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  • 249601.
    Zetterström, Karin
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health.
    Lindeberg, Solveig
    Haglund, Bengt
    Hanson, Ulf
    The effect of chronic hypertension on the risk of perinatal death: - including gender aspectArticle in journal (Refereed)
  • 249602.
    Zetterström, Karin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Lindeberg, Solveig
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Haglund, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Magnuson, Anders
    Hanson, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Being born small for gestational age increases the risk of severe pre-eclampsia2007In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 114, no 3, p. 319-324Article in journal (Refereed)
    Abstract [en]

    Objective: The first aim of this study was to investigate the risk of pre-eclampsia, both mild and severe, in women born small for gestational age (SGA). The second aim was to investigate whether the risk is modified by pre-eclampsia in the previous generation. Design: Population-based cohort study. Setting: Sweden. Population: A population of 118 634 women registered both as newborns and as mothers in the Swedish Medical Birth Register of 1973-2003. Of these, 6883 had been born SGA. Only primiparas and singletons were included. Methods: The pregnancies that the women were born out of were analysed with regard to presence of pre-eclampsia, while their own pregnancies were analysed regarding age at delivery, smoking, body mass index and incidence of mild or severe pre-eclampsia. Multiple logistic regression analysis was used. In a first step, we adjusted for maternal characteristics, and in a second step, for pre-eclampsia in the previous generation. Main outcome measures: Odds ratio for mild and severe pre-eclampsia. Results: In women born SGA, the adjusted odds ratio (first step) for mild pre-eclampsia was 1.19 (95% CI 1.03-1.38), while for severe pre-eclampsia it was 1.69 (95% CI 1.40-2.02) compared with those not born SGA. After the second-step adjustment, the odds ratio for mild pre-eclampsia was 1.16 (95% CI 1.00-1.35) and for severe pre-eclampsia was 1.62 (95% CI 1.35-1.95). No statistically significant effect modification from pre-eclampsia in the previous generation was shown. Conclusions: Women born SGA suffer a markedly increased risk of severe pre-eclampsia. Exposure to pre-eclampsia during a woman's own fetal development significantly increases her risk of pre-eclampsia but does not modify the SGA effect.

  • 249603. Zetterström, Karin
    et al.
    Lindeberg, Solveig Norden
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health.
    Haglund, Bengt
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health.
    Hanson, Ulf
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health.
    Maternal complications in women with chronic hypertension: a population-based cohort study.2005In: Acta Obstet Gynecol Scand, ISSN 0001-6349, Vol. 84, no 5, p. 419-24Article in journal (Other scientific)
  • 249604.
    Zetterström, Karin
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health.
    Norden Lindeberg, Solveig
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health.
    Haglund, Bengt
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health.
    Hanson, Ulf
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health.
    Maternal complications in women with chronic hypertension: a population-based cohort study2004In: Acta Obstet Gynecol Scand, Vol. 83, p. 1-6Article in journal (Refereed)
  • 249605.
    Zetterström, Karin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Nordén Lindeberg, Solveig
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Haglund, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Hanson, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Chronic hypertension as a risk factor for offspring to be born small for gestational age2006In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 85, no 9, p. 1046-1050Article in journal (Refereed)
    Abstract [en]

    Background. Chronic hypertension during pregnancy is associated with an increased risk for birth of small for gestational age offspring. The aim of this study was to determine whether the risk remains after consideration of maternal characteristics and superimposed pre-eclampsia. Method. A population-based cohort study based on the Swedish Medical Birth Register 1992-98 and comprising 560,188 women aged 15-44 years with singleton pregnancies including 2,754 women with chronic hypertension. The register contains data of maternal characteristics besides maternal and fetal complications. Multiple logistic regression analysis was used. Small for gestational age was defined as birth weight less than -2SD adjusted for gestational age and sex. Results. Chronic hypertensive women have an independent risk for small for gestational age (OR 3.1; 95% CI 2.7-3.7) when controlling for confounding of maternal characteristics such as age, parity, BMI, smoking, and ethnical origin. After introducing superimposed pre-eclampsia in the model the risk remains but decreases (OR 2.4; 95% CI 2.1-2.9). Conclusion. Chronic hypertension is an independent risk factor for birth of small for gestational age offspring. Pre-eclampsia is a strong mediating factor.

  • 249606.
    Zetterström, Karin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Nordén-Lindeberg, Solveig
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Haglund, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Hanson, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    The association of maternal chronic hypertension with perinatal death in male and female offspring: a record linkage study of 866,188 women2008In: BJOG : an international journal of obstetrics and gynaecology, ISSN 1471-0528, Vol. 115, no 11, p. 1436-42Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: The purpose of this study was to determine whether there is a difference, by gender, in perinatal mortality in chronically hypertensive women compared with normotensive women. DESIGN: Population-based prospective cohort study. SETTING: Sweden. POPULATION: A total of 866,188 women with singleton pregnancies registered in the Swedish Medical Birth Registry 1992-2004, of which 4749 were diagnosed with chronic hypertension. METHODS: Multivariate logistic regression analysis was performed. In a first step, we adjusted for maternal characteristics and in a second step for mild and severe pre-eclampsia, gestational diabetes, placental abruption and small for gestational age. An effect modification by gender was included in the model. MAIN OUTCOME MEASURES: Odds ratios (OR) for intrauterine death, neonatal death and post-neonatal death with respect to gender of offspring. RESULTS: The unadjusted OR of intrauterine death was 4.12 (95% CI: 2.84-5.96) and 1.29 (95% CI: 0.67-2.48) for male and female offspring, respectively, and of neonatal death, it was 3.45 (95% CI: 2.13-5.59) and 2.17 (95% CI: 1.08-4.35) for male and female offspring, respectively. After multivariate analysis, the OR of intrauterine death was 3.07 (95% CI: 2.12-4.46) and neonatal death was 2.99 (95% CI: 1.84-4.85) for male offspring. For female offspring, the OR of intrauterine death was 0.98 (95% CI: 0.51-1.89) and neonatal death was 1.88 (95% CI: 0.93-3.79). CONCLUSION: Mothers with chronic hypertension have an increased risk of perinatal mortality of their male offspring.

  • 249607.
    Zetterström, Katharina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Dagvård och Reglerbart gastriskt band som behandling för patienter med fetma2010Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Introduction: Overweight and obesity is a globally growing public health problem leading to enormous economic costs for the society. Obesity surgery, including Adjustable Gastric Banding (AGB), has shown long-term positive effects on weight loss, while non-surgical obesity treatment has shown less evident effects. This has led to a dramatic increase in obesity surgery. Still, some surgery patients have difficulties in maintaining weight loss over time. The majority of experts argue that long-term treatment is essential for maintaining behavioral changes. According to experts, Daycare treatment is worth considering for patients suffering from obesity. It has been used broadly within the diabetes care though not to the same extent in obesity treatment. Aim: To structure and investigate the population and data from an already completed but unpublished three year old intervention study, with three follow ups, of weight loss and eating behavior in patients with obesity after treatment with Adjustable Gastric Banding, Daycare or a combination of the both treatments. Method: Data in 30 binders, from participants (baseline n=212) in an already completed but unpublished intervention study, was read and structured into an index in Microsoft Words. A database in Microsoft Excel was then structured were patients with specified measures for weight loss (BMI) and eating behavior (TFEQ), for one, two or three of the total three follow ups, was counted together. Results: After the structuration and investigation of the material it became evident that due to drop-out or missing data only (n=10) out of (n=212) had fulfilled the study by showing specified measures of BMI and TFEQ at every of the total three follow ups. To, in the present Master thesis, show results from a greater sample, also participants with measures (BMI, TFEQ) from baseline and the third follow up, but not necessary from the first or second follow up (n=43), was included in the presentation. BMI and TFEQ were presented in mean and median for each of the treatment groups. Conclusion: The result shows that a majority of the participants not completed the program. Hence could no effect of the treatments on changes of weight and eating behavior be rated.

  • 249608.
    Zetterström, Michelle
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Evaluation of an in vitro-model for standardized testing of endocrine disrupting chemicals and their effects on female reproduction2012Independent thesis Basic level (degree of Bachelor), 20 credits / 30 HE creditsStudent thesis
  • 249609.
    Zetterström, Olle
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
    Allergy to a detergent enzyme - subtilisin-A - in Swedish consumers 1977Doctoral thesis, comprehensive summary (Other academic)
  • 249610.
    Zetterström, P
    et al.
    Uppsala University, Interfaculty Units, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, The Studsvik Neutron Research Laboratory.
    Belushkin, AV
    McGreevy, RL
    Shuvalov, LA
    Structure and proton conduction in CsDSO41999In: SOLID STATE IONICS, ISSN 0167-2738, Vol. 116, no 3-4, p. 321-329Article in journal (Other scientific)
    Abstract [en]

    Caesium hydrogen sulphate is one of the most extensively studied superprotonic conductors with hydrogen bonds. A first order phase transition, from the low conductivity to the high conductivity phase, takes place at 414 K. The crystallographic structure o

  • 249611.
    Zetterström, P
    et al.
    Uppsala University, Interfaculty Units, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, The Studsvik Neutron Research Laboratory.
    Chahid, A
    McGreevy, RL
    Quasi-elastic and low-energy inelastic neutron scattering from fast ion conducting AgBr1999In: PHYSICA B, ISSN 0921-4526, Vol. 266, no 1-2, p. 115-120Article in journal (Other scientific)
    Abstract [en]

    An apparently anomalous low-energy mode has been observed in AgBr close to the melting point, T-m, by inelastic neutron scattering using the IN6 time-of-flight spectrometer at ILL. Further measurements using the RITA triple-axis spectrometer at Ris phi Na

  • 249612.
    Zetterström P, Dahlborg U, Delaplane R G, Howells W S
    Uppsala University.
    Neutron diffraction studies of liquid iso-propanol1991In: Physica Scripta, Vol. 44, p. 56-62Article in journal (Refereed)
    Abstract [en]

    The structure of deuterated liquid iso-propanol has been studied with neutron diffraction at the LAD diffractometer at the ISIS spallation source. Measurements were performed at temperatures 190, 220, 250 and 275 K. To correctfor inelastic effects a model

  • 249613.
    Zetterström P, Dahlborg U, Howells W S
    Uppsala University.
    A systematic study of the structure of iso-propanol by time-of-flight neutron diffraction1994In: Molecular Physics, ISSN 0026-8976, Vol. 81, no 5, p. 1187-1204Article in journal (Refereed)
    Abstract [en]

    A time of flight neutron diffraction study of liquid iso-propanol is presented. Two samples one fully and one partially deuterated were measured at three different tempratures. The inelasticeffects in the measurements were observed to have a large effect

  • 249614.
    Zetterström P, Dahlborg U, Howells W S
    Uppsala University.
    Structural studies of liquid 2-bromopropane and 2-chloropropane by neutron diffraction1994In: Molecular Physics, ISSN 0026-8976, Vol. 83, no 5, p. 971-981Article in journal (Refereed)
    Abstract [en]

    The structures of fully deuterated liquid 2-bromopropane and 2-chloropropane have been investigated by neutron diffraction. Four different temeratures were employed and a separation of 2-bromopropane into an intramolecular and an intermolecular form facto

  • 249615.
    Zetterström P, Dahlborg U, Howells W S, Carlile C
    Uppsala University.
    Molecular motions in liquid iso-propanol1992In: Recent development in the physics of fluids, , p. 291-298Conference proceedings (editor) (Other scientific)
    Abstract [en]

    The molecular motions in liquid iso-propanol have been studied by quasi elastic high-resolution neutron scattering in the IRIS spectrometer at the ISIS neutron source. The measurements where performed in the high viscosity temperature range 155 to 220 K.

  • 249616.
    Zetterström, P.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, The Studsvik Neutron Research Laboratory.
    Delaplane, R.
    Wang, Y. D.
    Liaw, P. K.
    Choo, H.
    Saksl, K.
    Zhang, H. F.
    Ren, Y.
    Zuo, L.
    Nanoscale defect clusters in metallic glasses2007In: Journal of Physics: Condensed Matter, ISSN 0953-8984, E-ISSN 1361-648X, Vol. 19, no 37, p. 376217-Article in journal (Refereed)
    Abstract [en]

    The reverse Monte Carlo method was used to obtain three-dimensional discrete distributions of constitutional atoms in melt-spun CuZr and CuZrTi metallic glasses from neutron and x-ray diffraction data. It was found that the icosahedral short-range order is less stable in the CuZr binary alloy than in the Ti-doped ternary alloy. The present investigation also provides evidence on the medium-range order, characterized by some nanoscale clusters of defects, in the metallic-glassy state.

  • 249617.
    Zetterström, P
    et al.
    Uppsala University, Interfaculty Units, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, The Studsvik Neutron Research Laboratory.
    McGreevy, R L
    Mellergård, A
    Eriksen, J
    Reorientation of anions in ion conducting sodium ortho-phosphate, a reverse Monte Carlo study of neutron diffraction data2002In: Appl. Phys. A, Vol. 75, no 1-3, p. 995-997Article in journal (Refereed)
    Abstract [en]

    Many solids containing anion groups such as SO4 2-

  • 249618.
    Zetterström, P
    et al.
    Uppsala University, Interfaculty Units, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, The Studsvik Neutron Research Laboratory.
    McGreevy, RL
    Improved Monte Carlo program MCGR, for determining G(r)2000In: PHYSICA B, ISSN 0921-4526, Vol. 276-278, p. 187-188Article in journal (Refereed)
    Abstract [en]

    The program MCGR for determining total or partial radial distribution functions from one or more total structure factors has been improved. The maximum r-value can be much higher than before without increasing the execution time too much. This is desirabl

  • 249619.
    Zetterström P, Soper A K, Schofield P
    Uppsala University.
    Inelastic neutron scattering of light and heavy water at high incident energies1997In: Molecular Physics, ISSN 0026-8976, Vol. 90, no 5, p. 773-786Article in journal (Refereed)
    Abstract [en]

    Inelastic neutron spectroscopy on pure light and heavy water and on mixtures is reported in this paper. The results are compared with calculations based on two models of the dynamic self-scattering law. Both models are connected to the mean kinetic energy

  • 249620.
    Zetterström P, Soper A K, Schofield P
    Uppsala University.
    Neutron Compton Scattering1997In: Physica B, Elsevier Science BV , 1997, Vol. 234-236, p. 337-339Conference paper (Refereed)
    Abstract [en]

    Neutron Compton scattering measurements on water (H2O and D2O) are presented. The measurements are compared with calculations of the Compton profiles based on two different models of the dynamic self-scattering law Sself(Q,omega). Both models depend

  • 249621.
    Zetterström P, Soper A K, Schofield P
    Uppsala University.
    Parametrisation of the van Hove dynamic scattering law S(Q,w)1996In: Molecular Physics, ISSN 0026-8976, Vol. 88, no 6, p. 1621-Article in journal (Refereed)
    Abstract [en]

    In this paper we present a model of the Van Hove dynamic scattering law SME(Q,omega) based on the maximum entropy principle which is developed for the first time. The model is aimed to be used in the calculation of inelastic corrections to neutron diffrac

  • 249622.
    Zetterström, Patrik
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Utökade dimensioneringskrav från en förhöjd installationsgrad av distribuerade solcellssystem2016Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This study aims to examine the hosting capacity (the maximum amount of distributed generation possible to add to a current grid) of Mälarenergi’s distribution networks. The three areas examined are a rural network, a modern suburban grid and an older suburban grid. The networks are modelled in PowerWorld Simulator with data mainly from Mälarenergi’s NIS (Network Information System). The basic models include calculated minimum loads based on load profiles, combined with 0 kW, 2 kW, 4kW or 5 kW installed photovoltaics (PV) systems at each consumer. The compensating models are based on the previous ones but with reduced transformer voltages to lower the risk of grid over-voltages. A high load case is also examined to make sure there are no under-voltages for these models.

    The results show that the rural network is strong enough to handle the biggest available PV system at 5 kW, if the transformer voltage is lowered from 1.03 p.u. to 1.005 p.u. The modern suburban grid can host 4 kW solar panels together with a lowered voltage level of 1.005 p.u. The larger package of 5 kW leads to overloading at the transformer when used. The older suburban grid has the largest issues with both overvoltages and overloading and can only handle 2 kW distributed generation with a voltage reduction to 1.005 p.u. The models are fairly sensitive because of assumed transfomer parameters and, in the case of the modern suburban grid, some lines being removed due to limitations in the software. Regardless, the results are robust enough that they can be considered correct.

  • 249623. Zetterström, R
    et al.
    Smedby, B
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Health Services Research.
    Vårdbehov och vårdeffektivitet1979In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 76, p. 711-12Article in journal (Refereed)
  • 249624.
    Zetterström, Stefan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Förvaltningsrätt2011 (ed. 1)Book (Other academic)
    Abstract [sv]

    Den här boken ger en översiktlig och lättillgänglig redogörelse för det förvaltningsrättsliga området. Vi får bland annat följa ett ärendes väg från tidpunkten då det väcks, genom t.ex. ansökan, anmälan eller ex officio, fram till det att ärendet slutligen avgörs i Högsta förvaltningsdomstolen.

  • 249625.
    Zetterström, Stefan
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Law, Department of Law.
    Juridik till vardags: Ekonomi2005In: Juridik till vardags: Ekonomi, Wahlström & Widstrand , 2005Chapter in book (Other (popular scientific, debate etc.))
  • 249626.
    Zetterström, Stefan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Juridiken och dess arbetssätt: En introduktion2012 (ed. 2)Book (Other (popular science, discussion, etc.))
    Abstract [sv]

    Juridiken och dess arbetssätt är en introduktion till juridiken och det arbetssätt juristen använder för att lösa juridiska problem. Boken behandlar bland annat frågor om

    • juristernas olika roller och uppgifter,
    • rättskällornas tillkomst och funktion,
    • metoden att tolka rättskällorna,
    • domstolarnas organisation och arbetssätt,
    • samt det juridiska språket.
  • 249627.
    Zetterström, Stefan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Konstitutionell rätt2012 (ed. 1)Book (Other academic)
    Abstract [sv]

    Konstitutionell rätt in nuce tar upp frågor om funktionsfördelningen mellan de olika aktörerna, regler om val, normgivningsmakten, finansmakten och den konstitutionella kontrollen av olika offentliga aktörer samt dessutom reglerna om mänskliga fri- och rättigheter. Bokens innehåll presenteras på ett överskådligt och lättillgängligt sätt. Läsaren orienteras genom RF:s regelsystem med textinnehåll och exempel varvat med illustrationer i form av figurer, flödesscheman och sammanfattande rutor. Vi kan på ett förenklat sätt bl.a. följa tillkomsten av en lag, från ax till limpa. Konstitutionell rätt kan användas som lärobok inom juristutbildningen, men också inom andra utbildningar/kurser som behandlar konstitutionell rätt.

  • 249628.
    Zetterström, Stefan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Offentlig rätt2011 (ed. 1)Book (Other academic)
    Abstract [sv]

    Offentlig rätt ger en samlad överblick över den offentliga rätten i Sverige. Tillsammans med systerboken Civilrätt erbjuds härmed ett komplett material för juridiska introduktionskurser. Dessutom tillgodoses behovet för fullständiga kurser i såväl civilrätt som offentlig rätt.

  • 249629.
    Zetterström, Stefan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Offentlighet och sekretess2010 (ed. 1)Book (Other academic)
    Abstract [sv]

    Allmänhetens möjlighet till insyn i den offentliga förvaltningens göromål är en viktig del av vårt rättssamhälle. En öppenhet i myndigheternas arbete och ärenden skapar en form av garanti för att myndigheterna handlägger sina ärenden och utövar sin offentliga makt med stöd i lag. Offentlighetsprincipen förverkligar bland annat allmänhetens krav på rättssäkerhet. I Offentlighet och sekretess behandlas främst handlingsoffentligheten som möjliggör allmänhetens tillgång till allmänna handlingar som förvaras hos myndigheterna. Allmänna handlingars offentlighet, som behandlas i boken, kommer främst till uttryck i tryckfrihetsförordningens 2 kap. Offentlighets- och sekretesslagen från 2009 har ersatt den tidigare gällande sekretesslagen från 1980-talet. Den nya lagstiftningen, som behandlas i boken, innehåller inte många materiella ändringar utan är mest ett resultat av redaktionella omarbetningar för att göra lagstiftningen mer lättöverskådlig och lättillämpad. Slutligen innehåller boken ett kortare avsnitt om offentlighet och sekretess i förhållande till andra stater. I huvudsak behandlas kortfattat vissa regler och principer i förhållande till EU.

  • 249630.
    Zetterström, Stefan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Sakrättens fyra huvudfall2012 (ed. 3)Book (Other (popular science, discussion, etc.))
    Abstract [sv]

    Sakrättens fyra huvudfall är en bok om allmän sakrätt avseende lös egendom. Boken behandlar frågor om godtrosförvärv, dubbeldispositioner, borgenärsskydd till utlämnad egendom samt borgenärsskydd till förvärvad egendom.

  • 249631.
    Zetterström, Stefan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Svensk avtalsrätt2014 (ed. 1)Book (Other academic)
    Abstract [sv]

    Svensk avtalsrätt är en lärobok främst avsedd för grundutbildningar i avtalsrätt, såväl inom högskolan som i privat regi. Boken kan dessutom med fördel användas av praktiker som vill få en strukturerad redogörelse för den allmänna avtalsrätten och dess närliggande frågor. Bokens innehåll ger en bred inblick i den allmänna avtalsrätten, med praktiska exempel och hänvisningar till rättsfall. Läsaren får god kännedom om hur avtal kommer till stånd i olika sammanhang dels enligt avtalslagens regler, dels enligt regler utanför avtalslagens område. Avtal sluts för olika ändamål, och detta har beaktats av författaren. Boken innehåller dessutom redogörelser för olika mellanmanssituationer samt avtals och andra rättshandlingars ogiltighet. Andra delar som läsaren får bekanta sig med är principer och metoder för avtalstolkning och ett avsnitt om avtalsbrott.

  • 249632.
    Zetterström, Stefan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Övningsbok Civilrätt2014 (ed. 4)Book (Other academic)
  • 249633.
    Zetterström, Stefan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Övningsboken till Offentlig rätt2012 (ed. 1)Book (Other academic)
  • 249634.
    Zetterström, Stefan
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Lind, Anna-Sara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Offentlig rätt2016 (ed. 2)Book (Other academic)
  • 249635.
    Zetterstéen, Karl Vilhelm
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Die arabischen, persischen und türkischen Handschriften der Universitätsbibliothek zu Uppsala verzeichnet und beschrieben: Fortsetzung des von C.J. Tornberg im Jahre 1849 herausgegebenen Katalogs nebst einem Anhang, hebräische, syrische und samaritanische Handschriften enthaltend. 11930Book (Other academic)
  • 249636.
    Zetterstéen, Karl Vilhelm
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Die arabischen, persischen und türkischen Handschriften der Universitätsbibliothek zu Uppsala verzeichnet und beschrieben: Fortsetzung des von C.J. Tornberg im Jahre 1849 herausgegebenen Katalogs nebst einem Anhang, hebräische, syrische und samaritanische Handschriften enthaltend. 21935Book (Other academic)
  • 249637.
    Zettinig, Peter
    et al.
    Turku School of Economics, Finland.
    Mockaitis, Audra I.
    Victoria University of Wellington, New Zealand.
    Zander, Lena
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Students as Global Virtual Team Leaders: A Model for Enquiry-Based Experiential Learning2014In: The Palgrave Handbook of Experiential Learning in International Business / [ed] Vas Taras & Maria Alejandra Gonzalez-Perez, Basingstoke: Palgrave Macmillan, 2014, p. 33-50Chapter in book (Refereed)
  • 249638.
    Zewenghiel, Luwam
    et al.
    Orebro Univ, Inst Med Sci, Campus USO, S-70182 Orebro, Sweden.
    Lindman, Henrik
    Akad Univ Hosp, Dept Oncol, Uppsala, Sweden.
    Valachis, Antonis
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Malarsjukhuset, Dept Oncol, Eskilstuna, Sweden.
    Impact of body mass index on the efficacy of endocrine therapy in patients with metastatic breast cancer - A retrospective two-center cohort study2018In: Breast, ISSN 0960-9776, E-ISSN 1532-3080, Vol. 40, p. 136-140Article in journal (Refereed)
    Abstract [en]

    Bakground: The aim of this study was to investigate the impact of body mass index (BMI) on the efficacy of endocrine therapy in postmenopausal women with metastatic hormone receptor breast cancer (HR+BC) as well as to identify if the potential difference in efficacy was associated with Fulvestrant only or both aromatase inhibitors (AIs) and Fulvestrant. Methods: A consecutive cohort of postmenopausal women with HR+metastatic breast cancer that have received endocrine therapy including Fulvestrant as a metastatic treatment strategy at the Departments of Oncology in Eskilstuna and Uppsala, Sweden, between 2008 and 2016 were identified. The primary outcome of the study was time to disease progression (TTP) during the treatment with Fulvestrant in overweight and obese women compared to patient with normal BMI. Results: In total, 173 patients were enrolled in the study cohort, amongst these, 141 patients received both Fulvestrant and Als and 32 received only Fulvestrant. No statistical significant association was observed between the three BMI categories and TTP, during Fulvestrant treatment (p = 0.136). The rates of objective response and clinical benefit due to Fulvestrant were similar among patients with normal weight, overweight and obesity, respectively. Conclusions: No difference in treatment efficacy was seen between normal, overweight and obese women with metastatic HR+BC, when treated with Fulvestrant. Until further research with prospective studies is available, there is no evidence to support any modification in how Fulvestrant treatment is used in patients with metastatic breast cancer in regard to BMI.

  • 249639.
    Zewinger, Stephen
    et al.
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany..
    Kleber, Marcus E.
    Friedrich Schiller Univ, Inst Nutr, Jena, Germany..
    Tragante, Vinicius
    McCubrey, Raymond O.
    Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA..
    Schmidt, Amand F.
    Direk, Kenan
    Laufs, Ulrich
    Saarland Univ Hosp, Dept Internal Med 3, Homburg, Germany..
    Werner, Christian
    Saarland Univ Hosp, Dept Internal Med 3, Homburg, Germany..
    Koenig, Wolfgang
    Univ Ulm Med Ctr, Dept Internal Med Cardiol 2, Ulm, Germany.;Tech Univ Munich, Deutsch Herzzentrum M nchen, Munich, Germany.;Partner site Munich Heart Alliance, German Ctr Cardiovasc Res DZHK, Munich, Germany..
    Rothenbacher, Dietrich
    German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany.;Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany.;German Ctr Cardiovasc Res DZHK eV, Kiel, Germany..
    Mons, Ute
    German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany..
    Breitling, Lutz P.
    German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany.;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany..
    Brenner, Herrmann
    Heidelberg Univ, Dept Med, Network Ageing Res, Mannheim, Germany.;German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany..
    Jennings, Richard T.
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany..
    Petrakis, Ioannis
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany..
    Triem, Sarah
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany..
    Klug, Mira
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany..
    Filips, Alexandra
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.;UCL, Inst Cardiovasc Sci Facultyof Populat Hlth Sc, London, England..
    Blankenberg, Stefan
    Waldeyer, Christoph
    Sinning, Christoph
    Schnabel, Renate B.
    Lackner, Karl J.
    Univ Med Ctr Mainz, Inst Clin Chem & Lab Med, Mainz, Germany..
    Vlachopoulou, Efthymia
    Univ Helsinki, Haartman Inst, Transplantat Lab, Helsinki, Finland..
    Nygard, Ottar
    Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Heart Dis, Bergen, Norway..
    Svingen, Gard Frodahl Tveitevag
    Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Heart Dis, Bergen, Norway..
    Pedersen, Eva Ringdal
    Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Heart Dis, Bergen, Norway..
    Tell, Grethe S.
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland..
    Sinisalo, Juha
    Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria..
    Nieminen, Markku S.
    Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore..
    Laaksonen, Reijo
    Tampere Univ, Sch Med, Tampere, Finland.;Tampere Univ Hosp, Finnish Clin Biobank Tampere, Tampere, Finland..
    Trompet, Stella
    German Ctr Cardiovasc Res DZHK eV, Kiel, Germany.;Leiden Univ Med Ctr, Dept Geriat & Gerontol, Leiden, Netherlands.;Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands..
    Smit, Roelof A. J.
    Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.;Leiden Univ Med Ctr, Dept Geriat & Gerontol, Leiden, Netherlands.;Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands..
    Sattar, Naveed
    Heidelberg Univ, Dept Med, Mannheim, Germany.;Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland..
    Jukema, J. Wouter
    Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Inst Netherlands, Interunivers Cardiol, Utrecht, Netherlands..
    Groesdonk, Heinrich V.
    Saarland Univ Hosp, Dept Anesthesiol Intens Care Med & Pain Med, Homburg, Germany.;German Ctr Cardiovasc Res DZHK eV, Kiel, Germany.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand..
    Delgado, Graciela
    Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland.;Inst Netherlands, Interunivers Cardiol, Utrecht, Netherlands..
    Stojakovic, Tatjana
    Heidelberg Univ, Dept Med, Mannheim, Germany.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland..
    Pilbrow, Anna P.
    Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands..
    Cameron, Vicky A.
    Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland.;Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand..
    Richards, A. Mark
    Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand.;Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore..
    Doughty, Robert N.
    Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland.;Univ Auckland, Hlth Res Grp, Auckland, New Zealand..
    Gong, Yan
    Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland..
    Cooper-DeHoff, Rhonda
    Johnson, Julie
    German Ctr Cardiovasc Res DZHK eV, Kiel, Germany.;Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand..
    Scholz, Markus
    Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.;Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.;Univ Leipzig, D-RES CTR C Leipzig, Germany..
    Beutner, Frank
    Univ Leipzig, Leipzig, Germany..
    Thiery, Joachim
    Univ Hosp, Leipzig, Germany..
    Smith, J. Gustav
    Lund Univ, Dept Cardiol, Clin Sci, Lund, Sweden.;Skane Univ Hoswpital, Lund, Sweden..
    Vilmundarson, Ragnar O.
    Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada..
    McPherson, Ruth
    Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada..
    Stewart, Alexandre F. R.
    Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.;Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Washington Univ, Sch Med, St Louis, MO USA..
    Cresci, Sharon
    Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Washington Univ, Sch Med, Dept Med, St Louis, MO USA.;Washington Univ, Sch Med, Dept Genet, St Louis, MO USA..
    Lenzini, Petra A.
    Inst Med Informat, Stat & Epidemiol, Leipzig, Germany.;Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Washington Univ, Sch Med, Stat Genom Div, Dept Genet, St Louis, MO USA..
    Spertus, John A.
    Inst Med Informat, Stat & Epidemiol, Leipzig, Germany.;St Lukes Mid Amer Heart Inst, Kansas City, MO USA.;Univ Missouri, Dept Biomed Hlth Informat, Kansas City, MO USA..
    Olivieri, Oliviero
    Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Univ Verona, Dept Med, Verona, Italy..
    Girelli, Domenico
    Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Univ Verona, Dept Med, Verona, Italy..
    Martinelli, Nicola I.
    Univ Verona, Dept Med, Verona, Italy..
    Leiherer, Andreas
    Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Inst Med Informat, Stat & Epidemiol, Leipzig, Germany.;Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria.;Principal Liechtenstein, Private Univ, Triesen, Liechtenstein..
    Saely, Christoph H.
    Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria.;Principal Liechtenstein, Private Univ, Triesen, Liechtenstein..
    Drexel, Heinz
    Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria.;Principal Liechtenstein, Private Univ, Triesen, Liechtenstein.;Acad Teaching Hosp Feldkirch, Dept Med & Cardiol, Feldkirch, Austria.;Drexel Univ, Coll Med, Philadelphia, PA USA..
    Muendlein, Axel
    Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria..
    Braund, Peter S.
    Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Univ Leicester, Glenfield Hosp, Dept Cardiovascular Sci, BHF Cardiovascular Res Ctr, Leicester, Leics, England..
    Nelson, Christopher P.
    Univ Leicester, Glenfield Hosp, Dept Cardiovascular Sci, BHF Cardiovascular Res Ctr, Leicester, Leics, England..
    Samani, Nilesh J.
    Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Leicester NIHR Biomed Res Unit Cardiovasc Dis, Glenfield Hosp, Leicester, Leics, England.;Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.;Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden..
    Kofink, Daniel
    Hoefer, Imo E.
    Pasterkamp, Gerard
    Quyyumi, Arshed A.
    Emory Univ, Emory Clin Cardiovascular Res Inst, Atlanta, GA USA.;Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.;Uppsala Univ, Dept Med Sci, Clin Chem, Uppsala, Sweden..
    Ko, Yi-An
    Hartiala, Jaana A.
    Univ Southern Calif, Los Angeles, CA USA.;Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden..
    Allayee, Hooman
    Tang, W. H. Wilson
    Hazen, Stanley L.
    Heidelberg Univ, Dept Med, Mannheim, Germany..
    Eriksson, Niclas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Held, Claes
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Hagström, Emil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Åkerblom, Axel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Siegbahn, A
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Karp, Igor
    Univ Western Ontario, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, England..
    Labos, Christopher
    Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;McGill Univ, Dept Med, Montreal, PQ, Canada..
    Pilote, Louise
    McGill Univ, Dept Med, Montreal, PQ, Canada..
    Engert, James C.
    McGill Univ, Dept Med, Montreal, PQ, Canada..
    Brophy, James M.
    McGill Univ, Dept Med, Montreal, PQ, Canada.;Univ Laval, Dept Med, Laval, PQ, Canada..
    Thanassoulis, George
    McGill Univ, Dept Med, Montreal, PQ, Canada..
    Bogaty, Peter
    McGill Univ, Dept Med, Montreal, PQ, Canada..
    Szczeklik, Wojciech
    Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;Jagielonian Univ, Coll Med, Krakow, Poland..
    Kaczor, Marcin
    Jagielonian Univ, Coll Med, Krakow, Poland..
    Sanak, Marek
    Jagielonian Univ, Coll Med, Krakow, Poland..
    Virani, Salim S.
    Baylor Coll Med, Cardiol Sect, Michael DeBakey Vet Affairs Med Ctr, Houston, TX USA..
    Ballantyne, Christie M.
    Baylor Coll Med, Sect Cardiovasc, Dept Med, Houston, TX USA..
    Lee, Vei-Vei
    Texas Heart Inst, Dept Biostat 7, Houston, TX USA..
    Boerwinkle, Eric
    Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;Univ Texas Houston, Sch Publ Hlth, Houston, TX USA..
    Holmes, Michael V.
    Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England.;Univ Oxford, Natl Inst Hlth Res Oxford Biomed Res Ctr, Oxford, England..
    Horne, Benjamin D.
    Univ Oxford, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Epidemiol Studies Unit CTSU, Nuffield Dept Populat Hlth, Oxford, England..
    Hingorani, Aroon
    Asselbergs, Folkert W.
    Durrer Ctr Cardiogenet Res, ICIN, Utrecht, Netherlands..
    Patel, Riyaz S.
    Kraemer, Bernhard K.
    Scharnagl, Hubert
    Fliser, Danilo
    Maerz, Winfried
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.;Synlab Acad, Synlab Holding, Mannheim, Germany..
    Speer, Thimoteus
    Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study2017In: The Lancet Diabetes and Endocrinology, ISSN 2213-8587, E-ISSN 2213-8595, Vol. 5, no 7, p. 534-543Article in journal (Refereed)
    Abstract [en]

    Background: Lipoprotein(a) concentrations in plasma are associated with cardiovascular risk in the general population. Whether lipoprotein(a) concentrations or LPA genetic variants predict long-term mortality in patients with established coronary heart disease remains less clear.

    Methods: We obtained data from 3313 patients with established coronary heart disease in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. We tested associations of tertiles of lipoprotein(a) concentration in plasma and two LPA single-nucleotide polymorphisms ([SNPs] rs10455872 and rs3798220) with all-cause mortality and cardiovascular mortality by Cox regression analysis and with severity of disease by generalised linear modelling, with and without adjustment for age, sex, diabetes diagnosis, systolic blood pressure, BMI, smoking status, estimated glomerular filtration rate, LDL-cholesterol concentration, and use of lipid-lowering therapy. Results for plasma lipoprotein(a) concentrations were validated in five independent studies involving 10 195 patients with established coronary heart disease. Results for genetic associations were replicated through large-scale collaborative analysis in the GENIUS-CHD consortium, comprising 106 353 patients with established coronary heart disease and 19 332 deaths in 22 studies or cohorts.

    Findings: The median follow-up was 9.9 years. Increased severity of coronary heart disease was associated with lipoprotein(a) concentrations in plasma in the highest tertile (adjusted hazard radio [HR] 1.44, 95% CI 1.14-1.83) and the presence of either LPA SNP (1.88, 1.40-2.53). No associations were found in LURIC with all-cause mortality (highest tertile of lipoprotein(a) concentration in plasma 0.95, 0.81-1.11 and either LPA SNP 1.10, 0.92-1.31) or cardiovascular mortality (0.99, 0.81-1.2 and 1.13, 0.90-1.40, respectively) or in the validation studies.

    Interpretation: In patients with prevalent coronary heart disease, lipoprotein(a) concentrations and genetic variants showed no associations with mortality. We conclude that these variables are not useful risk factors to measure to predict progression to death after coronary heart disease is established.

  • 249640.
    Zeydanlioǧlu, Welat
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, The Hugo Valentin Centre.
    Turkey's kurdish language policy2012In: International Journal of the Sociology of Language, ISSN 0165-2516, E-ISSN 1613-3668, no 217, p. 99-125Article in journal (Refereed)
    Abstract [en]

    This article examines the Turkish state's assimilationist policy towards the Kurds and the Kurdish language in Turkey. It studies how the Turkish nationalist elites, the Kemalists, have throughout the 20th century systematically suppressed the Kurdish language as part of their aim to construct a homogenous nation- state of Turkish speakers. It shows that this linguicidal policy was strongly informed by the traumatic collapse of the Ottoman Empire and the consequent Kemalist emphasis on complete ethno-linguistic homogeneity as criteria for being "Turkish", "Western" and "civilised". The article discusses the various " Turkification" strategies of the authorities, such as banning the Kurdish language, the denial of the existence of the Kurds, changing the names of towns and villages, the forced re-settlement of Kurds and the assimilation of Kurdish children. It critically analyses the recent developments in Turkey's Kurdish language policy and the reform efforts of the current government as part of the country's EU candidacy. The article reflects however, that whilst looking good on paper, these reforms have had little impact in reality and Kurdish speakers in Turkey are still systematically denied their basic human and linguistic rights.

  • 249641. Zeymer, Uwe
    et al.
    James, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Berkenboom, Guy
    Mohacsi, Attila
    Iñiguez, Andres
    Coufal, Zdenek
    Sartral, Magali
    Paget, Marie-Ange
    Norrbacka, Kirsi
    Ferrieres, Jean
    Bakhai, Ameet
    Differences in the use of guideline-recommended therapies among 14 European countries in patients with acute coronary syndromes undergoing PCI2013In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 20, no 2, p. 218-228Article in journal (Refereed)
    Abstract [en]

    Aims:

    Despite common European Society of Cardiology recommendations, adherence to guideline therapy varies, both temporally and geographically. We sought to examine current differences in the use of guideline-recommended therapies among 14 European countries in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).

    Methods and Results:

    Data were obtained from the Antiplatelet Therapy Observational Registry (APTOR), a non-interventional, prospective observational cohort study enrolling patients with ACS undergoing PCI. Medication data were captured through 1 year. The large majority of patients in the APTOR registry received statins at hospital discharge (89%) and remained on statins at 1 year (87%), a finding that was consistent across countries. Likewise, beta-blocker use was similar at discharge and 1 year (83 and 81%, respectively). There was large disparity in aspirin loading dose between countries, but the discharge maintenance dose was more consistent, with most receiving ≤100 mg (87%). While 95% of patients were discharged on dual antiplatelet therapy, 71% remained on both treatments by 1 year, with wide variation by country in 1-year use.

    Conclusions:

    These data from the APTOR study provide key information on current European ACS patient care management from hospitalization through 1 year. Even with European Society of Cardiology (ESC) guidelines, variations in practice patterns exist among ACS patients treated with PCI between the 14 European countries studied, including the use of proven therapies, as well as appropriate duration and dosing of antiplatelet regimens. Efforts are needed to further explain why such variation exists and to continue to improve adherence to ESC guidelines to improve patient care.

  • 249642. Zezina, L
    et al.
    Larsson, E
    Fellstrom, Bengt
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.
    Angiotensin II receptor type I blocker Candesartan cilexetil reduces the development of chronic rejection in rat aortic grafts2001In: Transplant Immunology, p. 245-51Article in journal (Other (popular scientific, debate etc.))
  • 249643. Zezina, L
    et al.
    Larsson, E
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
    Fellström, B
    Candesartan cilexetil reduces graft arteriosclerosis in aortic transplantation model in rat.2001In: Transpl Immunol, ISSN 0966-3274, Vol. 8, no 4, p. 245-51Article in journal (Refereed)
  • 249644. Zezina, L
    et al.
    Larsson, E
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
    Fellström, B
    Department of Medical Sciences.
    Canderstan cilexitl reduces graft arteriosclerosis inaortic transplantation model in rat2001In: Transplant Immunol, Vol. 8(4), p. 245-Article in journal (Refereed)
  • 249645. Zezina, Lelija
    et al.
    Dimeny, Emoke
    Vessby, Bengt
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Fellstrom, Bengt
    Department of Medical Sciences.
    Serum levels of antibodies against oxidised LDL in kidney graft recipients.2002In: Am J Nephrol, ISSN 0250-8095, Vol. 22, no 5-6, p. 539-47Article in journal (Other scientific)
  • 249646.
    Zezina, Lilian
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.
    Vessby, Bengt
    Department of Public Health and Caring Sciences.
    Larsson, Erik
    Department of Genetics and Pathology.
    Backman, Ulla
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.
    Fellstrom, Bengt
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.
    Carvedilol treatment of kidney graft recipients with chronic rejection.1999In: Clin Transplant, Vol. 13, p. 484-Article in journal (Refereed)
  • 249647.
    Zezina, Lilija
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Mechanisms and treatment options of chronic graft dysfunction: Experimental and clinical studies2001Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Chronic graft dysfunction (CGD) is an important post-transplant complication. CGD can be considered as an impaired repair process, which ultimately leads to the loss of graft function.To study non-immunological factors contributing to the development of CGD in kidney grafts we used in vitro and in vivo models, and clinical studies.

    We studied the actions of hyperlipidemia in vitro. LDL induced increased expression of TGF-β1 and TGF-β receptors type I and type II. Smad2 phosphorylation could be induced by conditioned medium from mesangial cells incubated with LDL.

    The effects of Fluvastatin and AT1 receptor blocker Candesartan cilexetil on aortic graft arteriosclerosis in the rat were evaluated. Fluvastatin neither alone nor in combination with Cyclosporine A affected allograft remodelling, but reduced neointima formation in isografts. Candesartan cilexetil treatment reduced graft arteriosclerosis. The effect is explained by the reduction of TGF-β1 expression.

    We investigated the effects of Carvedilol in patients with CGD. Carvedilol failed to alter the CGD progression despite the efficient control of blood pressure, and a beneficial effect on lipid pattern and oxidation. Close control of CyA blood levels is recommended due to interaction between CyA and Carvedilol.

    Measurement of Ab-oxLDL in kidney graft recipients demonstrated that these patients had lower Ab-oxLDL levels as compared with the control group. Decreased Ab-oxLDL levels were associated with graft loss due to acute rejection and with ischemic heart disease.

    In this thesis we have addressed several important complex issues, which are interconnected: (1) development of chronic graft dysfunction (2) lipoproteins and their role in inducing pathological conditions like atherosclerosis and graft damage, (3) oxidation, (4) TGF-β and its' role in different pathological conditions, including renal and vascular damage.

  • 249648.
    Zečić, Aleksandra
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
    Noonin, Chadanat
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
    Whole-mount in situ hybridization: minimizing the folding problem of thin-sheet tissue-like crayfish haematopoietic tissue2018In: Crustaceana, ISSN 0011-216X, E-ISSN 1568-5403, Vol. 91, no 1, p. 1-15Article in journal (Refereed)
    Abstract [en]

    Crayfish haematopoietic tissue (HPT) has a thin-sheet-like structure with a thickness of 100-160 μm and a width of approximately 1-2 cm. This structure makes HPT extremely easy to fold after removal from the animal. Therefore, it is difficult to handle the tissue without folding when processing for sectioning and histological study. The degree of tissue folding reflects the size of the tissue sections obtained, how complicated it is to interpret the location of each tissue section, and the accuracy of the interpretation of the location of a specific transcript. To facilitate the interpretation of a specific transcript location in the HPT, we optimized a whole-mount in situ hybridization technique to minimize tissue folding. This optimized protocol effectively reduced the tissue folding. Therefore, the location of a specific transcript in the HPT was easily and accurately defined. This protocol will be useful for whole-mount staining of other tissues with similar structure.

  • 249649.
    Zguns, Pjotrs A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. KTH Royal Inst Technol, Dept Mat Sci & Engn, S-10044 Stockholm, Sweden..
    Wessel, Michael
    Univ Duisburg Essen, Fac Chem, D-45141 Essen, Germany..
    Skorodumova, Natalia V.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. KTH Royal Inst Technol, Dept Mat Sci & Engn, S-10044 Stockholm, Sweden..
    Cu adatom charging on Mo supported ScN, MgO and NaF2015In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 5, no 114, p. 94436-94445Article in journal (Refereed)
    Abstract [en]

    Molybdenum supported thin films of ScN, MgO and NaF with a Cu adatom have been studied in the framework of density functional theory. We have observed a charge transfer from the metal/film interface to the Cu atom and investigated its relation to surface and interface deformations. We find that a weak interaction between the metal and the film is a promising prerequisite for adatom charging. The detailed study of Cu/NaF/Mo and NaF/Mo indicates that the distortion of the NaF film caused by the Cu adsorption has essentially anharmonic character, as it is coupled to a strong charge redistribution in the system.

  • 249650.
    Zha, Yinghua
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Assembly of Gut Microbial Communities in Freshwater Fish and Their Roles in Fish Condition2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Animal hosts provide associated microorganisms with suitable ecological niches in their intestines. Microbes help their hosts to digest food, protect against pathogens, and influence the host’s metabolisms. Compositional variation of gut microbial communities is common among hosts, and may affect the health status of hosts. Diet and genetic factors are well known to influence the assembly of gut microbial communities. This thesis focuses on disentangling the contributions of factors including host genetics (sex), diet, environment, and other ecological processes to the assembly of gut microbial communities in freshwater fish. The association between gut microbial communities and fish condition is also evaluated in this thesis.

    Applying metacommunity theory, we found environmental factors including fish habitat, fish species, their diet, dispersal factors including microbes from fish diet, and ecological drift contributed to the assembly of fish gut microbial communities. The proportion of their contribution varied between fish species, where ecological drift explained more in perch than in roach.

    Under natural conditions fish populations face the risk of predation, which can induce competition and impose predation stress within prey individuals. This can therefore lead to changes in their diet qualities and quantities. In this thesis, it was shown that fish diet in terms of qualities and quantities significantly influenced the overall gut microbial composition, and this influence was dependent on fish sex, a host genetic factor. Predation stress was also suggested to significantly decrease the species richness. Furthermore, when fish were experiencing a diet shift, we showed that different bacterial phyla from novel food had different colonization success in the intestine, and this colonization success was positively influenced by predation stress. Fish condition was suggested in this thesis to be affected by gut microbial composition, especially by the contributions of the bacterial phyla Tenericutes and Actinobacteria.

    List of papers
    1. Contributions of environment and ecological processes to gut microbial communities in freshwater fish
    Open this publication in new window or tab >>Contributions of environment and ecological processes to gut microbial communities in freshwater fish
    (English)Manuscript (preprint) (Other academic)
    National Category
    Ecology Microbiology
    Identifiers
    urn:nbn:se:uu:diva-314231 (URN)
    Available from: 2017-01-31 Created: 2017-01-31 Last updated: 2017-02-01
    2. Stress responses in intestinal microbiota and host condition depend on gender and diet in a vertebrate
    Open this publication in new window or tab >>Stress responses in intestinal microbiota and host condition depend on gender and diet in a vertebrate
    (English)Manuscript (preprint) (Other academic)
    National Category
    Ecology Microbiology
    Identifiers
    urn:nbn:se:uu:diva-314232 (URN)
    Available from: 2017-01-31 Created: 2017-01-31 Last updated: 2017-01-31
    3. Effects of food ration and predation stress on perch gut microbial communities
    Open this publication in new window or tab >>Effects of food ration and predation stress on perch gut microbial communities
    (English)Manuscript (preprint) (Other academic)
    National Category
    Ecology Microbiology
    Identifiers
    urn:nbn:se:uu:diva-314233 (URN)
    Available from: 2017-01-31 Created: 2017-01-31 Last updated: 2017-01-31
    4. Colonization and extinction probabilities in fish gut microbial communities under diet switch and predation stress
    Open this publication in new window or tab >>Colonization and extinction probabilities in fish gut microbial communities under diet switch and predation stress
    (English)Manuscript (preprint) (Other academic)
    National Category
    Ecology Microbiology
    Identifiers
    urn:nbn:se:uu:diva-314234 (URN)
    Available from: 2017-01-31 Created: 2017-01-31 Last updated: 2017-01-31
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