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  • 246851.
    Åhrman, Caroline
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature.
    Konsten att berätta: En studie av ungdomsromanen Cirkeln2012Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 246852.
    Åhrén, Eva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Death, Modernity, and the Body: Sweden 1870-19402009Book (Other academic)
  • 246853.
    Åhrén, Eva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Human Remains: Dissection and its Histories, by Helen MacDonald2008In: Journal of social history, ISSN 0022-4529, E-ISSN 1527-1897, Vol. Winter, p. 539-541Article, book review (Other (popular science, discussion, etc.))
  • 246854.
    Åhrén, Eva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Läkaren, döden och brottet: studier i den svenska rättsmedicinens etablering (av Tony Gustafsson)2008In: Lychnos, ISSN 0076-1648, p. 322-327Article, book review (Other (popular science, discussion, etc.))
  • 246855.
    Åhrén, Eva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Medicinhistoria idag : perspektiv på det samtida svenska forskningsfältet2007Collection (editor) (Other academic)
  • 246856.
    Åhrén, Eva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Museerna: Vetenskap i tre dimensioner2010In: Medicinen blir till vetenskap: Karolinska Institutet under två århundraden / [ed] Karin Johannisson, Ingemar Nilsson & Roger Qvarsell, Solna: Karolinska Institutet University Press , 2010, p. 126-169Chapter in book (Other academic)
  • 246857.
    Åhrén, Eva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Skin: Curated by Javier Moscoso. Wellcome Collection, 183 Euston Road, London, June 10--September 26, 20102010In: Bulletin of The History of Medicine, ISSN 0007-5140, E-ISSN 1086-3176, Vol. 84, no 4, p. 677-678Article, book review (Other academic)
  • 246858.
    Åhrén, Eva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Studies in the Nervous System, Axel Key and Gustaf Retzius2012In: Hidden Treasure: The National Library of Medicine / [ed] Michael Sappol, New York: Blast Books , 2012, p. 214-217Chapter in book (Other academic)
  • 246859.
    Åhrén, Eva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    The Anatomy Murders: Being the True and Spectacular History of Edinburgh's Notorious Burke and Hare and of the Man of Science Who Abetted Them in the Commission of Their Most Heinous Crimes2011In: Journal of the history of medicine and allied sciences, ISSN 0022-5045, E-ISSN 1468-4373, Vol. 66, no 2, p. 251-253Article, book review (Refereed)
  • 246860.
    Åhrén, Eva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    The Lady Anatomist: The Life and Work of Anna Morandi Manzolini. By Rebecca Messbarger2012In: Journal of the history of medicine and allied sciences, ISSN 0022-5045, E-ISSN 1468-4373, Vol. 67Article, book review (Other academic)
  • 246861.
    Åhrén, Eva
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Nilsson, Ulrika
    Avd. för genusvetenskap, Center for Gender Studies, Stockholms universitet.
    Blickar och begär: Några reflexioner kring Karin Johannissons bildvärld2010In: In på bara huden: Medicinhistoriska studier tillägnade Karin Johannisson / [ed] Torbjörn Gustafsson Chorell & Maja Bondestam, Nora: Nya Doxa , 2010, p. 243-279Chapter in book (Other academic)
  • 246862.
    Åhrén, Eva
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Sappol, Michael
    National LIbrary of Medicine, National Institutes of Health, USA.
    The Culture of the Copy: Clorion’s First: Science—Anatomy (1829-30)2012In: Hidden Treasure: The National Library of Medicine / [ed] Michael Sappol, New York: Blast Books , 2012, p. 42-43Chapter in book (Other academic)
  • 246863.
    Åhrén, Eva
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Sappol, Michael
    History of Medicine Division, National Library of Health and Medicine, National Institutes of Health, Bethesda, Maryland, USA.
    The Strange Space of the Body: Two Dialogues2009In: Strange Spaces: Explorations into Mediated Obscurity / [ed] André Jansson & Amanda Lagerkvist, Aldershot: Asgate , 2009, p. 74-100Chapter in book (Other academic)
  • 246864.
    Åhrén, Tom
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
    Contraceptive vaginal rings: clinical studies with special reference to gestagenic effects on serum lipoproteins 1982Doctoral thesis, comprehensive summary (Other academic)
  • 246865.
    Åhs, Annika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Health and Health Care Utilization among the Unemployed2006Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The number of persons who are not employed has increased in Sweden since the early 1990s. Unemployment has been found to influence health, especially when unemployment rates are low. The extent to which unemployment affects health when unemployment is high is less clear, and this needs to be further studied. To improve health in the population, the health care system should offer equal access to health care according to need. It is important to study whether the employment status hinders the fulfilment of this goal.

    This thesis is based on four papers: Paper I and II aimed at analysing self-rated health versus mortality risk in relation to employment status, during one period of low unemployment and one period of high unemployment. Paper III and IV assessed the use of medical health care services and unmet care needs among persons who were unemployed or otherwise not employed. The goal was to analyse what health problems lead people to either seek or abstain from seeking care, and what factors encumber or facilitate this process.

    The overall results indicate that being unemployed or outside the labour force was associated with an excess risk of poor self-rated health, symptoms of depression, mental and physical exhaustion and mortality. The differences in self-rated health between the unemployed and employed were larger when unemployment levels were high, than when they were low. More groups of the unemployed were also afflicted with poor health when unemployment was high. Thus, poor health among the unemployed seems to be a public health problem during high levels of unemployment. Lack of employment was related to abstaining from seeking care, despite perceiving a need for care, and this was related to psychological symptoms. To deal with the needs of the unemployed and others who are outside the labour force it would be useful to develop and implement interventions within the health care system. These should focus on psychological and psychosocial problems. Future research should analyse how to facilitate health-promoting interventions among persons who are not anchored in the labour market.

    List of papers
    1. Self-rated health in relation to employment status during periods of high and low levels of unemployment
    Open this publication in new window or tab >>Self-rated health in relation to employment status during periods of high and low levels of unemployment
    2006 (English)In: European Journal of Public Health, ISSN 1101-1262, E-ISSN 1464-360X, Vol. 16, no 3, p. 294-304Article in journal (Refereed) Published
    Abstract [en]

    BACKGROUND: There is a need for more research on the health impact of changes in the national unemployment rate. Therefore, the present study was carried out to compare levels of self-rated health during periods of high and low levels of unemployment.

    METHODS: Data included cross-sectional interviews from the Swedish Survey of Living Conditions, which were based on random samples of inhabitants between 16 and 64 years of age living in Sweden. Data were collected for the period 1983-89, when unemployment levels were low (n = 35 562; 2.5%) and for the period 1992-97 when unemployment was high (n = 24 019; 7.1%).

    RESULTS: After adjusting for sociodemographic variables as well as long-term disease or handicap, the differences in self-rated health between the unemployed and employed were larger when unemployment levels were high in the 1990s, than when they were low in the 1980s. More groups of the unemployed were afflicted with poor health when unemployment was high, compared with when it was low. In 1992-97, being married, living in larger cities, or not having a long-term disease or handicap no longer buffered the negative effects on health among the unemployed.

    CONCLUSIONS: Poorer self-rated health among the unemployed seems to be an increasing public health problem during high levels of unemployment.

    Keywords
    level of unemployment, self-rated health, unemployment
    National Category
    Public Health, Global Health, Social Medicine and Epidemiology
    Identifiers
    urn:nbn:se:uu:diva-94980 (URN)10.1093/eurpub/cki165 (DOI)000238762100017 ()16260444 (PubMedID)
    Available from: 2006-10-13 Created: 2006-10-13 Last updated: 2017-12-14Bibliographically approved
    2.
    The record could not be found. The reason may be that the record is no longer available or you may have typed in a wrong id in the address field.
    3. Health care utilization among persons who are unemployed or outside the labour force
    Open this publication in new window or tab >>Health care utilization among persons who are unemployed or outside the labour force
    2006 (English)In: Health Policy, ISSN 0168-8510, E-ISSN 1872-6054, Vol. 78, no 2-3, p. 178-193Article in journal (Refereed) Published
    Abstract [en]

    Background: In Sweden, equity in health is a central aim of public health policy. To this end, the health care system is obligated to offer equal access to health care according to need. However, unemployment may hinder the fulfillment of this goal. The aim of the present study was to assess self-reported health care needs and service utilization with respect to employment status.

    Methods: A questionnaire was sent to 4000 randomly chosen individuals 20-64 years of age living in different counties in Sweden (response rate 66.2%). Logistic regression analyses were carried out to estimate the influence of employment status, socio-demographic variables and health indicators on the need for and use of health care services.

    Results: In total, 42.2% (n=35) among the unemployed, 37.4% (n=55) among persons who were on long-term sick leave (LTSD), and 22.3% (n=467) of the employed persons, abstained from consulting a physician despite reporting a perceived need to do so. The results persisted after adjusting for socio-demographic variables, social support and personal finances (unemployed: OR= 1.91; LTSD: OR= 1.62). The risk of foregoing care remained higher among the unemployed, but not the LTSD-group, after adjusting for long-standing illness (OR= 1.94). The unemployed were more likely than the employed to perceive a need to seek care for psychological problems. The risk of abstaining from consulting a physician was related to symptoms of depression.

    Conclusions: Lack of employment may be related to unmet care needs, especially among unemployed who are experiencing psychological symptoms. To deal with the needs of the unemployed it may be useful to develop interventions within the health care system that focus more on psychological problems.

    Keywords
    Unemployment, Health care utilization, Perceived unmet care needs
    National Category
    Public Health, Global Health, Social Medicine and Epidemiology
    Identifiers
    urn:nbn:se:uu:diva-94982 (URN)10.1016/j.healthpol.2005.10.010 (DOI)000240837500007 ()16343685 (PubMedID)
    Available from: 2006-10-13 Created: 2006-10-13 Last updated: 2017-12-14Bibliographically approved
    4. Predictors of health and health care utilization in relation to employment status.
    Open this publication in new window or tab >>Predictors of health and health care utilization in relation to employment status.
    2006 (English)In: European Journal of Public Health, ISSN 1101-1262, E-ISSN 1464-360X, Vol. 16, no Suppl. 1, p. 180-Article in journal (Refereed) Published
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-104969 (URN)
    Available from: 2009-05-31 Created: 2009-05-31 Last updated: 2017-12-13
  • 246866.
    Åhs, Annika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Projekt Inspira Integrerad behandling för personer med psykisk ohälsa inom etableringen i Uppsala län: Utvärderingsrapport: December 20162016Report (Other academic)
  • 246867.
    Åhs, Annika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Burell, Gunilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Care or not care - that is the question: predictors of healthcare utilisation in relation to employment status2012In: International Journal of Behavioral Medicine, ISSN 1070-5503, E-ISSN 1532-7558, Vol. 19, no 1, p. 29-38Article in journal (Refereed)
    Abstract [en]

    BACKGROUND

    International research shows that there is a higher use of care among the unemployed than among the employed, although the findings on the association between unemployment and healthcare use are not conclusive.

    PURPOSE

    To examine the association between healthcare use and employment status and the factors influencing this relationship.

    METHOD

    During 2002, a questionnaire was sent to 1,000 persons who had recently registered as unemployed (participation rate: n = 570) and to a sample of 1,000 persons representing the Swedish population (participation rate: n = 641). The study design was cross-sectional. Persons still unemployed or otherwise not employed (n = 416) were compared with the employed (n = 414) using logistic regression analyses.

    RESULTS

    About half of those in the unemployed group had contacted a physician. The unemployed were also more likely to have needed but not sought care. Being in the unemployed group was a statistically significant risk factor for reporting unmet care needs, after adjusting for sociodemographic factors (OR = 1.53). The risk of abstaining from seeking care did not persist when considering economy and social network. Among those with unmet care needs, there was still a higher risk in the unemployed group of reporting: a small social network (OR = 2.73), economic hardship (OR = 2.87) and symptoms of depression (OR = 2.04).

    CONCLUSIONS

    Unemployment is a risk factor for both contacting a physician and for unmet care needs. A low social network and economic hardship are more present among persons who abstain from seeking healthcare and seem to be more common among the unemployed. The healthcare system should also be aware of the fact that some unemployed people with symptoms of depression abstain from seeking care.

  • 246868.
    Åhs, Annika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Burell, Gunilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Predictors of health and health care utilization in relation to employment status.2006In: European Journal of Public Health, ISSN 1101-1262, E-ISSN 1464-360X, Vol. 16, no Suppl. 1, p. 180-Article in journal (Refereed)
  • 246869.
    Åhs, Annika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Nummi, T.
    Univ Tampere, Fac Nat Sci, Tampere, Finland..
    Hammarström, Anne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Public Health.
    Gender inequalities in common mental disorders over the life course2017In: European Journal of Public Health, ISSN 1101-1262, E-ISSN 1464-360X, Vol. 27Article in journal (Other academic)
  • 246870.
    Åhs, Annika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Health care utilization among persons who are unemployed or outside the labour force2006In: Health Policy, ISSN 0168-8510, E-ISSN 1872-6054, Vol. 78, no 2-3, p. 178-193Article in journal (Refereed)
    Abstract [en]

    Background: In Sweden, equity in health is a central aim of public health policy. To this end, the health care system is obligated to offer equal access to health care according to need. However, unemployment may hinder the fulfillment of this goal. The aim of the present study was to assess self-reported health care needs and service utilization with respect to employment status.

    Methods: A questionnaire was sent to 4000 randomly chosen individuals 20-64 years of age living in different counties in Sweden (response rate 66.2%). Logistic regression analyses were carried out to estimate the influence of employment status, socio-demographic variables and health indicators on the need for and use of health care services.

    Results: In total, 42.2% (n=35) among the unemployed, 37.4% (n=55) among persons who were on long-term sick leave (LTSD), and 22.3% (n=467) of the employed persons, abstained from consulting a physician despite reporting a perceived need to do so. The results persisted after adjusting for socio-demographic variables, social support and personal finances (unemployed: OR= 1.91; LTSD: OR= 1.62). The risk of foregoing care remained higher among the unemployed, but not the LTSD-group, after adjusting for long-standing illness (OR= 1.94). The unemployed were more likely than the employed to perceive a need to seek care for psychological problems. The risk of abstaining from consulting a physician was related to symptoms of depression.

    Conclusions: Lack of employment may be related to unmet care needs, especially among unemployed who are experiencing psychological symptoms. To deal with the needs of the unemployed it may be useful to develop interventions within the health care system that focus more on psychological problems.

  • 246871.
    Åhs, Annika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Mortality in relation to employment status during different levels of unemployment2006In: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 34, no 2, p. 159-67Article in journal (Refereed)
  • 246872.
    Åhs, Annika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Self-rated health in relation to employment status during periods of high and low levels of unemployment2006In: European Journal of Public Health, ISSN 1101-1262, E-ISSN 1464-360X, Vol. 16, no 3, p. 294-304Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: There is a need for more research on the health impact of changes in the national unemployment rate. Therefore, the present study was carried out to compare levels of self-rated health during periods of high and low levels of unemployment.

    METHODS: Data included cross-sectional interviews from the Swedish Survey of Living Conditions, which were based on random samples of inhabitants between 16 and 64 years of age living in Sweden. Data were collected for the period 1983-89, when unemployment levels were low (n = 35 562; 2.5%) and for the period 1992-97 when unemployment was high (n = 24 019; 7.1%).

    RESULTS: After adjusting for sociodemographic variables as well as long-term disease or handicap, the differences in self-rated health between the unemployed and employed were larger when unemployment levels were high in the 1990s, than when they were low in the 1980s. More groups of the unemployed were afflicted with poor health when unemployment was high, compared with when it was low. In 1992-97, being married, living in larger cities, or not having a long-term disease or handicap no longer buffered the negative effects on health among the unemployed.

    CONCLUSIONS: Poorer self-rated health among the unemployed seems to be an increasing public health problem during high levels of unemployment.

  • 246873.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    A META-ANALYSIS OF STUDIES OF THE NEURAL CORRELATES OF HEART RATE VARIABILITY: IMPORTANCE OF THE AMYGDALA AND THE MEDIAL PREFRONTAL CORTEX2010In: Psychophysiology 47, S7-S7, 2010Conference paper (Other academic)
  • 246874.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Age and Sex Differences in NK1 Receptor Availability Assessed with 11C GR2051712010In: Biol. Psychiatry 67, 206S-206S, 2010Conference paper (Refereed)
  • 246875.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Amygdala response to SSRIs in social anxiety disorder2012In: Int. J. Neuropsychopharmacol. 15, 230-230, 2012Conference paper (Refereed)
  • 246876.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Amygdalar activity during emotional perception and experience in subjects with social phobia2005In: Biol. Psychiatry 57, 170S-170S, 2005Conference paper (Other academic)
  • 246877.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Delay and trace conditioning following unilateral temporal lobectomy2006In: Biol. Psychiatry 59, 90S-90S, 2006Conference paper (Other academic)
  • 246878.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Differences in activation between current and former cocaine users using a monetary incentive delay task2008In: Biol. Psychiatry 63, 169S-169S, 2008Conference paper (Other academic)
  • 246879.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Enhanced amygdalar activation during perception of negative affect in patients with social phobia carrying the short allele of the human serotonin transporter gene2006In: Biol. Psychiatry 59, 244S-244S, 2006Conference paper (Other academic)
  • 246880.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    High-frequency heart rate variability during stress correlates with anterior cingulate regional cerebral blood flow in patients with social phobia2008In: International Journal of Psychophysiology 69, 194-194, 2008Conference paper (Other academic)
  • 246881.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Neural Correlates of Anxiety States in Patients with Social Anxiety Disorder2011In: Biol. Psychiatry 69, 70S-70S, 2011Conference paper (Refereed)
  • 246882.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Neurofunctional placebo response in social anxiety disorder during public speech2005In: Biol. Psychiatry 57, 170S-171S, 2005Conference paper (Other academic)
  • 246883.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Rapid Plasticity in the Olfactory System Modulates Detection Threshold in an Odorant-Specific Manner2009In: Chemical Senses 34, A110-A110, 2009Conference paper (Other academic)
  • 246884.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Serotonin transporter gene polymorphism and amygdala habituation during a stressful public speaking task: A PET study of social phobia2008In: Biol. Psychiatry 63, 171S-172S, 2008Conference paper (Other academic)
  • 246885.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Startle potentiation is modulated by the medial temporal lobes in aversive anticipation but not in aversive sensitization2007In: Biol. Psychiatry 61, 28S-28S, 2007Conference paper (Refereed)
  • 246886.
    Åhs, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    The Amygdala, Arousal and Memory: From Lesions to Neuroimaging2009Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Emotional events are better remembered than neutral events. But what are the mechanisms behind this memory enhancing effect? It seems that they depend on the arousal level at the moment we experience the event to be remembered.

    The first study of the present thesis mapped the brain areas that changed their activity in a highly arousing situation in subjects with snake or spider phobia. Looking at pictures of their feared object engaged the amygdala, situated in the medial temporal lobe. This area has previously been demonstrated to be necessary for fear reactions. Here, the novel question was what other brain areas the amygdala engages when the brain is in a state of high arousal. Results suggest that the amygdala recruits other limbic and cortical areas known to be involved in motor behavior and object recognition. In contrast, when subjects watched fear-relevant but non-phobic pictures, amygdala activity was negatively correlated to the anterior cingulate cortex suggesting cortical inhibition.

    The final two studies aimed at explaining the physiological brain mechanisms behind arousal enhancement of memory. In the first one, epileptic patients with medial temporal lobe resections including the amygdala were compared to healthy controls on a recognition memory task where the pictures to be remembered varied in arousal intensities. Results suggested that the anterior medial temporal lobe including the amygdala is necessary for arousal enhancement of memory because the enhancement effect was abolished in resectioned patients.

    The last study related inter-individual differences in bodily arousal to amygdala-parahippocampal interaction. Results suggest that the beneficial effects of emotion on memory depend on arousal regulating mechanisms of the amygdala that in turn affects parahippocampal activity.

    Collectively, results suggest that the amygdala is regulating changes in arousal states of the brain and body during distressful situations. Further, arousal in turn determines memory strength through gating amygdala influences on the parahippocampal cortex. Thus, the amygdala is a node both in a fear and a memory network and arousal influences the amygdala to prepare for action and to enhance memory. This seems evolutionary sound.

     

    List of papers
    1. Disentangling the web of fear: amygdala reactivity and functional connectivity in spider and snake phobia
    Open this publication in new window or tab >>Disentangling the web of fear: amygdala reactivity and functional connectivity in spider and snake phobia
    Show others...
    2009 (English)In: Psychiatry Research: Neuroimaging, ISSN 0925-4927, E-ISSN 1872-7506, Vol. 172, no 2, p. 103-108Article in journal (Refereed) Published
    Abstract [en]

    The objective was to study effects of fear on brain activity, functional connectivity and brain-behavior relationships during symptom provocation in subjects with specific phobia. Positron emission tomography (PET) and (15)O water was used to measure regional cerebral blood flow (rCBF) in 16 women phobic of either snakes or spiders but not both. Subjects watched pictures of snakes and spiders serving either as phobic or fear-relevant, but non-phobic, control stimuli depending on phobia type. Presentation of phobic as compared with non-phobic cues was associated with increased activation of the right amygdala and cerebellum as well as the left visual cortex and circumscribed frontal areas. Activity decreased in the prefrontal, orbitofrontal and ventromedial cortices as well as in the primary somatosensory cortex and auditory cortices. Furthermore, amygdala activation correlated positively with the subjective experience of distress. Connectivity analyses of activity in the phobic state revealed increased functional couplings between voxels in the right amygdala and the periamygdaloid area, fusiform gyrus and motor cortex. During non-phobic stimulation, prefrontal activity correlated negatively with amygdala rCBF, suggesting a phobia-related functional decoupling. These results suggest that visually elicited phobic reactions activate object recognition areas and deactivate prefrontal areas involved in cognitive control over emotion-triggering areas like the amygdala, resulting in motor readiness to support fight or flight.

    Keywords
    Specific phobia, anxiety, fear-circuit, PET, subjective experience
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-98987 (URN)10.1016/j.pscychresns.2008.11.004 (DOI)000265779800003 ()19321315 (PubMedID)
    Available from: 2009-03-05 Created: 2009-03-05 Last updated: 2017-12-13Bibliographically approved
    2. Arousal enhanced memory retention is eliminated following temporal lobe resection
    Open this publication in new window or tab >>Arousal enhanced memory retention is eliminated following temporal lobe resection
    2010 (English)In: Brain and Cognition, ISSN 0278-2626, E-ISSN 1090-2147, Vol. 73, no 3, p. 176-179Article in journal (Refereed) Published
    Abstract [en]

    The amygdala, situated in the anterior medial temporal lobe (MTL), is involved in the emotional enhancement of memory. The present study evaluated whether anterior MTL-resections attenuated arousal induced memory enhancement for pictures. Also, the effect of MTL-resections on response latencies at retrieval was assessed. Thirty-one patients with unilateral MTL-resections (17 left, 14 right) together with 16 controls participated in a forced choice memory task with pictorial stimuli varying in arousal. Response latencies increased with stimulus arousal in controls but not in patients. This was paralleled by attenuated recognition memory for moderately and highly arousing pictures in MTL-resectioned patients as compared to healthy controls. However, patients and controls did not differ in memory performance for non-arousing pictures. These results suggest that the MTL is necessary for arousal induced memory enhancement.

    Keywords
    Amygdala, Emotion, IAPS pictures, Medial temporal lobe, Response latency
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-98986 (URN)10.1016/j.bandc.2010.04.009 (DOI)000280020300004 ()
    Available from: 2009-03-05 Created: 2009-03-05 Last updated: 2017-12-13Bibliographically approved
    3. Arousal gates amygdala interaction with the parahippocampal cortex during encoding of phobic pictures
    Open this publication in new window or tab >>Arousal gates amygdala interaction with the parahippocampal cortex during encoding of phobic pictures
    Show others...
    (English)Article in journal (Other academic) Submitted
    Identifiers
    urn:nbn:se:uu:diva-98991 (URN)
    Available from: 2009-03-05 Created: 2009-03-05 Last updated: 2011-01-11Bibliographically approved
  • 246887.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Bjurström, A
    Fredriksson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Furmark, Tomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Pissiota, A
    Linnman, Clas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Michelgård, A
    Appel, L
    Bani, M
    Merlo Pich, E
    Zancan, S
    Långström, B
    Gustavsson, M
    Connectivity analyses of regional cerebral blood flow during public speaking in individuals with social anxiety disorder2005Conference paper (Other (popular science, discussion, etc.))
  • 246888.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Björkstrand, Johannes
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Rewarded approach of threatening spiders engages areas of the mesolimbic dopamine system2016Conference paper (Refereed)
  • 246889.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Dunsmoor, Joseph E.
    Zielinski, David
    LaBar, Kevin S.
    Spatial proximity amplifies valence in emotional memory and defensive approach-avoidance2015In: Neuropsychologia, ISSN 0028-3932, E-ISSN 1873-3514, Vol. 70, p. 476-485Article in journal (Refereed)
    Abstract [en]

    In urban areas, people often have to stand or move in close proximity to others. The egocentric distance to stimuli is a powerful determinant of defensive behavior in animals. Yet, little is known about how spatial proximity to others alters defensive responses in humans. We hypothesized that the valence of social cues scales with egocentric distance, such that proximal social stimuli have more positive or negative valence than distal stimuli. This would predict enhanced defensive responses to proximal threat and reduced defensive responses to proximal reward. We tested this hypothesis across four experiments using 3-D virtual reality simulations. Results from Experiment 1 confirmed that proximal social stimuli facilitate defensive responses, as indexed by fear-potentiated startle, relative to distal stimuli. Experiment 2 revealed that interpersonal defensive boundaries flexibly increase with aversive learning. Experiment 3 examined whether spatial proximity enhances memory for aversive experiences. Fear memories for social threats encroaching on the body were more persistent than those acquired at greater interpersonal distances, as indexed by startle. Lastly, Experiment 4 examined how egocentric distance influenced startle responses to social threats during defensive approach and avoidance. Whereas fear-potentiated startle increased with proximity when participants actively avoided receiving shocks, startle decreased with proximity when participants tolerated shocks to receive monetary rewards, implicating opposing gradients of distance on threat versus reward. Thus, proximity in egocentric space amplifies the valence of social stimuli that, in turn, facilitates emotional memory and approach-avoidance responses. These findings have implications for understanding the consequences of increased urbanization on affective interpersonal behavior.

  • 246890.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Engman, Jonas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Persson, Jonas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Larsson, Elna-Marie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
    Wikström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
    Kumlien, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Medial temporal lobe resection attenuates superior temporal sulcus response to faces2014In: Neuropsychologia, ISSN 0028-3932, E-ISSN 1873-3514, Vol. 61, p. 291-298Article in journal (Refereed)
    Abstract [en]

    Face perception depends on activation of a core face processing network including the fusiform face area, the occipital face area and the superior temporal sulcus (STS). The medial temporal lobe (MTL) is also involved in decoding facial expression and damage to the anterior MTL, including the amygdala, generally interferes with emotion recognition. The impairment in emotion recognition following anterior MTL injury can be a direct result from injured MTL circuitry, as well as an indirect result from decreased MTL modulation of areas in the core face network. To test whether the MTL modulates activity in the core face network, we used functional magnetic resonance imaging to investigate activation in the core face processing network in patients with right or left anterior temporal lobe resections (ATR) due to intractable epilepsy. We found reductions of face-related activation in the right STS after both right and left ATR together with impaired recognition of facial expressions. Reduced activity in the fusiform and the occipital face areas was also observed in patients after right ATR suggesting widespread effects on activity in the core face network in this group. The reduction in face-related STS activity after both right and left ATR suggests that MTL modulation of the STS may facilitate recognition of facial expression.

  • 246891.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Frans, Örjan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Tibblin, Bodil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Kumlien, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    The effects of medial temporal lobe resections on verbal threat and fear conditioning2010In: Biological Psychology, ISSN 0301-0511, E-ISSN 1873-6246, Vol. 83, no 1, p. 41-46Article in journal (Refereed)
    Abstract [en]

    A left hemisphere advantage in the processing of verbal threat has previously been reported, whereas both hemispheres seem equally important in fear conditioning. Here, we compared the effects of unilateral medial temporal lobe (MTL) resections on verbal threat as well as delay and trace fear conditioning. During verbal threat, right and left MTL-resections attenuated fear potentiated startle in comparison with controls. In contrast to previous studies, MTL-resections did not attenuate delay conditioning of skin conductance responses. Left and right resectioned patients did not differ in psychophysiological responses to verbal threat or delay fear conditioning. Trace conditioning was not observed in any group. Results suggest a bilateral MTL hemispheric involvement in the processing of verbal threat, whereas one intact hemisphere seems sufficient for delay conditioning.

  • 246892.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Frick, Andreas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Furmark, Tomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Human serotonin transporter availability predicts fear conditioning2015In: International Journal of Psychophysiology, ISSN 0167-8760, E-ISSN 1872-7697, Vol. 98, no 3, p. 515-519Article in journal (Refereed)
  • 246893.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Furmark, Tomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Michelgård, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Långström, B.
    Appel, L.
    Wolff, O. T.
    Kirschbaum, C.
    Fredriksson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Hypothalamic blood flow correlates positively with stress-induced cortisol levels in subjects with social anxiety disorder2006In: Psychosomatic Medicine, ISSN 0033-3174, E-ISSN 1534-7796, Vol. 68, no 6, p. 859-862Article in journal (Refereed)
    Abstract [en]

    Objective: The adrenal excretion of cortisol in animals is dependent on the production of corticotropin-releasing factor in the paraventricular nucleus of the hypothalamus. The a priori hypothesis of this study was that hypothalamic regional cerebral blood flow (rCBF) would correlate positively with salivary cortisol levels in patients with social anxiety disorder (SAD) during anxiety provocation. Another objective was to evaluate whether salivary cortisol levels correlated with rCBF in other brain areas. Method: Regional CBF was measured with oxygen-15-labeled water and positron emission tomography during a public speaking task before and after placebo treatment in 12 subjects with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-defined SAD. Cortisol concentrations in saliva were measured 15 minutes after the task. The a priori hypothesis of a salivary cortisol-dependent activation of the hypothalamus was studied with region-of-interest analysis. In addition, the covariation between rCBF and salivary cortisol was studied in the whole brain using the general linear model. Results: The region-of-interest analysis revealed a positive correlation between salivary cortisol and hypothalamic rCBF. In the whole brain analysis, a positive covariation between rCBF and salivary cortisol levels was found in a midbrain cluster encompassing the hypothalamus with its statistical maximum in the mamillary bodies. Negative covariations were observed in the medial prefrontal cortex as well as in the motor and premotor cortices. Conclusion: Like in animals, stress-induced cortisol excretion in humans may be inhibited by activity in the medial prefrontal cortex and enhanced by activity in the hypothalamus.

  • 246894.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Gingnell, Malin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Furmark, Tomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Within-session effect of repeated stress exposure on extinction circuitry function in social anxiety disorder2017In: Psychiatry Research: Neuroimaging, ISSN 0925-4927, E-ISSN 1872-7506, Vol. 261, p. 85-90Article in journal (Refereed)
    Abstract [en]

    Anxiety reduction following repeated exposure to stressful experiences is generally held to depend on neural processes involved in extinction of conditioned fear. We predicted that repeated exposure to stressful experiences would change activity throughout the circuitry serving extinction, including ventromedial prefrontal cortex (vmPFC), the hippocampus and the amygdala. To test this prediction, 36 participants diagnosed with SAD performed two successive speeches in front of an observing audience while regional cerebral blood flow (rCBF) was recorded using positron emission tomography. To control for non-anxiolytic effects of repeated exposure, rCBF was also measured during repeated presentations of neutral and angry facial expressions. Results showed that anxiety ratings and heart rate decreased from the first to the second speech, indicating an anxiolytic effect of repeated exposure. Exposure attenuated rCBF in the amygdala whereas no change in rCBF was observed in the vmPFC or hippocampus. The rCBF-reductions in the amygdala were greater following repetition of the speech task than repetition of face exposure indicating that they were specific to anxiety attenuation and not due to a reduced novelty. Our findings suggest that amygdala-related attenuation processes are key to understanding the working mechanisms of exposure therapy.

  • 246895.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Duke Univ, Ctr Cognit Neurosci, Durham, NC 27708 USA.;Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Kragel, Philip A.
    Duke Univ, Ctr Cognit Neurosci, Durham, NC 27708 USA..
    Zielinski, David J.
    Duke Univ, Pratt Sch Engn, Durham, NC 27708 USA..
    Brady, Rachael
    Duke Univ, Pratt Sch Engn, Durham, NC 27708 USA..
    LaBar, Kevin S.
    Duke Univ, Ctr Cognit Neurosci, Durham, NC 27708 USA..
    Medial prefrontal pathways for the contextual regulation of extinguished fear in humans2015In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 122, p. 262-271Article in journal (Refereed)
    Abstract [en]

    The maintenance of anxiety disorders is thought to depend, in part, on deficits in extinction memory, possibly due to reduced contextual control of extinction that leads to fear renewal. Animal studies suggest that the neural circuitry responsible fear renewal includes the hippocampus, amygdala, and dorsomedial (dmPFC) and ventromedial (vmPFC) prefrontal cortex. However, the neural mechanisms of context-dependent fear renewal in humans remain poorly understood. We used functional magnetic resonance imaging (fMRI), combined with psychophysiology and immersive virtual reality, to elucidate how the hippocampus, amygdala, and dmPFC and vmPFC interact to drive the context-dependent renewal of extinguished fear. Healthy human participants encountered dynamic fear-relevant conditioned stimuli (CSs) while navigating through 3-D virtual reality environments in the MRI scanner. Conditioning and extinction were performed in two different virtual contexts. Twenty-four hours later, participants were exposed to the CSs without reinforcement while navigating through both contexts in the MRI scanner. Participants showed enhanced skin conductance responses (SCRs) to the previously-reinforced CS + in the acquisition context on Day 2, consistent with fear renewal, and sustained responses in the dmPFC. In contrast, participants showed low SCRs to the CSs in the extinction context on Day 2, consistent with extinction recall, and enhanced vmPFC activation to the non-reinforced CS -. Structural equation modeling revealed that the dmPFC fully mediated the effect of the hippocampus on right amygdala activity during fear renewal, whereas the vmPFC partially mediated the effect of the hippocampus on right amygdala activity during extinction recall. These results indicate dissociable contextual influences of the hippocampus on prefrontal pathways, which, in turn, determine the level of reactivation of fear associations.

  • 246896.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Kumlien, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Arousal enhanced memory retention is eliminated following temporal lobe resection2010In: Brain and Cognition, ISSN 0278-2626, E-ISSN 1090-2147, Vol. 73, no 3, p. 176-179Article in journal (Refereed)
    Abstract [en]

    The amygdala, situated in the anterior medial temporal lobe (MTL), is involved in the emotional enhancement of memory. The present study evaluated whether anterior MTL-resections attenuated arousal induced memory enhancement for pictures. Also, the effect of MTL-resections on response latencies at retrieval was assessed. Thirty-one patients with unilateral MTL-resections (17 left, 14 right) together with 16 controls participated in a forced choice memory task with pictorial stimuli varying in arousal. Response latencies increased with stimulus arousal in controls but not in patients. This was paralleled by attenuated recognition memory for moderately and highly arousing pictures in MTL-resectioned patients as compared to healthy controls. However, patients and controls did not differ in memory performance for non-arousing pictures. These results suggest that the MTL is necessary for arousal induced memory enhancement.

  • 246897.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Michelgård Palmquist, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Pissiota, Anna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Appel, Lieuwe
    Frans, Örjan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Liberzon, Israel
    Furmark, Tomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Arousal modulation of memory and amygdala-parahippocampal connectivity: A PET-psychophysiology study in specific phobia2011In: Psychophysiology, ISSN 0048-5772, E-ISSN 1469-8986, Vol. 48, no 11, p. 1463-1469Article in journal (Refereed)
    Abstract [en]

    Phobic fear is accompanied by intense bodily responses modulated by the amygdala. An amygdala moderated psychophysiological measure related to arousal is electrodermal activity. We evaluated the contributions of electrodermal activity to amygdala-parahippocampal regional cerebral blood flow (rCBF) during phobic memory encoding in subjects with spider or snake phobia. Recognition memory was increased for phobia-related slides and covaried with rCBF in the amygdala and the parahippocampal gyrus. The covariation between parahippocampal rCBF and recognition was related to electrodermal activity suggesting that parahippocampal memory processes were associated with sympathetic activity. Electrodermal activity further mediated the amygdala effect on parahippocampal activity. Memory encoding during phobic fear therefore seems contingent on amygdala's influence on arousal and parahippocampal activity.

  • 246898.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Michelgård Palmquist, Åsa
    Pissiota, Anna
    Frans, Örjan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Furmark, Tomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Cortico-Striatal Substance P Release Correlates with Phobia Related Trait Anxiety2010Conference paper (Refereed)
  • 246899.
    Åhs, Fredrik
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Psychology.
    Michelgård, Åsa
    Fredrikson, Mats
    Wolf, O.T.
    Kirschbaum, C.
    Appel, Lieuwe
    Furmark, Tomas
    Central neural correlates of salivary cortisol during stress in subjects with social phobia2004In: Biological Psychiatry, 55, Suppl. 8, 2004, p. 211S-Conference paper (Refereed)
  • 246900.
    Åhs, Fredrik
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Psychology.
    Michelgård, Åsa
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Psychology.
    Fredrikson, Mats
    Wolf, O.T.
    Kirschbaum, C.
    Appel, Lieuwe
    Furmark, Tomas
    Central neural correlates of salivary cortisol in social phobics performing a speech2003In: Psychophysiology, 40, Suppl. 1, 2003, p. S21-Conference paper (Refereed)
4935493649374938493949404941 246851 - 246900 of 249970
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