 0014-4827, E-ISSN 1090-2422, Vol. 313, no 17, p. 3673-3679Article, review/survey (Refereed)
    Abstract [en]

    The Rho GTPases are influential regulators of signalling pathways that control vital cellular processes such as cytoskeletal dynamics, gene transcription, cell cycle progression and cell transformation. A vast majority of the studies involving Rho GTPases have been focused to the famous triad, Cdc42, Rac1 and RhoA, but this protein family actually harbours 20 members. Recently, the less known Rho GTPases have received increased attention. Many of the less studied Rho GTPases have structural, as well as, functional features which makes it pertinent to classify them as atypical Rho GTPases. This review article will focus on the critical aspects of the atypical Rho GTPases, RhoH, Wrch-1, Chp and RhoBTB. These proteins are involved in a broad spectre of biological processes, such as cytoskeletal dynamics, T-cell signalling and protein ubiquitinylation. We will also discuss the roles of atypical Rho GTPases as oncogenes or tumour suppressors, as well as their potential involvement in human diseases.

  • 15569.
    Aspenström-Fagerlund, Bitte
    et al.
    Toxicology Division, National Food Administration, P.O. Box 622, SE-75126 Uppsala, Sweden.
    Ring, Linda
    Toxicology Division, National Food Administration, P.O. Box 622, SE-75126 Uppsala, Sweden.
    Aspenström, Pontus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
    Tallkvist, Jonas
    Department of Pathology, Pharmacology and Toxicology, Swedish University of Agricultural Sciences, Box 7028, SE-75007, Uppsala, Sweden.
    Ilbäck, Nils-Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Glynn, Anders W.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology, Environmental Toxicology.
    Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes2007In: Toxicology, ISSN 0300-483X, E-ISSN 1879-3185, Vol. 237, no 1-3, p. 12-23Article in journal (Refereed)
    Abstract [en]

    Surface active compounds present in food possibly have the ability to enhance the absorption of water soluble toxic agents. Therefore, we investigated whether fatty acids such as oleic acid and docosahexaenoic acid (DHA), both commonly present in food, negatively affect the integrity of tight junctions (TJ) in the intestinal epithelium and thereby increase the absorption of poorly absorbed hydrophilic substances. Caco-2 cells, which are derived from human absorptive enterocytes, were grown on permeable filters for 20-25 days. Differentiated cell monolayers were apically exposed for 90min to mannitol in emulsions of oleic acid (5, 15 or 30mM) or DHA (5, 15 or 30mM) in an experimental medium with or without Ca(2+) and Mg(2+). Absorption of (14)C-mannitol increased and trans-epithelial electrical resistance (TEER) decreased in cell monolayers exposed to oleic acid and DHA, compared to controls. Cytotoxicity, measured as leakage of LDH, was higher in groups exposed to 30mM oleic acid and all concentrations of DHA. Morphology of the cell monolayers was studied by using fluorescence microscopy. Exposure of cell monolayers to 5mM DHA for 90min resulted in a profound alteration of the cell-cell contacts as detected by staining the cells for beta-catenin. Oleic acid (30mM) treatment also induced dissolution of the cell-cell contacts but the effect was not as pronounced as with DHA. Cell monolayers were also exposed for 180min to 250nM cadmium (Cd) in emulsions of oleic acid (5 or 30mM) or DHA (1 or 5mM), in an experimental medium with Ca(2+) and Mg(2+). Retention of Cd in Caco-2 cells was higher after exposure to 5mM oleic acid but lower after exposure to 30mM oleic acid and DHA. Absorption of Cd through the monolayers increased after DHA exposure but not after exposure to oleic acid. Our results indicate that fatty acids may compromise the integrity of the intestinal epithelium and that certain lipids in food may enhance the paracellular absorption of poorly absorbed hydrophilic substances.

  • 15570. Aspenström-Fagerlund, Bitte
    et al.
    Sundström, Birgitta
    Tallkvist, Jonas
    Ilbäck, Nils-Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Glynn, Anders W.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology, Environmental Toxicology.
    Fatty acids increase paracellular absorption of aluminium across Caco-2 cell monolayers2009In: Chemico-Biological Interactions, ISSN 0009-2797, E-ISSN 1872-7786, Vol. 181, no 2, p. 272-278Article in journal (Refereed)
    Abstract [en]

    Passive paracellular absorption, regulated by tight junctions (TJs), is the main route for absorption of poorly absorbed hydrophilic substances. Surface active substances, such as fatty acids, may enhance absorption of these substances by affecting the integrity of TJ and increasing the permeability. It has been suggested that aluminium (Al) absorption occurs mainly by the paracellular route. Herein, we investigated if physiologically relevant exposures of fully differentiated Caco-2 cell monolayers to oleic acid and docosahexaenoic acid (DHA), which are fatty acids common in food, increase absorption of Al and the paracellular marker mannitol. In an Al toxicity test, mannitol and Al absorption through Caco-2 cell monolayers were similarly modulated by Al concentrations between 1 and 30mM, suggesting that absorption of the two compounds occurred via the same pathways. Exposure of Caco-2 cell monolayers to non-toxic concentrations of Al (2mM) and (14)C-mannitol in fatty acid emulsions (15 and 30mM oleic acid, 5 and 10mM DHA) caused a decreased transepithelial electrical resistance (TEER). Concomitantly, fractional absorption of Al and mannitol, expressed as percentage of apical Al and mannitol retrieved at the basolateral side, increased with increasing dose of fatty acids. Transmission electron microscopy was applied to assess the effect of oleic acid on the morphology of TJ. It was shown that oleic acid caused a less structured morphology of TJ in Caco-2 cell monolayers. Taken together our findings indicate that fatty acids common in food increase the paracellular intestinal absorption of Al. These findings may influence future risk assessment of human Al exposure.

  • 15571. Aspenström-Fagerlund, Bitte
    et al.
    Tallkvist, Jonas
    Ilbäck, Nils-Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Glynn, Anders W.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Oleic acid decreases BCRP mediated efflux of mitoxantrone in Caco-2 cell monolayers2012In: Food and Chemical Toxicology, ISSN 0278-6915, E-ISSN 1873-6351, Vol. 50, no 10, p. 3635-3645Article in journal (Refereed)
    Abstract [en]

    Breast cancer resistance protein (BCRP) efflux restricts intestinal absorption of substances like heterocyclic amines, mycotoxins and certain human and veterinary drugs. Fat rich meals seem to increase absorption of drugs which are BCRP substrates or inhibitors. We therefore hypothesize that absorption of toxicants normally effluxed by BCRP are increased by fatty acids in food. Transport across and accumulation of H-3-Mitoxantrone (MXR) in Caco-2 cell monolayers were measured after 60 min exposure to emulsions of H-3-MXR (1 mu M) and oleic acid (0.5-5 mM). In addition, BCRP gene expression (RT-PCR) and the amount of BCRP protein (Western blot) were measured in oleic acid exposed Caco-2 cells. Oleic acid increased transport of MXR in a concentration dependent manner and 2 mM oleic acid or higher increased accumulation of MXR in cells, without any signs of cytotoxicity. Gene expression of BCRP was increased after exposure to oleic acid for 6 h, but the amount of BCRP protein was not increased. In conclusion, oleic acid clearly induced BCRP gene expression and reduced BCRP mediated efflux, although the amount of BCRP in cells was not affected. Consequently, effects of fatty acids on BCRP mediated efflux are important to consider in risk assessment of toxicants in food.

  • 15572.
    Asper, M.
    et al.
    Charles River Biopharmaceut Serv GmbH, D-51105 Cologne, Germany..
    Hanrieder, T.
    Charles River Biopharmaceut Serv GmbH, D-51105 Cologne, Germany..
    Quellmalz, Arne
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Mihranyan, Albert
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Removal of xenotropic murine leukemia virus by nanocellulose based filter paper2015In: Biologicals (Print), ISSN 1045-1056, E-ISSN 1095-8320, Vol. 43, no 6, p. 452-456Article in journal (Refereed)
    Abstract [en]

    The removal of xenotrpic murine leukemia virus (xMuLV) by size-exclusion filter paper composed of 100% naturally derived cellulose was validated. The filter paper was produced using cellulose nanofibers derived from Cladophora sp. algae. The filter paper was characterized using atomic force microscopy, scanning electron microscopy, helium pycnometry, and model tracer (100 nm latex beads and 50 nm gold nanoparticles) retention tests. Following the filtration of xMuLV spiked solutions, LRV >= 5.25 log(10) TCID50 was observed, as limited by the virus titre in the feed solution and sensitivity of the tissue infectivity test. The results of the validation study suggest that the nanocellulose filter paper is useful for removal of endogenous rodent retroviruses and retrovirus-like particles during the production of recombinant proteins.

  • 15573.
    Asperholm Hedlund, Laura
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    The discrepancy between the decreased support for women as political leaders and the increased percentage of women in parliament in post-coup d’état Madagascar2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 15574.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    A Conversation with Gernot Grabher2008Other (Other (popular science, discussion, etc.))
  • 15575.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    A Note on Global Capitalism2008In: Global Capitalism, The Road Ahead, 2008, p. 3-16Chapter in book (Other academic)
  • 15576.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Aesthetic Markets2008Conference paper (Other (popular science, discussion, etc.))
  • 15577.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Alfred Marshall and the Concept of Class2010In: The American journal of economics and sociology, ISSN 0002-9246, E-ISSN 1536-7150, Vol. 69, no 1, p. 151-165Article in journal (Refereed)
    Abstract [en]

    The purpose of this article is to analyze Alfred Marshall's concept of class. Marshall's concept of class is not well-studied. His idea of class is different from what Weber and Marx have proposed. In contrast to many other economists, he has a discussion of class that is developed. It is shown that Marshall sees classes as made up of people whose work offers similar chances of developing their higher faculties. An integrated idea is that different class positions are associated with different discount rates of future outcomes. Marshall's class theory combines physical and mental components.

  • 15578.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Analyzing Order: Social Structure and Value in the Economic Sphere2008In: International Review of Sociology/Revue Internationale de Sociologie, Vol. 18, no 2, p. 301-316Article in journal (Refereed)
  • 15579.
    Aspers, Patrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Att tänka sociologi: föredrag den 16/3 2012 vid Sociologidagarna i Stockholm2012In: Sociologisk forskning, ISSN 0038-0342, Vol. 49, no 2, p. 145-160Article in journal (Other academic)
  • 15580.
    Aspers, Patrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Comment on ‘The Complex Market: Communications of Exchange, ObservingCompetitors, and Prices’ by Pascal Goeke and Evelyn Moser2018In: Sociologica, International Journal for Sociological Debate, ISSN 1971-8853, Vol. 12, no 1, p. 101-104Article in journal (Refereed)
  • 15581.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Configurations2007Conference paper (Refereed)
  • 15582.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Convaluations2008Other (Other academic)
    Abstract [en]

    This paper presents convaluation as a form of social coordination. A Convaluation is a partial social order that is based on evaluation in which identities are formed. Order refers to the predictability of the world, and identity of humans to the question of who one is. Convaluation is a more general form of social coordination than markets, and it is argued that convaluation should be seen in relation to the two other basic forms, hierarchy and network. Convaluations capture how evaluations play a central role in identity formation processes. Convaluations are constituted by value, social structure, culture and identities. The paper presents six forms of convaluations that can be used for understanding empirical cases. The paper also makes two interrelated contributions. The first is the discussion of formation of identities in processes of evaluation, and the second is the idea of the partial order of convaluations.

  • 15583.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Do Economists Make Markets? On the Performativity of Economics2008In: ACTA Sociologica, Vol. 51, no 2, p. 169-170Article, book review (Other (popular science, discussion, etc.))
  • 15584.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Economic Sociology2011In: Encyclopedia of Consumer Culture / [ed] Southerton, Dale, USA: Sage Publications , 2011Chapter in book (Refereed)
  • 15585.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Economic Sociology2011In: Encyclopedia of Consumer Culture / [ed] Southerton, Dale, London: Sage , 2011Chapter in book (Refereed)
  • 15586.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Etnografiska Metoder2007Book (Other academic)
  • 15587.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Fashion Photography2010In: Berg Encyclopedia of World Dress and Fashion : The Fashion industry in West Europe Vol. 8 West Europe, Part 3 / [ed] editor-in-Chief: Joanne B. Eicher, Oxford: Berg , 2010Chapter in book (Other academic)
  • 15588.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Fashion-ology2007In: AnnexArticle, book review (Other (popular science, discussion, etc.))
  • 15589.
    Aspers, Patrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Forms of uncertainty reduction: decision, valuation, and contest2018In: Theory and society, ISSN 0304-2421, E-ISSN 1573-7853, Vol. 47, no 2, p. 133-149Article in journal (Refereed)
    Abstract [en]

    Uncertainty is an intriguing aspect of social life. Uncertainty is epistemic,future-oriented, and implies that we can neither predict nor foresee what will happenwhen acting. In cases in which no institutionalized certainty about future states exists,or can be generated, judgment is needed. This article presents the forms by whichuncertainty is reduced as a result of judgments made about different alternatives in aprocess involving several actors. This type of uncertainty may exist, for example, aboutwhich artist is the best, which offer in the market is more valuable, which football teamis better than all the rest, or which research proposal will get a grant. The result ofdifferent forms of uncertainty reduction is increased certainty concerning alternatives inrelation to one another, such as good and bad, rank lists, scores, quality assessment, andBwinner and losers.^ Based on the result, uncertainty is reduced and action is facilitated.The forms are structural and comprise roles; may be legitimate in a smaller or largerdomain; and may exist in all spheres of life, as exemplified in sports competitions, inlabor markets, and in the ranking of universities. Three forms of uncertainty reductionbased on judgment are identified in this article: (1) decision, made by an authority; (2)valuation, by means of which order arises as a result of actors ascribing values; and (3)contest, by which an order is the result of direct struggle.

  • 15590.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Friedrich Nietzsche as a Sociologist2007Other (Other academic)
  • 15591.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Friedrich Nietzsche’s Sociology2007In: Sociological Forum, Vol. 22, no 4, p. 474-498Article in journal (Refereed)
  • 15592.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Heidegger als Soziolog2008Conference paper (Other (popular science, discussion, etc.))
  • 15593.
    Aspers, Patrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Heidegger and socio-ontology: A sociological reading2013In: Journal of Classical Sociology, ISSN 1468-795X, E-ISSN 1741-2897, Vol. 13, no 4, p. 487-508Article in journal (Refereed)
    Abstract [en]

    This paper uses the work and employs the tools of the German philosopher Martin Heideggerto attempt to improve sociology. Heidegger’s thinking is employed primarily to undo a paradoxof sociology. Sociology focuses on the social, but starts with the assumption of essentially nonsocialegos that somehow generate a social world. This ‘egologism’ has caused sociology tooccupy itself with a number of pseudo-problems. We argue that Heidegger develops what we calla ‘socio-ontological’ approach, which means that human beings are always already social and dwelloriginarily in a social world. To present this ‘social foundation for sociology’ is the contribution ofthis paper.

  • 15594.
    Aspers, Patrik
    Stockholms universitet, Stockholms centrum för forskning om offentlig sektor (SCORE).
    How are Markets Made?: Max-Planck Institut für Gesellschaftsforschung, Working Paper, 2/09.2009Other (Other (popular science, discussion, etc.))
  • 15595.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Identity and Control: How social formations emerge2010In: Acta Sociologica, ISSN 0001-6993, E-ISSN 1502-3869, Vol. 53, no 1, p. 81-94Article, book review (Other academic)
  • 15596.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Identity Economics, How Identies Shape our Identities, Work and Well-Being2010In: Economic Sociology, The European Electronic Newsletter, Vol. 11, no 3, p. 75-76Article, book review (Other academic)
  • 15597.
    Aspers, Patrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Interview with Patrik Aspers: "Since There Are So Many Theories, We Should Focus on Really Good Empirical Research Instead"2016In: Economic Sociology, ISSN 1726-3247, E-ISSN 1726-3247, Vol. 17, no 5, p. 147-158Article in journal (Other academic)
    Abstract [en]

    Patrik Aspers is professor of sociology at Uppsala University (Uppsala Universitet). Maya Shmidt conducted this interview in Uppsala, Sweden, in September 2016. Aspers introduces readers to different academic paths by presenting his own experience of becoming a sociologist and comparing the structural and cultural differences between the American, British, and European academic contexts. During the conversation, Aspers discusses the field of economic sociology and highlights opportunities for interdisciplinary cooperation. Particularly, he notes that sociology has exported certain ideas to other disciplines, and due to the field's enduring tradition, extensive theoretical literature and ability to distinguish between and combine different research methods, there is no danger of "blurring" within cooperative efforts. Influenced by Harrison White's theory, Aspers develops a typology of different market forms. He argues that markets, when taken apart, do not look the same: they take different forms, and each requires its own construction of theoretical concepts that can account for the variety in the empirical reality. Aspers emphasizes the significance of clarifying and reflecting upon knowledge as elements of pre-study ("vorstudie") when it comes to qualitative research. He develops an empirical phenomenology method and presents it as a step-by-step procedure for conducting qualitative research.(1)

  • 15598.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Keith Hart Answers 11 Questions, Interview by P. Aspers2007In: Economic Sociology, European Electronic Newsletter, Vol. 9, no 1, p. 11-16Article in journal (Other (popular science, discussion, etc.))
  • 15599.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Knowledge and Valuation in Markets2009In: Theory and society, ISSN 0304-2421, E-ISSN 1573-7853, Vol. 39, no 2, p. 111-131Article in journal (Refereed)
  • 15600.
    Aspers, Patrik
    Stockholms universitet, Sociologiska institutionen.
    Labelling Fashion Markets2008In: International Journal of Consumer Studies, Vol. 32, p. 633-638Article in journal (Refereed)
309310311312313314315 15551 - 15600 of 252578
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