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  • 246751.
    Zeng, Cheng-Ming
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry.
    New approaches in biomembrane chromatomatography and microchromatographic techniques1998Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Development of methods for rendering chromatography more applicable to studies in lifesciences remains an area of active research. In the present work, new methods inbiomembrane chromatography and microchromatographic techniques have been developedand applied successfully to quantitative analysis of biological interactions and separations ofproteins on a micro-scale.

    Biomembranes, specifically: human red cells/ghosts, membrane vesicles and proteoliposomes, were immobilized in gel beds for chromatographic analyses of solutes specificallybound to the glucose transporter Glut1 and the nucleoside transporter of the red cellmembrane. The resultant binding parameters revealed that this system can be a practical toolfor quantitative analysis of biological interactions involving integral membrane proteins andfor monitoring procedures for purification and reconstitution of membrane proteins. Analternative method based on Hummel and Dreyer analysis was introduced and proved usefulin analyses of cytochalasin-B binding to Glut1 in membrane vesicles and proteoliposomes.

    Chromatographic analysis of non-specific partitioning of a drug into lipid bilayers wasperformed on a microcolumn containing liposomes immobilized in the gel bed. The resultsshowed that this method can be utilized for predicting absorption of a drug in vivo.Hydrophobic interaction microchromatography of proteins and a blotting membranetechnique for detection of minute amounts of proteins have been developed on the basis ofcontinuous beds which can be synthesized directly in the microcolumn tubes. Thesedevelopments extend the uses of continuous beds to a broader field in life science.

  • 246752.
    Zeng, Chenjie
    et al.
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med, 2525 West End Ave,8th Floor, Nashville, TN 37203 USA..
    Guo, Xingyi
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med, 2525 West End Ave,8th Floor, Nashville, TN 37203 USA..
    Long, Jirong
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med, 2525 West End Ave,8th Floor, Nashville, TN 37203 USA..
    Kuchenbaecker, Karoline B.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England..
    Droit, Arnaud
    Univ Laval, Prote Ctr, CHU Quebec Res Ctr, Quebec City, PQ G1K 7P4, Canada.;Univ Laval, Dept Mol Med, Quebec City, PQ G1K 7P4, Canada..
    Michailidou, Kyriaki
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England..
    Ghoussaini, Maya
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England..
    Kar, Siddhartha
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England..
    Freeman, Adam
    St Vincent Hosp, Dept Surg, Melbourne, Vic, Australia..
    Hopper, John L.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia..
    Milne, Roger L.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia..
    Bolla, Manjeet K.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England..
    Wang, Qin
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England..
    Dennis, Joe
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England..
    Agata, Simona
    IRCCS, IOV, Immunol & Mol Oncol Unit, Padua, Italy..
    Ahmed, Shahana
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England..
    Aittomaki, Kristiina
    Univ Helsinki, Helsinki Univ Hosp, Dept Clin Genet, Helsinki, Finland..
    Andrulis, Irene L.
    Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada..
    Anton-Culver, Hoda
    Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA..
    Antonenkova, Natalia N.
    NN Alexandrov Res Inst Oncol & Med Radiol, Minsk, Byelarus..
    Arason, Adalgeir
    Landspitali Univ Hosp, Dept Pathol, Reykjavik, Iceland.;Univ Iceland, Fac Med, BMC Biomed Ctr, Reykjavik, Iceland..
    Arndt, Volker
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany..
    Arun, Banu K.
    Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA..
    Arver, Brita
    Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden..
    Bacot, Francois
    McGill Univ, Montreal, PQ, Canada.;Genome Quebec Innovat Ctr, Montreal, PQ, Canada..
    Barrowdale, Daniel
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England..
    Baynes, Caroline
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England..
    Beeghly-Fadiel, Alicia
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med, 2525 West End Ave,8th Floor, Nashville, TN 37203 USA..
    Benitez, Javier
    Spanish Natl Canc Res Ctr, Human Canc Genet Program, Madrid, Spain.;Ctr Invest Red Enfermedades Raras, Valencia, Spain..
    Bermisheva, Marina
    Russian Acad Sci, Ufa Sci Ctr, Inst Biochem & Genet, Ufa, Russia..
    Blomqvist, Carl
    Univ Helsinki, Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland..
    Blot, William J.
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med, 2525 West End Ave,8th Floor, Nashville, TN 37203 USA.;Int Epidemiol Inst, Rockville, MD USA..
    Bogdanova, Natalia V.
    Hannover Med Sch, Dept Radiat Oncol, Hannover, Germany..
    Bojesen, Stig E.
    Copenhagen Univ Hosp, Herlev Hosp, Copenhagen Gen Populat Study, Herlev, Denmark.;Copenhagen Univ Hosp, Herlev Hosp, Dept Clin Biochem, Herlev, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark..
    Bonanni, Bernardo
    Ist Europeo Oncol, Div Canc Prevent & Genet, Milan, Italy..
    Borresen-Dale, Anne-Lise
    Radiumhosp, Oslo Univ Hosp, Inst Canc Res, Dept Genet, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, KG Jebsen Ctr Breast Canc Res, Oslo, Norway..
    Brand, Judith S.
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Brauch, Hiltrud
    Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany.;Univ Tubingen, Tubingen, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany..
    Brennan, Paul
    Int Agcy Res Canc, Lyon, France..
    Brenner, Hermann
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany..
    Broeks, Annegien
    Radiumhosp, Oslo Univ Hosp, Inst Canc Res, Dept Genet, Oslo, Norway.;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Amsterdam, Netherlands..
    Bruening, Thomas
    Inst Ruhr Univ Bochum, Inst Prevent & Occupat Med German Social Accident, Bochum, Germany..
    Burwinkel, Barbara
    Heidelberg Univ, Dept Obstet & Gynecol, Heidelberg, Germany.;German Canc Res Ctr, Mol Epidemiol Grp, Heidelberg, Germany..
    Buys, Saundra S.
    Univ Utah, Sch Med, Dept Med, Huntsman Canc Inst, Salt Lake City, UT USA..
    Cai, Qiuyin
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med, 2525 West End Ave,8th Floor, Nashville, TN 37203 USA..
    Caldes, Trinidad
    Hosp Clin San Carlos, IdISSC Inst Invest Sanitaria Hosp Clin San Carlos, Mol Oncol Lab, Madrid, Spain..
    Campbell, Ian
    Peter MacCallum Canc Ctr, Canc Gene Lab, Melbourne, Vic, Australia..
    Carpenter, Jane
    Univ Sydney, Westmead Millennium Inst, Australian Breast Canc Tissue Bank, Sydney, NSW, Australia..
    Chang-Claude, Jenny
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Med Ctr Hamburg Eppendorf, UCCH, Hamburg, Germany..
    Choi, Ji-Yeob
    Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.;Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea.;Seoul Natl Univ, Canc Res Inst, Seoul, South Korea..
    Claes, Kathleen B. M.
    Univ Ghent, Ctr Med Genet, Ghent, Belgium..
    Clarke, Christine
    Univ Sydney, Westmead Millenium Inst Med Res, Sydney, NSW, Australia..
    Cox, Angela
    Univ Sheffield, Dept Oncol, Sheffield Canc Res, Sheffield, S Yorkshire, England..
    Cross, Simon S.
    Univ Sheffield, Dept Neurosci, Acad Unit Pathol, Sheffield, S Yorkshire, England..
    Czene, Kamila
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Daly, Mary B.
    Fox Chase Canc Ctr, Dept Clin Genet, 7701 Burholme Ave, Philadelphia, PA 19111 USA..
    de la Hoya, Miguel
    Hosp Clin San Carlos, IdISSC Inst Invest Sanitaria Hosp Clin San Carlos, Mol Oncol Lab, Madrid, Spain..
    De Leeneer, Kim
    Univ Ghent, Ctr Med Genet, Ghent, Belgium..
    Devilee, Peter
    Leiden Univ, Med Ctr, Dept Pathol, Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands..
    Diez, Orland
    Univ Hosp Vall dHebron, VHIO, Oncogenet Grp, Barcelona, Spain.;Univ Autonoma Barcelona, Barcelona, Spain..
    Domchek, Susan M.
    Univ Penn, Dept Med, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA..
    Doody, Michele
    NCI, Div Canc Epidemiol & Genet, Rockville, MD USA..
    Dorfling, Cecilia M.
    Univ Pretoria, Dept Genet, Pretoria, South Africa..
    Doerk, Thilo
    Hannover Med Sch, Clin Obstet & Gynaecol, Hannover, Germany..
    dos-Santos-Silva, Isabel
    London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England..
    Dumont, Martine
    Univ Laval, Ctr Hosp Univ Quebec Res Ctr, Genom Ctr, Quebec City, PQ, Canada..
    Dwek, Miriam
    Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, London, England..
    Dworniczak, Bernd
    Inst Human Genet, Munster, Germany..
    Egan, Kathleen
    H Lee Moffitt Canc Ctr & Res Inst, Div Populat Sci, Tampa, FL USA..
    Eilber, Ursula
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany..
    Einbeigi, Zakaria
    Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden..
    Ejlertsen, Bent
    Copenhagen Univ Hosp, Rigshosp, Dept Oncol, Copenhagen, Denmark..
    Ellis, Steve
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England..
    Frost, Debra
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England..
    Lalloo, Fiona
    Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Genet Med, Manchester, Lancs, England..
    Fasching, Peter A.
    Univ Erlangen Nurnberg, Comprehens Canc Ctr Erlangen EMN, Univ Hosp Erlangen, Dept Gynecol & Obstet, Erlangen, Germany.;Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, Los Angeles, CA 90095 USA..
    Figueroa, Jonine
    NCI, Div Canc Epidemiol & Genet, Rockville, MD USA..
    Flyger, Henrik
    Copenhagen Univ Hosp, Herlev Hosp, Dept Breast Surg, Herlev, Denmark..
    Friedlander, Michael
    Australia New Zealand GOG, ANZ GOTG Coordinating Ctr, Camperdown, NSW, Australia..
    Friedman, Eitan
    Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Tel Hashomer, Israel..
    Gambino, Gaetana
    Univ Pisa, Deparment Lab Med, Sect Genet Oncol, Pisa, Italy.;Univ Hosp Pisa, Pisa, Italy..
    Gao, Yu-Tang
    Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China..
    Garber, Judy
    Dana Farber Canc Inst, Canc Risk & Prevent Clin, Boston, MA 02115 USA..
    Garcia-Closas, Montserrat
    NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.;Inst Canc Res, Div Genet & Epidemiol, London, England..
    Gehrig, Andrea
    Univ Wurzburg, Inst Human Genet, Wurzburg, Germany..
    Damiola, Francesca
    Univ Lyon, CNRS, INSERM, Ctr Rech Cancerol Lyon,U1052,UMR5286, Lyon, France..
    Lesueur, Fabienne
    Mines ParisTech, Inst Curie, INSERM, Genet Epidemiol Canc Team,U900, F-75248 Paris, France..
    Mazoyer, Sylvie
    Univ Lyon, CNRS, INSERM, Ctr Rech Cancerol Lyon,U1052,UMR5286, Lyon, France..
    Stoppa-Lyonnet, Dominique
    Inst Curie, Dept Tumor Biol, Paris, France.;INSERM, Inst Curie, U830, Paris, France.;Univ Paris 05, Sorbonne Paris Cite, Paris, France..
    Giles, Graham G.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia..
    Godwin, Andrew K.
    Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.;Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA..
    Goldgar, David E.
    Univ Utah, Sch Med, Huntsman Canc Inst, Dept Dermatol, Salt Lake City, UT USA..
    Gonzalez-Neira, Anna
    Spanish Natl Canc Res Ctr, Human Canc Genet Program, Madrid, Spain..
    Greene, Mark H.
    NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA..
    Guenel, Pascal
    INSERM, Ctr Res Epidemiol & Populat Hlth, Environm Epidemiol Canc, Villejuif, France.;Univ Paris 11, Villejuif, France..
    Haeberle, Lothar
    Univ Erlangen Nurnberg, Comprehens Canc Ctr Erlangen EMN, Univ Hosp Erlangen, Dept Gynecol & Obstet, Erlangen, Germany..
    Haiman, Christopher A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA..
    Hallberg, Emily
    Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA..
    Hamann, Ute
    German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany..
    Hansen, Thomas V. O.
    Copenhagen Univ Hosp, Rigshosp, Ctr Genom Med, Copenhagen, Denmark..
    Hart, Steven
    Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA..
    Hartikainen, Jaana M.
    Kuopio Univ Hosp, Ctr Canc, Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Pathol, Imaging Ctr, Kuopio, Finland..
    Hartman, Mikael
    Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Natl Univ Hlth Syst, Dept Surg, Singapore, Singapore..
    Hassan, Norhashimah
    Canc Res Initiat Fdn, Subang Jaya, Selangor, Malaysia.;Univ Malaya, Med Ctr, Canc Res Inst, Breast Canc Res Unit, Kuala Lumpur, Malaysia..
    Healey, Sue
    QIMR Berghofer Med Res Inst, Canc Div, Brisbane, Qld, Australia..
    Hogervorst, Frans B. L.
    Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands..
    Verhoef, Senno
    Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands..
    Hendricks, Carolyn B.
    Suburban Hosp, Bethesda, MD USA.;City Hope Natl Med Ctr, Clin Canc Genet Community Res Network, Duarte, CA USA..
    Hillemanns, Peter
    Hannover Med Sch, Clin Obstet & Gynaecol, Hannover, Germany..
    Hollestelle, Antoinette
    Erasmus MC Canc Inst, Family Canc Clin, Dept Med Oncol, Rotterdam, Netherlands..
    Hulick, Peter J.
    NorthShore Univ HealthSyst, Ctr Med Genet, Evanston, IL USA..
    Hunter, David J.
    Harvard Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.;Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA..
    Imyanitov, Evgeny N.
    NN Petrov Inst Oncol, St Petersburg, Russia..
    Isaacs, Claudine
    Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA..
    Ito, Hidemi
    Aichi Canc Ctr Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, Japan..
    Jakubowska, Anna
    Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland..
    Janavicius, Ramunas
    State Res Inst, Ctr Innovat Med, Vilnius, Lithuania..
    Jaworska-Bieniek, Katarzyna
    Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland..
    Jensen, Uffe Birk
    Aarhus Univ Hosp, Dept Clin Genet, Aarhus N, Denmark..
    John, Esther M.
    Canc Prevent Inst Calif, Dept Epidemiol, Fremont, CA USA.;Stanford Univ, Sch Med, Dept Hlth Res & Policy Epidemiol, Stanford, CA 94305 USA.;Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA..
    Beauparlant, Charles Joly
    Ctr Hosp Univ Quebec Res Ctr, Genom Ctr, Quebec City, PQ, Canada.;Univ Laval, Quebec City, PQ, Canada..
    Jones, Michael
    Inst Canc Res, Div Genet & Epidemiol, London, England..
    Kabisch, Maria
    German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany..
    Kang, Daehee
    Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.;Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea.;Seoul Natl Univ, Canc Res Inst, Seoul, South Korea..
    Karlan, Beth Y.
    Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Los Angeles, CA 90048 USA..
    Kauppila, Saila
    Univ Oulu, Oulu Univ Hosp, Dept Pathol, Oulu, Finland..
    Kerin, Michael J.
    Natl Univ Ireland, Sch Med, Galway, Ireland..
    Khan, Sofia
    Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland..
    Khusnutdinova, Elza
    Russian Acad Sci, Ufa Sci Ctr, Inst Biochem & Genet, Ufa, Russia.;Bashkir State Univ, Dept Genet & Fundamental Med, Ufa, Russia..
    Knight, Julia A.
    Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Prosserman Ctr Hlth Res, Toronto, ON, Canada.;Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada..
    Konstantopoulou, Irene
    Natl Ctr Sci Res Demokritos, IRRP, Mol Diagnost Lab, Athens, Greece..
    Kraft, Peter
    Harvard Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.;Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA..
    Kwong, Ava
    Hong Kong Sanat & Hosp, Canc Genet Ctr, Hong Kong Hereditary Breast Canc Family Registry, Hong Kong, Hong Kong, Peoples R China.;Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China..
    Laitman, Yael
    Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Tel Hashomer, Israel..
    Lambrechts, Diether
    Vesalius Res Ctr, Leuven, Belgium.;Univ Leuven, Dept Oncol, Lab Translat Genet, Leuven, Belgium..
    Lazaro, Conxi
    Catalan Inst Oncol, IDIBELL Bellvitge Biomed Res Inst, Hereditary Canc Program, Mol Diagnost Unit, Barcelona, Spain..
    Le Marchand, Loic
    Univ Hawaii, Ctr Canc, Honolulu, HI USA..
    Lee, Chuen Neng
    Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore..
    Lee, Min Hyuk
    Soonchunhyang Univ & Hosp, Dept Surg, Seoul, South Korea..
    Lester, Jenny
    Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Los Angeles, CA 90048 USA..
    Li, Jingmei
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Liljegren, Annelie
    Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden..
    Lindblom, Annika
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
    Lophatananon, Artitaya
    Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry, W Midlands, England..
    Lubinski, Jan
    Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland..
    Mai, Phuong L.
    NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA..
    Mannermaa, Arto
    Kuopio Univ Hosp, Ctr Canc, Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Pathol, Imaging Ctr, Kuopio, Finland..
    Manoukian, Siranoush
    INT, Fdn IRCCS Ist Ricovero Cura Carattere Sci, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy..
    Margolin, Sara
    Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden..
    Marme, Frederik
    Heidelberg Univ, Dept Obstet & Gynecol, Heidelberg, Germany.;Heidelberg Univ, Natl Ctr Tumor Dis, Heidelberg, Germany..
    Matsuo, Keitaro
    Kyushu Univ, Fac Med Sci, Dept Prevent Med, Fukuoka, Japan..
    McGuffog, Lesley
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England..
    Meindl, Alfons
    Tech Univ Munich, Div Gynaecol & Obstet, Munich, Germany..
    Menegaux, Florence
    INSERM, Ctr Res Epidemiol & Populat Hlth, Environm Epidemiol Canc, Villejuif, France.;Univ Paris 11, Villejuif, France..
    Montagna, Marco
    IRCCS, IOV, Immunol & Mol Oncol Unit, Padua, Italy..
    Muir, Kenneth
    Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry, W Midlands, England.;Univ Manchester, Inst Populat Hlth, Manchester, Lancs, England..
    Mulligan, Anna Marie
    Univ Hlth Network, Lab Med Program, Toronto, ON, Canada.;Univ Toronto, Dept Lab Med & Pathol, Toronto, ON, Canada..
    Nathanson, Katherine L.
    Univ Penn, Dept Med, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA..
    Neuhausen, Susan L.
    City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA USA..
    Nevanlinna, Heli
    Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland..
    Newcomb, Polly A.
    Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA.;Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA USA..
    Nord, Silje
    Radiumhosp, Oslo Univ Hosp, Inst Canc Res, Dept Genet, Oslo, Norway..
    Nussbaum, Robert L.
    Univ Calif San Francisco, Dept Med Genet, San Francisco, CA 94143 USA..
    Offit, Kenneth
    Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, Clin Genet Res Lab, 1275 York Ave, New York, NY 10021 USA.;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA..
    Olah, Edith
    Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary..
    Olopade, Olufunmilayo I.
    Univ Chicago, Med Ctr, Ctr Clin Canc Genet & Global Hlth, Chicago, IL 60637 USA..
    Olswold, Curtis
    Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA..
    Osorio, Ana
    Spanish Natl Canc Ctr CNIO, Human Canc Genet Program, Human Genet Grp, Madrid, Spain.;Biomed Network Rare Dis CIBERER, Madrid, Spain..
    Papi, Laura
    Univ Florence, Dept Biomed Expt & Clin Sci, Unit Med Genet, Florence, Italy..
    Park-Simon, Tjoung-Won
    Hannover Med Sch, Clin Obstet & Gynaecol, Hannover, Germany..
    Paulsson-Karlsson, Ylva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Peeters, Stephanie
    Univ Hosp Gasthuisberg, Leuven, Belgium..
    Peissel, Bernard
    INT, Fdn IRCCS Ist Ricovero Cura Carattere Sci, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy..
    Peterlongo, Paolo
    Fdn Ist FIRC Italian Fdn Canc Res Oncol Mol, IFOM, Milan, Italy..
    Peto, Julian
    London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England..
    Pfeiler, Georg
    Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria.;Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria..
    Phelan, Catherine M.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA..
    Presneau, Nadege
    Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, London, England..
    Radice, Paolo
    INT, Fdn IRCCS Ist Ricovero & Cura Carattere Sci, Dept Prevent & Predict Med, Unit Mol Bases Genet Risk & Genet Testing, Milan, Italy..
    Rahman, Nazneen
    Inst Canc Res, Sect Canc Genet, London, England..
    Ramus, Susan J.
    Univ Southern Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA 90033 USA..
    Rashid, Muhammad Usman
    German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany.;SKMCH & RC, Dept Basic Sci, Lahore, Pakistan..
    Rennert, Gad
    Clalit Natl Israeli Canc Control Ctr, Haifa, Israel.;Carmel Hosp, Dept Community Med & Epidemiol, Haifa, Israel.;B Rappaport Fac Med, Haifa, Israel..
    Rhiem, Kerstin
    Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Dept Obstet & Gynaecol, Cologne, Germany.;Univ Hosp Cologne, CIO, CMMC, Cologne, Germany..
    Rudolph, Anja
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany..
    Salani, Ritu
    Ohio State Univ, Coll Med, Obstet & Gynecol, Columbus, OH 43210 USA..
    Sangrajrang, Suleeporn
    Natl Canc Inst, Bangkok, Thailand..
    Sawyer, Elinor J.
    Kings Coll London, Guys Hosp, Res Oncol, London, England..
    Schmidt, Marjanka K.
    Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Amsterdam, Netherlands..
    Schmutzler, Rita K.
    Univ Hosp Cologne, Dept Obstet & Gynaecol, Div Mol Gynecooncol, Cologne, Germany.;Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany.;Univ Hosp Cologne, Ctr Integrated Oncol, Cologne, Germany.;Univ Hosp Cologne, Ctr Mol Med, Cologne, Germany..
    Schoemaker, Minouk J.
    Inst Canc Res, Div Genet & Epidemiol, London, England..
    Schuermann, Peter
    Hannover Med Sch, Clin Obstet & Gynaecol, Hannover, Germany..
    Seynaeve, Caroline
    Erasmus MC Canc Inst, Family Canc Clin, Dept Med Oncol, Rotterdam, Netherlands..
    Shen, Chen-Yang
    China Med Univ, Sch Publ Hlth, Taichung, Taiwan.;Acad Sinica, Inst Biomed Sci, Taiwan Biobank, Taipei, Taiwan..
    Shrubsole, Martha J.
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med, 2525 West End Ave,8th Floor, Nashville, TN 37203 USA..
    Shu, Xiao-Ou
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med, 2525 West End Ave,8th Floor, Nashville, TN 37203 USA..
    Sigurdson, Alice
    NCI, Div Canc Epidemiol & Genet, Rockville, MD USA..
    Singer, Christian F.
    Med Univ Vienna, Ctr Comprehens Canc, Dept Obstet & Gynecol, Vienna, Austria..
    Slager, Susan
    Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA..
    Soucy, Penny
    Ctr Hosp Univ Quebec Res Ctr, Quebec City, PQ, Canada.;Univ Laval, Quebec City, PQ, Canada..
    Southey, Melissa
    Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic, Australia..
    Steinemann, Doris
    Univ Lyon, CNRS, INSERM, Ctr Rech Cancerol Lyon,U1052,UMR5286, Lyon, France.;Hannover Med Sch, Hannover, Germany..
    Swerdlow, Anthony
    Inst Canc Res, Div Genet & Epidemiol, London, England.;Inst Canc Res, Div Breast Canc Res, London, England..
    Szabo, Csilla I.
    NHGRI, NIH, Bethesda, MD 20892 USA..
    Tchatchou, Sandrine
    Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada..
    Teixeira, Manuel R.
    Portuguese Oncol Inst, Dept Genet, Oporto, Portugal.;Univ Porto, Biomed Sci Inst ICBAS, Oporto, Portugal..
    Teo, Soo H.
    Canc Res Initiat Fdn, Subang Jaya, Selangor, Malaysia.;Univ Malaya, Med Ctr, Canc Res Inst, Breast Canc Res Unit, Kuala Lumpur, Malaysia..
    Terry, Mary Beth
    Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA..
    Tessier, Daniel C.
    McGill Univ, Montreal, PQ, Canada.;Genome Quebec Innovat Ctr, Montreal, PQ, Canada..
    Teule, Alex
    Catalan Inst Oncol, IDIBELL Bellvitge Biomed Res Inst, Hereditary Canc Program, Genet Counseling Unit, Barcelona, Spain..
    Thomassen, Mads
    Odense Univ Hosp, Dept Clin Genet, Odense C, Denmark..
    Tihomirova, Laima
    Latvian Biomed Res & Study Ctr, Riga, Latvia..
    Tischkowitz, Marc
    McGill Univ, Program Canc Genet, Dept Human Genet, Montreal, PQ, Canada.;McGill Univ, Dept Oncol, Montreal, PQ, Canada.;Univ Cambridge, Sch Med, Cambridge, England..
    Toland, Amanda E.
    Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH USA..
    Tung, Nadine
    Beth Israel Deaconess Med Ctr, Dept Med Oncol, Boston, MA 02215 USA..
    Turnbull, Clare
    Inst Canc Res, Sect Canc Genet, London, England..
    van den Ouweland, Ans M. W.
    Erasmus Univ, Med Ctr, Dept Clin Genet, Rotterdam, Netherlands..
    van Rensburg, Elizabeth J.
    Univ Pretoria, Dept Genet, Pretoria, South Africa..
    ven den Berg, David
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA..
    Vijai, Joseph
    Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, Clin Genet Res Lab, 1275 York Ave, New York, NY 10021 USA.;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA..
    Wang-Gohrke, Shan
    Univ Ulm, Dept Obstet & Gynecol, Ulm, Germany..
    Weitzel, Jeffrey N.
    City Hope Natl Med Ctr, Clin Canc Genet Community Res Network, Clin Canc Genet, Duarte, CA USA..
    Whittemore, Alice S.
    Stanford Univ, Sch Med, Dept Hlth Res & Policy Epidemiol, Stanford, CA 94305 USA.;Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA..
    Winqvist, Robert
    Univ Oulu, Lab Canc Genet & Tumor Biol, Dept Clin Chem, Oulu, Finland.;Univ Oulu, Bioctr Oulu, Oulu, Finland.;Ctr NordLab Oulu, Northern Finland Lab, Lab Canc Genet & Tumor Biol, Oulu, Finland..
    Wong, Tien Y.
    Natl Univ Singapore, Singapore Eye Res Inst, Singapore, Singapore..
    Wu, Anna H.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA..
    Yannoukakos, Drakoulis
    Aristotle Univ Thessaloniki, Sch Med, Papageorgiou Hosp, Dept Med Oncol, Thessaloniki, Greece..
    Yu, Jyh-Cherng
    Natl Taiwan Univ Hosp, Dept Surg, Taipei, Taiwan..
    Pharoah, Paul D. P.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.;Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England..
    Hall, Per
    Univ Laval, Prote Ctr, CHU Quebec Res Ctr, Quebec City, PQ G1K 7P4, Canada.;Univ Laval, Dept Mol Med, Quebec City, PQ G1K 7P4, Canada..
    Chenevix-Trench, Georgia
    QIMR Berghofer Med Res Inst, Dept Genet, Brisbane, Qld, Australia.;Univ Melbourne, Peter MacCallum Canc Inst, Melbourne, Vic, Australia..
    Dunning, Alison M.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England..
    Simard, Jacques
    Univ Laval, Ctr Hosp Univ Quebec Res Ctr, Genom Ctr, Quebec City, PQ, Canada..
    Couch, Fergus J.
    Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA..
    Antoniou, Antonis C.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England..
    Easton, Douglas F.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.;Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England..
    Zheng, Wei
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med, 2525 West End Ave,8th Floor, Nashville, TN 37203 USA..
    Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus2016In: Breast Cancer Research, ISSN 1465-5411, E-ISSN 1465-542X, Vol. 18, article id 64Article in journal (Refereed)
    Abstract [en]

    Background: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. Method: We performed a fine-scale mapping study of a 700 kb region including 441 genotyped and more than 1300 imputed genetic variants in 48,155 cases and 43,612 controls of European descent, 6269 cases and 6624 controls of East Asian descent and 1116 cases and 932 controls of African descent in the Breast Cancer Association Consortium (BCAC; http://bcac.ccge.medschl.cam.ac.uk/), and in 15,252 BRCA1 mutation carriers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Stepwise regression analyses were performed to identify independent association signals. Data from the Encyclopedia of DNA Elements project (ENCODE) and the Cancer Genome Atlas (TCGA) were used for functional annotation. Results: Analysis of data from European descendants found evidence for four independent association signals at 12p11, represented by rs7297051 (odds ratio (OR) = 1.09, 95 % confidence interval (CI) = 1.06-1.12; P = 3 x 10(-9)), rs805510 (OR = 1.08, 95 % CI = 1.04-1.12, P = 2 x 10(-5)), and rs1871152 (OR = 1.04, 95 % CI = 1.02-1.06; P = 2 x 10(-4)) identified in the general populations, and rs113824616 (P = 7 x 10(-5)) identified in the meta-analysis of BCAC ER-negative cases and BRCA1 mutation carriers. SNPs rs7297051, rs805510 and rs113824616 were also associated with breast cancer risk at P < 0.05 in East Asians, but none of the associations were statistically significant in African descendants. Multiple candidate functional variants are located in putative enhancer sequences. Chromatin interaction data suggested that PTHLH was the likely target gene of these enhancers. Of the six variants with the strongest evidence of potential functionality, rs11049453 was statistically significantly associated with the expression of PTHLH and its nearby gene CCDC91 at P < 0.05. Conclusion: This study identified four independent association signals at 12p11 and revealed potentially functional variants, providing additional insights into the underlying biological mechanism(s) for the association observed between variants at 12p11 and breast cancer risk.

  • 246753.
    Zeng, Kailin
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics.
    Convexity theory for term structure equation: an extension to the jump-diffusion case2010Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • 246754.
    Zeng, Lin
    et al.
    Nanjing University.
    Lu, Huayu
    Nanjing University.
    Yi, Shuangwen
    Nanjing University.
    Stevens, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Xu, Zhiwei
    Nanjing University.
    Zhuo, Haixing
    Nanjing University.
    Yu, Kaifeng
    Nanjing University.
    Zhang, Hanzhi
    Long-term Pleistocene aridification and possible linkage to high-latitude forcing: New evidence from grain size and magnetic susceptibility from loess-paleosol record in northeastern China2017In: Catena (Cremlingen. Print), ISSN 0341-8162, E-ISSN 1872-6887, Vol. 154, p. 21-32Article in journal (Refereed)
    Abstract [en]

    Loess deposits are regarded as good indicators of the inception and development of arid and semi-arid climate in central Asia and northern China during the late Cenozoic. In northeastern China extensive loess deposits are found surrounding the Horqin and Otindag sand fields, and they have great potential for reconstructing the long-term aridification history of the region. However, these loess deposits are currently poorly understood. Here, we present a high-resolution magnetic susceptibility (MS) and grain-size record spanning the last 1.0 Ma from a 36.6-m-thick loess-paleosol sequence at Niuyangzigou site (NYZG) in NE China. The grain-size record reveals a long-term drying trend in NE China since ca. 1.0 Ma, punctuated by two significant abrupt drying events at similar to 0.65 Ma and similar to 0.3 Ma. These results demonstrate a process of stepwise intensification of drying in NE China over the past 1 Ma, and lend support to the hypothesis that global ice volume/temperature changes were the major driver of the long-term aridification of Asian dust source areas. However, unlike the widely studied loess deposits on the central Chinese Loess Plateau (CLP), the MS record in paleosol units Sl, S2 and S4 from the NYZG site do not show evidence of enhanced monsoon precipitation resulting from decreased global ice volume and the prolonged episodes of interglaciation after the Mid-Pleistocene Transition evident in the ice volume record. We hypothesize that this may be due to differences in the climatic sensitivity of the MS of Chinese loess deposits on a regional scale, rather than to in regional differences in monsoon intensity.

  • 246755.
    Zeng, Pingling
    et al.
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Alfredsson, Lars
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Klareskog, Lars
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Mullazehi, Mohammed
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Saevarsdottir, Saedis
    Karolinska Inst, Stockholm, Sweden.;Karonlinska Univ Hosp, Stockholm, Sweden..
    Bengtsson, Camilla
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Rönnelid, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Occupational Physical Workload and Development of Anti-Collagen Type II Antibodies in Rheumatoid Arthritis Patients2017In: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, no S10, article id 132Article in journal (Other academic)
  • 246756. Zeng, Qiao-Shi
    et al.
    Ding, Yang
    Mao, Wendy L
    Luo, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science, Materials Theory.
    Blomqvist, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science, Materials Theory.
    Ahuja, Rajeev
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science, Materials Theory.
    Yang, Wenge
    Shu, Jinfu
    Sinogeikin, Stas V
    Meng, Yue
    Brewe, Dale L
    Jiang, Jian-Zhong
    Mao, Ho-Kwang
    Substitutional alloy of Ce and Al2009In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 106, no 8, p. 2515-2518Article in journal (Refereed)
    Abstract [en]

    The formation of substitutional alloys has been restricted to elements with similar atomic radii and electronegativity. Using high-pressure at 298 K, we synthesized a face-centered cubic disordered alloy of highly dissimilar elements (large Ce and small Al atoms) by compressing the Ce(3)Al intermetallic compound >15 GPa or the Ce(3)Al metallic glass >25 GPa. Synchrotron X-ray diffraction, Ce L(3)-edge absorption spectroscopy, and ab initio calculations revealed that the pressure-induced Kondo volume collapse and 4f electron delocalization of Ce reduced the differences between Ce and Al and brought them within the Hume-Rothery (HR) limit for substitutional alloying. The alloy remained after complete release of pressure, which was also accompanied by the transformation of Ce back to its ambient 4f electron localized state and reversal of the Kondo volume collapse, resulting in a non-HR alloy at ambient conditions.

  • 246757. Zeng, R.
    et al.
    Coates, J. R.
    Johnson, G. C.
    Hansen, L.
    Awano, T.
    Kolicheski, A.
    Ivansson, Emma
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Perloski, M.
    Lindblad-Toh, Kerstin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    O'Brien, D. P.
    Guo, J.
    Katz, M. L.
    Johnson, G. S.
    Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy2014In: Journal of Veterinary Internal Medicine, ISSN 0891-6640, E-ISSN 1939-1676, Vol. 28, no 2, p. 515-521Article in journal (Refereed)
    Abstract [en]

    Background Previous reports associated 2 mutant SOD1 alleles (SOD1:c.118A and SOD1:c.52T) with degenerative myelopathy in 6 canine breeds. The distribution of these alleles in other breeds has not been reported. Objective To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. Animals DNA from 33,747 dogs was genotyped at SOD1:c.118, SOD1:c.52, or both. Spinal cord sections from 249 of these dogs were examined. Methods Retrospective analysis of 35,359 previously determined genotypes at SOD1:c.118G>A or SOD1:c.52A>T and prospective survey to update the clinical status of a subset of dogs from which samples were obtained with a relatively low ascertainment bias. Results The SOD1:c.118A allele was found in cross-bred dogs and in 124 different canine breeds whereas the SOD1:c.52T allele was only found in Bernese Mountain Dogs. Most of the dogs with histopathologically confirmed degenerative myelopathy were SOD1:c.118A homozygotes, but 8 dogs with histopathologically confirmed degenerative myelopathy were SOD1:c.118A/G heterozygotes and had no other sequence variants in their SOD1 amino acid coding regions. The updated clinical conditions of dogs from which samples were obtained with a relatively low ascertainment bias suggest that SOD1:c.118A homozygotes are at a much higher risk of developing degenerative myelopathy than are SOD1:c.118A/G heterozygotes. Conclusions and Clinical Importance We conclude that the SOD1:c.118A allele is widespread and common among privately owned dogs whereas the SOD1:c.52T allele is rare and appears to be limited to Bernese Mountain Dogs. We also conclude that breeding to avoid the production of SOD1:c.118A homozygotes is a rational strategy.

  • 246758.
    Zeng, Ruifeng
    et al.
    Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Wenzhou, Peoples R China.;Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China..
    Svensen, Christer H.
    Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Wenzhou, Peoples R China.;Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.;Karolinska Inst, Sect Anesthesiol & Intens Care, Dept Clin Sci & Educ, Stockholm, Sweden.;Univ Texas Med Branch, Dept Anesthesiol, UTMB Hlth, Galveston, TX 77555 USA..
    Li, Husong
    Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Wenzhou, Peoples R China.;Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.;Univ Texas Med Branch, Dept Anesthesiol, UTMB Hlth, Galveston, TX 77555 USA..
    Xu, Ximou
    Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Wenzhou, Peoples R China.;Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China..
    Skoog Svanberg, Agneta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.
    Liu, Huacheng
    Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Wenzhou, Peoples R China.;Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China..
    Li, Yanrong
    Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Wenzhou, Peoples R China.;Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China..
    Shangguan, Wangning
    Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Wenzhou, Peoples R China.;Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China..
    Lian, Qingquan
    Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Wenzhou, Peoples R China.;Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China..
    Can noninvasive hemoglobin measurement reduce the need for preoperative venipuncture in pediatric outpatient surgery?2017In: Pediatric Anaesthesia, ISSN 1155-5645, E-ISSN 1460-9592, Vol. 27, no 11, p. 1131-1135Article in journal (Refereed)
    Abstract [en]

    Background: Noninvasive measurements of hemoglobin in the pediatric perioperative setting could be helpful to avoid venipunctures in children. The present study aims to evaluate this by using a noninvasive device for hemoglobin determination. We compared noninvasively obtained hemoglobin with laboratory hemoglobin concentrations in children during their preoperative assessment.

    Methods: In an observational study, 122 nonanemic children (age 4.21.6years) who were scheduled to undergo different surgical procedures under general anesthesia were included. In their preoperative preparations, single invasive blood samples for laboratory hemoglobin concentrations were routinely taken following hospital policy and compared to simultaneous noninvasive determinations of hemoglobin. A preoperative invasive value 9g/dL would have caused cancelation of surgery and implied further investigations.

    Results: A Bland-Altman plot showed that the average difference between noninvasively obtained hemoglobin and laboratory hemoglobin concentration was -0.44g/dL (bias) with a standard deviation of the mean bias of 1.04g/dL. A hemoglobin error grid showed that the noninvasive device could identify almost all invasive hemoglobin values >9g/dL. In total, there were 4 false-positive values where noninvasively obtained hemoglobin observations were below while the paired invasive values were above 9g/dL.

    Conclusion: The data in this pediatric setting suggest that the device may eliminate the need for venipuncture in nonanemic children.

  • 246759.
    Zeng, Ruixue
    et al.
    Fudan Univ, Sch Microelect, State Key Lab ASIC & Syst, Shanghai 200433, Peoples R China..
    Zhang, Junkai
    Fudan Univ, Sch Microelect, State Key Lab ASIC & Syst, Shanghai 200433, Peoples R China..
    Sun, Cuiling
    Fudan Univ, Sch Microelect, State Key Lab ASIC & Syst, Shanghai 200433, Peoples R China..
    Xu, Ming
    Fudan Univ, Sch Microelect, State Key Lab ASIC & Syst, Shanghai 200433, Peoples R China..
    Zhang, Shi-Li
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Wu, Dongping
    Fudan Univ, Sch Microelect, State Key Lab ASIC & Syst, Shanghai 200433, Peoples R China..
    A reference-less semiconductor ion sensor2018In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 254, p. 102-109Article in journal (Refereed)
    Abstract [en]

    Ion sensing represents a grand research field with tremendous challenges and ample opportunities. A proper operation of ion sensors demands a robust reference electrode (RE), but on-chip integration of a conventional liquid-filled RE is incompatible with semiconductor technology for manufacturing ion-sensitive field-effect transistors as electronic sensors. Here, we demonstrate a reference-less semiconductor ion sensor, RELESIS, that integrates an interdigitated electrode (IDE) with a field-effect transistor. As a constant solution potential is no longer necessary, the use of RELESIS eliminates the need of any RE in ion sensing. The evaluated IDE comprises two intertwined metallic combs, each being covered with a specific sensing layer. One of the combs is connected to the transistor for readout while another is biased with a voltage signal source. Our extensive measurement results with pH sensing confirm that the sensitivity of RELESIS is exclusively determined by the sensitivity difference of the two sensing layers. By eliminating bulky REs, the RELESIS may find myriad ion-sensing applications owing to its miniaturisability, integrability, flexibility and cost advantages.

  • 246760. Zeng, Ruixue
    et al.
    Zhang, Junkai
    Yang, Hui
    Sun, Cuiling
    Xu, Ming
    Zhang, Shi-Li
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Wu, Dongping
    Modelling and Characterization of Novel Reference-Less Semiconductor Ion Sensor for pH Sensing2019In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 281, p. 60-71Article in journal (Refereed)
    Abstract [en]

    A SPICE macromodel is developed for a novel reference-less semiconductor ion sensor (RELESIS), which has been proposed to eliminate the use of reference electrode in the field effect based sensor detection. The working principle of the RELESIS, previously validated by a prototype device via pH sensing, is featured by non-constant bulk solution potential, which distincts itself from any conventional ion sensitive field effect transistor. Simulations are performed here using the macromodel and the results fit well with the experimental data. The proposed SPICE macromodel can be used to predict the behavior of the RELESIS and carry out performance optimizations for the RELESIS to be used in various applications.

  • 246761.
    Zeng, Shuangshuang
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Wen, Chenyu
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Solomon, Paul
    Zhang, Shi-Li
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Zhang, Zhen
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Rectification of protein translocation in truncated-pyramidal nanopores caused by the formation of electroosmotic vortex2019In: Nature Nanotechnology, ISSN 1748-3387, E-ISSN 1748-3395Article in journal (Refereed)
  • 246762.
    Zeng, Shuangshuang
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Wen, Chenyu
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Zhang, Shi-Li
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Zhang, Zhen
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Single molecule detection via solid state carbon nanopore2018Conference paper (Other academic)
    Abstract [en]

    Single molecule detection is of vital importance for fundamental biotechnology research and practical applications. Among the numerous single molecule detection techniques, solid-state nanopores have been developed as single molecule sensors for the investigation of unlabeled biopolymers such as DNA, RNA and protein owing to their robustness, pore size controllability and tunability of physical/chemical properties. The most commonly used method today to form ultra-small nanopores relies on using focused high energy electron beams on a transmission electron microscope (TEM). However, the sophisticated operation of TEM, high cost and low throughput limit its extensive applications. In this work, we start with electron beam lithography combined with reactive ion etching to massively prefabricate nanopores with relatively large size in free-standing silicon nitride membranes. Then, electron beam irradiation is used to deposit carbon with a conventional scanning electron microscope so as to reduce the size of prefabricated pores. This process leads to the controllable formation of solid-state carbon nanopores sub-30 nm in diameter. We subsequently use the carbon nanopores to study translocation of λ-DNA as a demonstration of the capability of such carbon nanopores. By tuning bias voltage, the translocation events show regular changes in amplitude, dwell time and appearance frequency. With this advanced nanopore platform, detection of single DNA molecules is achieved with a high signal-to-noise ratio of ~6.

  • 246763.
    Zeng, Wei
    et al.
    Wuhan Univ, State Key Lab Water Resources & Hydropower Engn S, Wuhan 430072, Peoples R China..
    Yang, Jiandong
    Wuhan Univ, State Key Lab Water Resources & Hydropower Engn S, Wuhan 430072, Peoples R China..
    Tang, Renbo
    Wuhan Univ, State Key Lab Water Resources & Hydropower Engn S, Wuhan 430072, Peoples R China..
    Yang, Weijia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Extreme water-hammer pressure during one-after-another load shedding in pumped-storage stations2016In: Renewable energy, ISSN 0960-1481, E-ISSN 1879-0682, Vol. 99, p. 35-44Article in journal (Refereed)
    Abstract [en]

    The intermittent and unpredictable wind and solar power leads to the frequent transient processing of pumped-storage stations, increasing the probability of load shedding. When one turbine sheds its load, the other turbines in the same hydraulic unit become overloaded and may shed their loads, which is referred to as a "one-after-another (OAA)" load-shedding process. An extremely high water-hammer pressure (WHP), namely, high spiral case pressure (SCP) or low draft tube pressure (DTP), may arise in this case, directly threatening the safety of the PSS. The objective of this study was to theoretically determine the hydraulic connections between the turbines and reveal the mechanism of the rapid rise in the WHP under the OAA load-shedding conditions. Theoretical derivations inferred that the drastic pressure changes in a trail shedding turbine (TST) are caused by the hydraulic connection with the lead shedding turbine (LST) in the S region. Furthermore, numerical simulations and model experiments were performed for the OAA load-shedding process, which confirmed the validity of the theoretical analysis. Finally, an analysis was conducted on the distribution of the water inertia in the upstream and downstream branch pipes, and engineering measures were proposed to guarantee the safe operation of PSS systems.

  • 246764.
    Zeng, Wei
    et al.
    Wuhan Univ, State Key Lab Water Resources & Hydropower Engn S, Wuhan 430072, Peoples R China..
    Yang, Jiandong
    Wuhan Univ, State Key Lab Water Resources & Hydropower Engn S, Wuhan 430072, Peoples R China..
    Yang, Weijia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Instability analysis of pumped-storage stations under no-load conditions using a parameter-varying model2016In: Renewable energy, ISSN 0960-1481, E-ISSN 1879-0682, Vol. 90, p. 420-429Article in journal (Refereed)
    Abstract [en]

    The S-shaped characteristics of a pump turbine make its rotational speed unstable when it starts up under no-load conditions with low head, affecting its ability to connect to the grid. Although advanced strategies for controlling the speed governor can alleviate this problem, they cannot fundamentally resolve the internal mechanisms that cause difficulties with a grid connection. Therefore, this study set out to theoretically explore the root cause of the instability and the dominant factors influencing it. A correlation fitting process was used to simplify the transcendental function for the pipe flow in elastic mode into a high-precision and low-order linear equation. Next, a detailed study of the two key factors affecting system stability (pump turbine S-shaped characteristics and water elasticity) was carried out based on the system model, and a comprehensive parameter that reflects the no-load characteristics was extracted. Furthermore, the Laplace transform and inverse transform decomposition were used to obtain a mathematical expression for the no-load oscillation in order to analyze the oscillation characteristics. Finally, simulations of no-load oscillations under various heads were performed to further validate the accuracy of the extracted comprehensive parameter for the no-load stability.

  • 246765. Zeng, Wen
    et al.
    Ma, Ming-Guo
    Zhu, Jie-Fang
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Cao, Shao-Wen
    Development and Fabrication of Advanced Materials for Energy and Environment Applications2013In: Journal of Nanomaterials, ISSN 1687-4110, E-ISSN 1687-4129, p. 279309-Article in journal (Other academic)
  • 246766.
    Zeng X., Thibblin A.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Competing base-promoted E2 and E1 reactions of an acidic tertiary substrate2002In: J. Chem. Soc., Perkin Trans 2, p. 1352-Article in journal (Refereed)
  • 246767.
    Zeng, XF
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Thibblin, A
    Competing solvolytic elimination and substitution reactions via very short-lived ion-pair intermediates2001In: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, ISSN 1472-779X, no 9, p. 1600-1607Article in journal (Refereed)
    Abstract [en]

    The solvolysis of 9-methyl-9-(2-X-2-propyl)fluorene (X = Cl, Br, or OOCCF3) (1-X) in aqueous acetonitrile or aqueous 1,1,1-trifluoroethanol (TFE) yields the alkene, 9-methyl-9-(propen-2-yl)fluorene (2), and the alcohol, 9-methyl-9-(2-hydroxy-2-propyl)fluo

  • 246768.
    Zeng, Xiaofeng
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Mechanisms for Solvolytic Elimination and Substitution Reactions Involving Short-lived Carbocation Intermediates2002Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Solvolysis reactions of a range of tertiary substrates in largely aqueous solvents were studied in such respects as β-deuterium kinetic isotope effects, linear free energy relationships and stereochemistry.

    Solvolysis of the fluorene derivatives 9-methyl–9-(2´-X-2´-propyl)fluorene (1-X, X = Cl, Br, OOCCF3) involves a very short-lived carbocation intermediate. The fraction of alkene is increased by addition of general bases, which can be expressed by a Brφnsted parameter β = 0.07. The kinetic deuterium isotope effects vary with solvent composition in a way which is not consistent with a common carbocation intermediate which has time to choose between dehydronation and addition of a solvent water molecule.

    In the absence of bases, the reaction of 4-chloro-4-(4´-nitrophenyl)pentan-2-one (2-Cl) proceeds through a short-lived carbocation intermediate yielding 4-(4´-nitrophenyl)-2-oxopent-4-ene (2-t-ne)as the main elimination product. Addition of acetate ion and other weak bases results in the base-promoted E2 (or E1cb) reaction to give (E)-4-(4´-nitrophenyl)-2-oxopent-3-ene (2-E-ne) and (Z)-4-(4´-nitrophenyl)-2-oxopent-3-ene(2-Z-ne). There is no evidence for a water-promoted E2 (or E1cb) reaction.

    The stereochemistry studies of elimination from (R,S and S,R)-[1-(3´-fluoro)phenyl-2-methyl]cyclopentyl-p-nitrobenzoate (3-PNB) and its (R,R and S,S)isomer 3´-PNB and (R,S and S,R)-[1´-(3´´-fluoro)phenyl-2´-methylcyclopentyl]-2,2,2-trifluoroacetate(3-OOCCF3) exclude the concerted pericyclic elimination mechanism for formation of the alkene 1-(3´-fluoro)phenyl-2-methylcyclopentene(3-m-ne). The effects of added thiocyanate ion and halide ions on the solvolysis reaction are discussed.

    Mass spectrometry analysis showed complete incorporation of the labeled oxygen from solvent water into the product 2-hydroxy-2-phenyl-3-butene (4-OH), confirming that it is the tertiary carbon-oxygen bond that is broken in the acid-catalyzed solvolysis of 2-methoxy-2-phenyl-3-butene (4-OMe). The mechanism for the dominant formation of the less stable 4-OH is discussed.

  • 246769.
    Zeng, Yang
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Finite Element Methods for Microelectromechanical Systems2009Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The stationary Joule heating problem is a crucial multiphysical problem for many microelectromechanical (MEMS) applications. In our paper, we derive a finite element method for this problem and introduce iterative solution-techniques to compute the numerical simulation. Further we construct an adaptive algorithm for mesh refinement based on a posteriori error estimation.Finally, we present two numerical tests: convergences analysis of different iterative methods for distinct materials which are classified by electrical conductivities, and a test of the new adaptive refinement algorithm. All the numerical implementations have been done in MATLAB.

  • 246770.
    Zeng, Zhe
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    THE RELATIONSHIP BETWEEN MACROECONOMIC VARIABLES AND THE CHINESE STOCK MARKET-AN APPLICATION OF VECTOR ERROR CORRECTION MODEL2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Using Johansen's vector error correction model, this paper investigates the long-term equilibrium between stock price and six selected macroeconomic variables in China. On testing different VECM models, we find that there is no long-term equilibrium between stock price and 6 macroeconomic variables, although there may exist long-term equilibrium among macroeconomic variables themselves. However, by applying impulse responses plots, we find that industrial production, exchange rate and interest rate do have effects on stock price that are consistent with economic hypotheses. This indicates that Chinese stock market does reflect economic situation to some extent, so it can be considered as an indicator of the real economy.

  • 246771.
    Zenk, Kajsa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Varumärkesanvändning och gränsdragningen mot icke-användning: Särskilt i ljuset av EU-domstolens avgörande i Mitsubishi mot Duma2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • 246772. Zenkert, Patrik
    Acceptance testing a complete system contra a single-unit system2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 246773.
    Zenobi, Diego
    et al.
    Universidad de Buenos Aires, Argentina.
    Baez Ullberg, SusannCRISMART ISSL Försvarshögskolan.Camargo da Silva, TelmaUniversidade Federal de Goiás.
    Traces: Mémoires et politiques des désastres en Amérique Latine2016Collection (editor) (Other academic)
    Abstract [fr]

    Ces quatre études s'inscrivent dans le champ de l'anthropologie des désastres : en 1987, au Brésil, des habitants sont contaminés au césium 137 ; le 29 avril 2003, une inondation catastrophique se produit dans la ville de Santa Fe ; le 3 décembre 2004, à Buenos Aires, un incendie durant un concert coûte la vie à 194 jeunes ; un dépotoir, à Buenos Aires, est le lieu de passage vers le cirujeo, devenir ramasseur d'ordures pour survivre. Ces études posent la question de la mémoire : comment l'organiser et la garder ?

  • 246774.
    Zens, Patrick Stephan
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Aerosol Input and Snow Accumulation Rates on the Northern Greenland Ice Sheet: Reconstructed by means of Continuous Flow Analysis (CFA) of 6 shallow firn cores2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Ice, firn and snow cores from the Greenland ice sheet offer a unique opportunity to reconstruct past climate conditions. These can be analyzed with continuous flow analysis (CFA) in order to acquire proxy information about ancient atmospheric aerosol concentrations, snow accumulation rates or temperature variations, atmospheric composition, solar activity as well as volcanism and biological activity.

    This project deals with high-resolution CFA applied on six shallow firn cores (A1-A6) from Northern Greenland taken during a 456 km long traverse from the deep ice core drilling sites NEEM to that called EGRIP. The practical part included CFA measurements by means of fluorescence spectroscopy for obtaining NH4+, Ca2+ and H2O2, absorption spectroscopy for H+, an ion selective electrode (ISE) for Na+ as well as insoluble dust and water electrolytic conductivity measurements. The analytical part consisted of calibrations of the measurements, the reconstruction of the depth scale of the snow/firn cores and defining annual layers using H2O2. Field density measurements and the annual layer thicknesses were used to identify annual mean snow accumulation rates.

    These high-resolution firn records allowed determining accurate monthly maximum and minimum aerosol concentrations in order to evaluate seasonal deposition patterns and validate the applied dating method. The reconstructed ages ranged from 17 ± 1 to 54 ± 2 years along a northwest-southeast gradient. Statistical tests resulted merely for H2O2 in correlations between the three western cores, probably explained by the dating method, which forces the annual summer maxima and winter minima of H2O2 to correlate. Trend analysis resulted in no significant changes over time except for the conductivity measurements of the two longest/oldest firn cores. This is associated with decreasing acidifying anthropogenic sulfur emissions since the 1970’s.

    Annual mean snow accumulation rates ranged from 0.235 ± 0.061 m w.eq.a-1 in the very west of the traverse to 0.103 ± 0.036 m w.eq.a-1 centered on the Greenland ice-divide. Correlation maps derived from ERA-Interim reanalysis were used, to indicate potential correlations between the six firn cores. Similar to the results for H2O2, a significant correlation could only be determined between the three westernmost cores. A significant increasing trend of snow accumulation since the 1960’s was detectable for core A6 in the ice sheet’s interior.

    These traverse cores represent point measurements in a large, highly variable and poorly studied region of Northern Greenland. Hence, more extensive investigations are essential to reduce the uncertainty, cancel out influencing snow surface processes and improve the representativeness of isolated locations. Conclusively, the produced results update impurity and accumulation datasets until 2015, determine trends and provide input for surface mass balance estimations and ground truth data for satellite observations. 

  • 246775.
    Zentner, Christian
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    ExpoMate: A Mobile Assistant for Location -Based Services and Indoor Navigation2016Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    Companies, that aim to expand their customer base, will find it important to advertisenew products at exhibitions. However, the huge, international exhibitions that arecommon nowadays, are a hassle for visitors, vendors and organisers likewise. Due tothe size, a lot of information needs to be published for the visitors, so that they canfind their way across the exhibition area, locate the stands they are interested in andexchange their business information. In a digital age, where almost every personowns at least one mobile device, all this information is still distributed as printedhandouts and business cards, which wastes a lot of paper and produces unnecessarytrash.This thesis report describes the development of a mobile application, that replacesthe handouts in a digital, non-polluting way, and also succeeds the usefulness of itspaper counterpart. This application allows its users to browse through generalexhibition information and categorised lists of all the stands on the area. The use ofiBeacons enables location-based features that help to locate the user, as well as standsof interest, and can provide an overview of the current surroundings at any time.Additionally, navigational features assist the visitors in finding their way to stands theywant to visit.By using an application like this, a lot of work and money can be saved for organisingsuch an event. The design and priting of exhibition information, including the list ofall companies and their stands, and the obligatory exhibition map, would not benecessary any more. Also, the mobile application offers some features to the visitorsthat allows them to save time, which also increases the throughput of the exhibition.

  • 246776.
    Zepeda, Vanessa K.
    et al.
    Univ Hawaii Manoa, Dept Microbiol, Honolulu, HI 96822 USA..
    Busse, Hans-Juergen
    Vet Med Univ Wien, Inst Mikrobiol, A-1210 Vienna, Austria..
    Golke, Jan
    Vet Med Univ Wien, Inst Mikrobiol, A-1210 Vienna, Austria..
    Saw, Jimmy H. W.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution.
    Alam, Maqsudul
    Univ Hawaii Manoa, Dept Microbiol, Honolulu, HI 96822 USA..
    Donachie, Stuart P.
    Univ Hawaii Manoa, Dept Microbiol, Honolulu, HI 96822 USA..
    Terasakiispira papahanaumokuakeensis gen. nov., sp nov., a gammaproteobacterium from Pearl and Hermes Atoll, Northwestern Hawaiian Islands2015In: International Journal of Systematic and Evolutionary Microbiology, ISSN 1466-5026, E-ISSN 1466-5034, Vol. 65, p. 3609-3617Article in journal (Refereed)
    Abstract [en]

    A Gram-negative, helical bacterium designated PH27A(T) was cultivated from an anchialine pool on Pearl and Hermes Atoll, Northwestern Hawaiian Islands. The obligately halophilic strain was motile by bipolar tufts of flagella and grew optimally at pH 7, and microaerobically or aerobically. Closest neighbours based on 16S rRNA gene nucleotide sequence identity are Marinospirillum celere v1c_Sn-red(T) (93.31 %) and M. alkaliphilum Z4(T) (92.10 %) in the family Oceanospirillaceae, class Gammaproteobacteria. PH27A(T) is distinguished phenotypically from members of the genus Marinospirillum by its hydrolysis of gelatin, the absence of growth in media containing <= 1 % (w/v) NaCl and the ranges of temperature (12-40 degrees C) and pH (5-8) for growth. The major compound ubiquinone Q-9 distinguishes the quinone system of strain PH27A(T) from those in members of the genus Marinospirillum and other members of the Oceanospirillaceae, in which the major quinone is Q-8. Major polar lipids in PH27A(T) were phosphatidylethanolamine and phosphatidylglycerol, with moderate amounts of diphosphatidylglycerol and phosphatidylserine. Spermidine and cadaverine dominated the polyamine pattern; large proportions of cadaverine have not been reported in members of the genus Marinospirillum. Genotypic and chemotaxonomic data show that PH27A(T) does not belong in the genus Marinospirillum or other genera of the family Oceanospirillaceae or the Halomonadaceae. We propose a new genus, Terasakiispira gen. nov., be created to accommodate Terasakiispira papahanaumokuakeensis gen. nov., sp. nov. as the type species, with PH27A(T) (=ATCC BAA-995(T)=DSM 16455(T)=DSM 23961(T)) as the type strain.

  • 246777. Zerbi, F. M.
    et al.
    Bouchy, F.
    Fynbo, J.
    Maiolino, R.
    Piskunov, Nikolai
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy.
    Rebolo Lopez, R.
    Santos, N.
    Strassmeier, K.
    Udry, S.
    Vanzi, L.
    Riva, M.
    Basden, A.
    Boisse, I.
    Bonfils, X.
    Buscher, D.
    Cabral, A.
    Dimarcantonio, P.
    Di Varano, I.
    Henry, D.
    Monteiro, M.
    Morris, T.
    Murray, G.
    Oliva, E.
    Parry, I.
    Pepe, F.
    Quirrenbach, A.
    Rasilla, J. L.
    Rees, P.
    Stempels, Eric
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy.
    Valenziano, L.
    Wells, M.
    Wildi, F.
    Origlia, L.
    Allende Prieto, C.
    Chiavassa, A.
    Cristiani, S.
    Figueira, P.
    Gustafsson, Bengt
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy.
    Hatzes, A.
    Haehnelt, M.
    Heng, K.
    Israelian, G.
    Kochukhov, Oleg
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy.
    Lovis, C.
    Marconi, A.
    Martins, C. J. A. P.
    Noterdaeme, P.
    Petitjean, P.
    Puzia, T.
    Queloz, D.
    Reiners, A.
    Zoccali, M.
    HIRES: The High Resolution Spectrograph for E-ELT2014In: Ground-based and Airborne Instrumentation for Astronomy V / [ed] Suzanne K. Ramsay, Ian S. McLean, Hideki Takami, 2014, Vol. 9147, article id 914723Conference paper (Refereed)
    Abstract [en]

    The current instrumentation plan for the E-ELT foresees a High Resolution Spectrograph conventionally indicated as HIRES. Shaped on the study of extra-solar planet atmospheres, Pop-III stars and fundamental physical constants, HIRES is intended to embed observing modes at high-resolution (up to R=150000) and large spectral range (from the blue limit to the K band) useful for a large suite of science cases that can exclusively be tackled by the E-ELT. We present in this paper the solution for HIRES envisaged by the "HIRES initiative", the international collaboration established in 2013 to pursue a HIRES on E-ELT.

  • 246778.
    Zere, Fethy
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Sadr, Padra
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Företagisering av vården2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med denna uppsats har varit att undersöka vilka specifika konsekvenser företagisering har haft på vården samt få en nyanserad bild av företagisering. För att undersöka detta valde vi Akademiska sjukhuset i Uppsala som studieobjekt. Kvalitativ metod användes för att samla in empirisk data. Ostrukturerade intervjuer med personal från olika delar av en sjukhus organisation har utförts. Empirin som vi har fått fram har analyserats med hjälp av den teoretiska referensramen vilket bestod bland annat av olika former av företagisering samt kritik mot New Public Management. Antaganden om idéer från den privata sektorn kan implementeras på organisationer som sjukhus vars syfte inte är att gå med vinst skapar en viss obalans i strukturen på verksamheten.

  • 246779.
    Zerhoun, Samira
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature, Rhetoric.
    En dåre, en sovhjärna och en vaken: En analys av den politiska fiktionen i Fredrik Reinfeldts Det sovande folket2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 246780. Zernii, Evgenii Yu
    et al.
    Tikhomirova, Natalia K.
    Hellman, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Philippov, Pavel P.
    Senin, Ivan I.
    Annexins in bovine photoreceptors2004In: Annexins, Vol. 1, no 1, p. 44-50Article in journal (Refereed)
  • 246781.
    Zernov, Alexei
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Nuclear and Particle Physics.
    Electronic instrumentation for multichannel scintillation detector systems.1997Licentiate thesis, monograph (Other scientific)
  • 246782.
    Zernov, NN
    et al.
    Uppsala University.
    Lundborg, B
    Uppsala University.
    An integral representation of the wave field in inhomogeneous media in terms of diffracting component waves1996In: RADIO SCIENCE, Vol. 31, no 1, p. 67-80Article in journal (Other scientific)
    Abstract [en]

    This paper gives a review of the advantages offered by an integral representation using diffracting component waves in solving wave propagation problems, deterministic as well as stochastic, in multiscale media. The component waves are constructed in such

  • 246783.
    ZERNOV, NN
    et al.
    Uppsala University.
    LUNDBORG, B
    Uppsala University.
    THE INFLUENCE OF IONOSPHERIC ELECTRON-DENSITY FLUCTUATIONS ON HF PULSE-PROPAGATION1995In: JOURNAL OF ATMOSPHERIC AND TERRESTRIAL PHYSICS, ISSN 0021-9169, Vol. 57, no 1, p. 65-73Article in journal (Other scientific)
    Abstract [en]

    The influence of electron density fluctuations on the dispersive properties of the ionosphere is investigated in the forward scattering approximation by means of a generalized Rytov's method. The analysis is performed under the simplifying assumptions of

  • 246784.
    Zerpe, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Barn och ungdomar med fetma: Samband mellan upplevt problem och motivation till förändring2012Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    SUMMARY

    Aim: The aim of the study was to investigate whether there was any correlation between age, iso-BMI, experienced problem of overweight and motivation for change in the children being treated at the pediatric obesity clinical unit. Method: The design was a cross sectional study with quantitative data. The material is a part of the questionnaire that the children and their parents filled out before their first visit at the obesity unit and iso-BMI was collected from hospital records. SPSS was used for the statistical analysis. The study included 118 children; 54 girls and 64 boys. Results: The study showed that 94.4% of girls and 76.6% of boys felt that their obesity was a problem. There was no correlation between iso-BMI and experienced problem of the overweight. In both groups a negative correlation was found between age and how big the problem was seen. Boys who experienced their overweight as a minor problem had a higher confidence in their ability to act against their overweight compared to boys who experienced their overweight as a bigger problem. The results also showed that the children who thought highly of their ability to act against their overweight also were more ready to act. Conclusion: A majority of the children who have contact with the pediatric obesity clinical unit feel that their obesity is a problem and there is a correlation between the child's age and how big the problem is perceived. Overweight and obesity in children and adolescents is a major problem in our society and further studies and development of treatment is of great importance.

  • 246785.
    Zerpe, Petter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of ALM.
    Demokrati vid sidan av kärnan: En studie av folkbibliotekens programverksamheter utifrån ett demokratiperspektiv2010Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    In this master thesis, I investigate four Public Librarys´ program activities. The purpose is to explore what the library program activities contribute to as a part of a well functioning democracy. The theoretical points, I have brought from political science. I assume three different ideals of democracy; electoral democracy, participation democracy and deliberative democracy. All have different views on what can be characterized by a well-functioning democracy.

    My empirical material consists of library program guides, the libraries´ target documents and interviews with staff at the libraries who work with or have overall responsibility for program activities in their respective libraries. The surveyed libraries was Stockholm city library, Sollentuna library, Uppsala city library and Gävle city library.

    My analysis shows that the librarys´ program activities contribute to a functioning democracy based on aspects of each discussed democratic ideals. The result of the interviews in the paper shows a deliberative democratic approach. The informants discuss and emphasise the library as a natural and free meeting place where everyone has access to debate, discuss and highlight their views.

  • 246786.
    Zerpe, Petter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Musicology.
    I skuggan av betongen.: En analys av social identitet i tre svenska hiphopartisters texter.2005Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    ABSTRACT

    Petter Zerpe: I skuggan av betongen. En analys av social identitet i tre svenska hiphopartisters texter. Uppsala universitet: Institutionen för musikvetenskap. C-uppsats, 2005.

    Denna uppsats har syftat till att belysa hur social identitet skildras i svensk hiphop. Utifrån textanalyser med fokus på etnicitet och kön ämnade jag att undersöka vilken identitet som skildrades i texterna. 

    Jag har funnit att invandrarskapet kan ses som den primära identiteten i texterna hos Latin Kings och Ken. I sina texter visar de sin tillhörighet då de på olika sätt använder bilder och uttryck som förknippas med invandrarskap och förtryck. Latin Kings talar om "svartskallar" och Ken använder ordet slav om låtens berättar-jag. I Fevens texter är däremot inte etnicitet den främsta grunden i identitetsskapandet, utan könet är mer betydande.

     En del av den identitet som artisternas gestaltar hör ihop med en nationalistisk känsla för förorten. Den förortsnationalistiska uppfattningen uttrycks i motsats till det "svenska livet" som innehållslöst och torrt. Den kommer också till uttryck dels som fokusering på det förortens goda sidor med mångkultur, liv och rörelse, dels genom en romantisering och ett försvar av det "hårda livet" i förorten och dess destruktiva sidor som våld, kriminalitet och droger. De använder sig också av nationalistisk symbolik, där kvinnokroppen symboliserar nationen.

     Den egna gruppen eller gänget är mycket väsentlig för identiteten på samma sätt som förorten. Detta kan förklaras av teorin om ett "matrilokalt universum" utan närvarande fäder. Gruppen skapas således för att frigörelse från modern ska bli möjlig. Men modern upphör aldrig att vara väldigt viktig, vilket visar sig i amerikanska svordomar och förolämpningar. Dessa visar sig också inom den svenska hiphopen, där både svordomar och hyllningar förekommer. 

  • 246787.
    Zerzour, Nora
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Tengnér, Ellica
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Att vara blyg i en värld som premierar social utåtriktning: En kvalitativ intervjustudie om unga vuxnas upplevelse och hantering av blyghet2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Blyghet har sedan länge ansetts vara ett statiskt personlighetsdrag som bör botas. I och med den senare socialpsykologiska forskningen inom området har en alltmer mångfacetterad bild etablerats som betonar de interaktionella processerna bakom fenomenet. Eftersom att den tidigare forskningen främst har studerat barn och ungdomar visade sig ämnet vara relativt outforskat vad gäller unga vuxna och deras relation till blyghet. Syftet med uppsatsen tar avstamp i den socialpsykologiska uppfattningen av vad blyghet är och syftar därmed till att skildra hur blyga unga vuxna upplever sin blyghet och bemöts i en värld som premierar social utåtriktning. Kring detta syfte har följande frågeställningar formulerats; Hur formas upplevelsen av blyghet i mellanmänskliga relationer och hur påverkar samhällets normer unga vuxnas upplevelser samt hantering av blyghet? Empirin består av data från kvalitativa semistrukturerade intervjuer, vilka skapades och tolkades med hjälp av en fenomenologisk ansats. Vidare har resultatet analyserats mer ingående med analytiska verktyg från framstående teoretiker inom symbolisk interaktionism. Dessa var Anthony Giddens, Herbert Blumer, Erving Goffman, Arlie Russell Hochschild, George Herbert Mead samt Charles Horton Cooley. Resultatet visar att samhällets värderingar, normer och ideal har en inverkan på unga vuxnas hantering av blyghet, dess sociala samspel med andra samt den allmänna synen och acceptansen gentemot blyghet. Samtliga av dessa aspekter visar sig i sin tur påverka upplevelsen av blyghet och påvisar hur blygheten skapas i mellanmänskliga relationer. Nytillkomna fynd inom ämnesområdet kom att bli maktförhållanden och kulturella skillnader. Utöver detta presenterar studien flera positiva aspekter av blyghet vilka bidrar till ett förnyat meningsskapande av ämnet.

  • 246788.
    Zethelius, B
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Byberg, L
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Hales, CN
    Lithell, H
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Berne, C
    Proinsulin and acute insulin response independently predict Type 2diabetes mellitus in men-report from 27 years of follow-up study.2003In: Diabetologia, Vol. 46, p. 20-Article in journal (Refereed)
  • 246789.
    Zethelius, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Fetma och diabetes2009In: Fetma - del 1: medicinsk behandling och kognitiv beteendeterapi / [ed] Edlund K, Zethelius B, Lund: Studentlitteratur , 2009, 1, p. 65-85Chapter in book (Other academic)
  • 246790.
    Zethelius, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Kapitel 11: Fetma och övervikt2009In: Diabetes / [ed] Carl-David Agardh, Christian Berne, Stockholm: Liber , 2009, 4. uppl., p. 114-126Chapter in book (Other (popular science, discussion, etc.))
  • 246791.
    Zethelius, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Proinsulin and Insulin Sensitivity as Predictors of Type 2 Diabetes Mellitus and Coronary Heart Disease: Clinical Epidemiological Studies with up to 27 Years of Follow-Up2002Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Defects in insulin secretion and insulin action are the major abnormalities in the development of Type 2 diabetes. Hyperinsulinemia is a risk marker for Type 2 diabetes and according to some, but not in all studies also for coronary heart disease (CHD). Conventional insulin assays measure immunoreactive insulin including proinsulin-like molecules.

    Proinsulin and insulin measured by specific methods, insulin sensitivity measured by the euglycemic insulin clamp and early insulin response after a glucose challenge give more detailed information and may be better estimates of true risk for Type 2 diabetes and CHD.

    This study examined relationships between proinsulin, insulin, insulin secretion and insulin sensitivity for the development of Type 2 diabetes and CHD. The investigation of the prognostic significance of proinsulin and insulin for the development of Type 2 diabetes and CHD was performed in prospective studies of 50-year and 70-year-old men in a population-based cohort. The results indicated, that increased proinsulin concentrations, was a marker of increased risk for Type 2 diabetes independent of measurements of insulin secretion and insulin sensitivity whereas insulin was not. Proinsulin was shown to be a predictor for CHD mortality and morbidity, respectively, independent of conventional risk factors, whereas insulin was not. Insulin sensitivity measured by the gold standard euglycemic insulin clamp at age 70 was a predictor of CHD morbidity, independently of established risk factors.

    In summary, these data provide evidence that an increased concentration of proinsulin and not an elevated plasma insulin level per se, that constitutes the association with Type 2 diabetes and CHD and that insulin resistance per se, is associated with CHD risk.

  • 246792.
    Zethelius, Björn
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Proinsulin and Insulin Sensitivity as Predictors of Type 2 Diabetes Mellitus and Coronary Heart Disease. Clinical Epidemiological Studies with up to 27 years of Follow-up.Dissertation2003In: Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1217.Book (Other scientific)
  • 246793.
    Zethelius, Björn
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Berglund, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Hänni, Arvo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Berne, Christian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    The interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose: report from a 20-year follow-up in the Uppsala Longitudinal Study of Adult Men - ULSAM2008In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 113, no 2, p. 117-130Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Impaired acute insulin response (AIR) and insulin resistance (IR) are characteristics of Type 2 diabetes (T2DM). The aim was to develop risk models for T2DM and impaired fasting glucose (IFG), reflecting estimates both of AIR and IR, and of their interaction, as predictors over 20 years of follow-up. METHODS: We developed predictive models using hierarchic multiple regression analyses in a population-based cohort of 1227 men with normal fasting blood glucose at baseline (1970-73) and were reinvestigated after 10 and after 20 years. Using IVGTT-variables correlated either to AIR or to IR, separate models were developed. Combined models were also estimated from which prediction scores, representing individual risk, were calculated. RESULTS: In combined models, interaction between prediction scores reflecting AIR and IR predicted T2DM and IFG. Lowest tertile of AIR and the highest tertile of IR showed a relative risk (RR) of 15.3 (95%-CI=5.58-41.84) for T2DM compared to the contrast group (high AIR and low IR). Corresponding RR for IFG was 13.23 (95%-CI=6.53-26.78). C-statistic increased from 0.76 to 0.79 (p=0.018) for T2DM and from 0.77 to 0.80 for IFG (p=0.062) taking interaction into account. Main effects of lowest tertile of AIR and highest tertile of IR versus best were: RR for T2DM, 8.80 (95%-CI=4.25-18.21) and 6.31 (95%-CI=3.26-12.21); for IFG, 9.07, (95%-CI=5.38-15.29) and 4.49 (95%-CI=2.98-6-76). CONCLUSION: The interaction between low AIR and high IR revealed a high relative risk for T2DM or IFG reflecting the interplay between these factors over long time on worsening glucose tolerance and development of manifest disease.

  • 246794.
    Zethelius, Björn
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Berglund, Lars
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Basu, Samar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Venge, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Arnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Use of multiple biomarkers to improve the prediction of death from cardiovascular causes2008In: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 358, no 20, p. 2107-2116Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The incremental usefulness of adding multiple biomarkers from different disease pathways for predicting the risk of death from cardiovascular causes has not, to our knowledge, been evaluated among the elderly. METHODS: We used data from the Uppsala Longitudinal Study of Adult Men (ULSAM), a community-based cohort of elderly men, to investigate whether a combination of biomarkers that reflect myocardial cell damage, left ventricular dysfunction, renal failure, and inflammation (troponin I, N-terminal pro-brain natriuretic peptide, cystatin C, and C-reactive protein, respectively) improved the risk stratification of a person beyond an assessment that was based on the established risk factors for cardiovascular disease (age, systolic blood pressure, use or nonuse of antihypertensive treatment, total cholesterol, high-density lipoprotein cholesterol, use or nonuse of lipid-lowering treatment, presence or absence of diabetes, smoking status, and body-mass index). RESULTS: During follow-up (median, 10.0 years), 315 of the 1135 participants in our study (mean age, 71 years at baseline) died; 136 deaths were the result of cardiovascular disease. In Cox proportional-hazards models adjusted for established risk factors, all of the biomarkers significantly predicted the risk of death from cardiovascular causes. The C statistic increased significantly when the four biomarkers were incorporated into a model with established risk factors, both in the whole cohort (C statistic with biomarkers vs. without biomarkers, 0.766 vs. 0.664; P<0.001) and in the group of 661 participants who did not have cardiovascular disease at baseline (0.748 vs. 0.688, P=0.03). The improvement in risk assessment remained strong when it was estimated by other statistical measures of model discrimination, calibration, and global fit. CONCLUSIONS: Our data suggest that in elderly men with or without prevalent cardiovascular disease, the simultaneous addition of several biomarkers of cardiovascular and renal abnormalities substantially improves the risk stratification for death from cardiovascular causes beyond that of a model that is based only on established risk factors.

  • 246795. Zethelius, Björn
    et al.
    Byberg, Liisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Hales, C. Nicholas
    Lithell, Hans
    Berne, Christian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Proinsulin is an independent predictor of coronary heart disease: Report from a 27-year follow-up study2002In: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 105, no 18, p. 2153-2158Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Some, but not all, studies have reported a relationship between plasma insulin and coronary heart disease (CHD). Conventional nonspecific insulin assays are also measuring various fractions of proinsulin-like molecules due to cross-reactivity. The long-term relationship between proinsulin-like molecules and CHD is largely unknown. For this reason, the longitudinal relationships between intact proinsulin, split proinsulin, specific insulin, immunoreactive insulin, and CHD, were studied in a population-based cohort of 50-year-old men (n=874), with a follow-up of 27 years.

    METHODS AND RESULTS: Fasting proinsulin-like molecule and specific-insulin concentrations were measured in plasma (stored frozen since baseline 1970 to 1973) by specific 2-site immunometric assays. Immunoreactive insulin concentrations were determined at baseline. The associations between proinsulin-like molecules, specific insulin, immunoreactive insulin, and CHD mortality (International Classification of Diseases [9th revision] codes 410 to 414) were analyzed using Cox's proportional hazards regression and presented as hazard ratios (HRs) with their 95% confidence intervals (CIs) for a 1-SD increase in a predictor variable. In the univariate analysis, intact proinsulin (HR, 1.69; 95% CI, 1.41 to 2.01) was the strongest predictor of death from CHD. In the multivariate analysis, smoking (HR, 1.57; 95% CI, 1.03 to 2.38), intact proinsulin (HR, 1.47; 95% CI, 1.18 to 1.82), systolic blood pressure (HR, 1.38; 95% CI, 1.14 to 1.66), and LDL/HDL cholesterol ratio (HR, 1.31; 95% CI, 1.12 to 1.53) were independent predictors of CHD mortality (adjusted for body mass index, triglycerides, and fasting glucose), whereas specific insulin and immunoreactive insulin were not (HR, 1.12; 95% CI, 0.90 to 1.40). The increased risk was restricted to the upper third of the proinsulin distribution.

    CONCLUSION: Increased proinsulin concentrations predict death and morbidity caused by CHD over a period of 27 years, independent of other major cardiovascular risk factors.

  • 246796.
    Zethelius, Björn
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics. Med Prod Agcy, Uppsala, Sweden..
    Cederholm, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Comparison between indexes of insulin resistance for risk prediction of cardiovascular diseases or development of diabetes2015In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 110, no 2, p. 183-192Article in journal (Refereed)
    Abstract [en]

    Aim: The predictive effect of various insulin resistance indexes for risk of cardiovascular diseases (CVD) or type 2 diabetes (T2DM) is still unclear. Methods: One thousand and forty-nine 71-years-old male subjects from the Swedish ULSAM study, mean follow-up 9 years. All subjects performed the euglycemic insulin clamp for M/I [glucose disposal/mean insulin], and 75-g oral glucose tolerance test for Ceder-IR: 1/glucose uptake rate/[mean glucose x log mean insulin]; Matsuda-IR: 1/10,000/square root [glucose0 x insulin0 x glucose120 x insulin120]; Belfiore-IR: 1/([glucose0 + glucose120]/normal mean glucose x [insulin0 + insulin120]/normal mean insulin)+1); and HOMA-IR: [glucose0 x insulin0]/22.5. Results: Bland-Altman plots showed best agreement between M/I versus Belfiore-IR and Ceder-IR with mean difference near zero, -0.21 to -0.46, while -0.68 to -0.77 for the other indexes. ISI-Ceder was the strongest predictor for incident nonfatal/fatal ischemic heart disease (CHD) or CVD at Cox regression in all subjects, and for incident T2DM at logistic regression in 1024 subjects with no baseline T2DM, with significantly higher hazard ratios or odds ratios than with all other indexes, also with best model fit, after adjusting for clinical characteristics and the traditional cardiovascular risk factors, including metabolic syndrome for CVD risk. Conclusion: Ceder-IR performed strongest as independent predictor for incidences of CHD/CVD and T2DM.

  • 246797.
    Zethelius, Björn
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Eliasson, Björn
    Eeg-Olofsson, Katarina
    Svensson, Ann-Marie
    Gudbjörnsdottir, Soffia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Cederholm, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    A new model for 5-year risk of cardiovascular disease in type 2 diabetes, from the Swedish National Diabetes Register (NDR)2011In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 93, no 2, p. 276-284Article in journal (Refereed)
    Abstract [en]

    AIM:

    We assessed the association between risk factors and cardiovascular disease (CVD) in an observational study of type 2 diabetes patients from the Swedish National Diabetes Register.

    METHODS:

    A derivation sample of 24,288 patients, aged 30-74 years, 15.3% with previous CVD, baseline 2002, 2488 CVD events when followed for 5 years until 2007. A separate validation data set of 4906 patients, baseline 2003, 522 CVD events when followed for 4 years.

    RESULTS:

    Adjusted hazard ratios at Cox regression for fatal/nonfatal CVD were: onset-age 1.59, diabetes duration 1.55, total-cholesterol-to-HDL-cholesterol ratio 1.20, HbA1c 1.12, systolic BP 1.09, BMI 1.07 (1 SD increase in natural log continuous variables); males 1.41, smoker 1.35, microalbuminuria 1.27, macroalbuminuria 1.53, atrial fibrillation 1.50, previous CVD 1.98 (all p<0.001 except BMI p=0.0018). All 12 variables were used to elaborate an equation for 5-year CVD risk in the derivation dataset: mean 5-year risk 11.9±8.4%. Calibration in the validation dataset was adequate: ratio predicted 4-year risk/observed rate 0.97. Discrimination was sufficient: C statistic 0.72, sensitivity 51% and specificity 78% for top quartile.

    CONCLUSION:

    This CVD risk model from a large observational study of patients in routine care showed adequate calibration and discrimination, and can be useful for clinical practice.

  • 246798.
    Zethelius, Björn
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Gudbjornsdottir, S.
    Eliasson, B.
    Eeg-Olofsson, K.
    Svensson, A. -M
    Cederholm, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Risk factors for atrial fibrillation in type 2 diabetes: Report from the Swedish National Diabetes Register: NDR2014In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 57, no S1, p. S137-S138Article in journal (Other academic)
  • 246799.
    Zethelius, Björn
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Gudbjornsdottir, S
    Eliasson, B
    Eeg-Olofsson, K
    Svensson, AM
    Cederholm, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Risk prediction of cardiovascular disease in type 2 diabetes: a new risk equation from the Swedish NDR2010In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 53, no Suppl 1, p. S68-Article in journal (Refereed)
  • 246800.
    Zethelius, Björn
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Gudbjornsdottir, Soffia
    Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Med, Gothenburg, Sweden..
    Eliasson, Bjorn
    Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Med, Gothenburg, Sweden..
    Eeg-Olofsson, Katarina
    Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Med, Gothenburg, Sweden..
    Svensson, Ann-Marie
    Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Med, Gothenburg, Sweden..
    Cederholm, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Electrical atrial vulnerability and renal complications in type 2 diabetes. Reply to Montaigne D, Coisne A, Sosner P et al [letter]2016In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 59, no 4, p. 863-864Article in journal (Other academic)
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