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  • 201.
    Söderman, Anne-Charlotte Hessén
    et al.
    Cityakuten, Dept Otorhinolaryngol, Olof Palmes Gata 9, S-11137 Stockholm, Sweden.;Karolinska Inst, Div Clin Sci Intervent & Technol, Stockholm, Sweden..
    Knutsson, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Vasteras Hosp, Dept Otorhinolaryngol, Vasteras, Sweden..
    Priwin, Claudia
    Karolinska Inst, Div Clin Sci Intervent & Technol, Stockholm, Sweden.;Queen Sophias Hosp, Dept Otorhinolaryngol, Stockholm, Sweden..
    von Unge, Magnus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Vasteras Hosp, Dept Otorhinolaryngol, Vasteras, Sweden.;Akershus Univ Hosp, Dept Otorhinolaryngol, Campus Ahus, Oslo, Norway.;Univ Oslo, Campus Ahus, Oslo, Norway..
    A randomized study of four different types of tympanostomy ventilation tubes - One-year follow-up2016Inngår i: International Journal of Pediatric Otorhinolaryngology, ISSN 0165-5876, E-ISSN 1872-8464, Vol. 89, s. 159-163Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To compare four different types of tympanostomy ventilation tubes (VT); long-shaft and short-shaft silicone tubes and long-shaft and short-shaft fluoroplastic tubes, regarding time to extrusion and events of otorrhea. Methods: A prospective randomized controlled trial in children with bilateral recurrent acute otitis media or secretory otitis media; four hundred children were randomized to receive one type of VT in the right ear and another type in the left ear. Postoperatively the children were assessed every third month by an otolaryngologist to monitor the incidence of otorrhea and tube extrusion. Results: Out of the 400 children, 22 were excluded during surgery. Mean age was 35.3 months. A majority (63.8%) were boys. Forty-eight children were lost to follow up during the first year. Significantly more short-shaft VTs were extruded after 12 months compared to long-shaft VTs, regardless of material. Significantly higher incidence of otorrhea was found in the fluoroplastic VT ears compared to the silicone ones, regardless of length of tube. Conclusion: Long-shaft VTs last longer in the eardrum during the first year of treatment. Silicone tubes render a reduced risk of otorrhea during the first year of treatment.

  • 202.
    Takumida, Masaya
    et al.
    Hiroshima Univ Hosp, Dept Otolaryngol, Hiroshima, Japan.
    Anniko, Matti
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear2019Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 139, nr 11, s. 948-952Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: In the inner ear, evidence has been gathered indicating that melatonin plays important roles in inner ear physiology and pathophysiology. However, no attempt has been made previously to investigate the localization or expression of melatonin and its receptors in the whole inner ear. Aims/objectives: To analyze the presence of melatonin and its receptors in the normal mouse inner ear. Material and methods: C57BL6/J mice were used in this study. The localizations of melatonin, MT1a and MT1b in the inner ear, i.e. cochlea, vestibular end organs, vestibular ganglion and endolymphatic sac (ES), were studied by immunohistochemistry. Results: The organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory cells, vestibular dark and transitional cells, and ES epithelial cells showed an immunofluorescence reaction to melatonin, MT1a and MT1b.

  • 203.
    Takumida, Masaya
    et al.
    Univ Hosp, Dept Otolaryngol, Hiroshima, Japan..
    Takumida, Hiroshi
    Univ Tokyo Hosp, Tokyo, Japan..
    Anniko, Matti
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Gastric-type H+,K+-ATPase in mouse vestibular end organs2017Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 137, nr 5, s. 455-459Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Conclusion: Gastric type H+,K+-ATPase in the vestibular end organs may be of importance for K+ circulation and may also be related to pH regulation in vestibular end organs and endolymphatic sac. Objective: To analyze the expression of gastric-type H+,K+-ATPase in normal mouse vestibular end organs. Methods: 8 weeks old CBA/J mice were used in this study. The presence of gastric-type H+,K+-ATPase alpha and beta in the vestibular end organs, viz. utricle, saccule, ampulla, vestibular ganglion, and endolymphatic sac, was investigated using immunohistochemistry. Results: In the vestibular end organs, H+,K+-ATPase alpha and beta were almost identical. H+,K+-ATPase was expressed in sensory cells, the basolateral surface of dark cells, fibrocytes, in vestibular ganglion cells, and in the upper region of the endolymphatic sac epithelial cells.

  • 204.
    Takumida, Masaya
    et al.
    Hiroshima Univ Hosp, Dept Otolaryngol, Hiroshima 7348551, Japan..
    Takumida, Hiroshi
    Univ Tokyo, Fac Med, Tokyo 1138654, Japan..
    Anniko, Matti
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Localization of histamine (H-1, H-2, H-3 and H-4) receptors in mouse inner ear2016Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 136, nr 6, s. 537-544Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Conclusion: The present findings show that all four types of histamine receptors (H1R, H2R, H3R, and H4R) are present in the inner ear, thus supporting the hypothesis that histamine plays a physiological role in the inner ear.

    Objective: To analyse the presence of histamine receptors in the normal mouse inner ear.

    Methods: CBA/J mice were used in this study. The localization of H1R, H2R, H3R, and H4R in the inner ear, i.e. cochlea, vestibular end organs, vestibular ganglion, and endolymphatic sac, was studied by real-time PCR and immunohistochemistry.

    Results: The mRNA for each receptor sub-type was detected in the inner ear. In the immunohistochemical study, the organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory epithelium, and endolymphatic sac cells showed an immunofluorescent reaction to all histamine receptors.

  • 205.
    Takumida, Masaya
    et al.
    Hiroshima Univ Hosp, Dept Otolaryngol, Hiroshima 7348551, Japan..
    Takumida, Hiroshi
    Univ Tokyo, Fac Med, Tokyo 1138654, Japan..
    Katagiri, Yoshiaki
    Hiroshima Univ Hosp, Dept Otolaryngol, Hiroshima 7348551, Japan..
    Anniko, Matti
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Localization of sirtuins (SIRT1-7) in the aged mouse inner ear2016Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 136, nr 2, s. 120-131Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Conclusion: The expression of sirtuin in vestibular end organs and cochlea responds differently to age-related changes. Down-regulation of SIRT1, 3, and 5 in the cochlea may weaken the protective activity regarding degeneration of the organ of Corti as well as of spiral ganglion cells, resulting in the development of age-related hearing loss. An increase in SIRT 1, 4, or 5 in vestibular tissue could indicate an increased need of detoxification of reactive oxygen species and an increased anti-ageing potential. Objective: To analyse the expression of sirtuins (SIRT1-7) in the normal young and old mouse inner ears. Methods: Young (8 weeks) and old (22 months) CBA/J mice were used in this study. Localization of SIRT1-7 in the inner ear, i.e. cochlea, vestibular end organs, and vestibular ganglion, was investigated using real-time PCR and immunohistochemistry. Results: In the vestibular end organs, the expression of SIRT1, 2, 4, 5 (both mRNA and protein), SIRT6, and 7 (only mRNA) was found to be increased, while a slightly decreased immunoreactivity was observed in SIRT3. In the cochlea, the expression of SIRT1, 3, and 5 (both mRNA and protein) was decreased in the old mice, whereas no noticeable difference was observed regarding SIRT2, 4, 6, or 7.

  • 206. Tallberg, Ing-Mari
    et al.
    Ivachova, Ekaterina
    Jones Tinghag, Karin
    Östberg, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Logopedi.
    Swedish norms for word fluency tests: FAS, animals and verbs2008Inngår i: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 49, nr 5, s. 479-485Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Verbal fluency tests are useful measures of acquired language impairment and cognitive decline of various etiologies. The aim of this study was to provide normative data for the Swedish population on the three verbal fluency tests, FAS, Animals and Verbs. A group of 165 healthy participants ranging from 16 to 89 years of age were assessed with the verbal fluency tests and tests of level of intellectual functioning. The sample was stratified by education, age and gender. Level of education had a substantial influence on the performance on verbal fluency, most clearly so in FAS and Verbs. Intellectual level had a positive and significant correlation with all measures of word fluency. Moreover, there was an interaction between age and gender such that women aged between 30 and 64 years outperformed elderly men on FAS and Verbs. Guidelines for instructions and scoring in Swedish are given in the article.

  • 207.
    Tideström Löfstrand, Britta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.
    Sleep Disordered Breathing and Orofacial Morphology in Relation to Adenotonsillar Surgery: Development from 4-12 Years in a Community Based Cohort2009Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Objective: To follow a cohort of children from age 4-6-12 with respect to sleep disordered breathing (SDB) and orofacial development. Questionnaires were completed about sleep, snoring, apneas, enuresis, sucking habits, and adenotonsillar surgery and, from age 12, about allergies, asthma, and general health. Children snoring regularly had an ENT- examinations including sleep studies (at ages 4 and 12) and an orthodontic evaluation. Development of biometric data in snoring children and not snoring controls was studied in relation to adenotonsillar surgery.

    Result: Of the original group of 615 children, 509 (83%) participated at age 6 and 393 (64%) at age 12. 27 snored regularly and 231 did not snore at age 12. Differences between groups were seen on all answers. From age 4–12 the prevalence of OSA decreased from 3.1% to 0.8%, and the minimum prevalence of snoring regularly from 5.3% to 4.2%. The odds for a child who snored regularly at four or six to be snoring regularly at age 12 was 3.7 times greater than for a not snoring child in spite of surgery (OR 3.7, 95% CI 2.4-5.7). 63 children were operated for snoring by age 12, of them 14 never snored and 17 snored regularly at age 12. Cross-bite was more common among snoring children at ages 4, 6 and 12 as was a narrower maxilla. In most cases, surgery cured the snoring temporarily, but the maxillar width was still smaller by age 12—even when nasal breathing was attained.

    Children snoring regularly at age 12, operated or not operated, showed long face anatomy and were oral breathers; the seven cases who were not operated and the five who were still snoring in spite of surgery, did not have reduced maxillary arch width.

    Conclusion: The prevalence of children snoring regularly is about the same from age four to twelve in a cohort where adenotonsillar surgery has been performed on obstructed cases, but the prevalence of OSA decreases considerably. The children snoring regularly have a more narrow maxilla compared to children not snoring—a condition that is not changed by adenotonsillar surgery regardless of symptom relief.

    Delarbeid
    1. The development of snoring and sleep related breathing distress from 4 to 6 years in a cohort of Swedish children
    Åpne denne publikasjonen i ny fane eller vindu >>The development of snoring and sleep related breathing distress from 4 to 6 years in a cohort of Swedish children
    2007 (engelsk)Inngår i: International Journal of Pediatric Otorhinolaryngology, ISSN 0165-5876, E-ISSN 1872-8464, Vol. 71, nr 7, s. 1025-1033Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    BACKGROUND: Snoring is common among both children and adults and a sign of sleep disordered breathing (SDB). Adenotonsillectomy is often the solution offered, although the effect is uncertain. There are also some who say that young children who snore will outgrow it even without treatment. The present investigation compares snoring and co-founding symptoms in parental reports for a cohort of children at age 4 and at age 6 years. METHOD: A cohort of 4 year old chidren (615) was investigated with respect to SDB [B. Löfstrand-Tideström, B. Thilander, J. Ahlqvist-Rastad, O. Jakobsson, E. Hultcrantz, Breathing obstruction in relation to craniofacial and dental arch morphology in 4 year old children, Eur. J. Orthod. 21 (1999) 323-332]. Each child was given a questionnaire. Those reporting significant symptoms also received a clinical and an orthodontic examination. Forty-eight children were diagnosed with SDB; of these 28 were operated with adenoidectomy and/or tonsillectomy. After 2 years, the same questionnaire was administered and the same children as before were further examined as well as those newly reporting significant symptoms. The results from the two occasions were compared. RESULTS: Eighty-three percent (509) of the original cohort participated. The frequency of snoring had changed from 53 to 46% for the group as a whole (p<0.05). Significant gender differences in co-founding symptoms were seen. Severity of snoring had changed on an individual basis in half of the cases; some recovered, others got worse. Of the children with SDB at 4 years who were operated, 14/28, did not snore at all, compared to 3/18 of the non-operated (p<0.05). CONCLUSION: Children who snore at the age 4 seldom "grow out of it" by age 6 and still show other signs of sleep related distress as well. Surgery does not always cure the snoring, thus postoperative follow-up is important. Since new cases develop during this age period, early intervention is not enough.

    Emneord
    snoring, children, epidemiology
    HSV kategori
    Identifikatorer
    urn:nbn:se:uu:diva-107990 (URN)10.1016/j.ijporl.2007.03.005 (DOI)17482278 (PubMedID)
    Tilgjengelig fra: 2009-09-02 Laget: 2009-09-02 Sist oppdatert: 2017-12-13bibliografisk kontrollert
    2. Development of craniofacial and dental arch morphology in relation to sleep  disordered breathing from 4 to 12 years: Effects of adenotonsillar surgery
    Åpne denne publikasjonen i ny fane eller vindu >>Development of craniofacial and dental arch morphology in relation to sleep  disordered breathing from 4 to 12 years: Effects of adenotonsillar surgery
    2010 (engelsk)Inngår i: International Journal of Pediatric Otorhinolaryngology, ISSN 0165-5876, E-ISSN 1872-8464, Vol. 74, nr 2, s. 137-143Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    OBJECTIVES: To study the development of craniofacial and dental arch morphology in children with sleep disordered breathing in relation to adenotonsillar surgery. SUBJECTS AND METHODS: From a community-based cohort of 644 children, 393 answered questionnaires at age 4, 6 and 12 years. Out of this group, 25 children who were snoring regularly at age 4 could be followed up to age 12 together with 24 controls not snoring at age 4, 6 and 12 years. Study casts were obtained from cases and controls and lateral cephalograms from the cases. Analysis regarding facial features and dento-alveolar development was performed. RESULTS: Children snoring regularly at age 4 showed reduced transversal width of the maxilla and more frequently had anterior open bite and lateral cross-bite than the controls. These conditions persisted for most cases at age 6, by which time 18/25 had been operated for snoring. In most of the cases, surgery cured the snoring temporarily, but their width of the maxilla was still smaller by age 12-even when nasal breathing was attained. At age 12, the frequency of lateral cross-bite was much reduced and anterior open bite was resolved, both in cases and controls. The children who snored regularly at age 12 operated or not operated, showed a long face anatomy and were oral breathers (this applied even to those who were operated). The seven cases who were not operated and the five who were still snoring in spite of surgery at age 12, did not have reduced maxillary width as compared to the controls. CONCLUSION: Dento-facial development in snoring children is not changed by adenotonsillar surgery regardless of symptom relief. If snoring persists or relapses orthodontic maxillar widening and/or functional training should be considered. Collaboration between otorhinolaryngologist, orthodontists and speech and language pathologists is strongly recommended.

    Emneord
    snoring, sleep disordered breathing, dental arch morphology, surgery, adenoectomy, tonsillectomy, development
    HSV kategori
    Identifikatorer
    urn:nbn:se:uu:diva-107999 (URN)10.1016/j.ijporl.2009.10.025 (DOI)000274598500004 ()19939470 (PubMedID)
    Tilgjengelig fra: 2009-09-03 Laget: 2009-09-03 Sist oppdatert: 2017-12-13bibliografisk kontrollert
    3. Breathing obstruction in relation to craniofacial and dental arch morphology in 4-year-old children
    Åpne denne publikasjonen i ny fane eller vindu >>Breathing obstruction in relation to craniofacial and dental arch morphology in 4-year-old children
    Vise andre…
    1999 (engelsk)Inngår i: European Journal of Orthodontics, ISSN 0141-5387, E-ISSN 1460-2210, Vol. 21, nr 4, s. 323-332Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    The prevalence of breathing obstruction was determined in a cohort of 4-year-old children. Craniofacial morphology was studied in obstructed children and compared with data from a control group of 4-year-old children with ideal occlusion. Dental arch morphology was compared in obstructed and non-obstructed children in the group. Parents of 95.5 per cent of the study base of 644 children answered a questionnaire concerning their child's nocturnal behaviour and related questions. The 48 children who, based on parental report, snored every night or stopped breathing when snoring (the 'snoring group'), showed a higher rate of disturbed sleep, mouth-breathing, and a history of throat infections as compared with the rest of the cohort. These children were examined by both an orthodontist and an otorhinolaryngologist and, when indicated, they were also monitored in a sleep laboratory. Twenty-eight of the children were diagnosed as having a breathing obstruction (4.3 per cent of the cohort) and six children (0.9 per cent) had sleep apnoea (mean apnoea-hypopnoea index of 17.3), using the same definition as that for adults. Cephalometric values among the obstructed children differed from those of a Swedish sample of the same age with ideal occlusion. Thy had a smaller cranial base angle and a lower ratio of posterior/anterior total face height. Small, but not significant differences were seen for NSL-ML and NL-ML. Compared with 48 asymptomatic children from the same cohort, the obstructed children had a narrower maxilla, a deeper palatal height, and a shorter lower dental arch. In addition, the prevalence of lateral crossbite was significantly higher among the obstructed children.

    HSV kategori
    Identifikatorer
    urn:nbn:se:uu:diva-107989 (URN)10502895 (PubMedID)
    Tilgjengelig fra: 2009-09-02 Laget: 2009-09-02 Sist oppdatert: 2017-12-13bibliografisk kontrollert
  • 208.
    Uhlén, Inger
    et al.
    Karolinska University Hospital and Karolinska Institutet (CLINTEC), Stockholm, Sweden.
    Engström, Elisabeth
    Karolinska University Hospital and Karolinska Institutet (CLINTEC), Stockholm, Sweden.
    Kallioinen, Petter
    Stockholm University, Stockholm, Sweden.
    Nakeva von Mentzer, Cecilia
    Linköping University, Linköping, Sweden.
    Lyxell, Björn
    Linköping University, Linköping, Sweden.
    Sahlén, Birgitta
    Lund University, Lund, Sweden; Skåne University Hospital, Lund, Sweden.
    Lindgren, Magnus
    Lund University, Lund, Sweden.
    Using a multi-feature paradigm to measure mismatch responsesto minimal sound contrasts in children with cochlear implantsand hearing aids2017Inngår i: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 58, nr 5, s. 409-421Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Our aim was to explore whether a multi-feature paradigm (Optimum-1) for eliciting mismatch negativity (MMN) would objectively capture difficulties in perceiving small sound contrasts in children with hearing impairment (HI) listening through their hearing aids (HAs) and/or cochlear implants (CIs). Children aged 5-7 years with HAs, CIs and children with normal hearing (NH) were tested in a free-field setting using a multi-feature paradigm with deviations in pitch, intensity, gap, duration, and location. There were significant mismatch responses across all subjects that were positive (p-MMR) for the gap and pitch deviants (F(1,43) = 5.17, p = 0.028 and F(1,43) = 6.56, p = 0.014, respectively) and negative (MMN) for the duration deviant (F(1,43) = 4.74, p = 0.035). Only the intensity deviant showed a significant group interaction with MMN in the HA group and p-MMR in the CI group (F(2,43) = 3.40, p = 0.043). The p-MMR correlated negatively with age, with the strongest correlation in the NH subjects. In the CI group, the late discriminative negativity (LDN) was replaced by a late positivity with a significant group interaction for the location deviant. Children with severe HI can be assessed through their hearing device with a fast multi-feature paradigm. For further studies a multi-feature paradigm including more complex speech sounds may better capture variation in auditory processing in these children.

  • 209. V, Konya
    et al.
    P, Czarnewski
    M, Forkel
    A, Rao
    E, Kokkinou
    EJ, Villablanca
    S, Almer
    U, Lindforss
    Friberg, Danielle
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    C, Höög
    P, Bergman
    J, Mjösberg
    Vitamin D downregulates the IL-23 receptor pathway in human mucosal group 3 innate lymphoid cells.2018Inngår i: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 141, nr 1, s. 279-292Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    Vitamin D deficiency is a risk factor for inflammatory bowel disease (IBD). The IL-23–driven tissue-resident group 3 innate lymphoid cells (ILC3s) play essential roles in intestinal immunity, and targeting IL-23/12 is a promising approach in IBD therapy.

    Objective

    We set out to define the role of 1α,25-dihydroxy vitamin D3 (1,25D) in regulating functional responses of human mucosal ILC3s to IL-23 plus IL-1β stimulation.

    Methods

    Transcriptomes of sorted tonsillar ILC3s were assessed by using microarray analysis. ILC3 cytokine production, proliferation, and differentiation were determined by means of flow cytometry, ELISA, and multiplex immunoassay. Intestinal cell suspensions and ILC3s sorted from gut biopsy specimens of patients with IBD were also analyzed along with plasma 25-hydroxy vitamin D3 (25D) detection.

    Results

    ILC3s stimulated with IL-23 plus IL-1β upregulated the vitamin D receptor and responded to 1,25D with downregulation of the IL-23 receptor pathway. Consequently, 1,25D suppressed IL-22, IL-17F, and GM-CSF production from tonsillar and gut ILC3s. In parallel, 1,25D upregulated genes linked to the IL-1β signaling pathway, as well as the IL-1β–inducible cytokines IL-6, IL-8, and macrophage inflammatory protein 1α/β. The 1,25D-triggered skewing in ILC3 function was not accompanied or caused by changes in viability, proliferation, or phenotype. Finally, we confirmed low 25D plasma levels in patients with IBD with active inflammation.

    Conclusion

    In light of the beneficial targeting of IL-23/12 in patients with IBD, 1,25D appears as an interesting therapeutic agent that inhibits the IL-23 receptor pathway, providing a novel mechanism for how ILC3s could be manipulated to regulate intestinal inflammation.

  • 210.
    Wandin, Helena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Logopedi.
    KomRett: Utvärdering av en kommunikationskurs för närstående tillpersoner med Rett syndrom2010Independent thesis Advanced level (degree of Master (One Year)), 20 poäng / 30 hpOppgave
    Abstract [sv]

    I denna pilotstudie utvärderas KomRett, en kommunikationskurs för närstående till personer med Rett syndrom som genomfördes för första gången hösten 2009. Målsättningarna med KomRett var att öka kursdeltagarnas kunskap om kommunikation och strategier för att stimulera kommunikation samt grafisk AKK med eller utan ljud. Kursen utformades med utgångspunkt från innehållet i föräldrakurserna i projektet AKKTIV vid DART Center i Göteborg (Alternativ och Kompletterande Kommunikation Tidig InterVention till föräldrar som har barn med kommunikationssvårigheter). Kommunikationspartners till fyra personer med Rett syndrom deltog i studien. I utvärderingen användes analys av olika skattningsformulär samt videoanalys av filmer från två kursdeltagare. Resultaten visar att tre av sex kursdeltagarna började använda bilder i sin kommunikation med personerna med Rett syndrom efter kursen. I videoanalysen framkom att en av två kursdeltagare oftare använde en responsiv kommunikationsstil i vald aktivitet efter kursen. Höga poäng på utvärderingsformuläret tydde på att kursdeltagarna uppfattade kursen positivt och flera av kursdeltagarna uppgav att de var mer uppmärksamma på kommunikationen efter kursen.

  • 211.
    Wang, Allen Y.
    et al.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Sir Charles Gairdner Hosp, Dept Otolaryngol Head & Neck, Skull Base Surg, Perth, WA, Australia..
    Liew, Lawrence J.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA, Australia.;Ear Sci Inst Australia, Perth, WA, Australia..
    Shen, Yi
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Ningbo Lihuili Hosp, Ningbo Med Ctr, Dept Otolaryngol Head & Neck Surg, Ningbo, Zhejiang, Peoples R China..
    Wang, Jeffrey T.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA, Australia..
    von Unge, Magnus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Akershus Univ Hosp, Lorenskog, Norway.;Univ Oslo, N-0316 Oslo, Norway..
    Atlas, Marcus D.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Sir Charles Gairdner Hosp, Dept Otolaryngol Head & Neck, Skull Base Surg, Perth, WA, Australia..
    Dilley, Rodney J.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA, Australia.;Ear Sci Inst Australia, Perth, WA, Australia..
    Rat model of chronic tympanic membrane perforation: A longitudinal histological evaluation of underlying mechanisms2017Inngår i: International Journal of Pediatric Otorhinolaryngology, ISSN 0165-5876, E-ISSN 1872-8464, Vol. 93, s. 88-96Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To evaluate histologically the progressive development and underlying mechanisms of chronic tympanic membrane perforation (TMP) in a rat model using a two-weeks ventilation tube (VT) treatment combined with topical application of mitomycin Cidexamethasone (VT-MID), compared with normal tympanic membrane and acute TMPs. Methods: Fifty male Sprague-Dawley rats were divided into three experimental groups: a normal control group (n = 5), an acute TMP group (n = 5) (i.e. 3 days post-myringotomy) and a VT-M/D group (n = 40). The TMs were regularly assessed by otoscopy. The normal control animals were sacrificed on day 0 and the acute TMP group was sacrificed 3 days post-myringotomy for histological and immunohistochemical evaluations. The VT-M/D group was sacrificed at various time points - 14 and 17 days, 3, 4, 6, 8 and 10 weeks. Results: On longitudinal histological examination, compared with normal TM and acute TMP, the perforation edges at the later time points illustrated thickened stratified squamous epithelium rimming around the edges, significant increase in keratin and collagen deposition, increased macrophage infiltration as well as reduced cellular proliferation. Three phases of TMP healing process were identified the acute healing phase (3-17 days), the transition phase (3-4 weeks) and the chronic phase (6-10 weeks). Conclusion: Based on the histological results of this study, the progressive development of chronic TMPs appeared to be associated with increased epidermal thickening, collagen and keratin deposition, macrophage infiltration and reduced cellular proliferation. After the 3-4 weeks of transition phase, the TMPs seemed to have transformed into a non-healing chronic TMP between 6 and 10 weeks. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

  • 212.
    Wang, Allen Y.
    et al.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Sir Charles Gairdner Hosp, Dept Otolaryngol Head & Neck, Skull Base Surg, Perth, WA, Australia..
    Liew, Lawrence J.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA, Australia.;Ear Sci Inst Australia, Perth, WA, Australia..
    Shen, Yi
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Ningbo Lihuili Hosp, Ningbo Med Ctr, Dept Otolaryngol Head & Neck Surg, Ningbo, Zhejiang, Peoples R China..
    Wang, Jeffrey T.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA, Australia..
    von Unge, Magnus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Akershus Univ Hosp, Oslo, Norway.;Univ Oslo, Oslo, Norway.
    Dilley, Rodney J.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA, Australia.;Ear Sci Inst Australia, Perth, WA, Australia..
    In response to the letter to the editor regarding: Rat model of chronic tympanic membrane perforation: Ventilation tube with mitomycin C and dexamethasone2017Inngår i: International Journal of Pediatric Otorhinolaryngology, ISSN 0165-5876, E-ISSN 1872-8464, Vol. 100, s. 256-257Artikkel i tidsskrift (Annet vitenskapelig)
  • 213.
    Wang, Allen Y.
    et al.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Sir Charles Gairdner Hosp, Skull Base Surg, Dept Otolaryngol Head & Neck, Perth, WA, Australia..
    Shen, Yi
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Ningbo Lihuili Hosp, Ningbo Med Ctr, Dept Otolaryngol Head & Neck Surg, Ningbo, Zhejiang, Peoples R China..
    Liew, Lawrence J.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.;Ear Sci Inst Australia, Perth, WA, Australia..
    Wang, Jeffrey T.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia..
    von Unge, Magnus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Akershus Univ Hosp, Oslo, Norway.;Univ Oslo, N-0316 Oslo, Norway..
    Atlas, Marcus D.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.;Ear Sci Inst Australia, Perth, WA, Australia.;Sir Charles Gairdner Hosp, Skull Base Surg, Dept Otolaryngol Head & Neck, Perth, WA, Australia..
    Dilley, Rodney J.
    Univ Western Australia, Sch Surg, Ear Sci Ctr, Perth, WA 6009, Australia.;Ear Sci Inst Australia, Perth, WA, Australia..
    Rat model of chronic tympanic membrane perforation: Ventilation tube with mitomycin C and dexamethasone2016Inngår i: International Journal of Pediatric Otorhinolaryngology, ISSN 0165-5876, E-ISSN 1872-8464, Vol. 80, nr 1, s. 61-68Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: Chronic tympanic membrane perforation (TMP) in a clinical setting may attract surgical intervention. With the advent of modern biomaterials, new options are available for myringoplasty but safety and efficacy need evaluation in a chronic TMP animal model. The aim of this study was to evaluate the efficacy of ventilation tube (VT) insertion in conjunction with topical application of mitomycin Cl dexamethasone (M/D) for the creation of chronic TMP in rats. Methods: Thirty male Sprague-Dawley rats underwent myringotomy of the right tympanic membrane (TM) and were divided into three experimental groups: spontaneous healing (myringotomy control), VT insertion for 2 weeks and VT insertion for 2 weeks in conjunction with topical application of M/D (VT-M/D). All TMs were regularly assessed by otoscopy for 10 weeks and then animals were sacrificed for histological evaluation. Results: In the VT-M/D group, seven out of ten (70%) perforations were patent at 10 weeks (mean patency, 57.9 days; P < 0.01). The VT group had two out of ten (20%) perforations patent at 10 weeks (mean patency, 26.5 days; P < 0.01), while all TMPs from the myringotomy control group were closed by day 9 (mean patency, 7.2 days). Histologically, the TMPs patent at week 10 had a stratified squamous epithelialized rim, keratinocyte layer thickening around the perforation edge as well as increased collagen deposition and macrophage infiltration. Conclusion: Chronic TMP in a rat model was successfully created by VT insertion and the efficacy was increased in combination with topical application of M/D.

  • 214. Wang, Allen Y.
    et al.
    Shen, Yi
    Liew, Lawrence J.
    Wang, Jeffrey T.
    von Unge, Magnus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
    Atlas, Marcus D.
    Dilley, Rodney J.
    Searching for a rat model of chronic tympanic membrane perforation: Healing delayed by mitomycin C/dexamethasone but not paper implantation or iterative myringotomy2015Inngår i: International Journal of Pediatric Otorhinolaryngology, ISSN 0165-5876, E-ISSN 1872-8464, Vol. 79, nr 8, s. 1240-1247Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: Surgical intervention such as myringoplasty or tympanoplasty is an option in the current clinical management of chronic tympanic membrane perforation (TMP). Animal models of chronic TMP are needed for pre-clinical testing of new materials and to improve existing techniques. We evaluated several reported animal model techniques from the literature for the creation of chronic TMPs. The aim of this study was to evaluate production of chronic TMPs in a rat model using topical mitomycin C/dexamethasone, paper insertion into middle ear cavity (MEC) or re-myringotomy. Methods: Forty male Sprague-Dawley rats underwent myringotomy of the right tympanic membrane (TM) and were randomly divided into 3 experimental groups: application of topical mitomycin C/dexamethasone, paper insertion into middle ear cavity, or re-myringotomy. Control perforations were allowed to close spontaneously. TMs were assessed regularly with otoscopy for 8 weeks. At the end of 8 weeks, animals were sacrificed for histology. Results: The closure of TMPs was significantly delayed by mitomycin C/dexamethasone (mean patency, 18.9 days; P <= 0.01) compared with the control (mean patency, 7 days), but was not significantly delayed in the paper insertion group (mean patency, 9.4 days; P = 0.74). Repeated myringotomy of closed perforations (mean number of myringotomies, 8.9 per ear) stimulated acceleration of closure rather than delay. Histologically, the mitomycin C/dexamethasone group had almost normal TM morphology, while the paper insertion group revealed inflammatory and granulomatous responses. The re-myringotomy group had a thickened TM fibrous layer with collagen deposition. Conclusions: Mitomycin C/dexamethasone delayed TMP closure in rats but the effect was not sufficiently long-lasting to be defined as a chronic TMP. Neither paper insertion into middle ear cavity nor re-myringotomy created chronic TMP in rats. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

  • 215.
    Zhang, Xiaotong
    et al.
    Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 2, Dept Otolaryngol, Xian 710004, Shaanxi, Peoples R China..
    Xu, Xinda
    Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 2, Dept Otolaryngol, Xian 710004, Shaanxi, Peoples R China..
    Ma, Weijun
    Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 2, Dept Otolaryngol, Xian 710004, Shaanxi, Peoples R China..
    Zhang, Qing
    Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 2, Dept Otolaryngol, Xian 710004, Shaanxi, Peoples R China..
    Tong, Busheng
    Anhui Med Univ, Affiliated Hosp, Dept Otolaryngol Head & Neck, Hefei, Anhui, Peoples R China..
    Yu, Hong
    Jilin Univ, Hosp 1, Dept Otolaryngol Head & Neck Surg, Changchun 130021, Jilin, Peoples R China.;Karolinska Univ Hosp, Dept Neurotol & Audiol, S-17176 Stockholm, Sweden..
    Xu, Min
    Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 2, Dept Otolaryngol, Xian 710004, Shaanxi, Peoples R China..
    Ren, Tianying
    Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Dept Otolaryngol, Portland, OR 97239 USA.;Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Dept Head Neck Surg, Portland, OR 97239 USA..
    Rosenhall, Ulf
    Karolinska Inst, Karolinska Univ Hosp, Dept Clin Sci Intervent & Technol, S-17176 Stockholm, Sweden..
    Anniko, Matti
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Duan, Maoli
    Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 2, Dept Otolaryngol, Xian 710004, Shaanxi, Peoples R China.;Anhui Med Univ, Affiliated Hosp, Dept Otolaryngol Head & Neck, Hefei, Anhui, Peoples R China.;Karolinska Univ Hosp, Dept Neurotol & Audiol, S-17176 Stockholm, Sweden.;Karolinska Inst, Karolinska Univ Hosp, Dept Clin Sci Intervent & Technol, S-17176 Stockholm, Sweden..
    A clinical study of sudden deafness2015Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 135, nr 10, s. 1030-1035Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Conclusions: Sudden Sensorineural Hearing Loss (SSHL) was commonly seen in middle aged people. Tinnitus was reported by 87.2% of the patients, and dizziness or vertigo were reported by 48.5%. The most common concomitant disorder of SSHL was hyperlipidemia. Objective: A retrospective register study with SSHL was performed in Xi'an, China, from 2000-2009. Results: Of 617 inpatients, the right ear was affected in 267 cases, the left ears in 282 cases, and both ears in 68 cases. The most common age of patients was 41-50 years. There were 20.4% SSHL patients with hypertension, coronary artery disease, or diabetes, and 49.6% patients with hyperlipidemia. Auditory Brainstem Responses (ABR) were performed in 460 patients (504 ears) before treatment, and the ABR threshold of 56.4% ears was >90 dB. The constituent ratio of patients with an ABR threshold over 90 dB was greater in the vertigo group than the other group. CT and/or MRI scans were available in 277 cases, of which 40 cases (14.4%) were abnormal.

  • 216.
    Ölander, Christine
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Gudjonsson, Olafur
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Neurokirurgi.
    Kinnefors, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Laurell, Göran
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Edfeldt, Lennart
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Complications in translabyrinthine surgery of vestibular schwannoma2018Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 138, nr 7, s. 639-645Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To evaluate the risk of complications associated with tumor size and patient's age in translabyrinthine vestibular schwannoma surgery. Methods: 700 patients with vestibular schwannoma primarily underwent translabyrinthine surgery between 1988 and 2014. Pre- and postoperative data were collected in a database and incidence of the postoperative complications cerebrospinal fluid leakage, meningitis, intracranial hemorrhage (ICH), facial nerve function and mortality were assessed and related to the tumor size and patient's age and retrospectively evaluated. Results: The tumor size significantly influenced the incidence of ICH and facial nerve dysfunction whereas age was correlated to facial nerve outcome. Conclusions: The translabyrinthine approach is a safe surgical procedure with relatively low risks of complications. The tumor size was significantly associated with a higher risk of ICH and facial nerve dysfunction whereas age only influenced the facial nerve outcome.

  • 217.
    Östberg, Per
    et al.
    Karolinska Inst, Div Speech Language Pathol, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Speech Language Pathol, SE-14186 Stockholm, Sweden..
    Backlund, Charlotte
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
    Lindström, Emma
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
    Convergent and diagnostic validity of STAVUX, a word and pseudoword spelling test for adults2016Inngår i: Logopedics, Phoniatrics, Vocology, ISSN 1401-5439, E-ISSN 1651-2022, Vol. 41, nr 3, s. 124-128Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Few comprehensive spelling tests are available in Swedish, and none have been validated in adults with reading and writing disorders. The recently developed STAVUX test includes word and pseudoword spelling subtests with high internal consistency and adult norms stratified by education. This study evaluated the convergent and diagnostic validity of STAVUX in adults with dyslexia. Forty-six adults, 23 with dyslexia and 23 controls, took STAVUX together with a standard word-decoding test and a self-rated measure of spelling skills. STAVUX subtest scores showed moderate to strong correlations with word-decoding scores and predicted self-rated spelling skills. Word and pseudoword subtest scores both predicted dyslexia status. Receiver-operating characteristic (ROC) analysis showed excellent diagnostic discriminability. Sensitivity was 91% and specificity 96%. In conclusion, the results of this study support the convergent and diagnostic validity of STAVUX.

  • 218.
    Östberg, Per
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Logopedi.
    Fernaeus, Sven-Erik
    Bogdanovic, Nenad
    Wahlund, Lars-Olof
    Word sequence production in cognitive decline: forward ever, backward never2008Inngår i: Logopedics, Phoniatrics, Vocology, ISSN 1401-5439, E-ISSN 1651-2022, Vol. 33, nr 3, s. 126-135Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Backward recall of automatic word sequences involves declarative and working memory abilities known to be impaired in the early stages of cognitive decline. Yet its utility in the diagnosis of mild cognitive impairment and mild dementia has not been studied in detail. We analysed word sequence production in 234 participants drawn from three categories: subjective cognitive impairment, mild cognitive impairment, and mild dementia in Alzheimer's disease. The names of the months were used as a diagnostic target for investigating forward versus backward sequence production. Forward production remained normal across categories. In contrast, backward speed was significantly decreased in mild cognitive impairment. In dementia both speed and accuracy were impaired. Backward production had significant diagnostic classificatory power. We conclude that word sequence production yields data relevant to the diagnosis of dementia with a minimum of time and expense.

  • 219.
    Östberg, Per
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Logopedi.
    Fernaeus, Sven-Erik
    Hellström, Åke
    Bogdanovic, Nenad
    Wahlund, Lars-Olof
    Impaired verb fluency: a sign of mild cognitive impairment2005Inngår i: Brain and Language, ISSN 0093-934X, E-ISSN 1090-2155, Vol. 95, nr 2, s. 273-279Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We assessed verb fluency vs. noun and letter-based fluency in 199 subjects referred for cognitive complaints including Subjective Cognitive Impairment, Mild Cognitive Impairment, and Alzheimer's disease. ANCOVAs and factor analyses identified verb, noun, and letter-based fluency as distinct tasks. Verb fluency performance in Mild Cognitive Impairment differed significantly from Subjective Cognitive Impairment and Alzheimer's disease. Reduced verb fluency thus appears to be a linguistic marker for incipient dementia. One possibility is that the verb fluency deficit in Mild Cognitive Impairment results from degenerative processes known to occur in the parahippocampal region.

2345 201 - 219 of 219
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