uu.seUppsala University Publications
Change search
Refine search result
4936493749384939494049414942 246901 - 246950 of 249970
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 246901.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Michelgård, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Pissiota, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Appel, Lieuwe
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    Frans, Örjan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Furmark, Tomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Arousal gates amygdala interaction with the parahippocampal cortex during encoding of phobic picturesArticle in journal (Other academic)
  • 246902.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Michelgård, Åsa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Pissiota, Anna
    Uppsala University.
    Furmark, Tomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Appel, Lieuwe
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Bodily arousal gates amygdala-hippocampal interaction in phobic memory encoding2009In: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 65, no 8, p. 126S-126SArticle in journal (Other academic)
  • 246903.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Miller, Stacie S
    Gordon, Amy R
    Lundström, Johan N
    Aversive learning increases sensory detection sensitivity.2013In: Biological Psychology, ISSN 0301-0511, E-ISSN 1873-6246, Vol. 92, no 2, p. 135-41Article in journal (Refereed)
    Abstract [en]

    Increased sensitivity to specific cues in the environment is common in anxiety disorders. This increase in sensory processing can emerge through attention processes that enhance discrimination of a cue from other cues as well as through augmented senses that reduce the absolute intensity of sensory stimulation needed for detection. Whereas it has been established that aversive conditioning can enhance odor quality discrimination, it is not known whether it also changes the absolute threshold at which an odor can be detected. In two separate experiments, we paired one odor of an indistinguishable odor pair with an aversive outcome using a classical conditioning paradigm. Ability to discriminate and to detect the paired odor was assessed before and after conditioning. The results demonstrate that aversive conditioning increases absolute sensory sensitivity to a predictive odor cue in an odor-specific manner, rendering the conditioned odor detectable at a significantly lower (20%) absolute concentration. As animal research has found long-lasting change in behavior and neural signaling resulting from conditioning, absolute threshold was also tested eight weeks later. Detection threshold had returned to baseline level at the eight week follow-up session suggesting that the change in detection threshold was mediated by a transient reorganization. Taken together, we can for the first time demonstrate that increasing the biological salience of a stimulus augments the individual's absolute sensitivity in a stimulus-specific manner outside conscious awareness. These findings provide a unique framework for understanding sensory mechanisms in anxiety disorders as well as further our understanding of mechanisms underlying classical conditioning.

  • 246904.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Pissiota, Anna
    Uppsala University.
    Michelgård, Åsa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Appel, Lieuwe
    Furmark, Tomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Functional connectivity of the amygdala in specific phobia2008In: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 63, no 7, p. 169S-169SArticle in journal (Other academic)
  • 246905.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Pissiota, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, Ulleråker, University Hospital.
    Michelgård, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Frans, Örjan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Furmark, Tomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Appel, Lieuwe
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
    Fredrikson, Mats
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Disentangling the web of fear: amygdala reactivity and functional connectivity in spider and snake phobia2009In: Psychiatry Research: Neuroimaging, ISSN 0925-4927, E-ISSN 1872-7506, Vol. 172, no 2, p. 103-108Article in journal (Refereed)
    Abstract [en]

    The objective was to study effects of fear on brain activity, functional connectivity and brain-behavior relationships during symptom provocation in subjects with specific phobia. Positron emission tomography (PET) and (15)O water was used to measure regional cerebral blood flow (rCBF) in 16 women phobic of either snakes or spiders but not both. Subjects watched pictures of snakes and spiders serving either as phobic or fear-relevant, but non-phobic, control stimuli depending on phobia type. Presentation of phobic as compared with non-phobic cues was associated with increased activation of the right amygdala and cerebellum as well as the left visual cortex and circumscribed frontal areas. Activity decreased in the prefrontal, orbitofrontal and ventromedial cortices as well as in the primary somatosensory cortex and auditory cortices. Furthermore, amygdala activation correlated positively with the subjective experience of distress. Connectivity analyses of activity in the phobic state revealed increased functional couplings between voxels in the right amygdala and the periamygdaloid area, fusiform gyrus and motor cortex. During non-phobic stimulation, prefrontal activity correlated negatively with amygdala rCBF, suggesting a phobia-related functional decoupling. These results suggest that visually elicited phobic reactions activate object recognition areas and deactivate prefrontal areas involved in cognitive control over emotion-triggering areas like the amygdala, resulting in motor readiness to support fight or flight.

  • 246906.
    Åhs, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
    Rosén, Jörgen
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Kastrati, Granit
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
    Fredrikson, Mats
    Uppsala University. Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
    Ågren, Thomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Lundstrom, Johan N.
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden;Monell Chem Senses Ctr, 3500 Market St, Philadelphia, PA 19104 USA;Univ Penn, Dept Psychol, 3815 Walnut St, Philadelphia, PA 19104 USA.
    Biological preparedness and resistance to extinction of skin conductance responses conditioned to fear relevant animal pictures: A systematic review2018In: Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, E-ISSN 1873-7528, Vol. 95, p. 430-437Article, review/survey (Refereed)
    Abstract [en]

    Preparedness theory is one of the most influential ideas in explaining the origin of specific phobias. The theory proposes that fear conditioning is selective to animals that have posed a threat to survival throughout human evolution, and that acquired fear memories to such threats are resistant to extinction. We reviewed fear conditioning studies testing whether autonomic responses conditioned to pictures of snakes and spiders show greater resistance to extinction than neutral cues. We identified 32 fear conditioning experiments published in 23 studies including 1887 participants. Increased resistance to extinction of conditioned responses to snake and spider pictures was found in 10 (31%) of the experiments, whereas 22 (69%) experiments did not support the hypothesis. Thus, the body of evidence suggests that preparedness theory does not explain the origin of specific phobias.

  • 246907.
    Åhs, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Modality of measurement and power, a comparison between rCBF, psychophysiology and self assessment measures2006In: Biol. Psychiatry 59, 40S-40S, 2006Conference paper (Other academic)
  • 246908.
    Åhs, Karl-Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Framtagande av ny höjdmätningsmetod till försvarets antennhiss 8612012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This bachelor degree project was carried out at Saab AB Service and Repair, Arboga, Sweden. The objective was to design, construct and implement a new stable and reliable method of measuring the continuous vertical displacement (height) of the military search radar PS861 mounted on a hydraulic powered elevator. The end product needs to be durable enough to be fully operational in the harsh environment of an outdoor elevator shaft and yet as accurate and precise as possible since one of its purposes is to calibrate control equipment. Previously used technique has proven not to meet any of the above mentioned properties.

    A prototype using a high resolution quadrature output rotary encoder has been developed, allowing a completely digital interface. This new method has been evaluated in laboratory environment where tests have been conducted regarding both reliability and validity. The tests show that the new digital system provides highly improved accuracy and precision and in addition to that, the sensor with its IP-64 classification ensures operation even in the worst conditions. The technology developed in this project is also versatile and may be used in other situations where rotational motions are to be measured. Real life tests have not yet been carried out, but future test results will determine whether the product will replace the old system or not. 

  • 246909. Åhsberg, Elizabeth
    et al.
    Carlsson, Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy.
    Practical care work and existential issues in palliative care: experiences of nursing assistants.2013In: International Journal of Older People Nursing, ISSN 1748-3735, E-ISSN 1748-3743, Vol. 9, no 4, p. 298-305Article in journal (Refereed)
  • 246910.
    Åhsberg, Elizabeth
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. Natl Board Hlth & Welf, S-10630 Stockholm, Sweden..
    Fahlstrom, Gunilla
    Natl Board Hlth & Welf, S-10630 Stockholm, Sweden..
    Ronnback, Eva
    Granberg, Ann-Kristin
    Natl Board Hlth & Welf, S-10630 Stockholm, Sweden..
    Almborg, Ann-Helene
    Natl Board Hlth & Welf, S-10630 Stockholm, Sweden..
    Development of an Instrument for Assessing Elder Care Needs2017In: Research on social work practice, ISSN 1049-7315, E-ISSN 1552-7581, Vol. 27, no 3, p. 291-306Article in journal (Refereed)
    Abstract [en]

    Objective: To construct a needs assessment instrument for older people using a standardized terminology (International classification of functioning, disability, and health [ICF]) and assess its psychometrical properties. Method: An instrument was developed comprising questions to older people regarding their perceived care needs. The instrument's reliability, validity, and utility were tested. Forty-one social workers and 251 older people participated. Results: The questions were sufficiently unambiguous (inter-rater reliability, intraclass correlation = .60-.80); measured a person's care and service needs to a satisfactory extent (criteria validity, agreement between social workers' and older people's assessments = 72-94%); both social workers and older people considered the questions useful; and the needs of older people were documented in social records to a greater extent when the instrument was used. Conclusion: The psychometric properties of the instrument support its use by social workers to gain relevant information on elder care needs.

  • 246911.
    Åhsgren, Erik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Ek, Oscar
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Marknadsföring i Sociala Medier: En kvalitativ studie av marknadsföring i sociala mediers särdrag och skillnader emot traditionell marknadsföring2009Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Under de senaste åren har det utvecklats en rad nya applikationer på internet, så kallade sociala medier, där användare kan interagera med varandra på ett sätt som tidigare inte varit möjligt. Antalet användare av sociala medier, ökar ständigt och företag börjar inse potentialen att använda dem i sin marknadsföring. Syftet med denna uppsats var att undersöka och förklara hur marknadsföring i sociala medier skiljer sig från traditionell marknadsföring samt hur de olika delarna av sociala medier kan användas i marknadsföringsprocessen. För att kunna göra detta har vi samlat in och studerat både primär och sekundär kvalitativ data. Primär data har vi erhållit genom intervjuer med tre personer som dagligen arbetar med marknadsföring inom sociala medier. Sekundär data har samlats från böcker och artiklar. Resultatet från vår undersökning visar att det finns stora skillnader mellan marknadsföring i sociala medier och traditionell marknadsföring. Den viktigaste skillnaden är att marknadsföringen sker genom en dialog istället för en monolog. Sociala medier erbjuder företag möjligheten att interagera med sina konsumenter på ett nytt sätt. Sociala medier kan även användas av företag för att få information om produktutveckling, konsumentnöjdhet och segmentering på ett smidigare och billigare sätt än med traditionella medier.

  • 246912.
    Åke Eriksson, Margareta Högberg, Ingegerd Bäcklund, Christina Gustafsson
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Education.
    Independent Work - That's how it is. Students' comprehension of realisation and examination of the independent work1999Report (Other scientific)
  • 246913.
    Åke Eriksson, Margareta Högberg, Ingegerd Bäcklund, Christina Gustafsson
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Languages, Department of English.
    Masterpiece or Nightmare? Students' attitudes to Examination of the Independent Work1998Report (Other scientific)
  • 246914.
    Åke Eriksson, Margareta Högberg, Ingegerd Bäcklund, Christina Gustafsson
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Languages, Department of English.
    The Degree Project - Examination and Realization1997Report (Other scientific)
  • 246915.
    Åke, Saldeen
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Law, Department of Law.
    Fastställande av faderskap1980Book (Other scientific)
  • 246916.
    Åke, Saldeen
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Minor amendments and statutory proposals: Brussels II, same-sex adoption and other matters2003In: The international survey of family law. 2003 / [ed] Andrew Bainham, Bristol: Family law , 2003, , p. 411 ffChapter in book (Other academic)
  • 246917.
    Åke, Viberg
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Whole and broken: Breaking and cutting in Swedish from a crosslinguistic perspective.2007In: Communication, action, meaning: a festschrift to Jens Allwood, Göteborg: Department of Linguistics, Göteborg University , 2007, p. 17-42Chapter in book (Other academic)
    Abstract [en]

    This paper presents a brief account of major lexicalization patterns of breaking and cutting events (jointly called disconnection) in Swedish, based on a general model (meaning matrix) of the disconnection situation. The place of Swedish in a general lexical typology of disconnection is sketched on the basis of data from a couple of non-European languages and corpus-based contrastive analysis of a number of genetically and/or areally closely related languages.

  • 246918.
    Åke, Viberg
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Languages, Department of Linguistics and Philology. Lingvistik.
    •Wordnets, Framenets and Corpus-based Contrastive Lexicology.2007In: FRAME 2007: Building frame semantics resources for Scandinavian and Baltic languages. NODALIDA 2007, 2007, p. 1-10Conference paper (Refereed)
  • 246919.
    Åkeli, Alexandra
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Musicology.
    Att sjunga i damkör: En studie om damkör som social och musikalisk företeelse med fokus på Uppsalakören La Cappella2013Student paper other, 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This essay discusses sentiments underlying choices to sing in women's choir. The focus is on the female choir La Cappella from Uppsala, which is run at a professional level to constitute one of the premier choirs in the country. The La Cappella members and their conductor participated in a survey with questions about how they view their own role as a singer or conductor in a choir. The questions that this paper is based on are the following: Why choose to sing in the choir? How do the Community and the social network between women affect their decision to sing in a women´s choir? Has the sound of the chorus played an important role in the choice of choir? Interwoven in the text, I discuss and compare La Cappella with choir Flora, a Finnish-Swedish women's choir.

  • 246920.
    Åkeli, Alexandra
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature.
    Here comes Peppi Langstrømpe!: En studie om berättelseskildringen av Pippi Långstrump i översättningar till engelska, finska och norska2013Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Litteraturvetenskap, Astrid Lindgren, Pippi Långstrump

  • 246921.
    Åkerberg, Anna
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Renström, Emma
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Ett småföretags utveckling av marknadskommunikation; med fokus på valet av kommunikationsverktyg: en undersökning av småföretaget Primateria AB2008Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 246922.
    Åkerberg, Frida
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Women as a ‘conduit of policy’? -­ A study of women as recipients of cash-­based interventions aimed at improving food security at the household level in Southern Somalia.2014Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • 246923.
    Åkerberg, Helena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Functional Studies of the Neuropeptide Y System: Receptor-Ligand Interaction and Regulation of Food Intake2009Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The members of the mammalian neuropeptide Y family, i.e. the peptides neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP), are all involved in regulation of food intake. In human and most other mammals they act via receptors Y1, Y2, Y4 and Y5. NPY is released in the hypothalamus and is one of the strongest appetite-stimulating neurotransmitters whereas PP and PYY are secreted from gut endocrine cells after meals and function as appetite-reducing hormones. This thesis describes studies of the NPY system at both the molecular and the physiological level. The first part describes two investigations of receptor-ligand interactions with the human Y1 and Y2 receptors. The results clarify the importance of several amino-acid residues of the human Y1 receptor. Three amino acids previously suggested by others to form a binding pocket for the carboxy-terminus of the peptide were confirmed to be crucial for interaction with peptide ligands. However, they were found to be too distantly located from each other to be able to form a binding pocket. Further investigation of the three corresponding positions in the human Y2 receptor showed that only one of the positions was important for interaction with full-length peptides. The results indicate overlapping but, surprisingly, non-identical binding of the different peptides to human Y1 and Y2 receptors, despite the fact that the two receptors share a common ancestor. The second part of the thesis describes an investigation of the effect of PP on food intake in six beagle dogs and a test for personality characteristics in dogs (TFPC). Treatment with physiological doses of PP decreased both the appetitive and the consummatory drive but had no effect on the amount food consumed. The TFPC protocol was used to map individual behavioral differences in a population of sixteen beagle dogs. The test, which included several situations that may appear in an experimental study, revealed considerable inter-individual differences in behavioral responses despite the fact that the dogs were born and housed in the same animal facility in constant controlled conditions. These results demonstrate that PP can influence food intake in distantly related mammals and emphasize the importance of considering differences in personality in experimental animals.

    List of papers
    1. Re-evaluation of receptor–ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study
    Open this publication in new window or tab >>Re-evaluation of receptor–ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study
    Show others...
    2006 (English)In: Biochemical Journal, ISSN 0264-6021, E-ISSN 1470-8728, Vol. 1, no 393, p. 161-169Article in journal (Refereed) Published
    Abstract [en]

    Interactions of the human NPY (neuropeptide Y) receptor Y1 with the two endogenous agonists NPY and peptide YY and two non-peptide antagonists were investigated using site-directed mutagenesis at 17 positions. The present study was triggered by contradictions among previously published reports and conclusions that seemed inconsistent with sequence comparisons across species and receptor subtypes. Our results show that Asp287, at the border between TM (transmembrane) region 6 and EL3 (extracellular loop 3) influences peptide binding, while two aspartic residues in EL2 do not, in agreement with some previous studies but in disagreement with others. A hydrophobic pocket of the Y1 receptor consisting of Tyr100 (TM2), Phe286 (TM6) and His298 (EL3) has been proposed to interact with the amidated C-terminus of NPY, a theory that is unsupported by sequence comparisons between Y1, Y2 and Y5. Nevertheless, our results confirm that these amino acid residues are critical for peptide binding, but probably interact with NPY differently than proposed previously. Studies with the Y1-selective antagonist SR120819A identified a new site of interaction at Asn116 in TM3. Position Phe173 in TM4 is also important for binding of this antagonist. In contrast with previous reports, we found that Phe173 is not crucial for the binding of BIBP3226, another selective Y1 receptor antagonist. Also, we found that position Thr212 (TM5) is important for binding of both antagonists. Our mutagenesis results and our three-dimensional model of the receptor based on the high-resolution structure of bovine rhodopsin suggest new interactions for agonist as well as antagonist binding to the Y1 receptor.

    Keywords
    BIBP3226, G-protein-coupled receptor (GPCR), mutagenesis, neuropeptide Y (NPY), receptor Y1, three-dimensional model
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-97977 (URN)10.1042/BJ20050708 (DOI)16097949 (PubMedID)
    Available from: 2009-01-30 Created: 2009-01-30 Last updated: 2017-12-14Bibliographically approved
    2. Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions
    Open this publication in new window or tab >>Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions
    Show others...
    2010 (English)In: Regulatory Peptides, ISSN 0167-0115, E-ISSN 1873-1686, Vol. 163, no 1-3, p. 120-129Article in journal (Refereed) Published
    Abstract [en]

    Neuropeptide Y (NPY) and peptide YY (PYY) share similar to 70% of their 36 amino acids and bind to the same three human receptor subtypes, Y1, Y2 and Y5, even though these receptors only share similar to 30% sequence identity Based on our previous investigation of human Y1 we describe here a mutagenesis study of three corresponding positions in human Y2, i e Tyr(2 64), Val(6 58) and Tyr(7 31) Pharmacological characterization was performed with the four peptide agonists PYY, NPY, PYY(3-36) and NPY(13-36) as well as the non-peptide antagonist BIIE0246 Results from mutants where Tyr(2 64) has been substituted by Ala suggest that Tyr(2 64) is involved in the interaction with all investigated ligands whereas position Tyr(7 31) seems to be more important for interaction with the truncated peptide PYY(3-36) than with intact NPY Surprisingly, substitution of Tyr(7 31) with His, the corresponding residue in Y1, resulted in total loss of binding of iodinated porcine PYY The third position. Val(6 58), did not influence binding of any of the ligands. These findings differ from those obtained for Y1 where Ala substitution resulted in lost or changed binding for each of the three positions. Although Tyr(2 64) and Tyr(7 31) in Y2 are involved in ligand binding, their interactions with the peptide ligands seem to be different from the corresponding positions in Y1 This suggests that the receptor-ligand interactions have changed during evolution after Y1 and Y2 arose from a common ancestral receptor.

    Keywords
    Site-directed mutagenesis, G-protein coupled receptor, Three dimensional model, Evolution
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-135756 (URN)10.1016/j.regpep.2010.04.011 (DOI)000280050000018 ()
    Note

    Manuscript title: Investigation of receptor-ligand interactions of the human neuropeptide Y receptor Y2 by site-directed mutagenesis: comparison with the structurally divergent Y1 subtype

    Available from: 2010-12-08 Created: 2010-12-08 Last updated: 2017-12-11Bibliographically approved
    3. Peripheral administration of pancreatic polypeptide inhibits components of food- intake behavior in dogs
    Open this publication in new window or tab >>Peripheral administration of pancreatic polypeptide inhibits components of food- intake behavior in dogs
    Show others...
    2010 (English)In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 31, no 6, p. 1055-1061Article in journal (Refereed) Published
    Abstract [en]

    Pancreatic polypeptide (PP) belongs to the neuropeptide Y (NPY) family of peptides and is released from pancreatic F cells postprandially. PP functions as a peptide hormone and has been associated with decreased food intake in humans and rodents. Our study describes the effects of PP on feeding behavior in dogs, whose mammalian order (Carnivora) is more distantly related to primates and rodents than these are to each other. Furthermore, obesity is becoming more prevalent in dogs which makes knowledge about their appetite regulation highly relevant. Repeated peripheral administration of physiological doses of PP (three injections of 30 pmol/kg each that were administered within 30 min) to six male beagle dogs prolonged the median time spent eating three servings of food by 19% but resulted in no reduction of food intake. In addition, PP decreased the duration of food-seeking behavior after the first serving by 71%. Thus, a physiological dose of PP seems to decrease both the appetitive and the consummatory drive in dogs.

    Keywords
    Pancreatic polypeptide, Appetite, Satiety, Feeding, Food intake, Dog
    National Category
    Biological Sciences
    Identifiers
    urn:nbn:se:uu:diva-147123 (URN)10.1016/j.peptides.2010.03.019 (DOI)000283939000009 ()20338207 (PubMedID)
    Available from: 2011-02-24 Created: 2011-02-24 Last updated: 2017-12-11Bibliographically approved
    4. A Test for Personality Characteristics in Dogs
    Open this publication in new window or tab >>A Test for Personality Characteristics in Dogs
    Show others...
    Manuscript (Other academic)
    Identifiers
    urn:nbn:se:uu:diva-97980 (URN)
    Available from: 2009-01-30 Created: 2009-01-30 Last updated: 2010-01-13Bibliographically approved
  • 246924.
    Åkerberg, Helena
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Fällmar, Helena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Sjödin, Paula
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Boukharta, Lars
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
    Gutierrez-de-Teran, Hugo
    Lundell, Ingrid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Mohell, Nina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Larhammar, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions2010In: Regulatory Peptides, ISSN 0167-0115, E-ISSN 1873-1686, Vol. 163, no 1-3, p. 120-129Article in journal (Refereed)
    Abstract [en]

    Neuropeptide Y (NPY) and peptide YY (PYY) share similar to 70% of their 36 amino acids and bind to the same three human receptor subtypes, Y1, Y2 and Y5, even though these receptors only share similar to 30% sequence identity Based on our previous investigation of human Y1 we describe here a mutagenesis study of three corresponding positions in human Y2, i e Tyr(2 64), Val(6 58) and Tyr(7 31) Pharmacological characterization was performed with the four peptide agonists PYY, NPY, PYY(3-36) and NPY(13-36) as well as the non-peptide antagonist BIIE0246 Results from mutants where Tyr(2 64) has been substituted by Ala suggest that Tyr(2 64) is involved in the interaction with all investigated ligands whereas position Tyr(7 31) seems to be more important for interaction with the truncated peptide PYY(3-36) than with intact NPY Surprisingly, substitution of Tyr(7 31) with His, the corresponding residue in Y1, resulted in total loss of binding of iodinated porcine PYY The third position. Val(6 58), did not influence binding of any of the ligands. These findings differ from those obtained for Y1 where Ala substitution resulted in lost or changed binding for each of the three positions. Although Tyr(2 64) and Tyr(7 31) in Y2 are involved in ligand binding, their interactions with the peptide ligands seem to be different from the corresponding positions in Y1 This suggests that the receptor-ligand interactions have changed during evolution after Y1 and Y2 arose from a common ancestral receptor.

  • 246925.
    Åkerberg, Helena
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
    Meyerson, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
    Sallander, Marie
    Lagerstedt, Anne-Sofie
    Hedhammar, Åke
    Larhammar, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
    Peripheral administration of pancreatic polypeptide inhibits components of food- intake behavior in dogs2010In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 31, no 6, p. 1055-1061Article in journal (Refereed)
    Abstract [en]

    Pancreatic polypeptide (PP) belongs to the neuropeptide Y (NPY) family of peptides and is released from pancreatic F cells postprandially. PP functions as a peptide hormone and has been associated with decreased food intake in humans and rodents. Our study describes the effects of PP on feeding behavior in dogs, whose mammalian order (Carnivora) is more distantly related to primates and rodents than these are to each other. Furthermore, obesity is becoming more prevalent in dogs which makes knowledge about their appetite regulation highly relevant. Repeated peripheral administration of physiological doses of PP (three injections of 30 pmol/kg each that were administered within 30 min) to six male beagle dogs prolonged the median time spent eating three servings of food by 19% but resulted in no reduction of food intake. In addition, PP decreased the duration of food-seeking behavior after the first serving by 71%. Thus, a physiological dose of PP seems to decrease both the appetitive and the consummatory drive in dogs.

  • 246926.
    Åkerberg, Helena
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Wilsson, Erik
    Sallander, Marie
    Hedhammar, Åke
    Lagerstedt, Anne-Sofie
    Larhammar, Dan
    Meyerson, Bengt
    A Test for Personality Characteristics in DogsManuscript (Other academic)
  • 246927.
    Åkerberg, Helena
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Wilsson, Erik
    Sallander, Marie
    Hedhammar, Åke
    Lagerstedt, Anne-Sofie
    Larhammar, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
    Meyerson, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
    Test for personality characteristics in dogs used in research2012In: Journal of Veterinary Behavior: Clinical Applications and Research, ISSN 1558-7878, E-ISSN 1878-7517, Vol. 7, no 6, p. 327-338Article in journal (Refereed)
    Abstract [en]

    The great variation in morphological phenotypes displayed by dogs offers not only excellent opportunities for genetic analyses but also a challenge regarding between-breed and even within-breed variation. Also, behavioral responses may vary between individuals, and are to be taken into account in experimental situations. To our knowledge, no standardized test for scoring personality characteristics (TFPC) in dogs maintained for research under controlled conditions has yet been developed. The present article describes a protocol consisting of 9 test situations that are likely to arise in experimental contexts. The intent was to establish an easy-to-use standardized test protocol. Sixteen beagles were used, all housed in constant and controlled conditions. The results revealed considerable individual differences in response to certain stimuli. The largest within-group variation was found when being caged; the responses varied from passivity to escape attempts (score range: 2-5 in a 5-step scale). Substantial variation was also seen in locomotion and food consumption after exposure to stress (score range: 1-5 in a 5-step scale). In a new environment, the females showed more frequent changes in attention (focusing) compared with males (P < 0.01). There was an age-related reaction to sudden sounds (Spearman r sp = -0.52, P < 0.05). We also describe application of the TFPC to a study of food intake in response to pancreatic polypeptide performed with 6 of the male dogs. A within-group rank-order procedure was used, and interesting correlations between personality characteristics and food intake behavior were identified. We discuss how the TFPC may contribute to improvement of experimental studies in dogs.

  • 246928.
    Åkerblad, AC
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Bengtsson, F
    Ekselius, L
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    von Knorring, L
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Effects of an educational compliance enhancement programme and therapeutic drug monitoring on treatment adherence in depressed patients managed by general practitioners.2003In: Int Clin Psychopharmacol , Vol. 18, p. 347-Article in journal (Refereed)
  • 246929.
    Åkerblad, AC
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. psykiatri, UAS.
    Bengtsson, F
    von Knorring, L
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. psykiatri, UAS.
    Ekselius, L
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. psykiatri, UAS.
    Response, remission and relapse in relation to adherence in primary care treatment of depression: a 2-year outcome study.2006In: Int Clin Psychopharmacol, Vol. 21, no 2, p. 117-124Article in journal (Refereed)
  • 246930.
    Åkerblad, Ann-Charlotte
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Adherence to Antidepressant Medication2007Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Non-adherence to medication is a major obstacle in the treatment of depression. The objectives of the present study were to explore the effect of two interventions aiming to increase antidepressant treatment adherence, and to examine long-term consequences and costs of depression in adherent and non-adherent primary care patients.

    A randomised controlled design was used to assess the respective effects of a written educational adherence enhancing programme and therapeutic drug monitoring in patients with major depression treated with sertraline for 24 weeks. All patients were prospectively followed during two years.

    Treatment adherence was found in 41% of the 1031 included patients. None of the interventions resulted in a significant increase in adherence rate. However, significantly more patients in the group receiving the written educational material had responded at week 24 as compared to patients in the control group.

    The overall remission rate after two years was 68%. In total, 34% of the responders experienced at least one relapse. Response and remission rates at week 24, year 1 and year 2 were significantly higher in adherent as compared to non-adherent patients. No relationship between adherence and relapse rate was seen.

    The mean total cost per patient during two years was KSEK 363 whereof indirect costs represented 87%. No significant differences in costs between intervention groups or between adherent and non-adherent patients could be demonstrated. However, the mean cost per patient was 39% lower for treatment responders as compared to non-responders.

    Non-adherence was predicted by age below 35 or above 64 years, no concomitant medications, personality disorder, sensation seeking personality traits and substance abuse.

    The results indicate a strong positive relationship between treatment adherence and clinical outcome. In addition, the study shows that depression is a costly disease and that certain patient characteristics predict non-adherence.

    List of papers
    1. Effects ofan educational compliance enhancement programme and therapeutic drug monitoring on treatment adherence in depressed patients managed by general practitioners
    Open this publication in new window or tab >>Effects ofan educational compliance enhancement programme and therapeutic drug monitoring on treatment adherence in depressed patients managed by general practitioners
    2003 In: International Clinical Psychopharmacology, ISSN 0268-1315, Vol. 18, no 6, p. 347-354Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-95630 (URN)
    Available from: 2007-03-29 Created: 2007-03-29Bibliographically approved
    2. Response, remission and relapse in relation to adherence in primary care treatment of depression: a 2-year outcome study
    Open this publication in new window or tab >>Response, remission and relapse in relation to adherence in primary care treatment of depression: a 2-year outcome study
    2006 In: International Clinical Psychopharmacology, ISSN 0268-1315, Vol. 21, no 2, p. 117-124Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-95631 (URN)
    Available from: 2007-03-29 Created: 2007-03-29Bibliographically approved
    3. Cost of depression: effect of adherence and treatment response
    Open this publication in new window or tab >>Cost of depression: effect of adherence and treatment response
    Show others...
    2006 (English)In: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 21, no 6, p. 349-354Article in journal (Refereed) Published
    Abstract [en]

    Objectives: The purpose of the present study has been to assess the societal cost of major depression and the distribution into different cost components. The impact of adherence and treatment response was also explored.

    Method: Data were collected from a randomized controlled trial of patients with major depressive disorder who were treated in a naturalistic primary care setting. Resource use and quality of life were followed during the two-year trial.

    Results: The mean total cost per patient during two years was KSEK 363 (EUR 38 953). Indirect costs were the most important component (87%), whereas the cost of drugs was minor (4.5%). No significant differences in costs or quality of life between treatment arms or between adherent and non-adherent patients were demonstrated. However, treatment responders had 39% lower total costs per patient and experienced a larger increase in quality of life compared to non-responders.

    Conclusions: Major depression has high costs for society, primarily due to indirect costs. Treatment responders have considerably lower costs per patient and higher quality of life than non-responders. This indicates that measures to increase response rates are also important from an economic perspective.

    Keywords
    depression, cost of illness, quality of life, compliance, adherence, response
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-95632 (URN)10.1016/j.eurpsy.2006.04.005 (DOI)000241090600001 ()16777385 (PubMedID)
    Available from: 2007-03-29 Created: 2007-03-29 Last updated: 2017-12-14Bibliographically approved
    4. Predictors of non-adherence to antidepressant treatment in primary care
    Open this publication in new window or tab >>Predictors of non-adherence to antidepressant treatment in primary care
    Show others...
    Manuscript (Other academic)
    Identifiers
    urn:nbn:se:uu:diva-95633 (URN)
    Available from: 2007-03-29 Created: 2007-03-29 Last updated: 2010-01-13Bibliographically approved
  • 246931.
    Åkerblad, Ann-Charlotte
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Bengtsson, Finn
    Ekselius, Lisa
    von Knorring, Lars
    Effects ofan educational compliance enhancement programme and therapeutic drug monitoring on treatment adherence in depressed patients managed by general practitioners2003In: International Clinical Psychopharmacology, ISSN 0268-1315, Vol. 18, no 6, p. 347-354Article in journal (Refereed)
  • 246932.
    Åkerblad, Ann-Charlotte
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Bengtsson, Finn
    Holgersson, Margareta
    von Knorring, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Ekselius, Lisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Identificatin of primary care patients at risk of nonadherence to antidepressant treatment2008In: Patient Preference and Adherence, ISSN 1177-889X, Vol. 2, p. 379-386Article in journal (Refereed)
    Abstract [en]

    INTRODUCTION: Poor adherence to antidepressant treatment is common, and results in increased disability and costs. Several factors are thought to influence patients' ability and willingness to adhere. So far, however, consensus is lacking regarding patient characteristics that predict nonadherence. The purpose of this study was to identify predictors of nonadherence to antidepressant treatment that can be ascertained at treatment start. METHOD: The present study used data from a randomized controlled trial with the main objective of studying the effect of two different compliance-enhancing programs on treatment adherence and treatment response in 1031 primary care patients with major depression. In this study, logistic regression analyses were performed to examine patient- and illness-related characteristics potentially associated with nonadherence. RESULTS: Nonadherence to antidepressant treatment was predicted by age under 35 or over 64 years, presence of personality disorder, sensation-seeking personality traits, substance abuse, and absence of concomitant medications. CONCLUSION: Certain patient- and illness-related characteristics may imply an increased risk of nonadherence to antidepressant treatment. Giving special attention to subjects with such characteristics may improve adherence.

  • 246933.
    Åkerblad, Ann-Charlotte
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Bengtsson, Finn
    Holgersson, Margareta
    von Knorring, Lars
    Ekselius, Lisa
    Predictors of non-adherence to antidepressant treatment in primary careManuscript (Other academic)
  • 246934.
    Åkerblad, Ann-Charlotte
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Bengtsson, Finn
    von Knorring, Lars
    Ekselius, Lisa
    Response, remission and relapse in relation to adherence in primary care treatment of depression: a 2-year outcome study2006In: International Clinical Psychopharmacology, ISSN 0268-1315, Vol. 21, no 2, p. 117-124Article in journal (Refereed)
  • 246935.
    Åkerblad, Henrik
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Business Studies.
    Liljeblad, Rickard
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Business Studies.
    MiFID - Mycket att leva upp till?: En uppsats om Markets in Financial Instruments Directive2007Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Sammanfattning

    MiFID, direktiv om marknader för finansiella instrument är ett nytt europeiskt regelverk för den finansiella sektorn som träder i kraft den 1: a november 2007. Direktivet syftar till att förstärka konkurrenskraften för den finansiella sektorn, förbättra konsumentskyddet samt inkludera hela utbudet av finansiella tjänster och produkter. Då MiFID: s införlivande i svenska lag försenades fick de svenska värdepappersföretagen under 2007 en relativt kort tidsperiod på sig att anpassa sina verksamheter till de nya bestämmelserna. Syftet med denna uppsats är att undersöka vilka svårigheter tre svenska värdepappersföretag erfarit vid arbetet med att anpassa deras verksamheter till de nya bestämmelserna i MiFID. Vi har studerat direktivet och jämfört med nuvarande regleringar samt genomfört fyra intervjuer, varav tre med svenska värdepappersföretag av varierande storlek. Genom vår undersökning har vi funnit att särskilt två områden varit besvärliga för våra respondenter, orderhanteringen och kundkategoriseringen.

    Abstract

    MiFID, the Markets in Financial Instruments Directive is a new European regulation for the financial service industry which comes in to effect on 1 November 2007. The purpose of the directive is to strengthen the competitiveness of the financial sector, improve consumer protection and include all financial services and products. Because the implementation of MiFID into Swedish law was delayed the Swedish securities firms were given a relatively short period of time during 2007 to adapt their businesses to the regulations in MiFID.

    The purpose of our thesis is to examine what difficulties three Swedish securities firms have experienced making their businesses compliant with the new regulations in MiFID. We have studied MiFID and compared it with Swedish regulations and carried through four interviews, three with Swedish securities firms of different size. Through our research we have found that client order handling and client categorisation were experienced as troublesome areas.

  • 246936.
    Åkerbladh, Linda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Palladium(0)-Catalysed Carbonylative Multicomponent Reactions: Synthesis of Heterocycles and the Application of Quinolinyl Pyrimidines as Enzyme Inhibitors2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Palladium-catalysed carbonylative multicomponent reactions have proven useful for the synthesis of structurally diverse compounds. Carbon monoxide serves as an atom-efficient, one-carbon building block, which allows for further structural elaboration of the carbonyl compound. By varying the components of the carbonylative multicomponent reaction, considerable product diversity can readily be attained. However, due to the reluctance to use toxic CO gas, considerable efforts have been directed at exploring non-gaseous approaches. The work described in this thesis has mainly focused on the development of palladium(0)-catalysed, carbonylative multicomponent synthetic methodology, using the non-gaseous CO source molybdenum hexacarbonyl, in the synthesis of heterocycles and other biologically relevant functional groups.

    The first part of this work describes the development of a non-gaseous carbonylative Sonogashira cross-coupling of bifunctional ortho-iodoanilines and terminal alkynes. Where 4-quinolones were synthesised via a carbonylation/cyclisation sequence. Using a similar synthetic strategy, three different N-cyanobenzamide intermediates were prepared by palladium-catalysed carbonylative couplings of various aryl halides and bromides and cyanamide. The formed intermediates provided a basis for further chemical transformations. First, ortho-iodoanilines were carbonylatively coupled with cyanamide and subsequently cyclised to yield heterocyclic 2-aminoquinazolinones. Next, building on those findings, the same synthetic strategy was applied to ortho-halophenols to provide a highly convenient domino carbonylation/cyclisation method for the preparation of benzoxazinones. The developed method was used to evaluate the efficiency of various non-gaseous CO sources. Third, the palladium-catalysed carbonylative synthesis of N-cyanobenzamides, was used to produce biologically relevant N-acylguanidines with considerable product diversity. Finally, one of the developed carbonylative methodologies was used in the preparation of potential NDH-2 inhibitors based on a quinolinyl pyrimidine scaffold. The prepared compounds were biologically evaluated in terms of inhibition of oxidoreductase NDH-2 and antibacterial activity on Gram-negative bacteria, S. aureus and Mtb. The biological evaluation revealed that some of the quinolinyl pyrimidines exerted inhibitory activity on the NDH-2 enzyme and possessed antibacterial properties.

    The work described in this thesis has been devoted to the development of non-gaseous one-pot, multicomponent carbonylation/cyclisation and carbonylation/amination reactions. The described methods offer highly attractive synthetic strategies that can be of great value to synthetic and medicinal chemists.

    List of papers
    1. Synthesis of 4-Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source
    Open this publication in new window or tab >>Synthesis of 4-Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source
    Show others...
    2015 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 80, no 3, p. 1464-1471Article in journal (Refereed) Published
    Abstract [en]

    A palladium-catalyzed CO gas-free carbonylative Sonogashira/cyclization sequence for the preparation of functionalized 4-quinolones from 2-iodoanilines and alkynes via two different protocols is described. The first method (A) yields the cyclized products after only 20 min of microwave (MW) heating at 120 degrees C. The second method (B) is a gas-free one-pot two-step sequence which runs at room temperature, allowing the use of sensitive substituents (e.g., nitro and bromide groups). For both protocols, molybdenum hexacarbonyl was used as a solid source of CO.

    National Category
    Chemical Sciences
    Identifiers
    urn:nbn:se:uu:diva-249019 (URN)10.1021/jo502400h (DOI)000349934600019 ()25575042 (PubMedID)
    Available from: 2015-04-24 Created: 2015-04-10 Last updated: 2017-12-04Bibliographically approved
    2. Synthesis of 2-Aminoquinazolinones via Carbonylative Coupling of ortho-lodoanilines and Cyanamide
    Open this publication in new window or tab >>Synthesis of 2-Aminoquinazolinones via Carbonylative Coupling of ortho-lodoanilines and Cyanamide
    2016 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 81, no 7, p. 2966-2973Article in journal (Refereed) Published
    Abstract [en]

    Herein, we describe a convenient and efficient synthesis of 2-aminoquinazolin-4(3H)-ones and N1-substituted 2-aminoquinazolin-4(1H)-ones by a domino carbonylation/cyclization process. The reaction proceeds via carbonylative coupling of readily available ortho-iodoanilines with cyanamide followed by in situ ring closure of an N-cyanobenzamide intermediate. The products were easily isolated by precipitation in moderate to excellent yields for a wide range of substrates, making this a highly attractive method for the synthesis of 2-aminoquinazolinones.

    National Category
    Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-295556 (URN)10.1021/acs.joc.6b00249 (DOI)000373520200028 ()26967689 (PubMedID)
    Available from: 2016-06-22 Created: 2016-06-08 Last updated: 2017-11-28Bibliographically approved
    3. Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide
    Open this publication in new window or tab >>Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide
    2017 (English)In: ChemistryOpen, ISSN 2191-1363, Vol. 6, no 5, p. 620-628Article in journal (Refereed) Published
    Abstract [en]

    A mild and convenient one-step preparation of 4H-1,3-benzoxazin-4-ones by a domino carbonylation-cyclization process is developed. Readily available ortho-iodophenols are subjected to palladium-catalyzed carbonylative coupling with Mo(CO)(6) and cyanamide, followed by a spontaneous, intramolecular cyclization to afford 4H-1,3-benzaxazin-4-ones in moderate to excellent yields. Furthermore, the scope of the reaction is ex tended to include challenging orthobromophenols. Finally, to highlight the versatility of the developed method, Mo(CO), is successfully replaced with a wide array of CO-releasing reagents, such as oxalyl chloride, phenyl formate, 9-methylfluorene-9-carbonyl chloride, and formic acid, making this an appealing strategy for the synthesis of 4H-benzo[e][1,3]oxazin-4-ones.

    National Category
    Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-329967 (URN)10.1002/open.201700130 (DOI)000413038400003 ()29046856 (PubMedID)
    Available from: 2017-09-24 Created: 2017-09-24 Last updated: 2018-02-05Bibliographically approved
    4. Palladium(0)-Catalyzed Carbonylative Synthesis of N-Acylguanidines
    Open this publication in new window or tab >>Palladium(0)-Catalyzed Carbonylative Synthesis of N-Acylguanidines
    (English)In: Article in journal (Other academic) Submitted
    National Category
    Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-329968 (URN)
    Available from: 2017-09-24 Created: 2017-09-24 Last updated: 2017-09-24
    5. Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
    Open this publication in new window or tab >>Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
    Show others...
    (English)In: Article in journal (Other academic) Submitted
    National Category
    Medicinal Chemistry
    Identifiers
    urn:nbn:se:uu:diva-329969 (URN)
    Available from: 2017-09-24 Created: 2017-09-24 Last updated: 2018-01-13
  • 246937.
    Åkerbladh, Linda
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Chow, Shiao Y.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Odell, Luke R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Larhed, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide2017In: ChemistryOpen, ISSN 2191-1363, Vol. 6, no 5, p. 620-628Article in journal (Refereed)
    Abstract [en]

    A mild and convenient one-step preparation of 4H-1,3-benzoxazin-4-ones by a domino carbonylation-cyclization process is developed. Readily available ortho-iodophenols are subjected to palladium-catalyzed carbonylative coupling with Mo(CO)(6) and cyanamide, followed by a spontaneous, intramolecular cyclization to afford 4H-1,3-benzaxazin-4-ones in moderate to excellent yields. Furthermore, the scope of the reaction is ex tended to include challenging orthobromophenols. Finally, to highlight the versatility of the developed method, Mo(CO), is successfully replaced with a wide array of CO-releasing reagents, such as oxalyl chloride, phenyl formate, 9-methylfluorene-9-carbonyl chloride, and formic acid, making this an appealing strategy for the synthesis of 4H-benzo[e][1,3]oxazin-4-ones.

  • 246938.
    Åkerbladh, Linda
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Lu, Lu
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
    Konda, Konda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Cao, Sha
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Vocat, Anthony
    Maes, Louis
    Cole, Stewart T.
    Hughes, Diarmaid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Larhed, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Brandt, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Karlén, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Mowbray, Sherry
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
    Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)In: Article in journal (Other academic)
  • 246939.
    Åkerbladh, Linda
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Nordeman, Patrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Wejdemar, Matyas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Odell, Luke R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Larhed, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Synthesis of 4-Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source2015In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 80, no 3, p. 1464-1471Article in journal (Refereed)
    Abstract [en]

    A palladium-catalyzed CO gas-free carbonylative Sonogashira/cyclization sequence for the preparation of functionalized 4-quinolones from 2-iodoanilines and alkynes via two different protocols is described. The first method (A) yields the cyclized products after only 20 min of microwave (MW) heating at 120 degrees C. The second method (B) is a gas-free one-pot two-step sequence which runs at room temperature, allowing the use of sensitive substituents (e.g., nitro and bromide groups). For both protocols, molybdenum hexacarbonyl was used as a solid source of CO.

  • 246940.
    Åkerbladh, Linda
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Odell, Luke R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Synthesis of 2-Aminoquinazolinones via Carbonylative Coupling of ortho-lodoanilines and Cyanamide2016In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 81, no 7, p. 2966-2973Article in journal (Refereed)
    Abstract [en]

    Herein, we describe a convenient and efficient synthesis of 2-aminoquinazolin-4(3H)-ones and N1-substituted 2-aminoquinazolin-4(1H)-ones by a domino carbonylation/cyclization process. The reaction proceeds via carbonylative coupling of readily available ortho-iodoanilines with cyanamide followed by in situ ring closure of an N-cyanobenzamide intermediate. The products were easily isolated by precipitation in moderate to excellent yields for a wide range of substrates, making this a highly attractive method for the synthesis of 2-aminoquinazolinones.

  • 246941.
    Åkerbladh, Linda
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preparative Medicinal Chemistry.
    Odell, Luke R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preparative Medicinal Chemistry.
    Larhed, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preparative Medicinal Chemistry.
    Palladium-Catalyzed Molybdenum Hexacarbonyl-Mediated Gas-Free Carbonylative Reactions2019In: Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, ISSN 0936-5214, E-ISSN 1437-2096, Vol. 30, no 2, p. 141-155Article in journal (Refereed)
    Abstract [en]

    This account summarizes Pd(0)-catalyzed Mo(CO) 6-mediated gas-free carbonylative reactions published in the period October 2011 to May 2018. Presented reactions include inter-and intramolecular carbonylations, carbonylative cross-couplings, and carbonylative multicomponent reactions using Mo(CO) 6 as a solid source of CO. The presented methodologies were developed mainly for small-scale applications, avoiding the problematic use of gaseous CO in a standard laboratory. In most cases, the reported Mo(CO) 6-mediated carbonylations were conducted in sealed vials or by using two-chamber solutions. 1 Introduction 2 Recent Developments 2.1 New CO Sources 2.2 Two-Chamber System for ex Situ CO Generation 2.3 Multicomponent Carbonylations 3 Carbonylations with N and O Nucleophiles 4 Carbonylative Cross-Coupling Reactions with Organometallics 5 Carbonylative Cascade Reactions 6 Carbonylative Cascade, Multistep Reactions 7 Summary and Outlook

  • 246942.
    Åkerbladh, Linda
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preparative Medicinal Chemistry.
    Schembri, Luke S
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preparative Medicinal Chemistry.
    Larhed, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preparative Medicinal Chemistry.
    Odell, Luke R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preparative Medicinal Chemistry.
    Palladium(0)-Catalyzed Carbonylative One-Pot Synthesis of N-Acylguanidines2017In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 82, no 23, p. 12520-12529Article in journal (Refereed)
    Abstract [en]

    A convenient synthetic strategy toward N-acylguanidines via a sequential one-pot multicomponent carbonylation/amination reaction has been developed. The compounds were readily obtained via an N-cyanobenzamide intermediate formed from the Pd(0)-catalyzed carbonylative coupling of cyanamide and aryl iodides or bromides. Subsequent amination with a large variety of amines provided the final N-acylguanidines, with the overall formation of one C-C and two C-N bonds, in moderate to excellent yields. The substrate scope was found to be wide and the methodology was used to produce over 50 compounds, including 29 novel molecules. Furthermore, three separate nitrogen-containing heterocycles were prepared from the N-acylguanidines synthesized using the developed multicomponent, carbonylative method.

  • 246943.
    Åkerbladh, Linda
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Schembri, Luke S
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Larhed, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Odell, Luke R
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Palladium(0)-Catalyzed Carbonylative Synthesis of N-AcylguanidinesIn: Article in journal (Other academic)
  • 246944.
    Åkerblom, Anna
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Ghossn, Fahime
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Motiverande samtals inverkan på diabetespatienter2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: The number of people with diabetes in the world is constantly increasing. Bad food habits increase the risk of diabetes complications. Healthcare has a responsibility to enhance the patient's motivation and ability for self-care.

    Objective: Investigate the impact of MI as a treatment to help patients with diabetes to better self-care.

    Method: Literature review. The search for articles were made in the medical databases Pubmed , Cinahl and Scopus. The study included 10 original articles of which five were medium and five high quality. These were divided into two groups, effect on HbA1c and blood lipids and effect on self-care.

    Results: Based on the included studies, no significant effect is demonstrated in HbA1c and blood lipids or current diet, physical activity or medical adherence. There was however a positive effect in measurements of perceived competence, knowledge and self-control. One study demonstrates a positive effect on HbA1c of MI in combination with CBT. The effects found subsided shortly after the treatment sessions ended. Study design and measurement methods were questioned.

    Conclusion: Few studies exist in the field, therefore, it is too early to yet recommend the MI-method in diabetes care. More research is needed on MI with a clearer focus on the interviewers relationship with the patient and the MI skills of the interviewers if one aims to measure the effect of the MI-sessions.

  • 246945.
    Åkerblom, Annica
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    Fiskenäringen i Blekinge län efter 19451986Student paper second term, 5 credits / 7,5 HE creditsStudent thesis
  • 246946.
    Åkerblom, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    Arbetarskydd för kvinnor: Kvinnlig yrkesinspektion i Sverige 1913-19481998Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This dissertation deals with the Female Factory Inspectorate in Sweden 1913-1948. Its creation and activities and its approach to women and women's work are analysed from a genderperspective. The creation of a Female Factory Inspectorate was a consequence of industrialisation and subsequent changes in society and should be seen as part of the growing welfarestate in Sweden.

    The Female Factory Inspectorate was established after many years of campaigning byphilanthropic organisations and the feminist movement to arouse public opinion. The newinspectorate meant an institutionalisation of differences between men and women. The workat the Female Factory Inspectorate was concerned with questions of a social nature, such aseducation or morality, in contrast to that of the General Factory Inspectorate which focusedon technical questions. When the Female Factory Inspectorate was dissolved in 1948, theintention was to integrate the social questions into the General Factory Inspectorate.

    The Female Factory Inspectorate in Sweden had a pivotal position, having much contactwith workers, male as well as female, employers, civil servants and organisations. The inspectorate was thus able to influence legislation affecting women workers.

    In this thesis, the organisation of the Female Factory Inspectorate, its employees and itscharacteristics are explained and its development from a philanthropically-based organisationto a public authority is described. In the description and analysis of the practice of the femaleinspectorate, it becomes clear that the focus of its work was on the everyday life at the work-places. With this work the Female Factory Inspectorate contributed to the construction andreconstruction of female (industrial) workers.

  • 246947.
    Åkerblom, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Economic History.
    Införandet av kvinnlig yrkesinspektion.1990Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • 246948.
    Åkerblom, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Economic History.
    Underordning och flexibilitet (Subordination and Flexibility)1999In: Kvinnor i butik, kvinnor på fabrik. Tio vittnesbörd från arbetslivet kommenterade av fyra forskare, 1999Chapter in book (Other scientific)
  • 246949.
    Åkerblom, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Economic History.
    Vardag på jobbet! Rapport från fyra arbetsplatser i Sverige (Every Day Life at Work. Reports from Four Working Places in Sweden)1999Collection (editor) (Other scientific)
  • 246950.
    Åkerblom, Annika
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Economic History.
    Humlesjö, Inger
    Ekonomisk historia, akademiska miljöer och kvinnliga forskare (Economic History, Academic Milieu and Female Resarchers)1996In: Kvinnovetenskaplig tidskrift, no 2Article in journal (Refereed)
4936493749384939494049414942 246901 - 246950 of 249970
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf