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  • 247001.
    Yumin, Xiao
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    Robustness of the Likelihood Ratio Test for Periodicity in Short Time Series and Application to Gene Expression Data2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • 247002.
    YUN, H
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    LEE, ML
    MARKIDES, KE
    CHARCOAL POROUS LAYER OPEN-TUBULAR COLUMN GAS-CHROMATOGRAPHY FOR PERMANENT GAS-ANALYSIS1995In: JOURNAL OF MICROCOLUMN SEPARATIONS, ISSN 1040-7685, Vol. 7, no 3, p. 207-212Article in journal (Refereed)
    Abstract [en]

    The preparation of charcoal porous layer open tabular (PLOT) columns, and their application to the separation of permanent gases and light hydrocarbons are reported. Two types of charcoal, coconut and darco charcoal, were used to prepare columns from fus

  • 247003. Yun, Sining
    et al.
    Hagfeldt, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Ma, Tingli
    Pt-Free Counter Electrode for Dye-Sensitized Solar Cells with High Efficiency2014In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 26, no 36, p. 6210-6237Article in journal (Refereed)
    Abstract [en]

    Dye-sensitized solar cells (DSSCs) have attracted widespread attention in recent years as potential cost-effective alternatives to silicon-based and thin-film solar cells. Within typical DSSCs, the counter electrode (CE) is vital to collect electrons from the external circuit and catalyze the I-3(-) reduction in the electrolyte. Careful design of the CEs can improve the catalytic activity and chemical stability associated with the liquid redox electrolyte used in most cells. In this Progress Report, advances made by our groups in the development of CEs for DSSCs are reviewed, highlighting important contributions that promise low-cost, efficient, and robust DSSC systems. Specifically, we focus on the design of novel Pt-free CE catalytic materials, including design ideas, fabrication approaches, characterization techniques, first-principle density functional theory (DFT) calculations, ab-initio Car-Parrinello molecular dynamics (CPMD) simulations, and stability evaluations, that serve as practical alternatives to conventional noble metal Pt electrodes. We stress the merits and demerits of well-designed Pt-free CEs, such as carbon materials, conductive polymers, transition metal compounds (TMCs) and their corresponding hybrids. Also, the prospects and challenges of alternative Pt catalysts for their applications in new-type DSSCs and other catalytic fields are discussed.

  • 247004. Yun, Sining
    et al.
    Hagfeldt, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Ma, Tingli
    Superior Catalytic Activity of Sub-5 mu m-Thick Pt/SiC Films as Counter Electrodes for Dye-Sensitized Solar Cells2014In: ChemCatChem, ISSN 1867-3880, E-ISSN 1867-3899, Vol. 6, no 6, p. 1584-1588Article in journal (Refereed)
    Abstract [en]

    Dye-sensitized solar cells with sub-5 mu m-thick Pt/SiC-P (1.79 at.% Pt), Pt/SiC-M (0.45 at.% Pt), and Pt/SiC-R (0.39 at.% Pt) counter electrode (CE) films fabricated by using three different processes produced power conversion efficiencies of 6.82, 7.64, and 7.04% that reached 86.5, 97.0, and 89.3 %, respectively, of the level obtained by using a print-Pt CE (7.88 %). These materials can reduce the cost of CEs and solve challenges involving Pt.

  • 247005. Yun, Sining
    et al.
    Pu, Haihui
    Chen, Junhong
    Hagfeldt, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Ma, Tingli
    Enhanced Performance of Supported HfO2 Counter Electrodes for Redox Couples Used in Dye-Sensitized Solar Cells2014In: ChemSusChem, ISSN 1864-5631, E-ISSN 1864-564X, Vol. 7, no 2, p. 442-450Article in journal (Refereed)
    Abstract [en]

    Mesoporous-graphitic-carbon-supported HfO2 (HfO2-MGC) nanohybrids were synthesized by using a soft-template route. Characterization and a systematic investigation of the catalytic properties, stability, and catalytic mechanism were performed for HfO2-MGC counter electrodes (CEs) in dye-sensitized solar cells (DSSCs). The new HfO2-MGC as a CE in DSSCs showed a surprisingly high efficiency of 7.75% for the triiodide/iodide redox couple and 3.69% for the disulfide/thiolate redox couple, greater than the Pt electrode in the corresponding electrolyte system, which opens up a possibility for its practical application.

  • 247006. Yun, Sining
    et al.
    Wu, Mingxing
    Wang, Yudi
    Shi, Jing
    Lin, Xiao
    Hagfeldt, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Ma, Tingli
    Pt-like Behavior of High-Performance Counter Electrodes Prepared from Binary Tantalum Compounds Showing High Electrocatalytic Activity for Dye-Sensitized Solar Cells2013In: ChemSusChem, ISSN 1864-5631, E-ISSN 1864-564X, Vol. 6, no 3, p. 411-416Article in journal (Refereed)
  • 247007. Yun, Sining
    et al.
    Zhang, Hong
    Pu, Huihai
    Chen, Junhong
    Hagfeldt, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Ma, Tingli
    Metal Oxide/Carbide/Carbon Nanocomposites: In Situ Synthesis, Characterization, Calculation, and their Application as an Efficient Counter Electrode Catalyst for Dye-Sensitized Solar Cells2013In: Advanced Engergy Materials, ISSN 1614-6832, Vol. 3, no 11, p. 1407-1412Article in journal (Refereed)
  • 247008.
    Yun, Y.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Rusz, Jan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Suzuki, M. -T
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Oppeneer, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    First-principles investigation of higher oxides of uranium and neptunium: U3O8 and Np2O52011In: Physical Review B. Condensed Matter and Materials Physics, ISSN 1098-0121, E-ISSN 1550-235X, Vol. 83, no 7, p. 075109-Article in journal (Refereed)
    Abstract [en]

    A computational study is presented of the structural, electronic, and magnetic properties of U3O8 and Np2O5, which are actinide oxides in a higher oxidation state than the tetravalent state of the common dioxide phases, UO2 and NpO2. The calculations are based on the density functional theory +U approach, in which additional Coulomb correlations on the actinide atom are taken into account. The calculated properties of these two higher oxidized actinide oxides are analyzed and compared to those of their tetravalent analogs. The optimized structural parameters of these noncubic oxides are found to be in reasonable agreement with available experimental data. U3O8 is predicted to be a magnetic insulator, having one U atom in a hexavalent oxidation state and two U atoms in a pentavalent oxidation state. For Np2O5, which is also predicted to be an insulator, a complicated noncollinear magnetic structure is computed, leading to a nonzero overall magnetization with a slight antiferromagnetic canting. The calculated electronic structures are presented and the variation of the U 5f or Np 5f-O 2p hybridization with the oxidation state is analyzed. With increasing oxygen content, the nearly localized 5f electrons of the actinide elements are more positioned near the Fermi level and the hybridization between 5f and 2p states is markedly increased.

  • 247009.
    Yun, Younsuk
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science.
    Eriksson, Olle
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science.
    Oppeneer, Peter M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science.
    First-principles modeling of He-clusters in UO22009In: Journal of Nuclear Materials, ISSN 0022-3115, E-ISSN 1873-4820, Vol. 385, no 1, p. 72-74Article in journal (Refereed)
    Abstract [en]

    We have investigated the behavior of He in UO2, Using the projector-augmented-wave (PAW) method and the generalized gradient approximation (GGA) based on the density functional theory. Total energy calculations with atomic relaxation included have been performed in a 96-atom large supercell. We have found that He has a strong tendency to form a cluster in vicinity of an octahedral interstitial site (OIS) in the UO2 matrix. In addition, the strain energy produced by a He-cluster was found to be sufficient to create point defects of the host atoms in UO2. Our study suggests that He-clusters and He-induced point defects play an important role for the local mechanical properties Of UO2 (C) 2008 Elsevier B.V. All rights reserved.

  • 247010.
    Yun, Younsuk
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science.
    Eriksson, Olle
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science.
    Oppeneer, Peter M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science.
    Theory of He trapping, diffusion, and clustering in UO22009In: Journal of Nuclear Materials, ISSN 0022-3115, E-ISSN 1873-4820, Vol. 385, no 3, p. 510-516Article in journal (Refereed)
    Abstract [en]

    We have performed ab initio total energy calculations to investigate the behavior of helium and its diffusion properties in uranium dioxide MOD. Our investigations are based on the density functional theory within the generalized gradient approximation (GGA). The trapping behavior of He in UO2 has been modeled with a supercell containing 96-atoms as well as uranium and oxygen vacancy trapping sites. The calculated incorporation energies show that for He a uranium vacancy is more stable than an oxygen vacancy or an octahedral interstitial site (OIS). Interstitial site hopping is found to be the rate-determining mechanism of the He diffusion process and the corresponding migration energy is computed as 2.79 eV at 0 K (with the spin-orbit coupling (SOC) included), and as 2.09 eV by using the thermally expanded lattice parameter of UO2 at 1200 K, which is relatively close to the experimental value of 2.0 eV. The lattice expansion coefficient of He-induced swelling of UO2 is calculated as 9 x 10(-2). For two He atoms, we have found that they form a dumbbell configuration if they are close enough to each other, and that the lattice expansion induced by a dumbbell is larger than by two distant interstitial He atoms. The clustering tendency of He has been studied for small clusters of up to six He atoms. We find that He strongly tends to cluster in the vicinity of an OIS, and that the collective action of the He atoms is sufficient to spontaneously create additional point defects around the He cluster in the UO2 lattice. (C) 2008 Elsevier B.V. All rights reserved.

  • 247011.
    Yun, Younsuk
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science.
    Eriksson, Olle
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science.
    Oppeneer, Peter M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science.
    Kim, Hanchul
    Park, Kwangheon
    First-principles theory for helium and xenon diffusion in uranium dioxide2009In: Journal of Nuclear Materials, ISSN 0022-3115, E-ISSN 1873-4820, Vol. 385, no 2, p. 364-367Article in journal (Refereed)
    Abstract [en]

    The diffusion properties of He and Xe in UO2 have been investigated, using density-functional calculations employing the projector-augmented-wave (PAW) method and the generalized gradient approximation (GGA). The migration energies corresponding to both interstitial and vacancy-assisted mechanisms have been calculated and the results for the two noble gas atoms are compared with each other. We suggest that He likely diffuses by hopping through a single vacancy with computed low migration energies smaller than 0.79 eV and its diffusivity is much higher than that of Xe. Xe has a quite large migration energy compared to He; the strain energy plays a key role in Xe diffusion in UO2.

  • 247012.
    Yun, Younsuk
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science.
    Kim, Hanchul
    Kim, Heemoon
    Park, Kwangheon
    Atomic diffusion mechanism of Xe in UO22008In: Journal of Nuclear Materials, ISSN 0022-3115, E-ISSN 1873-4820, Vol. 378, no 1, p. 40-44Article in journal (Refereed)
    Abstract [en]

    We have investigated vacancy-assisted diffusion of Xe in uranium dioxide MOO calculating incorporation, binding, and migration energies. All the energy values have been obtained using the density functional theory (DFT) within the generalized gradient approximation (GGA) and the projector-augmented-wave (PAW) method. Considering spin-polarization effect, we find that the computed migration energy is reduced by and agrees well with experimental data compared to those obtained from nonmagnetic calculations. We also find that an oxygen vacancy lowers the migration energy of a uranium vacancy by about 1 eV, enhancing an effective movement of vacancy clusters consisting of both uranium and oxygen vacancies. Furthermore, the strain energy of Xe is large enough to contribute to the clustering of vacancies making it the driving force for the vacancy-assisted diffusion of Xe in UO2. In summary all the calculated results suggest that the trivacancy is a major diffusion pathway of Xe in UO2.

  • 247013.
    Yun, Younsuk
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Legut, Dominik
    Oppeneer, Peter M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Phonon spectrum, thermal expansion and heat capacity of UO2 from first-principles2012In: Journal of Nuclear Materials, ISSN 0022-3115, E-ISSN 1873-4820, Vol. 426, no 1-3, p. 109-114Article in journal (Refereed)
    Abstract [en]

    We report first-principles calculations of the phonon dispersion spectrum, thermal expansion, and heat capacity of uranium dioxide. The so-called direct method, based on the quasiharmonic approximation, is used to calculate the phonon frequencies within a density functional framework for the electronic structure. The phonon dispersions calculated at the theoretical equilibrium volume agree well with experimental dispersions. The computed phonon density of states (DOSs) compare reasonably well with measured data, as do also the calculated frequencies of the Raman and infrared active modes including the LO/TO splitting. To study the pressure dependence of the phonon frequencies we calculate phonon dispersions for several lattice constants. Our computed phonon spectra demonstrate the opening of a gap between the optical and acoustic modes induced by pressure. Taking into account the phonon contribution to the total free energy of UO2 its thermal expansion coefficient and heat capacity have been computed from first-principles. Both quantities are in good agreement with available experimental data for temperatures up to about 500 K. 

  • 247014. Yun, Younsuk
    et al.
    Oppeneer, Peter M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    First-principles design of next-generation nuclear fuels2011In: MRS bulletin, ISSN 0883-7694, E-ISSN 1938-1425, Vol. 36, no 3, p. 178-184Article in journal (Refereed)
    Abstract [en]

    The behavior of nuclear fuel in a reactor is a complex phenomenon that is influenced by a large number of materials properties, which include thermomechanical strength, chemical stability, microstructure, and defects. As a consequence, a comprehensive understanding of the fuel material behavior presents a significant modeling challenge, which must be mastered to improve the efficiency and reliability of current nuclear reactors. It is also essential to the development of advanced fuel materials for next-generation reactors. Over the last two decades, the use of density functional theory (DFT) has greatly contributed to our understanding by providing profound information on nuclear fuel materials, ranging from fundamental properties of f-electron systems to thermomechanical materials properties. This article briefly summarizes the main achievements of this first-principles computational methodology as it applies to nuclear fuel materials. Also, the current status of first-principles modeling is discussed, considering existing limitations and drawbacks such as size limitation and the added complexity associated with high temperature analysis. Finally, the future role of DFT modeling in the nuclear fuels industry is put into perspective.

  • 247015.
    Yun, Younsuk
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Materials Science.
    Oppeneer, Peter M.
    Kim, Hanchul
    Park, Kwangheon
    Defect energetics and Xe diffusion in UO2 and ThO22009In: Acta Materialia, ISSN 1359-6454, E-ISSN 1873-2453, Vol. 57, no 5, p. 1655-1659Article in journal (Refereed)
    Abstract [en]

    We have performed ab initio total energy calculations to investigate the defect energetics and diffusion behavior of Xe in UO2 and ThO2 matrices. All calculations have been carried out Using density functional theory within the generalized gradient approximation and applying the projector-augmented-wave method. Our results Show that the formation and migration energies of vacancy defects are more than twice as high in ThO2 compared with UO2. Another notable difference between the two oxides is the role played by an oxygen vacancy ill the movement of a cation vacancy. An vacancy enhances the movement Of a uranium vacancy by lowering its migration energy by about 1 eV, but a similar effect is not observed in ThO2. The different behavior of cation vacancies in the two oxides strongly affects the mobility of fission gases and leads to differences in their respective diffusion behavior. We sui, est that the strong resistance against oxidation of ThO2 prevents the creation and migration of defects. and results ill a lower mobility of fission gases ill ThO2 as compared to UO2.

  • 247016. Yun, Zhihong
    et al.
    Hu, Lijuan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Virology.
    Forsman, Anna
    Uzhameckis, Dmitrijs
    Jern, Patric
    Yolken, Robert
    Torrey, R Fuller
    Blomberg, Jonas
    Individual pattern of RNA expression of human endogenous gammaretrovirus-like sequences in the human brainManuscript (Other academic)
  • 247017.
    Yung, Der-Liang
    et al.
    Tallinn Univ Technol, Dept Mech Engn, EE-19086 Tallinn, Estonia..
    Antonov, Maksim
    Tallinn Univ Technol, Dept Mech Engn, EE-19086 Tallinn, Estonia..
    Hussainova, Irina
    Tallinn Univ Technol, Dept Mech Engn, EE-19086 Tallinn, Estonia..
    Veinthal, Renno
    Tallinn Univ Technol, Dept Mech Engn, EE-19086 Tallinn, Estonia..
    Hogmark, Sture
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Composition And Structure Of Bimodal WC-Co Materials Related To Mechanical Properties And Abrasive Wear2015In: M2D2015: Proceedings Of The 6Th International Conference On Mechanics And Materials In Design, 2015, p. 655-664Conference paper (Refereed)
    Abstract [en]

    This study performs the comprehensive analysis with regards to the amount of ultrafine WC grains needed for the appropriate reinforcement of the metallic binder in WC-8Co cemented carbides. The ratio of coarse versus ultrafine WC grains in the bimodal system is examined. The goal is to investigate the balance of grain distribution to achieve overall improvement of the material's mechanical and wear properties.

  • 247018. Yung, Hong Wa
    et al.
    Atkinson, Daniel
    Campion-Smith, Tim
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Olovsson, Matts
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Charnock-Jones, D. Stephen
    Burton, Graham J.
    Differential activation of placental unfolded protein response pathways implies heterogeneity in causation of early- and late-onset pre-eclampsia2014In: Journal of Pathology, ISSN 0022-3417, E-ISSN 1096-9896, Vol. 234, no 2, p. 262-276Article in journal (Refereed)
    Abstract [en]

    Based on gestational age at diagnosis and/or delivery, pre-eclampsia (PE) is commonly divided into early-onset (<34 weeks) and late-onset (>= 34 weeks) forms. Recently, the distinction between 'placental' and 'maternal' causation has been proposed, with 'placental' cases being more frequently associated with early-onset and intrauterine growth restriction. To test whether molecular placental pathology varies according to clinical presentation, we investigated stress-signalling pathways, including unfolded protein response (UPR) pathways, MAPK stress pathways, heat-shock proteins and AMPK.. in placentae delivered by caesarean section for clinical indications at different gestational ages. Controls included second-trimester, pre-term and normal-term placentae. BeWo cells were used to investigate how these pathways react to different severities of hypoxia-reoxygenation (H/R) and pro-inflammatory cytokines. Activation of placental UPR and stress-response pathways, including P-IRE1 alpha, ATF6, XBP-1, GRP78 and GRP94, P-p38/p38 and HSP70, was higher in early-onset PE than in both late-onset PE and normotensive controls (NTCs), with a clear inflection around 34 weeks. Placentae from >= 34 weeks PE and NTC were indistinguishable. Levels of UPR signalling were similar between second-trimester and term controls, but were significantly higher in pre-term 'controls' delivered vaginally for chorioamnionitis and other conditions. Severe H/R (1/20% O-2) induced equivalent activation of UPR pathways, including P-eIF2 alpha, ATF6, P-IRE1 alpha, GRP78 and GRP94, in BeWo cells. By contrast, the pro-inflammatory cytokines TNF alpha and IL-1 beta induced only mild activation of P-eIF2 alpha and GRP78. AKT, a central regulator of cell proliferation, was reduced in the <34 weeks PE placentae and severe H/R-treated cells, but not in other conditions. These findings provide the first molecular evidence that placental stress may contribute to the pathophysiology of early-onset pre-eclampsia, whereas that is unlikely to be the case in the late-onset form of the syndrome. (c) 2014 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

  • 247019. Yung, Hong Wa
    et al.
    Atkinson, Daniel
    Olovsson, Matts
    Burton, Graham
    Molecular Evidence That Placental Pathology is More Severe in Early-Onset Compared to Late-Onset Pre-Eclampsia2012In: Placenta, ISSN 0143-4004, E-ISSN 1532-3102, Vol. 33, no 9, p. A84-A84Article in journal (Other academic)
  • 247020. Yung, Hong Wa
    et al.
    Campion-Smith, Tim
    Olovsson, Matts
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Burton, Graham
    Cell-Type Specific Activation of Unfolded Protein Response Pathways in Pre-Eclamptic Placentas2012In: Placenta, ISSN 0143-4004, E-ISSN 1532-3102, Vol. 33, no 9, p. A85-A85Article in journal (Other academic)
  • 247021. Yung, Hong Wa
    et al.
    Colleoni, Francesca
    Olovsson, Matts
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Kingdom, John
    Burton, Graham
    Placental Energy Depletion In Early-Onset Preeclanipsia: Role Of EIF2 Alpha Signalling In Mitochondrial Activity2013In: Placenta, ISSN 0143-4004, E-ISSN 1532-3102, Vol. 34, no 9, p. A85-A85Article in journal (Other academic)
  • 247022. Yung, Hong Wa
    et al.
    Olovsson, Matts
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Charnock-Jones, Steve
    Burton, Graham
    Placental Endoplasmic Reticulum (ER) Stress as a Novel Molecular Signature to Distinguish Subtypes of Pre-Eclampsia2014In: Reproductive Sciences, ISSN 1933-7191, E-ISSN 1933-7205, Vol. 21, no 3S, p. 405A-406AArticle in journal (Other academic)
  • 247023.
    Yunus, S.M. , A.K. Azad, S.-G. Eriksson, J. Eriksen, H.Rundlöf
    Uppsala University, Interfaculty Units, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, The Studsvik Neutron Research Laboratory.
    Temperature dependent magnetic characterization of the spinel system GaxCoFe1-xCrO4 (0 £ x £ 1) by neutron powder diffraction at the range 10K to 500K2003In: Physica B, Vol. 337, p. 323-Article in journal (Other scientific)
  • 247024. Yus-Díez, Jesús
    et al.
    Udina, Mireia
    Soler, Maria Rosa
    Lothon, Marie
    Nilsson, Erik
    Bech, Joan
    Sun, Jielun
    Nocturnal boundary layer turbulence regimes analysis during the BLLAST campaign2019In: Atmospheric Chemistry And Physics, Vol. 19, p. 9495-9514Article in journal (Refereed)
    Abstract [en]

    A night-time turbulence regime classification, the so-called “HOckey-Stick Transition ” (HOST) theory, proposed by Sun et al. (2012) from the Cooperative Atmosphere–Surface Exchange Study-1999 (CASES-99) is explored using data from the Boundary-Layer Late Afternoon and Sunset Turbulence (BLLAST) field campaign which took place during summer 2011 in the central French Pyrenean foothills. Results show that the HOST turbulence relationships for the BLLAST field campaign data are strongly dependent on both the meteorological and orographic features. The HOST pattern only appears for nights when a stably stratified boundary layer can be developed, corresponding to fairweather and clear-sky nights, when the flow is generated by the nearby orography, from the south and the south-east. Those flows strongly influenced by the orography may generate intermittent or enhanced turbulence. When considering the whole nocturnal dataset for these flow directions, several enhanced turbulence points are found to be associated with sudden wind speed and directional shear transitions. In contrast, flows from other directions do not reproduce the HOST relationships and the turbulence relationship is almost linear, independent of vertical temperature gradients, corresponding to flows driven by synoptic scales. In addition we identify examples of gravity waves and top-down turbulent events that lead to transitions between the turbulence regimes.

  • 247025.
    Yusnizar, Y.
    et al.
    Bogor Agr Univ IPB, Grad Sch, Bogor 16680, Indonesia.;Swedish Univ Agr Sci SLU, Dept Anim Breeding & Genet, SE-75007 Uppsala, Sweden.;Indonesian Inst Sci LIPI, Biotechnol Res Ctr, Cibinong 16912, Indonesia..
    Wilbe, Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Swedish Univ Agr Sci SLU, Dept Anim Breeding & Genet, SE-75007 Uppsala, Sweden..
    Herlino, A. O.
    Swedish Univ Agr Sci SLU, Dept Anim Breeding & Genet, SE-75007 Uppsala, Sweden..
    Sumantri, C.
    Bogor Agr Univ IPB, Fac Anim Sci, Dept Anim Prod & Technol, Bogor 16680, Indonesia..
    Noor, R. Rachman
    Bogor Agr Univ IPB, Fac Anim Sci, Dept Anim Prod & Technol, Bogor 16680, Indonesia..
    Boediono, A.
    Bogor Agr Univ IPB, Fac Vet Med, Dept Anat Physiol & Pharmacol, Bogor 16680, Indonesia..
    Andersson, Leif
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Swedish Univ Agr Sci SLU, Dept Anim Breeding & Genet, SE-75007 Uppsala, Sweden..
    Andersson, G.
    Swedish Univ Agr Sci SLU, Dept Anim Breeding & Genet, SE-75007 Uppsala, Sweden..
    Microphthalmia-associated transcription factor mutations are associated with white-spotted coat color in swamp buffalo2015In: Animal Genetics, ISSN 0268-9146, E-ISSN 1365-2052, Vol. 46, no 6, p. 676-682Article in journal (Refereed)
    Abstract [en]

    A candidate gene analysis of the microphthalmia-associated transcription factor (MITF) gene was used in an attempt to identify the genetic basis for a white-spotted coat color phenotype in the Asian swamp buffalo (Bubalus bubalis carabanensis). Ninety-three buffaloes32 solid, 38 spotted and 23 white individualswere Sanger-sequenced for all MITF exons as well as highly conserved intronic and flanking regions. MITFcDNA representing skin and iris tissue from six spotted, nine solid and one white buffaloes was also Sanger-sequenced to confirm detected mutations. Two independent loss-of-function mutations, a premature stop codon (c.328C>T, p.Arg110*) and a donor splice-site mutation (c.840+2T>A, p.Glu281_Leu282Ins8), both of which cause white-spotted coat color in swamp buffaloes, were identified. The nonsense mutation leads to a premature stop codon in exon 3, and likely removal of the resulting mRNA via nonsense-mediated decay pathway, whereas the donor splice-site mutation leads to aberrant splicing of exon 8 that encodes part of a highly conserved region of MITF. The resulting insertion of eight amino acid residues is expected to perturb the leucine zipper part in the basic helix-loop-helix leucine zipper (bHLH-Zip) domain and will most likely influence dimerization and DNA binding capacity. Electrophoretic mobility shift assay was performed using mutant and wild-type MITF proteins and showed that the mutant MITF protein resulting from the splice-site mutation decreased invitro DNA binding capacity compared to wild-type MITF. White-spotted buffalo bulls are sacrificed in funeral ceremonies in Tana Toraja, Indonesia, because they are considered holy, and our results show that genetic variation causes a tie to the cultural use of these buffaloes.

  • 247026. Yusof, Siti R
    et al.
    Mohd Uzid, Mahathir
    Teh, Eng-Huat
    Hanapi, Nur Aziah
    Mohideen, Mazlin
    Mohamad Arshad, Ahmad Saifuddin
    Mordi, Mohd Nizam
    Loryan, Irena
    Uppsala University, Science for Life Laboratory, SciLifeLab.
    Margareta, Hammarlund-Udenaes
    Uppsala University, Science for Life Laboratory, SciLifeLab.
    Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution:: the missing link in pharmacodynamic studies2018In: Addiction Biology, ISSN 1355-6215, E-ISSN 1369-1600Article in journal (Refereed)
    Abstract [en]

    Mitragyna speciosa is reported to be beneficial for the management of chronic pain and opioid withdrawal in the evolving opioid epidemic. Data on the blood-brain barrier (BBB) transport of mitragynine and 7-hydroxymitragynine, the active compounds of the plant, are still lacking and inconclusive. Here, we present for the first time the rate and the extent of mitragynine and 7-hydroxymitragynine transport across the BBB, with an investigation of their post-BBB intra-brain distribution. We utilized an in vitro BBB model to study the rate of BBB permeation of the compounds and their interaction with efflux transporter P-glycoprotein (P-gp). Mitragynine showed higher apical-to-basolateral (A-B, i.e. blood-to-brain side) permeability than 7-hydroxymitragynine. 7-Hydroxymitragynine showed a tendency to efflux, with efflux ratio (B-A/A-B) of 1.39. Both were found to inhibit the P-gp and are also subject to efflux by the P-gp. Assessment of the extent of BBB transport in vivo in rats from unbound brain to plasma concentration ratios (Kp,uu,brain ) revealed extensive efflux of both compounds, with less than 10 percent of unbound mitragynine and 7-hydroxymitragynine in plasma crossing the BBB. By contrast, the extent of intra-brain distribution was significantly different, with mitragynine having 18-fold higher brain tissue uptake in brain slice assay compared with 7-hydroxymitragynine. Mitragynine showed a moderate capacity to accumulate inside brain parenchymal cells, while 7-hydroxymitragynine showed restricted cellular barrier transport. The presented findings from this systematic investigation of brain pharmacokinetics of mitragynine and 7-hydroxymitragynine are essential for design and interpretation of in vivo experiments aiming to establish exposure-response relationship.

  • 247027.
    Yuspeh, Emmy
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Havelock in India as an Emerging SCUBA Diving Destination: Challenges and Opportunities2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This qualitative field study is conducted on the Andaman Islands in India and focuses on the sustainable destination development and SCUBA diving tourism. The island in focus, Havelock, is an emerging tourist destination and an international airport is scheduled to open in the Andamans in 2021. The topic is approached through observation and interviews with people involved with the SCUBA diving industry, selected informants, and diving tourists. Different scales that operate with the island’s development - global, national, regional and local - are investigated. Global warming poses a threat to the coral reefs that is the main resource for tourism at the location and the longterm residents’ education in the subject is absent. The communication between state and nation is a problem as laws are passed without participation or awareness from the local community which makes it difficult for businessowners to invest. Furthermore, diver motivation and satisfaction are investigated. The main motivation of beginner level diving tourists from India are not educated in how the underwater world looks like, but are motivated to see what they already know through movies like “Finding Nemo”. The study reveals that a degraded coral reef does not affect diver satisfaction where the divers are not educated in how a healthy reef looks like. The local Marine Protected Area - Rani Jhansi Marine National Park - is in 2019 funded by the government and there are currently no entrance fees for diving tourists. However, this has been proved successful in other destinations. The Marine Protected Area is perceived as positive by the local SCUBA industry, but it is not interacting with its regulation and governing.

  • 247028. Yusuf, Dilmurat
    et al.
    Davis, Andrew M
    Kleywegt, Gerard J
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Molecular Biology.
    Schmitt, Stefan
    An alternative method for the evaluation of docking performance: RSR vs RMSD.2008In: Journal of chemical information and modeling, ISSN 1549-9596, Vol. 48, no 7, p. 1411-1422Article in journal (Refereed)
    Abstract [en]

    A new assessment criterion for docking poses is proposed in which experimental electron density is taken into account when evaluating the ability of docking programs to reproduce experimentally observed binding modes. Three docking programs (Gold, Glide, and Fred) were used to generate poses for a set of 88 protein-ligand complexes for which the crystal structure is known. The new criterion is based on the real space R-factor (RSR), which measures how well a group of atoms-in our case the ligand-fits the experimental electron density by comparing that density to the expected density, calculated from the model (i.e., the predicted ligand pose). The RSR-based measure is compared to the traditional criterion, the root-mean-square distance (RMSD) between the docking pose and the binding configuration in the crystallographic model. The results highlight several shortcomings of the RMSD criterion that do not affect the RSR-based measure. Examples illustrate that the RSR-derived approach allows a more meaningful a posteriori assessment of docking methods and results. Practical implications for docking evaluations and for methodological development work in this field are discussed.

  • 247029.
    Yusuf, Hoodo
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Martinez Bergström, Malin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Creating legitimacy within blockchain startups in a virtual context: A study on how decentralized organizations raise funds before executing an Initial Coin Offering.2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna uppsats ämnar att undersöka de kommunikativa processer för blockedjeteknologi startups som ska lansera en så kallad “initial coin offering” och således mynta sin egna kryptovaluta, såsom till exempel bitcoin. Vi avser att undersöka det strategiska kommunikation processerna detta involverar.

    Från ena perspektivet är ett decentraliserat blockkedjesystem högt värderat på grund av det faktum att det jämställer samtliga medverkande och på så vis skapar en “perfekt demokrati”, å andra sidan argumenterar många att centralisering behövs för att bibehålla tillit. Tillit till organisationer skapas genom vetandet att det finns konsekvenser till dess handlingar som kan införas av högre auktoriteter ifall dessa handlingar faller utanför ramarna av vad som anses accepterat (De Fillipe & Wright, 2015). Utan en högre auktoritet som kan implementera detta blir tillit svårare att upprätthålla. Dock verkar blockkedjeteknologi motbevisa detta koncept. Hur är det möjligt för organisationer utan någon reglering från centrala myndigheter att skapa legitimitet och tillit för att på så sätt kunna få investeringar? Resultaten vi fann ställdes i jämförelse sig till våra tre legitimitets teorier som var kognitiv legitimitet, moral legitimitet och pragmatisk legitimitet, samt centrala teman och nyckelord. Att etablera en levande närvaro på sociala medier som till exempel Twitter, LinkedIn och framför allt Telegram grupper var mycket relevant. I telegram grupper sågs en grupp med många aktiva medlemmar och snabb svarsfrekvens från organisationen som mycket betydelsefullt, samt att ha botar som städar upp irrelevant material utan att deltagarna upplever detta som automatiserat och genuint. Att delta på event och etablera relationer med andra individer inom området och även närliggande områden som till exempel banksektorn var centralt, målet med detta var i många fall att kunna få betydelsefulla individer i sin styrelse av rådgivare vilket ökar legitimiteten. Att kunna ställa organisationens implementering av decentraliserad blockkedjeteknologi i jämförelse med den nuvarande centraliserade lösningen var essentiellt för att locka investerare som var villiga att riskera kapital för en ny modernare lösning.

  • 247030.
    Yusuf, Salim
    et al.
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada..
    Lonn, Eva
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada..
    Pais, Prem
    St Johns Res Inst, Bangalore, Karnataka, India..
    Bosch, Jackie
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Sch Rehabil Sci, Hamilton, ON, Canada..
    Lopez-Jaramillo, Patricio
    Univ Santander, Fdn Oftalmol Santander, Bucaramanga, Colombia.;Univ Santander, Inst Masira, Sch Med, Bucaramanga, Colombia..
    Zhu, Jun
    Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China..
    Xavier, Denis
    St Johns Res Inst, Bangalore, Karnataka, India.;St Johns Med Coll, Bangalore, Karnataka, India..
    Avezum, Alvaro
    Dante Pazzanese Inst Cardiol, Sao Paulo, Brazil..
    Leiter, Lawrence A.
    Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.;Univ Toronto, St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada..
    Piegas, Leopoldo S.
    HCor Heart Hosp, Sao Paulo, Brazil..
    Parkhomenko, Alexander
    Inst Cardiol, Kiev, Ukraine..
    Keltai, Matyas
    Semmelweis Univ, Hungarian Inst Cardiol, H-1085 Budapest, Hungary..
    Keltai, Katalin
    Semmelweis Univ, Hungarian Inst Cardiol, H-1085 Budapest, Hungary..
    Sliwa, Karen
    Univ Cape Town, Hatter Inst Cardiovasc Res Africa, Dept Med, Soweto Cardiovasc Res Grp, ZA-7925 Cape Town, South Africa..
    Chazova, Irina
    Inst Clin Cardiol, Russian Cardiol Res Complex, Moscow, Russia..
    Peters, Ron J. G.
    Univ Amsterdam, Acad Med Ctr, Dept Cardiol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands..
    Held, Claes
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Yusoff, Khalid
    Univ Teknologi Majlis Amansh Rakyat, Selayang, Malaysia.;Univ Coll Sedaya Int Univ, Kuala Lumpur, Malaysia..
    Lewis, Basil S.
    Technion Israel Inst Technol, Ruth & Bruce Rappaport Sch Med, Lady Davis Carmel Med Ctr, Haifa, Israel..
    Jansky, Petr
    Univ Hosp Motol, Prague, Czech Republic..
    Khunti, Kamlesh
    Univ Leicester, Diabet Res Ctr, Leicester, Leics, England..
    Toff, William D.
    Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, Natl Inst Hlth Res, Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England..
    Reid, Christopher M.
    Monash Ctr Cardiovasc Res & Educ Therapeut, Primary Care Diabet & Vasc Med, Melbourne, Vic, Australia.;Curtin Univ, Sch Publ Hlth, Perth, WA 6845, Australia..
    Varigos, John
    Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia..
    Accini, Jose L.
    Univ Norte, Barranquilla, Colombia..
    McKelvie, Robert
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada..
    Pogue, Janice
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada..
    Jung, Hyejung
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada..
    Liu, Lisheng
    Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China..
    Diaz, Rafael
    Inst Cardiovasc Rosario, Rosario, Santa Fe, Argentina..
    Dans, Antonio
    Univ Philippines, Coll Med, Manila, Philippines..
    Dagenais, Gilles
    Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada..
    Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease2016In: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 374, no 21, p. 2032-2043Article in journal (Refereed)
    Abstract [en]

    BACKGROUND Elevated blood pressure and elevated low-density lipoprotein (LDL) cholesterol increase the risk of cardiovascular disease. Lowering both should reduce the risk of cardiovascular events substantially.

    METHODS In a trial with 2-by-2 factorial design, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to rosuvastatin (10 mg per day) or placebo and to candesartan (16 mg per day) plus hydrochlorothiazide (12.5 mg per day) or placebo. In the analyses reported here, we compared the 3180 participants assigned to combined therapy (with rosuvastatin and the two antihypertensive agents) with the 3168 participants assigned to dual placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, and the second coprimary outcome additionally included heart failure, cardiac arrest, or revascularization. The median follow-up was 5.6 years.

    RESULTS The decrease in the LDL cholesterol level was 33.7 mg per deciliter (0.87 mmol per liter) greater in the combined-therapy group than in the dual-placebo group, and the decrease in systolic blood pressure was 6.2 mm Hg greater with combined therapy than with dual placebo. The first coprimary outcome occurred in 113 participants (3.6%) in the combined-therapy group and in 157 (5.0%) in the dual-placebo group (hazard ratio, 0.71; 95% confidence interval [CI], 0.56 to 0.90; P=0.005). The second coprimary outcome occurred in 136 participants (4.3%) and 187 participants (5.9%), respectively (hazard ratio, 0.72; 95% CI, 0.57 to 0.89; P=0.003). Muscle weakness and dizziness were more common in the combined-therapy group than in the dual-placebo group, but the overall rate of discontinuation of the trial regimen was similar in the two groups.

    CONCLUSIONS The combination of rosuvastatin (10 mg per day), candesartan (16 mg per day), and hydrochlorothiazide (12.5 mg per day) was associated with a significantly lower rate of cardiovascular events than dual placebo among persons at intermediate risk who did not have cardiovascular disease. (ClinicalTrials.gov number, NCT00468923.)

  • 247031. Yusuf, Salim
    et al.
    Mehta, Shamir R.
    Chrolavicius, Susan
    Afzal, Rizwan
    Pogue, Janice
    Granger, Christopher B.
    Budaj, Andrzej
    Peters, Ron J. G.
    Bassand, Jean-Pierre
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Joyner, Campbell
    Fox, Keith A. A.
    Comparison of fondaparinux and enoxaparin in acute coronary syndromes2006In: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 354, no 14, p. 1464-1476Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The combined use of anticoagulants, antiplatelet agents, and invasive coronary procedures reduces ischemic coronary events but also increases bleeding in patients with acute coronary syndromes. We therefore assessed whether fondaparinux would preserve the anti-ischemic benefits of enoxaparin while reducing bleeding. METHODS: We randomly assigned 20,078 patients with acute coronary syndromes to receive either fondaparinux (2.5 mg daily) or enoxaparin (1 mg per kilogram of body weight twice daily) for a mean of six days and evaluated death, myocardial infarction, or refractory ischemia at nine days (the primary outcome); major bleeding; and their combination. Patients were followed for up to six months. RESULTS: The number of patients with primary-outcome events was similar in the two groups (579 with fondaparinux [5.8 percent] vs. 573 with enoxaparin [5.7 percent]; hazard ratio in the fondaparinux group, 1.01; 95 percent confidence interval, 0.90 to 1.13), satisfying the noninferiority criteria. The number of events meeting this combined outcome showed a nonsignificant trend toward a lower value in the fondaparinux group at 30 days (805 vs. 864, P=0.13) and at the end of the study (1222 vs. 1308, P=0.06). The rate of major bleeding at nine days was markedly lower with fondaparinux than with enoxaparin (217 events [2.2 percent] vs. 412 events [4.1 percent]; hazard ratio, 0.52; P<0.001). The composite of the primary outcome and major bleeding at nine days favored fondaparinux (737 events [7.3 percent] vs. 905 events [9.0 percent]; hazard ratio, 0.81; P<0.001). Fondaparinux was associated with a significantly reduced number of deaths at 30 days (295 vs. 352, P=0.02) and at 180 days (574 vs. 638, P=0.05). CONCLUSIONS: Fondaparinux is similar to enoxaparin in reducing the risk of ischemic events at nine days, but it substantially reduces major bleeding and improves long term mortality and morbidity. (ClinicalTrials.gov number, NCT00139815.).

  • 247032. Yusuf, Salim
    et al.
    Mehta, Shamir R.
    Chrolavicius, Susan
    Afzal, Rizwan
    Pogue, Janice
    Granger, Christopher B.
    Budaj, Andrzej
    Peters, Ron J. G.
    Bassand, Jean-Pierre
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Joyner, Campbell
    Fox, Keith A. A.
    Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial2006In: Journal of the American Medical Association (JAMA), ISSN 0098-7484, E-ISSN 1538-3598, Vol. 295, no 13, p. 1519-1930Article in journal (Refereed)
    Abstract [en]

    CONTEXT: Despite many therapeutic advances, mortality in patients with acute ST-segment elevation myocardial infarction (STEMI) remains high. The role of additional antithrombotic agents is unclear, especially among patients not receiving reperfusion therapy. OBJECTIVE: To evaluate the effect of fondaparinux, a factor Xa inhibitor, when initiated early and given for up to 8 days vs usual care (placebo in those in whom unfractionated heparin [UFH] is not indicated [stratum 1] or unfractionated heparin for up to 48 hours followed by placebo for up to 8 days [stratum 2]) in patients with STEMI. DESIGN, SETTING, AND PARTICIPANTS: Randomized double-blind comparison of fondaparinux 2.5 mg once daily or control for up to 8 days in 12,092 patients with STEMI from 447 hospitals in 41 countries (September 2003-January 2006). From day 3 through day 9, all patients received either fondaparinux or placebo according to the original randomized assignment. MAIN OUTCOME MEASURES: Composite of death or reinfarction at 30 days (primary) with secondary assessments at 9 days and at final follow-up (3 or 6 months). RESULTS: Death or reinfarction at 30 days was significantly reduced from 677 (11.2%) of 6056 patients in the control group to 585 (9.7%) of 6036 patients in the fondaparinux group (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.77-0.96; P = .008); absolute risk reduction, 1.5%; 95% CI, 0.4%-2.6%). These benefits were observed at 9 days (537 [8.9%] placebo vs 444 [7.4%] fondaparinux; HR, 0.83; 95% CI, 0.73-0.94; P = .003, and at study end (857 [14.8%] placebo vs 756 [13.4%] fondaparinux; HR, 0.88; 95% CI, 0.79-0.97; P = .008). Mortality was significantly reduced throughout the study. There was no heterogeneity of the effects of fondaparinux in the 2 strata by planned heparin use. However, there was no benefit in those undergoing primary percutaneous coronary intervention. In other patients in stratum 2, fondaparinux was superior to unfractionated heparin in preventing death or reinfarction at 30 days (HR, 0.82; 95% CI, 0.66-1.02; P = .08) and at study end (HR, 0.77; 95% CI, 0.64-0.93; P = .008). Significant benefits were observed in those receiving thrombolytic therapy (HR, 0.79; P = .003) and those not receiving any reperfusion therapy (HR, 0.80; P = .03). There was a tendency to fewer severe bleeds (79 for placebo vs 61 for fondaparinux; P = .13), with significantly fewer cardiac tamponade (48 vs 28; P = .02) with fondaparinux at 9 days. CONCLUSION: In patients with STEMI, particularly those not undergoing primary percutaneous coronary intervention, fondaparinux significantly reduces mortality and reinfarction without increasing bleeding and strokes. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT00064428.

  • 247033.
    Yusupujiang, Zulipiye
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Using Unsupervised Morphological Segmentation to Improve Dependency Parsing for Morphologically Rich Languages2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In this thesis, we mainly investigate the influence of using unsupervised morphological segmentation as features on the dependency parsing of morphologically rich languages such as Finnish, Estonian, Hungarian, Turkish, Uyghur, and Kazakh. Studying the morphology of these languages is of great importance for the dependency parsing of morphologically rich languages since dependency relations in a sentence of these languages mostly rely on morphemes rather than word order. In order to investigate our research questions, we have conducted a large number of parsing experiments both on MaltParser and UDPipe. We have generated the supervised morphology and the predicted POS tags from UDPipe, and obtained the unsupervised morphological segmentation from Morfessor, and have converted the unsupervised morphological segmentation into features and added them to the UD treebanks of each language. We have also investigated the different ways of converting the unsupervised segmentation into features and studied the result of each method. We have reported the Labeled Attachment Score (LAS) for all of our experimental results.

    The main finding of this study is that dependency parsing of some languages can be improved simply by providing unsupervised morphology during parsing if there is no manually annotated or supervised morphology available for such languages. After adding unsupervised morphological information with predicted POS tags, we get improvement of 4.9%, 6.0%, 8.7%, 3.3%, 3.7%, and 12.0% on the test set of Turkish, Uyghur, Kazakh, Finnish, Estonian, and Hungarian respectively on MaltParser, and the parsing accuracies have been improved by 2.7%, 4.1%, 8.2%, 2.4%, 1.6%, and 2.6% on the test set of Turkish, Uyghur, Kazakh, Finnish, Estonian, and Hungarian respectively on UDPipe when comparing the results from the models which do not use any morphological information during parsing.

  • 247034.
    Yutin, Natalya
    et al.
    NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA..
    Bäckstrom, Disa
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Ettema, Thijs J G
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Krupovic, Mart
    Inst Pasteur, Dept Microbiol, Unite Biol Mol Gene Chez Extremophiles, Paris, France..
    Koonin, Eugene V.
    NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA..
    Vast diversity of prokaryotic virus genomes encoding double jelly-roll major capsid proteins uncovered by genomic and metagenomic sequence analysis2018In: Virology Journal, ISSN 1743-422X, E-ISSN 1743-422X, Vol. 15, article id 67Article in journal (Refereed)
    Abstract [en]

    Background: Analysis of metagenomic sequences has become the principal approach for the study of the diversity of viruses. Many recent, extensive metagenomic studies on several classes of viruses have dramatically expanded the visible part of the virosphere, showing that previously undetected viruses, or those that have been considered rare, actually are important components of the global virome.

    Results: We investigated the provenance of viruses related to tail-less bacteriophages of the family Tectiviridae by searching genomic and metagenomics sequence databases for distant homologs of the tectivirus-like Double JellyRoll major capsid proteins (DJR MCP). These searches resulted in the identification of numerous genomes of viruslike elements that are similar in size to tectiviruses (10-15 kilobases) and have diverse gene compositions. By comparison of the gene repertoires, the DJR MCP-encoding genomes were classified into 6 distinct groups that can be predicted to differ in reproduction strategies and host ranges. Only the DJR MCP gene that is present by design is shared by all these genomes, and most also encode a predicted DNA-packaging ATPase; the rest of the genes are present only in subgroups of this unexpectedly diverse collection of DJR MCP-encoding genomes. Only a minority encode a DNA polymerase which is a hallmark of the family Tectiviridae and the putative family "Autolykiviridae". Notably, one of the identified putative DJR MCP viruses encodes a homolog of Cas1 endonuclease, the integrase involved in CRISPR-Cas adaptation and integration of transposon-like elements called casposons. This is the first detected occurrence of Cas1 in a virus. Many of the identified elements are individual contigs flanked by inverted or direct repeats and appear to represent complete, extrachromosomal viral genomes, whereas others are flanked by bacterial genes and thus can be considered as proviruses. These contigs come from metagenomes of widely different environments, some dominated by archaea and others by bacteria, suggesting that collectively, the DJR MCP-encoding elements have a broad host range among prokaryotes.

    Conclusions: The findings reported here greatly expand the known host range of (putative) viruses of bacteria and archaea that encode a DJR MCP. They also demonstrate the extreme diversity of genome architectures in these viruses that encode no universal proteins other than the capsid protein that was used as the marker for their identification. From a supposedly minor group of bacterial and archaeal viruses, these viruses are emerging as a substantial component of the prokaryotic virome.

  • 247035.
    Yu-Xia, Ji
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Gunnar A., Niklasson
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Claes G., Granqvist
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Nanothermochromic VO2-SiO2 composite coating for energy-efficient glazingsManuscript (preprint) (Other academic)
  • 247036.
    Yu-Xia, Ji
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Mattsson, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Gunnar A., Niklasson
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Claes G., Granqvist
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Österlund, Lars
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    TiO2/VO2 bilayer coatings for glazing: Synergetically enhanced photocatalytic, thermochromic, and luminous propertiesManuscript (preprint) (Other academic)
  • 247037.
    Yu-Xia, Ji
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Shu-Yi, Li
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Gunnar A., Niklasson
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Claes-Göran, Granqvist
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Effect of Al oxide top coatings on the durability of thermochromic VO2thin films2014Conference paper (Other academic)
  • 247038. Yvon-Durocher, Gabriel
    et al.
    Allen, Andrew P.
    Bastviken, David
    Conrad, Ralf
    Gudasz, Cristian
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    St-Pierre, Annick
    Thanh-Duc, Nguyen
    del Giorgio, Paul A.
    Methane fluxes show consistent temperature dependence across microbial to ecosystem scales2014In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 507, no 7493, p. 488-491Article in journal (Refereed)
    Abstract [en]

    Methane (CH4) is an important greenhouse gas because it has 25 times the global warming potential of carbon dioxide (CO2) by mass over a century(1). Recent calculations suggest that atmospheric CH4 emissions have been responsible for approximately 20% of Earth's warming since pre-industrial times(2). Understanding how CH4 emissions from ecosystems will respond to expected increases in global temperature is therefore fundamental to predicting whether the carbon cycle will mitigate or accelerate climate change. Methanogenesis is the terminal step in the remineralization of organic matter and is carried out by strictly anaerobic Archaea(3). Like most other forms of metabolism, methanogenesis is temperature-dependent(4,5). However, it is not yet known how this physiological response combines with other biotic processes (for example, methanotrophy(6), substrate supply(3,7), microbial community composition(8)) and abiotic processes (for example, water-table depth(9,10)) to determine the temperature dependence of ecosystem-level CH4 emissions. It is also not known whether CH4 emissions at the ecosystem level have a fundamentally different temperature dependence than other key fluxes in the carbon cycle, such as photosynthesis and respiration. Here we use meta-analyses to show that seasonal variations in CH4 emissions from a wide range of ecosystems exhibit an average temperature dependence similar to that of CH4 production derived from pure cultures of methanogens and anaerobic microbial communities. This average temperature dependence (0.96 electron volts (eV)), which corresponds to a 57-fold increase between 0 and 30 degrees C, is considerably higher than previously observed for respiration (approximately 0.65 eV)(11) and photosynthesis (approximately 0.3 eV)(12). As a result, we show that both the emission of CH4 and the ratio of CH4 to CO2 emissions increase markedly with seasonal increases in temperature. Our findings suggest that global warming may have a large impact on the relative contributions of CO2 and CH4 to total greenhouse gas emissions from aquatic ecosystems, terrestrial wetlands and rice paddies.

  • 247039.
    Yxhammar, Beatrice
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Kommunikationsverktyg och dess påverkan på den interna kommunikationen inom en organisation: Ett förbättringsarbete på Briab - Brand & Riskingenjörerna AB2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The globalization and digitalisation have made information more avalible. In order to handle a huge amount of information, technical tools may be used. Within organizations, technical tools are at times used to facilitate dissemination of information. However, if the technical tools are not functioning for its purpose, the tool might insted aggravate the dissemination of information. A pilot study, accomplished at a company named Briab, showed that employeed felt unsatisfied with the technical communication-tools used within the company. Based on the result from the pilot study, this study has been done with the purpose to chart actions of impovements for the internal communcation-tools at Briab. The prospect of improved internal communication-tools was to contribute to improvement of the internal communication as a hole.

    The study was delimited to the four central communication-tools within Briab; the intranet, Briab Studio, Microsoft Teams and Microsoft Outlook. In order to achieve the purpose of the study, a survey was preformed upon the hole company. The result of the survey identified the needs for internal communication and the oponions regarding the internal communication-tools. The survey result showed that the respondents experianced defects regarding all of the internal communication-tools, yet mostly regarding the intranet and Briab Studio. The respondents did, among other, describe that to much information were not updated, that information were not mediated in a satisfying way and that the company lacked knowledge for how to communicate internally.

    Based on the results from the survey, analysis were done by the means of affinity diagrams, where the answers were categorised and the two main problems, of the respective communication-tools, were charted. In order to provide effective actions of improvements, the main causes of the problems were identified through a workshop together with representatives of the company. The main causes were identified as a lack of information-ownership, categorisation of information and guidelines for internal communication, among others. The problems with the internal communicaiton-tools generated in a lack of concern within the employees at Briab, overload of information resulted in employees missing out on important information and the lack of guidelines for internal communication opened to employees using the communication-tools in various ways. Based on the main problems, theories and the employees suggestion of improvement, an action plan of improvements was made. Through the action plan, the purpose of the study was achieved by charting actions of improvements for the internal communication-tools. Briab has been recomended to implement and follow up on the effect of the actions, in order to improve the communication-tools and hopefully improve the interal communication within the company.

  • 247040.
    Yücel, Mehmet Onur
    et al.
    Antakya Devlet Hastanesi, Psikiyatri Bl, Antakya, Turkey..
    Devrimci Özgüven, Halise
    Ankara Univ, Tip Fak, Psikiyatri AD, TR-06100 Ankara, Turkey..
    Sakarya, Ayşegül
    Kastamonu Devlet Hastanesi, Psikiyatri Bl, Kastamonu, Turkey..
    Baskak, Bora
    Ankara Univ, Tip Fak, Psikiyatri AD, TR-06100 Ankara, Turkey..
    Özel Kızıl, Erguvan Tuğba
    Ankara Univ, Tip Fak, Psikiyatri AD, TR-06100 Ankara, Turkey..
    Sakarya, Direnç
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Haran, Seda
    Serbest Calisan, Ankara, Turkey..
    The Relationship of Verbal Working Memory and Theory of Mind in First Degree Relatives of Patients With Schizophrenia and Bipolar Disorder2016In: Turk Psikiyatri Dergisi, ISSN 1300-2163, Vol. 27, no 1, p. 8-14Article in journal (Refereed)
    Abstract [tr]

    OBJECTIVE: We aimed to compare Theory of Mind (ToM) functions and investigate the relationship between ToM functions and verbal working memory (VWM) in first degree relatives of bipolar disorder and schizophrenia patients.

    METHOD: The sample consisted of first degree relatives of patients with bipolar disorder (n=22), schizophrenia (n=28), and age, gender, education and total IQ matched healthy volunteers (n=27) without a family history of schizophrenia or bipolar disorder. We administered Auditory Consonants Test (ACT) to evaluate VWM, first and second order false belief tests (ToM-1, ToM-2), Faux Pas Test (FPT), Hinting Test (HT) to evaluate different domains of ToM functions.

    RESULTS: Both relative groups performed significantly lower in all components of ToM and VWM tests compared to the control group. When VWM scores were employed as covariate in the analyses, the FPT difference between the groups remained significant, HT difference regressed to a marginal level, and the difference between ToM-1 and ToM-2 disappeared.

    CONCLUSION: To our knowledge, this is the first study indicating the presence of ToM impairment among first degree relatives of bipolar disorder patients similar to relatives of schizophrenia patients. VWM performance seems to affect first and second order ToM functions in relatives of patients with schizophrenia and bipolar disorder. On the other hand, FPT and HT domains seem to be independent of VWM performances in these groups. FPT and HT impairments may be familial vulnerability markers that are independent from neurocognitive impairment.

  • 247041.
    Yüksek, Derya
    et al.
    Vrije Universiteit Brussel, Belgium.
    Carpentier, Nico
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Participatory Contact Zones And Conflict Transformation: The Participatory Intensities Of The Cyprus Friendship Program2018In: Conjunctions: Transdisciplinary Journal of Cultural Participation, ISSN 2246-3755, Vol. 5, no 1, p. 3-21Article in journal (Refereed)
    Abstract [en]

    Despite the celebratory approach towards community participation in peace-building, less attention has been placed on the participatory process itself, leaving ambiguous how, and to what degree, power is actually redistributed in these processes. This article aims to address this gap by further developing Torre’s concept of the participatory contact zone. This notion first structures a mapping of Cypriot bi-communal education-related projects (2010-2015) and then supports an in-depth analysis of one project, the Cyprus Friendship Program (CFP). This case study uses Carpentier’s four-level, twelve-step model for participatory analysis to scrutinize the participatory intensity of the CFP’s organizational processes, focusing on the power position of the involved youngsters. It shows that teenagers participate in the CFP at varying degrees: While their power position on a more structural level is limited, there are three areas where these youngsters become more empowered: Co-organization (at lower levels), the teamwork during activities and the development of new initiatives.

  • 247042.
    Yüksel, Sirin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Information om dosering, farmakokinetik och farmakodynamik för behandling av barn med olika psykofarmaka i SmPC2017Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Information om dosering, farmakokinetik och farmakodynamik för behandling av barn med olika psykofarmaka i SmPC

    Sirin Yüksel

    Handledare: Elin Kimland, Läkemedelsverket. Examinator: Margareta Hammarlund- Udenaes, Avdelning för farmakokinetik och läkemedelsterapi, Uppsala universitet,Farmakoterapi D 30hp, Ht 2016

    Introduktion: Psykiskt ohälsa hos barn och ungdomar ökar och många psykofarmaka är inte godkända för användning till barn. Därför får barnen dessa läkemedel off-label, vilket betyder förskrivning och användning av läkemedel utanför den godkända produktinformationen, Produktresumén, SmPC (Summaryof Product Charateristics). Detta kan medföra en ökad risk att drabbas av läkemedelsrelaterade problem.

    Syfte: Syftet med projektet är att kartlägga tillgänglig information om doseringar och information om farmakokinetik/farmakodynamik för att förbättra behandlingen av barn med psykofarmaka eftersom de flesta psykofarmaka saknar dosering till barn.

    Material och metoder:Genom Socialstyrelsens läkemedelsregister sammanställdes vilka psykofarmaka som används av barn. Litteratursökning genomfördes för att identifiera bakgrund och liknande studier. Granskningen av SmPC för alla substanser som ingick i ATC-koderna, N05A, N05B, N05C, N06A och N06B insamlades som både kvalitativ och kvantitativ data. 

    Resultat: Psykostimulantia(N06B) följt av läkemedel mot sömnbesvär (N05C),ångest (N05B) och depression (N06A) var de mest förskrivna psykofarmaka. Användning av neuroleptika (N05A) var mer ovanligt. I litteratursökningen återfanns inga liknande studier. Totalt granskades 246 preparat (ADHD läkemedel exkluderades i den fortsatta analysen). För 75 % (162) av preparaten fanns ingen dosering till barn. Kommentarerna som visar att det inte finns dosering till barn har formulerats på olika sätt och även har olika betydelse.  Informationen som fanns mellan olika generika preparat skiljer sig däremot inte från varandra.

    Konklusion. För en majoritet av psykofarmaka fanns det farmakokinetik/farmakodynamik information för barn i SmPC.Hur stor klinisk betydelse denna information har kvarstår dock att ta reda på. För att förbättra behandling av barn med psykofarmaka behövs ytterligare studier på barn som presenteras i Produktresuméerna. 

  • 247043.
    Zaar, Emil
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    Finanskrisen 1990. Banker-Finansbolag-Fastighetsbolag.2014Student paper second term, 5 credits / 7,5 HE creditsStudent thesis
  • 247044.
    Zaar, Emil
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Photovoltaic power potential on Gotland: A comparison with load, wind power and power export possibilities2016Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The Swedish Island of Gotland provides an interesting case of how renewable energy technologies can be combined and integrated into the electricity system. The study simulates the load, wind power production and PV power production to estimate the PV power potential for existing buildings on Gotland. The theoretical PV power potential on Gotland is calculated to be 667 MW. The PV power potential is split between 28% for dwelling buildings, 9% for multi-dwelling buildings, 7% for industry and 56% for other buildings. The current limit for wind power on Gotland is 195 MW. With the installed capacity of 194 MW wind power, an additional of 22 MW of PV power is possible to integrate without increasing the hours of overload on the power cable. With the prospected submarine power cable, a total of 529 MW PV power is possible to integrate with the existing 194 MW of wind power.

  • 247045.
    Zaar, Harald
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Ctrl + Alt + Delete - En registrerads möjlighet att begära radering av sina personuppgifter när de behandlas av ett licensierat spelbolag2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • 247046.
    Zaar, N
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Holmberg, Lars
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Wilander, E
    Rastad, Jonas
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Survival in small intestinal adenocarcinoma1996In: Eur J Cancer, Vol. 32, p. 2114-Article in journal (Refereed)
  • 247047. Zabarovskaja, S.
    et al.
    Gadler, F.
    Gabrielsen, A.
    Hagerman, I.
    Hellgren, L.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Tornqvist, A.
    Linde, C.
    Lund, L. H.
    Screening Patients with Cardiac Resynchronization Therapy/Implantable Cardioverter-Defibrillator for Indications for Heart Transplantation and Left Ventricular Assist Device: A Pilot Study2013In: The Journal of Heart and Lung Transplantation, ISSN 1053-2498, E-ISSN 1557-3117, Vol. 32, no 4, p. S161-S161Article in journal (Other academic)
  • 247048.
    Zabel, H
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics.
    Labergerie, D
    Westerholt, K
    Hjörvarsson, Björgvin
    Tunability of the magnetic properties of nanostructures with hydrogen2001In: Invitet paper, Physics of Metals and Mettalography, Vol. 91, no Suppl.1, p. 9-14Article in journal (Other academic)
  • 247049.
    Zabel, H
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics.
    Labergierie, D
    Westerholt, K
    Hjörvarsson, Björgvin
    Tunability of thin film magnetic properties with hydrogen2001In: Physics of Metals and Metallography, Vol. 91, no Suppl. 1, p. 9-14Article in journal (Other academic)
  • 247050.
    Zabielski, Julia
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Andersson Zimdahl, Lovisa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    "Och då kom mammapoliserna": En socialpsykologisk intervjustudie om upplevelser av offentligt moderskap2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med denna studie är att få en förståelse för hur mammor, som offentliggör sitt moderskap på sociala medier, upplever sitt moderskap. Närmare bestämt avser studien besvara frågeställningar som berör vilka förväntningar som dessa mammor upplever att andra har på dem i mammarollen samt hur deras emotioner och självbild påverkas av offentliggörandet av moderskapet. Dessutom ämnar studien besvara hur mammorna upplever att de porträtterar sitt moderskap på sociala medier. Studien antar ett socialpsykologiskt perspektiv med ett teoretiskt ramverk som består av följande teorier: Goffmans dramaturgiska perspektiv, Beckers teori om sanktioner, Cooleys teori om spegeljaget, samt Shotts teori om rolltagande emotioner. I tillägg till detta introduceras vårt egna begrepp “offentligt moderskap”. Empirin har samlats in genom tio kvalitativa forskningsintervjuer och resultatet visar att mammorna upplever att mammarollen är nära förbunden med flera förväntningar: att vara med sitt barn, att ge sitt barn “rätt” kost och att ha den “rätta” utsidan. Dessa förväntningar är ibland motstridiga och orsakar en kluvenhet och ambivalens hos mammorna. Vidare upprätthålls förväntningarna genom kritiska och uppmuntrande kommentarer från läsare och följare. De kritiska kommentarerna leder till att mammorna får en negativ självbild och att de upplever emotioner såsom skam och skuld. Uppmuntrande kommentarer, från bekanta snarare än läsare och följare, leder istället till att mammorna får en positiv självbild. Bland de mammor som hade en positiv självbild var en vanligt förekommande emotion stolthet och bland de mammor som var mer osäkra på sin egen självbild förekom emotionen fåfänga. Avslutningsvis tycks mammorna porträttera sitt moderskap på olika sätt. Antingen anpassades porträtteringen till de förväntningar som de upplevde fanns på dem i deras mammaroll eller så fanns en ambition att visa upp en mer ärlig bild av moderskapet som inte nödvändigtvis stämmer överens med dessa förväntningar.

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