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  • 201.
    Johansson, Henrik
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysioterapi.
    Norlander, Katarina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Hedenström, Hans
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Nordang, Leif
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Nordvall, Lennart
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik.
    Emtner, Margareta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysioterapi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Exercise-induced dyspnea is a problem among the general adolescent population2014Inngår i: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 108, nr 6, s. 852-858Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Rationale: Respiratory symptoms during exercise are common and might limit adolescents' ability to take part in physical activity. Objective: To estimate the prevalence, determinants and consequences of exercise-induced dyspnea (EID) on daily life in a general population of 12-13 year old adolescents. Methods: A letter was sent to the parents of all 12-13 year old adolescents in the city of Uppsala (n = 3838). Parents were asked to complete a questionnaire together with their child on EID, asthma and allergy, consequences for daily life (wheeze, day time- and nocturnal dyspnea) and physical activity. The response rate was 60% (n = 2309). Results: Fourteen percent (n = 330) reported EID, i.e. had experienced an attack of shortness of breath that occurred after strenuous activity within the last 12 months. Female gender, ever-asthma and rhinitis were independently associated with an increased risk of EID. Ever-asthma was reported by 14.6% (n = 338), and 5.4% (n = 128) had both EID and ever-asthma. Sixty-one percent (n = 202) of the participants with EID did not have a diagnosis of asthma. In addition to rhinitis, participants with EID reported current wheeze and day-time as well as nocturnal dyspnea more often. than the group without EID. No difference was found in the level of physical activity between participants with and without EID. Conclusion: Adolescents with undiagnosed exercise-induced dyspnea have respiratory symptoms and are affected in daily life but have the same level of physical activity as adolescents without exercise-induced respiratory symptoms. 

  • 202.
    Johansson, Henrik
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysioterapi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Norlander, Katarina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Nordang, Leif
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Emtner, Margareta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysioterapi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
    The relationship between exercise induced bronchial obstruction and health related quality of life in female and male adolescents from a general population2016Inngår i: BMC Pulmonary Medicine, ISSN 1471-2466, E-ISSN 1471-2466, Vol. 16, artikkel-id 63Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    Background: Previous studies have observed that exercise-induced bronchoconstriction (EIB) is more common and more strongly related to exercise related breathing problems in female adolescents than male adolescents. However, few studies have investigated the association between EIB and health related quality of life (HRQoL) from a gender perspective. The aim of this study was to examine the association between EIB and HRQoL and physical activity level in female and male adolescents with and without EIB. Methods: From a population based study on exercise-induced breathing problems among adolescents (13-15 years, n = 3838) a cross sectional study with prospective data collection was carried out in a random subsample of 140 adolescents. The subjects in the sample were tested for EIB with a standardised exercise test, of which 49 adolescents were tested positive. HRQoL was assessed with the Pediatric Quality of Life Inventory (PedsQL) and the adolescents' physical activity levels were measured objectively with accelerometer. Results: The female subjects with EIB reported a lower HRQoL, both in total score (p = 0.03) and physical functioning score (p = 0.009) and had a lower baseline FEV1 compared to females without EIB (88 vs. 94 % predicted, p = 0.001). No differences were found in HRQoL or baseline lung function between males with or without EIB. There were no differences in minutes of moderate to vigorous physical activity per day between females or males with and without EIB. Conclusion: In a general population, the female adolescents with EIB had lower HRQoL and poorer baseline lung function compared to counterparts without EIB. These differences were not observed in males. EIB does not appear to affect the level of daily physical activity neither in females nor males.

  • 203.
    Johansson, Henrik
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Åsenlöf: Fysioterapi.
    Norlander, Katarina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Increased prevalence of exercise-induced airway symptoms: A five-year follow-up from adolescence to young adulthood2019Inngår i: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 154, s. 76-81Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Exercise-induced airway symptoms are common in adolescents. Little is known about the development of symptoms from adolescence to early adulthood. Therefore, we studied the prevalence, incidence, and remission of exercise-induced airway symptoms (including wheeze, cough, chest and throat tightness, hoarseness, and stridor) in adolescents, over a five-year period.

    Methods: In 2011, all adolescents aged 12-13 years in Uppsala (n=3 838) were invited to answer a questionnaire on exercise-induced airway symptoms. All responding adolescents (n=2 309) were invited to answer the same questionnaire again after five years. In total, 1 002 adolescents responded (43.4%).

    Results: The prevalence of exercise-induced airway symptoms increased from 25% at baseline to 49% at follow-up (p<0.001). More females than males reported symptoms at both time points. The incidence of airway symptoms was 42.2%, with no sex differences. More males than females reported symptom remission (20.2 vs. 10.7%, p<0.001). Females reported a higher asthma prevalence at follow-up than at baseline (7.6 vs. 15.2%), while males did not (10.9 vs. 8.0%), leading to a sex difference in prevalence at follow-up (p<0.001). Smoking and baseline respiratory symptoms were associated with an increased risk of reporting symptoms at follow-up.

    Conclusions: A twofold increase in the prevalence of exercise-induced airway symptoms over a five-year period was found in this cohort. Females were more likely to report symptoms at both time points. Knowledge of these age-related changes in symptoms and their association to female gender is useful for future studies and healthcare providers.

  • 204.
    Johansson, M. L.
    et al.
    Oticon Med AB, Askim, Sweden.;Univ Gothenburg, Dept Biomat, Inst Clin Sci, Sahlgrenska Acad, Gothenburg, Sweden..
    Stokroos, R. J.
    Maastricht Univ, Dept Otorhinolaryngol & Head & Neck Surg, Med Ctr, Maastricht, Netherlands..
    Banga, R.
    Queen Elizabeth Hosp, Birmingham, W Midlands, England..
    Hol, M. K.
    Radboud Univ Nijmegen, Dept Otorhinolaryngol, Med Ctr, Nijmegen, Netherlands..
    Mylanus, E. A.
    Radboud Univ Nijmegen, Dept Otorhinolaryngol, Med Ctr, Nijmegen, Netherlands..
    Jones, H. Savage
    Midland Reg Hosp, Tullamore, Ireland..
    Tysome, J. R.
    Cambridge Univ Teaching Hosp NHS Trust, Dept Skull Base Surg, Addenbrookes Hosp, Cambridge, England..
    Vannucchi, P.
    Univ Florence, Careggi Hosp, Dept Surg Sci & Translat Med, Unit Audiol, Florence, Italy..
    Hof, J. R.
    Maastricht Univ, Dept Otorhinolaryngol & Head & Neck Surg, Med Ctr, Maastricht, Netherlands..
    Brunings, J. W.
    Maastricht Univ, Dept Otorhinolaryngol & Head & Neck Surg, Med Ctr, Maastricht, Netherlands..
    van Tongeren, J.
    Maastricht Univ, Dept Otorhinolaryngol & Head & Neck Surg, Med Ctr, Maastricht, Netherlands..
    Lutgert, R. W.
    Isala Klin, Zwolle, Netherlands..
    Banerjee, A.
    James Cook Univ Hosp, Dept Otolaryngol, Middlesbrough, Cleveland, England..
    Windfuhr, J. P.
    Kliniken Maria Hilf, Dept Otolaryngol Head & Neck Surg, Monchengladbach, Germany..
    Caruso, A.
    Grp Otol, Piacenza, Italy..
    Giannuzzi, A. L.
    Grp Otol, Piacenza, Italy..
    Bordin, S.
    Venice Int Otolaryngol Network, Venice, Italy..
    Hanif, J.
    Norfolk & Norwich Univ Hosp NHS Trust, Norwich, Norfolk, England..
    Schart-Moren, Nadine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Singam, S.
    Torbay Hosp, Dept ENT & Audiol, Torquay, Devon, England..
    Jonhede, S.
    Oticon Med AB, Askim, Sweden..
    Holmberg, M.
    Oticon Med AB, Askim, Sweden..
    Cremers, C. W.
    Radboud Univ Nijmegen, Dept Otorhinolaryngol, Med Ctr, Nijmegen, Netherlands..
    Hultcrantz, M.
    Karolinska Univ Hosp, Dept Otorhinolaryngol, Stockholm, Sweden..
    Short-term results from seventy-six patients receiving a bone-anchored hearing implant installed with a novel minimally invasive surgery technique2017Inngår i: Clinical Otolaryngology, ISSN 1749-4478, E-ISSN 1365-2273, Vol. 42, nr 5, s. 1043-1048Artikkel i tidsskrift (Annet vitenskapelig)
  • 205.
    Johnson Chacko, Lejo
    et al.
    Med Univ Innsbruck, Dept Otolaryngol, Innsbruck, Austria..
    Pechriggl, Elisabeth J.
    Med Univ Innsbruck, Div Clin & Funct Anat, Dept Anat Histol & Embryol, Innsbruck, Austria..
    Fritsch, Helga
    Med Univ Innsbruck, Div Clin & Funct Anat, Dept Anat Histol & Embryol, Innsbruck, Austria..
    Rask-Andersen, Helge
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Blumer, Michael J. F.
    Med Univ Innsbruck, Div Clin & Funct Anat, Dept Anat Histol & Embryol, Innsbruck, Austria..
    Schrott-Fischer, Anneliese
    Med Univ Innsbruck, Dept Otolaryngol, Innsbruck, Austria..
    Glueckert, Rudolf
    Med Univ Innsbruck, Dept Otolaryngol, Innsbruck, Austria.;Tirol Kliniken, Univ Clin Innsbruck, Innsbruck, Austria..
    Neurosensory Differentiation and Innervation Patterning in the Human Fetal Vestibular End Organs between the Gestational Weeks 8-122016Inngår i: Frontiers in Neuroanatomy, ISSN 1662-5129, E-ISSN 1662-5129, Vol. 10, artikkel-id 111Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Balance orientation depends on the precise operation of the vestibular end organs and the vestibular ganglion neurons. Previous research on the assemblage of the neuronal network in the developing fetal vestibular organ has been limited to data from animal models. Insights into the molecular expression profiles and signaling moieties involved in embryological development of the human fetal inner ear have been limited. We present an investigation of the cells of the vestibular end organs with specific focus on the hair cell differentiation and innervation pattern using an uninterrupted series of unique specimens from gestational weeks 8-12. Nerve fibers positive for peripherin innervate the entire fetal crista and utricle. While in rodents only the peripheral regions of the cristae and the extra-striolar region of the statolithic organs are stained. At week 9, transcription factors PAX2 and PAX8 were observed in the hair cells whereas PAX6 was observed for the first time among the supporting cells of the cristae and the satellite glial cells of the vestibular ganglia. Glutamine synthetase, a regulator of the neurotransmitter glutamate, is strongly expressed among satellite glia cells, transitional zones of the utricle and supporting cells in the sensory epithelium. At gestational week 11, electron microscopic examination reveals bouton contacts at hair cells and first signs of the formation of a protocalyx at type I hair cells. Our study provides first-hand insight into the fetal development of the vestibular end organs as well as their pattern of innervation by means of immunohistochemical and EM techniques, with the aim of contributing toward our understanding of balance development.