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  • 239051.
    Woo, Hani
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    Engelskt inflytande i svenska och koreanska: En jämförande attitydundersökning2014Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Denna uppsats studerar attityd till engelskt inflytande i svenska hos svenskar respektive i koreanska hos koreaner samt sverigekoreaner. Syftet med uppsatsen är att ta reda på vilka medvetna och undermedvetna attityder svenskar och sydkoreaner har till inblandningen av engelska ord i svenska respektive koreanska. Uppsatsen syftar också till att utröna om och i så fall hur en annorlunda språkmiljö påverkar attityden till denna inblandning i koreanska hos sverigekoreaner. Studien utgår ifrån min observation av frekvent inblandning av engelska ord hos svenskar, vilket går emot min iakttagelse hos sydkoreaner som ofta visar irriterade reaktioner till inblandningen av engelska ord i koreanska. En bakgrundsfaktor är också att svenska och koreanska har olika historiska och språkpolitiska förhållanden.

    Studien bygger på tre olika undersökningar, vilka är matched guise-test, enkät och intervju, inkl. ett ordvalstest. De två första undersökningarna genomfördes med informanter bestående av svenskar resp. koreaner med avsikt att beskriva och jämföra undermedvetna och medvetna attityder. Med sverigekoreaner, indelade i tre grupper efter språkbakgrund, nämligen förstagenerations-, 1,5- och andragenerations- och övriga koreaner, utfördes en intervjuundersökning.

    Resultatet visar att det finns stora skillnader mellan medvetna och undermedvetna attityder till engelskt inflytande i svenska hos svenskar respektive i koreanska hos koreaner och att attityderna mellan länderna skiljer sig åt kraftigt. För Sveriges del visades det att man är mer negativ till engelskt inflytande i matched guise-testet än i enkäten medan det var tvärtom i Sydkorea. Förvånansvärt nog var sydkoreaner mycket positivare till engelskt inflytande i matched guise-testet och de hade en mer språkpatriotisk inställning i enkäten. Detta tyder på att språkpatriotism och attityd mot engelska inte alltid hänger ihop. Genom intervjuundersökningen kom det fram att attityderna till engelska och inblandningen av engelska ord varierar en del beroende på språkbakgrund och på att koreanska har en mycket stark ställning hos informanterna oavsett språkbakgrund. Däremot visades det att den positiva ställningen till koreanskan hos informanterna inte är särskilt märkbar när de använder språk i verkligheten. Resultatet av ordvalsfrågorna mellan ”renare” koreanska ord och engelska lånord i intervjuerna visade att informanternas val beror mest på grad av etablering i språket, ej själva språket. Enligt intervjuundersökningen verkar sverigekoreanernas attityd till inblandningen av engelska i koreanska inte ha påverkats av deras annorlunda, mer blandade språkmiljö.

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  • 239052.
    Woo, Hani
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    Inversion och satsadverbialsplacering i koreanska universitetsstudenters inlärarsvenska2013Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna uppsats belyser inlärning av inversion i påståendesatser och satsadverbialsplacering i svenska hos koreanska universitetsstudenter som läser svenska som främmande språk.

    Syftet med uppsatsen är att ta reda på om processbarhetsteorin också gäller inlärare i svenska som främmande språk i fråga om inversion i påståendesatser och satsadverbialsplacering.

    Studien bygger på analyser av åtta texter skrivna av koreanska studenter som gick kursen Intermediate Swedish Composition (2) vid Hankuk University of Foreign Studies i Sydkorea höstterminen 2012. Texterna har analyserat med fältscheman och provats på processbarhetsteorins utvecklingsfaser. I analysen har hänsyn tagits till hur väl inlärarna behärskar inversion i påståendesatser och placering av satsadverbial samt av några tidsadverbial (sådana som tenderar att placeras medialt i sats) i huvudsats och bisats.

    Resultatet visar att inlärarna i studien har hög behärskning av såväl inversion i påståendesatser som av satsadverbialsplacering och att det finns en viss skillnad på placeringen av olika typer av satsadverbial. Dessutom verkar det som om inlärarna använder sig av det tidigare tillägnade språket engelska i inlärning av inversionsregeln och satsadverbialsplacering i svenska. Kravet på inversion förefaller därtill vara tydligare för dem när en relativt lång bisats fundamenteras än när ett kort led gör det, vilket säger emot tidigare undersökningar. Det är svårt att dra någon tydlig slutsats från studien, eftersom materialet är litet och inlärarna tillämpar inversion i påståendesatser och satsadverbialsplcering väl, men inlärarna följer troligtvis processbarhetsteorins utvecklingsfaser i fråga om inversion och satsadverbialsplacering. 

  • 239053. Woo, Janet
    et al.
    Chiu, Gigi N. C.
    Karlsson, Göran
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Physical Chemistry.
    Wasan, Ellen
    Ickenstein, Ludger
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Physical Chemistry.
    Edwards, Katarina
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Physical Chemistry.
    Bally, Marcel B.
    Use of a passive equilibration methodology to encapsulate cisplatin into preformed thermosensitive liposomes2008In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 349, no 1-2, p. 38-46Article in journal (Refereed)
    Abstract [en]

    A conventional, cholesterol-containing liposome formulation of cisplatin has demonstrated insignificant activity in clinical trials, due in part, to insufficient release of encapsulated content following localization within solid tumors. For this reason, the development of a triggered release liposome formulation is desirable. In this report, cisplatin was encapsulated into lysolipid-containing thermosensitive liposomes (LTSL) using a novel technique, which relies on the equilibration of cisplatin across the liposomal membrane at temperatures above the gel-to-liquid crystalline phase transition temperature (T-C) of the bulk phospholipid. Mild heating and drug loading into LTSL did not induce morphological changes of the liposomes. In vitro data demonstrated that >95% of encapsulated cisplatin was released from LTSL within 5 min following mild heating at 42 degrees C, while <5% was released at 37 degrees C. Under similar conditions, lysolipid-free thermosensitive liposomes exhibited 70% release of cisplatin at 42 degrees C, and cholesterol-containing liposomes exhibited negligible drug release at 42 degrees C. The pharmacokinetic profiles of LTSL- and TSL-cisplatin indicated that these formulations were rapidly eliminated from circulation (terminal t(1/2) Of 1.09 and 2.83 h, respectively). The therapeutic utility of LTSL-cisplatin formulation will be based on strategies where hyperthermia is applied prior to the administration of the liposomal drug-a strategy similar to that used in the clinical assessment of LTSL-doxorubicin formulation.

  • 239054. Wood, A.
    et al.
    Beven, Keith J.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    On runoff generation and the distribution of storage deficits2013In: HYDROLOGY RESEARCH, ISSN 1998-9563, Vol. 44, no 4, p. 673-689Article in journal (Refereed)
    Abstract [en]

    A number of hydrological models use a distribution function to develop the non-linear rainfall-runoff catchment response. In this study the beta function is applied to represent a distribution of soil moisture storages in conjunction with a fast and slow pathway routing. The BETA3 and BETA4 modules, presented in this paper, have a distribution of discrete storage elements that have variable and redistributed water levels at each timestep. The PDM-BETA5 is an analytical solution with a similar structure to the commonly used probability distribution model (PDM). Model testing was performed on three catchments in the Northern Pennine region in England. The performances of the BETA models were compared with a commonly used formulation of the PDM. The BETA models performed marginally better than the PDM in calibration and parameter estimation was better with the BETA models than for the PDM. The BETA models had a small advantage in validation on the hydrologically fast responding test catchments.

  • 239055. Wood, Andrew R
    et al.
    Esko, Tonu
    Yang, Jian
    Vedantam, Sailaja
    Pers, Tune H
    Gustafsson, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Chu, Audrey Y
    Estrada, Karol
    Luan, Jian'an
    Kutalik, Zoltán
    Amin, Najaf
    Buchkovich, Martin L
    Croteau-Chonka, Damien C
    Day, Felix R
    Duan, Yanan
    Fall, Tove
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Fehrmann, Rudolf
    Ferreira, Teresa
    Jackson, Anne U
    Karjalainen, Juha
    Lo, Ken Sin
    Locke, Adam E
    Mägi, Reedik
    Mihailov, Evelin
    Porcu, Eleonora
    Randall, Joshua C
    Scherag, André
    Vinkhuyzen, Anna A E
    Westra, Harm-Jan
    Winkler, Thomas W
    Workalemahu, Tsegaselassie
    Zhao, Jing Hua
    Absher, Devin
    Albrecht, Eva
    Anderson, Denise
    Baron, Jeffrey
    Beekman, Marian
    Demirkan, Ayse
    Ehret, Georg B
    Feenstra, Bjarke
    Feitosa, Mary F
    Fischer, Krista
    Fraser, Ross M
    Goel, Anuj
    Gong, Jian
    Justice, Anne E
    Kanoni, Stavroula
    Kleber, Marcus E
    Kristiansson, Kati
    Lim, Unhee
    Lotay, Vaneet
    Lui, Julian C
    Mangino, Massimo
    Leach, Irene Mateo
    Medina-Gomez, Carolina
    Nalls, Michael A
    Nyholt, Dale R
    Palmer, Cameron D
    Pasko, Dorota
    Pechlivanis, Sonali
    Prokopenko, Inga
    Ried, Janina S
    Ripke, Stephan
    Shungin, Dmitry
    Stancáková, Alena
    Strawbridge, Rona J
    Sung, Yun Ju
    Tanaka, Toshiko
    Teumer, Alexander
    Trompet, Stella
    van der Laan, Sander W
    van Setten, Jessica
    Van Vliet-Ostaptchouk, Jana V
    Wang, Zhaoming
    Yengo, Loïc
    Zhang, Weihua
    Afzal, Uzma
    Arnlöv, Johan
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Arscott, Gillian M
    Bandinelli, Stefania
    Barrett, Amy
    Bellis, Claire
    Bennett, Amanda J
    Berne, Christian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Blüher, Matthias
    Bolton, Jennifer L
    Böttcher, Yvonne
    Boyd, Heather A
    Bruinenberg, Marcel
    Buckley, Brendan M
    Buyske, Steven
    Caspersen, Ida H
    Chines, Peter S
    Clarke, Robert
    Claudi-Boehm, Simone
    Cooper, Matthew
    Daw, E Warwick
    De Jong, Pim A
    Deelen, Joris
    Delgado, Graciela
    Denny, Josh C
    Dhonukshe-Rutten, Rosalie
    Dimitriou, Maria
    Doney, Alex S F
    Dörr, Marcus
    Eklund, Niina
    Eury, Elodie
    Folkersen, Lasse
    Garcia, Melissa E
    Geller, Frank
    Giedraitis, Vilmantas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Go, Alan S
    Grallert, Harald
    Grammer, Tanja B
    Gräßler, Jürgen
    Grönberg, Henrik
    de Groot, Lisette C P G M
    Groves, Christopher J
    Haessler, Jeffrey
    Hall, Per
    Haller, Toomas
    Hallmans, Goran
    Hannemann, Anke
    Hartman, Catharina A
    Hassinen, Maija
    Hayward, Caroline
    Heard-Costa, Nancy L
    Helmer, Quinta
    Hemani, Gibran
    Henders, Anjali K
    Hillege, Hans L
    Hlatky, Mark A
    Hoffmann, Wolfgang
    Hoffmann, Per
    Holmen, Oddgeir
    Houwing-Duistermaat, Jeanine J
    Illig, Thomas
    Isaacs, Aaron
    James, Alan L
    Jeff, Janina
    Johansen, Berit
    Johansson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Jolley, Jennifer
    Juliusdottir, Thorhildur
    Junttila, Juhani
    Kho, Abel N
    Kinnunen, Leena
    Klopp, Norman
    Kocher, Thomas
    Kratzer, Wolfgang
    Lichtner, Peter
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Lindström, Jaana
    Lobbens, Stéphane
    Lorentzon, Mattias
    Lu, Yingchang
    Lyssenko, Valeriya
    Magnusson, Patrik K E
    Mahajan, Anubha
    Maillard, Marc
    McArdle, Wendy L
    McKenzie, Colin A
    McLachlan, Stela
    McLaren, Paul J
    Menni, Cristina
    Merger, Sigrun
    Milani, Lili
    Moayyeri, Alireza
    Monda, Keri L
    Morken, Mario A
    Müller, Gabriele
    Müller-Nurasyid, Martina
    Musk, Arthur W
    Narisu, Narisu
    Nauck, Matthias
    Nolte, Ilja M
    Nöthen, Markus M
    Oozageer, Laticia
    Pilz, Stefan
    Rayner, Nigel W
    Renstrom, Frida
    Robertson, Neil R
    Rose, Lynda M
    Roussel, Ronan
    Sanna, Serena
    Scharnagl, Hubert
    Scholtens, Salome
    Schumacher, Fredrick R
    Schunkert, Heribert
    Scott, Robert A
    Sehmi, Joban
    Seufferlein, Thomas
    Shi, Jianxin
    Silventoinen, Karri
    Smit, Johannes H
    Smith, Albert Vernon
    Smolonska, Joanna
    Stanton, Alice V
    Stirrups, Kathleen
    Stott, David J
    Stringham, Heather M
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Swertz, Morris A
    Syvänen, Ann-Christine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Tayo, Bamidele O
    Thorleifsson, Gudmar
    Tyrer, Jonathan P
    van Dijk, Suzanne
    van Schoor, Natasja M
    van der Velde, Nathalie
    van Heemst, Diana
    van Oort, Floor V A
    Vermeulen, Sita H
    Verweij, Niek
    Vonk, Judith M
    Waite, Lindsay L
    Waldenberger, Melanie
    Wennauer, Roman
    Wilkens, Lynne R
    Willenborg, Christina
    Wilsgaard, Tom
    Wojczynski, Mary K
    Wong, Andrew
    Wright, Alan F
    Zhang, Qunyuan
    Arveiler, Dominique
    Bakker, Stephan J L
    Beilby, John
    Bergman, Richard N
    Bergmann, Sven
    Biffar, Reiner
    Blangero, John
    Boomsma, Dorret I
    Bornstein, Stefan R
    Bovet, Pascal
    Brambilla, Paolo
    Brown, Morris J
    Campbell, Harry
    Caulfield, Mark J
    Chakravarti, Aravinda
    Collins, Rory
    Collins, Francis S
    Crawford, Dana C
    Cupples, L Adrienne
    Danesh, John
    de Faire, Ulf
    den Ruijter, Hester M
    Erbel, Raimund
    Erdmann, Jeanette
    Eriksson, Johan G
    Farrall, Martin
    Ferrannini, Ele
    Ferrières, Jean
    Ford, Ian
    Forouhi, Nita G
    Forrester, Terrence
    Gansevoort, Ron T
    Gejman, Pablo V
    Gieger, Christian
    Golay, Alain
    Gottesman, Omri
    Gudnason, Vilmundur
    Gyllensten, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Haas, David W
    Hall, Alistair S
    Harris, Tamara B
    Hattersley, Andrew T
    Heath, Andrew C
    Hengstenberg, Christian
    Hicks, Andrew A
    Hindorff, Lucia A
    Hingorani, Aroon D
    Hofman, Albert
    Hovingh, G Kees
    Humphries, Steve E
    Hunt, Steven C
    Hypponen, Elina
    Jacobs, Kevin B
    Jarvelin, Marjo-Riitta
    Jousilahti, Pekka
    Jula, Antti M
    Kaprio, Jaakko
    Kastelein, John J P
    Kayser, Manfred
    Kee, Frank
    Keinanen-Kiukaanniemi, Sirkka M
    Kiemeney, Lambertus A
    Kooner, Jaspal S
    Kooperberg, Charles
    Koskinen, Seppo
    Kovacs, Peter
    Kraja, Aldi T
    Kumari, Meena
    Kuusisto, Johanna
    Lakka, Timo A
    Langenberg, Claudia
    Le Marchand, Loic
    Lehtimäki, Terho
    Lupoli, Sara
    Madden, Pamela A F
    Männistö, Satu
    Manunta, Paolo
    Marette, André
    Matise, Tara C
    McKnight, Barbara
    Meitinger, Thomas
    Moll, Frans L
    Montgomery, Grant W
    Morris, Andrew D
    Morris, Andrew P
    Murray, Jeffrey C
    Nelis, Mari
    Ohlsson, Claes
    Oldehinkel, Albertine J
    Ong, Ken K
    Ouwehand, Willem H
    Pasterkamp, Gerard
    Peters, Annette
    Pramstaller, Peter P
    Price, Jackie F
    Qi, Lu
    Raitakari, Olli T
    Rankinen, Tuomo
    Rao, D C
    Rice, Treva K
    Ritchie, Marylyn
    Rudan, Igor
    Salomaa, Veikko
    Samani, Nilesh J
    Saramies, Jouko
    Sarzynski, Mark A
    Schwarz, Peter E H
    Sebert, Sylvain
    Sever, Peter
    Shuldiner, Alan R
    Sinisalo, Juha
    Steinthorsdottir, Valgerdur
    Stolk, Ronald P
    Tardif, Jean-Claude
    Tönjes, Anke
    Tremblay, Angelo
    Tremoli, Elena
    Virtamo, Jarmo
    Vohl, Marie-Claude
    Amouyel, Philippe
    Asselbergs, Folkert W
    Assimes, Themistocles L
    Bochud, Murielle
    Boehm, Bernhard O
    Boerwinkle, Eric
    Bottinger, Erwin P
    Bouchard, Claude
    Cauchi, Stéphane
    Chambers, John C
    Chanock, Stephen J
    Cooper, Richard S
    de Bakker, Paul I W
    Dedoussis, George
    Ferrucci, Luigi
    Franks, Paul W
    Froguel, Philippe
    Groop, Leif C
    Haiman, Christopher A
    Hamsten, Anders
    Hayes, M Geoffrey
    Hui, Jennie
    Hunter, David J
    Hveem, Kristian
    Jukema, J Wouter
    Kaplan, Robert C
    Kivimaki, Mika
    Kuh, Diana
    Laakso, Markku
    Liu, Yongmei
    Martin, Nicholas G
    März, Winfried
    Melbye, Mads
    Moebus, Susanne
    Munroe, Patricia B
    Njølstad, Inger
    Oostra, Ben A
    Palmer, Colin N A
    Pedersen, Nancy L
    Perola, Markus
    Pérusse, Louis
    Peters, Ulrike
    Powell, Joseph E
    Power, Chris
    Quertermous, Thomas
    Rauramaa, Rainer
    Reinmaa, Eva
    Ridker, Paul M
    Rivadeneira, Fernando
    Rotter, Jerome I
    Saaristo, Timo E
    Saleheen, Danish
    Schlessinger, David
    Slagboom, P Eline
    Snieder, Harold
    Spector, Tim D
    Strauch, Konstantin
    Stumvoll, Michael
    Tuomilehto, Jaakko
    Uusitupa, Matti
    van der Harst, Pim
    Völzke, Henry
    Walker, Mark
    Wareham, Nicholas J
    Watkins, Hugh
    Wichmann, H-Erich
    Wilson, James F
    Zanen, Pieter
    Deloukas, Panos
    Heid, Iris M
    Lindgren, Cecilia M
    Mohlke, Karen L
    Speliotes, Elizabeth K
    Thorsteinsdottir, Unnur
    Barroso, Inês
    Fox, Caroline S
    North, Kari E
    Strachan, David P
    Beckmann, Jacques S
    Berndt, Sonja I
    Boehnke, Michael
    Borecki, Ingrid B
    McCarthy, Mark I
    Metspalu, Andres
    Stefansson, Kari
    Uitterlinden, André G
    van Duijn, Cornelia M
    Franke, Lude
    Willer, Cristen J
    Price, Alkes L
    Lettre, Guillaume
    Loos, Ruth J F
    Weedon, Michael N
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    O'Connell, Jeffrey R
    Abecasis, Goncalo R
    Chasman, Daniel I
    Goddard, Michael E
    Visscher, Peter M
    Hirschhorn, Joel N
    Frayling, Timothy M
    Defining the role of common variation in the genomic and biological architecture of adult human height2014In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 46, no 11, p. 1173-1186Article in journal (Refereed)
    Abstract [en]

    Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

  • 239056.
    Wood, Angela M.
    et al.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Kaptoge, Stephen
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Butterworth, Adam S.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Willeit, Peter
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.;Med Univ Innsbruck, Innsbruck, Austria..
    Warnakula, Samantha
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Bolton, Thomas
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Paige, Ellie
    Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia..
    Paul, Dirk S.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Sweeting, Michael
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Burgess, Stephen
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.;Univ Cambridge, Cambridge Inst Publ Hlth, MRC Biostat Unit, Cambridge, England..
    Bell, Steven
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Astle, William
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Stevens, David
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Koulman, Albert
    Univ Cambridge, NIHR BRC Nutr Biomarker Lab, Cambridge, England..
    Selmer, Randi M.
    Norwegian Inst Publ Hlth, Oslo, Norway..
    Verschuren, W. M. Monique
    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands.;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands..
    Sato, Shinichi
    Chiba Prefectural Inst Publ Hlth, Chiba, Japan..
    Njolstad, Inger
    Univ Tromso, Dept Community Med, Tromso, Norway..
    Woodward, Mark
    Univ Oxford, Nuffield Dept Populat Hlth, Med Sci Div, Oxford, England.;Univ Sydney, George Inst Global Hlth, Sydney, NSW, Australia.;Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA..
    Salomaa, Veikko
    THL Natl Inst Hlth & Welf, Helsinki, Finland..
    Nordestgaard, Borge G.
    Copenhagen Univ Hosp, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark..
    Yeap, Bu B.
    Univ Western Australia, Sch Med, Perth, WA, Australia.;Fiona Stanley Hosp, Perth, WA, Australia.;Harry Perkins Inst Med Res, Perth, WA, Australia..
    Fletcher, Astrid
    London Sch Hyg & Trop Med, London, England..
    Melander, Olle
    Lund Univ, Dept Clin Sci, Malmo, Sweden..
    Kuller, Lewis H.
    Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA..
    Balkau, Beverley
    INSERM, UMRS 1018, CESP, Villejuif, France..
    Marmot, Michael
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Koenig, Wolfgang
    Tech Univ Munich, Deutsch Herzzentrum Munchen 92, DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.;Univ Ulm, Med Ctr, Ulm, Germany..
    Casiglia, Edoardo
    Univ Padua, Dept Med, Padua, Italy..
    Cooper, Cyrus
    Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England..
    Arndt, Volker
    German Canc Res Ctr, Heidelberg, Germany..
    Franco, Oscar H.
    Erasmus Univ, Med Ctr, Rotterdam, Netherlands..
    Wennberg, Patrik
    Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden..
    Gallacher, John
    Cardiff Univ, Dept Primary Care & Publ Hlth, Cardiff, S Glam, Wales..
    de la Camara, Agustin Gomez
    CIBERESP, Octubre Res Inst 12, Madrid, Spain..
    Volzke, Henry
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany..
    Dahm, Christina C.
    Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark..
    Dale, Caroline E.
    UCL, UCL Inst Hlth Informat, Farr Inst Hlth Informat Res, London, England..
    Bergmann, Manuela M.
    German Inst Human Nutr, Potsdam, Germany..
    Crespo, Carlos J.
    Portland State Univ, Sch Community Hlth, Portland, OR 97207 USA..
    van der Schouw, Yvonne T.
    Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands..
    Kaaks, Rudolf
    German Canc Res Ctr, Heidelberg, Germany..
    Simons, Leon A.
    Univ New South Wales, St Vincents Clin Sch, Sydney, NSW, Australia..
    Lagiou, Pagona
    Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Athens, Greece.;Harvard TH Chan Sch Publ Hlth, Boston, MA USA..
    Schoufour, Josje D.
    Erasmus Univ, Med Ctr, Rotterdam, Netherlands..
    Boer, Jolanda M. A.
    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands..
    Key, Timothy J.
    Univ Oxford, Nuffield Dept Populat Hlth, Med Sci Div, Oxford, England..
    Rodriguez, Beatriz
    Univ Hawaii, Off Publ Hlth Studies, Honolulu, HI 96822 USA..
    Moreno-Iribas, Conchi
    Navarra Inst Hlth Res, IdiSNA, Inst Salud Publ Navarra, Pamplona, Spain.;Red Invest Serv Salud Enfermedades Cronicas REDIS, Pamplona, Spain..
    Davidson, Karina W.
    Columbia Univ Irving, Med Ctr, New York, NY USA..
    Taylor, James O.
    East Boston Neighborhood Hlth Ctr, Boston, MA USA..
    Sacerdote, Carlotta
    Citta Salute Sci Torino Hosp, Turin, Italy..
    Wallace, Robert B.
    Univ Iowa, Coll Publ Hlth, Iowa City, IA USA..
    Quiros, J. Ramon
    Consejeria Sanidad Principado Asturias, Oviedo, Asturias, Spain..
    Tumino, Rosario
    ASP, Civic M Arezzo Hosp, Ragusa, Italy..
    Blazer, Dan G., II
    Duke Univ, Duke Div Sch, Durham, NC USA..
    Linneberg, Allan
    Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark..
    Daimon, Makoto
    Hirosaki Univ, Dept Endocrinol & Metab, Hirosaki, Aomori, Japan..
    Panico, Salvatore
    Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy..
    Howard, Barbara
    Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA..
    Skeie, Guri
    UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway..
    Strandberg, Timo
    Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland..
    Weiderpass, Elisabete
    UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.;Canc Registry Norway, Inst Population Based Canc Res, Oslo, Norway.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Univ Helsinki, Epidemiol Grp, Folkhalsan Res Ctr, Fac Med, Helsinki, Finland..
    Nietert, Paul J.
    Univ South Carolina, Med, Charleston, SC USA..
    Psaty, Bruce M.
    Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98195 USA.;Univ Washington, Cardiovasc Hlth Res Unit, Dept Epidemiol, Seattle, WA 98195 USA.;Univ Washington, Cardiovasc Hlth Res Unit, Dept Hlth Serv, Seattle, WA 98195 USA.;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA..
    Kromhout, Daan
    Wageningen Univ, Dept Agrotechnol & Food Sci, Wageningen, Netherlands.;Univ Groningen, Fac Med Sci, Groningen, Netherlands.;Yale Univ, Sch Med, New Haven, CT USA..
    Salamanca-Fernandez, Elena
    Univ Granada, Hospit Univ Granada, Inst Invest Biosanitaria ibs GRANADA, Escuela Andaluza Salud Publ, Granada, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain..
    Kiechl, Stefan
    Med Univ Innsbruck, Innsbruck, Austria..
    Krumholz, Harlan M.
    Grioni, Sara
    Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy..
    Palli, Domenico
    Canc Res & Prevent Inst ISPO, Florence, Italy..
    Huerta, Jose M.
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.;IMIB Arrixaca, Murcia Reg Hlth Council, Murcia, Spain..
    Price, Jackie
    Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland..
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Arriola, Larraitz
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.;Basque Govt, Inst Biodonostia, San Sebastian, Spain..
    Arima, Hisatomi
    Univ Sydney, Sydney, NSW, Australia.;Royal Prince Alfred Hosp, Sydney, NSW, Australia.;Kyushu Univ, Dept Prevent Med & Publ Hlth, Fukuoka, Japan..
    Travis, Ruth C.
    Univ Oxford, Nuffield Dept Populat Hlth, Med Sci Div, Oxford, England..
    Panagiotakos, Demosthenes B.
    Harokopio Univ, Sch Hlth Sci & Educ, Athens, Greece..
    Karakatsani, Anna
    Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Athens, Greece..
    Trichopoulou, Antonia
    Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Athens, Greece..
    Kuhn, Tilman
    German Canc Res Ctr, Heidelberg, Germany..
    Grobbee, Diederick E.
    Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands..
    Barrett-Connor, Elizabeth
    Univ Calif San Diego, Dept Family Med & Publ Hlth, San Diego, CA 92103 USA..
    van Schoor, Natasja
    Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands..
    Boeing, Heiner
    German Inst Human Nutr, Potsdam, Germany..
    Overvad, Kim
    Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.;Aalborg Univ Hosp, Aalborg, Denmark..
    Kauhanen, Jussi
    Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland..
    Wareham, Nick
    Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England..
    Langenberg, Claudia
    Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England..
    Forouhi, Nita
    Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England..
    Wennberg, Maria
    Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden..
    Despres, Jean-Pierre
    Laval Univ, Dept Kinesiol, Quebec City, PQ, Canada..
    Cushman, Mary
    Univ Vermont, Dept Med, Burlington, VT USA..
    Cooper, Jackie A.
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Rodriguez, Carlos J.
    Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA.;Wake Forest Baptist Med Ctr, Winston Salem, NC USA..
    Sakurai, Masaru
    Kanazawa Med Univ, Dept Social & Environm Med, Kanazawa, Ishikawa, Japan..
    Shaw, Jonathan E.
    Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia..
    Knuiman, Matthew
    Populat Med Res Inst, Busselton, WA, Australia.;Univ Western Australia, Sch Populat & Global Hlth, Perth, WA, Australia..
    Voortman, Trudy
    Erasmus Univ, Med Ctr, Rotterdam, Netherlands..
    Meisinger, Christa
    Helmholtz Zentrum Munchen German Res Ctr Environm, Munich, Germany..
    Tjonneland, Anne
    Danish Canc Soc Res Ctr, Copenhagen, Denmark..
    Brenner, Hermann
    German Canc Res Ctr, Heidelberg, Germany.;Heidelberg Univ, Div Clin Epidemiol & Aging Res, Heidelberg, Germany..
    Palmieri, Luigi
    Ist Supe Sanita, Rome, Italy..
    Dallongeville, Jean
    Inst Pasteur, Lille, France..
    Brunner, Eric J.
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Assmann, Gerd
    Assmann Stiftung Pravent, Munster, Germany..
    Trevisan, Maurizio
    CUNY City Coll, New York, NY USA..
    Gillum, Richard F.
    Howard Univ Hosp, Washington, DC USA..
    Ford, Ian
    Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland..
    Sattar, Naveed
    Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland..
    Lazo, Mariana
    Johns Hopkins Univ, Sch Med, Baltimore, MD USA..
    Thompson, Simon G.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Ferrari, Pietro
    Int Agcy Res Canc, Lyon, France..
    Leon, David A.
    London Sch Hyg & Trop Med, London, England..
    Smith, George Davey
    Univ Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England..
    Peto, Richard
    Jackson, Rod
    Univ Auckland, Sch Populat Hlth, Auckland, New Zealand..
    Banks, Emily
    Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia..
    Di Angelantonio, Emanuele
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Danesh, John
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies2018In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 391, no 10129, p. 1513-1523Article in journal (Refereed)
    Abstract [en]

    Background: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease.

    Methods: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank). We characterised dose-response associations and calculated hazard ratios (HRs) per 100 g per week of alcohol (12.5 units per week) across 83 prospective studies, adjusting at least for study or centre, age, sex, smoking, and diabetes. To be eligible for the analysis, participants had to have information recorded about their alcohol consumption amount and status (ie, non-drinker vs current drinker), plus age, sex, history of diabetes and smoking status, at least 1 year of follow-up after baseline, and no baseline history of cardiovascular disease. The main analyses focused on current drinkers, whose baseline alcohol consumption was categorised into eight predefined groups according to the amount in grams consumed per week. We assessed alcohol consumption in relation to all-cause mortality, total cardiovascular disease, and several cardiovascular disease subtypes. We corrected HRs for estimated long-term variability in alcohol consumption using 152 640 serial alcohol assessments obtained some years apart (median interval 5.6 years [5th-95th percentile 1.04-13.5]) from 71 011 participants from 37 studies.

    Findings: In the 599 912 current drinkers included in the analysis, we recorded 40 310 deaths and 39 018 incident cardiovascular disease events during 5.4 million person-years of follow-up. For all-cause mortality, we recorded a positive and curvilinear association with the level of alcohol consumption, with the minimum mortality risk around or below 100 g per week. Alcohol consumption was roughly linearly associated with a higher risk of stroke (HR per 100 g per week higher consumption 1.14, 95% CI, 1.10-1.17), coronary disease excluding myocardial infarction (1.06, 1.00-1.11), heart failure (1.09, 1.03-1.15), fatal hypertensive disease (1.24, 1.15-1.33); and fatal aortic aneurysm (1.15, 1.03-1.28). By contrast, increased alcohol consumption was loglinearly associated with a lower risk of myocardial infarction (HR 0.94, 0.91-0.97). In comparison to those who reported drinking >0-<= 100 g per week, those who reported drinking >100-<= 200 g per week, >200-<= 350 g per week, or >350 g per week had lower life expectancy at age 40 years of approximately 6 months, 1-2 years, or 4-5 years, respectively.

    Interpretation: In current drinkers of alcohol in high-income countries, the threshold for lowest risk of all-cause mortality was about 100 g/week. For cardiovascular disease subtypes other than myocardial infarction, there were no clear risk thresholds below which lower alcohol consumption stopped being associated with lower disease risk. These data support limits for alcohol consumption that are lower than those recommended in most current guidelines.

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  • 239057.
    Wood, Christian M.
    et al.
    School of Physiology, Pharmacology and Neuroscience, University of Bristol..
    Nicolas, Celine S.
    School of Physiology, Pharmacology and Neuroscience, University of Bristol.
    Choi, Sun-Lim
    School of Physiology, Pharmacology and Neuroscience, University of Bristol.
    Roman, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Nylander, Ingrid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Fernandez-Teruel, Alberto
    Department of Psychiatry and Forensic Medicine, Institute of Neurosciences, Autonomous University of Barcelona.
    Kiianmaa, Kalervo
    Department of Alcohol, Drugs and Addiction, National Institute for Health and Welfare, POB 30 00271 Helsinki.
    Bienkowski, Przemyslaw
    Department of Pharmacology, Institute of Psychiatry and Neurology, Warsaw..
    de Jong, Trynke R.
    Department of Behavioural and Molecular Neuroendocrinology, University of Regensburg.
    Colombo, Giancarlo
    Neuroscience Institute, Section of Cagliari, National Research Council of Italy.
    Chastagnier, Denis
    Janvier Labs, CS4105 Le Genest-Saint-Isle.
    Wafford, Keith A
    Eli Lilly Research Laboratories, Windlesham.
    Collingridge, Graham L.
    School of Physiology, Pharmacology and Neuroscience, University of Bristol.
    Wildt, Sheryl J
    Envigo, 8520 Allison Pointe Boulevard, Indianapolis IN 46250.
    Conway-Campbell, Becky L
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building.
    Robinson, Emma S.J.
    School of Physiology, Pharmacology and Neuroscience, University of Bristol.
    Lodge, David
    School of Physiology, Pharmacology and Neuroscience, University of Bristol.
    Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour.2017In: Neuropharmacology, ISSN 0028-3908, E-ISSN 1873-7064, Vol. 115, p. 128-138Article, review/survey (Refereed)
    Abstract [en]

    Modulation of metabotropic glutamate 2 (mGlu2) receptor function has huge potential for treating psychiatric and neurological diseases. Development of drugs acting on mGlu2 receptors depends on the development and use of translatable animal models of disease. We report here a stop codon mutation at cysteine 407 in Grm2 (cys407*) that is common in some Wistar rats. Therefore, researchers in this field need to be aware of strains with this mutation. Our genotypic survey found widespread prevalence of the mutation in commercial Wistar strains, particularly those known as Han Wistar. Such Han Wistar rats are ideal for research into the separate roles of mGlu2 and mGlu3 receptors in CNS function. Previous investigations, unknowingly using such mGlu2 receptor-lacking rats, provide insights into the role of mGlu2 receptors in behaviour. The Grm2 mutant rats, which dominate some selectively bred lines, display characteristics of altered emotionality, impulsivity and risk-related behaviours and increased voluntary alcohol intake compared with their mGlu2 receptor-competent counterparts. In addition, the data further emphasize the potential therapeutic role of mGlu2 receptors in psychiatric and neurological disease, and indicate novel methods of studying the role of mGlu2 and mGlu3 receptors.

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  • 239058.
    Wood, Christopher J.
    et al.
    Univ Nottingham, Sch Chem, Univ Pk, Nottingham NG7 2RD, England..
    Summers, Gareth H.
    Univ Nottingham, Sch Chem, Univ Pk, Nottingham NG7 2RD, England..
    Clark, Charlotte A.
    Univ Nottingham, Sch Chem, Univ Pk, Nottingham NG7 2RD, England..
    Kaeffer, Nicolas
    Univ Grenoble Alpes, CNRS, Lab Chim & Biol Metaux, CEA, 17 Rue Martyrs, F-38000 Grenoble, France..
    Braeutigam, Maximilian
    Inst Photon Technol IPHT Jena eV, Albert Einstein Str 9, D-07745 Jena, Germany.;Univ Jena, Inst Phys Chem, Helmholtzweg 4, D-07743 Jena, Germany.;Univ Jena, Abbe Ctr Photon, Helmholtzweg 4, D-07743 Jena, Germany..
    Carbone, Lea Roberta
    Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy..
    D'Amario, Luca
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Fan, Ke
    Royal Inst Technol KTH, Sch Chem Sci & Engn, S-10044 Stockholm, Sweden..
    Farre, Yoann
    Univ Nantes, Fac Sci & Tech, Chim & Interdisciplinar Synth Anal Modelisat, CEISAM,CNRS,UMR 6230, 2 Rue Houssiniere,BP 92208, F-44322 Nantes 3, France..
    Narbey, Stephanie
    Solaronix, Rue Ouriette 129, CH-1170 Aubonne, Switzerland..
    Oswald, Frederic
    Solaronix, Rue Ouriette 129, CH-1170 Aubonne, Switzerland..
    Stevens, Lee A.
    Univ Nottingham, Div Mat Mech & Struct, Fac Engn, Univ Pk, Nottingham NG7 2RD, England..
    Parmenter, Christopher D. J.
    Univ Nottingham, Nottingham Nanotechnol & Nanosci Ctr, Univ Pk, Nottingham NG7 2RD, England..
    Fay, Michael W.
    Univ Nottingham, Nottingham Nanotechnol & Nanosci Ctr, Univ Pk, Nottingham NG7 2RD, England..
    La Torre, Alessandro
    Univ Nottingham, Nottingham Nanotechnol & Nanosci Ctr, Univ Pk, Nottingham NG7 2RD, England..
    Snape, Colin E.
    Univ Nottingham, Fac Engn, Dept Chem & Environm Engn, Univ Pk, Nottingham NG7 2RD, England..
    Dietzek, Benjamin
    Inst Photon Technol IPHT Jena eV, Albert Einstein Str 9, D-07745 Jena, Germany.;Univ Jena, Inst Phys Chem, Helmholtzweg 4, D-07743 Jena, Germany.;Univ Jena, Abbe Ctr Photon, Helmholtzweg 4, D-07743 Jena, Germany..
    Dini, Danilo
    Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy..
    Hammarström, Leif
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Pellegrin, Yann
    Univ Nantes, Fac Sci & Tech, Chim & Interdisciplinar Synth Anal Modelisat, CEISAM,CNRS,UMR 6230, 2 Rue Houssiniere,BP 92208, F-44322 Nantes 3, France..
    Odobel, Fabrice
    Univ Nantes, Fac Sci & Tech, Chim & Interdisciplinar Synth Anal Modelisat, CEISAM,CNRS,UMR 6230, 2 Rue Houssiniere,BP 92208, F-44322 Nantes 3, France..
    Sun, Licheng
    Royal Inst Technol KTH, Sch Chem Sci & Engn, S-10044 Stockholm, Sweden..
    Artero, Vincent
    Univ Grenoble Alpes, CNRS, Lab Chim & Biol Metaux, CEA, 17 Rue Martyrs, F-38000 Grenoble, France..
    Gibson, Elizabeth A.
    Univ Nottingham, Sch Chem, Univ Pk, Nottingham NG7 2RD, England.;Newcastle Univ, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England..
    A comprehensive comparison of dye-sensitized NiO photocathodes for solar energy conversion2016In: Physical Chemistry, Chemical Physics - PCCP, ISSN 1463-9076, E-ISSN 1463-9084, Vol. 18, no 16, p. 10727-10738Article in journal (Refereed)
    Abstract [en]

    We investigated a range of different mesoporous NiO electrodes prepared by different research groups and private firms in Europe to determine the parameters which influence good quality photoelectrochemical devices. This benchmarking study aims to solve some of the discrepancies in the literature regarding the performance of p-DSCs due to differences in the quality of the device fabrication. The information obtained will lay the foundation for future photocatalytic systems based on sensitized NiO so that new dyes and catalysts can be tested with a standardized material. The textural and electrochemical properties of the semiconducting material are key to the performance of photocathodes. We found that both commercial and non-commercial NiO gave promising solar cell and water-splitting devices. The NiO samples which had the two highest solar cell efficiency (0.145% and 0.089%) also gave the best overall theoretical H-2 conversion.

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  • 239059.
    Wood, CM
    et al.
    Uppsala University.
    Gilmour, KM
    Uppsala University.
    Part, P
    Uppsala University.
    Passive and active transport properties of a gill model, the cultured branchial epithelium of the freshwater rainbow trout (Oncorhynchus mykiss)1998In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY, ISSN 1095-6433, Vol. 119, no 1, p. 87-96Article in journal (Other scientific)
    Abstract [en]

    Branchial epithelia of freshwater rainbow trout. were cultured on permeable supports, polyethylene terephthalate membranes ("filter inserts"), starting from dispersed gill epithelial cells in primary culture. Leibowitz L-15 media plus foetal bovine serum

  • 239060.
    Wood, CM
    et al.
    Uppsala University.
    Part, P
    Uppsala University.
    Cultured branchial epithelia from freshwater fish gills1997In: JOURNAL OF EXPERIMENTAL BIOLOGY, ISSN 0022-0949, Vol. 200, no 6, p. 1047-1059Article in journal (Other scientific)
    Abstract [en]

    We have developed a method for the primary culture of gill epithelial cells from freshwater rainbow trout on permeable supports, polyethylene terephthalate membranes ('filter inserts'). Primary cultures of gill cells (6-9 days in Leibowitz L-15 culture me

  • 239061.
    Wood, David A.
    et al.
    Univ British Columbia, St Pauls & Vancouver Gen Hosp, Ctr Cardiovasc Innovat, 2775 Laurel St 9th Floor, Vancouver, BC V5Z 1M9, Canada.
    Cairns, John A.
    Univ British Columbia, St Pauls & Vancouver Gen Hosp, Ctr Cardiovasc Innovat, 2775 Laurel St 9th Floor, Vancouver, BC V5Z 1M9, Canada.
    Wang, Jia
    McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada.
    Mehran, Roxana
    Zena A Wiener Cardiovasc Inst, Icahn Sch Med Mt Sinai, New York, NY USA.
    Storey, Robert F.
    Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England.
    Nguyen, Helen
    McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada.
    Meeks, Brandi
    McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada.
    Kunadian, Vijay
    Newcastle Univ, Inst Cellular Med, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England;Newcastle Tyne Hosp NHS Fdn Trust, Cardiothorac Ctr, Freeman Hosp, Newcastle Upon Tyne, Tyne & Wear, England.
    Tanguay, Jean-Francois
    Montreal Heart Inst, Montreal, PQ, Canada;Univ Montreal, Montreal, PQ, Canada.
    Kim, Hahn-Ho
    St Marys Gen Hosp, Kitchener, ON, Canada.
    Cheema, Asim
    St Michaels Hosp, Toronto, ON, Canada.
    Deghani, Payam
    Univ Saskatchewan, Prairie Vasc Res Network, Regina, SK, Canada.
    Natarajan, Madhu K.
    McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada.
    Jolly, Sanjit S.
    McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada.
    Amerena, John
    Kardinia House, Geelong, Vic, Australia.
    Keltai, Matyas
    Hungarian Inst Cardiol, Budapest, Hungary.
    James, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Hlinomaz, Ota
    Univ Hosp St Anne, Brno, Czech Republic.
    Niemela, Kari
    Tampere Univ Hosp, Heart Ctr, Tampere, Finland.
    AlHabib, Khalid
    King Fahad Cardiac Ctr, Dept Cardiac Serv, Jeddah, Saudi Arabia.
    Lewis, Basil S.
    Lady Davis Carmel Med Ctr, Cardiovasc Clin Res Inst, Haifa, Israel.
    Nguyen, Michel
    Univ Sherbrooke, Ctr Hosp, Div Cardiol, Quebec City, PQ, Canada.
    Sarma, Jaydeep
    Wythenshawe Hosp, North West Heart Ctr, Manchester, Lancs, England.
    Dzavik, Vladimir
    Univ Hlth Network, Peter Munk Cardiac Ctr, Toronto, ON, Canada.
    Della Siega, Anthony
    Victoria Heart Inst Fdn, Dept Cardiac Serv, Victoria, BC, Canada.
    Mehta, Shamir R.
    McMaster Univ, Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada;Hamilton Hlth Sci, 237 Barton St East, Hamilton, ON L8L 2X2, Canada.
    Timing of Staged Nonculprit Artery Revascularization in Patients With ST-Segment Elevation Myocardial Infarction COMPLETE Trial2019In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 74, no 22, p. 2713-2723Article in journal (Refereed)
    Abstract [en]

    BACKGROUND The COMPLETE (Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Early PCI for STEMI) trial demonstrated that staged nonculprit lesion percutaneous coronary intervention (PCI) reduced major cardiovascular (CV) events in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease (CAD). OBJECTIVES The purpose of this study was to determine the effect of nonculprit-lesion PCI timing on major CV outcomes and also the time course of the benefit of complete revascularization. METHODS Following culprit-lesion PCI, 4,041 patients with STEMI and multivessel CAD were randomized to staged nonculprit-lesion PCI or culprit-lesion only PCI. Randomization was stratified according to investigator-planned timing of nonculprit-lesion PCI: during or after the index hospitalization. The first coprimary outcome was the composite of CV death or myocardial infarction (MI). In pre-specified analyses, hazard ratios (HRs) were calculated for each time stratum. Landmark analyses of the entire population were performed within 45 days and after 45 days. RESULTS For nonculprit-lesion PCI planned during the index hospitalization (actual time: median 1 day), CV death or MI was reduced with complete revascularization compared with culprit-lesion only PCI (HR: 0.77; 95% confidence interval [CI]: 0.59 to 1.00). For nonculprit lesion PCI planned to occur after hospital discharge (actual time: median 23 days), CV death or MI was also reduced with complete revascularization (HR: 0.69; 95% CI: 0.49 to 0.97; interaction p = 0.62). Landmark analyses demonstrated an HR of 0.86 (95% CI: 0.59 to 1.24) during the first 45 days and 0.69 (95% CI: 0.54 to 0.89) from 45 days to the end of follow-up for intended nonculprit lesion PCI versus culprit lesion only PCI. CONCLUSIONS Among STEMI patients with multivessel disease, the benefit of complete revascularization over culprit-lesion only PCI was consistent irrespective of the investigator-determined timing of nonculprit-lesion intervention. The benefit of complete revascularization on hard clinical outcomes emerged mainly over the long term. (C) 2019 by the American College of Cardiology Foundation.

  • 239062.
    Wood, Gavin
    et al.
    Northumbria Univ, Newcastle Upon Tyne, Tyne & Wear, England.
    Back, Jon
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Choi, Jaz Hee-jeong
    RMIT Univ, Melbourne, Vic, Australia.
    Dylan, Thomas
    Northumbria Univ, Newcastle Upon Tyne, Tyne & Wear, England.
    Louw, Marti
    Carnegie Mellon Univ, Human Comp Interact Inst, Pittsburgh, PA 15213 USA.
    Designing for Outdoor Play2019In: CHI EA '19 EXTENDED ABSTRACTS: EXTENDED ABSTRACTS OF THE 2019 CHI CONFERENCE ON HUMAN FACTORS IN COMPUTING SYSTEMS, ASSOC COMPUTING MACHINERY , 2019, article id W18Conference paper (Refereed)
    Abstract [en]

    There is widespread societal concern regarding the reduction in the amount of time that we all spend playing outdoors. Outdoor play can be important for our social and physical well-being and moreover helps us to connect to space, place and environment. Of course, the CHI community continues to explore play across many contexts; however, specifically designing for outdoor play remains underexplored. This workshop aims to bring together those who are interested in technological, social and design aspects of outdoor play for all ages. We will use participants' insights, energies and expertise to explore the challenges and focus on how we can build a community to share innovative designs, generate knowledge and make actionable research in this context.

  • 239063.
    Wood, George
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Finding Butehamun: Scribe of Deir el-Medina2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Butehamun was one of the most famous scribes involved in the building of the royal tombs of the Valley of the Kings, and a member of the most illustrious family of scribes there. Butehamun presided over the closure of the Valley and the workers’ village of Deir elMedina, and the move from building new tombs to the preserving and moving (some would say plundering) of the mummies left behind, marking the transition from the New Kingdom to the Third Intermediate Period, as Egypt splintered into what were essentially two realms. By studying the primary sources associated with Butehamun, including letters, reburial ‘dockets’, graffiti, the apparently unique decorations on Butehamun’s coffin, and the finds at his excavated house in Medinet Habu, this paper investigates what can be learned about Butehamun and the reburial project. Some of the sources seem to indicate he experienced some kind of religious crisis, which may have been brought on by feelings of guilt over his treatment of the royal mummies, two of whom were worshipped as gods in Deir el-Medina.

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    Finding Butehamun
  • 239064. Wood, Kirkham B.
    et al.
    Fritzell, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Center for Clinical Research Dalarna.
    Dettori, Joseph R.
    Hashimoto, Robin
    Lund, Teija
    Shaffrey, Chris
    Effectiveness of Spinal Fusion Versus Structured Rehabilitation in Chronic Low Back Pain Patients With and Without Isthmic Spondylolisthesis: A Systematic Review2011In: Spine, ISSN 0362-2436, E-ISSN 1528-1159, Vol. 36, no 21, p. S110-S119Article in journal (Refereed)
    Abstract [en]

    Study Design. Systematic review. Objective. To determine if the presence of isthmic spondylolisthesis modifies the effect of treatment (fusion vs. multidimensional supervised rehabilitation) in patients with chronic low back pain (CLBP). Summary of Background Data. Results of spinal surgery for CLBP are variable. It is unclear whether patients with CLBP and isthmic spondylolisthesis have more success with surgery versus a multidimensional supervised rehabilitation program when compared with those with CLBP but without spondylolisthesis. Methods. A systematic search was conducted in MEDLINE and the Cochrane Collaboration Library for articles published through January 2011. Randomized controlled trials (RCTs) were included that compared spine fusion versus multidimensional supervised rehabilitation in patients with and without isthmic spondylolisthesis. Standardized mean differences (SMDs) and risk differences were calculated for common outcomes, and then compared to determine potential heterogeneity of treatment effect. The final strength of the body of literature was expressed as "high," "moderate," or "low" confidence that the evidence reflects the true effect. Results. No studies were found that directly compared the two subgroups. Three RCTs compared fusion with supervised nonoperative care in patients with CLBP without isthmic spondylolisthesis; one RCT evaluated these treatments in patients with isthmic spondylolisthesis. There were study differences in patient characteristics, type of fusion, the nature of the rehabilitation, outcomes assessed, and length of follow-up. The SMDs for pain in favor of fusion were modest at 2 years for those without isthmic spondylolisthesis, but large in favor of fusion for those with isthmic spondylolisthesis compared with rehabilitation. Similarly, the SMDs for function in patients without isthmic spondylolisthesis compared with rehabilitation was small at 2 years, but appreciably higher in favor of fusion in patients with isthmic spondylolisthesis. Conclusion. The overall strength of evidence evaluating whether the presence of isthmic spondylolisthesis modifies the effect of fusion compared with rehabilitation patients with CLBP is "low." Fusion should be considered for patients with low back pain and isthmic spondylolisthesis who have failed nonoperative treatment. Clinical Recommendations. We recommend considering fusion for patients with isthmic spondylolisthesis and lower back pain who have failed nonoperative treatment. Recommendation: Weak.

  • 239065. Wood, Laura D
    et al.
    Parsons, D Williams
    Jones, Siân
    Lin, Jimmy
    Sjöblom, Tobias
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
    Leary, Rebecca J
    Shen, Dong
    Boca, Simina M
    Barber, Thomas
    Ptak, Janine
    Silliman, Natalie
    Szabo, Steve
    Dezso, Zoltan
    Ustyanksky, Vadim
    Nikolskaya, Tatiana
    Nikolsky, Yuri
    Karchin, Rachel
    Wilson, Paul A
    Kaminker, Joshua S
    Zhang, Zemin
    Croshaw, Randal
    Willis, Joseph
    Dawson, Dawn
    Shipitsin, Michail
    Willson, James K V
    Sukumar, Saraswati
    Polyak, Kornelia
    Park, Ben Ho
    Pethiyagoda, Charit L
    Pant, P V Krishna
    Ballinger, Dennis G
    Sparks, Andrew B
    Hartigan, James
    Smith, Douglas R
    Suh, Erick
    Papadopoulos, Nickolas
    Buckhaults, Phillip
    Markowitz, Sanford D
    Parmigiani, Giovanni
    Kinzler, Kenneth W
    Velculescu, Victor E
    Vogelstein, Bert
    The genomic landscapes of human breast and colorectal cancers.2007In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 318, no 5853, p. 1108-1113Article in journal (Refereed)
    Abstract [en]

    Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene "mountains" and a much larger number of gene "hills" that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.

  • 239066.
    Wood, Marilee
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    A glass bead sequence for southern Africa from the 8th to the 16th century AD2011In: Journal of African Archaeology, ISSN 1612-1651, E-ISSN 2191-5784, Vol. 9, no 1, p. 67-84Article in journal (Refereed)
    Abstract [en]

    Many tens of thousands of glass beads have been recovered from well-dated 8(th) to 16(th) century archaeological sites in southern Africa, making it possible to develop a temporally sensitive bead sequence which is made up of seven series. The series were developed based on morphological characteristics and recent chemical analysis has confirmed those results. The bead series are described in detail along with possible origins for the glass used to create them. Chemical composition of the glasses used to make the beads demonstrates that three major changes in glass chemistry occurred between the 8(th) and 15(th) centuries, suggesting the different glasses originated in geographically disparate regions and indicating that trade patterns connecting southern Africa to other Indian Ocean entities were far from static.

  • 239067.
    Wood, Marilee
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, African and Comparative Archaeology.
    Appendix 1: Chemical analysis results for beads and shards from Chibuene by glass type2012Other (Other academic)
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    Appendix 1 Wood M 2012
  • 239068.
    Wood, Marilee
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, African and Comparative Archaeology.
    Interconnections: Glass beads and trade in southern and eastern Africa and the Indian Ocean - 7th to 16th centuries AD2012Doctoral thesis, monograph (Other academic)
    Abstract [en]

    Glass beads comprise the most frequently found evidence of trade between southern Africa and the greater Indian Oceanbetween the 7th and 16th centuries AD.  In this thesis beads recovered from southern African archaeological sites are organized into series, based on morphology and chemical composition determined by LA-ICP-MS analysis.  The results are used to interpret the trade patterns and partners that linked eastern Africa to the rest of the Indian Ocean world, as well as interconnections between southern Africa andEast Africa.   Comprehensive reports on bead assemblages from several archaeological sites are presented, including: Mapungubwe, K2 and Schroda in the Shashe-Limpopo Basin; Chibuene in southern Mozambique; Hlamba Mlonga in eastern Zimbabwe; Sibudu Cave in KwaZulu-Natal, Kaole Ruins in Tanzania and Mahilaka in northwest Madagascar.  The conclusions reached show that trade relationships and socio-political development in the south were different from those on the East Coast and that changes in bead series in the south demonstrate it was fully integrated into the cycles of the Eurasian and African world-system.

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    fulltext
  • 239069.
    Wood, Marilee
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Dussubieux, Laure
    Robertshaw, Peter
    The glass of Chibuene, Mozambique: new insights into early Indian ocean trade2012In: South African Archaeological Bulletin, ISSN 0038-1969, E-ISSN 2224-4654, Vol. 67, no 195, p. 59-74Article in journal (Refereed)
    Abstract [en]

    Chibuene, southern Mozambique, is the site of the earliest-known trading port in southern Africa. Radiocarbon dates place its occupation between the 6th and 17th centuries. Recovered exotic trade goods, especially glass beads, indicate it was the main port of entry for that trade into southern Africa from roughly the 8th to the mid-10th century. LA-ICP-MS analysis of glass beads, vessel shards and wasters from the site has brought to light a new bead series for the region that may push that trade back to the 7th century. The chemical characteristics and possible origins of the three main glass types present are explored and the history of the site is interpreted through the evidence provided by the glass shards and beads - their absence at times being as revealing as their presence at others.

  • 239070. Wood, Robert J. K.
    et al.
    Bahaj, Abubakr S.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Turnock, Stephen R.
    Wang, Ling
    Evans, Martin-Halfdan
    Tribological design constraints of marine renewable energy systems2010In: Philosophical Transactions. Series A: Mathematical, physical, and engineering science, ISSN 1364-503X, E-ISSN 1471-2962Article in journal (Refereed)
    Abstract [en]

    Against the backdrop of increasing energy demands, the threat of climate change and dwindling fuel reserves, finding reliable, diverse, sustainable/renewable, affordable energy resources has become a priority for many countries. Marine energy conversion systems are at the forefront of providing such a resource. Most marine renewable energy conversion systems require tribological components to covert wind or tidal streams to rotational motion for generating electricity while wave machines typically use oscillating hinge or piston within cylinder geometries to promote reciprocating linear motion. This paper looks at the tribology of three green marine energy systems, offshore wind, tidal and wave machines. Areas covered include lubrication and contamination, bearing and gearbox issues, biofouling, cavitation erosion, tribocorrosion, condition monitoring as well as design trends and loading conditions associated with tribological components. Current research thrusts are highlighted along with areas needing research as well as addressing present day issues related to the tribology of offshore energy conversion technologies.

  • 239071.
    Wood, William A.
    et al.
    Univ N Carolina, Div Hematol Oncol, Dept Med, Chapel Hill, NC 27515 USA.
    Brazauskas, Ruta
    Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
    Hu, Zhen-Huan
    Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
    Abdel-Azim, Hisham
    Univ Southern Calif, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Keck Sch Med, Los Angeles, CA USA.
    Ahmed, Ibrahim A.
    Childrens Mercy Hosp & Clin, Dept Hematol Oncol & Bone Marrow Transplantat, Kansas City, MO USA.
    Aljurf, Mahmoud
    King Faisal Specialist Hosp & Res Ctr, Dept Oncol, Riyadh, Saudi Arabia.
    Badawy, Sherif
    Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplantat, Chicago, IL 60611 USA.
    Beitinjaneh, Amer
    Univ Miami, Dept Hematol Oncol, Miami, FL USA.
    George, Biju
    Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.
    Buchbinder, David
    Childrens Hosp Orange Cty, Div Pediat Hematol, Orange, CA 92668 USA.
    Cerny, Jan
    UMass Mem Med Ctr, Div Hematol Oncol, Worcester, MA USA.
    Dedeken, Laurence
    Hop Univ Enfants Reine Fabiola, Dept Hematol Oncol, Brussels, Belgium.
    Angel Diaz, Miguel
    Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.
    Freytes, Cesar O.
    Texas Transplant Inst, San Antonio, TX USA.
    Ganguly, Siddhartha
    Univ Kansas, Med Ctr, Blood & Marrow Transplantat, Div Hematol & Oncol, Kansas City, KS 66103 USA.
    Gergis, Usama
    Presbyterian Hosp, Hematolg Malignancies & Bone Marrow Transplant, Dept Med Oncol, Weill Cornell Med Ctr, New York, NY USA.
    Gomez Almaguer, David
    Hosp Univ Autonoma Nuevo Leon, Monterrey, Mexico.
    Gupta, Ashish
    Univ Hosp Cleveland, Seidman Canc Ctr, Med Ctr, Cleveland, OH 44106 USA.
    Hale, Gregory
    Johns Hopkins All Childrens Hosp, Dept Hematol Oncol, St Petersburg, FL USA.
    Hashmi, Shahrukh K.
    Mayo Clin, Dept Internal Med, Rochester, MN USA;King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia.
    Inamoto, Yoshihiro
    Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.
    Kamble, Rammurti T.
    Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.
    Adekola, Kehinde
    Northwestern Univ, Div Hematol Oncol, Dept Med, Chicago, IL 60611 USA;Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 USA.
    Kindwall-Keller, Tamila
    Univ Virginia Hlth Syst, Div Hematol Oncol, Charlottesville, VA USA.
    Knight, Jennifer
    Med Coll Wisconsin, Dept Psychol, Milwaukee, WI 53226 USA.
    Kumar, Lalit
    All India Inst Med Sci, Inst Rotary Canc Hosp, Dept Med Oncol, New Delhi, India.
    Kuwatsuka, Yachiyo
    Nagoya Univ, Ctr Adv Med & Clin Res, Grad Sch Med, Nagoya, Aichi, Japan.
    Law, Jason
    Floating Hosp Children, Tufts Med Ctr, Dept Pediat, Boston, MA USA.
    Lazarus, Hillard M.
    Univ Hosp Cleveland, Seidman Canc Ctr, Med Ctr, Cleveland, OH 44106 USA.
    LeMaistre, Charles
    Sarah Cannon, Hematol & Bone Marrow Transplant, Nashville, TN USA.
    Olsson, Richard
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden.
    Pulsipher, Michael A.
    Univ Southern Calif, Childrens Hosp Los Angeles, Div Hematol & Blood & Marrow Transplantat, Keck Sch Med, Los Angeles, CA USA.
    Savani, Bipin N.
    Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
    Schultz, Kirk R.
    Univ British Columbia, British Columbias Childrens Hosp, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Vancouver, BC, Canada.
    Saad, Ayman A.
    Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA.
    Seftel, Matthew
    CancerCare Manitoba, Dept Med Oncol & Hematol, Winnipeg, MB, Canada.
    Seo, Sachiko
    Natl Canc Res Ctr East, Dept Hematol & Oncol, Chiba, Japan.
    Shea, Thomas C.
    Univ N Carolina, Div Hematol Oncol, Dept Med, Chapel Hill, NC 27515 USA.
    Steinberg, Amir
    Mt Sinai Hosp, Dept Hematol Oncol, New York, NY 10029 USA.
    Sullivan, Keith
    Duke Univ, Med Ctr, Durham, NC USA.
    Szwajcer, David
    CancerCare Manitoba, Dept Med Oncol & Hematol, Winnipeg, MB, Canada.
    Wirk, Baldeep
    Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA.
    Yared, Jean
    Univ Maryland, Dept Med, Greenebaum Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.
    Yong, Agnes
    Univ Adelaide, Royal Adelaide Hosp, SA Pathol, Adelaide, SA, Australia;Univ Adelaide, Sch Med, Adelaide, SA, Australia.
    Dalal, Jignesh
    Univ Hosp Cleveland, Seidman Canc Ctr, Med Ctr, Cleveland, OH 44106 USA.
    Hahn, Theresa
    Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA.
    Khera, Nandita
    Mayo Clin, Dept Hematol Oncol, Phoenix, AZ USA.
    Bonfim, Carmem
    Hosp Clin Fed Univ Parana, Curitiba, Parana, Brazil.
    Atsuta, Yoshiko
    Nagoya Univ, Ctr Adv Med & Clin Res, Grad Sch Med, Nagoya, Aichi, Japan.
    Saber, Wael
    Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
    Country-Level Macroeconomic Indicators Predict Early Post-Allogeneic Hematopoietic Cell Transplantation Survival in Acute Lymphoblastic Leukemia: A CIBMTR Analysis2018In: Biology of blood and marrow transplantation, ISSN 1083-8791, E-ISSN 1523-6536, Vol. 24, no 9, p. 1928-1935Article in journal (Refereed)
    Abstract [en]

    For patients with acute lymphoblastic leukemia (ALL), allogeneic hematopoietic cell transplantation (alloHCT) offers a potential cure. Life-threatening complications can arise from alloHCT that require the application of sophisticated health care delivery. The impact of country-level economic conditions on post-transplantation outcomes is not known. Our objective was to assess whether these variables were associated with outcomes for patients transplanted for ALL. Using data from the Center for Blood and Marrow Transplant Research, we included 11,261 patients who received a first alloHCT for ALL from 303 centers across 38 countries between the years of 2005 and 2013. Cox regression models were constructed using the following macroeconomic indicators as main effects: Gross national income per capita, health expenditure per capita, and Human Development Index (HDI). The outcome was overall survival at 100 days following transplantation. In each model, transplants performed within lower resourced environments were associated with inferior overall survival. In the model with the HDI as the main effect, transplants performed in the lowest HDI quartile (n = 697) were associated with increased hazard for mortality (hazard ratio, 2.42; 95% confidence interval, 1.64 to 3.57; P < .001) in comparison with transplants performed in the countries with the highest HDI quartile. This translated into an 11% survival difference at 100 days (77% for lowest HDI quartile versus 88% for all other quartiles). Country-level macroeconomic indices were associated with lower survival at 100 days after alloHCT for ALL. The reasons for this disparity require further investigation.

  • 239072.
    Woodard, Jeremy
    et al.
    Univ KwaZulu Natal, Sch Agr, Geol Sci, Earth & Environm Sci, Private Bag X 54001, Durban, South Africa..
    Tuisku, Pekka
    Univ Oulu, Dept Geosciences, Oulu 90014, Finland..
    Kaerki, Aulis
    Univ Oulu, Dept Geosciences, Oulu 90014, Finland..
    Lahaye, Yann
    Geol Survey Finland, POB 96, Espoo 02151, Finland..
    Majka, Jaroslaw
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Mineralogy Petrology and Tectonics. AGH Univ Sci & Technol, Fac Geol, Geophys & Environm Protect, Mickiewicza 30, PL-30059 Krakow, Poland..
    Huhma, Hannu
    Geol Survey Finland, POB 96, Espoo 02151, Finland..
    Whitehouse, Martin J.
    Swedish Museum Nat Hist, Lab Isotope Geol, Box 50007, S-10405 Stockholm, Sweden..
    Zircon and monazite geochronology of deformation in the Pielavesi Shear Zone, Finland: multistage evolution of the Archaean-Proterozoic boundary in the Fennoscandian Shield2017In: Journal of the Geological Society, ISSN 0016-7649, E-ISSN 2041-479X, Vol. 174, no 2, p. 255-267Article in journal (Refereed)
    Abstract [en]

    The Raahe-Ladoga Shear Complex is a major crustal structure representing the Archaean-Palaeoproterozoic boundary in the Fennoscandian Shield. The complex developed during the Svecofennian Orogeny (c. 1.9 - 1.8 Ga) beginning with regional thrust tectonic phases D-1 and D-2, followed by large-scale shearing events D-3 and D-4. The Pielavesi Shear Zone is a vertical north-south-trending shear zone within the Raahe-Ladoga Shear Complex formed during regional D-3 shearing and later reactivated during the regional D-4 phase. Three north-south-trending elongate granitoid intrusions were selected as representative of silicic melts that intruded the transtensional Pielavesi Shear Zone during the regional D-3 phase. The oriented magmatic fabric of the granitoids indicates that they intruded coeval to the deformation event. The zircon U-(Th)-Pb secondary ionization mass spectrometry (SIMS) ages of these intrusions (1888 +/- 4, 1884 +/- 6 and 1883 +/- 5 Ma) overlap within error and provide a direct age for the regional D-3 deformation. epsilon(Hf(T)) (-1.1 to + 3.4) and epsilon(Nd(T)) (-1.2 to + 0.4) values from these granitoids are both consistent with a predominantly juvenile source affected by a minor Archaean component. U-(Th)-Pb SIMS analyses of metamorphic monazite formed within a crosscutting blastomylonite provide an age for the regional D-4 phase and associated fluid activity of 1793 +/- 3 Ma.

  • 239073. Woodbridge, Jessie
    et al.
    Roberts, C. Neil
    Palmisano, Alessio
    Bevan, Andrew
    Shennan, Stephen
    Fyfe, Ralph
    Eastwood, Warren J.
    Izdebski, Adam
    Çakırlar, Canan
    Woldring, Henk
    Broothaerts, Nils
    Kaniewski, David
    Finné, Martin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Classical archaeology and ancient history.
    Labuhn, Inga
    Pollen-inferred regional vegetation patterns and demographic change in Southern Anatolia through the Holocene2019In: The Holocene, ISSN 0959-6836, E-ISSN 1477-0911, Vol. 29, no 5, p. 728-741Article in journal (Refereed)
    Abstract [en]

    Southern Anatolia is a highly significant area within the Mediterranean, particularly in terms of understanding how agriculture moved into Europe from neighbouring regions. This study uses pollen, palaeoclimate and archaeological evidence to investigate the relationships between demography and vegetation change, and to explore how the development of agriculture varied spatially. Data from 21 fossil pollen records have been transformed into forested, parkland and open vegetation types using cluster analysis. Patterns of change have been explored using non-metric multidimensional scaling (nMDS) and through analysis of indicator groups, such as an Anthropogenic Pollen Index, and Simpson’s Diversity. Settlement data, which indicate population densities, and summed radiocarbon dates for archaeological sites have been used as a proxy for demographic change. The pollen and archaeological records confirm that farming can be detected earlier in Anatolia in comparison with many other parts of the Mediterranean. Dynamics of change in grazing indicators and the OJCV (Olea, Juglans, Castanea and Vitis) index for cultivated trees appear to match cycles of population expansion and decline. Vegetation and land use change is also influenced by other factors, such as climate change. Investigating the early impacts of anthropogenic activities (e.g. woodcutting, animal herding, the use of fire and agriculture) is key to understanding how societies have modified the environment since the mid–late Holocene, despite the capacity of ecological systems to absorb recurrent disturbances. The results of this study suggest that shifting human population dynamics played an important role in shaping land cover in central and southern Anatolia.

  • 239074.
    Woodford, Joanne
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Wikman, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Cernvall, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Ljungman, Gustaf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Neuropediatrics/Paediatric oncology.
    Romppala, Amanda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Grönqvist, Helena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    von Essen, Louise
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Study protocol for a feasibility study of an internet-administered, guided, CBT-based, self-help intervention (ENGAGE) for parents of children previously treated for cancer2018In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, no 6, article id e023708Article in journal (Refereed)
    Abstract [en]

    INTRODUCTION: A subgroup of parents of children previously treated for cancer report long-term psychological distress after end of treatment. However, needs for psychological support are commonly unmet and there is a lack of evidence-based treatments tailored to the specific needs of this population. An internet-administered, guided, cognitive-behavioural therapy-based, self-help intervention (ENGAGE) for parents of children previously treated for cancer may provide a solution. The aim is to examine the feasibility and acceptability of the intervention ENGAGE and the study procedures for a future controlled trial.

    METHODS AND ANALYSIS: The study has an uncontrolled within-group design with an embedded qualitative and quantitative process evaluation. Potential participants are parents of children previously treated for cancer, living in Sweden, recruited via their child's personal identification number (via the Swedish Childhood Cancer Registry and the Swedish Tax Agency). Parents are invited randomly with information packs sent to home addresses. Further interest in participating can be registered via information on relevant websites. The study aims to recruit 50 parents who will receive the intervention ENGAGE which is designed to be delivered over a 10-week period, and comprises one introductory chapter followed by up to 10 intervention modules addressing key concerns identified for the population. Consistent with feasibility study objectives, primary outcomes relate to recruitment, attrition, data collection, study resources, intervention delivery and acceptability. Clinical outcomes (post-traumatic stress, depression, anxiety, fear of cancer recurrence, psychological inflexibility and experiential avoidance, depressed inactivity, fatigue, quality of life and self-compassion) will be measured at baseline, post-treatment (12 weeks) and 6-month follow-up.

    ETHICS AND DISSEMINATION: The Regional Ethical Review Board in Uppsala, Sweden has granted approval for the study (Dnr: 2017/527). Results will be disseminated to relevant healthcare and patient communities, in peer-reviewed and popular science journals, and at scientific and clinical conferences.

    TRIAL REGISTRATION NUMBER: ISRCTN57233429; Pre-results.

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  • 239075.
    Woodford, Joanne
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Wikman, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Einhorn, Kim
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Cernvall, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Grönqvist, Helena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Romppala, Amanda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    von Essen, Louise
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Attitudes and Preferences Toward a Hypothetical Trial of an Internet-Administered Psychological Intervention for Parents of Children Treated for Cancer: Web-Based Survey2018In: Journal of Medical Internet Research, ISSN 1438-8871, E-ISSN 1438-8871, Vol. 5, no 4, article id e10085Article in journal (Refereed)
    Abstract [en]

    Background:

    Clinical trials are often challenged with issues of recruitment and retention. Little is known concerning general attitudes and preferences toward trial design and willingness to participate among parents of children treated for cancer. Furthermore, willingness to participate in internet-administered psychological interventions remains unexplored. In this study, we examined attitudes and preferences of the population regarding study procedures for a hypothetical trial of an internet-administered psychological intervention. In addition, differences in the response rate between modes of study invitation and willingness to engage in internet-administered interventions were examined.

    Objective:

    The primary objective of this study was to examine attitudes and preferences toward participating in an internet-administrated psychological intervention. The secondary objective was to examine the response rates and help-seeking behavior among parents of children treated for cancer.

    Methods:

    A cross-sectional, Web-based survey was conducted with parents of children who had completed cancer treatment. This Web-based survey examined self-reported emotional distress, prior help-seeking and receipt of psychological support, past research participation, attitudes toward research, preferences concerning recruitment procedures, and attitudes toward different types of trial design.

    Results:

    Of all the parents invited, 32.0% (112/350) completed the survey, with no difference in response rate between modes of study invitation (χ21=0.6, P=.45). The majority (80/112, 71.4%) of parents responded that they had experienced past emotional distress. Responses indicated high (56/112, 50.0%) or somewhat high trust in research (51/112, 45.5%), and the majority of parents would accept, or maybe accept, internet-administered psychological support if offered (83/112, 74.1%). In addition, responses showed a preference for postal study invitation letters (86/112, 76.8%), sent by a researcher (84/112, 75.0%) with additional study information provided on the Web via text (81/112, 72.3%) and video (66/112, 58.9%). Overall, parents responded that trials utilizing a waiting list control, active alternative treatment control, or a patient-preference design were acceptable.

    Conclusions:

    Parents of children treated for cancer appear willing to participate in trials examining internet-administered psychological support. Findings of this study will inform the design of a feasibility trial examining internet-administered psychological support for the population.

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  • 239076.
    Woods, Marie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Med fokus på slutet av tunneln: anhörigas upplevelser av sin livssituation i den akuta fasen av allogen stamcellstransplantation2011Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The aim of this study was to describe family members’ experience of life during the acute phase of allogenic stem cell transplantation. Seven family members of patients at, “Centrum for Allogenic Stem cell transplantation” Karolinska University Hospital in Huddinge participated. The method used was semistruktured interviews that allowed the respondents to tell about their living situation. These interviews were then analyzed through qualitative content analysis. The findings were a theme named; this present time consisting of three categories: living-pieces, family and health. There were also ten subcategories all together. The result was that when family members gives the opportunity to, with their own words, describe and tell about their living situation they tell about the present time and how they focus and mobilise all their strength and energy on their sick family member to get well. The conclusion of this study was that further research and development of interventions, for family members, are necessary and to focus on the family as a unite is an absolute condition in order to maintain health and prevent physical- and mental illness for the whole family. This ought to be beneficial not only for the family but also for the patients’ recovery.

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  • 239077.
    Woodward, A.
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Ellig, J.
    Burns, Tom R.
    Municipal Entrepreneurship and Energy Policy: A Five Nation Study of Politics, Innovation, and Social Change1994Book (Other academic)
  • 239078.
    Wookey, PA
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Earth Sciences, Department of Earth Sciences. ENVIRONMENT AND LANDSCAPE DYNAMICS.
    Tundra2002In: Encyclopedia of Global Environmental Change, Volume 2: The Earth System - biological and ecological dimensions of global environmental change., Wiley, London , 2002, Vol. 2, p. 593-602Chapter in book (Refereed)
  • 239079.
    Wookey PA, Bol, RA, Caseldine CJ, Harkness DD
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Earth Sciences, Department of Earth Sciences. ENVIRONMENT AND LANDSCAPE DYNAMICS.
    Surface age, ecosystem development, and C isotope signatures of respired CO2 in an alpine environment, north Iceland2002In: Arctic, Antarctic, and Alpine Research, ISSN ISSN 1523-0430, Vol. 34, p. 76-87Article in journal (Refereed)
    Abstract [en]

    We studied the late Holocene foreland and adjacent unglaciated terrain of a small cirque glacier system in north Iceland to explore the relationship between soil/surface age, vegetation and soil evolution, and C isotope signatures of respired CO2. Field-b

  • 239080. Woolf, A D
    et al.
    Zeidler, H
    Haglund, U
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Carr, A J
    Chaussade, S
    Cucinotta, D
    Veale, D J
    Martin-Mola, E
    Musculoskeletal pain in Europe: its impact and a comparison of population and medical perceptions of treatment in eight European countries.2004In: Ann Rheum Dis, ISSN 0003-4967, Vol. 63, no 4, p. 342-7Article in journal (Refereed)
  • 239081.
    Woolf, C
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Bennett, GJ
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Doherty, M
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Dubner, R
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Kidd, B
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Koltzenburg, M
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Lipton, R
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Loeser, JD
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Payne, R
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Torebjork, E
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Towards a mechanism-based classification of pain?1998In: Pain, Vol. 77, p. 227-Article in journal (Refereed)
  • 239082. Woolf, CJ
    et al.
    Bennett, GJ
    Doherty, M
    Dubner, R
    Kidd, B
    Koltzenburg, M
    Lipton, R
    Loeser, JD
    Payne, R
    Torebjork, E
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Towards a mechanism-based classification of pain? [editorial]1999In: Pain, Vol. 77, p. 227-Article in journal (Refereed)
  • 239083. Woolfenden, Susan
    et al.
    Eapen, Valsamma
    Axelsson, Emma L
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Hendry, Alexandra
    Jalaludin, Bin
    Dissanayake, Cheryl
    Overs, Bronwyn
    Descallar, Joseph
    <