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  • 251. Frank, Adrian
    et al.
    Danielsson, Rolf
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Analytisk kemi.
    Selenius, Olle
    Comparison of two monitoring systems for Cu and Mo in the Swedish environment2004In: Science of the Total Environment, no 330, p. 131-143Article in journal (Refereed)
    Abstract [en]

    Bio-geochemical samples (BGS) are roots of certain aquatic plants and mosses suitable for monitoring elements dissolved in stream water. The moose, a wild ruminant living in most parts of Sweden, represents higher trophic level and another manifestation of bioavailability. By analyzing BGS (n=33 600) and moose liver (n=2400), a systematic survey has been performedin the terrestrial environment of Sweden. Cu and Mo are essential elements for life, and their presence is especially important for the Cu-dependent processes in ruminants. The availability of Cu and Mo as monitored in BGS and moose was visualized in the form of maps and subjected to further statistical analysis. The medians, with lower and upper quartiles indicated as intervals, for the country as a whole were: moose liver, Cu=34 (20-59), Mo=0.82 (0.58-1.06) mg kg -1 wet weight; BGS, Cu=50 (35-77), Mo=9.0 (5.3-18.0) mg kg -1 dry weight. The ranges of medians for the 22 Swedish counties were: moose liver, Cu=(20-62), Mo=(0.54-1.18) mg kg -1 wet weight; BGS, Cu=(28-115), Mo=(5-47) mg kg -1 dry weight. The relationships between the counties and the connections between the monitoring variables were elucidated by principal component analysis (PCA). It was demonstrated that two monitoring systems could give divergent results. An unexpectedly strong negative correlation was found between the county medians for Cu in BGS and moose liver. A possible explanation, based on the interaction between Cu and Mo in moose, could not be verified.

  • 252. Frank, Adrian
    et al.
    McPartlin, Joe
    Danielsson, Rolf
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Analytisk kemi.
    Nova Scotia moose mystery - a moose sickness related to cobalt- and vitamin B12 deficiency2004In: The Science of the Total Environment, no 318, p. 89-100Article in journal (Refereed)
    Abstract [en]

    A wasting, debilitating disease with uncertain aetiology, affecting moose (Alces alces americana) in Eastern North America has been reported repeatedly ever since the 1910s. Despite the intensive studies during 1930-1960s the cause of the sickness could not be established. In the 1960s a parasitic nematode (Parelaphostrongylus tenuis) was reported as constituting a probable explanation for the sickness, although several clinical and pathological signs remained unexplained. In Sweden, a moose disease with similar signs, has been shown to be caused by molybdenosis resulting from a nutritional imbalance. The findings of this investigation were applied in Nova Scotia to determine trace element concentrations in tissues from indigenous moose. Co deficiency was found in about half of the cases and the investigation was complemented by determining the vitamin B12 level, which proved nutritional Co/vitamin B12 deficiency, further verified by an increased MMA (methylmalonic acid) level in plasma. Deficiencies were found mainly in the Tobeatic and Cape Breton Highland regions. No indications of molybdenosis or other trace element disturbances were found in Nova Scotia. Otherwise, extremely high Cd levels (148 mg Cd/kg kidney wet wt., maximum) were found, though probably not contributing to the moose sickness. The Cd burden of moose on mainland Nova Scotia was more than 50% higher than that of moose in Huntville and Alonquin (Ontario, Canada) and five- to six-fold is higher than the highest Cd levels found in Sweden. To counteract the bio-geochemical effects of Co deficiency in the moose environment, provision of Co-containing salt licks is suggested.

  • 253.
    Fridstrom, A
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Nyholm, L
    Netscher, T
    Walther, W
    Lundell, N
    Markides, KE
    Neutral cyclodextrins as chiral agents for enantiomeric separations of chromanes in capillary electrophoresis1997In: CHROMATOGRAPHIA, ISSN 0009-5893, Vol. 44, no 5-6, p. 313-319Article in journal (Refereed)
    Abstract [en]

    Six different cyclodextrins with varying cavity size and rim substitution were used as chiral agents for the enantiomeric separation of eight chromane compounds or analogues using capillary electrophoresis. It is shown that the cyclodextrin type and conc

  • 254.
    Frisell, H
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Engman, L
    Molecular modelling of some para-substituted aryl methyl telluride and diaryl telluride antioxidants2000In: JOURNAL OF MOLECULAR STRUCTURE, ISSN 0022-2860, Vol. 526, p. 103-114Article in journal (Refereed)
    Abstract [en]

    Quantum mechanical calculations using the 3-21G(d) basis-set were performed on some p-substituted diaryl tellurides and aryl methyl tellurides, and the corresponding cationic radicals of these compounds. Calculated relative radical stabilization energies

  • 255. Fritschij, FC
    et al.
    Brom, HB
    Berger, R
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Oorganisk kemi.
    NMR and susceptibility characterization of two oxocuprates with antiferromagnetic Cu-chains: LiCuO2 and LiCu2O21998In: SOLID STATE COMMUNICATIONS, ISSN 0038-1098, Vol. 107, no 12, p. 719-723Article in journal (Refereed)
    Abstract [en]

    The CuO2 compounds LiCuO2 and LiCu2O2 both contain CuO4 squares knit together in linear chains. These chains are all equivalent in LiCuO2 and grouped in pairs in LiCu2O2. From susceptibility measurements the spin interaction in both compounds is seen to be dominated by Heisenberg antiferromagnetic exchange

  • 256.
    Frykholm P., Andersson J L., Valtysson J., Silander H C., Hillered L., Persson L., Olsson Y., Yu W R., Westerberg G., Watanabe Y., Långström B., Enblad P.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    A metacolic threshold of irreversible ischemia demonstrated by PET in a middle cerebral artery occlusion-reperfusion primate model2000Article in journal (Other scientific)
  • 257.
    Frykholm P., Hillered L., Långström B., Watanabe Y., Bergström M.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusionreperfusion primate model2001In: Journal of Neurology, Neurosurgery And Psychiatry, no 2, p. 455-61Article in journal (Refereed)
  • 258. Fryxelius, Jacob
    et al.
    Eilers, Gerriet
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Feyziyev, Yashar
    Magnuson, Ann
    Sun, Licheng
    Lomoth, Reiner
    Synthesis and redox properties of a [meso-tris(4-nitrophenyl) corrolato]Mn(III) complex.2005In: Journal of Porphyrins and Phthalocyanines, ISSN 1088-4246, E-ISSN 1099-1409, no 9(6), p. 379-386Article in journal (Refereed)
  • 259.
    Färnert Lindber, A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Gil, J
    Sweberg, A
    Bergqvist, G
    Thapar, Y
    Lindegårdh, M M
    Berezcky, N
    Björkman, S
    Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case reports2003In: BMJ, no 326, p. 628-629Article in journal (Refereed)
  • 260.
    Gadomska, J
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Donten, M
    Stojek, Z
    Nyholm, L
    Mass transport-controlled steady-state currents for methanol in a flow injection system1996In: ANALYST, ISSN 0003-2654, Vol. 121, no 12, p. 1869-1871Article in journal (Refereed)
    Abstract [en]

    It is known that undiluted methanol can give mass transport-controlled steady-state oxidation currents at Pt microelectrodes. In the present study, the steady-state currents were examined under flow injection conditions. It was found that the methanol ox

  • 261. Gassner, Helmut
    et al.
    Probst, Michael
    Lauenstein, Albert
    Hermansson, Kersti
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Representation of intermolecular potential functions by neural networks1998In: Journal of Physical Chemistry A, ISSN 1089-5639, E-ISSN 1520-5215, Vol. 102, no 24, p. 4596-4605Article in journal (Refereed)
    Abstract [en]

    We have investigated how a neural network representation of intermolecular potential functions can be used to elevate some of the problems commonly encountered during fitting and application of analytical potential functions in computer simulations. For this purpose we applied feed-forward networks of various sizes to reproduce the three-body interaction energies in the system H(2)O-Al(3+)-H(2)O. In this highly polarizable system the three-body interaction terms are necessary for an accurate description of the system, and it proved difficult to fit an analytical function to them. Subsequently we performed Monte Carlo simulations on an Al(3+ )ion dissolved in water and compared the results obtained using the neural network type potential function with those using a conventional analytical potential. The performance and results of our calculations lead to the conclusion that, for suitable systems, the advantages of a neural network type representation of potential functions as a model-independent and "semiautomatic" potential function outweigh the disadvantages in computing speed and lack of interpretability.

  • 262.
    Gaul C., Arvidsson P., Bauer W., Gawley R., Seebach D.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Computational reactIR-, and NMR-spectroscopic investigations on the chiral formyl anion equivalent N-(a-lithiomethylthiomet hyl)-4-isopropyl-5,5-diphenyloxazolidin-2-one and related compounds2001In: Chemistry--A European Journal, no 7 (19), p. 4117-4125Article in journal (Refereed)
  • 263.
    Gayet, Arnaud
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Andersson, Pher
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Kinetic resolution of racemic epoxides using a chiral diamine catalyst2005In: Tetrahedron Letters, no 46, p. 4805-4807Article in journal (Refereed)
  • 264.
    Gayet, Arnaud
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Bertilsson, Sophie
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Andersson, Pher
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Novel Catalytic Kinetic Resolution of Racemic Epoxides to Allylic Alcohols2002In: Organic Letters, Vol. 4, no 22, p. 3777-3779Article in journal (Refereed)
  • 265.
    Gayet, Arnaud
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Organisk kemi.
    Bolea, Christine
    Andersson, Pher
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Organisk kemi.
    Development of new camphor based N,S chiral ligands and their application in transfer hydrogenation2004In: Organic & Biomolecular Chemistry, no 2, p. 1887-1893Article in journal (Refereed)
  • 266. Gedda, L
    et al.
    Ghaneolhosseini, H
    Nilsson, P
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Nyholm, K
    Pettersson, J
    Sjöberg, S
    Carlsson, J
    The influence of lipophilicity on binding of boronated DNA-intercalating compounds in human glioma speroids2000In: Anti-Cancer Drug Design, no 15, p. 277-286Article in journal (Refereed)
  • 267. GEJJI, SHRIDHAR P
    et al.
    HERMANSSON, KERSTI
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    LINDGREN, JAN
    ABINITIO VIBRATIONAL FREQUENCIES OF THE TRIFLATE ION, (CF3SO3)-1993In: J PHYS CHEM-US, ISSN 0022-3654, Vol. 97, no 15, p. 3712-3715Article in journal (Refereed)
    Abstract [en]

    The optimized geometry, harmonic vibrational frequencies and infrared intensities of the trifluoromethanesulfonate (triflate) ion, CF3SO3-, have been determined with ab initio self-consistent Hartree-Fock theory by using 3-21G* and 6-31G* Gaussian basis sets. Second-order Moller-Plesset perturbation calculations were also carried out with 6-31G* basis. A normal mode analysis shows that the vibrations assigned as symmetric and antisymmetric CF3 stretching involve other internal coordinates as well, viz., CF3 bending and CS stretching. The corresponding SO3 stretching modes, on the other hand, are almost entirely described with SO stretching coordinates. The assignments of the symmetric and antisymmetric SO3 and CF3 stretching vibrations from Moller-Plesset theory are seen to be different from those reported in the literature. Recent infrared spectroscopic experiments of the triflate ion coordinated to the zinc or lead ion in poly(ethylene oxide) complexes support the conclusions from second-order perturbation theory. The vibrational frequencies and infrared intensities show a strong dependence on basis set and electron correlation.

  • 268. GEJJI, SHRIDHAR P
    et al.
    HERMANSSON, KERSTI
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    LINDGREN, JAN
    AB-INITIO VIBRATIONAL FREQUENCIES OF THE TRIFLIC ACID MOLECULE1993In: J PHYS CHEM-US, ISSN 0022-3654, Vol. 97, no 27, p. 6986-6989Article in journal (Refereed)
    Abstract [en]

    The optimized geometry, harmonic vibrational frequencies, and infrared intensities of the trifluoromethanesulfonic (triflic) acid, CF3SO2OH, have been determined by ab initio self-consistent Hartree-Fock calculations and second-order Moller-Plesset perturbation theory with 6-31G** and lower basis sets. The optimized geometry of the triflic acid molecule is in good agreement with that reported from electron diffraction experiments. The overall symmetry for the molecule, however, is C1, and not C(s) as suggested from the experiments. The symmetric CF3 and SO2 stretching vibrational modes of the triflic acid are seen to be reversed compared to the assignment from the infrared spectra, reported earlier in the literature. The CF3 stretchings and the O=S=O bending normal modes include strong couplings of different internal coordinates. The vibrational frequencies and the infrared intensities are sensitive to the basis set choice as well as to electron correlation effects.

  • 269. GEJJI, SHRIDHAR P
    et al.
    HERMANSSON, KERSTI
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    LINDGREN, JAN
    STRUCTURE AND VIBRATIONAL FREQUENCIES OF THE MOLECULAR TRICHLOROMETHANESULFONIC ACID AND ITS ANION FROM AB-INITIO CALCULATIONS1994In: J PHYS CHEM-US, ISSN 0022-3654, Vol. 98, no 35, p. 8687-8692Article in journal (Refereed)
    Abstract [en]

    The equilibrium structure, vibrational frequencies, and the infrared intensities of the trichloromethanesulfonic acid molecule and its anion have been investigated using the ab initio self-consistent Hartree-Fock method and second-order Moller-Plesset perturbation theory with the 6-31G** and lower basis sets. A normal mode analysis shows that, unlike CCl3 stretchings, the SO3 stretching vibrations in the CCl3SO3- anion are pure normal modes comprised of S-O stretching coordinates only. The molecular point group for the trichloromethanesulfonic acid molecule is C-1 and not C-s. The vibrational frequencies and the infrared intensities are sensitive to the basis set choice as well as to the electron correlation effects.

  • 270. GEJJI, SHRIDHAR P
    et al.
    HERMANSSON, KERSTI
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    TEGENFELDT, JÖRGEN
    LINDGREN, JAN
    GEOMETRY AND VIBRATIONAL FREQUENCIES OF THE LITHIUM TRIFLATE ION-PAIR - AN AB-INITIO STUDY1993In: J PHYS CHEM-US, ISSN 0022-3654, Vol. 97, no 44, p. 11402-11407Article in journal (Refereed)
    Abstract [en]

    The optimized geometry, harmonic vibrational frequencies, and infrared absorption intensities of the lithium trifluoromethanesulfonate (triflate) ion pair, CF3SO3-Li have been investigated using the ab initio self-consistent Hartree-Fock and correlated second-order Moller-Plesset perturbation theory with the 6-31G* and lower basis sets. In the optimized structure the lithium cation is bound to two of the oxygens of the SO3 group forming a bidentate complex with C(s) symmetry. A local minimum with a monodentate structure was obtained in the HF/3-21G* calculations. The energy difference between the mono- and bidentate structures of the complex is predicted to be nearly 39 kJ mol-1 in this basis. A splitting of 230 and 158 cm-1 is obtained for the antisymmetric SO3 stretching for the bi- and monodentate coordination of the lithium cation with the free anion, respectively. The infrared spectrum of lithium triflate in poly(propylene oxide) shows a splitting of 43 cm-1. The strong interaction of the metal cation with the anion in the 1:1 complex thus overemphasizes the ''splitting behavior'' observed for lithium triflate dissolved in polymers. In the bidentate (MP2/6-31G*) complex the symmetric SO3 stretching shows a downshift of 38 cm-1, in contrast to an upshift of 47 cm-1 for the monodentate complex. The different signs of these frequency shifts have a purely geometric origin. The dependence of this frequency shift on the position of the Li+ ion is discussed.

  • 271.
    Ghaneolhosseini, Hadi
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Boron neutron capture therapy: Synthesis of boronated amines- and DNA intercalating agents for potential use in cancer therapy1998Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Boron Neutron Capture Therapy is a binary cancer treatment modality, involving the delivery of a suitable boron compound to tumour cells followed by irradiation of the tumour by thermal neutrons. Boronated agents can selectively be delivered to tumour cells either directly with tumour-specific boron compounds, or by use of targeting strategies. However, the efficacy of this method would increase if the boron agents are localised in the cell nucleus rather than in the cell cytoplasm when neutron irradiation takes place. With these considerations in mind, some boronated DNA intercalating/interacting agents such as phenantbridine- acridine spermidine and naphthalimide derivatives were synthesised.

    Amincalkyl-o-carboranes were synthesised in order to be used both for coupling to macromolecules and also for halogenation of their corresponding nido- derivatives. The amino groups were introduced using the Gabriel reagent N, N-ditenzyl iminodicarboxylate to provide 1-(aminomethyl) and 1-(2-aminoethyl)-o-carboranes.

    The first attempt to achieve the possibility to accumulate a higher concentration of boron atoms in the cell nucleus was to synthesise carboranyl phenanthridinium analogues by reacting a p- or o- carboranyl moiety with phenanthridine, a chromophore with a planar aromatic ring system as DNA intercalator.

    Boronated acridine-spermidine, boronated diacridine, and boronated dispermidine were obtained in orderto 1) increase water solubility to avoid the interaction of these agents with non-DNA sides of the cell, especially membranes; 2) enhance the feasibility of a higher DNA-binding constant and also decrease the DNA-drug dissociation rate.

    Finally, the synthesis of a boronated naphthalimide derivative was carried out by nucleophilic reaction of a primary aminoalkyl-p-carborane with naphthalic anhydride.

    Biological evaluations on DNA-binding, toxicity, and cellular binding with carboranyl phenanthridiniumanalogues, boronated acridine- and spermidine are described.

  • 272.
    Ghirmai, Senait
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Synthesis of Organic Compounds for Nuclide Therapy: Derivatives of Carboranes, 9-Aminoacridine and Anthracyclines2004Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis addresses the synthesis of organic compounds, some of them are derivatives of compounds with DNA binding properties, for potential use in targeted nuclide therapy. The compounds synthesized therefore also need to contain potent nuclides. Here the nuclides considered are the radionuclide 125I, and the stable isotope 10B, which becomes radioactive upon neutron activation. 125I is an Auger-electron emitter, which emits particles that can travel only about 1-2 µm through human tissue and hence has to be delivered to the cancer cell nucleus to cause DNA damage. Neutron activated 10B emits highly cell killing α-particles and 7Li3+ ions, the application of which in Boron Nuclide Capture Therapy (BNCT) has proven very promising.

    The thesis can be divided into three parts:

    i) A nido-carborate, 7-(3´-ammoniopropyl)-7,8-dicarba-nido-undecaborate(-1), has been synthesized and radioiodinated for use as a pendant group for attachment of 125I to tumor-seeking macromolecules. Radiolabeling was achieved in greater than 95% yield.

    ii) Both enantiomers of m-carboranylalanine, a carborane analogue of phenylalanine, have been prepared in high enantiomeric excess, and are of potential interest in BNCT. The synthesis involved amination of the N-acyl derivative formed from [3-(1,7-dicarba-closo-dodecarborane(12)-1-yl)-2-propanoic acid and Oppolzer’s camphor sultam.

    iii) Derivatives of the DNA intercalating compounds 9-aminoacridine, daunorubicin and doxorubicin have been synthesized and labeled with 125I. The 9-aminoacridines were synthesised with a variety of functional groups such as carboxyl, amino and hydroxyl. The anthracylines daunorubicin and doxorubicin are efficient chemotherapeutic agents; the synthesis routes of ester, amide and amine derivatives of these compounds are presented.

    The Chloramine T method was used for the radioiodinations, and the radioiodination precursors of both the acridine and the anthracycline derivatives, were made to contain either a trimethylstannyl group or a phenolic substituent. In the former case the trimethylstannyl group was replaced by 125I, and in the latter case, the compounds were radiolabeled directly at the o- position to the phenolic hydroxyl group. Both methods gave high radiolabeling yields.

    List of papers
    1. Synthesis and Radioiodination of 7-(3´-Ammoniopropyl)-7,8-dicarba-nido-undecaborate(-1), (ANC)
    Open this publication in new window or tab >>Synthesis and Radioiodination of 7-(3´-Ammoniopropyl)-7,8-dicarba-nido-undecaborate(-1), (ANC)
    Show others...
    2004 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 47, no 9, p. 557-569Article in journal (Refereed) Published
    Abstract [en]

    Derivatives of nido-carborate have potential use in tumour targeting as hydrophilic boron-rich compounds for boron neutron capture therapy (BNCT) and as pendant groups for attachment of radiohalogens to tumour-seeking molecules. For this purpose, functionalized derivatives of nido-carborates that can be conjugated to biomolecules should be synthesized and evaluated. In this study, racemic 1, 7-(3′-ammoniopropyl)-7,8-dicarba-nido-undecaborate(-1) (acronym ANC) was obtained by degradation of the corresponding aminopropyl-o-carborane, which was synthesized in three steps from 1-tert-butyldimethylsilyl-2-(3-bromopropyl)-o-carborane, with sodium hydroxide in absolute ethanol. The racemate 1 was radioiodinated (125I) using the Chloramine-T method. Radio-TLC results showed that radiolabelling with 125I was achieved in a yield greater than 95%.

    National Category
    Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-91769 (URN)10.1002/jlcr.840 (DOI)
    Available from: 2004-04-22 Created: 2004-04-22 Last updated: 2017-12-14Bibliographically approved
    2. Enantioselective Synthesis of m-Carboranylalanine a Boron-rich Analogue of Phenylalanine
    Open this publication in new window or tab >>Enantioselective Synthesis of m-Carboranylalanine a Boron-rich Analogue of Phenylalanine
    Article in journal (Refereed) Submitted
    Identifiers
    urn:nbn:se:uu:diva-91770 (URN)
    Available from: 2004-04-22 Created: 2004-04-22Bibliographically approved
    3. Synthesis and Radioiodination of Some 9-Aminoacridine Derivatives
    Open this publication in new window or tab >>Synthesis and Radioiodination of Some 9-Aminoacridine Derivatives
    Show others...
    2004 (English)In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, Vol. 17, p. 3719-3725Article in journal (Refereed) Published
    National Category
    Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-69939 (URN)10.1002/ejoc.200400296 (DOI)
    Available from: 2006-05-17 Created: 2006-05-17 Last updated: 2017-11-21Bibliographically approved
    4. Synthesis and radioiodination of some 9-aminoacridine derivatives for potential use in radionuclide therapy
    Open this publication in new window or tab >>Synthesis and radioiodination of some 9-aminoacridine derivatives for potential use in radionuclide therapy
    Show others...
    2005 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 48, no 12, p. 855-871Article in journal (Refereed) Published
    National Category
    Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-83610 (URN)10.1002/jlcr.960 (DOI)
    Available from: 2006-11-07 Created: 2006-11-07 Last updated: 2017-12-14Bibliographically approved
    5. Synthesis and radioiodination of some daunorubicin and doxorubicin derivatives
    Open this publication in new window or tab >>Synthesis and radioiodination of some daunorubicin and doxorubicin derivatives
    2005 (English)In: Carbohydrate Research, ISSN 0008-6215, E-ISSN 1873-426X, Vol. 340, no 1, p. 15-24Article in journal (Refereed) Published
    Abstract [en]

    Daunorubicin and doxorubicin are efficient agents for cancer treatment. Their clinical efficacy is, however, hampered by their indiscriminant toxicity. This problem may be circumvented by encapsulating the drugs in liposomes and selectively targeting the tumor cells using tumor targeting agents. Furthermore, the antitumor effect could be enhanced by attaching the Auger electron emitter, 125I, to daunorubicin an ddoxorubicin derivatives. In this context a number of ester, amide, and amine derivatives of daunorubicin an ddoxorubicin were synthesized. Benzoic acid ester derivatives of daunorubicin were synthesized by nucleophilic esterification of the 14-bromodaunorubicin with the potassium salt of the corresponding benzoic acid, resulting in good yields. Nicotinic acids and benzoic acids, activated with a succinimidyl group, were coupled to the amino group of daunorubicien to give the corresponding amide derivatives. Amine derivatives were obtained by the reductive amination of aromatic aldehydes with daunorubicin hydrochloride. The stannylated ester and amide derivatives were uses as precursors for radioiodination. Radiolabeling with 125I was performed using chloroamine-T as an oxidant. The optimized labeling resulted in high radiolabeling yields (85-95%) of the radioiodinated daunorubicin and doxorubicin derivatives. Radioiodination of the amines was conducted at the ortho position of the activated phenyl rings providing moderate radiochemical yields (55-75%).

    Keywords
    Daunorubicin, Doxorubicin, Radioiodination, 125I, Chloramine-T
    National Category
    Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-70001 (URN)doi:10.1016/j.carres.2004.10.014 (DOI)15620662 (PubMedID)
    Available from: 2006-06-29 Created: 2006-06-29 Last updated: 2017-11-21Bibliographically approved
  • 273.
    Ghirmai, Senait
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Synthesis of Organic Molecules for Nuclide Therapy. Studies on boron cage compounds and 9-aminoacridines2001Licentiate thesis, monograph (Other scientific)
  • 274.
    Ghirmai, Senait
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Malmquist, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Lundquist, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    Sjöberg, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Synthesis and Radioiodination of 7-(3´-Ammoniopropyl)-7,8-dicarba-nido-undecaborate(-1), (ANC)2004In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 47, no 9, p. 557-569Article in journal (Refereed)
    Abstract [en]

    Derivatives of nido-carborate have potential use in tumour targeting as hydrophilic boron-rich compounds for boron neutron capture therapy (BNCT) and as pendant groups for attachment of radiohalogens to tumour-seeking molecules. For this purpose, functionalized derivatives of nido-carborates that can be conjugated to biomolecules should be synthesized and evaluated. In this study, racemic 1, 7-(3′-ammoniopropyl)-7,8-dicarba-nido-undecaborate(-1) (acronym ANC) was obtained by degradation of the corresponding aminopropyl-o-carborane, which was synthesized in three steps from 1-tert-butyldimethylsilyl-2-(3-bromopropyl)-o-carborane, with sodium hydroxide in absolute ethanol. The racemate 1 was radioiodinated (125I) using the Chloramine-T method. Radio-TLC results showed that radiolabelling with 125I was achieved in a yield greater than 95%.

  • 275.
    Ghirmai, Senait
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Mume, Eskender
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Henssen, Cecile
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Ghaneolhusseini, Hadi
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Lundqvist, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
    Sjöberg, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Orlova, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
    Synthesis and Radioiodination of Some 9-Aminoacridine Derivatives2004In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, Vol. 17, p. 3719-3725Article in journal (Refereed)
  • 276.
    Ghirmai, Senait
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Mume, Eskender
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Lundqvist, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
    Sjöberg, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
    Synthesis and radioiodination of some 9-aminoacridine derivatives for potential use in radionuclide therapy2005In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 48, no 12, p. 855-871Article in journal (Refereed)
  • 277.
    Ghirmai, Senait
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Mume, Eskender
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    Sjöberg, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Synthesis and radioiodination of some daunorubicin and doxorubicin derivatives2005In: Carbohydrate Research, ISSN 0008-6215, E-ISSN 1873-426X, Vol. 340, no 1, p. 15-24Article in journal (Refereed)
    Abstract [en]

    Daunorubicin and doxorubicin are efficient agents for cancer treatment. Their clinical efficacy is, however, hampered by their indiscriminant toxicity. This problem may be circumvented by encapsulating the drugs in liposomes and selectively targeting the tumor cells using tumor targeting agents. Furthermore, the antitumor effect could be enhanced by attaching the Auger electron emitter, 125I, to daunorubicin an ddoxorubicin derivatives. In this context a number of ester, amide, and amine derivatives of daunorubicin an ddoxorubicin were synthesized. Benzoic acid ester derivatives of daunorubicin were synthesized by nucleophilic esterification of the 14-bromodaunorubicin with the potassium salt of the corresponding benzoic acid, resulting in good yields. Nicotinic acids and benzoic acids, activated with a succinimidyl group, were coupled to the amino group of daunorubicien to give the corresponding amide derivatives. Amine derivatives were obtained by the reductive amination of aromatic aldehydes with daunorubicin hydrochloride. The stannylated ester and amide derivatives were uses as precursors for radioiodination. Radiolabeling with 125I was performed using chloroamine-T as an oxidant. The optimized labeling resulted in high radiolabeling yields (85-95%) of the radioiodinated daunorubicin and doxorubicin derivatives. Radioiodination of the amines was conducted at the ortho position of the activated phenyl rings providing moderate radiochemical yields (55-75%).

  • 278.
    Gogoll, Adolf
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Grennberg, Helena
    Uppsala University.
    Axen, A
    Uppsala University.
    Chemical shift assignment of geminal protons in 3,7-diazabicyclo [3.3.1]nonanes: An unexpected deviation from the axial/equatorial chemical shift order1997In: Magnetic Resonance in Chemistry, ISSN 0749-1581, E-ISSN 1097-458X, Vol. 35, no 1, p. 13-20p. 13-20Article in journal (Refereed)
    Abstract [en]

    The chemical shift order of axial and equatorial methylene protons in 1,5-disubstituted 3,7-diazabicyclo [3.3.1]nonan-9-ones may be altered by substituents in the 1,5-positions, but the corresponding alcohols behave differently. Unambiguous signal assign

  • 279.
    Gogoll, Adolf
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Grennberg, Helena
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry.
    Axen, Andreas
    Uppsala University.
    (π-Allyl)palladium complexes with N,N'-diphenylbispidinone derivatives as a new type of chelating nitrogen ligand: Complexation studies, spectroscopic properties, and an x-ray structure of (3,7-diphenyl-1,5-dimethylbispidinone)[(1,3-η(3)-propenyl)-pal1997In: Organometallics, ISSN 0276-7333, E-ISSN 1520-6041, Vol. 16, no 6, p. 1167-1178p. 1167-1178Article in journal (Refereed)
    Abstract [en]

    A series of 3,7-diazabicyclo[3.3.1]nonane (bispidine) derivatives have been synthesized, and their properties as bidentate nitrogen ligands for (pi-allyl)palladium complexes have been investigated. Complexes of these ligands and of N,N'-diphenylpiperazin

  • 280.
    Gogoll, Adolf
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Johansson, Charlotte
    Axen, Andreas
    Grennberg, Helena
    Determination of absolute configuration of (pi-allyl)palladium complexes by NMR spectroscopy and stereoselective complexation2001In: Chemistry-A European Journal, ISSN 0947-6539, Vol. 7, no 2, p. 396-403Article in journal (Refereed)
    Abstract [en]

    The chiral chelating ligand N,N'-bis(phenylethyl)bispidine (1) forms a rigid cavity which accommodates (rc-allyl)palladium species with high selectivity In the resulting complex, the absolute configuration of the re-allyl ligand can be determined by the d

  • 281.
    Gogoll, Adolf
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Organisk kemi.
    Toom, Lauri
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Organisk kemi.
    Grennberg, Helena
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I. Organisk kemi.
    Ligand-Induced Formation of an Adamantanoid Hexanuclear (π-Allyl) PdII(μ3-Hydroxo) Cluster Stacked as Hydrogen-Bonded Double Strands2005In: Angew. Chem. Int. Ed., no 44, p. 2295-2300Article in journal (Refereed)
  • 282. Gogoll, Adolf
    et al.
    Toom, Lauri
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Grennberg, Helena
    Ligand-Induced Formation of an Adamantanoid Hexanuclear (π-Allyl)PdII(μ3-Hydroxo) Cluster Stacked as Hydrogen-Bonded Double Strands2005In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 44, no 30, p. 4729-4731Article in journal (Refereed)
  • 283.
    Graves, S W
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Markides, K E
    Hollenberg, N K
    Application of supercritical fluid chromatography to characterize a labile digitalis-like factor2000In: Hypertension, no 36, p. 1059-1064Article in journal (Refereed)
  • 284. Guijarro, David
    et al.
    Pinho, Pedro
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Andersson, Pher
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Enantioselective Addition of Dialkylzinc Reagents to N-(Diphenylphosphinoyl) Imines Promoted by 2-Azanorbornylmethanols1998In: J. Org. Chem., no 63, p. 2530-2535Article in journal (Refereed)
  • 285.
    Guliashvili T, El-Sayed I, Fischer A, Ottosson H.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    The First Isolable 2-Silenolate2003In: Angewandte Chemie Int. Ed., no 42, p. 1640-1642Article in journal (Other scientific)
  • 286.
    Gustavsson, S
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Rosén, A
    Grennberg, H
    Bolton, K.
    Computational Studies of Carbon Nanotube-Hydrocarbon Bond Strengths at Nanotube Ends: Effect of Link Heteroatom and Hydrocarbon Structure2004In: Chemistry - A European Journal, Vol. 10, no 9, p. 2223-2227Article in journal (Refereed)
  • 287.
    Gustavsson, S Å
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Samskog, J
    Markides, K E
    Långström, B
    Studies of signal suppression in liquid chromatography - electrospray ionization mass spectrometry using volatile ion-pairing reagents2001In: J. of Chromatography A, no 937, p. 41-47Article in journal (Refereed)
  • 288.
    Gustavsson, S.Å
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Kato, K.
    Långström, B.
    Purification of 11C-nitromethane for use in asymmetric aldol condensations2003In: J. Labe. Comp. Radiopharmaceuticals, Vol. 46, no 338, p. 1279-1285Article in journal (Refereed)
  • 289.
    Göransson, Kenneth
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Structure and stability trends in the platinum metal-silicon systems1999Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The stability of group 8-10 silicides has been studied by LMTO-ASA band structurecalculations. In the Rh-Si and Ir-Si systems the lowest calculated heat of formation isfound in compounds near the equiatomic composition. Model calculations forsuperstructures in bcc and fcc solid solutions show that in group 8 and 9 silicides thebcc based structures have a maximum in stability near 50% Si. In group 10 systemsthe energy minimum is shifted to lower Si contents and the minimum is less clearlydeveloped.

    The heats of formation in monosilicides are predicted to have a minimum for metalatoms from group 9.

    Calculated one electron densities of states are in good agreement with spectroscopicmeasurements and confirm the generally accepted picture of silicide stability. Themain stabilising factor is metal d - silicon p bonding. With increasing Si contents or group number of the metal atoms dp antibonding states become increasingly filled. A stabilising effect in the highest occupied states is metal-silicon pp interactions and insilicon rich compounds also silicon-silicon pp interactions.

  • 290.
    Hagberg, Lars
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    New synthetic routes to azaspiro alkaloids: Applications to the synthesis perhydrohistrionicotoxin1998Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Perhydrohistrionicotoxin, 1, is related to a family of alkaloids which display pharmacologically interesting properties. The thesis deals with development of new methods for the chemical synthesis of such alkaloids, and is divided into three parts according to the different approaches.

    The first part describes a modification of a previously developed synthesis in which the azaspiro system was formed via an intramolecular ring opening of either an epoxide or an iodonium ion by a nitrogen nucleophile. The alkene precursor of the iodonium ion was synthesised in good overall yield but cyclisation was not accomplished. The epoxide was prepared in good yields but low diastereoselectivity in the epoxidation step rendered this route as a poor alternative.

    The second approach describes the use of a [2,3] sigmatropic rearrangement in combination with a ruthenium-catalysed ring-closing metathesis (RCM) for the synthesis of the azaspiro ring systems. The [2,3] rearrangement of an allylic selenide was completely stereospecific and both azaspiro-[4.5] and [5.5] systems were synthesised by RCM. This methodology was utilised in a formal total synthesis of 1 where a known key intermediate was prepared in 10 steps and 20% overall yield starting from 2,3- epoxycyclohexan-1-one. The synthesis is potentially enantioselective as both enantiomers of the starting material are available in high enantiomeric purity. A possible route to 6-epi-1 was identified by the addition of an allyl boron reagent to an oxime.

    In the third approach a convergent enantioselective total synthesis of 1 is described. The key step was a Lewis acid-promoted, diastereoselective, intramolecular imino ene-type reaction. A highly efficient one-pot, three-component coupling involving two chiral building blocks was used to synthesise the cyclisation precursor. The configurations of the stereogenic centres in the two building blocks originated from kinetic resolutions via Sharpless asymmetric epoxidation of an allylic alcohol. Thesynthesis proceeded in a total yield of 11% involving 10 laboratory operations starting from 1-bromo-3-((tert-butyldimethylsilyl)oxy)-propane.

  • 291.
    Haggstrom, L
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics.
    James, P
    Chemistry, Department of Chemistry.
    Eriksson, O
    Liu, HP
    Trosko, M
    Szymanski, K
    Dobrzynski, L
    Hyperfine interaction study of (Fe1-xCox)(3)P compounds2000In: PHYSICAL REVIEW B, ISSN 1098-0121, Vol. 61, no 10, p. 6798-6804Article in journal (Refereed)
    Abstract [en]

    The magnetic and ordering properties of (Fe1-xCox)(3)P (x=0, 0.1, 0.2, and 0.33) compounds have been studied by Fe-57 Mossbauer technique. These investigations show that Co preferentially substitutes Fe in two out of three metal sites. Variations of the m

  • 292.
    Hagman, Charlotte
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Technology, Department of Engineering Sciences. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Technology, Department of Engineering Sciences, Ion Physics. Jonfysik.
    Ramström, Margareta
    Chemistry, Department of Chemistry. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Technology, Department of Engineering Sciences, Ion Physics. analytisk kemi.
    Håkansson, Per
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Technology, Department of Engineering Sciences. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Technology, Department of Engineering Sciences, Ion Physics. Jonfysik.
    Bergquist, Jonas
    Chemistry, Department of Chemistry. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Technology, Department of Engineering Sciences, Ion Physics. Analytisk kemi.
    Quantitative analysis of tryptic protein mixtures using electrospray ionization fourier transform ion cyclotron resonance mass spectrometry2004In: Journal of proteome research, no 3, p. 587-594Article in journal (Refereed)
  • 293.
    Hansson, M
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Arvidsson, P.I
    Nilsson, Lill S.O
    Ahlberg, P.
    3Stereoselective Solvent Induced 1,3-proton Transfer of an Allylic Alkoxide to a Homoallylic Alkoxide Catalyzed by a Chiral Lithium Amide22002In: Perkin Trans. 2, p. 763-767Article in journal (Other scientific)
  • 294.
    Harden, Adrian
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Synthesis and Applications of C2-Symmetric Bis (Aziridines) in Asymmetric Synthesis2000Licentiate thesis, monograph (Other scientific)
  • 295. Hardenborg, Emilia
    et al.
    Zuberovic, Aida
    Ullsten, Sara
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Söderberg, Lennart
    Heldin, Eva
    Markides, Karin
    A novel polyamine coating providing non-covalent deactivation and reversed electroosmotic flow of fused-silica capillaries for capillary electrophoresis2003In: Journal of Chromatography A, Vol. 1003, no 1-2, p. 217-221Article in journal (Refereed)
  • 296.
    Hardenborg, Emilia
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Zuberovic, Aida
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Ullsten, Sara
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Söderberg, Lennart
    Surface Biotechnology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Physical and Analytical Chemistry.
    Heldin, Eva
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Markides, Karin
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Novel polyamine coating providing non-covalent deactivation and reversed electroosmotic flow of fused-silica capillaries for capillary electrophoresis2003In: J. of Chromatography A, no 1003, p. 217-221Article in journal (Refereed)
  • 297. Hartikka, A.
    et al.
    Modin, S. A.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Andersson, P. G.
    Arvidsson, P. I.
    Cinchona alkaloid derived ligands in catalytic asymmetric transfer hydrogenation2003In: Organic & Biomolecular Chemistry, ISSN 1477-0539, Vol. 1, no 14, p. 2522-2526Article in journal (Refereed)
  • 298.
    Hartikka, A
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Modin, S
    Andersson, P.G
    Arvidsson, P.I.
    Cinchona Alkaloid derived Ligands in Catalytic Asymmetric Transfer Hydrogenation2003In: Org. Biomol. Chem., no 1, p. 2522-Article in journal (Refereed)
  • 299.
    Hartikka, Antti
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Organisk kemi.
    Arvidsson, Per
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Rational design of asymmetric organocatalysts-increased reactivity and solvent scope with a tetrazolic acid2004In: Tetrahedron Asymmetry, Vol. 15, p. 1831-1834Article in journal (Refereed)
    Abstract [en]

    Replacement of the carboxylic acid functionality in the widely used organocatalyst proline with a tetrazolic acid leads to a catalyst with increased reactivity and solvent scope, as demonstrated in the direct catalytic asymmetric aldol reaction.

  • 300.
    Hartvig, P
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Bergström, M
    Antoni, Gunnar
    Långström, B.
    Positron Emission Tomography and brain Monoamine neurotransmission-Entries for study drug interactions2002In: Current Pharmaceutical Design, no 8, p. 1417-1434Article in journal (Other academic)
3456789 251 - 300 of 851
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