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  • 251. Vasan, Ramachandran S
    et al.
    Evans, Jane C
    Benjamin, Emelia J
    Levy, Daniel
    Larson, Martin G
    Sundström, Johan
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap. Institutionen för medicinska vetenskaper.
    Murabito, Joanne M
    Sam, Flora
    Colucci, Wilson S
    Wilson, Peter W F
    Relations of serum aldosterone to cardiac structure: gender-related differences in the Framingham Heart Study.2004Inngår i: Hypertension, ISSN 1524-4563, Vol. 43, nr 5, s. 957-62Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aldosterone is associated with myocardial fibrosis in experimental studies and with left ventricular remodeling in heart failure patients. We hypothesized that aldosterone influences ventricular remodeling in people without congestive heart failure in the community. We examined the relations between serum aldosterone and echocardiographic left ventricular measurements in 2820 Framingham Study subjects (mean age 57 years, 58% women, 88% white) free of myocardial infarction and overt heart failure. Serum aldosterone levels were higher in women compared with men. In linear regression models (adjusted for age, systolic blood pressure, weight, height, diabetes, heart rate, hypertension treatment, and ethnicity), left ventricular wall thickness and relative wall thickness were positively related, and left ventricular diastolic dimensions were inversely related to serum aldosterone in women (P<0.05 for all), but not in men (P>0.20 for all). There was no effect modification of the relations observed in women by menopausal status. The gender-related differences in relations of serum aldosterone to relative wall thickness were consistent across subgroups defined on the basis of sex-specific median values of systolic blood pressure and body mass index. Fractional shortening, left ventricular mass, and left atrial dimensions were not related to serum aldosterone in either sex. In conclusion, in our community-based sample of individuals free of myocardial infarction and heart failure, serum aldosterone was positively associated with a left ventricular geometric pattern suggestive of concentric remodeling (increased left ventricular wall thickness and relative wall thickness but decreased internal dimensions) in women but not in men. Additional investigations are warranted to confirm these findings.

  • 252. Vasan, Ramachandran S
    et al.
    Sullivan, Lisa M
    Wilson, Peter W F
    Sempos, Christopher T
    Sundstrom, Johan
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Kannel, William B
    Levy, Daniel
    D'Agostino, Ralph B
    Relative importance of borderline and elevated levels of coronary heart disease risk factors.2005Inngår i: Ann Intern Med, ISSN 1539-3704, Vol. 142, nr 6, s. 393-402Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Clinical trials indicate that a sizable proportion of adults have multiple borderline coronary risk factors and may benefit from treatment. OBJECTIVE: To estimate the relative and absolute contributions of borderline and elevated risk factors to the population burden of coronary heart disease (CHD) events. DESIGN: A prospective cohort study and a national cross-sectional survey. SETTING: The Framingham Study and the Third National Health and Nutrition Examination Survey (NHANES III). PARTICIPANTS: White non-Hispanic persons in the Framingham Study and in NHANES III who were between 35 to 74 years of age and had no CHD. MEASUREMENTS: Occurrence of first CHD events according to 5 major CHD risk factors: blood pressure, low-density lipoprotein and high-density lipoprotein cholesterol levels, glucose intolerance, and smoking. Three categories-optimal, borderline, and elevated-were defined for each risk factor per national guidelines. Sex-specific 10-year CHD event rates from the Framingham Study were applied to numbers of at-risk individuals estimated from NHANES III and the 2000 U.S. Census. RESULTS: Twenty-six percent of men and 41% of women had at least 1 borderline risk factor in NHANES III. According to estimates, more than 90% of CHD events will occur in individuals with at least 1 elevated risk factor, and approximately 8% will occur in people with only borderline levels of multiple risk factors. Absolute 10-year CHD risk exceeded 10% in men older than age 45 years who had 1 elevated risk factor and 4 or more borderline risk factors and in those who had at least 2 elevated risk factors. In women, absolute CHD risk exceeded 10% only in those older than age 55 years who had at least 3 elevated risk factors. LIMITATIONS: The generalizability of the findings to persons of other ethnic backgrounds is unknown. CONCLUSIONS: Borderline CHD risk factors alone account for a small proportion of CHD events.

  • 253. Velagaleti, Raghava S.
    et al.
    Gona, Philimon
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).
    Larson, Martin G.
    Siwik, Deborah
    Colucci, Wilson S.
    Benjamin, Emelia J.
    Vasan, Ramachandran S.
    Relations of biomarkers of extracellular matrix remodeling to incident cardiovascular events and mortality2010Inngår i: Arteriosclerosis, Thrombosis and Vascular Biology, ISSN 1079-5642, E-ISSN 1524-4636, Vol. 30, nr 11, s. 2283-2288Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE-: To evaluate if biomarkers reflecting left ventricular/vascular extracellular matrix remodeling are associated with cardiovascular disease (CVD) and death in the community. METHODS AND RESULTS-: In 922 Framingham Study participants (mean age, 58 years; 56% women), we related circulating concentrations of matrix metalloproteinase-9 (binary variable: detectable versus undetectable), log of tissue inhibitor of matrix metalloproteinase-1, and log of procollagen type III aminoterminal peptide (PIIINP) to incident CVD and death. On follow-up (mean, 9.9 years), 51 deaths and 81 CVD events occurred. Each SD increment of log of tissue inhibitor of matrix metalloproteinase-1 and log-PIIINP was associated with multivariable-adjusted hazards ratios of 1.72 (95% CI, 1.30 to 2.27) and 1.47 (95% CI, 1.11 to 1.96), respectively, for mortality risk. Log-PIIINP concentrations were also associated with CVD risk (hazard ratio [95% CI] per SD, 1.35 [1.05 to 1.74]). Death and CVD incidence rates were 2-fold higher in participants with both biomarkers higher than the median (corresponding hazard ratio [95% CI], 2.78 [1.43 to 5.40] and 1.77 [1.04 to 3.03], respectively) compared with those with either or both less than the median. The inclusion of both biomarkers improved the C-statistic (for predicting mortality) from 0.78 to 0.82 (P=0.03). Matrix metalloproteinase-9 was unrelated to either outcome. CONCLUSION-: Higher circulating tissue inhibitor of matrix metalloproteinase-1 and PIIINP concentrations are associated with mortality, and higher PIIINP is associated with incident CVD, in the community.

  • 254.
    Wain, Louise V.
    et al.
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Vaez, Ahmad
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Tehran, Iran..
    Jansen, Rick
    Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Neurosci Campus Amsterdam, Amsterdam, Netherlands..
    Joehanes, Roby
    Harvard Med Sch, Hebrew SeniorLife, Boston, MA USA.;Framingham Heart Dis Epidemiol Study, Natl Heart Lung & Blood Inst, Framingham, MA USA..
    van der Most, Peter J.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Erzurumluoglu, A. Mesut
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    O'Reilly, Paul F.
    Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England. Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England..
    Cabrera, Claudia P.
    William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England..
    Warren, Helen R.
    William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England..
    Rose, Lynda M.
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA..
    Verwoert, Germaine C.
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
    Hottenga, Jouke-Jan
    Vrije Univ, VU Univ Med Ctr, EMGO Inst, Dept Biol Psychol, Amsterdam, Netherlands..
    Strawbridge, Rona J.
    Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ, Ctr Mol Med, Solna, Sweden..
    Esko, Tonu
    Childrens Hosp, Div Endocrinol, Boston, MA USA.;Broad Inst Harvard & MIT, Cambridge, MA USA..
    Arking, Dan E.
    Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Sch Med, Baltimore, MD USA..
    Hwang, Shih-Jen
    NHLBI, Populat Sci Branch, Div Intramural Res, Bldg 10, Bethesda, MD 20892 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA..
    Guo, Xiuqing
    Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA USA..
    Kutalik, Zoltan
    Univ Lausanne Hosp, Inst Social & Prevent Med, Lausanne, Switzerland.;Swiss Inst Bioinformat, Lausanne, Switzerland..
    Trompet, Stella
    Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands..
    Shrine, Nick
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Teumer, Alexander
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Greifswald, Germany..
    Ried, Janina S.
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Munich, Germany..
    Bis, Joshua C.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA..
    Smith, Albert V.
    Icelandic Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Amin, Najaf
    Erasmus MC, Genet Epidemiol Unit, Dept Epidemiol, Rotterdam, Netherlands..
    Nolte, Ilja M.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Lyytikainen, Leo-Pekka
    Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Tampere, Finland..
    Mahajan, Anubha
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Wareham, Nicholas J.
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge, England..
    Hofer, Edith
    Med Univ Graz, Clin Div Neurogeriatr, Dept Neurol, Graz, Austria.;Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria..
    Joshi, Peter K.
    Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland..
    Kristiansson, Kati
    Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland..
    Traglia, Michela
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Havulinna, Aki S.
    Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland..
    Goel, Anuj
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford, England..
    Nalls, Mike A.
    NIA, Neurogenet Lab, Bethesda, MD 20892 USA.;Data Tecn Int, Glen Echo, MD USA..
    Sober, Siim
    Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia..
    Vuckovic, Dragana
    IRCCS Burlo Garofolo Children Hosp, Med Genet, Trieste, Italy.;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Luan, Jian'an
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge, England..
    Del Greco M, Fabiola
    Univ Lubeck, Inst Biomed, Affiliated Inst, Eurac Res, Bolzano, Italy..
    Ayers, Kristin L.
    Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA.;Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY USA..
    Marrugat, Jaume
    IMIM, Cardiovasc Epidemiol & Genet, Barcelona, Spain.;CIBERCV, Barcelona, Spain..
    Ruggiero, Daniela
    CNR, Inst Genet & Biophys A Buzzati Traverso, Naples, Italy..
    Lopez, Lorna M.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Beaumont Hosp, Dept Psychiat, Royal Coll Surg Ireland, Educ & Res Ctr, Dublin, Ireland.;Univ Coll Dublin, UCD Conway Inst, Ctr Proteome Res, Belfield, Ireland.;Univ Coll Dublin, Sch Med, Conway Inst, Belfield, Ireland..
    Niiranen, Teemu
    Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland..
    Enroth, Stefan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Jackson, Anne U.
    Univ Michigan, Dept Biostat, Ann Arbor, MI USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI USA..
    Nelson, Christopher P.
    Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Univ Leicester, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland..
    Huffman, Jennifer E.
    Univ Edinburgh, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland..
    Zhang, Weihua
    Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England.;London North West Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, Southall, Middx, England..
    Marten, Jonathan
    Univ Edinburgh, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland..
    Gandin, Ilaria
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Harris, Sarah E.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, Med Genet Sect, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland..
    Zemunik, Tatijana
    London North West Healthcare NHS Trust, Dept Med Biol, Fac Med, Southall, Middx, England..
    Lu, Yingchang
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY USA..
    Evangelou, Evangelos
    Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece..
    Shah, Nabi
    Univ Dundee, Med Res Inst, Ninewells Hosp, Dundee, Scotland.;Univ Dundee, Sch Med, Dundee, Scotland.;COMSATS Inst Informat Technol, Dept Pharm, Abbottabad, Pakistan..
    de Borst, Martin H.
    Univ Groningen, Univ Med Ctr Groningen, Div Nephrol, Dept Internal Med, Groningen, Netherlands..
    Mangino, Massimo
    Natl Inst Hlth Res, Biomed Res Ctr, London, England..
    Prins, Bram P.
    Wellcome Trust Sanger Inst, Dept Human Genet, London, England..
    Campbell, Archie
    Univ Edinburgh, Med Genet Sect, Ctr Genom & Expt Med, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Med Genet Sect, Ctr Genom & Expt Med, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Generat Scotland, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland..
    Li-Gao, Ruifang
    Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands..
    Chauhan, Ganesh
    Bordeaux Populat Hlth Ctr, INSERM U 1219, Bordeaux, France.;Bordeaux Univ, Bordeaux, France..
    Oldmeadow, Christopher
    Hunter Med Res Inst, New Lambton, NSW, Australia..
    Abecasis, Goncalo
    Ctr Stat Genet, Dept Biostat, Ann Arbor, MI USA..
    Abedi, Maryam
    Isfahan Univ Med Sci, Dept Genet & Mol Biol, Esfahan, Iran..
    Barbieri, Caterina M.
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Barnes, Michael R.
    William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England..
    Batini, Chiara
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Beilby, John
    Busselton Populat Med Res Inst, Nedlands, WA, Australia.;PathWest Lab Med Western Australia, Nedlands, WA, Australia.;Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA, Australia..
    Blake, Tineka
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Boehnke, Michael
    Univ Michigan, Dept Biostat, Ann Arbor, MI USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI USA..
    Bottinger, Erwin P.
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY USA..
    Braund, Peter S.
    Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Univ Leicester, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland..
    Brown, Morris
    William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England..
    Brumat, Marco
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Campbell, Harry
    Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland..
    Chambers, John C.
    Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England.;London North West Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, Southall, Middx, England.;Imperial Coll Healthcare NHS Trust, London, England..
    Cocca, Massimiliano
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Collins, Francis
    NHGRI, Med Genom & Metab Genet Branch, Bethesda, MD 20892 USA..
    Connell, John
    Univ Dundee, Ninewells Hosp & Med Sch, Dundee, Scotland..
    Cordell, Heather J.
    Newcastle Univ, Inst Med Genet, Newcastle Upon Tyne, Tyne & Wear, England..
    Damman, Jeffrey J.
    Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands..
    Davies, Gail
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    de Geus, Eco J.
    Vrije Univ, VU Univ Med Ctr, EMGO Inst, Dept Biol Psychol, Amsterdam, Netherlands..
    de Mutsert, Renee
    Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands..
    Deelen, Joris
    Leiden Univ, Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands..
    Demirkale, Yusuf
    NIH, Ctr Informat Technol, Bldg 10, Bethesda, MD 20892 USA..
    Doney, Alex S. F.
    Univ Dundee, Med Res Inst, Ninewells Hosp, Dundee, Scotland.;Univ Dundee, Sch Med, Dundee, Scotland..
    Dorr, Marcus
    Univ Med Greifswald, Dept Internal Med, Greifswald, Germany.;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Greifswald, Germany..
    Farrall, Martin
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford, England..
    Ferreira, Teresa
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Franberg, Mattias
    Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ, Ctr Mol Med, Solna, Sweden.;Stockholm Univ, Dept Numer Anal & Comp Sci, Stockholm, Sweden..
    Gao, He
    Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England..
    Giedraitis, Vilmantas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Gieger, Christian
    Forschungszentrum Gesundheit & Umwelt GmbH, Neuherberg, Germany..
    Giulianini, Franco
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA..
    Gow, Alan J.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Heriot Watt Univ, Sch Social Sci, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Hamsten, Anders
    Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ, Ctr Mol Med, Solna, Sweden..
    Harris, Tamara B.
    NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA..
    Hofman, Albert
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA..
    Holliday, Elizabeth G.
    Hunter Med Res Inst, New Lambton, NSW, Australia..
    Hui, Jennie
    Busselton Populat Med Res Inst, Nedlands, WA, Australia.;PathWest Lab Med Western Australia, Nedlands, WA, Australia.;Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA, Australia.;Univ Western Australia, Sch Populat & Global Hlth, Nedlands, WA, Australia..
    Jarvelin, Marjo-Riitta
    Imperial Coll London, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England.;Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland.;Univ Oulu, Bioctr Oulu, Oulu, Finland.;Oulu Univ Hosp, Unit Primary Care, Oulu, Finland..
    Johansson, Åsa
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik.
    Johnson, Andrew D.
    Framingham Heart Dis Epidemiol Study, Natl Heart Lung & Blood Inst, Framingham, MA USA.;NHLBI, Cardiovasc Epidemiol & Human Genom Branch, Bldg 10, Bethesda, MD 20892 USA..
    Jousilahti, Pekka
    Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland..
    Jula, Antti
    Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland..
    Kahonen, Mika
    Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Univ Tampere, Dept Clin Physiol, Fac Med & Life Sci, Tampere, Finland..
    Kathiresan, Sekar
    Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA..
    Khaw, Kay-Tee
    Univ Cambridge, Dept Publ Hlth & Primary Care, Inst Publ Hlth, Cambridge, England..
    Kolcic, Ivana
    Univ Split, Dept Publ Hlth, Fac Med, Split, Croatia..
    Koskinen, Seppo
    Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland..
    Langenberg, Claudia
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge, England..
    Larson, Marty
    Framingham Heart Dis Epidemiol Study, Natl Heart Lung & Blood Inst, Framingham, MA USA..
    Launer, Lenore J.
    NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA..
    Lehne, Benjamin
    Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England..
    Liewald, David C. M.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Lin, Li
    Univ Hosp Geneva, Dept Med Specialties, Cardiol, Geneva, Switzerland..
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Mach, Francois
    Univ Hosp Geneva, Dept Med Specialties, Cardiol, Geneva, Switzerland..
    Mamasoula, Chrysovalanto
    Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne, Tyne & Wear, England..
    Menni, Cristina
    Mifsud, Borbala
    William Harvey Res Inst, Clin Pharmacol, London, England..
    Milaneschi, Yuri
    Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Dept Psychiat, Amsterdam, Netherlands..
    Morgan, Anna
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Morris, Andrew D.
    Univ Edinburgh, Sch Mol Genet & Populat Hlth Sci, Sch Med, Teviot Pl, Edinburgh, Midlothian, Scotland..
    Morrison, Alanna C.
    Univ Texas Hlth Sci Ctr Houston, Dept Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Houston, TX USA..
    Munson, Peter J.
    NIH, Ctr Informat Technol, Bldg 10, Bethesda, MD 20892 USA..
    Nandakumar, Priyanka
    Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Sch Med, Baltimore, MD USA..
    Nguyen, Quang Tri
    Nutile, Teresa
    CNR, Inst Genet & Biophys A Buzzati Traverso, Naples, Italy..
    Oldehinkel, Albertine J.
    Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands..
    Oostra, Ben A.
    Erasmus MC, Genet Epidemiol Unit, Dept Epidemiol, Rotterdam, Netherlands..
    Org, Elin
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia..
    Padmanabhan, Sandosh
    Univ Edinburgh, Generat Scotland, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland.;Univ Glasgow, British Heart Fdn, Glasgow Cardiovasc Res Ctr, Inst Cardiovasc & Med Sci,Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland.;Univ Glasgow, Inst Cardiovasc & Med Sci, Fac Med, Glasgow, Lanark, Scotland..
    Palotie, Aarno
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland..
    Pare, Guillaume
    McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada..
    Pattie, Alison
    Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Penninx, Brenda W. J. H.
    Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Dept Psychiat, Amsterdam, Netherlands..
    Poulter, Neil
    Imperial Coll London, Sch Publ Hlth, London, England..
    Pramstaller, Peter P.
    Univ Lubeck, Inst Biomed, Affiliated Inst, Eurac Res, Bolzano, Italy.;Dept Neurol, Gen Cent Hosp, Bolzano, Italy.;Univ Lubeck, Dept Neurol, Lubeck, Germany..
    Raitakari, Olli T.
    Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland..
    Ren, Meixia
    William Harvey Res Inst, Clin Pharmacol, London, England.;Fujian Med Univ, Fujian Prov Hosp, Dept Cardiol, Fuzhou, Fujian, Peoples R China..
    Rice, Kenneth
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA..
    Ridker, Paul M.
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA..
    Riese, Harriette
    Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands..
    Ripatti, Samuli
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland..
    Robino, Antonietta
    Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Trieste, Italy..
    Rotter, Jerome I.
    Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat & Med, LABioMed, Torrance, CA USA..
    Rudan, Igor
    Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland..
    Saba, Yasaman
    Med Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, Graz, Austria..
    Saint Pierre, Aude
    Univ Lubeck, Inst Biomed, Affiliated Inst, Eurac Res, Bolzano, Italy.;INSERM U1078, Etab Francais Sang, Brest, France..
    Sala, Cinzia F.
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Sarin, Antti-Pekka
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland..
    Schmidt, Reinhold
    Med Univ Graz, Clin Div Neurogeriatr, Dept Neurol, Graz, Austria..
    Scott, Rodney
    Hunter Med Res Inst, New Lambton, NSW, Australia.;Univ Newcastle, Fac Hlth, Callaghan, NSW, Australia.;John Hunter Hosp, New Lambton, NSW, Australia..
    Seelen, Marc A.
    Univ Groningen, Univ Med Ctr Groningen, Div Nephrol, Dept Internal Med, Groningen, Netherlands..
    Shields, Denis C.
    Univ Coll Dublin, Sch Med, Conway Inst, Belfield, Ireland..
    Siscovick, David
    New York Acad Med, New York, NY USA..
    Sorice, Rossella
    CNR, Inst Genet & Biophys A Buzzati Traverso, Naples, Italy.;IRCCS Neuromed, Pozzilli, Isernia, Italy..
    Stanton, Alice
    Royal Coll Surgeons Ireland, Mol & Cellular Therapeut, Dublin 2, Ireland..
    Stott, David J.
    Univ Glasgow, Inst Cardiovasc & Med Sci, Fac Med, Glasgow, Lanark, Scotland..
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Swertz, Morris
    Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands..
    Taylor, Kent D.
    Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Los Angeles BioMed Res Inst, Torrance, CA USA.;Harbor UCLA Med Ctr, Div Genet Outcomes, Dept Pediat, Torrance, CA USA..
    Thom, Simon
    Imperial Coll London, Int Ctr Circulatory Hlth, London, England..
    Tzoulaki, Ioanna
    Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England..
    Tzourio, Christophe
    Bordeaux Populat Hlth Ctr, INSERM U 1219, Bordeaux, France.;Bordeaux Univ, Bordeaux, France.;Bordeaux Univ Hosp, Dept Publ Hlth, Bordeaux, France.;Bordeaux Univ Hosp, Dept Neurol, Bordeaux, France..
    Uitterlinden, Andre G.
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands..
    Volker, Uwe
    Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Greifswald, Germany..
    Vollenweider, Peter
    Univ Lausanne Hosp, CHUV, Dept Internal Med, Lausanne, Switzerland..
    Wild, Sarah
    Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland..
    Willemsen, Gonneke
    Vrije Univ, VU Univ Med Ctr, EMGO Inst, Dept Biol Psychol, Amsterdam, Netherlands..
    Wright, Alan F.
    Univ Edinburgh, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland..
    Yao, Jie
    Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA USA..
    Theriault, Sebastien
    McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada..
    Conen, David
    McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada..
    Attia, John
    Hunter Med Res Inst, New Lambton, NSW, Australia.;Univ Newcastle, Fac Hlth, Callaghan, NSW, Australia.;John Hunter Hosp, New Lambton, NSW, Australia..
    Sever, Peter
    Imperial Coll London, Natl Heart & Lung Inst, London, England..
    Debette, Stephanie
    Bordeaux Populat Hlth Ctr, INSERM U 1219, Bordeaux, France.;Bordeaux Univ, Bordeaux, France.;Bordeaux Univ Hosp, Dept Neurol, Bordeaux, France..
    Mook-Kanamori, Dennis O.
    Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands..
    Zeggini, Eleftheria
    Wellcome Trust Sanger Inst, Dept Human Genet, London, England..
    Spector, Tim D.
    van der Harst, Pim
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands..
    Palmer, Colin N. A.
    Univ Dundee, Med Res Inst, Ninewells Hosp, Dundee, Scotland.;Univ Dundee, Sch Med, Dundee, Scotland..
    Vergnaud, Anne-Claire
    Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England..
    Loos, Ruth J. F.
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge, England.;Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth Dev Inst, New York, NY USA..
    Polasek, Ozren
    Univ Split, Dept Publ Hlth, Fac Med, Split, Croatia..
    Starr, John M.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh, Midlothian, Scotland..
    Girotto, Giorgia
    IRCCS Burlo Garofolo Children Hosp, Med Genet, Trieste, Italy.;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Hayward, Caroline
    Univ Edinburgh, Generat Scotland, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, MRC, Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland..
    Kooner, Jaspal S.
    London North West Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, Southall, Middx, England.;Imperial Coll Healthcare NHS Trust, London, England.;Imperial Coll London, Natl Heart & Lung Inst, Hammersmith Hosp Campus, London, England..
    Lindgren, Cecila M.
    Broad Inst Harvard & MIT, Cambridge, MA USA.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Vitart, Veronique
    Univ Edinburgh, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland..
    Samani, Nilesh J.
    Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Univ Leicester, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland..
    Tuomilehto, Jaakko
    Dasman Diabet Inst, Kuwait, Kuwait.;King Abdulaziz Univ, Diabet Res Grp, Jeddah, Saudi Arabia.;Danube Univ Krems, Dept Neurosci & Prevent Med, Krems An Der Donau, Austria. Univ Manchester, Div Cardiovasc Sci, Manchester, Lancs, England..
    Gyllensten, Ulf
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik.
    Knekt, Paul
    Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland..
    Deary, Ian J.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Ciullo, Marina
    CNR, Inst Genet & Biophys A Buzzati Traverso, Naples, Italy.;IRCCS Neuromed, Pozzilli, Isernia, Italy..
    Elosua, Roberto
    IMIM, Cardiovasc Epidemiol & Genet, Barcelona, Spain.;CIBERCV, Barcelona, Spain..
    Keavney, Bernard D.
    Cent Manchester Univ Hosp NHS Fdn Trust, Manchester, Lancs, England..
    Hicks, Andrew A.
    Univ Lubeck, Inst Biomed, Affiliated Inst, Eurac Res, Bolzano, Italy..
    Scott, Robert A.
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge, England..
    Gasparini, Paolo
    IRCCS Burlo Garofolo Children Hosp, Med Genet, Trieste, Italy.;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Laan, Maris
    Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia..
    Liu, YongMei
    Wake Forest Sch Med, Div Publ Hlth Sci, Winston Salem, NC USA..
    Watkins, Hugh
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford, England..
    Hartman, Catharina A.
    Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands..
    Salomaa, Veikko
    Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland..
    Toniolo, Daniela
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Perola, Markus
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland.;Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland..
    Wilson, James F.
    Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland..
    Schmidt, Helena
    Med Univ Graz, Dept Neurol, Graz, Austria.;Med Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, Graz, Austria..
    Zhao, Jing Hua
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge, England..
    Lehtimaki, Terho
    Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Tampere, Finland..
    van Duijn, Cornelia M.
    Erasmus MC, Genet Epidemiol Unit, Dept Epidemiol, Rotterdam, Netherlands..
    Gudnason, Vilmundur
    Icelandic Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Psaty, Bruce M.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.;Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA.;Kaiser Permanent, Washington Hlth Res Inst, Seattle, WA USA..
    Peters, Annette
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Munich, Germany..
    Rettig, Rainer
    Univ Med Greifswald, Inst Physiol, Karlsburg, Germany..
    James, Alan
    Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA, Australia.;Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep, Nedlands, WA, Australia..
    Jukema, J. Wouter
    Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands..
    Strachan, David P.
    St Georges Univ London, Populat Hlth Res Inst, London, England..
    Palmas, Walter
    Columbia Univ, Dept Med, Med Ctr, New York, NY USA..
    Metspalu, Andres
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia..
    Ingelsson, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Boomsma, Dorret I.
    Vrije Univ, VU Univ Med Ctr, EMGO Inst, Dept Biol Psychol, Amsterdam, Netherlands..
    Franco, Oscar H.
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
    Bochud, Murielle
    Univ Lausanne Hosp, Inst Social & Prevent Med, Lausanne, Switzerland..
    Newton-Cheh, Christopher
    Broad Inst Harvard & MIT, Cambridge, MA USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA..
    Munroe, Patricia B.
    William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England..
    Elliott, Paul
    Imperial Coll London, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England..
    Chasman, Daniel I.
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA..
    Chakravarti, Aravinda
    Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Sch Med, Baltimore, MD USA..
    Knight, Joanne
    Univ Lancaster, Data Sci Inst, Lancaster, England.;Univ Lancaster, Lancaster Med Sch, Lancaster, England..
    Morris, Andrew P.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England..
    Levy, Daniel
    NHLBI, Populat Sci Branch, Div Intramural Res, Bldg 10, Bethesda, MD 20892 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA..
    Tobin, Martin D.
    Snieder, Harold
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Caulfield, Mark J.
    William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England..
    Ehret, Georg B.
    Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Sch Med, Baltimore, MD USA.;Univ Hosp Geneva, Dept Med Specialties, Cardiol, Geneva, Switzerland..
    Alistair, T. Y.
    Betholdson, J. -P
    Xiao, Limin
    Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney2017Inngår i: Hypertension, ISSN 0194-911X, E-ISSN 1524-4563, Vol. 70, nr 3, s. E4-e19Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.

  • 255. Wang, TJ
    et al.
    Larsson, MG
    Benjamin, EJ
    Siwik, DA
    Safa, R
    Guo, CY
    Corey, D
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Sawyer, DB
    Colucci, WS
    Vasan, RS
    Clinical and echocardiographic correlates of plasma procollagen type III amino-terminal peptide levels in the community2007Inngår i: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 154, nr 2, s. 291-297Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    Left ventricular remodeling is characterized by increased collagen deposition in the extracellular matrix. Levels of plasma procollagen type III amino-terminal peptide (PIIINP), a marker of collagen turnover, are elevated in the setting of recent myocardial infarction, heart failure, and cardiomyopathy. Whether plasma PIIINP levels are a useful indicator of subclinical left ventricular abnormalities in ambulatory individuals has not been studied.

    Methods

    We examined 967 Framingham Heart Study participants (mean age, 56 years; 60% women) who underwent routine echocardiography and measurement of plasma PIIINP levels. All participants were free of prior myocardial infarction or heart failure. Multivariable regression analyses were performed to examine the clinical and echocardiographic correlates of PIIINP levels.

    Results

    Plasma PIIINP levels increased with age and body mass index but did not significantly correlate with other cardiovascular risk factors including hypertension and diabetes. In multivariable models, there was no association between plasma PIIINP levels and left ventricular mass (P = .89), left ventricular fractional shortening (P = .15), left ventricular end-diastolic dimension (P = .51), or left atrial size (P = .68). Plasma PIIINP levels were positively correlated with tissue inhibitor of metalloproteinase-1 levels (multivariable-adjusted, P = .001).

    Conclusions

    The use of biomarkers of extracellular matrix turnover has generated recent interest, with plasma PIIINP being the most commonly studied biomarker in acute settings. However, our findings in a large, community-based cohort suggest that plasma PIIINP has limited use for the detection of structural heart disease in ambulatory individuals.

  • 256.
    Warensjö, Eva
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Klinisk nutrition och metabolism.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Vessby, Bengt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Klinisk nutrition och metabolism.
    Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men2006Inngår i: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 84, nr 2, s. 442-448Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: A specific fatty acid (FA) composition in plasma lipid esters is related to the metabolic syndrome (MetS) and may influence the development of the MetS.

    Objective: The objective was to define and study FA factors as measures of dietary fat quality and endogenous FA metabolism in relation to MetS.

    Design: Principal factor analysis was performed to define specific FA factors in men participating in a population-based cohort study the Uppsala Longitudinal Study of Adult Men. The factors were generated at ages 50 (n = 2009) and 70 (n = 576) y, and relations between FA factors and MetS (National Cholesterol Education Program) were studied in cross-sectional and prospective (20 y) analyses.

    Results: The factor analysis generated 3 major FA factors: a low-linoleic acid (LA) factor, a dietary saturated FA factor, and an n-3 polyunsaturated FA (PUFA) factor. All factors differed between those subjects with MetS (n = 281 of 2009) and those without MetS at age 50 y; only the low-LA factor differed at age 70 y, which suggests an association between MetS and fat quality. The low-LA factor (odds ratio: 1.51;95% CI: 1.28,1.79;P < 0.0001) and the n-3 PUFA factor (0.76; 0.64, 0.90; P < 0.001) predicted MetS development over 20 y, independent of smoking habits, physical activity, and BMI.

    Conclusions: The generated FA factors, which presumably represent dietary fat quality and endogenous FA metabolism, may be important in the development of MetS. This finding supports current dietary recommendations to increase PUFA intakes and restrict saturated FA intakes.

  • 257.
    Warensjö, Eva
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Klinisk nutrition och metabolism.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Vessby, Bengt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Klinisk nutrition och metabolism.
    Cederholm, Tommy
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Klinisk nutrition och metabolism.
    Risérus, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Klinisk nutrition och metabolism.
    Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study2008Inngår i: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 88, nr 1, s. 203-209Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Desaturase indexes, as markers of endogenous fatty acid desaturation, and a characteristic serum fatty acid (FA) composition are related to cardiovascular and metabolic diseases, but the relation to mortality is poorly investigated. OBJECTIVE: The objective was to evaluate the relation between dietary fat biomarkers, desaturase indexes, and mortality. DESIGN: In this community-based prospective sample, 50-y-old men were followed for a maximum of 33.7 y. Cox proportional hazard analysis was conducted to investigate desaturase indexes (stearoyl-CoA-desaturase and Delta(6)- and Delta(5)-desaturase) and the relation of individual serum esterified fatty acids (FAs) in relation to total and cardiovascular mortality in the total study sample (n = 2009) and in a healthy subsample (n = 1885). Desaturase indexes were estimated as product-to-precursor FA ratios. RESULTS: During follow-up, 1012 men in the total sample died and 931 men in the healthy subsample died. Desaturase indexes predicted both total and cardiovascular mortality. The relations were independent of smoking status, physical activity, BMI, total cholesterol, and hypertension. The adjusted and standardized (per SD) hazard ratios (HRs) and 95% CIs for cardiovascular mortality were 1.15 (1.04, 1.27) for stearoyl-CoA-desaturase, 1.12 (1.0, 1.24) for Delta(6)-desaturase, and 0.88 (0.80, 0.98) for Delta(5)-desaturase, respectively. The proportion of serum linoleic acid was inversely related, whereas serum FAs associated with saturated fat intake (palmitic, palmitoleic, and dihomo-gamma-linolenic acids) were directly related to total and cardiovascular mortality. CONCLUSIONS: Altered endogenous FA desaturation might contribute to mortality risk because we observed independent associations between desaturase activity indexes and mortality. The proportion of linoleic acid was inversely related, and FAs reflecting saturated fat intake were directly related to mortality.

  • 258.
    Warren, Helen R.
    et al.
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England..
    Evangelou, Evangelos
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece.;Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece..
    Cabrera, Claudia P.
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England..
    Gao, He
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England..
    Ren, Meixia
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England.;Fujian Med Univ, Fujian Prov Hosp, Dept Cardiol, Fuzhou, Peoples R China..
    Mifsud, Borbala
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England..
    Ntalla, Ioanna
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England..
    Surendran, Praveen
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England..
    Liu, Chunyu
    NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;Boston Univ, Sch Publ Hlth, Boston, MA USA.;NHLBI, Framingham Heart Study, Framingham, MA USA..
    Cook, James P.
    Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England..
    Kraja, Aldi T.
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA.;Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63110 USA..
    Drenos, Fotios
    Univ Bristol, Sch Social & Community Med, MRC Integrat Epidemiol Unit, Bristol, Avon, England.;UCL, Inst Cardiovasc Sci, Ctr Cardiovasc Genet, London, England..
    Loh, Marie
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;ASTAR, Translat Lab Genet Med, Singapore, Singapore..
    Verweij, Niek
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.;Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA..
    Marten, Jonathan
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Karaman, Ibrahim
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Lepe, Marcelo P. Segura
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Bayer Pharma, Berlin, Germany..
    O'Reilly, Paul F.
    Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England..
    Knight, Joanne
    Univ Lancaster, Data Sci Inst, Lancaster, England..
    Snieder, Harold
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Kato, Norihiro
    Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo, Japan..
    He, Jiang
    Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA..
    Tai, E. Shyong
    Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Natl Univ Hlth Syst, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore..
    Said, M. Abdullah
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands..
    Porteous, David
    Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland..
    Alver, Maris
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England..
    Poulter, Neil
    Farrall, Martin
    Univ Oxford, Radcliffe Dept Med, Wellcome Trust Ctr Human Genet, Div Cardiovasc Med, Oxford, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England..
    Gansevoort, Ron T.
    Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, Groningen, Netherlands..
    Padmanabhan, Sandosh
    Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.;Univ Edinburgh, Ctr Genom & Expt Med, Generat Scotland, Edinburgh, Midlothian, Scotland.;Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, British Heart Fdn Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland..
    Magi, Reedik
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England..
    Stanton, Alice
    Royal Coll Surgeons Ireland, Mol & Cellular Therapeut, Dublin, Ireland..
    Connell, John
    Univ Dundee, Ninewells Hosp & Med Sch, Dundee, Scotland..
    Bakker, Stephan J. L.
    Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands..
    Metspalu, Andres
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England..
    Shields, Denis C.
    Univ Coll Dublin, Conway Inst, Sch Med, Dublin, Ireland..
    Thom, Simon
    Imperial Coll London, Natl Heart & Lung Inst, London, England.;Imperial Coll London, Int Ctr Circulatory Hlth, London, England..
    Brown, Morris
    Sever, Peter
    Imperial Coll London, Natl Heart & Lung Inst, London, England..
    Esko, Tonu
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England.;Childrens Hosp, Div Endocrinol, 300 Longwood Ave, Boston, MA 02115 USA.;Broad Inst Harvard & MIT, Cambridge, England..
    Hayward, Caroline
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Genom & Expt Med, Generat Scotland, Edinburgh, Midlothian, Scotland..
    van der Harst, Pim
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands..
    Saleheen, Danish
    Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.;Ctr Noncommun Dis, Karachi, Pakistan.;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Chowdhury, Rajiv
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England..
    Chambers, John C.
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Ealing Hosp Natl Hlth Serv NHS Trust, Southall, Middx, England.;Imperial Coll Healthcare NHS Trust, London, England.;Imperial Coll Healthcare NHS Trust, London, England.;Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore.;Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England..
    Chasman, Daniel I.
    Chakravarti, Aravinda
    Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Baltimore, MD USA..
    Newton-Cheh, Christopher
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Broad Inst Harvard & MIT, Cambridge, England..
    Lindgren, Cecilia M.
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford, England..
    Levy, Daniel
    NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;NHLBI, Framingham Heart Study, Framingham, MA USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA..
    Kooner, Jaspal S.
    Imperial Coll London, Natl Heart & Lung Inst, London, England.;Imperial Coll Healthcare NHS Trust, London, England.;Imperial Coll Healthcare NHS Trust, London, England.;Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England.;Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England.;Imperial Coll London, Cardiovasc Sci, Natl Heart & Lung Inst, Hammersmith Campus, London, England..
    Keavney, Bernard
    Univ Manchester, Fac Biol Med & Hlth, Div Cardiovasc Sci, Manchester, Lancs, England.;Cent Manchester NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Div Med, Manchester, Lancs, England..
    Tomaszewski, Maciej
    Univ Manchester, Fac Biol Med & Hlth, Div Cardiovasc Sci, Manchester, Lancs, England.;Cent Manchester NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Div Med, Manchester, Lancs, England..
    Samani, Nilesh J.
    Howson, Joanna M. M.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England..
    Tobin, Martin D.
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Munroe, Patricia B.
    Ehret, Georg B.
    Wain, Louise V.
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Barnes, Michael R.
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England..
    Tzoulaki, Joanna
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England..
    Caulfield, Mark J.
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England..
    Elliott, Paul
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England..
    Vaez, Ahmad
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommun Dis, Esfahan, Iran..
    Jansen, Rick
    Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Neurosci Campus Amsterdam, Amsterdam, Netherlands..
    Joehanes, Roby
    NHLBI, Framingham Heart Study, Framingham, MA USA.;Harvard Med Sch, Hebrew SeniorLife, Boston, MA USA..
    van der Most, Peter J.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Erzurumluoglu, A. Mesut
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    O'Reilly, Paul
    Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England..
    Rose, Lynda M.
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA..
    Verwoert, Germaine C.
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
    Hottenga, Jouke-Jan
    Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands..
    Strawbridge, Rona J.
    Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ Sjukhuset, Ctr Mol Med, Solna, Sweden..
    Arking, Dan E.
    Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Baltimore, MD USA..
    Hwang, Shih-Jen
    NHLBI, Populat Sci Branch, US NIH, Bldg 10, Bethesda, MD 20892 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA..
    Guo, Xiuqing
    Harbor UCLA Med Ctr, LABioMed, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA..
    Kutalik, Zoltan
    Univ Lausanne Hosp, Inst Social & Prevent Med, Lausanne, Switzerland.;Swiss Inst Bioinformat, Lausanne, Switzerland..
    Trompet, Stella
    Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands..
    Shrine, Nick
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Teumer, Alexander
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Greifswald, Germany..
    Ried, Janina S.
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany..
    Bis, Joshua C.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA..
    Smith, Albert V.
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Amin, Najaf
    Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands..
    Nolte, Ilja M.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Lyytikainen, Leo-Pekka
    Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Univ Tampere, Sch Med, Dept Clin Chem, Tampere, Finland..
    Mahajan, Anubha
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Wareham, Nicholas J.
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England..
    Hofer, Edith
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria.;Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria..
    Joshi, Peter K.
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Kristiansson, Kati
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Traglia, Michela
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Havulinna, Aki S.
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Goel, Anuj
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England..
    Nalls, Mike A.
    NIA, Neurogenet Lab, US NIH, Bethesda, MD 20892 USA.;Kelly Serv, Rockville, MD USA..
    Sober, Siim
    Univ Tartu, Inst Mol & Cell Biol, Human Mol Genet Res Grp, Tartu, Estonia..
    Vuckovic, Dragana
    Sidra Med & Res Ctr, Expt Genet Div, Doha, Qatar.;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Luan, Jian'an
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England..
    Del Greco M, Fabiola
    European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.;Univ Lubeck, Lubeck, Germany..
    Ayers, Kristin L.
    Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA..
    Marrugat, Jaume
    IMIM, Cardiovasc Epidemiol & Genet, Barcelona, Spain..
    Ruggiero, Daniela
    CNR, Inst Genet & Biophys Buzzati Traverso, Naples, Italy..
    Lopez, Lorna M.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Beaumont Hosp, Educ & Res Ctr, Royal Coll Surg Ireland, Dept Psychiat, Dublin, Ireland.;UCD, Ctr Proteome Res, UCD Conway Inst, Dublin, Ireland..
    Niiranen, Teemu
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Enroth, Stefan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Jackson, Anne U.
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    Nelson, Christopher P.
    Univ Leicester, Glenfield Hosp, BHF Cardiovasc Res Ctr, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England..
    Huffman, Jennifer E.
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Zhang, Weihua
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England..
    Gandin, Ilaria
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Harris, Sarah E.
    Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland..
    Zemonik, Tatijana
    Univ Split, Fac Med, Dept Biol, Split, Croatia..
    Lu, Yingchang
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA..
    Shah, Nabi
    Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee, Scotland.;COMSATS Inst Informat Technol, Dept Pharm, Abbottabad, Pakistan..
    de Borst, Martin H.
    Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands..
    Mangino, Massimo
    Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.;Natl Inst Hlth Res, Biomed Res Ctr, London, England..
    Prins, Bram P.
    Wellcome Trust Sanger Inst, Dept Human Genet, Cambridge, England..
    Campbell, Archie
    Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Genom & Expt Med, Generat Scotland, Edinburgh, Midlothian, Scotland..
    Li-Gao, Ruifang
    Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands..
    Chauhan, Ganesh
    Bordeaux Populat Hlth Ctr, INSERM, U1219, Bordeaux, France.;Bordeaux Univ, Bordeaux, France..
    Oldmeadow, Christopher
    Hunter Med Res Inst, New Lambton, NSW, Australia..
    Abecasis, Goncalo
    SPH II, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI USA..
    Abedi, Maryam
    Isfahan Univ Med Sci, Dept Genet & Mol Biol, Esfahan, Iran..
    Barbieri, Caterina M.
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Batini, Chiara
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Blake, Tineka
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Boehnke, Michael
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    Bottinger, Erwin P.
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA..
    Braund, Peter S.
    Univ Leicester, Glenfield Hosp, BHF Cardiovasc Res Ctr, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England..
    Brumat, Marco
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Campbell, Harry
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Cocca, Massimiliano
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Collins, Francis
    NHGRI, Med Genom & Metab Genet Branch, US NIH, Bethesda, MD 20892 USA..
    Cordell, Heather J.
    Newcastle Univ, Inst Med Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England..
    Damman, Jeffrey J.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands..
    Davies, Gail
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    de Geus, Eco J.
    Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands..
    de Mutsert, Renee
    Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands..
    Deelen, Joris
    Leiden Univ, Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands..
    Demirkale, Yusuf
    US NIH, Ctr Informat Technol, Bethesda, MD USA..
    Doney, Alex S. F.
    Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee, Scotland..
    Dorr, Marcus
    DZHK German Ctr Cardiovasc Res, Greifswald, Germany.;Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany..
    Ferreira, Teresa
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Franberg, Mattias
    Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ Sjukhuset, Ctr Mol Med, Solna, Sweden.;Stockholm Univ, Dept Numer Anal & Comp Sci, Stockholm, Sweden..
    Giedraitis, Vilmantas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Gieger, Christian
    Helmholtz Zentrum Munchen, Deutsch Forsch Zentrum Gesundheit & Umwelt, Neuherberg, Germany..
    Giulianini, Franco
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA..
    Gow, Alan J.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Heriot Watt Univ, Sch Life Sci, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Hamsten, Anders
    Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ Sjukhuset, Ctr Mol Med, Solna, Sweden..
    Harris, Tamara B.
    NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA..
    Hofman, Albert
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA..
    Holliday, Elizabeth G.
    Hunter Med Res Inst, New Lambton, NSW, Australia..
    Jarvelin, Marjo-Riitta
    Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England.;Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland.;Univ Oulu, Bioctr Oulu, Oulu, Finland.;Oulu Univ Hosp, Unit Primary Care, Oulu, Finland..
    Johansson, Åsa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Johnson, Andrew D.
    NHLBI, Framingham Heart Study, Framingham, MA USA.;NHLBI, Cardiovasc Epidemiol & Human Genom Branch, Bldg 10, Bethesda, MD 20892 USA..
    Jousilahti, Pekka
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Jula, Antti
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Kahonen, Mika
    Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Univ Tampere, Sch Med, Dept Clin Physiol, Tampere, Finland..
    Kathiresan, Sekar
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA..
    Khaw, Kay-Tee
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Kolcic, Ivana
    Univ Split, Fac Med, Dept Publ Hlth, Split, Croatia..
    Koskinen, Seppo
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Langenberg, Claudia
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England..
    Larson, Marty
    NHLBI, Framingham Heart Study, Framingham, MA USA..
    Launer, Lenore J.
    NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA..
    Lehne, Benjamin
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Liewald, David C. M.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Lin, Li
    Univ Hosp Geneva, Dept Med, Cardiol, Geneva, Switzerland..
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Mach, Francois
    Univ Hosp Geneva, Dept Med, Cardiol, Geneva, Switzerland..
    Mamasoula, Chrysovalanto
    Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne, Tyne & Wear, England..
    Menni, Cristina
    Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England..
    Milaneschi, Yuri
    Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Psychiat, Amsterdam, Netherlands..
    Morgan, Anna
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Morris, Andrew D.
    Univ Edinburgh, Sch Med, Sch Mol Genet & Populat Hlth Sci, Edinburgh, Midlothian, Scotland..
    Morrison, Alanna C.
    Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA..
    Munson, Peter J.
    US NIH, Ctr Informat Technol, Bethesda, MD USA..
    Nandakumar, Priyanka
    Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Baltimore, MD USA..
    Nguyen, Quang Tri
    Nutile, Teresa
    CNR, Inst Genet & Biophys Buzzati Traverso, Naples, Italy..
    Oldehinkel, Albertine J.
    Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands..
    Oostra, Ben A.
    Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands..
    Org, Elin
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England..
    Palotie, Aarno
    Univ Helsinki, FIMM, Helsinki, Finland..
    Pare, Guillaume
    McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada..
    Pattie, Alison
    Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Penninx, Brenda W. J. H.
    Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Psychiat, Amsterdam, Netherlands..
    Pramstaller, Peter P.
    European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.;Univ Lubeck, Lubeck, Germany.;Gen Cent Hosp, Dept Neurol, Bolzano, Italy.;Univ Lubeck, Dept Neurol, Lubeck, Germany..
    Raitakari, Olli T.
    Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland..
    Rice, Kenneth
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA..
    Ridker, Paul M.
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA..
    Riese, Harriette
    Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands..
    Ripatti, Samuli
    Univ Helsinki, FIMM, Helsinki, Finland..
    Robino, Antonietta
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy..
    Rotter, Jerome I.
    Harbor UCLA Med Ctr, LABioMed, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.;Harbor UCLA Med Ctr, LABioMed, Dept Med, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA..
    Rudan, Igor
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Saba, Yasaman
    Med Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, Graz, Austria..
    Saint Pierre, Aude
    European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.;Univ Lubeck, Lubeck, Germany.;Etab Francais Sang, INSERM, U1078, Brest, France..
    Sala, Cinzia F.
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Sarin, Antti-Pekka
    Univ Helsinki, FIMM, Helsinki, Finland..
    Schmidt, Reinhold
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria..
    Scott, Rodney
    Hunter Med Res Inst, New Lambton, NSW, Australia.;Univ Newcastle, Fac Hlth, Callaghan, NSW, Australia.;John Hunter Hosp, Sch Biomed Sci & Pharm, New Lambton, NSW, Australia..
    Seelen, Marc A.
    Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands..
    Siscovick, David
    New York Acad Med, New York, NY USA..
    Sorice, Rossella
    CNR, Inst Genet & Biophys Buzzati Traverso, Naples, Italy.;IRCCS Neuromed, Pozzilli, Italy..
    Stott, David J.
    Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland..
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Swertz, Morris
    Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands..
    Taylor, Kent D.
    Harbor UCLA Med Ctr, Los Angeles BioMed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.;Harbor UCLA Med Ctr, Dept Pediat, Div Genet Outcomes, Torrance, CA 90509 USA..
    Tzoulaki, Ioanna
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Tzourio, Christophe
    Bordeaux Populat Hlth Ctr, INSERM, U1219, Bordeaux, France.;Bordeaux Univ, Bordeaux, France.;Bordeaux Univ Hosp, Dept Publ Hlth, Bordeaux, France..
    Uitterlinden, Andre G.
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands..
    Volker, Uwe
    DZHK German Ctr Cardiovasc Res, Greifswald, Germany.;Univ Med Greifswald, Interfac Inst Genet & Funct Gen, Greifswald, Germany..
    Vollenweider, Peter
    CHU Vaudois, Univ Lausanne Hosp, Dept Internal Med, Lausanne, Switzerland..
    Wild, Sarah
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Willemsen, Gonneke
    Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands..
    Wright, Alan F.
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Yao, Jie
    Harbor UCLA Med Ctr, LABioMed, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA..
    Theriault, Sebastien
    McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada..
    Conen, David
    McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada..
    John, Attia
    Hunter Med Res Inst, New Lambton, NSW, Australia.;Univ Newcastle, Fac Hlth, Callaghan, NSW, Australia.;John Hunter Hosp, Sch Biomed Sci & Pharm, New Lambton, NSW, Australia..
    Debette, Stephanie
    Bordeaux Populat Hlth Ctr, INSERM, U1219, Bordeaux, France.;Bordeaux Univ, Bordeaux, France.;Bordeaux Univ Hosp, Dept Neurol, Bordeaux, France..
    Mook-Kanamori, Dennis O.
    Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands..
    Zeggini, Eleftheria
    Wellcome Trust Sanger Inst, Dept Human Genet, Cambridge, England..
    Spector, Tim D.
    Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England..
    Palmer, Colin N. A.
    Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee, Scotland..
    Vergnaud, Anne-Claire
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Loos, Ruth J. F.
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria.;Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth Dev Inst, New York, NY 10029 USA..
    Polasek, Ozren
    Univ Split, Fac Med, Dept Publ Hlth, Split, Croatia..
    Starr, John M.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh, Midlothian, Scotland..
    Girotto, Giorgia
    Sidra Med & Res Ctr, Expt Genet Div, Doha, Qatar.;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Lindgren, Cecila M.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Broad Inst Harvard & MIT, Cambridge, England..
    Vitart, Veronique
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Tuomilehto, Jaakko
    Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland.;South Ostrobothnia Cent Hosp, Seinajoki, Finland.;Hosp Univ La Paz, Red RECAVA Grp RD06 0014 0015, Madrid, Spain.;Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria..
    Gyllensten, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Knekt, Paul
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Deary, Ian J.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Ciullo, Marina
    CNR, Inst Genet & Biophys Buzzati Traverso, Naples, Italy.;IRCCS Neuromed, Pozzilli, Italy..
    Elosua, Roberto
    IMIM, Cardiovasc Epidemiol & Genet, Barcelona, Spain..
    Keavney, Bernard D.
    Univ Manchester, Fac Biol Med & Hlth, Div Cardiovasc Sci, Manchester, Lancs, England..
    Hicks, Andrew A.
    European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.;Univ Lubeck, Lubeck, Germany..
    Scott, Robert A.
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England..
    Gasparini, Paolo
    Sidra Med & Res Ctr, Expt Genet Div, Doha, Qatar.;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Laan, Maris
    Univ Tartu, Inst Mol & Cell Biol, Human Mol Genet Res Grp, Tartu, Estonia.;Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia..
    Liu, YongMei
    Wake Forest Sch Med, Div Publ Hlth Sci, Winston Salem, NC USA..
    Watkins, Hugh
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England..
    Hartman, Catharina A.
    Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands..
    Salomaa, Veikko
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Toniolo, Daniela
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Perola, Markus
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.;Univ Helsinki, FIMM, Helsinki, Finland.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia..
    Wilson, James F.
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Schmidt, Helena
    Med Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, Graz, Austria.;Med Univ Graz, Dept Neurol, Graz, Austria..
    Zhao, Jing Hua
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England..
    Lehtimaki, Terho
    Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Univ Tampere, Sch Med, Dept Clin Chem, Tampere, Finland..
    van Duijn, Cornelia M.
    Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands..
    Gudnason, Vilmundur
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Psaty, Bruce M.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.;Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA.;Grp Hlth, Grp Hlth Res Inst, Seattle, WA USA..
    Peters, Annette
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany..
    Rettig, Rainer
    Univ Med Greifswald, Inst Physiol, Karlsburg, Germany..
    James, Alan
    Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep, Nedlands, WA, Australia.;Univ Western Australia, Sch Med & Pharmacol, Crawley, WA, Australia..
    Jukema, J. Wouter
    Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands..
    Strachan, David P.
    St Georges Univ London, Populat Hlth Res Inst, London, England..
    Palmas, Walter
    Columbia Univ, Med Ctr, Dept Med, New York, NY USA..
    Ingelsson, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA..
    Boomsma, Dorret I.
    Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands..
    Franco, Oscar H.
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
    Bochud, Murielle
    Univ Lausanne Hosp, Inst Social & Prevent Med, Lausanne, Switzerland..
    Morris, Andrew P.
    Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk2017Inngår i: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 49, nr 3, s. 403-415Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.

  • 259. Westerlund, Anna
    et al.
    Bellocco, Rino
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Adami, Hans-Olov
    Åkerstedt, Torbjörn
    Trolle Lagerros, Ylva
    Sleep characteristics and cardiovascular events in a large Swedish cohort2013Inngår i: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 28, nr 6, s. 463-473Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Limited evidence suggests that the association between sleep duration and cardiovascular events is strongest in individuals who also report sleep disturbances. We investigated sleep duration and insomnia symptoms in relation to incident cardiovascular events in the Swedish National March Cohort comprising 41,192 adults. Habitual sleep duration and difficulty falling asleep, difficulty maintaining sleep, early morning awakening, and nonrestorative sleep were self-reported in 1997. During 13.2 years of follow-up, we identified 4,031 events (myocardial infarction, stroke, heart failure, or death from cardiovascular disease) in the Swedish National Patient Register and the Cause of Death Register. After adjustment for potential confounders, short sleep duration (a parts per thousand currency sign5 h) was associated with slightly increased risks of overall cardiovascular events and, specifically, myocardial infarction: hazard ratio, HR (95 % confidence interval) 1.24 (1.06-1.44) and 1.42 (1.15-1.76), respectively. These HRs were attenuated as we included BMI, depressive symptoms and other relevant covariates in our analysis. Insomnia symptoms per se were unrelated to risk. However, in a joint analysis, there was some evidence that short sleepers who reported frequent insomnia symptoms had the highest HRs (1.26-1.39) of overall cardiovascular events. Short sleep or insomnia symptoms without the other conferred no increased risk. Our results suggest that symptoms of sleep disturbance should be taken into account when assessing the association between short sleep and cardiovascular disease.

  • 260.
    Wiberg, Bernice
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Kilander, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Byberg, Liisa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Cognitive Function Prior to Stroke is a Risk Factor for Post-Stroke Mortality but Not DependencyArtikkel i tidsskrift (Annet vitenskapelig)
  • 261.
    Wiberg, Bernice
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Kilander, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Byberg, Liisa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Ortopedi.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    The relationship between executive dysfunction and post-stroke mortality: a population-based cohort study2012Inngår i: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 2, nr 3, s. e000458-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES:

    To study the associations of pre-stroke cognitive performance with mortality after first-ever stroke or transient ischaemic attack (TIA).

    DESIGN:

    A prospective cohort study.

    SETTING AND PARTICIPANTS:

    In participants having first-ever stroke or TIA during up to 14 years of post-test follow-up (n=155), we investigated the associations of pre-stroke variables and cognitive test results with post-stroke survival. The study is based on those participants of the Uppsala Longitudinal Study of Adult Men who performed cognitive function tests at approximately age 70 (n=919).

    PRIMARY OUTCOME MEASURES:

    Mortality after first-ever stroke or TIA related to pre-stroke executive performance.

    RESULTS:

    Eighty-four (54%) of the first-ever stroke/TIA patients died under a median follow-up of 2.5 years after the event. In Cox proportional hazard analyses adjusting for age, education, social group and traditional stroke risk factors, poor performance in Trail Making Test (TMT)-A was related to mortality (HR 1.88 per SD, 95% CI 1.31 to 2.71, p=0.001). The risk of mortality was approximately threefold higher in the highest tertile compared with the lowest tertile (HR TMT-A= 2.90 per SD, 95% CI 1.24 to 6.77, p=0.014). A similar pattern was seen for TMT-B, but Mini-Mental State Examination results were not related to risk of post-stroke mortality.

    CONCLUSION:

    Executive performance measured by TMT-A and -B before stroke was independently associated with long-term risk of mortality, after first-ever stroke or TIA in a population-based study of older men.

  • 262.
    Wiberg, Bernice
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Kilander, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Zethelius, Björn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Sundelöf, Johan E
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Cognitive function and risk of stroke in elderly men2010Inngår i: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 74, nr 5, s. 379-385Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: Vascular risk factors are associated with ischemic changes in the cerebral white matter. We studied the predictive value of cognitive test performance especially related to subcortico-frontal pathways, together with a cognitive screening test, for later incidence of fatal or nonfatal stroke or TIAs and stroke subtypes. METHODS: A sample of 930 70-year-old men without previous stroke/TIA from the community-based Uppsala Longitudinal Study of Adult Men was investigated at baseline using Trail Making Tests (TMT) A and B and the Mini-Mental State Examination (MMSE). RESULTS: During up to 13 years of follow-up, 166 men developed a stroke or TIA; 105 participants had a brain infarction. In Cox proportional hazards analyses adjusting for education, social group, and traditional cardiovascular risk factors, a 1-SD increase in TMT-B time was associated with a higher risk for brain infarction (hazard ratio 1.48, 95% confidence interval 1.11-1.97). The risk of brain infarction was more than threefold higher in the highest (TMT-B = 146-240 s) compared to the lowest (TMT-B = 43-84 s) TMT-B quartile. TMT-A and MMSE results were not consistently related to stroke outcomes. CONCLUSION: Impaired performance in elderly men measured by Trail Making Test B, a cognitive test especially reflecting subcortico-frontal activities, was an independent predictor of subsequent brain infarction in this community-based sample of elderly men. Our results extend previous findings of cognitive decline as an independent predictor of stroke and indicate that the risk of brain infarction is increased already in the subclinical phase of cognitive deficit.

  • 263.
    Wiberg, Bernice
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Ärnlöv, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Terént, Andreas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Vessby, Bengt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Zethelius, Björn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Metabolic risk factors for stroke and transient ischemic attacks in middle-aged men: a community-based study with long-term follow-up2006Inngår i: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 37, nr 12, s. 2898-2903Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND AND PURPOSE: The impact of lipometabolic and glucometabolic disturbances on stroke incidence remains to be characterized in detail. We investigated relations of a comprehensive panel of baseline lipometabolic and glucometabolic variables to incident fatal and nonfatal stroke or transient ischemic attack (TIA), and stroke subtypes. METHODS: A community-based prospective study of 2313 middle-aged men invited to a health survey at age 50. RESULTS: During a follow-up of up to 32 years, 421 developed stroke or TIA. In Cox proportional hazards analyses adjusting for treatment with cardiovascular drugs at baseline, 1-standard deviation increases in body mass index, systolic and diastolic blood pressures, serum proinsulin, and lipoprotein(a) were associated with 11 to 35% increased risk for subsequent stroke/TIA. Electrocardiographic left ventricular hypertrophy and smoking were also associated with a higher risk for stroke/TIA. Essentially the same variables were related to brain infarction/TIA. Higher proportions of palmitic (16:0), palmitoleic (16:1), and oleic acid (18:1) in cholesterol esters were associated with an increased risk, whereas a higher proportion of linoleic acid (18:2 n-6) was protective against stroke/TIA. Further adjusting all models also for hypertension, diabetes, the metabolic syndrome, serum cholesterol, atrial fibrillation, cardiovascular disease, smoking, and physical activity, essentially the same pattern was observed. CONCLUSIONS: Indices of an unhealthy dietary fat intake and a high serum lipoprotein (a) level predicted fatal and nonfatal stroke/TIA independently of established risk factors in a community-based sample of middle-aged men followed for 32 years.

  • 264.
    Wild, Philipp S.
    et al.
    Prevent Cardiol & Prevent Med, Dept Med 2, Beijing, Peoples R China.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Mainz, Germany.;DZHK German Ctr Cardiovasc Res Partner Site Rhine, Mainz, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol, Langen beckstr 1, D-55131 Mainz, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Langen beckstr 1, D-55131 Mainz, Germany..
    Felix, Janine F.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Room Na 2906,POB 2040, NL-3000 CA Rotterdam, Netherlands..
    Schillert, Arne
    Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany.;DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany..
    Teumer, Alexander
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK Partner Site Greifswald, Greifswald, Germany..
    Chen, Ming-Huei
    Boston Univ, Sch Med, Dept Neurol, Boston, MA 02215 USA..
    Leening, Maarten J. G.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Cardiol, Erasmus MC, Rotterdam, Netherlands..
    Voelker, Uwe
    DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany..
    Grossmann, Vera
    Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Mainz, Germany..
    Brody, Jennifer A.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA..
    Irvin, Marguerite R.
    Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA..
    Shah, Sanjiv J.
    Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA..
    Pramana, Setia
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Lieb, Wolfgang
    Christian Albrechts Univ Kiel, Inst Epidemiol & Popgen Biobank, Kiel, Germany..
    Schmidt, Reinhold
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria..
    Stanton, Alice V.
    Beaumont Hosp, Blood Pressure Unit, Dublin, Ireland.;Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin, Ireland..
    Malzahn, Doerthe
    Georg August Univ, Univ Med Ctr, Dept Genet Epidemiol, Gottingen, Germany..
    Smith, Albert Vernon
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Minelli, Cosetta
    Imperial Coll London, Natl Heart & Lung Inst NHLI, Populat Hlth & Occupat Dis, London, England..
    Ruggiero, Daniela
    Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy..
    Lyytikainen, Leo-Pekka
    Dept Clin Chem, Fimlab Labs, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Tampere, Finland..
    Tiller, Daniel
    Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol, Biostat & Informat, Halle, Germany..
    Smith, J. Gustav
    Lund Univ, Dept Cardiol, Lund, Sweden.;Skane Univ Hosp, Lund, Sweden.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA USA..
    Monnereau, Claire
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Generat R Study Grp, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Pediat, Erasmus MC, Rotterdam, Netherlands..
    Di Tullio, Marco R.
    Columbia Univ, Med Ctr, Dept Med, New York, NY USA..
    Musani, Solomon K.
    Univ Mississippi, Med Ctr, Jackson Heart Study, Jackson, MS 39216 USA..
    Morrison, Alanna C.
    Univ Texas Hlth Sci Ctr Houston, Dept Epidemiol, Human Genet & Environm Sci, Houston, TX USA..
    Pers, Tune H.
    Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.;Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark..
    Morley, Michael
    Univ Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Div Cardiovasc Med, Philadelphia, PA 19104 USA..
    Kleber, Marcus E.
    Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany..
    Aragam, Jayashri
    Harvard Med Sch, Boston, MA USA.;Vet Adm Hosp, West Roxbury, Boston, MA USA..
    Benjamin, Emelia J.
    Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Boston Univ, Sch Med & Publ Hlth, Sect Cardiol, Prevent Med & Epidemiol, Boston, MA USA..
    Bis, Joshua C.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA..
    Bisping, Egbert
    Med Univ Graz, Dept Cariol, Graz, Austria..
    Broeckel, Ulrich
    Med Coll Wisconsin, Milwaukee, WI 53226 USA..
    Cheng, Susan
    Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA USA..
    Deckers, Jaap W.
    Univ Med Ctr Rotterdam, Dept Cardiol, Erasmus MC, Rotterdam, Netherlands..
    Del Greco, Fabiola
    Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany..
    Edelmann, Frank
    Charite Univ Med Berlin, Dept Cardiol, Campus Virchow Klinikum, Berlin, Germany..
    Fornage, Myriam
    Univ Texas Hlth Sci Ctr, Houston, TX USA..
    Franke, Lude
    Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands..
    Friedrich, Nele
    DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Inst Clin Chem, Greifswald, Germany.;Univ Med Greifswald, Lab Med, Greifswald, Germany..
    Harris, Tamara B.
    Natl Inst Aging, NIH, Lab Epidemiol Demog & Biometry, Bethesda, MD USA..
    Hofer, Edith
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria.;Med Univ Graz, Inst Med Informat, Stat & Documentat, Graz, Austria..
    Hofman, Albert
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands..
    Huang, Jie
    Boston VA Res Inst, Boston, MA USA.;Harvard Med Sch, Brigham & Womens Hosp, Div Aging, Boston, MA USA..
    Hughes, Alun D.
    UCL, Inst Cardiovasc Sci, London, England..
    Kahonen, Mika
    Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Physiol, Tampere, Finland..
    Kruppa, Jochen
    Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany.;Univ Vet Med, Fdn Inst Vet Med & Genet, Hannover, Germany..
    Lackner, Karl J.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik. Univ Med Ctr Mainz, Inst Clin Chem & Lab Med, Mainz, Germany.
    Lannfelt, Lars
    Univ Med Ctr Mainz, Dept Med 2, Mainz, Germany..
    Laskowski, Rafael
    Univ Med Ctr Mainz, Dept Med 2, Mainz, Germany..
    Launer, Lenore J.
    Natl Inst Aging, NIH, Neuroepidemiol Sect, Bethesda, MD USA..
    Leosdottir, Margret
    Lund Univ, Dept Cardiol, Lund, Sweden.;Skane Univ Hosp, Malmo, Sweden..
    Lin, Honghuang
    Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Boston Univ, Sch Med, Dept Med, Sect Computat Biomed, Boston, MA 02215 USA..
    Lindgren, Cecilia M.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Univ, Cambridge, MA 02138 USA..
    Loley, Christina
    Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany..
    MacRae, Calum A.
    MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Univ, Cambridge, MA 02138 USA.;Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA..
    Mascalzoni, Deborah
    Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany..
    Mayet, Jamil
    Hammersmith Hosp, Int Ctr Circulatory Hlth, London, England.;NHLI, Imperial Coll London, London, England..
    Medenwald, Daniel
    Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol, Biostat & Informat, Halle, Germany..
    Morris, Andrew P.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England..
    Mueller, Christian
    Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany..
    Mueller-Nurasyid, Martina
    Ludwig Maximilians Univ Munchen, Dept Med 1, Munich, Germany.;DZHK Partner Site Munich Heart Alliance, Munich, Germany.;Inst Genet Epidemiol, Helmholtz Zentrum Munchen German Res Ctr Environm, Neuherberg, Germany..
    Nappo, Stefania
    Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy..
    Nilsson, Peter M.
    Lund Univ, Dept Clin Sci, Malmo, Sweden.;Skane Univ Hosp, Dept Internal Med, Malmo, Sweden..
    Nuding, Sebastian
    Univ Clin Halle Saale, Martin Luther Univ Halle Wittenberg, Dept Med 3, Halle, Germany..
    Nutile, Teresa
    Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy..
    Peters, Annette
    DZHK Partner Site Munich Heart Alliance, Munich, Germany.;Inst Epidemiol II, Helmholtz Zentrum Munchen German Res Ctr Environm, Neuherberg, Germany..
    Pfeufer, Arne
    Inst Human Genet, Helmholtz Zentrum Munchen, Neuherberg, Germany..
    Pietzner, Diana
    Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol, Biostat & Informat, Halle, Germany..
    Pramstaller, Peter P.
    Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany.;Gen Cent Hosp, Dept Neurol, Bolzano, Italy.;Univ Lubeck, Dept Neurol, Lubeck, Germany..
    Raitakari, Olli T.
    Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland..
    Rice, Kenneth M.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA..
    Rivadeneira, Fernando
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Generat R Study Grp, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands..
    Rotter, Jerome I.
    Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA USA.;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA USA..
    Ruohonen, Saku T.
    Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland..
    Sacco, Ralph L.
    Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL USA.;Univ Miami, Miller Sch Med, McKnight Brain Inst Miller, Miami, FL USA.;Univ Miami, Dept Publ Hlth Sci, Miami, FL USA.;Univ Miami, Dept Human Gen, Miami, FL USA..
    Samdarshi, Tandaw E.
    Univ Mississippi, Med Ctr, Div Cardiol, Jackson, MS 39216 USA..
    Schmidt, Helena
    Med Univ Graz, Inst Mol Biol & Biochem, Graz, Austria..
    Sharp, Andrew S. P.
    Royal Devon & Exeter Hosp & Univ Exeter, Dept Cardiol, Exeter, Devon, England..
    Shields, Denis C.
    Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Dublin, Ireland.;Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland..
    Sorice, Rossella
    Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy.;IRCCS Neuromed, Pozzilli, Isernia, Italy..
    Sotoodehnia, Nona
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Div Cardiol, Seattle, WA 98195 USA..
    Stricker, Bruno H.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands.;Inspectorate Hlth Care, Utrecht, Netherlands..
    Surendran, Praveen
    Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin, Ireland.;Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland..
    Thom, Simon
    Hammersmith Hosp, Int Ctr Circulatory Hlth, London, England.;NHLI, Imperial Coll London, London, England..
    Toeglhofer, Anna M.
    Med Univ Graz, Inst Mol Biol & Biochem, Graz, Austria..
    Uitterlinden, Andre G.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands..
    Wachter, Rolf
    Georg August Univ, Univ Med Ctr Gottingen, Dept Cardiol & Pneumol, Gottingen, Germany..
    Voelzke, Henry
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK Partner Site Greifswald, Greifswald, Germany..
    Ziegler, Andreas
    Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany.;DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany.;Univ KwaZulu Natal, Sch Math, Stat & Comp Sci, Durban, South Africa.;Univ Lubeck, Zentrum Klin Studien, Lubeck, Germany..
    Muenzel, Thomas
    DZHK German Ctr Cardiovasc Res Partner Site Rhine, Mainz, Germany.;Univ Med Ctr Mainz, Dept Med 2, Mainz, Germany..
    Maerz, Winfried
    Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany.;Synlab Acad, Synlab Serv GmbH, Mannheim, Germany.;Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria..
    Cappola, Thomas P.
    Univ Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Div Cardiovasc Med, Philadelphia, PA 19104 USA..
    Hirschhorn, Joel N.
    Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Harvard Med Sch, Dept Genet, Boston, MA USA..
    Mitchell, Gary F.
    Cardiovasc Engn Inc, Norwood, MA USA..
    Smith, Nicholas L.
    Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.;Grp Hlth Res Inst, Grp Hlth Cooperat, Seattle, WA USA.;Seattle Epidemiol Res & Informat Ctr, Dept Vet Affairs Off Res & Dev, Seattle, WA USA..
    Fox, Ervin R.
    Univ Mississippi, Med Ctr, Div Cardiol, Jackson, MS 39216 USA..
    Dueker, Nicole D.
    Univ Miami, Miller Sch Med, John P Hussman Inst Human Gen, Miami, FL USA..
    Jaddoe, Vincent W. V.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Generat R Study Grp, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Pediat, Erasmus MC, Rotterdam, Netherlands..
    Melander, Olle
    Lund Univ, Dept Clin Sci, Malmo, Sweden.;Skane Univ Hosp, Dept Internal Med, Malmo, Sweden..
    Russ, Martin
    Univ Clin Halle Saale, Martin Luther Univ Halle Wittenberg, Dept Med 3, Halle, Germany.;Helios Amperklin Dachau, Dachau, Germany..
    Lehtimaki, Terho
    Dept Clin Chem, Fimlab Labs, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Tampere, Finland..
    Ciullo, Marina
    Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy.;IRCCS Neuromed, Pozzilli, Isernia, Italy..
    Hicks, Andrew A.
    Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany..
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Gudnason, Vilmundur
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Pieske, Burkert
    Med Univ Graz, Dept Cariol, Graz, Austria.;Charite Univ Med Berlin, Dept Cardiol, Campus Virchow Klinikum, Berlin, Germany.;German Heart Inst Berlin DHZB, Dept Internal Med Cardiol, Berlin, Germany..
    Barron, Anthony J.
    Hammersmith Hosp, Int Ctr Circulatory Hlth, London, England.;NHLI, Imperial Coll London, London, England..
    Zweiker, Robert
    Med Univ Graz, Dept Cariol, Graz, Austria..
    Schunkert, Heribert
    DZHK Partner Site Munich Heart Alliance, Munich, Germany.;Tech Univ Munich, Deutsches Herzzentrum, Munich, Germany..
    Ingelsson, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA..
    Liu, Kiang
    Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA..
    Arnett, Donna K.
    Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA..
    Psaty, Bruce M.
    Grp Hlth Res Inst, Grp Hlth Cooperat, Seattle, WA USA.;Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Epidemiol & Hlth Serv, Seattle, WA 98195 USA..
    Blankenberg, Stefan
    DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany.;Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany..
    Larson, Martin G.
    Boston Univ, Sch Publ Hlth, Biostat Dept, Boston, MA 02215 USA.;Boston Univ, Dept Math & Stat, Boston, MA USA..
    Felix, Stephan B.
    DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Dept Internal Med B, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany..
    Franco, Oscar H.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands..
    Zeller, Tanja
    DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany.;Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany..
    Vasan, Ramachandran S.
    Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Boston Univ, Sch Med & Publ Hlth, Sect Cardiol, Prevent Med & Epidemiol, Boston, MA USA.;Boston Univ, Sch Med & Framingham Heart Study, Dept Med, Sect Prevent Med & Epidemiol & Cardiol, 801 Massachusetts Ave,Suite 470, Boston, MA 02118 USA..
    Doerr, Marcus
    DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Dept Internal Med B, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany..
    Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function2017Inngår i: Journal of Clinical Investigation, ISSN 0021-9738, E-ISSN 1558-8238, Vol. 127, nr 5, s. 1798-1812Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND. Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS. A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen consortium). The analysis included 16 traits of left ventricular (LV) structure, and systolic and diastolic function. RESULTS. The discovery analysis included 21 cohorts for structural and systolic function traits (n = 32,212) and 17 cohorts for diastolic function traits (n = 21,852). Replication was performed in 5 cohorts (n = 14,321) and 6 cohorts (n = 16,308), respectively. Besides 5 previously reported loci, the combined meta-analysis identified 10 additional genome-wide significant SNPs: rs12541595 near MTSS1 and rs10774625 in ATXN2 for LV end-diastolic internal dimension; rs806322 near KCNRG, rs4765663 in CACNA1C, rs6702619 near PALMD, rs7127129 in TMEM16A, rs11207426 near FGGY, rs17608766 in GOSR2, and rs17696696 in CFDP1 for aortic root diameter; and rs12440869 in IQCH for Doppler transmitral A-wave peak velocity. Findings were in part validated in other cohorts and in GWAS of related disease traits. The genetic loci showed associations with putative signaling pathways, and with gene expression in whole blood, monocytes, and myocardial tissue. CONCLUSION. The additional genetic loci identified in this large meta-analysis of cardiac structure and function provide insights into the underlying genetic architecture of cardiac structure and warrant follow-up in future functional studies.

  • 265.
    Wohlin, Martin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Sundstrom, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Andren, Bertil
    Rönn, Monika
    Larsson, Anders
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    An echolucent carotid artery intima-media is a new and independent predictor of mortalityManuskript (Annet vitenskapelig)
  • 266.
    Wohlin, Martin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Andrén, Bertil
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    An echolucent carotid artery intima-media complex is a new and independent predictor of mortality in an elderly male cohort2009Inngår i: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 205, nr 2, s. 486-491Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The echogenicity of atherosclerotic plaques is a measure of their lipid content and predicts cardiovascular disease. We hypothesized that the echogenicity of the non-plaque-affected arterial wall may be prognostically important as well, and more easily used as not all subjects carry plaques. We investigated the prognostic value of intima-media (IM) echogenicity (measured as the grey scale median [GSM]) for mortality compared with intima-media thickness (IMT) in a population-based sample of elderly men. METHODS: A cohort from a community-based sample of 491 men was investigated with carotid artery ultrasound at age 75. IMT and GSM for IM and plaques were measured in the far wall of the common carotid artery being apparently free of plaque. Cox proportional hazard analysis models were used to investigate linear and non-linear relations of IM-GSM to mortality, adjusted for IMT, body mass index, cholesterol, HDL-cholesterol, triglycerides, systolic blood pressure, antihypertensive treatment, CRP, diabetes, current smoking, pack years of smoking, and previous cardiovascular disease. RESULTS: Seventy-seven subjects died during a median follow-up time of 5.1 years. Participants were divided in tertiles by IM-GSM. In unadjusted analysis, IM-GSM predicted mortality in a U-shaped manner. In Cox proportional hazard analyses, an echolucent IM-GSM was a predictor of all-cause mortality (HR: 3.23; CI: 1.60-6.54; p<0.05) and CVD mortality (n=30, HR: 8.29; CI: 2.03-33.92; p<0.05) independently of IMT and established risk factors. These associations were still significant following adjustment for plaque occurrence and plaque echogenicity. CONCLUSION: An echolucent intima-media complex is a predictor of all-cause and CVD mortality in elderly men independently of plaque occurrence, plaque GSM, IMT and established risk factors, suggesting the echogenicity of the apparently plaque-free intima-media complex provides novel prognostic information regarding mortality after age 75.

  • 267.
    Wohlin, Martin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Lannfelt, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Axelsson, Tomas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Syvänen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Andrén, Bertil
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Basu, Samar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Klinisk nutrition och metabolism.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Apolipoprotein E epsilon 4 genotype is independently associated with increased intima-media thickness in a recessive pattern2007Inngår i: Lipids, ISSN 0024-4201, E-ISSN 1558-9307, Vol. 42, nr 5, s. 451-456Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Polymorphisms in the apolipoprotein E (Apo E) gene have been associated with lipid levels, carotid intima media thickness (CCA-IMT), inflammation and cardiovascular disease (CVD). Earlier findings suggested an association of the Apo E alleles with increased CCA-IMT following a recessive pattern. Whether associations might be independent of C-reactive protein (CRP), lipid levels and other CVD risk factors is not known. We investigated the relationships between Apo E (epsilon2, epsilon3 and epsilon4 alleles) and CCA-IMT, measured by B-mode ultrasound, in dominant and recessive models in a community-based sample of 437 men 75 years of age. In men homozygous for the epsilon4 allele CCA-IMT was significantly increased by 0.13 mm to 0.86 +/- 0.16 mm compared to 0.73 +/- 0.19 mm in non- epsilon4-carriers (P = 0.0012) and 0.73 +/- 0.21 mm in epsilon4 heterozygous (P = 0.0044) in unadjusted recessive models. The association between Apo E epsilon4 genotype and CCA-IMT was independent of Apo E epsilon2 and Apo E epsilon3 alleles, CRP, lipid variables (TG, LDL, HDL) and other CVD risk factors (smoking, hypertension, body mass index, diabetes) (P = 0.018). No relations between Apo E genotype and CCA-IMT were observed in dominant models. No significant associations between the Apo E epsilon2 and epsilon3 alleles and CCA-IMT were found. In this study, men homozygous with the ApoE epsilon4 allele had thicker CCA-IMT, independently of Apo E epsilon2 and epsilon3 alleles, CRP, lipid variables (TG, LDL, HDL) and other CVD risk factors (smoking, hypertension, body mass index, diabetes), suggesting CCA-IMT to be modified by the ApoE epsilon4 genotype in a recessive pattern.

  • 268.
    Wohlin, Martin
    et al.
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Sundström, Johan
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Ärnlöv, Johan
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Andren, Bertil
    Institutionen för medicinska vetenskaper.
    Zethelius, Björn
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Lind, Lars
    Institutionen för medicinska vetenskaper.
    Impaired insulin sensitivity is an independent predictor of common carotid intima-media thickness in a population sample of elderly men.2003Inngår i: Atherosclerosis, ISSN 0021-9150, Vol. 170, nr 1, s. 181-5Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Most previous studies of associations between insulin sensitivity and common carotid artery (CCA) atherosclerosis have been conducted in small samples, have not used direct measurement of insulin sensitivity, and have yielded inconclusive results. We investigated associations of CCA intima-media thickness (IMT) and diameter (CCA-D) measured by B-mode ultrasound and insulin sensitivity measured by the euglycemic hyperinsulinemic clamp test together with risk factors of the insulin resistance syndrome in a community-based sample of 493 elderly men. The clamp glucose disposal rate was an independent predictor of CCA-IMT in multivariate models adjusting for blood pressure, smoking, serum cholesterol, and body mass index (1% decrease in CCA-IMT for a 1 unit increase in glucose disposal rate, P=0.009). Glucose disposal rate was significantly related to CCA-D in univariate (r=-0.11, P=0.02) but not in multivariate models. In conclusion, this study is the first to establish impaired insulin sensitivity, measured by the euglycemic hyperinsulinemic clamp test, as an independent predictor of CCA-IMT in a population-based sample of elderly men.

  • 269. Wood, Andrew R
    et al.
    Esko, Tonu
    Yang, Jian
    Vedantam, Sailaja
    Pers, Tune H
    Gustafsson, Stefan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Chu, Audrey Y
    Estrada, Karol
    Luan, Jian'an
    Kutalik, Zoltán
    Amin, Najaf
    Buchkovich, Martin L
    Croteau-Chonka, Damien C
    Day, Felix R
    Duan, Yanan
    Fall, Tove
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Fehrmann, Rudolf
    Ferreira, Teresa
    Jackson, Anne U
    Karjalainen, Juha
    Lo, Ken Sin
    Locke, Adam E
    Mägi, Reedik
    Mihailov, Evelin
    Porcu, Eleonora
    Randall, Joshua C
    Scherag, André
    Vinkhuyzen, Anna A E
    Westra, Harm-Jan
    Winkler, Thomas W
    Workalemahu, Tsegaselassie
    Zhao, Jing Hua
    Absher, Devin
    Albrecht, Eva
    Anderson, Denise
    Baron, Jeffrey
    Beekman, Marian
    Demirkan, Ayse
    Ehret, Georg B
    Feenstra, Bjarke
    Feitosa, Mary F
    Fischer, Krista
    Fraser, Ross M
    Goel, Anuj
    Gong, Jian
    Justice, Anne E
    Kanoni, Stavroula
    Kleber, Marcus E
    Kristiansson, Kati
    Lim, Unhee
    Lotay, Vaneet
    Lui, Julian C
    Mangino, Massimo
    Leach, Irene Mateo
    Medina-Gomez, Carolina
    Nalls, Michael A
    Nyholt, Dale R
    Palmer, Cameron D
    Pasko, Dorota
    Pechlivanis, Sonali
    Prokopenko, Inga
    Ried, Janina S
    Ripke, Stephan
    Shungin, Dmitry
    Stancáková, Alena
    Strawbridge, Rona J
    Sung, Yun Ju
    Tanaka, Toshiko
    Teumer, Alexander
    Trompet, Stella
    van der Laan, Sander W
    van Setten, Jessica
    Van Vliet-Ostaptchouk, Jana V
    Wang, Zhaoming
    Yengo, Loïc
    Zhang, Weihua
    Afzal, Uzma
    Arnlöv, Johan
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi.
    Arscott, Gillian M
    Bandinelli, Stefania
    Barrett, Amy
    Bellis, Claire
    Bennett, Amanda J
    Berne, Christian
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk diabetologi och metabolism.
    Blüher, Matthias
    Bolton, Jennifer L
    Böttcher, Yvonne
    Boyd, Heather A
    Bruinenberg, Marcel
    Buckley, Brendan M
    Buyske, Steven
    Caspersen, Ida H
    Chines, Peter S
    Clarke, Robert
    Claudi-Boehm, Simone
    Cooper, Matthew
    Daw, E Warwick
    De Jong, Pim A
    Deelen, Joris
    Delgado, Graciela
    Denny, Josh C
    Dhonukshe-Rutten, Rosalie
    Dimitriou, Maria
    Doney, Alex S F
    Dörr, Marcus
    Eklund, Niina
    Eury, Elodie
    Folkersen, Lasse
    Garcia, Melissa E
    Geller, Frank
    Giedraitis, Vilmantas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Go, Alan S
    Grallert, Harald
    Grammer, Tanja B
    Gräßler, Jürgen
    Grönberg, Henrik
    de Groot, Lisette C P G M
    Groves, Christopher J
    Haessler, Jeffrey
    Hall, Per
    Haller, Toomas
    Hallmans, Goran
    Hannemann, Anke
    Hartman, Catharina A
    Hassinen, Maija
    Hayward, Caroline
    Heard-Costa, Nancy L
    Helmer, Quinta
    Hemani, Gibran
    Henders, Anjali K
    Hillege, Hans L
    Hlatky, Mark A
    Hoffmann, Wolfgang
    Hoffmann, Per
    Holmen, Oddgeir
    Houwing-Duistermaat, Jeanine J
    Illig, Thomas
    Isaacs, Aaron
    James, Alan L
    Jeff, Janina
    Johansen, Berit
    Johansson, Åsa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Genomik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Jolley, Jennifer
    Juliusdottir, Thorhildur
    Junttila, Juhani
    Kho, Abel N
    Kinnunen, Leena
    Klopp, Norman
    Kocher, Thomas
    Kratzer, Wolfgang
    Lichtner, Peter
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Lindström, Jaana
    Lobbens, Stéphane
    Lorentzon, Mattias
    Lu, Yingchang
    Lyssenko, Valeriya
    Magnusson, Patrik K E
    Mahajan, Anubha
    Maillard, Marc
    McArdle, Wendy L
    McKenzie, Colin A
    McLachlan, Stela
    McLaren, Paul J
    Menni, Cristina
    Merger, Sigrun
    Milani, Lili
    Moayyeri, Alireza
    Monda, Keri L
    Morken, Mario A
    Müller, Gabriele
    Müller-Nurasyid, Martina
    Musk, Arthur W
    Narisu, Narisu
    Nauck, Matthias
    Nolte, Ilja M
    Nöthen, Markus M
    Oozageer, Laticia
    Pilz, Stefan
    Rayner, Nigel W
    Renstrom, Frida
    Robertson, Neil R
    Rose, Lynda M
    Roussel, Ronan
    Sanna, Serena
    Scharnagl, Hubert
    Scholtens, Salome
    Schumacher, Fredrick R
    Schunkert, Heribert
    Scott, Robert A
    Sehmi, Joban
    Seufferlein, Thomas
    Shi, Jianxin
    Silventoinen, Karri
    Smit, Johannes H
    Smith, Albert Vernon
    Smolonska, Joanna
    Stanton, Alice V
    Stirrups, Kathleen
    Stott, David J
    Stringham, Heather M
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.
    Swertz, Morris A
    Syvänen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Tayo, Bamidele O
    Thorleifsson, Gudmar
    Tyrer, Jonathan P
    van Dijk, Suzanne
    van Schoor, Natasja M
    van der Velde, Nathalie
    van Heemst, Diana
    van Oort, Floor V A
    Vermeulen, Sita H
    Verweij, Niek
    Vonk, Judith M
    Waite, Lindsay L
    Waldenberger, Melanie
    Wennauer, Roman
    Wilkens, Lynne R
    Willenborg, Christina
    Wilsgaard, Tom
    Wojczynski, Mary K
    Wong, Andrew
    Wright, Alan F
    Zhang, Qunyuan
    Arveiler, Dominique
    Bakker, Stephan J L
    Beilby, John
    Bergman, Richard N
    Bergmann, Sven
    Biffar, Reiner
    Blangero, John
    Boomsma, Dorret I
    Bornstein, Stefan R
    Bovet, Pascal
    Brambilla, Paolo
    Brown, Morris J
    Campbell, Harry
    Caulfield, Mark J
    Chakravarti, Aravinda
    Collins, Rory
    Collins, Francis S
    Crawford, Dana C
    Cupples, L Adrienne
    Danesh, John
    de Faire, Ulf
    den Ruijter, Hester M
    Erbel, Raimund
    Erdmann, Jeanette
    Eriksson, Johan G
    Farrall, Martin
    Ferrannini, Ele
    Ferrières, Jean
    Ford, Ian
    Forouhi, Nita G
    Forrester, Terrence
    Gansevoort, Ron T
    Gejman, Pablo V
    Gieger, Christian
    Golay, Alain
    Gottesman, Omri
    Gudnason, Vilmundur
    Gyllensten, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Genomik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Haas, David W
    Hall, Alistair S
    Harris, Tamara B
    Hattersley, Andrew T
    Heath, Andrew C
    Hengstenberg, Christian
    Hicks, Andrew A
    Hindorff, Lucia A
    Hingorani, Aroon D
    Hofman, Albert
    Hovingh, G Kees
    Humphries, Steve E
    Hunt, Steven C
    Hypponen, Elina
    Jacobs, Kevin B
    Jarvelin, Marjo-Riitta
    Jousilahti, Pekka
    Jula, Antti M
    Kaprio, Jaakko
    Kastelein, John J P
    Kayser, Manfred
    Kee, Frank
    Keinanen-Kiukaanniemi, Sirkka M
    Kiemeney, Lambertus A
    Kooner, Jaspal S
    Kooperberg, Charles
    Koskinen, Seppo
    Kovacs, Peter
    Kraja, Aldi T
    Kumari, Meena
    Kuusisto, Johanna
    Lakka, Timo A
    Langenberg, Claudia
    Le Marchand, Loic
    Lehtimäki, Terho
    Lupoli, Sara
    Madden, Pamela A F
    Männistö, Satu
    Manunta, Paolo
    Marette, André
    Matise, Tara C
    McKnight, Barbara
    Meitinger, Thomas
    Moll, Frans L
    Montgomery, Grant W
    Morris, Andrew D
    Morris, Andrew P
    Murray, Jeffrey C
    Nelis, Mari
    Ohlsson, Claes
    Oldehinkel, Albertine J
    Ong, Ken K
    Ouwehand, Willem H
    Pasterkamp, Gerard
    Peters, Annette
    Pramstaller, Peter P
    Price, Jackie F
    Qi, Lu
    Raitakari, Olli T
    Rankinen, Tuomo
    Rao, D C
    Rice, Treva K
    Ritchie, Marylyn
    Rudan, Igor
    Salomaa, Veikko
    Samani, Nilesh J
    Saramies, Jouko
    Sarzynski, Mark A
    Schwarz, Peter E H
    Sebert, Sylvain
    Sever, Peter
    Shuldiner, Alan R
    Sinisalo, Juha
    Steinthorsdottir, Valgerdur
    Stolk, Ronald P
    Tardif, Jean-Claude
    Tönjes, Anke
    Tremblay, Angelo
    Tremoli, Elena
    Virtamo, Jarmo
    Vohl, Marie-Claude
    Amouyel, Philippe
    Asselbergs, Folkert W
    Assimes, Themistocles L
    Bochud, Murielle
    Boehm, Bernhard O
    Boerwinkle, Eric
    Bottinger, Erwin P
    Bouchard, Claude
    Cauchi, Stéphane
    Chambers, John C
    Chanock, Stephen J
    Cooper, Richard S
    de Bakker, Paul I W
    Dedoussis, George
    Ferrucci, Luigi
    Franks, Paul W
    Froguel, Philippe
    Groop, Leif C
    Haiman, Christopher A
    Hamsten, Anders
    Hayes, M Geoffrey
    Hui, Jennie
    Hunter, David J
    Hveem, Kristian
    Jukema, J Wouter
    Kaplan, Robert C
    Kivimaki, Mika
    Kuh, Diana
    Laakso, Markku
    Liu, Yongmei
    Martin, Nicholas G
    März, Winfried
    Melbye, Mads
    Moebus, Susanne
    Munroe, Patricia B
    Njølstad, Inger
    Oostra, Ben A
    Palmer, Colin N A
    Pedersen, Nancy L
    Perola, Markus
    Pérusse, Louis
    Peters, Ulrike
    Powell, Joseph E
    Power, Chris
    Quertermous, Thomas
    Rauramaa, Rainer
    Reinmaa, Eva
    Ridker, Paul M
    Rivadeneira, Fernando
    Rotter, Jerome I
    Saaristo, Timo E
    Saleheen, Danish
    Schlessinger, David
    Slagboom, P Eline
    Snieder, Harold
    Spector, Tim D
    Strauch, Konstantin
    Stumvoll, Michael
    Tuomilehto, Jaakko
    Uusitupa, Matti
    van der Harst, Pim
    Völzke, Henry
    Walker, Mark
    Wareham, Nicholas J
    Watkins, Hugh
    Wichmann, H-Erich
    Wilson, James F
    Zanen, Pieter
    Deloukas, Panos
    Heid, Iris M
    Lindgren, Cecilia M
    Mohlke, Karen L
    Speliotes, Elizabeth K
    Thorsteinsdottir, Unnur
    Barroso, Inês
    Fox, Caroline S
    North, Kari E
    Strachan, David P
    Beckmann, Jacques S
    Berndt, Sonja I
    Boehnke, Michael
    Borecki, Ingrid B
    McCarthy, Mark I
    Metspalu, Andres
    Stefansson, Kari
    Uitterlinden, André G
    van Duijn, Cornelia M
    Franke, Lude
    Willer, Cristen J
    Price, Alkes L
    Lettre, Guillaume
    Loos, Ruth J F
    Weedon, Michael N
    Ingelsson, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    O'Connell, Jeffrey R
    Abecasis, Goncalo R
    Chasman, Daniel I
    Goddard, Michael E
    Visscher, Peter M
    Hirschhorn, Joel N
    Frayling, Timothy M
    Defining the role of common variation in the genomic and biological architecture of adult human height2014Inngår i: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 46, nr 11, s. 1173-1186Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

  • 270.
    Wood, Angela M.
    et al.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Kaptoge, Stephen
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Butterworth, Adam S.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Willeit, Peter
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.;Med Univ Innsbruck, Innsbruck, Austria..
    Warnakula, Samantha
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Bolton, Thomas
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Paige, Ellie
    Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia..
    Paul, Dirk S.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Sweeting, Michael
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Burgess, Stephen
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.;Univ Cambridge, Cambridge Inst Publ Hlth, MRC Biostat Unit, Cambridge, England..
    Bell, Steven
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Astle, William
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Stevens, David
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Koulman, Albert
    Univ Cambridge, NIHR BRC Nutr Biomarker Lab, Cambridge, England..
    Selmer, Randi M.
    Norwegian Inst Publ Hlth, Oslo, Norway..
    Verschuren, W. M. Monique
    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands.;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands..
    Sato, Shinichi
    Chiba Prefectural Inst Publ Hlth, Chiba, Japan..
    Njolstad, Inger
    Univ Tromso, Dept Community Med, Tromso, Norway..
    Woodward, Mark
    Univ Oxford, Nuffield Dept Populat Hlth, Med Sci Div, Oxford, England.;Univ Sydney, George Inst Global Hlth, Sydney, NSW, Australia.;Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA..
    Salomaa, Veikko
    THL Natl Inst Hlth & Welf, Helsinki, Finland..
    Nordestgaard, Borge G.
    Copenhagen Univ Hosp, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark..
    Yeap, Bu B.
    Univ Western Australia, Sch Med, Perth, WA, Australia.;Fiona Stanley Hosp, Perth, WA, Australia.;Harry Perkins Inst Med Res, Perth, WA, Australia..
    Fletcher, Astrid
    London Sch Hyg & Trop Med, London, England..
    Melander, Olle
    Lund Univ, Dept Clin Sci, Malmo, Sweden..
    Kuller, Lewis H.
    Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA..
    Balkau, Beverley
    INSERM, UMRS 1018, CESP, Villejuif, France..
    Marmot, Michael
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Koenig, Wolfgang
    Tech Univ Munich, Deutsch Herzzentrum Munchen 92, DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.;Univ Ulm, Med Ctr, Ulm, Germany..
    Casiglia, Edoardo
    Univ Padua, Dept Med, Padua, Italy..
    Cooper, Cyrus
    Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England..
    Arndt, Volker
    German Canc Res Ctr, Heidelberg, Germany..
    Franco, Oscar H.
    Erasmus Univ, Med Ctr, Rotterdam, Netherlands..
    Wennberg, Patrik
    Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden..
    Gallacher, John
    Cardiff Univ, Dept Primary Care & Publ Hlth, Cardiff, S Glam, Wales..
    de la Camara, Agustin Gomez
    CIBERESP, Octubre Res Inst 12, Madrid, Spain..
    Volzke, Henry
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany..
    Dahm, Christina C.
    Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark..
    Dale, Caroline E.
    UCL, UCL Inst Hlth Informat, Farr Inst Hlth Informat Res, London, England..
    Bergmann, Manuela M.
    German Inst Human Nutr, Potsdam, Germany..
    Crespo, Carlos J.
    Portland State Univ, Sch Community Hlth, Portland, OR 97207 USA..
    van der Schouw, Yvonne T.
    Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands..
    Kaaks, Rudolf
    German Canc Res Ctr, Heidelberg, Germany..
    Simons, Leon A.
    Univ New South Wales, St Vincents Clin Sch, Sydney, NSW, Australia..
    Lagiou, Pagona
    Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Athens, Greece.;Harvard TH Chan Sch Publ Hlth, Boston, MA USA..
    Schoufour, Josje D.
    Erasmus Univ, Med Ctr, Rotterdam, Netherlands..
    Boer, Jolanda M. A.
    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands..
    Key, Timothy J.
    Univ Oxford, Nuffield Dept Populat Hlth, Med Sci Div, Oxford, England..
    Rodriguez, Beatriz
    Univ Hawaii, Off Publ Hlth Studies, Honolulu, HI 96822 USA..
    Moreno-Iribas, Conchi
    Navarra Inst Hlth Res, IdiSNA, Inst Salud Publ Navarra, Pamplona, Spain.;Red Invest Serv Salud Enfermedades Cronicas REDIS, Pamplona, Spain..
    Davidson, Karina W.
    Columbia Univ Irving, Med Ctr, New York, NY USA..
    Taylor, James O.
    East Boston Neighborhood Hlth Ctr, Boston, MA USA..
    Sacerdote, Carlotta
    Citta Salute Sci Torino Hosp, Turin, Italy..
    Wallace, Robert B.
    Univ Iowa, Coll Publ Hlth, Iowa City, IA USA..
    Quiros, J. Ramon
    Consejeria Sanidad Principado Asturias, Oviedo, Asturias, Spain..
    Tumino, Rosario
    ASP, Civic M Arezzo Hosp, Ragusa, Italy..
    Blazer, Dan G., II
    Duke Univ, Duke Div Sch, Durham, NC USA..
    Linneberg, Allan
    Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark..
    Daimon, Makoto
    Hirosaki Univ, Dept Endocrinol & Metab, Hirosaki, Aomori, Japan..
    Panico, Salvatore
    Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy..
    Howard, Barbara
    Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA..
    Skeie, Guri
    UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway..
    Strandberg, Timo
    Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland..
    Weiderpass, Elisabete
    UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.;Canc Registry Norway, Inst Population Based Canc Res, Oslo, Norway.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Univ Helsinki, Epidemiol Grp, Folkhalsan Res Ctr, Fac Med, Helsinki, Finland..
    Nietert, Paul J.
    Univ South Carolina, Med, Charleston, SC USA..
    Psaty, Bruce M.
    Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98195 USA.;Univ Washington, Cardiovasc Hlth Res Unit, Dept Epidemiol, Seattle, WA 98195 USA.;Univ Washington, Cardiovasc Hlth Res Unit, Dept Hlth Serv, Seattle, WA 98195 USA.;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA..
    Kromhout, Daan
    Wageningen Univ, Dept Agrotechnol & Food Sci, Wageningen, Netherlands.;Univ Groningen, Fac Med Sci, Groningen, Netherlands.;Yale Univ, Sch Med, New Haven, CT USA..
    Salamanca-Fernandez, Elena
    Univ Granada, Hospit Univ Granada, Inst Invest Biosanitaria ibs GRANADA, Escuela Andaluza Salud Publ, Granada, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain..
    Kiechl, Stefan
    Med Univ Innsbruck, Innsbruck, Austria..
    Krumholz, Harlan M.
    Grioni, Sara
    Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy..
    Palli, Domenico
    Canc Res & Prevent Inst ISPO, Florence, Italy..
    Huerta, Jose M.
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.;IMIB Arrixaca, Murcia Reg Hlth Council, Murcia, Spain..
    Price, Jackie
    Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland..
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.
    Arriola, Larraitz
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.;Basque Govt, Inst Biodonostia, San Sebastian, Spain..
    Arima, Hisatomi
    Univ Sydney, Sydney, NSW, Australia.;Royal Prince Alfred Hosp, Sydney, NSW, Australia.;Kyushu Univ, Dept Prevent Med & Publ Hlth, Fukuoka, Japan..
    Travis, Ruth C.
    Univ Oxford, Nuffield Dept Populat Hlth, Med Sci Div, Oxford, England..
    Panagiotakos, Demosthenes B.
    Harokopio Univ, Sch Hlth Sci & Educ, Athens, Greece..
    Karakatsani, Anna
    Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Athens, Greece..
    Trichopoulou, Antonia
    Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Athens, Greece..
    Kuhn, Tilman
    German Canc Res Ctr, Heidelberg, Germany..
    Grobbee, Diederick E.
    Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands..
    Barrett-Connor, Elizabeth
    Univ Calif San Diego, Dept Family Med & Publ Hlth, San Diego, CA 92103 USA..
    van Schoor, Natasja
    Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands..
    Boeing, Heiner
    German Inst Human Nutr, Potsdam, Germany..
    Overvad, Kim
    Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.;Aalborg Univ Hosp, Aalborg, Denmark..
    Kauhanen, Jussi
    Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland..
    Wareham, Nick
    Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England..
    Langenberg, Claudia
    Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England..
    Forouhi, Nita
    Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England..
    Wennberg, Maria
    Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden..
    Despres, Jean-Pierre
    Laval Univ, Dept Kinesiol, Quebec City, PQ, Canada..
    Cushman, Mary
    Univ Vermont, Dept Med, Burlington, VT USA..
    Cooper, Jackie A.
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Rodriguez, Carlos J.
    Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA.;Wake Forest Baptist Med Ctr, Winston Salem, NC USA..
    Sakurai, Masaru
    Kanazawa Med Univ, Dept Social & Environm Med, Kanazawa, Ishikawa, Japan..
    Shaw, Jonathan E.
    Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia..
    Knuiman, Matthew
    Populat Med Res Inst, Busselton, WA, Australia.;Univ Western Australia, Sch Populat & Global Hlth, Perth, WA, Australia..
    Voortman, Trudy
    Erasmus Univ, Med Ctr, Rotterdam, Netherlands..
    Meisinger, Christa
    Helmholtz Zentrum Munchen German Res Ctr Environm, Munich, Germany..
    Tjonneland, Anne
    Danish Canc Soc Res Ctr, Copenhagen, Denmark..
    Brenner, Hermann
    German Canc Res Ctr, Heidelberg, Germany.;Heidelberg Univ, Div Clin Epidemiol & Aging Res, Heidelberg, Germany..
    Palmieri, Luigi
    Ist Supe Sanita, Rome, Italy..
    Dallongeville, Jean
    Inst Pasteur, Lille, France..
    Brunner, Eric J.
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Assmann, Gerd
    Assmann Stiftung Pravent, Munster, Germany..
    Trevisan, Maurizio
    CUNY City Coll, New York, NY USA..
    Gillum, Richard F.
    Howard Univ Hosp, Washington, DC USA..
    Ford, Ian
    Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland..
    Sattar, Naveed
    Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland..
    Lazo, Mariana
    Johns Hopkins Univ, Sch Med, Baltimore, MD USA..
    Thompson, Simon G.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Ferrari, Pietro
    Int Agcy Res Canc, Lyon, France..
    Leon, David A.
    London Sch Hyg & Trop Med, London, England..
    Smith, George Davey
    Univ Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England..
    Peto, Richard
    Jackson, Rod
    Univ Auckland, Sch Populat Hlth, Auckland, New Zealand..
    Banks, Emily
    Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia..
    Di Angelantonio, Emanuele
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Danesh, John
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies2018Inngår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 391, nr 10129, s. 1513-1523Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease.

    Methods: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank). We characterised dose-response associations and calculated hazard ratios (HRs) per 100 g per week of alcohol (12.5 units per week) across 83 prospective studies, adjusting at least for study or centre, age, sex, smoking, and diabetes. To be eligible for the analysis, participants had to have information recorded about their alcohol consumption amount and status (ie, non-drinker vs current drinker), plus age, sex, history of diabetes and smoking status, at least 1 year of follow-up after baseline, and no baseline history of cardiovascular disease. The main analyses focused on current drinkers, whose baseline alcohol consumption was categorised into eight predefined groups according to the amount in grams consumed per week. We assessed alcohol consumption in relation to all-cause mortality, total cardiovascular disease, and several cardiovascular disease subtypes. We corrected HRs for estimated long-term variability in alcohol consumption using 152 640 serial alcohol assessments obtained some years apart (median interval 5.6 years [5th-95th percentile 1.04-13.5]) from 71 011 participants from 37 studies.

    Findings: In the 599 912 current drinkers included in the analysis, we recorded 40 310 deaths and 39 018 incident cardiovascular disease events during 5.4 million person-years of follow-up. For all-cause mortality, we recorded a positive and curvilinear association with the level of alcohol consumption, with the minimum mortality risk around or below 100 g per week. Alcohol consumption was roughly linearly associated with a higher risk of stroke (HR per 100 g per week higher consumption 1.14, 95% CI, 1.10-1.17), coronary disease excluding myocardial infarction (1.06, 1.00-1.11), heart failure (1.09, 1.03-1.15), fatal hypertensive disease (1.24, 1.15-1.33); and fatal aortic aneurysm (1.15, 1.03-1.28). By contrast, increased alcohol consumption was loglinearly associated with a lower risk of myocardial infarction (HR 0.94, 0.91-0.97). In comparison to those who reported drinking >0-<= 100 g per week, those who reported drinking >100-<= 200 g per week, >200-<= 350 g per week, or >350 g per week had lower life expectancy at age 40 years of approximately 6 months, 1-2 years, or 4-5 years, respectively.

    Interpretation: In current drinkers of alcohol in high-income countries, the threshold for lowest risk of all-cause mortality was about 100 g/week. For cardiovascular disease subtypes other than myocardial infarction, there were no clear risk thresholds below which lower alcohol consumption stopped being associated with lower disease risk. These data support limits for alcohol consumption that are lower than those recommended in most current guidelines.

  • 271. Wormser, David
    et al.
    Di Angelantonio, Emanuele
    Kaptoge, Stephen
    Wood, Angela M.
    Gao, Pei
    Sun, Qi
    Walldius, Goeran
    Selmer, Randi
    Verschuren, W. M. Monique
    Bueno-de-Mesquita, H. Bas
    Engstrom, Gunnar
    Ridker, Paul M.
    Njolstad, Inger
    Iso, Hiroyasu
    Holme, Ingar
    Giampaoli, Simona
    Tunstall-Pedoe, Hugh
    Gaziano, J. Michael
    Brunner, Eric
    Kee, Frank
    Tosetto, Alberto
    Meisinger, Christa
    Brenner, Hermann
    Ducimetiere, Pierre
    Whincup, Peter H.
    Tipping, Robert W.
    Ford, Ian
    Cremer, Peter
    Hofman, Albert
    Wilhelmsen, Lars
    Clarke, Robert
    de Boer, Ian H.
    Jukema, J. Wouter
    Ibanez, Alejandro Marin
    Lawlor, Debbie A.
    D'Agostino, Ralph B., Sr.
    Rodriguez, Beatriz
    Casiglia, Edoardo
    Stehouwer, Coen D. A.
    Simons, Leon A.
    Nietert, Paul J.
    Barrett-Connor, Elizabeth
    Panagiotakos, Demosthenes B.
    Bjorkelund, Cecilia
    Strandberg, Timo E.
    Wassertheil-Smoller, Sylvia
    Blazer, Dan G.
    Meade, Tom W.
    Welin, Lennart
    Svärdsudd, Kurt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Woodward, Mark
    Nissinen, Aulikki
    Kromhout, Daan
    Jorgensen, Torben
    Tilvis, Reijo S.
    Guralnik, Jack M.
    Rosengren, Annika
    Taylor, James O.
    Kiechl, Stefan
    Dagenais, Gilles R.
    Fowkes, F. Gerry R.
    Wallace, Robert B.
    Khaw, Kay-Tee
    Shaffer, Jonathan A.
    Visser, Marjolein
    Kauhanen, Jussi
    Salonen, Jukka T.
    Gallacher, John
    Ben-Shlomo, Yoav
    Kitamura, Akihiko
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Wennberg, Patrik
    Kiyohara, Yutaka
    Daimon, Makoto
    Gomez de la Camara, Agustin
    Cooper, Jackie A.
    Onat, Altan
    Devereux, Richard
    Mukamal, Kenneth J.
    Dankner, Rachel
    Knuiman, Matthew W.
    Crespo, Carlos J.
    Gansevoort, Ron T.
    Goldbourt, Uri
    Nordestgaard, Borge G.
    Shaw, Jonathan E.
    Mussolino, Michael
    Nakagawa, Hidaeki
    Fletcher, Astrid
    Kuller, Lewis H.
    Gillum, Richard F.
    Gudnason, Vilmundur
    Assmann, Gerd
    Wald, Nicholas
    Jousilahti, Pekka R.
    Greenland, Philip
    Trevisan, Maurizio
    Ulmer, Hanno
    Butterworth, Adam S.
    Folsom, Aaron R.
    Davey-Smith, George
    Hu, Frank B.
    Danesh, John
    Tipping,
    Ford, CE
    Simpson,
    Walldius, G
    Jungner, I
    Folsom, AR
    Demerath,
    Franceschini, N
    Lutsey,
    Panagiotakos, DB
    Pitsavos, C
    Chrysohoou, C
    Stefanadis,
    Shaw, JE
    Atkins, R
    Zimmet, PZ
    Barr, EL
    Knuiman, MW
    Whincup,
    Wannamethee,
    Morris,
    Willeit, J
    Kiechl,
    Weger,
    Oberhollenzer, F
    Wald, N
    Ebrahim, S
    Lawlor, DA
    Gallacher, J
    Ben-Shlomo,
    Yarnell,
    Casiglia,
    Tikhonoff,
    Greenland, P
    Shay,
    Garside,
    Nietert,
    Sutherland, SE
    Bachman, DL
    Keil,
    de Boer, IH
    Kizer, JR
    Psaty, BM
    Mukamal, KJ
    Nordestgaard, BG
    Tybjærg-Hansen A, A
    Jensen, GB
    Schnohr, P
    Giampaoli, S
    Palmieri,
    Panico,
    Pilotto, L
    Vanuzzo, D
    de la Cámara, AG
    Simons, LA
    Simons, J
    McCallum, J
    Friedlander,
    Gerry, F
    Fowkes, R
    Price, JF
    Lee, AJ
    Taylor, Taylor JO
    Guralnik, JM
    Phillips, CL
    Kohout, FJ
    Kohout, FJ
    Cornoni-Huntley, JC
    Guralnik, JM
    Blazer, DG
    Guralnik,
    Phillips, CL
    Phillips, CL
    Guralnik, JM
    Khaw, KT
    Wareham, NJ
    Wareham, NJ
    Brenner, H
    Schöttker, B
    Müller, H
    Rothenbacher, D
    Wennberg, P
    Jansson, JH
    Nissinen, A
    Donfrancesco, C
    Giampaoli, S
    Woodward, M
    Vartiainen, E
    Jousilahti, PR
    Harald, K
    Salomaa, V
    D'Agostino, RB
    Vasan, RS
    Fox, CS
    Pencina, MJ
    Daimon, M
    Oizumi, T
    Kayama, T
    Kato, T
    Bladbjerg, EM
    Danesh, J
    Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis2012Inngår i: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 41, nr 5, s. 1419-1433Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.

    Methods

    We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.

    Results

    For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.

    Conclusion

    Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

  • 272. Wormser, David
    et al.
    Kaptoge, Stephen
    Di Angelantonio, Emanuele
    Wood, Angela M
    Pennells, Lisa
    Thompson, Alex
    Sarwar, Nadeem
    Kizer, Jorge R
    Lawlor, Debbie A
    Nordestgaard, Børge G
    Ridker, Paul
    Salomaa, Veikko
    Stevens, June
    Woodward, Mark
    Sattar, Naveed
    Collins, Rory
    Thompson, Simon G
    Whitlock, Gary
    Ärnlöv, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).
    Risérus, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Klinisk nutrition och metabolism.
    Ingelsson, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Danesh, John
    Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies2011Inngår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 377, nr 9771, s. 1085-1095Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND:

    Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction when information is available for other risk factors. We studied the separate and combined associations of body-mass index (BMI), waist circumference, and waist-to-hip ratio with risk of first-onset cardiovascular disease.

    METHODS:

    We used individual records from 58 cohorts to calculate hazard ratios (HRs) per 1 SD higher baseline values (4.56 kg/m(2) higher BMI, 12.6 cm higher waist circumference, and 0.083 higher waist-to-hip ratio) and measures of risk discrimination and reclassification. Serial adiposity assessments were used to calculate regression dilution ratios.

    RESULTS:

    Individual records were available for 221,934 people in 17 countries (14,297 incident cardiovascular disease outcomes; 1.87 million person-years at risk). Serial adiposity assessments were made in up to 63,821 people (mean interval 5.7 years [SD 3.9]). In people with BMI of 20 kg/m(2) or higher, HRs for cardiovascular disease were 1.23 (95% CI 1.17-1.29) with BMI, 1.27 (1.20-1.33) with waist circumference, and 1.25 (1.19-1.31) with waist-to-hip ratio, after adjustment for age, sex, and smoking status. After further adjustment for baseline systolic blood pressure, history of diabetes, and total and HDL cholesterol, corresponding HRs were 1.07 (1.03-1.11) with BMI, 1.10 (1.05-1.14) with waist circumference, and 1.12 (1.08-1.15) with waist-to-hip ratio. Addition of information on BMI, waist circumference, or waist-to-hip ratio to a cardiovascular disease risk prediction model containing conventional risk factors did not importantly improve risk discrimination (C-index changes of -0.0001, -0.0001, and 0.0008, respectively), nor classification of participants to categories of predicted 10-year risk (net reclassification improvement -0.19%, -0.05%, and -0.05%, respectively). Findings were similar when adiposity measures were considered in combination. Reproducibility was greater for BMI (regression dilution ratio 0.95, 95% CI 0.93-0.97) than for waist circumference (0.86, 0.83-0.89) or waist-to-hip ratio (0.63, 0.57-0.70).

    INTERPRETATION:

    BMI, waist circumference, and waist-to-hip ratio, whether assessed singly or in combination, do not importantly improve cardiovascular disease risk prediction in people in developed countries when additional information is available for systolic blood pressure, history of diabetes, and lipids.

    FUNDING:

    British Heart Foundation and UK Medical Research Council.

  • 273.
    Wu, Jason H. Y.
    et al.
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia..
    Foote, Celine
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia.;Concord Repatriat Gen Hosp, Sydney, NSW, Australia..
    Blomster, Juuso
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia.;Univ Turku, Turku, Finland.;Univ Gothenberg, Sahlgrenska Acad, Gothenburg, Sweden..
    Toyama, Tadashi
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia..
    Perkovic, Vlado
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia.;Royal Prince Alfred Hosp, Sydney, NSW, Australia..
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR). Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi. Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia..
    Neal, Bruce
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia.;Univ London Imperial Coll Sci Technol & Med, London, England..
    Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis2016Inngår i: The Lancet Diabetes and Endocrinology, ISSN 2213-8587, E-ISSN 2213-8595, Vol. 4, nr 5, s. 411-419Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background In patients with type 2 diabetes, sodium-glucose cotransporter-2 (SGLT2) inhibitors are known to reduce glucose concentrations, blood pressure, and weight, but to increase LDL cholesterol and the incidence of urogenital infections. Protection against cardiovascular events has also been reported, as have possible increased risks of adverse outcomes such as ketoacidosis and bone fracture. We aimed to establish the effects of SGLT2 inhibitors on cardiovascular events, death, and safety outcomes in adults with type 2 diabetes, both overall and separately for individual drugs. Methods In this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Library, and websites of US, European, and Japanese regulatory authorities from Jan 1, 1950, to Sept 30, 2015, for data from prospective randomised controlled trials assessing the effects of SGLT2 treatment compared with controls. We excluded duplicate reports, trials of compound drugs, trials that lasted 7 days or fewer, trials that did not report on outcomes of interest, and articles that presented pooled trial data for which the individual trials could not be identified. We extracted data in duplicate using a standardised approach. The primary outcome was major adverse cardiovascular events. Secondary outcomes were cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, admission to hospital for unstable angina, heart failure, and all-cause mortality. We estimated summary relative risks with fixed-effects meta-analysis, with the I-2 statistic used to estimate heterogeneity of results beyond chance. Findings The analyses included data from six regulatory submissions (37 525 participants) and 57 published trials (33 385 participants), which provided data for seven different SGLT2 inhibitors. SGLT2 inhibitors protected against the risk of major adverse cardiovascular events (relative risk 0.84 [95% CI 0.75-0.95]; p=0.006), cardiovascular death (0.63 [0.51-0.77]; p<0.0001), heart failure (0.65 [0.50-0.85]; p=0.002), and death from any cause (0.71 [0.61-0.83]; p<0.0001). No clear effect was apparent for non-fatal myocardial infarction (0.88 [0.72-1.07]; p=0.18) or angina (0.95 [0.73-1.23]; p=0.70), but we noted an adverse effect for non-fatal stroke (1.30 [1.00-1.68]; p=0.049). We noted no clear evidence that the individual drugs had different effects on cardiovascular outcomes or death (all I I-2 < 43%). Safety analyses showed consistent increased risks of genital infections (regulatory submissions 4.75 [4.00-5.63]; scientific reports 2.88 [2.48-3.34]), but findings for some safety outcomes varied depending on whether anlayses were based on data extracted from regulatory submissions or trials reported in the scientific literature. Interpretation These data suggest net protection of SGLT2 inhibitors against cardiovascular outcomes and death. The efficacy results were driven by findings for empagliflozin (the only SGLT2 inhibitor for which data from a dedicated long-term cardiovascular safety trial have been reported), although results for the other drugs in the class were not clearly different. Adverse events were more difficult to quantify than was efficacy, with the effects of individual drugs in the class seeming to differ for some safety outcomes. Results from ongoing studies will be crucial to substantiate these findings across the drug class, but the available data provide a strong rationale to expect benefit from use of SGLT2 inhibitors in patients with type 2 diabetes at high risk of cardiovascular events.

  • 274.
    Yi-Ting, Lin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.
    Fall, Tove
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi.
    Gustafsson, Stefan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi.
    Ingelsson, Erik
    Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.
    Arnlov, Johan
    Karolinska Inst, Dept Neurobiol, Div Family Med & Primary Care, Stockholm, Sweden.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk epidemiologi.
    Engström, Gunnar
    Lund Univ, Dept Clin Sci, Cardiovasc Epidemiol, Lund, Sweden.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.
    Use of Proteomics to Investigate Blood Pressure Progress in the Elderly2018Inngår i: Journal of Hypertension, ISSN 0263-6352, E-ISSN 1473-5598, Vol. 36, s. E115-E115Artikkel i tidsskrift (Annet vitenskapelig)
  • 275.
    Yi-Ting, Lin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi. Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 807, Taiwan.
    Fall, Tove
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.
    Hammar, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi.
    Gustafsson, Stefan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi.
    Ingelsson, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
    Ärnlöv, Johan
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, S-14152 Huddinge, Sweden;Dalarna Univ, Sch Hlth & Social Studies, S-79131 Falun, Sweden.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk epidemiologi.
    Engstrom, Gunnar
    Lund Univ, Dept Clin Sci, Cardiovasc Epidemiol, S-21428 Malmo, Sweden.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk epidemiologi. Univ New South Wales, George Inst Global Hlth, Sydney, NSW 2042, Australia.
    Proteomic Analysis of Longitudinal Changes in Blood Pressure2019Inngår i: JOURNAL OF CLINICAL MEDICINE, ISSN 2077-0383, Vol. 8, nr 10, artikkel-id 1585Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Hypertension is the leading risk factor for premature death worldwide. The identification of modifiable causes of hypertension remains an imperative task. We aimed to investigate associations between 79 proteins implicated in cardiovascular disease and longitudinal blood pressure (BP) changes in three Swedish prospective cohorts. In a discovery phase, we investigated associations between baseline circulating protein levels assessed with a proximity extension assay and BP stage progression at follow-up 5 years later among persons without BP-lowering drugs at baseline in two independent community-based cohorts from the Prospective Investigation of the Vasculature in Uppsala Seniors study (PIVUS) and the Uppsala Longitudinal Study of Adult Men (ULSAM). We used an independent cohort, the Malmo Diet and Cancer Study (MDC), for replication. The primary outcome of BP stage progression was defined as per the 2017 AHA/ACC (American Heart Association/American College of Cardiology) Guideline BP categories. We also investigated associations of protein levels with changes in BP on a continuous scale, and meta-analyzed all three cohorts. Levels of renin were associated with BP stage progression with a 5% false discovery rate (FDR) in the ULSAM (n = 238) and PIVUS (n = 566) cohorts, but we could not replicate this association in the MDC cohort (n = 2659). The association in the discovery cohorts was modest, with an odds ratio for BP stage progression over 5 years of 1.33 (95% confidence interval 1.14 to 1.56) per standard deviation of baseline renin. In conclusion, we could not find any novel robust associations with longitudinal BP increase in a proximity extension assay-based proteomics investigation in three cohorts.

  • 276.
    Zethelius, Björn
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Berglund, Lars
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Ingelsson, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Basu, Samar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Klinisk nutrition och metabolism.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Venge, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Arnlöv, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Use of multiple biomarkers to improve the prediction of death from cardiovascular causes2008Inngår i: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 358, nr 20, s. 2107-2116Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The incremental usefulness of adding multiple biomarkers from different disease pathways for predicting the risk of death from cardiovascular causes has not, to our knowledge, been evaluated among the elderly. METHODS: We used data from the Uppsala Longitudinal Study of Adult Men (ULSAM), a community-based cohort of elderly men, to investigate whether a combination of biomarkers that reflect myocardial cell damage, left ventricular dysfunction, renal failure, and inflammation (troponin I, N-terminal pro-brain natriuretic peptide, cystatin C, and C-reactive protein, respectively) improved the risk stratification of a person beyond an assessment that was based on the established risk factors for cardiovascular disease (age, systolic blood pressure, use or nonuse of antihypertensive treatment, total cholesterol, high-density lipoprotein cholesterol, use or nonuse of lipid-lowering treatment, presence or absence of diabetes, smoking status, and body-mass index). RESULTS: During follow-up (median, 10.0 years), 315 of the 1135 participants in our study (mean age, 71 years at baseline) died; 136 deaths were the result of cardiovascular disease. In Cox proportional-hazards models adjusted for established risk factors, all of the biomarkers significantly predicted the risk of death from cardiovascular causes. The C statistic increased significantly when the four biomarkers were incorporated into a model with established risk factors, both in the whole cohort (C statistic with biomarkers vs. without biomarkers, 0.766 vs. 0.664; P<0.001) and in the group of 661 participants who did not have cardiovascular disease at baseline (0.748 vs. 0.688, P=0.03). The improvement in risk assessment remained strong when it was estimated by other statistical measures of model discrimination, calibration, and global fit. CONCLUSIONS: Our data suggest that in elderly men with or without prevalent cardiovascular disease, the simultaneous addition of several biomarkers of cardiovascular and renal abnormalities substantially improves the risk stratification for death from cardiovascular causes beyond that of a model that is based only on established risk factors.

  • 277.
    Zhou, Bin
    et al.
    Imperial Coll London, London W2 1PG, England..
    Bentham, James
    Imperial Coll London, London W2 1PG, England..
    Di Cesare, Mariachiara
    Middlesex Univ, London N17 8HR, England..
    Bixby, Honor
    Imperial Coll London, London W2 1PG, England..
    Danaei, Goodarz
    Harvard TH Chan Sch Publ Hlth, Boston, MA USA..
    Cowan, Melanie J.
    WHO, Geneva, Switzerland..
    Paciorek, Christopher J.
    Univ Calif Berkeley, Berkeley, CA 94720 USA..
    Singh, Gitanjali
    Tufts Univ, Medford, MA USA..
    Hajifathalian, Kaveh
    Harvard TH Chan Sch Publ Hlth, Boston, MA USA..
    Bennett, James E.
    Imperial Coll London, London W2 1PG, England..
    Taddei, Cristina
    Imperial Coll London, London W2 1PG, England..
    Bilano, Ver
    Imperial Coll London, London W2 1PG, England..
    Carrillo-Larco, Rodrigo M.
    Univ Peruana Cayetano Heredia, Lima, Peru..
    Djalalinia, Shirin
    Univ Tehran Med Sci, Tehran, Iran.;Noncommunicable Dis Res Ctr, Shiraz, Iran..
    Khatibzadeh, Shahab
    Brandeis Univ, Waltham, MA 02254 USA..
    Lugero, Charles
    Mulago Hosp, Kampala, Uganda..
    Peykari, Niloofar
    Univ Tehran Med Sci, Tehran, Iran.;Noncommunicable Dis Res Ctr, Shiraz, Iran..
    Zhang, Wan Zhu
    Mulago Hosp, Kampala, Uganda..
    Lu, Yuan
    Yale Univ, New Haven, CT 06520 USA..
    Stevens, Gretchen A.
    WHO, Geneva, Switzerland..
    Riley, Leanne M.
    WHO, Geneva, Switzerland..
    Bovet, Pascal
    Univ Lausanne, CH-1015 Lausanne, Switzerland.;Univ Lausanne, CH-1015 Lausanne, Switzerland.;Minist Hlth, Mt Fleuri, Seychelles.;Minist Hlth, Mt Fleuri, Seychelles..
    Elliott, Paul
    Imperial Coll London, London W2 1PG, England..
    Gu, Dongfeng
    Natl Ctr Cardiovasc Dis, Beijing, Peoples R China.;Natl Ctr Cardiovasc Dis, Beijing, Peoples R China..
    Ikeda, Nayu
    Natl Inst Hlth & Nutr, Tokyo, Japan..
    Jackson, Rod T.
    Univ Auckland, Auckland 1, New Zealand..
    Joffres, Michel
    Simon Fraser Univ, Burnaby, BC V5A 1S6, Canada..
    Kengne, Andre Pascal
    South African Med Res Council, Cape Town, South Africa..
    Laatikainen, Tiina
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Lam, Tai Hing
    Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China..
    Laxmaiah, Avula
    Natl Inst Nutr, Hyderabad, Andhra Pradesh, India..
    Liu, Jing
    Capital Med Univ, Beijing An Zhen Hosp, Beijing, Peoples R China..
    Miranda, J. Jaime
    Univ Peruana Cayetano Heredia, Lima, Peru..
    Mondo, Charles K.
    Mulago Hosp, Kampala, Uganda..
    Neuhauser, Hannelore K.
    Robert Koch Inst, Berlin, Germany..
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Smeeth, Liam
    London Sch Hyg & Trop Med, London, England..
    Soric, Maroje
    Univ Zagreb, Zagreb 41000, Croatia..
    Woodward, Mark
    Univ Sydney, Sydney, NSW 2006, Australia..
    Ezzati, Majid
    Imperial Coll London, London W2 1PG, England..
    Abarca-Gomez, Leandra
    Caja Costarricense Seguro Social, San Jose, Costa Rica..
    Abdeen, Ziad A.
    Al Quds Univ, Jerusalem, Israel..
    Rahim, Hanan Abdul
    Qatar Univ, Doha, Qatar..
    Abu-Rmeileh, Niveen M.
    Birzeit Univ, Birzeit, Israel..
    Acosta-Cazares, Benjamin
    Inst Mexicano Seguro Social, Mexico City, DF, Mexico..
    Adams, Robert
    Univ Adelaide, Adelaide, SA 5005, Australia..
    Aekplakorn, Wichai
    Mahidol Univ, Salaya, Thailand..
    Afsana, Kaosar
    BRAC, Dhaka, Bangladesh..
    Aguilar-Salinas, Carlos A.
    Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico..
    Agyemang, Charles
    Univ Amsterdam, NL-1012 WX Amsterdam, Netherlands..
    Ahmadvand, Alireza
    Noncommunicable Dis Res Ctr, Shiraz, Iran..
    Ahrens, Wolfgang
    Leibniz Institute for Prevention Research and Epi, Bremen, Germany..
    Al Raddadi, Rajaa
    Minist Hlth, Riyadh, Saudi Arabia..
    Al Woyatan, Rihab
    Minist Hlth, Kuwait, Kuwait..
    Ali, Mohamed M.
    WHO, Reg Off Eastern Mediterranean, Cairo, Egypt..
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Strassen, Luxembourg..
    Aly, Eman
    WHO, Reg Off Eastern Mediterranean, Cairo, Egypt..
    Amouyel, Philippe
    Lille Univ & Hosp, Lille, France..
    Amuzu, Antoinette
    London Sch Hyg & Trop Med, London, England..
    Andersen, Lars Bo
    Sogn & Fjordane Univ Coll, Forde, Norway..
    Anderssen, Sigmund A.
    Norwegian Sch Sport Sci, Oslo, Norway..
    Angquist, Lars
    Bispebjerg Hosp, Copenhagen, Denmark.;Frederiksberg Univ Hosp, Frederiksberg, Denmark..
    Anjana, Ranjit Mohan
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India..
    Ansong, Daniel
    Komfo Anokye Teaching Hosp, Kumasi, Ghana..
    Aounallah-Skhiri, Hajer
    Natl Inst Publ Hlth, Tunis, Tunisia..
    Araujo, Joana
    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
    Ariansen, Inger
    Norwegian Inst Publ Hlth, Oslo, Norway..
    Aris, Tahir
    Minist Hlth Malaysia, Putrajaya, Malaysia..
    Arlappa, Nimmathota
    Natl Inst Nutr, Hyderabad, Andhra Pradesh, India..
    Aryal, Krishna
    Nepal Hlth Res Council, Kathmandu, Nepal..
    Arveiler, Dominique
    Strasbourg Univ & Hosp, Strasbourg, France..
    Assah, Felix K.
    Univ Yaounde I, Yaounde, Cameroon..
    Assuncao, Maria Cecilia F.
    Univ Fed Pelotas, Pelotas, RS, Brazil..
    Avdicova, Maria
    Reg Author Publ Hlth, Banska Bystrica, Slovakia..
    Azevedo, Ana
    Univ Porto, Sch Med, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
    Azizi, Fereidoun
    Shahid Beheshti Univ Med Sci, Tehran, Iran..
    Babu, Bontha V.
    Indian Council Med Res, New Delhi, India..
    Bahijri, Suhad
    King Abdulaziz Univ, Jeddah, Saudi Arabia..
    Balakrishna, Nagalla
    Natl Inst Nutr, Hyderabad, Andhra Pradesh, India..
    Bandosz, Piotr
    Med Univ Gdansk, Gdansk, Poland..
    Banegas, Jose R.
    Univ Autonoma Madrid, E-28049 Madrid, Spain..
    Barbagallo, Carlo M.
    Univ Palermo, I-90133 Palermo, Italy..
    Barcelo, Alberto
    Pan Amer Hlth Org, Washington, DC USA..
    Barkat, Amina
    Univ Mohammed V Rabat, Rabat, Morocco..
    Barros, Aluisio J. D.
    Barros, Mauro V.
    Univ Fed Pelotas, Pelotas, RS, Brazil..
    Bata, Iqbal
    Dalhousie Univ, Halifax, NS B3H 3J5, Canada..
    Batieha, Anwar M.
    Jordan Univ Sci & Technol, Irbid, Jordan..
    Baur, Louise A.
    Univ Sydney, Sydney, NSW 2006, Australia..
    Beaglehole, Robert
    Univ Auckland, Auckland 1, New Zealand..
    Ben Romdhane, Habiba
    Univ Tunis El Manar, Tunis, Tunisia..
    Benet, Mikhail
    Univ Med Sci, Havana, Cuba..
    Benson, Lowell S.
    Univ Utah, Sch Med, Salt Lake City, UT 84112 USA..
    Bernabe-Ortiz, Antonio
    Univ Peruana Cayetano Heredia, Lima, Peru..
    Bernotiene, Gailute
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania..
    Bettiol, Heloisa
    Univ Sao Paulo, BR-05508 Sao Paulo, Brazil..
    Bhagyalaxmi, Aroor
    BJ Med Coll, Ahmadabad, Gujarat, India..
    Bharadwaj, Sumit
    Chirayu Med Coll, Bhopal, India..
    Bhargava, Santosh K.
    SL Jain Hosp, Delhi, India..
    Bi, Yufang
    Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China..
    Bikbov, Mukharram
    Ufa Eye Res Inst, Ufa, Russia..
    Bjerregaard, Peter
    Univ Southern Denmark, Odense, Denmark.;Univ Greenland, Nuuk, Greenland..
    Bjertness, Espen
    Univ Oslo, N-0316 Oslo, Norway..
    Bjokelund, Cecilia
    Gothenburg Univ, S-41124 Gothenburg, Sweden..
    Blokstra, Anneke
    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands..
    Bo, Simona
    Univ Turin, I-10124 Turin, Italy..
    Bobak, Martin
    UCL, London WC1E 6BT, England..
    Boeing, Heiner
    German Inst Human Nutr, Nuthetal, Germany..
    Boggia, Jose G.
    Univ Republica, Montevideo, Uruguay..
    Boissonnet, Carlos P.
    CEMIC, Buenos Aires, DF, Argentina..
    Bongard, Vanina
    Toulouse Univ, Sch Med, Toulouse, France..
    Braeckman, Lutgart
    Univ Ghent, B-9000 Ghent, Belgium..
    Brajkovich, Imperia
    Cent Univ Venezuela, Caracas, Venezuela..
    Branca, Francesco
    WHO, Geneva, Switzerland..
    Breckenkamp, Juergen
    Univ Bielefeld, Bielefeld, Germany..
    Brenner, Hermann
    German Canc Res Ctr, Heidelberg, Germany..
    Brewster, Lizzy M.
    Univ Amsterdam, NL-1012 WX Amsterdam, Netherlands..
    Bruno, Graziella
    Univ Turin, I-10124 Turin, Italy..
    Bueno-de-Mesquita, H. B. (as)
    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands..
    Bugge, Anna
    Univ Southern Denmark, Odense, Denmark..
    Burns, Con
    Cork Inst Technol, Cork, Ireland..
    Bursztyn, Michael
    Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel..
    de Leon, Antonio Cabrera
    Univ La Laguna, E-38207 San Cristobal la Laguna, Spain..
    Cameron, Christine
    Canadian Fitness & Lifestyle Res Inst, Ottawa, ON, Canada..
    Can, Gunay
    Istanbul Univ, Istanbul, Turkey..
    Candido, Ana Paula C.
    Univ Fed Juiz de Fora, Juiz De Fora, Brazil..
    Capuano, Vincenzo
    Cardiol Mercato S Severino, Mercato San Severino, Italy..
    Cardoso, Viviane C.
    Univ Sao Paulo, BR-05508 Sao Paulo, Brazil..
    Carlsson, Axel C.
    Karolinska Inst, S-10401 Stockholm, Sweden..
    Carvalho, Maria J.
    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
    Casanueva, Felipe F.
    Santiago de Compostela Univ, Santiago De Compostela, Spain..
    Casas, Juan-Pablo
    UCL, London WC1E 6BT, England..
    Caserta, Carmelo A.
    Assoc Calabrese Epatol, Reggio Di Calabria, Italy..
    Chamukuttan, Snehalatha
    India Diabet Res Fdn, Madras, Tamil Nadu, India..
    Chan, Angelique W.
    Duke NUS Med Sch, Singapore, Singapore..
    Chan, Queenie
    Imperial Coll London, London W2 1PG, England..
    Chaturvedi, Himanshu K.
    Natl Inst Med Stat, Delhi, India..
    Chaturvedi, Nishi
    UCL, London WC1E 6BT, England..
    Chen, Chien-Jen
    Acad Sinica, Taipei, Taiwan..
    Chen, Fangfang
    Capital Inst Pediat, Beijing, Peoples R China..
    Chen, Huashuai
    Duke Univ, Durham, NC 27706 USA..
    Chen, Shuohua
    Kailuan Gen Hosp, Tangshan, Peoples R China..
    Chen, Zhengming
    Univ Oxford, Oxford OX1 2JD, England..
    Cheng, Ching-Yu
    Duke NUS Med Sch, Singapore, Singapore..
    Dekkaki, Imane Cherkaoui
    Univ Mohammed V Rabat, Rabat, Morocco..
    Chetrit, Angela
    Gertner Inst Epidemiol & Hlth Policy Res, Tel Hashomer, Israel..
    Chiolero, Arnaud
    Univ Lausanne Hosp, Lausanne, Switzerland..
    Chiou, Shu-Ti
    Minist Hlth & Welf, Taipei, Taiwan..
    Chirita-Emandi, Adela
    Victor Babes Univ Med & Pharm Timisoara, Timisoara, Romania..
    Cho, Belong
    Seoul Natl Univ, Coll Med, Seoul 151, South Korea..
    Cho, Yumi
    Korea Ctr Dis Control & Prevent, Cheongju, South Korea..
    Chudek, Jerzy
    Med Univ Silesia, Silesia, Poland..
    Cifkova, Renata
    Charles Univ Prague, Prague, Czech Republic..
    Claessens, Frank
    Katholieke Univ Leuven, Leuven, Belgium..
    Clays, Els
    Univ Ghent, B-9000 Ghent, Belgium..
    Concin, Hans
    Agcy Prevent & Social Med, Bregenz, Austria..
    Cooper, Cyrus
    Univ Southampton, Southampton SO9 5NH, Hants, England..
    Cooper, Rachel
    UCL, London WC1E 6BT, England..
    Coppinger, Tara C.
    Cork Inst Technol, Cork, Ireland..
    Costanzo, Simona
    IRCCS Ist Neurol Mediterraneo Neuromed, Pozzilli, Italy..
    Cottel, Dominique
    Inst Pasteur, Lille, France..
    Cowell, Chris
    Westmead Univ Sydney, Sydney, NSW, Australia..
    Craig, Cora L.
    Canadian Fitness & Lifestyle Res Inst, Ottawa, ON, Canada..
    Crujeiras, Ana B.
    CIBEROBN, Madrid, Spain..
    Cruz, Juan J.
    Univ Autonoma Madrid, E-28049 Madrid, Spain..
    D'Arrigo, Graziella
    CNR, Rome, Italy..
    d'Orsi, Eleonora
    Univ Fed Santa Catarina, BR-88040900 Florianopolis, SC, Brazil..
    Dallongeville, Jean
    Inst Pasteur, Lille, France..
    Damasceno, Albertino
    Eduardo Mondlane Univ, Maputo, Mozambique..
    Dankner, Rachel
    Gertner Inst Epidemiol & Hlth Policy Res, Tel Hashomer, Israel..
    Dantoft, Thomas M.
    Res Ctr Prevent & Hlth, Glostrup, Denmark..
    Dauchet, Luc
    Lille Univ & Hosp, Lille, France.;Univ Lausanne Hosp, Lausanne, Switzerland..
    De Backer, Guy
    Univ Ghent, B-9000 Ghent, Belgium..
    de Gaetano, Giovanni
    IRCCS Ist Neurol Mediterraneo Neuromed, Pozzilli, Italy..
    De Henauw, Stefaan
    Univ Ghent, B-9000 Ghent, Belgium..
    De Smedt, Delphine
    Univ Ghent, B-9000 Ghent, Belgium..
    Deepa, Mohan
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India..
    Dehghan, Abbas
    Harvard TH Chan Sch Publ Hlth, Boston, MA USA.;Karolinska Inst, S-10401 Stockholm, Sweden.;Erasmus MC, Rotterdam, Netherlands.;Inst Trop Med, Antwerp, Belgium.;Amrita Inst Med Sci, Ernakulam, Kerala, India.;Univ Ctr Occidental Lisandro Alvarado, Lara, Venezuela.;St Vincents Hosp, Darlinghurst, NSW, Australia..
    Delisle, Helene
    Univ Montreal, Montreal, PQ H3C 3J7, Canada..
    Deschamps, Valerie
    French Publ Hlth Agcy, St Maurice, France..
    Dhana, Klodian
    Erasmus MC, Rotterdam, Netherlands..
    Di Castelnuovo, Augusto F.
    IRCCS Ist Neurol Mediterraneo Neuromed, Pozzilli, Italy..
    Dias-da-Costa, Juvenal Soares
    Univ Vale Rio dos Sinos, Sao Leopoldo, RS, Brazil..
    Diaz, Alejandro
    Natl Council Sci & Tech Res, Buenos Aires, DF, Argentina..
    Dickerson, Ty T.
    Univ Utah, Sch Med, Salt Lake City, UT 84112 USA..
    Do, Ha T. P.
    Natl Inst Nutr, Hanoi, Vietnam..
    Dobson, Annette J.
    Univ Queensland, Brisbane, Qld 4072, Australia..
    Donfrancesco, Chiara
    Ist Super Sanita, Rome, Italy..
    Donoso, Silvana P.
    Univ Cuenca, Cuenca, Ecuador..
    Doering, Angela
    Helmholtz Zentrum Munchen, Oberschleissheim, Germany..
    Doua, Kouamelan
    Minist Sante & Lutte Sida, Abidjan Plateau, Cote Ivoire..
    Drygas, Wojciech
    Cardinal Wyszynski Inst Cardiol, Warsaw, Poland..
    Dulskiene, Virginija
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania..
    Dzakula, Aleksandar
    Univ Zagreb, Zagreb 41000, Croatia..
    Dzerve, Vilnis
    Univ Latvia, Riga, Latvia..
    Dziankowska-Zaborszczyk, Elzbieta
    Med Univ Lodz, Lodz, Poland..
    Eggertsen, Robert
    Gothenburg Univ, S-41124 Gothenburg, Sweden..
    Ekelund, Ulf
    Norwegian Sch Sport Sci, Oslo, Norway..
    El Ati, Jalila
    Natl Inst Nutr & Food Technol, Tunis, Tunisia..
    Ellert, Ute
    Robert Koch Inst, Berlin, Germany..
    Elosua, Roberto
    Inst Hosp Invest Med, Barcelona, Spain..
    Erasmus, Rajiv T.
    Univ Stellenbosch, ZA-7600 Stellenbosch, South Africa..
    Erem, Cihangir
    Karadeniz Tech Univ, Trabzon, Turkey..
    Eriksen, Louise
    Univ Southern Denmark, Odense, Denmark..
    Escobedo-de la Pena, Jorge
    Inst Mexicano Seguro Social, Mexico City, DF, Mexico..
    Evans, Alun
    Queens Univ Belfast, Belfast BT7 1NN, Antrim, North Ireland..
    Faeh, David
    Univ Zurich, CH-8006 Zurich, Switzerland..
    Fall, Caroline H.
    Univ Southampton, Southampton SO9 5NH, Hants, England..
    Farzadfar, Farshad
    Univ Tehran Med Sci, Tehran, Iran..
    Felix-Redondo, Francisco J.
    Ctr Salud Villanueva Norte, Villanueva De La Serena, Spain..
    Ferguson, Trevor S.
    Univ West Indies, Kingston, Jamaica..
    Fernandez-Berges, Daniel
    Hosp Don Benito Villanueva Serena, Badajoz, Spain..
    Ferrante, Daniel
    Minist Hlth, Buenos Aires, DF, Argentina..
    Ferrari, Marika
    Council Agr Res & Econ, Arezzo, Italy..
    Ferreccio, Catterina
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Ferrieres, Jean
    Toulouse Univ, Sch Med, Toulouse, France..
    Finn, Joseph D.
    Univ Manchester, Manchester M13 9PL, Lancs, England..
    Fischer, Krista
    Univ Tartu, Tartu, Estonia..
    Foeger, Bernhard
    Agcy Prevent & Social Med, Bregenz, Austria..
    Foo, Leng Huat
    Univ Sains Malaysia, George Town, Malaysia..
    Forslund, Ann-Sofie
    Umea Univ, S-90187 Umea, Sweden..
    Forsner, Maria
    Dalarna Univ, Falun, Sweden..
    Fortmann, Stephen P.
    Stanford Univ, Stanford, CA 94305 USA..
    Fouad, Heba M.
    WHO, Reg Off Eastern Mediterranean, Cairo, Egypt..
    Francis, Damian K.
    Univ West Indies, Kingston, Jamaica..
    Franco, Maria do Carmo
    Univ Fed Sao Paulo, Sao Paulo, Brazil..
    Franco, Oscar H.
    Erasmus MC, Rotterdam, Netherlands..
    Frontera, Guillermo
    Hosp Univ Son Espases, Palma De Mallorca, Spain..
    Fuchs, Flavio D.
    Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil..
    Fuchs, Sandra C.
    Univ Fed Rio Grande do Sul, BR-90046900 Porto Alegre, RS, Brazil..
    Fujita, Yuki
    Kindai Univ, Higashiosaka, Osaka, Japan..
    Furusawa, Takuro
    Kyoto Univ, Kyoto 6068501, Japan..
    Gaciong, Zbigniew
    Med Univ Warsaw, Warsaw, Poland..
    Gareta, Dickman
    Univ KwaZulu Natal, Durban, South Africa..
    Garnett, Sarah P.
    Univ Sydney, Sydney, NSW 2006, Australia..
    Gaspoz, Jean-Michel
    Univ Hosp Geneva, Geneva, Switzerland..
    Gasull, Magda
    CIBER Epidemiol & Salud Publ, Madrid, Spain..
    Gates, Louise
    Australian Bur Stat, Belconnen, ACT, Australia..
    Gavrila, Diana
    Murcia Reg Hlth Council, Murcia, Spain..
    Geleijnse, Johanna M.
    Wageningen Univ, NL-6700 AP Wageningen, Netherlands..
    Ghasemian, Anoosheh
    Wageningen Univ, NL-6700 AP Wageningen, Netherlands.;Endocrinol & Metab Res Inst, Tehran, Iran..
    Ghimire, Anup
    BP Koirala Inst Hlth Sci, Dharan, Nepal..
    Giampaoli, Simona
    Ist Super Sanita, Rome, Italy..
    Gianfagna, Francesco
    Univ Insubria, Varese, Italy..
    Giovannelli, Jonathan
    Lille Univ & Hosp, Lille, France..
    Goldsmith, Rebecca A.
    Minist Hlth, Jerusalem, Israel..
    Goncalves, Helen
    Univ Fed Pelotas, Pelotas, RS, Brazil..
    Gonzalez Gross, Marcela
    Univ Autonoma Madrid, E-28049 Madrid, Spain..
    Gonzalez Rivas, Juan P.
    Andes Clin Cardiometab Studies, Timotes, Venezuela..
    Gottrand, Frederic
    Univ Lille 2, F-59800 Lille, France..
    Graff-Iversen, Sidsel
    Norwegian Inst Publ Hlth, Oslo, Norway..
    Grafnetter, Dusan
    Inst Clin & Expt Med, Prague, Czech Republic..
    Grajda, Aneta
    Childrens Mem Hlth Inst, Warsaw, Poland..
    Gregor, Ronald D.
    Dalhousie Univ, Halifax, NS B3H 3J5, Canada..
    Grodzicki, Tomasz
    Jagiellonian Univ, Coll Med, PL-31007 Krakow, Poland..
    Grontved, Anders
    Univ Southern Denmark, Odense, Denmark..
    Gruden, Grabriella
    Univ Turin, I-10124 Turin, Italy..
    Grujic, Vera
    Univ Novi Sad, Novi Sad 21000, Serbia..
    Guan, Ong Peng
    Singapore Eye Res Inst, Singapore, Singapore..
    Gudnason, Vilmundur
    Univ Iceland, IS-101 Reykjavik, Iceland..
    Guerrero, Ramiro
    Univ Icesi, Cali, Colombia..
    Guessous, Idris
    Univ Hosp Geneva, Geneva, Switzerland..
    Guimaraes, Andre L.
    Univ Estadual Montes Claros, Montes Claros, Brazil..
    Gulliford, Martin C.
    Kings Coll London, London WC2R 2LS, England..
    Gunnlaugsdottir, Johanna
    Iceland Heart Assoc, Kopavogur, Iceland..
    Gunter, Marc
    Imperial Coll London, London W2 1PG, England..
    Gupta, Prakash C.
    Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, India..
    Gureje, Oye
    Univ Ibadan, Ibadan, Nigeria..
    Gurzkowska, Beata
    Childrens Mem Hlth Inst, Warsaw, Poland..
    Gutierrez, Laura
    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina..
    Gutzwiller, Felix
    Univ Zurich, CH-8006 Zurich, Switzerland..
    Hadaegh, Farzad
    Shahid Beheshti Univ Med Sci, Tehran, Iran..
    Halkjaer, Jytte
    Danish Canc Soc, Res Ctr, Copenhagen, Denmark..
    Hambleton, Ian R.
    Univ West Indies, Wanstead, Barbados..
    Hardy, Rebecca
    UCL, London WC1E 6BT, England..
    Harikumar, Rachakulla
    Natl Inst Nutr, Hyderabad, Andhra Pradesh, India..
    Hata, Jun
    Kyushu Univ, Fukuoka 812, Japan..
    Hayes, Alison J.
    Univ Sydney, Sydney, NSW 2006, Australia..
    He, Jiang
    Tulane Univ, New Orleans, LA 70118 USA..
    Hendriks, Marleen Elisabeth
    Acad Med Ctr Amsterdam, Amsterdam, Netherlands..
    Henriques, Ana
    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
    Hernandez Cadena, Leticia
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Herqutanto,
    Herrala, Sauli
    Oulu Univ Hosp, Oulu, Finland..
    Heshmat, Ramin
    Chron Dis Res Ctr, Tehran, Iran..
    Hihtaniemi, Ilpo Tapani
    Imperial Coll London, London W2 1PG, England..
    Ho, Sai Yin
    Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China..
    Ho, Suzanne C.
    Chinese Univ Hong Kong, ```, Hong Kong, Hong Kong, Peoples R China..
    Hobbs, Michael
    Univ Western Australia, Nedlands, WA 6009, Australia..
    Hofman, Albert
    Erasmus MC, Rotterdam, Netherlands..
    Dinc, Gonul Horasan
    Celal Bayar Univ, Manisa, Turkey..
    Hormiga, Claudia M.
    Fdn Oftalmol Santander, Floridablanca, Santander, Spain..
    Horta, Bernardo L.
    Univ Fed Pelotas, Pelotas, RS, Brazil..
    Houti, Leila
    Univ Oran 1, Oran, Algeria..
    Howitt, Christina
    Univ West Indies, Wanstead, Barbados..
    Htay, Thein Thein
    Univ Publ Hlth, Yangon, Myanmar..
    Htet, Aung Soe
    Minist Hlth, Naypyitaw, Myanmar..
    Hu, Yonghua
    Peking Univ, Beijing, Peoples R China..
    Maria Huerta, Jose
    CIBER Epidemiol & Salud Publ, Madrid, Spain..
    Husseini, Abdullatif S.
    Birzeit Univ, Birzeit, Israel..
    Huybrechts, Inge
    Int Agcy Res Canc, Lyon, France..
    Hwalla, Nahla
    Amer Univ Beirut, Beirut, Lebanon..
    Iacoviello, Licia
    IRCCS Ist Neurol Mediterraneo Neuromed, Pozzilli, Italy..
    Iannone, Anna G.
    Cardiol Mercato S Severino, Mercato San Severino, Italy..
    Ibrahim, M. Mohsen
    Cairo Univ, Giza, Egypt..
    Ikram, M. Arfan
    Erasmus MC, Rotterdam, Netherlands..
    Irazola, Vilma E.
    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina..
    Islam, Muhammad
    Aga Khan Univ, Karachi, Pakistan..
    Ivkovic, Vanja
    UHC Zagreb, Zagreb, Croatia..
    Iwasaki, Masanori
    Niigata Univ, Niigata, Japan..
    Jacobs, Jeremy M.
    Hadassah Univ, Med Ctr, Jerusalem, Israel..
    Jafar, Tazeen
    Duke NUS Med Sch, Singapore, Singapore..
    Jamrozik, Konrad
    Univ Adelaide, Adelaide, SA 5005, Australia..
    Janszky, Imre
    Norwegian Univ Sci & Technol, Trondheim, Norway..
    Jasienska, Grazyna
    Jagiellonian Univ, Coll Med, PL-31007 Krakow, Poland..
    Jelakovic, Bojan
    Univ Zagreb, Sch Med, Zagreb 41000, Croatia..
    Jiang, Chao Qiang
    Guangzhou 12th Hosp, Guangzhou, Guangdong, Peoples R China..
    Johansson, Mattias
    Int Agcy Res Canc, Lyon, France..
    Jonas, Jost B.
    Heidelberg Univ, Heidelberg, Germany..
    Jorgensen, Torben
    Res Ctr Prevent & Hlth, Glostrup, Denmark..
    Joshi, Pradeep
    WHO, Country Off, New Delhi, India..
    Juolevi, Anne
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Jurak, Gregor
    Univ Ljubljana, Ljubljana 61000, Slovenia..
    Juresa, Vesna
    Univ Zagreb, Zagreb 41000, Croatia..
    Kaaks, Rudolf
    German Canc Res Ctr, Heidelberg, Germany..
    Kafatos, Anthony
    Univ Crete, Iraklion, Greece..
    Kalter-Leibovici, Ofra
    Gertner Inst Epidemiol & Hlth Policy Res, Tel Hashomer, Israel..
    Kamaruddin, Nor Azmi
    Univ Kebangsaan Malaysia, Bangi 43600, Malaysia..
    Kasaeian, Amir
    Univ Tehran Med Sci, Tehran, Iran..
    Katz, Joanne
    Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA..
    Kauhanen, Jussi
    Univ Eastern Finland, Joensuu, Finland..
    Kaur, Prabhdeep
    Natl Inst Epidemiol, Madras, Tamil Nadu, India..
    Kavousi, Maryam
    Erasmus MC, Rotterdam, Netherlands..
    Kazakbaeva, Gyulli
    Ufa Eye Res Inst, Ufa, Russia..
    Keil, Ulrich
    Univ Munster, Munster, Germany..
    Boker, Lital Keinan
    Israel Ctr Dis Control, Jerusalem, Israel..
    Keinanen-Kiukaanniemi, Sirkka
    Oulu Univ Hosp, Oulu, Finland..
    Kelishadi, Roya
    Res Inst Primordial Prevent Noncommunicable Dis, Esfahan, Iran..
    Kemper, Han C. G.
    Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands..
    Kersting, Mathilde
    Res Inst Child Nutr, Dortmund, Germany..
    Key, Timothy
    Univ Oxford, Oxford OX1 2JD, England..
    Khader, Yousef Saleh
    Jordan Univ Sci & Technol, Irbid, Jordan..
    Khalili, Davood
    Shahid Beheshti Univ Med Sci, Tehran, Iran..
    Khang, Young-Ho
    Seoul Natl Univ, Seoul 151, South Korea..
    Khaw, Kay-Tee
    Univ Cambridge, Cambridge CB2 1TN, England..
    Kiechl, Stefan
    Med Univ Innsbruck, Innsbruck, Austria..
    Killewo, Japhet
    Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania..
    Kim, Jeongseon
    Natl Canc Ctr, Goyang Si, South Korea..
    Klumbiene, Jurate
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania..
    Kolle, Elin
    Norwegian Sch Sport Sci, Oslo, Norway..
    Kolsteren, Patrick
    Inst Trop Med, Antwerp, Belgium..
    Korrovits, Paul
    Tartu Univ Clin, Tartu, Estonia..
    Koskinen, Seppo
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Kouda, Katsuyasu
    Kindai Univ, Higashiosaka, Osaka, Japan..
    Koziel, Slawomir
    Polish Acad Sci, Anthropol Unit, Warsaw, Poland..
    Kristensen, Peter Lund
    Univ Southern Denmark, Odense, Denmark..
    Krokstad, Steinar
    Norwegian Univ Sci & Technol, Trondheim, Norway..
    Kromhout, Daan
    Univ Groningen, NL-9700 AB Groningen, Netherlands..
    Kruger, Herculina S.
    North West Univ, Potchefstroom, South Africa..
    Kubinova, Ruzena
    Natl Inst Publ Hlth, Prague, Czech Republic..
    Kuciene, Renata
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania..
    Kuh, Diana
    UCL, London WC1E 6BT, England..
    Kujala, Urho M.
    Univ Jyvaskyla, SF-40351 Jyvaskyla, Finland..
    Kula, Krzysztof
    Med Univ Lodz, Lodz, Poland..
    Kulaga, Zbigniew
    Childrens Mem Hlth Inst, Warsaw, Poland..
    Kumar, R. Krishna
    Amrita Inst Med Sci, Ernakulam, Kerala, India..
    Kurjata, Pawel
    Cardinal Wyszynski Inst Cardiol, Warsaw, Poland..
    Kusuma, Yadlapalli S.
    All India Inst Med Sci, New Delhi, India..
    Kuulasmaa, Kari
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Kyobutungi, Catherine
    African Populat & Hlth Res Ctr, Nairobi, Kenya..
    Lachat, Carl
    Univ Ghent, B-9000 Ghent, Belgium..
    Landrove, Orlando
    Minist Salud Publ, Havana, Cuba..
    Lanska, Vera
    Inst Clin & Expt Med, Prague, Czech Republic..
    Lappas, Georg
    Sahlgrens Acad, Gothenburg, Sweden..
    Larijani, Bagher
    Endocrinol & Metab Res Inst, Tehran, Iran..
    Laugsand, Lars E.
    Norwegian Univ Sci & Technol, Trondheim, Norway..
    Bao, Khanh Le Nguyen
    Le, Tuyen D.
    Natl Inst Nutr, Hanoi, Vietnam..
    Leclercq, Catherine
    Food & Agr Org, Rome, Italy..
    Lee, Jeannette
    Natl Univ Singapore, Singapore, Singapore..
    Lee, Jeonghee
    Natl Canc Ctr, Goyang Si, South Korea..
    Lehtimaki, Terho
    Tampere Univ Hosp, Tampere, Finland..
    Lekhraj, Rampal
    Univ Putra Malaysia, Serdang 43400, Malaysia..
    Leon-Munoz, Luz M.
    Univ Autonoma Madrid, E-28049 Madrid, Spain..
    Levitt, Naomi S.
    Univ Cape Town, ZA-7700 Rondebosch, South Africa..
    Li, Yanping
    Harvard TH Chan Sch Publ Hlth, Boston, MA USA..
    Lilly, Christa L.
    W Virginia Univ, Morgantown, WV 26506 USA..
    Lim, Wei-Yen
    Natl Univ Singapore, Singapore, Singapore..
    Fernanda Lima-Costa, M.
    Fundacao Oswaldo Cruz, Rene Rachou Res Inst, Rio De Janeiro, Brazil.;Univ Philippines, Quezon City 1101, Philippines..
    Lin, Hsien-Ho
    Natl Taiwan Univ, Taipei, Taiwan..
    Lin, Xu
    Univ Chinese Acad Sci, Beijing, Peoples R China..
    Linneberg, Allan
    Res Ctr Prevent & Hlth, Glostrup, Denmark..
    Lissner, Lauren
    Gothenburg Univ, S-41124 Gothenburg, Sweden..
    Litwin, Mieczyslaw
    Childrens Mem Hlth Inst, Warsaw, Poland..
    Lorbeer, Roberto
    Univ Med Greifswald, Greifswald, Germany..
    Lotufo, Paulo A.
    Univ Sao Paulo, BR-05508 Sao Paulo, Brazil..
    Eugenio Lozano, Jose
    Consejeria Sanidad Junta de Castilla & Leon, Valladolid, Spain..
    Luksiene, Dalia
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania..
    Lundqvist, Annamari
    Lunet, Nuno
    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
    Lytsy, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Ma, Guansheng
    Peking Univ, Beijing, Peoples R China..
    Ma, Jun
    Peking Univ, Beijing, Peoples R China..
    Machado-Coelho, George L. L.
    Univ Fed Ouro Preto, Ouro Preto, MG, Brazil..
    Machi, Suka
    Jikei Univ, Sch Med, Tokyo, Japan..
    Maggi, Stefania
    CNR, Rome, Italy..
    Magliano, Dianna J.
    Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia..
    Majer, Marjeta
    Univ Zagreb, Zagreb 41000, Croatia..
    Makdisse, Marcia
    Hosp Israelita Albert Einstein, Sao Paulo, Brazil..
    Malekzadeh, Reza
    Univ Tehran Med Sci, Tehran, Iran..
    Malhotra, Rahul
    Duke NUS Med Sch, Singapore, Singapore..
    Rao, Kodavanti Mallikharjuna
    Natl Inst Nutr, Hyderabad, Andhra Pradesh, India..
    Malyutina, Sofia
    Inst Internal & Prevent Med, Novosibirsk, Russia..
    Manios, Yannis
    Harokopio Univ, Kallithea, Greece..
    Mann, Jim I.
    Univ Otago, Dunedin, New Zealand..
    Manzato, Enzo
    Univ Padua, I-35100 Padua, Italy..
    Margozzini, Paula
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Marques-Vidal, Pedro
    Univ Lausanne Hosp, Lausanne, Switzerland..
    Marrugat, Jaume
    Natl Inst Hlth & Welf, Helsinki, Finland.;Inst Hosp Invest Med, Barcelona, Spain..
    Martorell, Reynaldo
    Emory Univ, Atlanta, GA 30322 USA..
    Mathiesen, Ellisiv B.
    UiT Arctic Univ Norway, Tromso, Norway..
    Matijasevich, Alicia
    Univ Sao Paulo, BR-05508 Sao Paulo, Brazil..
    Matsha, Tandi E.
    Cape Peninsula Univ Technol, Cape Town, South Africa..
    Mbanya, Jean Claude N.
    Univ Yaounde I, Yaounde, Cameroon..
    Posso, Anselmo J. Mc Donald
    Gorgas Mem Inst Hlth Studies, Panama City, Panama..
    McFarlane, Shelly R.
    Univ West Indies, Kingston, Jamaica..
    McGarvey, Stephen T.
    Brown Univ, Providence, RI 02912 USA..
    McLachlan, Stela
    Univ Edinburgh, Edinburgh EH8 9YL, Midlothian, Scotland..
    McLean, Rachael M.
    Univ Otago, Dunedin, New Zealand..
    McNulty, Breige A.
    Univ Coll Dublin, Dublin, Ireland..
    Khir, Amir Sharifuddin Md
    Penang Med Coll, George Town, Malaysia..
    Mediene-Benchekor, Sounnia
    Univ Oran 1, Oran, Algeria..
    Medzioniene, Jurate
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania..
    Meirhaeghe, Aline
    INSERM, F-75654 Paris 13, France..
    Meisinger, Christa
    Helmholtz Zentrum Munchen, Oberschleissheim, Germany..
    Menezes, Ana Maria B.
    Univ Fed Pelotas, Pelotas, RS, Brazil..
    Menon, Geetha R.
    Indian Council Med Res, New Delhi, India..
    Meshram, Indrapal I.
    Natl Inst Nutr, Hyderabad, Andhra Pradesh, India..
    Metspalu, Andres
    Univ Tartu, Tartu, Estonia..
    Mi, Jie
    Capital Inst Pediat, Beijing, Peoples R China..
    Mikkel, Kairit
    Univ Tartu, Tartu, Estonia..
    Miller, Jody C.
    Univ Otago, Dunedin, New Zealand..
    Francisco Miquel, Juan
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Jaime Miranda, J.
    Univ Peruana Cayetano Heredia, Lima, Peru..
    Misigoj-Durakovic, Marjeta
    Univ Zagreb, Zagreb 41000, Croatia..
    Mohamed, Mostafa K.
    Ain Shams Univ, Cairo, Egypt..
    Mohammad, Kazem
    Univ Tehran Med Sci, Tehran, Iran..
    Mohammadifard, Noushin
    Hypertens Res Ctr, Esfahan, Iran..
    Mohan, Viswanathan
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India..
    Yusoff, Muhammad Fadhli Mohd
    Minist Hlth Malaysia, Putrajaya, Malaysia.;Inst Med Res, Kuala Lumpur, Malaysia.;Minist Hlth, Putrajaya, Malaysia..
    Moller, Niels C.
    Univ Southern Denmark, Odense, Denmark..
    Molnar, Denes
    Univ Pecs, Pecs, Hungary..
    Momenan, Amirabbas
    Shahid Beheshti Univ Med Sci, Tehran, Iran..
    Monyeki, Kotsedi Daniel K.
    Univ Limpopo, Polokwane, South Korea..
    Moreira, Leila B.
    Univ Fed Rio Grande do Sul, BR-90046900 Porto Alegre, RS, Brazil..
    Morejon, Alain
    Moreno, Luis A.
    Univ Zaragoza, E-50009 Zaragoza, Spain..
    Morgan, Karen
    RCSI Dublin, Dublin, Ireland..
    Moschonis, George
    Harokopio Univ, Kallithea, Greece..
    Mossakowska, Malgorzata
    Int Inst Mol & Cell Biol, Warsaw, Poland..
    Mostafa, Aya
    Ain Shams Univ, Cairo, Egypt..
    Mota, Jorge
    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
    Motlagh, Mohammad Esmaeel
    Ahvaz Jundishapur Univ Med Sci, Ahwaz, Iran..
    Motta, Jorge
    Gorgas Mem Inst Hlth Studies, Panama City, Panama..
    Muiesan, Maria L.
    Univ Brescia, I-25121 Brescia, Italy..
    Mueller-Nurasyid, Martina
    Murphy, Neil
    Imperial Coll London, London W2 1PG, England..
    Mursu, Jaakko
    Univ Eastern Finland, Joensuu, Finland..
    Musil, Vera
    Univ Zagreb, Zagreb 41000, Croatia..
    Nagel, Gabriele
    Univ Ulm, D-89069 Ulm, Germany..
    Naidu, Balkish M.
    Inst Publ Hlth, Kuala Lumpur, Malaysia..
    Nakamura, Harunobu
    Kobe Univ, Kobe, Hyogo, Japan..
    Namsna, Jana
    Reg Author Publ Hlth, Banska Bystrica, Slovakia..
    Nang, Ei Ei K.
    Natl Univ Singapore, Singapore, Singapore..
    Nangia, Vinay B.
    Suraj Eye Inst, Nagpur, Maharashtra, India..
    Narake, Sameer
    Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, India..
    Maria Navarrete-Munoz, Eva
    CIBER Epidemiol & Salud Publ, Madrid, Spain..
    Ndiaye, Ndeye Coumba
    INSERM, F-75654 Paris 13, France..
    Neal, William A.
    W Virginia Univ, Morgantown, WV 26506 USA..
    Nenko, Ilona
    Jagiellonian Univ, Coll Med, PL-31007 Krakow, Poland..
    Nervi, Flavio
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Nguyen, Nguyen D.
    Univ Pharm & Med Ho Chi Minh City, Ho Chi Minh City, Vietnam..
    Nguyen, Quang Ngoc
    Nieto-Martinez, Ramfis E.
    Univ Ctr Occidental Lisandro Alvarado, Lara, Venezuela..
    Niiranen, Teemu J.
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Ning, Guang
    Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China..
    Ninomiya, Toshiharu
    Kyushu Univ, Fukuoka 812, Japan..
    Nishtar, Sania
    Heartfile, Islamabad, Pakistan..
    Noale, Marianna
    CNR, Rome, Italy..
    Noboa, Oscar A.
    Univ Republica, Montevideo, Uruguay..
    Noorbala, Ahmad Ali
    Univ Tehran Med Sci, Tehran, Iran..
    Norat, Teresa
    Imperial Coll London, London W2 1PG, England..
    Noto, Davide
    Univ Palermo, I-90133 Palermo, Italy..
    Al Nsour, Mohannad
    Eastern Mediterranean Publ Hlth Network, Amman, Jordan..
    O'Reilly, Dermot
    Queens Univ Belfast, Belfast BT7 1NN, Antrim, North Ireland..
    Oh, Kyungwon
    Korea Ctr Dis Control & Prevent, Cheongju, South Korea..
    Olinto, Maria Teresa A.
    Univ Vale Rio dos Sinos, Sao Leopoldo, RS, Brazil..
    Oliveira, Isabel O.
    Univ Fed Pelotas, Pelotas, RS, Brazil..
    Omar, Mohd Azahadi
    Minist Hlth Malaysia, Putrajaya, Malaysia..
    Onat, Altan
    Istanbul Univ, Istanbul, Turkey..
    Ordunez, Pedro
    Pan Amer Hlth Org, Washington, DC USA..
    Osmond, Clive
    Ostojic, Sergej M.
    Univ Novi Sad, Novi Sad 21000, Serbia..
    Otero, Johanna A.
    Fdn Oftalmol Santander, Floridablanca, Santander, Spain..
    Overvad, Kim
    Aarhus Univ, DK-8000 Aarhus C, Denmark..
    Owusu-Dabo, Ellis
    Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana..
    Paccaud, Fred Michel
    Inst Social & Prevent Med, Bern, Switzerland..
    Padez, Cristina
    Univ Coimbra, P-3000 Coimbra, Portugal..
    Pahomova, Elena
    Univ Latvia, Riga, Latvia..
    Pajak, Andrzej
    Jagiellonian Univ, Coll Med, PL-31007 Krakow, Poland..
    Palli, Domenico
    Canc Prevent & Res Inst, Genoa, Italy..
    Palmieri, Luigi
    Ist Super Sanita, Rome, Italy..
    Panda-Jonas, Songhomitra
    Heidelberg Univ, Heidelberg, Germany..
    Panza, Francesco
    Univ Bari, I-70121 Bari, Italy..
    Papandreou, Dimitrios
    Zayed Univ, Dubai, U Arab Emirates..
    Parnell, Winsome R.
    Univ Otago, Dunedin, New Zealand..
    Parsaeian, Mahboubeh
    Univ Tehran Med Sci, Tehran, Iran..
    Pecin, Ivan
    Univ Zagreb, Sch Med, Zagreb 41000, Croatia..
    Pednekar, Mangesh S.
    Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, India..
    Peer, Nasheeta
    South African Med Res Council, Cape Town, South Africa..
    Peeters, Petra H.
    Univ Med Ctr Utrecht, Utrecht, Netherlands..
    Peixoto, Sergio Viana
    Fundacao Oswaldo Cruz, Rene Rachou Res Inst, Rio De Janeiro, Brazil..
    Pelletier, Catherine
    Publ Hlth Agcy Canada, Ottawa, ON, Canada..
    Peltonen, Markku
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Pereira, Alexandre C.
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    Helmholtz Zentrum Munchen, Oberschleissheim, Germany..
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    Leibniz Institute for Prevention Research and Epi, Bremen, Germany..
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    UCL, London WC1E 6BT, England..
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    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina..
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    Univ Madeira, Funchal, Portugal..
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    Inst Mexicano Seguro Social, Mexico City, DF, Mexico..
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    Singapore Eye Res Inst, Singapore, Singapore..
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    Univ Tunis El Manar, Tunis, Tunisia..
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    Marmara Univ, Istanbul, Turkey..
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    French Publ Hlth Agcy, St Maurice, France..
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    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
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    CIBER Epidemiol & Salud Publ, Madrid, Spain..
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    Natl Inst Hlth & Welf, Helsinki, Finland..
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    Univ Helsinki, FIN-00014 Helsinki, Finland..
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    Univ Brescia, I-25121 Brescia, Italy..
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    Natl Inst Hlth, Lima, Peru..
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    Catalan Dept Hlth, Barcelona, Spain..
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    Univ Lisbon, Lisbon, Portugal..
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    Univ Fed Pelotas, Pelotas, RS, Brazil..
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    Univ Sao Paulo, Clin Hosp, BR-05508 Sao Paulo, Brazil..
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    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
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    S Karelia Social & Hlth Care Dist, Lappeenranta, Finland..
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    Robert Koch Inst, Berlin, Germany..
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    Isfahan Cardiovasc Res Ctr, Esfahan, Iran..
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    German Canc Res Ctr, Heidelberg, Germany..
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    Res & Educ Inst Child Hlth, Nicosia, Cyprus..
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    Univ Sao Paulo, Clin Hosp, BR-05508 Sao Paulo, Brazil..
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    Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina..
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    Univ Fed Santa Catarina, BR-88040900 Florianopolis, SC, Brazil..
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    Acad Med Ctr Amsterdam, Amsterdam, Netherlands..
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    South African Med Res Council, Cape Town, South Africa.;North West Univ, Potchefstroom, South Africa..
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    Norwegian Univ Sci & Technol, Trondheim, Norway..
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    Lagos State Univ, Coll Med, Lagos, Nigeria..
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    Digest Dis Res Inst, Tehran, Iran..
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    BP Koirala Inst Hlth Sci, Dharan, Nepal..
    Shaw, Jonathan E.
    Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia..
    Shibuya, Kenji
    Univ Tokyo, Tokyo 1138654, Japan..
    Shin, Dong Wook
    Seoul Natl Univ, Coll Med, Seoul 151, South Korea..
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    Singapore Eye Res Inst, Singapore, Singapore..
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    Singapore Eye Res Inst, Singapore, Singapore..
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    Amer Univ Beirut, Beirut, Lebanon..
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    Univ Fed Santa Catarina, BR-88040900 Florianopolis, SC, Brazil..
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    India Diabet Res Fdn, Madras, Tamil Nadu, India..
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    St Vincents Hosp, Darlinghurst, NSW, Australia..
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    Univ New South Wales, Sydney, NSW 2052, Australia..
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    Karolinska Inst, S-10401 Stockholm, Sweden..
    Skovbjerg, Sine
    Res Ctr Prevent & Hlth, Glostrup, Denmark..
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    Med Univ Lodz, Lodz, Poland..
    Slusarczyk, Przemyslaw
    Int Inst Mol & Cell Biol, Warsaw, Poland..
    Smith, Margaret C.
    Univ Oxford, Oxford OX1 2JD, England..
    Snijder, Marieke B.
    Acad Med Ctr Amsterdam, Amsterdam, Netherlands..
    So, Hung-Kwan
    Chinese Univ Hong Kong, ```, Hong Kong, Hong Kong, Peoples R China..
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    Univ Yaounde I, Yaounde, Cameroon..
    Soderberg, Stefan
    Umea Univ, S-90187 Umea, Sweden..
    Solfrizzi, Vincenzo
    Univ Bari, I-70121 Bari, Italy..
    Sonestedt, Emily
    Lund Univ, S-22100 Lund, Sweden..
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    Peking Univ, Beijing, Peoples R China..
    Sorensen, Thorkild I. A.
    Univ Copenhagen, DK-1168 Copenhagen, Denmark..
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    Inst Reg Sante Publ, Ouidah, Benin..
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    Univ Bordeaux, Bordeaux, France..
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    Univ Leuven, Leuven, Belgium..
    Starc, Gregor
    Univ Ljubljana, Ljubljana 61000, Slovenia..
    Stathopoulou, Maria G.
    INSERM, F-75654 Paris 13, France..
    Stavreski, Bill
    Heart Fdn, Melbourne, Vic, Australia..
    Steene-Johannessen, Jostein
    Norwegian Sch Sport Sci, Oslo, Norway..
    Stehle, Peter
    Univ Bonn, Bonn, Germany..
    Stein, Aryeh D.
    Emory Univ, Atlanta, GA 30322 USA..
    Stergiou, George S.
    Sotiria Hosp, Athens, Greece..
    Stessman, Jochanan
    Hadassah Univ, Med Ctr, Jerusalem, Israel..
    Stieber, Jutta
    Helmholtz Zentrum Munchen, Oberschleissheim, Germany..
    Stoeckl, Doris
    Helmholtz Zentrum Munchen, Oberschleissheim, Germany..
    Stocks, Tanja
    Lund Univ, S-22100 Lund, Sweden..
    Stokwiszewski, Jakub
    Natl Inst Publ Health, Natl Inst Hyg, Warsaw, Poland..
    Stronks, Karien
    Univ Amsterdam, NL-1012 WX Amsterdam, Netherlands..
    Strufaldi, Maria Wany
    Univ Fed Sao Paulo, Sao Paulo, Brazil..
    Sun, Chien-An
    Fu Jen Catholic Univ, New Taipei, Taiwan..
    Sung, Yn-Tz
    Chinese Univ Hong Kong, ```, Hong Kong, Hong Kong, Peoples R China..
    Suriyawongpaisal, Paibul
    Mahidol Univ, Salaya, Thailand..
    Sy, Rody G.
    Univ Philippines, Quezon City 1101, Philippines..
    Tai, E. Shyong
    Natl Univ Singapore, Singapore, Singapore..
    Tammesoo, Mari-Liis
    Univ Tartu, Tartu, Estonia..
    Tamosiunas, Abdonas
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania.;Karolinska Inst, S-10401 Stockholm, Sweden..
    Tang, Line
    Res Ctr Prevent & Hlth, Glostrup, Denmark..
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    Peking Univ, Beijing, Peoples R China..
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    Univ KwaZulu Natal, Durban, South Africa..
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    Peking Univ, Beijing, Peoples R China..
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    Minist Hlth, Amman, Jordan..
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    Natl Inst Hlth, Lima, Peru..
    Taylor, Anne
    Univ Adelaide, Adelaide, SA 5005, Australia..
    Theobald, Holger
    Karolinska Inst, S-10401 Stockholm, Sweden..
    Thijs, Lutgarde
    Univ Leuven, Leuven, Belgium..
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    Res Ctr Prevent & Hlth, Glostrup, Denmark..
    Tjonneland, Anne
    Danish Canc Soc, Res Ctr, Copenhagen, Denmark..
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    Natl Inst Hlth & Welf, Helsinki, Finland..
    Topbas, Murat
    Karadeniz Tech Univ, Trabzon, Turkey..
    Topor-Madry, Roman
    Jagiellonian Univ, Coll Med, PL-31007 Krakow, Poland..
    Jose Tormo, Maria
    Murcia Reg Hlth Council, Murcia, Spain..
    Torrent, Maties
    IB SALUT Area Salut Menorca, Palma De Mallorca, Spain..
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    Inst Rech Dev, Marseille, France..
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    Harvard TH Chan Sch Publ Hlth, Boston, MA USA..
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    Hellen Hlth Fdn, Athens, Greece..
    Trinh, Oanh T. H.
    Univ Pharm & Med Ho Chi Minh City, Ho Chi Minh City, Vietnam..
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    Govt Med Coll, Bhavnagar, Gujarat, India..
    Tshepo, Lechaba
    Sefako Makgatho Hlth Sci Univ, Pretoria, South Africa..
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    Univ West Indies, Kingston, Jamaica..
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    Univ Eastern Finland, Joensuu, Finland..
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    Minist Hlth, Wellington, New Zealand..
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    Karolinska Inst, S-10401 Stockholm, Sweden..
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    Univ Bordeaux, Bordeaux, France..
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    Univ Ctr Occidental Lisandro Alvarado, Lara, Venezuela..
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    Univ Tampere, Tays Eye Ctr, FIN-33101 Tampere, Finland..
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    Pontificia Univ Catolica Chile, Santiago, Chile..
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    Harvard TH Chan Sch Publ Hlth, Boston, MA USA..
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    Univ Med Ctr Utrecht, Utrecht, Netherlands..
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    Acad Med Ctr Amsterdam, Amsterdam, Netherlands..
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    Katholieke Univ Leuven, Leuven, Belgium..
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    Ctr Prevenz Cardiovasc Udine, Udine, Italy..
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    Norwegian Univ Sci & Technol, Trondheim, Norway..
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    Consejeria Sanidad Junta de Castilla & Leon, Valladolid, Spain..
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    Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil..
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    Univ Insubria, Varese, Italy..
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    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands..
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    Inst Trop Med, Antwerp, Belgium..
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    Finnish Inst Occupat Hlth, Helsinki, Finland..
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    Imperial Coll London, London W2 1PG, England..
    Vioque, Jesus
    Univ Miguel Hernandez, Elche, Spain..
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    Univ Eastern Finland, Joensuu, Finland..
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    INSERM, F-75654 Paris 13, France..
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    Minist Hlth, Mt Fleuri, Seychelles..
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    Univ Lausanne Hosp, Lausanne, Switzerland..
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    UHC Zagreb, Zagreb, Croatia..
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    Univ Witwatersrand, ZA-2050 Johannesburg, South Africa..
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    Xinjiang Med Univ, Urumqi, Peoples R China..
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    Beijing Tongren Hosp, Beijing, Peoples R China..
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    Univ West Indies, Kingston, Jamaica..
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    Univ Manchester, Manchester M13 9PL, Lancs, England..
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    Minist Agr, Inst Food & Nutr Dev, Beijing, Peoples R China..
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    Fudan Univ, Childrens Hosp, Shanghai, Peoples R China..
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    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
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    Univ Cyprus, CY-1678 Nicosia, Cyprus..
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    Niigata Univ, Niigata, Japan..
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    Univ West Indies, Kingston, Jamaica..
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    Zambon, Sabina
    Univ Padua, I-35100 Padua, Italy..
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    Med Univ Gdansk, Gdansk, Poland..
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    Duke Univ, Durham, NC 27706 USA.;Peking Univ, Beijing, Peoples R China..
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    Capital Med Univ, Beijing An Zhen Hosp, Beijing, Peoples R China..
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    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
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    Singapore Eye Res Inst, Singapore, Singapore..
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    Inner Mongolia Med Univ, Hohhot, Peoples R China..
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    Bispebjerg Hosp, Copenhagen, Denmark.;Frederiksberg Univ Hosp, Frederiksberg, Denmark..
    Zuniga Cisneros, Julio
    Gorgas Mem Inst Hlth Studies, Panama City, Panama..
    Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants2017Inngår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 389, nr 10064, s. 37-55Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings We pooled 1479 studies that had measured the blood pressures of 19.1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127.0 mm Hg (95% credible interval 125.7-128.3) in men and 122.3 mm Hg (121.0-123.6) in women; age-standardised mean diastolic blood pressure was 78.7 mm Hg (77.9-79.5) for men and 76.7 mm Hg (75.9-77.6) for women. Global age-standardised prevalence of raised blood pressure was 24.1% (21.4-27.1) in men and 20.1% (17.8-22.5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in east and southeast Asia, south Asia, Oceania, and sub-Saharan Africa. In 2015, central and eastern Europe, sub-Saharan Africa, and south Asia had the highest blood pressure levels. Prevalence of raised blood pressure decreased in high-income and some middle-income countries; it remained unchanged elsewhere. The number of adults with raised blood pressure increased from 594 million in 1975 to 1.13 billion in 2015, with the increase largely in low-income and middle-income countries. The global increase in the number of adults with raised blood pressure is a net effect of increase due to population growth and ageing, and decrease due to declining age-specific prevalence. Interpretation During the past four decades, the highest worldwide blood pressure levels have shifted from high-income countries to low-income countries in south Asia and sub-Saharan Africa due to opposite trends, while blood pressure has been persistently high in central and eastern Europe. Funding Wellcome Trust.

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    Imperial Coll London, London W2 1PG, England.
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    Harvard TH Chan, Sch Publ Hlth, Boston, MA USA.
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    Cleveland Clin, Cleveland, OH USA.
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    Imperial Coll London, London W2 1PG, England.
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    Univ Peruana Cayetano Heredia, Lima, Peru.
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    Univ Tehran Med Sci, Tehran, Iran. Minist Hlth & Med Educ, Qods, Iran.
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    Uganda Heart Inst, Kampala, Uganda.
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    Imperial Coll London, London W2 1PG, England.
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    Imperial Coll London, London W2 1PG, England.
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    World Hlth Org, Geneva, Switzerland.
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    World Hlth Org, Geneva, Switzerland.
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    World Hlth Org, Geneva, Switzerland.
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    Univ Oxford, Oxford, England.
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    Univ West Indies, Kingston, Barbados.
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    South African Med Res Council, Pietermaritzburg, South Africa.
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    Seoul Natl Univ, Seoul, South Korea.
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    Natl Inst Nutr, Hyderabad, Telangana, India.
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    Robert Koch Inst, Berlin, Germany;Robert Koch Inst, Berlin, Germany;German Ctr Cardiovasc Res, Munich, Germany;German Ctr Cardiovascular Res, Gottingen, Germany.
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    Univ Zagreb, Zagreb, Croatia;Univ Zagreb, Zagreb, Croatia.
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    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).
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    Univ Oxford, Oxford, England;Univ Oxford, Oxford, England;Univ New South Wales, Sydney, NSW, Australia;Univ New South Wales, Kensington, NSW, Australia.
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    Caja Costarricense Seguro Social, San Jose, Costa Rica.
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    Al Quds Univ, Al bireh, Palestine.
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    Birzeit Univ, Birzeit, Israel.
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    Inst Mexicano Seguro Social, Mexico City, DF, Mexico.
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    Univ Adelaide, Adelaide, SA, Australia.
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    Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico.
    Agyemang, Charles
    Univ Amsterdam, Amsterdam, Netherlands.
    Ahmad, Noor Ani
    Minist Hlth Malaysia, Putrajaya, Malaysia.
    Ahmadvand, Alireza
    Non Communicable Dis Res Ctr, Shiraz, Iran.
    Ahrens, Wolfgang
    BIPS, Leibniz Inst Prevent Res & Epidemiol, Bremen, Germany.
    Ajlouni, Kamel
    Natl Ctr Diabet & Endocrinol, Amman, Jordan.
    Akhtaeva, Nazgul
    Kazakh Natl Med Univ, Alma Ata, Kazakhstan.
    Al-Raddadi, Rajaa
    King Abdulaziz Univ, Jeddah, Saudi Arabia.
    Ali, Mohamed M.
    World Hlth Org, Geneva, Switzerland.
    Ali, Osman
    Univ Malaysia Sabah, Kota Kinabalu, Malaysia.
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Strassen, Luxembourg.
    Aly, Eman
    World Hlth Org Reg Off Eastern Mediterranean, Nasr City, Egypt.
    Amarapurkar, Deepak N.
    Bombay Hosp & Med Res Ctr, Bombay, Maharashtra, India;Med Res Ctr, Bombay, Maharashtra, India.
    Amouyel, Philippe
    Lille Univ & Hosp, Lille, France.
    Amuzu, Antoinette
    London Sch Hyg Trop Med, London, England.
    Andersen, Lars Bo
    Western Norway Univ Appl Sci, Bergen, Norway.
    Anderssen, Sigmund A.
    Norwegian Sch Sport Sci, Oslo, Norway.
    Angquist, Lars H.
    Frederiksberg Univ Hosp, Frederiksberg, Denmark;Bispebjerg Hosp, Copenhagen, Denmark.
    Anjana, Ranjit Mohan
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India.
    Ansong, Daniel
    Komfo Anokye Teaching Hosp, Kumasi, Ghana.
    Aounallah-Skhiri, Hajer
    Natl Inst Publ Hlth, Tunis, Tunisia.
    Araujo, Joana
    Univ Porto, Porto, Portugal.
    Ariansen, Inger
    Norwegian Inst Publ Hlth, Oslo, Norway.
    Aris, Tahir
    Minist Hlth Malaysia, Putrajaya, Malaysia.
    Arlappa, Nimmathota
    Natl Inst Nutr, Hyderabad, Telangana, India.
    Arveiler, Dominique
    Strasbourg Univ & Hosp, Strasbourg, France.
    Aryal, Krishna K.
    Nepal Hlth Res Council, Kathmandu, Nepal.
    Aspelund, Thor
    Univ Iceland, Reykjavik, Iceland.
    Assah, Felix K.
    Univ Yaounde I, Yaounde, Cameroon.
    Assuncao, Maria Cecilia F.
    Univ Fed Pelotas, Pelotas, Brazil.
    Avdicova, Maria
    Reg Author Publ Hlth, Banska Bystrica, Slovakia.
    Azevedo, Ana
    Univ Porto, Med Sch, Porto, Portugal.
    Azizi, Fereidoun
    Shahid Beheshti Univ Med Sci, Tehran, Iran.
    Babu, Bontha V.
    Indian Council Med Res, New Delhi, India.
    Bahijri, Suhad
    King Abdulaziz Univ, Jeddah, Saudi Arabia.
    Balakrishna, Nagalla
    Natl Inst Nutr, Hyderabad, Telangana, India.
    Bamoshmoosh, Mohamed
    Univ Sci & Technol, Taizi, Yemen.
    Banach, Maciej
    Bandosz, Piotr
    Banegas, Jose R.
    Univ Autonoma Madrid, Madrid, Spain.
    Barbagallo, Carlo M.
    Univ Palermo, Palermo, Italy.
    Barcelo, Alberto
    Pan Amer Hlth Org, Washington, DC USA.
    Barkat, Amina
    Univ Mohammed V Rabat, Rabat, Morocco.
    Barros, Aluisio J. D.
    Univ Fed Pelotas, Pelotas, Brazil.
    Barros, Mauro V.
    Univ Pernambuco, Recife, PE, Brazil.
    Bata, Iqbal
    Dalhousie Univ, Halifax, NS, Canada.
    Batieha, Anwar M.
    Jordan Univ Sci & Technol, Irbid, Jordan.
    Batyrbek, Assembekov
    Kazakh Natl Med Univ, Alma Ata, Kazakhstan.
    Baur, Louise A.
    Univ Sydney, Sydney, NSW, Australia.
    Beaglehole, Robert
    Univ Auckland, Auckland, New Zealand.
    Ben Romdhane, Habiba
    Univ Tunis El Manar, Tunis, Tunisia.
    Benet, Mikhail
    CAFAM Univ Fdn, Bogota, Colombia.
    Benson, Lowell S.
    Univ Utah, Sch Med, Salt Lake City, UT USA.
    Bernabe-Ortiz, Antonio
    Univ Peruana Cayetano Heredia, Lima, Peru.
    Bernotiene, Gailute
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Bettiol, Heloisa
    Univ Sao Paulo, Sao Paulo, Brazil.
    Bhagyalaxmi, Aroor
    BJ Med Coll, Ahmadabad, Gujarat, India.
    Bharadwaj, Sumit
    Chirayu Med Coll, Bhopal, India.
    Bhargava, Santosh K.
    SL Jain Hosp, Delhi, India.
    Bi, Yufang
    Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China.
    Bikbov, Mukharram
    Ufa Eye Res Inst, Ufa, Russia.
    Bista, Bihungum
    Nepal Hlth Res Council, Kathmandu, Nepal.
    Bjerregaard, Peter
    Univ Greenland, Nuuk, Greenland;Univ Southern, Odense, Denmark.
    Bjertness, Espen
    Univ Oslo, Oslo, Norway.
    Bjertness, Marius B.
    Univ Oslo, Oslo, Norway.
    Bjorkelund, Cecilia
    Univ Gothenburg, Gothenburg, Sweden.
    Blokstra, Anneke
    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands.
    Bo, Simona
    Univ Turin, Turin, Italy.
    Bobak, Martin
    UCL, London, England.
    Boeing, Heiner
    German Inst Human Nutr, Berlin, Germany.
    Boggia, Jose G.
    Univ Republica, Montevideo, Uruguay.
    Boissonnet, Carlos P.
    CEMIC, Buenos Aires, DF, Argentina.
    Bongard, Vanina
    Toulouse Univ, Sch Med, Toulouse, France.
    Borchini, Rossana
    Univ Hosp Varese, Varese, Italy.
    Bovet, Pascal
    Minist Hlth, Victoria, Seychelles;Univ Lausanne, Lausanne, Switzerland.
    Braeckman, Lutgart
    Univ Ghent, Ghent, Belgium.
    Brajkovich, Imperia
    Univ Cent Venezuela, Caracas, Venezuela.
    Branca, Francesco
    World Hlth Org, Geneva, Switzerland.
    Breckenkamp, Juergen
    Bielefeld Univ, Bielefeld, Germany.
    Brenner, Hermann
    German Canc Res Ctr, Heidelberg, Germany.
    Brewster, Lizzy M.
    Univ Amsterdam, Amsterdam, Netherlands.
    Bruno, Graziella
    Univ Turin, Turin, Italy.
    Bueno-de-Mesquita, H.B.
    National Institute for Public Health and the Environment, The Netherlands.
    Bugge, Anna
    Univ Southern Denmark, Odense, Denmark.
    Burns, Con
    Cork Inst Technol, Cork, Ireland.
    Bursztyn, Michael
    Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel.
    Cabrera de Leon, Antonio
    Univ La Laguna, San Cristobal la Laguna, Spain.
    Cacciottolo, Joseph
    Univ Malta, Msida, Malta.
    Cai, Hui
    Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA.
    Cameron, Christine
    Canadian Fitness & Lifestyle Res Inst, Ottawa, ON, Canada.
    Can, Gunay
    Istanbul Univ, Istanbul, Turkey.
    Candido, Ana Paula C.
    Univ Fed Juiz De Fora, Juiz De Fora, Brazil.
    Capuano, Vincenzo
    Cardiol Mercato S Severino, Mercato San Severino, Italy.
    Cardoso, Viviane C.
    Univ Sao Paulo, Sao Paulo, Brazil.
    Carlsson, Axel C.
    Karolinska Inst, Solna, Sweden.
    Carvalho, Maria J.
    Univ Porto, Porto, Portugal.
    Casanueva, Felipe F.
    Univ Santiago Compostela, Santiago, Spain.
    Casas, Juan-Pablo
    UCL, London, England.
    Caserta, Carmelo A.
    Chamukuttan, Snehalatha
    Chan, Angelique W.
    Duke NUS Med Sch, Singapore, Singapore.
    Chan, Queenie
    Imperial Coll London, London W2 1PG, England.
    Chaturvedi, Himanshu K.
    Natl Inst Med Stat, New Delhi, India.
    Chaturvedi, Nishi
    UCL, London, England.
    Chen, Chien-Jen
    Acad Sinica, Taipei, Taiwan.
    Chen, Fangfang
    Capital Inst Pediat, Beijing, Peoples R China. Duke Univ, Durham, NC USA.
    Chen, Huashuai
    Chen, Shuohua
    Kailuan Gen Hosp, Tangshan, Peoples R China.
    Cheng, Ching-Yu
    Duke NUS Med Sch, Singapore, Singapore.
    Cherkaoui Dekkaki, Imane
    Univ Mohammed V Rabat, Rabat, Morocco.
    Chetrit, Angela
    Gertner Inst Epidemiol & Hlth Policy Res, Tel Aviv, Israel.
    Chiolero, Arnaud
    Univ Bern, Bern, Switzerland.
    Chiou, Shu-Ti
    Minist Hlth & Welf, Taipei, Taiwan.
    Chirita-Emandi, Adela
    Victor Babes Univ Med & Pharm Timisoara, Timisoara, Romania.
    Chirlaque, Maria-Dolores
    Murcia Reg Hlth Council, Murcia, Spain.
    Cho, Belong
    Seoul Natl Univ, Coll Med, Seoul, South Korea.
    Cho, Yumi
    Korea Centers Dis Control & Prevent, Cheongju, South Korea.
    Christofaro, Diego G.
    Univ Estadual Paulista, Sao Paulo, Brazil.
    Chudek, Jerzy
    Med Univ Silesia, Katowice, Poland.
    Cifkova, Renata
    Charles Univ Prague, Prague, Czech Republic.
    Cinteza, Eliza
    Carol Davila Univ Med & Pharm, Bucharest, Romania.
    Claessens, Frank
    Katholieke Univ Leuven, Leuven, Belgium.
    Clays, Els
    Univ Ghent, Ghent, Belgium.
    Concin, Hans
    Agcy Prevent & Social Med, Vienna, Austria.
    Cooper, Cyrus
    Univ Southampton, Southampton, Hants, England.
    Cooper, Rachel
    UCL, London, England.
    Coppinger, Tara C.
    Cork Inst Technol, Cork, Ireland.
    Costanzo, Simona
    IRCCS Ist Neurol Mediterraneo Neuromed, Pozzilli, Italy.
    Cottel, Dominique
    Inst Pasteur, Lille, France.
    Cowell, Chris
    Univ Sydney, Sydney, NSW, Australia.
    Craig, Cora L.
    Canadian Fitness & Lifestyle Res Inst, Ottawa, ON, Canada.
    Crujeiras, Ana B.
    CIBEROBN, Madrid, Spain.
    Cruz, Juan J.
    Univ Autonoma Madrid, Madrid, Spain.
    D'Arrigo, Graziella
    Natl Council Res, Rome, Italy.
    d'Orsi, Eleonora
    Univ Fed Santa Catarina, Florianopolis, SC, Brazil.
    Dallongeville, Jean
    Inst Pasteur, Lille, France.
    Damasceno, Albertino
    Eduardo Mondlane Univ, Maputo, Mozambique.
    Dankner, Rachel
    Gertner Inst Epidemiol & Hlth Policy Res, Tel Aviv, Israel.
    Dantoft, Thomas M.
    Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark.
    Dauchet, Luc
    Lille Univ & Hosp, Lille, France.
    Davletov, Kairat
    Kazakh Natl Med Univ, Alma Ata, Kazakhstan.
    De Backer, Guy
    Univ Ghent, Ghent, Belgium.
    De Bacquer, Dirk
    Univ Ghent, Ghent, Belgium.
    de Gaetano, Giovanni
    IRCCS Ist Neurol Mediterraneo Neuromed, Pozzilli, Italy.
    De Henauw, Stefaan
    Univ Ghent, Ghent, Belgium.
    de Oliveira, Paula Duarte
    Univ Fed Pelotas, Pelotas, Brazil.
    De Smedt, Delphine
    Univ Ghent, Ghent, Belgium.
    Deepa, Mohan
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India.
    Dehghan, Abbas
    Erasmus MC, Rotterdam, Netherlands.
    Delisle, Helene
    Univ Montreal, Montreal, PQ, Canada.
    Deschamps, Valerie
    French Publ Hlth Agcy, St Maurice, France.
    Dhana, Klodian
    Erasmus MC, Rotterdam, Netherlands.
    Di Castelnuovo, Augusto F.
    IRCCS Ist Neurol Mediterraneo Neuromed, Pozzilli, Italy.
    Dias-da-Costa, Juvenal Soares
    Univ Do Vale Do Rio Dos Sinos, Sao Leopoldo, Brazil.
    Diaz, Alejandro
    Natl Council Sci & Tech Res, Buenos Aires, DF, Argentina.
    Dickerson, Ty T.
    Univ Utah, Sch Med, Salt Lake City, UT USA.
    Do, Ha T. P.
    Natl Inst Nutr, Hyderabad, Telangana, India.
    Dobson, Annette J.
    Univ Queensland, Brisbane, Qld, Australia.
    Donfrancesco, Chiara
    Ist Super Sanita, Rome, Italy.
    Donoso, Silvana P.
    Univ Cuenca, Cuenca, Ecuador.
    Doering, Angela
    Helmholtz Zentrum Munchen, Oberschleissheim, Germany.
    Dorobantu, Maria
    Carol Davila Univ Med & Pharm, Bucharest, Romania.
    Doua, Kouamelan
    Minist Sante & Lutte Contre Sida, Abidjan, Cote Ivoire.
    Drygas, Wojciech
    Cardinal Wyszynski Inst Cardiol, Warsaw, Poland.
    Dulskiene, Virginija
    Dzakula, Aleksandar
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania;Univ Zagreb, Zagreb, Croatia.
    Dzerve, Vilnis
    Univ Latvia, Riga, Latvia.
    Dziankowska-Zaborszczyk, Elzbieta
    Eggertsen, Robert
    Univ Gothenburg, Gothenburg, Sweden.
    Ekelund, Ulf
    Norwegian Sch Sport Sci, Oslo, Norway.
    El Ati, Jalila
    Natl Inst Nutr & Food Technol, Tunis, Tunisia. Inst Hosp Del Mar dInvest Med, Barcelona, Spain.
    Elliott, Paul
    Imperial Coll London, London W2 1PG, England.
    Elosua, Roberto
    Erasmus, Rajiv T.
    Univ Stellenbosch, Stellenbosch, South Africa.
    Erem, Cihangir
    Karadeniz Tech Univ, Trabzon, Turkey.
    Eriksen, Louise
    Univ Southern Denmark, Odense, Denmark.
    Eriksson, Johan G.
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Escobedo-de la Pena, Jorge
    Inst Mexicano Seguro Social, Mexico City, DF, Mexico.
    Evans, Alun
    Queens Univ Belfast, Belfast, Antrim, North Ireland.
    Faeh, David
    Univ Zurich, Zurich, Switzerland.
    Fall, Caroline H.
    Univ Southampton, Southampton, Hants, England.
    Farzadfar, Farshad
    Univ Tehran Med Sci, Tehran, Iran. Minist Hlth & Med Educ, Qods, Iran.
    Felix-Redondo, Francisco J.
    Centro Salud Villanueva Norte, Villanueva de la Serena, Spain.
    Ferguson, Trevor S.
    Univ West Indies, Kingston, Jamaica.
    Fernandes, Romulo A.
    Univ Estadual Paulista, Sao Paulo, Brazil.
    Fernandez-Berges, Daniel
    Hosp Don Benito Villanueva Serena, Badajoz, Spain.
    Ferrante, Daniel
    Minist Hlth, Buenos Aires, DF, Argentina.
    Ferrari, Marika
    Council Agr Res & Econ, Arezzo, Italy.
    Ferreccio, Catterina
    Pontificia Univ Catolica Chile, Santiago, Chile.
    Ferrieres, Jean
    Toulouse Univ, Sch Med, Toulouse, France.
    Finn, Joseph D.
    Univ Manchester, Manchester, Lancs, England.
    Fischer, Krista
    Univ Tartu, Tartu, Estonia.
    Foger, Bernhard
    Agcy Prevent & Social Med, Vienna, Austria.
    Foo, Leng Huat
    Univ Sains Malaysia, George Town, Malaysia.
    Forslund, Ann-Sofie
    Umea Univ, Umea, Sweden.
    Forsner, Maria
    Dalarna Univ, Falun, Sweden.
    Fouad, Heba M.
    World Hlth Org Reg Off Eastern Mediterranean, Nasr City, Egypt.
    Francis, Damian K.
    Univ West Indies, Kingston, Barbados.
    Franco, Maria do Carmo
    Univ Fed Sao Paulo, Sao Paulo, Brazil.
    Franco, Oscar H.
    Erasmus MC, Rotterdam, Netherlands.
    Frontera, Guillermo
    Hosp Univ Son Espases, Palma de Mallorca, Spain.
    Fuchs, Flavio D.
    Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.
    Fuchs, Sandra C.
    Univ Fed Rio Grande, Porto Alegre, RS, Brazil.
    Fujita, Yuki
    Kindai Univ, Higashiosaka, Osaka, Japan.
    Furusawa, Takuro
    Kyoto Univ, Kyoto, Japan.
    Gaciong, Zbigniew
    Med Univ Warsaw, Warsaw, Poland.
    Galvano, Fabio
    Univ Catania, Catania, Italy.
    Garcia-de-la-Hera, Manoli
    CIBER Epidemiol & Salud Publ, Madrid, Spain.
    Gareta, Dickman
    Univ KwaZulu Natal, Durban, South Africa.
    Garnett, Sarah P.
    Univ Sydney, Sydney, NSW, Australia.
    Gaspoz, Jean-Michel
    Geneva Univ Hosp, Geneva, Switzerland.
    Gasull, Magda
    CIBER Epidemiol & Salud Publ, Madrid, Spain.
    Gates, Louise
    Australian Bur Stat, Canberra, ACT, Australia.
    Geleijnse, Johanna M.
    Wageningen Univ, Wageningen, Netherlands.
    Ghasemian, Anoosheh
    Non Communicable Dis Res Ctr, Shiraz, Iran.
    Ghimire, Anup
    B P Koirala Inst Hlth Sci, Dharan, Nepal.
    Giampaoli, Simona
    Ist Super Sanita, Rome, Italy.
    Gianfagna, Francesco
    IRCCS Ist Neurol Mediterraneo Neuromed, Pozzilli, Italy;Univ Insubria, Varese, Italy.
    Gill, Tiffany K.
    Univ Adelaide, Adelaide, SA, Australia.
    Giovannelli, Jonathan
    Lille Univ & Hosp, Lille, France.
    Goldsmith, Rebecca A.
    Minist Hlth, Buenos Aires, DF, Argentina.
    Goncalves, Helen
    Univ Fed Pelotas, Pelotas, Brazil.
    Gonzalez-Gross, Marcela
    Univ Politecn Madrid, Madrid, Spain.
    Gonzalez-Rivas, Juan P.
    Andes Clin Cardio Metab Studies, Merida, Venezuela.
    Bonet Gorbea, Mariano
    Natl Inst Hyg Epidemiol & Microbiol, Havana, Cuba.
    Gottrand, Frederic
    Univ Lille 2, Lille, France.
    Graff-Iversen, Sidsel
    Norwegian Inst Publ Hlth, Oslo, Norway.
    Grafnetter, Dusan
    Inst Clin & Expt Med, Prague, Czech Republic.
    Grajda, Aneta
    Childrens Mem Hlth Inst, Warsaw, Poland.
    Grammatikopoulou, Maria G.
    Alexander Technol Educ Inst, Thessaloniki, Greece.
    Gregor, Ronald D.
    Dalhousie Univ, Halifax, NS, Canada.
    Grodzicki, Tomasz
    Jagiellonian Univ, Med Coll, Krakow, Poland.
    Grontved, Anders
    Univ Southern Denmark, Odense, Denmark.
    Grosso, Giuseppe
    Azienda Ospedaliera Univ Policlinico Vittorio Ema, Catania, Italy.
    Gruden, Gabriella
    Univ Turin, Turin, Italy.
    Grujic, Vera
    Univ Novi Sad, Novi Sad, Serbia.
    Gu, Dongfeng
    Natl Ctr Cardiovasc Dis, Beijing, Peoples R China.
    Guan, Ong Peng
    Singapore Eye Res Inst, Singapore, Singapore.
    Gudmundsson, Elias F.
    Iceland Heart Assoc, Reykjavik, Iceland.
    Gudnason, Vilmundur
    Univ Iceland, Reykjavik, Iceland.
    Guerrero, Ramiro
    Univ Icesi, Cali, Colombia.
    Guessous, Idris
    Geneva Univ Hosp, Geneva, Switzerland.
    Guimaraes, Andre L.
    Univ Estadual Montes Claros, Montes Claros, Brazil. Kings Coll London, London, England.
    Gulliford, Martin C.
    Gunnlaugsdottir, Johanna
    Iceland Heart Assoc, Reykjavik, Iceland.
    Gunter, Marc
    Int Agcy Res Canc, Lyon, France.
    Gupta, Prakash C.
    Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, India.
    Gupta, Rajeev
    Eternal Heart Care Ctr & Res Inst, Jaipur, Rajasthan, India.
    Gureje, Oye
    Univ Ibadan, Ibadan, Nigeria.
    Gurzkowska, Beata
    Inst Clin & Expt Med, Prague, Czech Republic.
    Gutierrez, Laura
    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina.
    Gutzwiller, Felix
    Univ Zurich, Zurich, Switzerland.
    Hadaegh, Farzad
    Shahid Beheshti Univ Med Sci, Tehran, Iran.
    Halkjaer, Jytte
    Danish Canc Soc Res Ctr, Copenhagen, Denmark.
    Hardy, Rebecca
    UCL, London, England.
    Kumar, Rachakulla Hari
    Natl Inst Nutr, Hyderabad, Telangana, India.
    Hata, Jun
    Kyushu Univ, Fukuoka, Fukuoka, Japan.
    Hayes, Alison J.
    Univ Sydney, Sydney, NSW, Australia.
    He, Jiang
    Tulane Univ, New Orleans, LA USA.
    He, Yuna
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China.
    Hendriks, Marleen Elisabeth
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Henriques, Ana
    Univ Porto, Porto, Portugal.
    Hernandez Cadena, Leticia
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico.
    Herrala, Sauli
    Oulu Univ Hosp, Oulu, Finland.
    Heshmat, Ramin
    Chron Dis Res Ctr, Tehran, Iran.
    Hihtaniemi, Ilpo Tapani
    Imperial Coll London, London W2 1PG, England.
    Ho, Sai Yin
    Univ Hong Kong, Hong Hom, Hong Kong, Peoples R China.
    Ho, Suzanne C.
    Chinese Univ Hong Kong, Hong Hom, Hong Kong, Peoples R China.
    Hobbs, Michael
    Univ Western Australia, Perth, WA, Australia.
    Hofman, Albert
    Erasmus MC, Rotterdam, Netherlands.
    Dinc, Gonul Horasan
    Celal Bayar Univ, Manisa, Turkey.
    Horimoto, Andrea R. V. R.
    Heart Inst, Sao Paulo, Brazil.
    Hormiga, Claudia M.
    Fdn Oftalmol Santander, Bucaramanga, Colombia.
    Horta, Bernardo L.
    Univ Fed Pelotas, Pelotas, Brazil.
    Houti, Leila
    Howitt, Christina
    Univ West Indies, Kingston, Barbados.
    Htay, Thein Thein
    Independent Publ Hlth Specialist, Yangon, Myanmar.
    Htet, Aung Soe
    Minist Hlth, Buenos Aires, DF, Argentina.
    Htike, Maung Maung Than
    Minist Hlth, Buenos Aires, DF, Argentina.
    Hu, Yonghua
    Peking Univ, Beijing, Peoples R China.
    Maria Huerta, Jose
    CIBER Epidemiol & Salud Publ, Madrid, Spain.
    Huisman, Martijn
    Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands;Vrije Univ Amsterdam, Amsterdam, Netherlands.
    Husseini, Abdullatif S.
    Birzeit Univ, Birzeit, Palestine.
    Huybrechts, Inge
    Int Agcy Res Canc, Lyon, France.
    Hwalla, Nahla
    Amer Univ Beirut, Beirut, Lebanon.
    Iacoviello, Licia
    IRCCS Ist Neurol Mediterraneo Neuromed, Pozzilli, Italy;Univ Insubria, Varese, Italy.
    Iannone, Anna G.
    Cardiol Mercato S Severino, Mercato San Severino, Italy.
    Ibrahim, Mohsen M.
    Cairo Univ, Cairo, Egypt.
    Wong, Norazizah Ibrahim
    Minist Hlth Malaysia, Putrajaya, Malaysia.
    Ikeda, Nayu
    Ikram, M. Arfan
    Erasmus MC, Rotterdam, Netherlands.
    Irazola, Vilma E.
    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina.
    Islam, Muhammad
    Aga Khan Univ, Karachi, Pakistan.
    Ismail, Aziz al-Safi
    Univ Sains Malaysia, George Town, Malaysia.
    Ivkovic, Vanja
    UHC Zagreb, Zagreb, Croatia.
    Iwasaki, Masanori
    Niigata Univ, Niigata, Japan.
    Jacobs, Jeremy M.
    Hadassah Univ Med Ctr, Jerusalem, Israel.
    Jaddou, Hashem
    Jordan Univ Sci & Technol, Irbid, Jordan.
    Jafar, Tazeen
    Duke NUS Med Sch, Singapore, Singapore.
    Jamrozik, Konrad
    Univ Adelaide, Adelaide, SA, Australia.
    Janszky, Imre
    Norwegian Univ Sci & Technol, Trondheim, Norway.
    Jasienska, Grazyna
    Jagiellonian Univ, Med Coll, Krakow, Poland.
    Jelakovic, Ana
    UHC Zagreb, Zagreb, Croatia.
    Jelakovic, Bojan
    Univ Zagreb, Coll Med, Zagreb, Croatia.
    Jennings, Garry
    Heart Fdn, Melbourne, Vic, Australia.
    Jeong, Seung-lyeal
    Natl Hlth Insurance Serv, Jeonju, South Korea.
    Jiang, Chao Qiang
    Guangzhou 12th Hosp, Guangzhou, Peoples R China.
    Joffres, Michel
    Simon Fraser Univ, Burnaby, BC, Canada.
    Johansson, Mattias
    Int Agcy Res Canc, Lyon, France.
    Jokelainen, Jari J.
    Oulu Univ Hosp, Oulu, Finland.
    Jonas, Jost B.
    Heidelberg Univ, Heidelberg, Germany.
    Jorgensen, Torben
    Res Ctr Prevent & Hlth, Glostrup, Denmark.
    Joshi, Pradeep
    World Hlth Org Country Off, Delhi, India.
    Jozwiak, Jacek
    Czestochowa Tech Univ, Czestochowa, Poland.
    Juolevi, Anne
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Jurak, Gregor
    Univ Ljubljana, Ljubljana, Slovenia.
    Juresa, Vesna
    Univ Zagreb, Zagreb, Croatia.
    Kaaks, Rudolf
    German Canc Res Ctr, Heidelberg, Germany.
    Kafatos, Anthony
    Univ Crete, Iraklion, Greece.
    Kajantie, Eero O.
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Kalter-Leibovici, Ofra
    Gertner Inst Epidemiol & Hlth Policy Res, Tel Aviv, Israel.
    Kamaruddin, Nor Azmi
    Univ Kebangsaan Malaysia, Bangi, Malaysia.
    Karki, Khem B.
    Kasaeian, Amir
    Univ Tehran Med Sci, Tehran, Iran. Minist Hlth & Med Educ, Qods, Iran.
    Katz, Joanne
    Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
    Kauhanen, Jussi
    Univ Eastern Finland, Kuopio, Finland.
    Kaur, Prabhdeep
    Natl Inst Epidemiol, Madras, Tamil Nadu, India.
    Kavousi, Maryam
    Erasmus MC, Rotterdam, Netherlands.
    Kazakbaeva, Gyulli
    Ufa Eye Res Inst, Ufa, Russia.
    Keil, Ulrich
    Univ Munster, Munster, Germany.
    Boker, Lital Keinan
    Israel Ctr Dis Control, Tel Hashomer, Israel.
    Keinanen-Kiukaanniemi, Sirkka
    Oulu Univ Hosp, Oulu, Finland.
    Kelishadi, Roya
    Res Inst Primordial Prevent Non communicable Dis, Esfahan, Iran.
    Kemper, Han C. G.
    Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands.
    Kengne, Andre P.
    South African Med Res Council, Durban, South Africa.
    Kerimkulova, Alina
    Kyrgyz State Med Acad, Bishkek, Kyrgyzstan.
    Kersting, Mathilde
    Res Inst Child Nutr, Bonn, Germany.
    Key, Timothy
    Univ Oxford, Oxford, England.
    Khader, Yousef Saleh
    Jordan Univ Sci & Technol, Irbid, Jordan.
    Khalili, Davood
    Shahid Beheshti Univ Med Sci, Tehran, Iran.
    Khateeb, Mohammad
    Natl Ctr Diabet & Endocrinol, Amman, Jordan.
    Khaw, Kay-Tee
    Univ Cambridge, Cambridge, England.
    Kiechl-Kohlendorfer, Ursula
    Med Univ Innsbruck, Innsbruck, Austria.
    Kiechl, Stefan
    Med Univ Innsbruck, Innsbruck, Austria.
    Killewo, Japhet
    Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania.
    Kim, Jeongseon
    Natl Canc Ctr, Goyang, South Korea.
    Kim, Yeon-Yong
    Natl Hlth Insurance Serv, Jeonju, South Korea.
    Klumbiene, Jurate
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Knoflach, Michael
    Med Univ Innsbruck, Innsbruck, Austria.
    Kolle, Elin
    Norwegian Sch Sport Sci, Oslo, Norway.
    Kolsteren, Patrick
    Inst Trop Med, Antwerp, Belgium.
    Korrovits, Paul
    Tartu Univ Clin, Tartu, Estonia.
    Koskinen, Seppo
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Kouda, Katsuyasu
    Kindai Univ, Higashiosaka, Osaka, Japan.
    Kowlessur, Sudhir
    Minist Hlth & Qual Life, Port Louis, Mauritius.
    Koziel, Slawomir
    Polish Acad Sci, Anthropol Unit, Wroclaw, Poland.
    Kriemler, Susi
    Univ Zurich, Zurich, Switzerland.
    Kristensen, Peter Lund
    Univ Southern Denmark, Odense, Denmark.
    Krokstad, Steinar
    Norwegian Univ Sci & Technol, Trondheim, Norway.
    Kromhout, Daan
    Univ Groningen, Groningen, Netherlands.
    Kruger, Herculina S.
    North West Univ, Potchefstroom, South Africa.
    Kubinova, Ruzena
    Natl Inst Publ Hlth, Prague, Czech Republic.
    Kuciene, Renata
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Kuh, Diana
    UCL, London, England.
    Kujala, Urho M.
    Univ Jyvaskyla, Jyvaskyla, Finland.
    Kulaga, Zbigniew
    Childrens Mem Hlth Inst, Warsaw, Poland.
    Kumar, R. Krishna
    Amrita Inst Med Sci, Kochi, Kerala, India. Cardinal Wyszynski Inst Cardiol, Warsaw, Poland.
    Kurjata, Pawel
    Kusuma, Yadlapalli S.
    All India Inst Med Sci, New Delhi, India.
    Kuulasmaa, Kari
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Kyobutungi, Catherine
    African Populat & Hlth Res Ctr, Nairobi, Kenya.
    Laatikainen, Tiina
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Lachat, Carl
    Univ Ghent, Ghent, Belgium.
    Lam, Tai Hing
    Univ Hong Kong, Hong Hom, Hong Kong, Peoples R China.
    Landrove, Orlando
    Minist Salud Publ, Havana, Cuba.
    Lanska, Vera
    Inst Clin & Expt Med, Prague, Czech Republic.
    Lappas, Georg
    Sahlgrens Acad, Gothenburg, Sweden.
    Larijani, Bagher
    Endocrinol & Metab Res Ctr, Tehran, Iran.
    Laugsand, Lars E.
    Norwegian Univ Sci & Technol, Trondheim, Norway.
    Bao, Khanh Le Nguyen
    Le, Tuyen D.
    Natl Inst Nutr, Hyderabad, Telangana, India.
    Leclercq, Catherine
    Food & Agr Org United Nat, Rome, Italy.
    Lee, Jeannette
    Natl Univ Singapore, Singapore, Singapore.
    Lee, Jeonghee
    Natl Canc Ctr, Goyang, South Korea.
    Lehtimaki, Terho
    Tampere Univ Hosp, Tampere, Finland.
    Leon-Munoz, Luz M.
    Univ Autonoma Madrid, Madrid, Spain.
    Levitt, Naomi S.
    Univ Cape Town, Rondebosch, South Africa.
    Li, Yanping
    Harvard TH Chan, Sch Publ Hlth, Boston, MA USA.
    Lilly, Christa L.
    West Virginia Univ, Morgantown, WV USA.
    Lim, Wei-Yen
    Natl Univ Singapore, Singapore, Singapore.
    Fernanda Lima-Costa, M.
    Oswaldo Cruz Fdn Rene Rachou Res Inst, Rio De Janeiro, Brazil.
    Lin, Hsien-Ho
    Natl Taiwan Univ, Taipei, Taiwan.
    Lin, Xu
    Univ Chinese Acad Sci, Beijing, Peoples R China.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Linneberg, Allan
    Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark.
    Lissner, Lauren
    Univ Gothenburg, Gothenburg, Sweden.
    Litwin, Mieczyslaw
    Childrens Mem Hlth Inst, Warsaw, Poland.
    Lorbeer, Roberto
    Univ Med Greifswald, Greifswald, Germany.
    Lotufo, Paulo A.
    Univ Sao Paulo, Sao Paulo, Brazil.
    Eugenio Lozano, Jose
    Consejeria Sanidad Junta de Castilla & Leon, Valladolid, Spain.
    Luksiene, Dalia
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Lundqvist, Annamari
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Lunet, Nuno
    Univ Porto, Porto, Portugal.
    Lytsy, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Socialmedicinsk epidemiologi.
    Ma, Jun
    Peking Univ, Beijing, Peoples R China.
    Machado-Coelho, George L. L.
    Univ Fed Ouro Preto, Ouro Preto, MG, Brazil.
    Machi, Suka
    Jikei Univ, Sch Med, Tokyo, Japan.
    Maggi, Stefania
    CNR, Rome, Italy.
    Magliano, Dianna J.
    Baker Heart & Diabet Inst, Melbourne, Vic, Australia.
    Magriplis, Emmanuella
    Agr Univ Athens, Athens, Greece.
    Majer, Marjeta
    Univ Zagreb, Zagreb, Croatia.
    Makdisse, Marcia
    Hosp Israelita Albert Einstein, Sao Paulo, Brazil.
    Malhotra, Rahul
    Duke NUS Med Sch, Singapore, Singapore.
    Rao, Kodavanti Mallikharjuna
    Natl Inst Nutr, Hyderabad, India.
    Malyutina, Sofia
    Inst Internal & Prevent Med, Moscow, Russia.
    Manios, Yannis
    Harokopio Univ, Kallithea, Greece.
    Mann, Jim I.
    Univ Otago, Dunedin, New Zealand.
    Manzato, Enzo
    Univ Padua, I-35100 Padua, Italy.
    Margozzini, Paula
    Pontificia Univ Catolica Chile, Santiago, Chile.
    Marques-Vidal, Pedro
    Lausanne Univ Hosp, Lausanne, Switzerland.
    Marques, Larissa Pruner
    Univ Fed Santa Catarina, Florianopolis, SC, Brazil.
    Marrugat, Jaume
    CIBERCV, Madrid, Spain.
    Martorell, Reynaldo
    Emory Univ, Atlanta, GA USA.
    Mathiesen, Ellisiv B.
    UiT Arctic Univ Norway, Tromso, Norway.
    Matijasevich, Alicia
    Univ Sao Paulo, Sao Paulo, Brazil.
    Matsha, Tandi E.
    Cape Peninsula Univ Technol, Cape Town, South Africa.
    Mbanya, Jean Claude N.
    Univ Yaounde I, Yaounde, Cameroon.
    Posso, Anselmo J. Mc Donald
    Gorgas Mem Inst Hlth Studies, Panama City, Panama.
    McFarlane, Shelly R.
    Univ West Indies, Kingston, Jamaica.
    McGarvey, Stephen T.
    Brown Univ, Providence, RI USA.
    McLachlan, Stela
    Univ Edinburgh, Edinburgh, Midlothian, Scotland.
    McLean, Rachael M.
    Univ Otago, Dunedin, New Zealand.
    McLean, Scott B.
    Stat Canada, Ottawa, ON, Canada.
    McNulty, Breige A.
    Univ Coll Dublin, Dublin, Ireland.
    Mediene-Benchekor, Sounnia
    Univ Oran 1, Oran, Algeria.
    Medzioniene, Jurate
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Meirhaeghe, Aline
    INSERM, Paris, France.
    Meisinger, Christa
    Helmholtz Zentrum Munchen, Munich, Germany.
    Menezes, Ana Maria B.
    Univ Fed Pelotas, Pelotas, Brazil.
    Menon, Geetha R.
    Indian Council Med Res, New Delhi, India.
    Meshram, Indrapal I.
    Natl Inst Nutr, Hyderabad, India.
    Metspalu, Andres
    Univ Tartu, Tartu, Estonia.
    Meyer, Haakon E.
    Univ Oslo, Oslo, Norway.
    Mi, Jie
    Capital Inst Pediat, Beijing, Peoples R China.
    Mikkel, Kairit
    Univ Tartu, Tartu, Estonia.
    Miller, Jody C.
    Univ Otago, Dunedin, New Zealand.
    Minderico, Claudia S.
    Lusofona Univ, Lisbon, Portugal.
    Francisco, Juan
    Pontificia Univ Catolica Chile, Santiago, Chile.
    Jaime Miranda, J.
    Univ Peruana Cayetano Heredia, Lima, Peru.
    Mirrakhimov, Erkin
    Kyrgyz State Med Acad, Bishkek, Kyrgyzstan.
    Misigoj-Durakovic, Marjeta
    Univ Zagreb, Zagreb, Croatia.
    Modesti, Pietro A.
    Univ Firenze, Florence, Italy.
    Mohamed, Mostafa K.
    Ain Shams Univ, Cairo, Egypt.
    Mohammad, Kazem
    Univ Tehran Med Sci, Tehran, Iran.
    Mohammadifard, Noushin
    Hypertens Res Ctr, Tehran, Iran.
    Mohan, Viswanathan
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India.
    Mohanna, Salim
    Univ Peruana Cayetano Heredia, Lima, Peru.
    Yusoff, Muhammad Fadhli Mohd
    Minist Hlth Malaysia, Putrajaya, Malaysia.
    Mollehave, Line T.
    Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark.
    Moller, Niels C.
    Univ Southern Denmark, Odense, Denmark.
    Molnar, Denes
    Univ Pecs, Pecs, Hungary.
    Momenan, Amirabbas
    Shahid Beheshti Univ Med Sci, Tehran, Iran.
    Mondo, Charles K.
    Mulago Hosp, Kampala, Uganda.
    Monyeki, Kotsedi Daniel K.
    Univ Limpopo, Polokwane, South Africa.
    Moon, Jin Soo
    Seoul Natl Univ, Childrens Hosp, Seoul, South Korea.
    Moreira, Leila B.
    Univ Oran 1, Oran, Algeria;Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil.
    Morejon, Alain
    Univ Med Sci, Havana, Cuba.
    Moreno, Luis A.
    Univ Zaragoza, Zaragoza, Spain.
    Morgan, Karen
    RCSI Dublin, Dublin, Ireland.
    Moschonis, George
    La Trobe Univ, Bundoora, Vic, Australia.
    Mossakowska, Malgorzata
    Int Inst Mol & Cell Biol, Warsaw, Poland.
    Mostafa, Aya
    Ain Shams Univ, Cairo, Egypt.
    Mota, Jorge
    Univ Porto, Porto, Portugal.
    Motlagh, Mohammad Esmaeel
    Ahvaz Jundishapur Univ Med Sci, Ahwaz, Khuzestan, Iran.
    Motta, Jorge
    Gorgas Mem Inst Publ Hlth, Panama City, Panama.
    Msyamboza, Kelias P.
    WHO, Country Off, Lilongwe, Malawi.
    Mu, Thet Thet
    Dept Publ Hlth, Pyinmana, Myanmar.
    Muiesan, Maria L.
    Univ Brescia, Brescia, Italy.
    Mueller-Nurasyid, Martina
    Helmholtz Zentrum Munchen, Munich, Germany.
    Murphy, Neil
    Int Agcy Res Canc, Lyon, France.
    Mursu, Jaakko
    Univ Eastern Finland, Kuopio, Finland.
    Musil, Vera
    Univ Zagreb, Zagreb, Croatia.
    Nabipour, Iraj
    Bushehr Univ Med Sci, Bushehr, Iran.
    Nagel, Gabriele
    Ulm Univ, Ulm, Germany.
    Naidu, Balkish M.
    Minist Hlth Malaysia, Putrajaya, Malaysia.
    Nakamura, Harunobu
    Kobe Univ, Kobe, Hyogo, Japan.
    Namesna, Jana
    Reg Author Publ Hlth, Banska Bystrica, Slovakia.
    Nang, Ei Ei K.
    Natl Univ Singapore, Singapore, Singapore.
    Nangia, Vinay B.
    Suraj Eye Inst, Nagpur, Maharashtra, India.
    Narake, Sameer
    Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, India.
    Nauck, Matthias
    Univ Med Greifswald, Greifswald, Germany.
    Maria Navarrete-Munoz, Eva
    CIBER Epidemiol & Salud Publ, Madrid, Spain.
    Ndiaye, Ndeye Coumba
    INSERM, Paris, France.
    Neal, William A.
    West Virginia Univ, Morgantown, WV USA.
    Nenko, Ilona
    Jagiellonian Univ, Med Coll, Krakow, Poland.
    Neovius, Martin
    Karolinska Inst, Stockholm, Sweden.
    Nervi, Flavio
    Pontificia Univ Catolica Chile, Santiago, Chile.
    Nguyen, Chung T.
    Natl Inst Hyg & Epidemiol, Hanoi, Vietnam.
    Nguyen, D. Nguyen
    Univ Pharm & Med Ho Chi Minh City, Ho Chi Minh City, Vietnam.
    Nguyen, Quang Ngoc
    Nguyen, Quang V.
    Natl Hosp Endocrinol, Hanoi, Vietnam.
    Nieto-Martinez, Ramfis E.
    Miami Vet Affairs Healthcare Syst, Miami, FL USA.
    Niiranen, Teemu J.
    Natl Inst Hlth & Welf, Helsinki, Finland;Univ Turku Tyks, Turku, Finland.
    Ning, Guang
    Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China.
    Ninomiya, Toshiharu
    Kyushu Univ, Fukuoka, Japan.
    Nishtar, Sania
    Heartfile, Islamabad, Pakistan.
    Noale, Marianna
    CNR, Rome, Italy.
    Noboa, Oscar A.
    Univ Republica, Montevideo, Uruguay.
    Noorbala, Ahmad Ali
    Univ Tehran Med Sci, Tehran, Iran.
    Norat, Teresa
    Imperial Coll London, London, England.
    Noto, Davide
    Univ Palermo, Palermo, Italy.
    Al Nsour, Mohannad
    Eastern Mediterranean Publ Hlth Network, Amman, Jordan.
    O'Reilly, Dermot
    Queens Univ Belfast, Belfast, Antrim, North Ireland.
    Oda, Eiji
    Tachikawa Gen Hosp, Tachikawa, Tokyo, Japan.
    Oehlers, Glenn
    Acad Hosp Paramaribo, Paramaribo, Surinam.
    Oh, Kyungwon
    Korea Ctr Dis Control & Prevent, Cheongju, South Korea.
    Ohara, Kumiko
    Kobe Univ, Kobe, Hyogo, Japan.
    Olinto, Maria Teresa A.
    Univ Vale Rio dos Sinos, Sao Leopoldo, RS, Brazil.
    Oliveira, Isabel O.
    Univ Fed Pelotas, Pelotas, Brazil.
    Azahadi, Mohd
    Minist Hlth Malaysia, Putrajaya, Malaysia.
    Onat, Altan
    Istanbul Univ, Istanbul, Turkey.
    Ong, Sok King
    Minist Hlth, Bandar Seri Begawan, Brunei.
    Ono, Lariane M.
    Univ Fed Santa Catarina, Florianopolis, SC, Brazil.
    Ordunez, Pedro
    Pan Amer Hlth Org, Washington, DC USA.
    Ornelas, Rui
    Univ Madeira, Funchal,, Portugal.
    Osmond, Clive
    MRC Lifecourse Epidemiol Unit, Southampton, Hants, England.
    Ostojic, Sergej M.
    Univ Novi Sad, Novi Sad, Serbia.
    Ostovar, Afshin
    Bushehr Univ Med Sci, Bushehr, Iran.
    Otero, Johanna A.
    Fdn Oftalmol Santander, Bucaramanga, Colombia.
    Overvad, Kim
    Aarhus Univ, Aarhus, Denmark.
    Owusu-Dabo, Ellis
    Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana.
    Paccaud, Fred Michel
    Nstitute Social & Prevent Med, Bern, Switzerland.
    Padez, Cristina
    Univ Coimbra, Coimbra, Portugal.
    Pahomova, Elena
    Univ Latvia, Riga, Latvia.
    Pajak, Andrzej
    Jagiellonian Univ, Med Coll, Krakow, Poland.
    Palli, Domenico
    Canc Prevent & Res Inst, Naples, Italy.
    Palmieri, Luigi
    Ist Super Sanita, Rome, Italy.
    Pan, Wen-Harn
    Acad Sinica, Taipei, Taiwan.
    Panda-Jonas, Songhomitra
    Heidelberg Univ, Heidelberg, Germany.
    Panza, Francesco
    IRCCS Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy.
    Papandreou, Dimitrios
    Zayed Univ, Abu Dhabi, U Arab Emirates.
    Park, Soon-Woo
    Catholic Univ Daegu, Daegu, South Korea.
    Parnell, Winsome R.
    Univ Otago, Dunedin, New Zealand.
    Parsaeian, Mahboubeh
    Univ Tehran Med Sci, Tehran, Iran.
    Patel, Nikhil D.
    Jivandeep Hosp, Ahmadabad, Gujarat, India.
    Pecin, Ivan
    Univ Zagreb, Sch Med, Zagreb, Croatia;Univ Hosp Ctr Zagreb, Zagreb, Croatia.
    Pednekar, Mangesh S.
    Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, India.
    Peer, Nasheeta
    South African Med Res Council, Cape Town, South Africa.
    Peeters, Petra H.
    Univ Med Ctr Utrecht, Utrecht, Netherlands.
    Peixoto, Sergio Viana
    Fundacao Oswaldo Cruz, Rene Rachou Res Inst, Rio De Janeiro, Brazil.
    Peltonen, Markku
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Pereira, Alexandre C.
    Heart Inst, Sao Paulo, Brazil.
    Peters, Annette
    Helmholtz Zentrum Munchen, Munich, Germany.
    Petersmann, Astrid
    Univ Med Greifswald, Greifswald, Germany.
    Petkeviciene, Janina
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Pham, Son Thai
    Pigeot, Iris
    Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
    Pikhart, Hynek
    UCL, London, England.
    Pilav, Aida
    Univ Sarajevo, Sarajevo, Bosnia & Herceg.
    Pilotto, Lorenza
    Cardiovasc Prevent Ctr, Udine, Italy.
    Pitakaka, Freda
    Minist Hlth & Med Serv, Honiara, Solomon Islands.
    Piwonska, Aleksandra
    Cardinal Wyszynski Inst Cardiol, Warsaw, Poland.
    Plans-Rubio, Pedro
    Publ Hlth Agcy Catalonia, Catalonia, Spain.
    Polasek, Ozren
    Univ Split, Split, Croatia.
    Porta, Miquel
    Pontificia Univ Catolica Chile, Santiago, Chile;Inst Hosp Mar Invest Med, Barcelona, Spain.
    Portegies, Marileen L. P.
    Erasmus MC, Rotterdam, Netherlands.
    Pourshams, Akram
    Digest Oncol Res Ctr, Tehran, Iran.
    Poustchi, Hossein
    Digest Dis Res Inst, Tehran, Iran.
    Pradeepa, Rajendra
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India.
    Prashant, Mathur
    Indian Council Med Res, New Delhi, India.
    Price, Jacqueline F.
    Univ Edinburgh, Edinburgh, Midlothian, Scotland.
    Puder, Jardena J.
    Lausanne Univ Hosp, Lausanne, Switzerland.
    Puiu, Maria
    Victor Babes Univ Med & Pharm Timisoara, Timisoara, Romania.
    Punab, Margus
    Tartu Univ Clin, Tartu, Estonia.
    Qasrawi, Radwan F.
    Al Quds Univ, Jerusalem, Palestine.
    Qorbani, Mostafa
    Alborz Univ Med Sci, Alborz, Iran.
    Bao, Tran Quoc
    Radic, Ivana
    Univ Novi Sad, Novi Sad, Serbia.
    Radisauskas, Ricardas
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Rahman, Mahfuzar
    BRAC, Dhaka, Bangladesh.
    Raitakari, Olli
    Univ Turku, Turku, Finland.
    Raj, Manu
    Amrita Inst Med Sci, Coimbatore, Tamil Nadu, India.
    Rao, Sudha Ramachandra
    Natl Inst Epidemiol, Madras, Tamil Nadu, India.
    Ramachandran, Ambady
    India Diabet Res Fdn, New Delhi, India.
    Ramos, Elisabete
    Univ Porto, Med Sch, Porto, Portugal.
    Rampal, Lekhraj
    Univ Putra Malaysia, Serdang, Malaysia.
    Rampal, Sanjay
    Univ Malaya, Kuala Lumpur, Malaysia.
    Reina, Daniel A. Rangel
    Gorgas Mem Inst Hlth Studies, Panama City, Panama.
    Redon, Josep
    Univ Valencia, Valencia, Spain.
    Reganit, Paul Ferdinand M.
    Univ Philippines, Quezon City, Philippines.
    Ribeiro, Robespierre
    Minas Gerais State Secretariat Hlth, Belo Horizonte, MG, Brazil.
    Riboli, Elio
    Imperial Coll London, London, England.
    Rigo, Fernando
    Hlth Ctr San Agustin, San Agustin, Spain.
    de Wit, Tobias F. Rinke
    PharmAccess Fdn, Amsterdam, Netherlands.
    Ritti-Dias, Raphael M.
    Univ Nove de Julho, Sao Paulo, Brazil.
    Robinson, Sian M.
    Univ Southampton, Southampton SO9 5NH, Hants, England.
    Robitaille, Cynthia
    Publ Hlth Agcy Canada, Ottawa, ON, Canada.
    Rodriguez-Artalejo, Fernando
    Univ Autonoma Madrid, Madrid, Spain.
    del Cristo Rodriguez-Perez, Maria
    Canarian Hlth Serv, Tenerife, Spain.
    Rodriguez-Villamizar, Laura A.
    Univ Ind Santander, Bucaramanga, Colombia.
    Rojas-Martinez, Rosalba
    Inst Nacl Salud Publ, Cuernavaca, Morelos, Mexico.
    Romaguera, Dora
    CIBEROBN, Madrid, Spain.
    Ronkainen, Kimmo
    Univ Eastern Finland, Kuopio, Finland.
    Rosengren, Annika
    Univ Gothenburg, Gothenburg, Sweden.
    Roy, Joel G. R.
    Stat Canada, Ottawa, ON, Canada.
    Rubinstein, Adolfo
    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina.
    Sandra Ruiz-Betancourt, Blanca
    Inst Mexicano Seguro Social, Mexico City, DF, Mexico.
    Rutkowski, Marcin
    Med Univ Gdansk, Gdansk, Poland.
    Sabanayagam, Charumathi
    Singapore Eye Res Inst, Singapore, Singapore.
    Sachdev, Harshpal S.
    Sitaram Bhartia Inst Sci & Res, New Delhi, India.
    Saidi, Olfa
    Univ Tunis El Manar, Tunis, Tunisia.
    Sakarya, Sibel
    Marmara Univ, Istanbul, Turkey.
    Salanave, Benoit
    French Publ Hlth Agcy, St Maurice, France.
    Salazar Martinez, Eduardo
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico.
    Salmeron, Diego
    CIBER Epidemiol & Salud Publ, Barcelona, Spain.
    Salomaa, Veikko
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Salonen, Jukka T.
    Univ Helsinki, Helsinki, Finland.
    Salvetti, Massimo
    Univ Brescia, Brescia, Italy.
    Sanchez-Abanto, Jose
    Natl Inst Hlth, Lima, Peru.
    Sans, Susana
    Catalan Dept Hlth, Catalonia, Spain.
    Santos, Diana A.
    Univ Lisbon, Lisbon, Portugal.
    Santos, Ina S.
    Univ Fed Pelotas, Pelotas, RS, Brazil.
    dos Santos, Renata Nunes
    Univ Sao Paulo, Clin Hosp, Sao Paulo, Brazil.
    Santos, Rute
    Univ Porto, Porto, Portugal.
    Saramies, Jouko L.
    South Karelia Social & Hlth Care Dist, Lappeenranta, Finland.
    Sardinha, Luis B.
    Univ Lisbon, Lisbon, Portugal.
    Sarganas, Giselle
    Robert Koch Inst, Berlin, Germany.
    Sarrafzadegan, Nizal
    Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
    Saum, Kai-Uwe
    German Canc Res Ctr, Heidelberg, Germany.
    Savva, Savvas
    Res & Educ Inst Child Hlth, Nicosia, Cyprus.
    Scazufca, Marcia
    Univ Sao Paulo, Clin Hosp, Sao Paulo, Brazil.
    Schargrodsky, Herman
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    German Canc Res Ctr, Heidelberg, Germany.
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    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
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    Norwegian Univ Sci & Technol, Trondheim, Norway.
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    Singapore Eye Res Inst, Singapore, Singapore.
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    Amer Univ Beirut, Beirut, Lebanon.
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    Univ Fed Santa Catarina, Florianopolis, SC, Brazil.
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    India Diabet Res Fdn, Madras, Tamil Nadu, India.
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    St Vincents Hosp, Sydney, NSW, Australia.
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    Univ New South Wales, Sydney, NSW, Australia.
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    Karolinska Inst, Stockholm, Sweden.
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    Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark.
    Slowikowska-Hilczer, Jolanta
    Med Univ Lodz, Lodz, Poland.
    Slusarczyk, Przemyslaw
    Int Inst Mol & Cell Biol, Warsaw, Poland.
    Smeeth, Liam
    London Sch Hyg & Trop Med, London, England.
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    Univ Oxford, Oxford, England.
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    Acad Med Ctr, Amsterdam, Netherlands.
    So, Hung-Kwan
    Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China.
    Sobngwi, Eugene
    Univ Yaounde I, Yaounde, Cameroon.
    Soderberg, Stefan
    Umea Univ, Umea, Sweden.
    Solfrizzi, Vincenzo
    Univ Bari, Bari, Italy.
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    Lund Univ, Lund, Sweden.
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    Peking Univ, Beijing, Peoples R China.
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    Univ Copenhagen, Copenhagen, Denmark.
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    Inst Reg Sante Publ, Ouidah, Benin.
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    Univ Bordeaux, Talence, France.
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    Univ Leuven, Leuven, Belgium.
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    INSERM, Paris, France.
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    Heart Fdn, Melbourne, Vic, Australia.
    Steene-Johannessen, Jostein
    Norwegian Sch Sport Sci, Oslo, Norway.
    Stehle, Peter
    Univ Bonn, Bonn, Germany.
    Stein, Aryeh D.
    Emory Univ, Atlanta, GA USA.
    Stergiou, George S.
    Sotiria Hosp, Athens, Greece.
    Stessman, Jochanan
    Hadassah Univ, Med Ctr, Jerusalem, Israel.
    Stieber, Jutta
    Helmholtz Zentrum Munchen, Munich, Germany.
    Stoeckl, Doris
    Helmholtz Zentrum Munchen, Munich, Germany.
    Stocks, Tanja
    Lund Univ, Lund, Sweden.
    Stokwiszewski, Jakub
    Natl Inst Hyg, Natl Inst Publ Hlth, Warsaw, Poland.
    Stronks, Karien
    Univ Amsterdam, Amsterdam, Netherlands.
    Strufaldi, Maria Wany
    Univ Fed Sao Paulo, Sao Paulo, Brazil.
    Sun, Chien-An
    Fu Jen Catholic Univ, Taipei, Taiwan.
    Sung, Yn-Tz
    Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China.
    Suriyawongpaisal, Paibul
    Mahidol Univ, Bangkok, Thailand.
    Sy, Rody G.
    Univ Philippines, Quezon City, Philippines.
    Tai, E. Shyong
    Natl Univ Singapore, Singapore, Singapore.
    Tammesoo, Mari-Liis
    Univ Tartu, Tartu, Estonia.
    Tamosiunas, Abdonas
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Tan, Eng Joo
    Univ Sydney, Sydney, NSW, Australia.
    Tang, Xun
    Peking Univ, Beijing, Peoples R China.
    Tanser, Frank
    Univ KwaZulu Natal, Durban, South Africa.
    Tao, Yong
    Peking Univ, Beijing, Peoples R China.
    Tarawneh, Mohammed Rasoul
    Minist Hlth, Amman, Jordan.
    Tarqui-Mamani, Carolina B.
    Natl Inst Hlth, Lima, Peru.
    Tautu, Oana-Florentina
    Carol Davila Univ Med & Pharm, Bucharest, Romania.
    Taylor, Anne
    Univ Adelaide, Adelaide, SA, Australia.
    Theobald, Holger
    Karolinska Inst, Stockholm, Sweden.
    Theodoridis, Xenophon
    Alexander Technol Educ Inst, Sindos, Greece.
    Thijs, Lutgarde
    Univ Leuven, Leuven, Belgium.
    Thuesen, Betina H.
    Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark.
    Tjonneland, Anne
    Danish Canc Soc Res Ctr, Copenhagen, Denmark.
    Tolonen, Hanna K.
    Natl Inst Hlth & Welf, Kuopio, Finland.
    Tolstrup, Janne S.
    Univ Southern Denmark, Odense, Denmark.
    Topbas, Murat
    Karadeniz Tech Univ, Trabzon, Turkey.
    Topor-Madry, Roman
    Jagiellonian Univ, Coll Med, Warsaw, Poland.
    Jose Tormo, Maria
    Hlth Serv Murcia, Murcia, Spain.
    Torrent, Maties
    IB SALUT Area Salut Menorca, Ciutadella De Menorca, Spain.
    Traissac, Pierre
    Inst Rech Dev, Marseille, France.
    Trichopoulos, Dimitrios
    Harvard TH Chan Sch Publ Hlth, Boston, MA USA.
    Trichopoulou, Antonia
    Hellen Hlth Fdn, Athens, Greece.
    Trinh, Oanh T. H.
    Univ Pharm & Med Ho Chi Minh City, Ho Chi Minh City, Vietnam.
    Trivedi, Atul
    Govt Med Coll, New Delhi, India.
    Tshepo, Lechaba
    Sefako Makgatho Hlth Sci Univ, Tshwane, South Africa.
    Tulloch-Reid, Marshall K.
    Univ West Indies, Kingston, Jamaica.
    Tullu, Fikru
    Addis Ababa Univ, Addis Ababa, Ethiopia.
    Tuomainen, Tomi-Pekka
    Univ Eastern Finland, Kuopio, Finland.
    Tuomilehto, Jaakko
    Dasman Diabet Inst, Kuwait, Kuwait.
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    Minist Hlth, Thorndon, New Zealand.
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    Karolinska Inst, Stockholm, Sweden.
    Tzourio, Christophe
    Univ Bordeaux, Bordeaux, France.
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    Harvard TH Chan Sch Publ Hlth, Boston, MA USA.
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    Univ Centrooccidental Lisandro Alvarado, Barquisimeto, Venezuela.
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    Med Univ Innsbruck, Innsbruck, Austria.
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    Pontificia Univ Catolica Chile, Santiago, Chile.
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    Cardiovasc Prevent Ctr, Udine, Italy.
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    Norwegian Univ Sci & Technol, Oslo, Norway.
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    Consejeria Sanidad Junta Castilla & Leon, Madrid, Spain.
    Velasquez-Melendez, Gustavo
    Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil.
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    Univ Insubria, Varese, VA, Italy.
    Verschuren, W. M. Monique
    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands.
    Verstraeten, Roosmarijn
    Inst Trop Med, Antwerp, Belgium.
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    Univ Fed Pelotas, Pelotas, RS, Brazil.
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    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands.
    Viikari-Juntura, Eira
    Finnish Inst Occupat Hlth, Helsinki, Finland.
    Vineis, Paolo
    Imperial Coll London, London, England.
    Vioque, Jesus
    Univ Miguel Hernandez, Elche, Spain.
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    Univ Eastern Finland, Kuopio, Finland.
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    INSERM, Paris, France.
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    Minist Hlth, Victoria, Seychelles.
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    North Karelian Ctr Publ Hlth, Joensuu, Finland.
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    Lausanne Univ Hosp, Lausanne, Switzerland.
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    Univ Eastern Finland, Kuopio, Finland.
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    Univ Witwatersrand, Johannesburg, South Africa.
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    Univ Strasbourg, Strasbourg, France.
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    Cork Inst Technol, Cork, Ireland.
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    Univ Sains Malaysia, George Town, Malaysia.
    Mohamud, Wan Nazaimoon Wan
    Inst Med Res, Kuala Lumpur, Malaysia.
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    Univ Pernambuco, Recife, PE, Brazil.
    Wang, Ming-Dong
    Publ Hlth Agcy Canada, Ottawa, ON, Canada.
    Wang, Qian
    Xinjiang Med Univ, Urumqi, Peoples R China.
    Wang, Ya Xing
    Capital Med Univ, Beijing, Peoples R China.
    Wang, Ying-Wei
    Minist Hlth & Welf, Taipei, Taiwan.
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    UCL, London, England.
    Wareham, Nicholas
    Univ Cambridge, Cambridge, England.
    Wedderkopp, Niels
    Univ Southern Denmark, Copenhagen, Denmark.
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    Minist Hlth, Thorndon, New Zealand.
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    St Georges Univ London, London, England.
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    Med Univ Vienna, Vienna, Austria.
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    Univ Indonesia, Depok, Indonesia.
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    Med Univ Silesia, Katowice, Poland.
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    Natl Inst Publ Hlth & Environm, Eindhoven, Netherlands.
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    Univ West Indies, Kingston, Jamaica.
    Willeit, Johann
    Med Univ Innsbruck, Innsbruck, Austria.
    Willeit, Peter
    Med Univ Innsbruck, Innsbruck, Austria;Univ Cambridge, Cambridge, England.
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    Komfo Anokye Teaching Hosp, Kumasi, Ghana.
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    UiT Arctic Univ Norway, Tromso, Norway.
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    Natl Inst Hyg, Natl Inst Publ Hlth, Warsaw, Poland.
    Wong-McClure, Roy A.
    Caja Costarricense Seguro Social, San Jose, Costa Rica.
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    Minist Hlth, Bandar Seri Begawan, Brunei.
    Wong, Tien Yin
    Duke NUS Med Sch, Singapore, Singapore.
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    Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China.
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    Lund Univ, Lund, Sweden.
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    Univ Manchester, Manchester, Lancs, England.
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    Kailuan Gen Hosp, Tangshan, Peoples R China.
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    Minist Agr, Inst Food & Nutr Dev, Beijing, Peoples R China.
    Yan, Weili
    Fudan Univ, Childrens Hosp, Shanghai, Peoples R China.
    Yang, Xiaoguang
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China.
    Ye, Xingwang
    Univ Chinese Acad Sci, Beijing, Peoples R China.
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    Univ Cyprus, Nicosia, Cyprus.
    Yoshihara, Akihiro
    Niigata Univ, Niigata, Japan.
    Younger-Coleman, Novie O.
    Univ West Indies, Kingston, Jamaica.
    Yusoff, Ahmad Faudzi
    Minist Hlth Malaysia, Putra Jaya, Malaysia.
    Zainuddin, Ahmad Ali
    Univ Teknol MARA, Shah Alam, Selangor, Malaysia.
    Zambon, Sabina
    Univ Padua, Padua, Italy.
    Zampelas, Antonis
    Agr Univ Athens, Athens, Greece.
    Zdrojewski, Tomasz
    Med Univ Gdansk, Gdansk, Poland.
    Zeng, Yi
    Peking Univ, Beijing, Peoples R China;Duke Univ, Durham, NC USA.
    Zhao, Dong
    Capital Med Univ, Beijing An Zhen Hosp, Beijing, Peoples R China.
    Zhao, Wenhua
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China.
    Zheng, Wei
    Vanderbilt Univ, Nashville, TN USA.
    Zheng, Yingfeng
    Singapore Eye Res Inst, Singapore, Singapore.
    Zhu, Dan
    Inner Mongolia Med Univ, Hohhot, Peoples R China.
    Zhussupov, Baurzhan
    Kazakh Natl Med Univ, Alma Ata, Kazakhstan.
    Zimmermann, Esther
    Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark.
    Cisneros, Julio Zuniga
    Gorgas Mem Inst Publ Hlth, Panama City, Panama.
    Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants2018Inngår i: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 47, nr 3, s. 872-883iArtikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure.

    Methods

    We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20–29 years to 70–79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probit-transformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure.

    Results

    In 2005–16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the high-income Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association.

    Conclusions

    Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups.

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    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
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    Univ London Imperial Coll Sci Technol & Med, London W2 1PG, England..
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    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
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    Univ London Imperial Coll Sci Technol & Med, London W2 1PG, England..
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    World Hlth Org, Geneva, Switzerland..
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    Emory Univ, Atlanta, GA 30322 USA..
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    Univ Florence, I-50121 Florence, Italy..
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    Univ Fed Pelotas, Pelotas, Brazil..
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    World Hlth Org, Geneva, Switzerland..
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    World Hlth Org, Geneva, Switzerland..
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    Univ Peruana Cayetano Heredia, Lima, Peru..
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    Univ Southern Denmark, Odense, Denmark. Univ Greenland, Manutooq, Greenland..
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    Inst Nacl Salud Publ, Cuernavaca, Morelos, Mexico..
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    World Hlth Org, Reg Off Eastern Mediterranean, Cairo, Egypt.;WHO, Reg Offi Eastern Mediterranean, Cairo, Egypt..
    Ma, Guansheng
    Peking Univ, Beijing, Peoples R China.;Peking Univ, Beijing, Peoples R China..
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    Univ Yaounde I, Yaounde, Cameroon.;Univ Yaounde I, Yaounde, Cameroon..
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    Brown Univ, Providence, RI 02912 USA.;Brown Univ, Providence, RI 02912 USA..
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    Madras Diabet Res Fdn, Madras, Tamil Nadu, India.;Madras Diabet Res Fdn, Madras, Tamil Nadu, India..
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    Istanbul Univ, Istanbul, Turkey.;Istanbul Univ, Istanbul, Turkey..
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    India Diabet Res Fdn, Madras, Tamil Nadu, India.;India Diabet Res Fdn, Delhi, India..
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    Univ Tunis El Manar, Tunis, Tunisia..
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    Univ Calif Berkeley, Berkeley, CA 94720 USA..
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    Univ London Imperial Coll Sci Technol & Med, London W2 1PG, England..
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    Univ London Imperial Coll Sci Technol & Med, London W2 1PG, England..
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    Al Quds Univ, Jerusalem, Israel..
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    Monash Univ Malaysia, Selangor, Malaysia..
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    Birzeit Univ, Birzeit, Israel..
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    Inst Mexicano Seguro Social, Mexico City, DF, Mexico..
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    Univ Adelaide, Adelaide, SA 5005, Australia..
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    Mahidol Univ, Bangkok 10700, Thailand..
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    Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico..
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    Univ Amsterdam, NL-1012 WX Amsterdam, Netherlands..
    Ahmadvand, Alireza
    Noncommunicable Dis Res Ctr, Tehran, Iran..
    Al-Othman, Amani Rashed
    Kuwait Inst Sci Res, Kuwait, Kuwait..
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Luxembourg, Luxembourg..
    Amouyel, Philippe
    Lille Univ & Hosp, Lille, France..
    Amuzu, Antoinette
    London Sch Hyg & Trop Med, London, England..
    Andersen, Lars Bo
    Univ Southern Denmark, Odense, Denmark. Univ Greenland, Manutooq, Greenland..
    Anderssen, Sigmund A.
    Norwegian Sch Sport Sci, Oslo, Norway..
    Anjana, Ranjit Mohan
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India..
    Aounallah-Skhiri, Hajer
    Natl Inst Publ Hlth, Tunis, Tunisia..
    Aris, Tahir
    Minist Hlth Malaysia, Kuala Lumpur, Malaysia..
    Arlappa, Nimmathota
    Indian Council Med Res, New Delhi, India..
    Arveiler, Dominique
    Strasbourg Univ & Hosp, Strasbourg, France..
    Assah, Felix K.
    Univ Yaounde I, Yaounde, Cameroon..
    Avdicova, Maria
    Reg Author Publ Hlth, Banska Bystrica, Slovakia..
    Azizi, Fereidoun
    Shahid Beheshti Univ Med Sci, Tehran, Iran..
    Balakrishna, Nagalla
    Indian Council Med Res, New Delhi, India..
    Bandosz, Piotr
    Med Univ Gdansk, Gdansk, Poland..
    Barbagallo, Carlo M.
    Univ Palermo, I-90133 Palermo, Italy..
    Barcelo, Alberto
    Pan Amer Hlth Org, Washington, DC USA..
    Batieha, Anwar M.
    Jordan Univ Sci & Technol, Amman, Jordan..
    Baur, Louise A.
    Univ Sydney, Sydney, NSW 2006, Australia..
    Benet, Mikhail
    Univ Med Sci, Havana, Cuba..
    Bernabe-Ortiz, Antonio
    Univ Peruana Cayetano Heredia, Lima, Peru..
    Bharadwaj, Sumit
    Chirayu Med Coll, Bhopal, Madhya Pradesh, India..
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    Sunder Lal Jain Hosp, New Delhi, India..
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    Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China..
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    Univ Oslo, N-0316 Oslo, Norway..
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    Univ Oslo, N-0316 Oslo, Norway..
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    Univ Gothenburg, Gothenburg, Sweden..
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    Natl Inst Publ Hlth & Environm, Amsterdam, Netherlands..
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    Univ Turin, I-10124 Turin, Italy..
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    Nanyang Technol Univ, Singapore 639798, Singapore..
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    Ctr Educ Med & Invest Clin, Buenos Aires, DF, Argentina..
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    Minist Hlth, Mahe, Seychelles.;Univ Lausanne, CH-1015 Lausanne, Switzerland..
    Brajkovich, Imperia
    Cent Univ Venezuela, Caracas, Venezuela..
    Breckenkamp, Juergen
    Univ Bielefeld, Bielefeld, Germany..
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    German Canc Res Ctr, Berlin, Germany..
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    Univ Amsterdam, NL-1012 WX Amsterdam, Netherlands..
    Brian, Garry R.
    Fred Hollows Fdn New Zealand, Wellington, New Zealand..
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    Univ Turin, I-10124 Turin, Italy..
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    Univ Southern Denmark, Odense, Denmark. Univ Greenland, Manutooq, Greenland..
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    Univ La Laguna, E-38207 San Cristobal la Laguna, Spain..
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    Istanbul Univ, Istanbul, Turkey..
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    Univ Fed Juiz de Fora, Juiz De Fora, Brazil..
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    Cardiol Mercato S Severino, Milan, Italy..
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    Karolinska Inst, S-10401 Stockholm, Sweden..
    Carvalho, Maria J.
    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
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    Univ Santiago de Compostela, Santiago De Compostela, Spain..
    Casas, Juan-Pablo
    UCL, London WC1E 6BT, England..
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    Assoc Calabrese Epatol, Milan, Italy..
    Castetbon, Katia
    French Inst Hlth Surveillance, Paris, France..
    Chamukuttan, Snehalatha
    India Diabet Res Fdn, Madras, Tamil Nadu, India..
    Chaturvedi, Nishi
    UCL, London WC1E 6BT, England..
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    Acad Sinica, Taipei, Taiwan..
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    Capital Inst Pediat, Beijing, Peoples R China..
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    Kailuan Gen Hosp, Beijing, Peoples R China..
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    Duke NUS Grad Med Sch, Singapore, Singapore..
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    Gertner Inst Epidemiol & Hlth Policy Res, Haifa, Israel..
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    Minist Hlth & Welf, Taipei, Taiwan..
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    Korea Ctr Dis Control & Prevent, Seoul, South Korea..
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    Med Univ Silesia, Poznan, Poland..
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    Charles Univ Prague, Prague, Czech Republic..
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    Katholieke Univ Leuven, Leuven, Belgium..
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    Agcy Prevent & Social Med, Bregenz, Austria..
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    Univ Southampton, Southampton SO9 5NH, Hants, England..
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    UCL, London WC1E 6BT, England..
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    IRCCS Ist Neurol Mediterraneo Neuromed, Milan, Italy..
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    Inst Pasteur, Lille, France..
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    Univ Western Sydney, Penrith, NSW 1797, Australia..
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    CIBEROBN, Barcelona, Spain..
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    CNR, Milan, Italy..
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    Inst Pasteur, Lille, France..
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    Gertner Inst Epidemiol & Hlth Policy Res, Haifa, Israel..
    Dauchet, Luc
    Lille Univ Hosp, Lille, France..
    de Gaetano, Giovanni
    IRCCS Ist Neurol Mediterraneo Neuromed, Milan, Italy..
    De Henauw, Stefaan
    Univ Ghent, B-9000 Ghent, Belgium..
    Deepa, Mohan
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India..
    Dehghan, Abbas
    Erasmus MC, Rotterdam, Netherlands..
    Deschamps, Valerie
    French Inst Hlth Surveillance, Paris, France.;French Inst Hlth Surveillance, Paris, France..
    Dhana, Klodian
    Erasmus MC, Rotterdam, Netherlands..
    Di Castelnuovo, Augusto F.
    IRCCS Ist Neurol Mediterraneo Neuromed, Milan, Italy.;IRCCS Ist Neurol Mediterraneo Neuromed, Milan, Italy..
    Djalalinia, Shirin
    Noncommunicable Dis Res Ctr, Tehran, Iran.;Noncommunicable Dis Res Ctr, Tehran, Iran..
    Doua, Kouamelan
    Minist Sante & Lutte Contre Sida, Abidjan, Cote Ivoire..
    Drygas, Wojciech
    Cardinal Wyszynski Inst Cardiol, Poznan, Poland..
    Du, Yong
    Robert Koch Inst, Berlin, Germany..
    Dzerve, Vilnis
    Latvian State Univ, Riga, Latvia..
    Egbagbe, Eruke E.
    Univ Benin, Benin, Nigeria..
    Eggertsen, Robert
    Univ Gothenburg, Gothenburg, Sweden..
    El Ati, Jalila
    Natl Inst Nutr & Food Technol, Tunis, Tunisia..
    Elosua, Roberto
    Inst Hosp Mar Invest Med, Barcelona, Spain..
    Erasmus, Rajiv T.
    Univ Stellenbosch, ZA-7600 Stellenbosch, South Africa..
    Erem, Cihangir
    Karadeniz Tech Univ, Ankara, Turkey..
    Ergor, Gul
    Dokuz Eylul Univ, TR-35210 Alsancak, Turkey..
    Eriksen, Louise
    Univ So Denmark, Copenhagen, Denmark..
    Escobedo-de la Pena, Jorge
    Inst Mexicano Seguro Social, Mexico City, DF, Mexico..
    Fall, Caroline H.
    Univ Southampton, Southampton SO9 5NH, Hants, England..
    Farzadfar, Farshad
    Univ Tehran Med Sci, Tehran, Iran..
    Felix-Redondo, Francisco J.
    Ctr Salud Villanueva Norte, Barcelona, Spain..
    Ferguson, Trevor S.
    Univ W Indies, Kingston, Jamaica..
    Fernandez-Berges, Daniel
    Hosp Don Benito Villanueva Serena, Barcelona, Spain..
    Ferrari, Marika
    Council Agr Res & Econ, Milan, Italy..
    Ferreccio, Catterina
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Feskens, Edith J. M.
    Wageningen Univ, NL-6700 AP Wageningen, Netherlands..
    Finn, Joseph D.
    Univ Manchester, Manchester M13 9PL, Lancs, England..
    Foeger, Bernhard
    Agcy Prevent & Social Med, Innsbruck, Austria..
    Foo, Leng Huat
    Univ Sains Malaysia, Kuala Lumpur, Malaysia..
    Forslund, Ann-Sofie
    Univ Lulea, S-97187 Lulea, Sweden..
    Francis, Damian K.
    Univ W Indies, Kingston, Jamaica..
    Franco, Maria do Carmo
    Univ Fed Sao Paulo, Sao Paulo, Brazil..
    Franco, Oscar H.
    Erasmus MC, Rotterdam, Netherlands..
    Frontera, Guillermo
    Hosp Univ Son Espases, Barcelona, Spain..
    Furusawa, Takuro
    Kyoto Univ, Kyoto 6068501, Japan..
    Gaciong, Zbigniew
    Med Univ Warsaw, Warsaw, Poland..
    Garnett, Sarah P.
    Univ Sydney, Sydney, NSW 2006, Australia..
    Gaspoz, Jean-Michel
    Univ Hosp Geneva, Geneva, Switzerland..
    Gasull, Magda
    CIBER Epidemiol & Salud Publ, Barcelona, Spain..
    Gates, Louise
    Australian Bur Stat, Melbourne, Vic, Australia..
    Geleijnse, Johanna M.
    Wageningen Univ, NL-6700 AP Wageningen, Netherlands..
    Ghasemian, Anoosheh
    Noncommunicable Dis Res Ctr, Tehran, Iran..
    Ghimire, Anup
    BP Koirala Inst Hlth Sci, Kathmandu, Nepal..
    Giampaoli, Simona
    Ist Super Sanita, Milan, Italy..
    Gianfagna, Francesco
    Univ Insubria, Insubria, Italy..
    Giovannelli, Jonathan
    Lille Univ Hosp, Lille, France..
    Giwercman, Aleksander
    Lund Univ, S-22100 Lund, Sweden..
    Gonzalez Gross, Marcela
    Univ Politecn Madrid, E-28040 Madrid, Spain..
    Gonzalez Rivas, Juan P.
    Andes Clin Cardiometab Studies, Maracaibo, Venezuela..
    Bonet Gorbea, Mariano
    Natl Inst Hyg Epidemiol & Microbiol, Havana, Cuba..
    Gottrand, Frederic
    Univ Lille 2, F-59800 Lille, France..
    Grafnetter, Dusan
    Inst Clin & Expt Med, Prague, Czech Republic..
    Grodzicki, Tomasz
    Jagiellonian Univ, Coll Med, PL-31007 Krakow, Poland..
    Grontved, Anders
    Univ So Denmark, Odense, Denmark..
    Gruden, Grabriella
    Univ Turin, I-10124 Turin, Italy..
    Gu, Dongfeng
    Natl Ctr Cardiovasc Dis, Beijing, Peoples R China..
    Guan, Ong Peng
    Singapore Eye Res Inst, Singapore, Singapore..
    Guerrero, Ramiro
    Univ Icesi, Cali, Colombia..
    Guessous, Idris
    Univ Hosp Geneva, Geneva, Switzerland..
    Guimaraes, Andre L.
    Univ Estadual Montes Claros, Montes Claros, Brazil..
    Gutierrez, Laura
    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina..
    Hambleton, Ian R.
    Univ W Indies, Kingston, Jamaica..
    Hardy, Rebecca
    UCL, London WC1E 6BT, England..
    Kumar, Rachakulla Hari
    Indian Council Med Res, New Delhi, India..
    Hata, Jun
    Kyushu Univ, Fukuoka 812, Japan. Tulane Univ, New Orleans, LA 70118 USA..
    Heidemann, Christin
    Robert Koch Inst, Berlin, Germany..
    Herrala, Sauli
    Oulu Univ Hosp, Oulu, Finland..
    Hihtaniemi, Ilpo Tapani
    Imperial Coll London, London, England..
    Ho, Sai Yin
    Univ Hong Kong, Hong Kong, Peoples R China..
    Ho, Suzanne C.
    Chinese Univ Hong Kong, Hong Kong, Peoples R China..
    Hofman, Albert
    Erasmus MC, Rotterdam, Netherlands..
    Hormiga, Claudia M.
    Fdn Oftalmol Santander, Santander, Spain..
    Horta, Bernardo L.
    Univ Fed Pelotas, Pelotas, Brazil..
    Houti, Leila
    Univ Oran 1, Oran, Algeria..
    Howitt, Christina
    Univ W Indies, Kingston, Jamaica..
    Htay, Thein Thein
    Minist Hlth, Naypyidaw, Myanmar..
    Htet, Aung Soe
    Univ Oslo, N-0316 Oslo, Norway..
    Htike, Maung Maung Than
    Minist Hlth, Naypyidaw, Myanmar..
    Hu, Yang
    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
    Hussieni, Abdullatif S.
    Birzeit Univ, Birzeit, Israel..
    Huybrechts, Inge
    Int Agcy Res Canc, Lyon, France..
    Hwalla, Nahla
    Amer Univ Beirut, Beirut, Lebanon..
    Iacoviello, Licia
    IRCCS Ist Neurol Mediterraneo Neuromed, Milan, Italy..
    Iannone, Anna G.
    Cardiol Mercato S Severino, Milan, Italy..
    Ibrahim, M. Mohsen
    Cairo Univ, Cairo, Egypt..
    Ikeda, Nayu
    Natl Inst Hlth & Nutr, Tokyo, Japan..
    Ikram, M. Arfan
    Erasmus MC, Rotterdam, Netherlands..
    Irazola, Vilma E.
    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina..
    Islam, Muhammad
    Aga Khan Univ, Karachi, Pakistan..
    Iwasaki, Masanori
    Niigata Univ, Niigata 95021, Japan..
    Jacobs, Jeremy M.
    Hadassah Univ, Med Ctr, Jerusalem, Israel..
    Jafar, Tazeen
    Duke NUS Grad Med Sch, Singapore, Singapore..
    Jamil, Kazi M.
    Kuwait Inst Sci Res, Kuwait, Kuwait..
    Jasienska, Grazyna
    Jagiellonian Univ, Coll Med, PL-31007 Krakow, Poland..
    Jiang, Chao Qiang
    Univ Hong Kong, Hong Kong, Peoples R China..
    Jonas, Jost B.
    Heidelberg Univ, Heidelberg, Germany..
    Joshi, Pradeep
    WHO, Country Off, New Delhi, India..
    Kafatos, Anthony
    Univ Crete, Iraklion, Greece..
    Kalter-Leibovici, Ofra
    Gertner Inst Epidemiol & Hlth Policy Res, Jerusalem, Israel..
    Kasaeian, Amir
    Noncommunicable Dis Res Ctr, Tehran, Iran..
    Katz, Joanne
    Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA..
    Kaur, Prabhdeep
    Natl Inst Epidemiol, New Delhi, India..
    Kavousi, Maryam
    Erasmus MC, Rotterdam, Netherlands. Oulu Univ Hosp, Oulu, Finland..
    Kelishadi, Roya
    Res Inst Primordial Prevent Noncommunicable Dis, Tehran, Iran..
    Kengne, Andre P.
    South African Med Res Council, Cape Town, South Africa..
    Kersting, Mathilde
    Res Inst Child Nutr, Dortmund, Germany..
    Khader, Yousef Saleh
    Jordan Univ Sci & Technol, Irbid, Jordan..
    Khalili, Davood
    Shahid Beheshti Univ Med Sci, Tehran, Iran..
    Khang, Young-Ho
    Seoul Natl Univ, Seoul 151, South Korea..
    Kiechl, Stefan
    Med Univ Innsbruck, A-6020 Innsbruck, Austria..
    Kim, Jeongseon
    Natl Canc Ctr, Goyang, South Korea..
    Kolsteren, Patrick
    Inst Trop Med, Antwerp, Belgium. Tartu Univ Clin, Tartu, Estonia..
    Kratzer, Wolfgang
    Univ Hosp Ulm, Ulm, Germany..
    Kromhout, Daan
    Wageningen Univ, NL-6700 AP Wageningen, Netherlands..
    Kujala, Urho M.
    Univ Jyvaskyla, SF-40351 Jyvaskyla, Finland..
    Kula, Krzysztof
    Med Univ Lodz, Lodz, Poland..
    Kyobutungi, Catherine
    African Populat & Hlth Res Ctr, Nairobi, Kenya..
    Laatikainen, Tiina
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Lachat, Carl
    Univ Ghent, B-9000 Ghent, Belgium..
    Laid, Youcef
    INSP, Algiers, Algeria..
    Lam, Tai Hing
    Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China..
    Landrove, Orlando
    Minist Salud Publ, Havana, Cuba..
    Lanska, Vera
    Inst Clin & Expt Med, Prague, Czech Republic..
    Lappas, Georg
    Sahlgrens Acad, Gothenburg, Sweden..
    Laxmaiah, Avula
    Indian Council Med Res, New Delhi, India..
    Leclercq, Catherine
    Food & Agr Org, Rome, Italy..
    Lee, Jeannette
    Natl Univ Singapore, Singapore 117548, Singapore..
    Lee, Jeonghee
    Natl Canc Ctr, Goyang, South Korea..
    Lehtimaki, Terho
    Tampere Univ Hosp, Tampere, Finland..
    Lekhraj, Rampal
    Univ Putra Malaysia, Serdang 43400, Malaysia..
    Leon-Munoz, Luz M.
    Univ Autonoma Madrid, E-28049 Madrid, Spain..
    Li, Yanping
    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
    Lim, Wei-Yen
    Natl Univ Singapore, Singapore 117548, Singapore..
    Fernanda Lima-Costa, M.
    Fundacao Oswaldo Cruz, Rene Rachou Res Inst, Recife, PE, Brazil..
    Lin, Hsien-Ho
    Natl Taiwan Univ, Taipei, Taiwan..
    Lin, Xu
    Univ Chinese Acad Sci, Beijing, Peoples R China..
    Lissner, Lauren
    Univ Gothenburg, Gothenburg, Sweden..
    Lorbeer, Roberto
    Univ Med Greifswald, Greifswald, Germany..
    Eugenio Lozano, Jose
    Consejeria Sanidad Junta Castilla & Leon, Madrid, Spain..
    Luksiene, Dalia
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania..
    Lundqvist, Annamari
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Lytsy, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Machado-Coelho, George L. L.
    Univ Fed Ouro Preto, Ouro Preto, Brazil..
    Machi, Suka
    Jikei Univ, Sch Med, Tokyo, Japan..
    Maggi, Stefania
    CNR, Rome, Italy..
    Magliano, Dianna J.
    Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia..
    Makdisse, Marcia
    Hosp Israelita Albert Einstein, Sao Paulo, Brazil..
    Rao, Kodavanti Mallikharjuna
    Indian Council Med Res, New Delhi, India..
    Manios, Yannis
    Harokopio Univ, Kallithea, Greece..
    Manzato, Enzo
    Univ Padua, I-35100 Padua, Italy..
    Margozzini, Paula
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Marques-Vidal, Pedro
    Univ Lausanne Hosp, Lausanne, Switzerland..
    Martorell, Reynaldo
    Emory Univ, Atlanta, GA 30322 USA..
    Masoodi, Shariq R.
    Sherikashmir Inst Med Sci, Srinagar, Jammu & Kashmir, India..
    Mathiesen, Ellisiv B.
    UiT Arct Univ Norway, Tromso, Norway..
    Matsha, Tandi E.
    Cape Peninsula Univ Technol, Cape Town, South Africa..
    McFarlane, Shelly R.
    Univ W Indies, Kingston, Jamaica..
    McLachlan, Stela
    Univ Edinburgh, Edinburgh EH8 9YL, Midlothian, Scotland..
    McNulty, Breige A.
    Univ Coll Dublin, Dublin 2, Ireland..
    Mediene-Benchekor, Sounnia
    Univ Oran 1, Es Senia, Algeria..
    Meirhaeghe, Aline
    INSERM, F-75654 Paris 13, France..
    Menezes, Ana Maria B.
    Univ Fed Pelotas, Pelotas, Brazil..
    Merat, Shahin
    Digest Dis Res Inst, Tehran, Iran..
    Meshram, Indrapal I.
    Indian Council Med Res, New Delhi, India..
    Mi, Jie
    Capital Inst Pediat, Beijing, Peoples R China..
    Francisco Miquel, Juan
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Jaime Miranda, J.
    Univ Peruana Cayetano Heredia, Lima, Peru..
    Mohamed, Mostafa K.
    Ain Shams Univ, Cairo, Egypt..
    Mohammad, Kazem
    Univ Tehran Med Sci, Tehran, Iran..
    Mohammadifard, Noushin
    Isfahan Cardiovasc Res Ctr, Tehran, Iran..
    Yusoff, Muhammad Fadhli Mohd
    Minist Hlth Malaysia, Kuala Lumpur, Malaysia..
    Moller, Niels C.
    Univ So Denmark, Odense, Denmark..
    Molnar, Denes
    Univ Pecs, Pecs, Hungary..
    Mondo, Charles K.
    Mulago Hosp, Kampala, Uganda..
    Morejon, Alain
    Univ Med Sci, Havana, Cuba..
    Moreno, Luis A.
    Univ Zaragoza, E-50009 Zaragoza, Spain..
    Morgan, Karen
    RCSI Dublin, Dublin, Ireland..
    Moschonis, George
    Harokopio Univ, Kallithea, Greece..
    Mossakowska, Malgorzata
    Int Inst Mol & Cell Biol, Warsaw, Poland..
    Mostafa, Aya
    Ain Shams Univ, Cairo, Egypt..
    Mota, Jorge
    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
    Motta, Jorge
    Gorgas Mem Inst Publ Hlth, Panama City, Panama..
    Mu, Thet Thet
    Dept Publ Hlth, Naypyidaw, Myanmar..
    Muiesan, Maria Lorenza
    Univ Brescia, Brescia, Italy..
    Mueller-Nurasyid, Martina
    Helmholtz Zentrum Munchen, Munich, Germany..
    Mursu, Jaakko
    Univ Eastern Finland, Joensuu, Finland..
    Nagel, Gabriele
    Univ Ulm, D-89069 Ulm, Germany..
    Namesna, Jana
    Reg Author Publ Hlth, Banska Bystrica, Slovakia..
    Nang, Ei Ei K.
    Natl Univ Singapore, Singapore 117548, Singapore..
    Nangia, Vinay B.
    Suraj Eye Inst, Nagpur, Maharashtra, India..
    Maria Navarrete-Munoz, Eva
    CIBER Epidemiol & Salud Publ, Barcelona, Spain..
    Ndiaye, Ndeye Coumba
    INSERM, F-75654 Paris 13, France..
    Nenko, Ilona
    Jagiellonian Univ, Coll Med, PL-31007 Krakow, Poland..
    Nervi, Flavio
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Nguyen, Nguyen D.
    Univ Pharm & Med Ho Chi Minh City, Ho Chi Minh City, Vietnam..
    Nguyen, Quang Ngoc
    Nieto-Martinez, Ramfi S. E.
    Univ Ctr Occidental Lisandro Alvarado, Caracas, Venezuela..
    Ning, Guang
    Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China..
    Ninomiya, Toshiharu
    Kyushu Univ, Fukuoka 812, Japan..
    Noale, Marianna
    CNR, Milan, Italy..
    Noto, Davide
    Univ Palermo, Palermo, Italy..
    Al Nsour, Mohannad
    Eastern Mediterranean Publ Hlth Network, Amman, Jordan..
    Ochoa-Aviles, Angelica M.
    Univ Cuenca, Cuenca, Ecuador..
    Oh, Kyungwon
    Korea Ctr Dis Control & Prevent, Seoul, South Korea..
    Ordunez, Pedro
    Pan Amer Hlth Org, Washington, DC USA..
    Osmond, Clive
    MRC Lifecourse Epidemiol Unit, Southampton, Hants, England..
    Otero, Johanna A.
    Fdn Oftalmol Santander, Santander, Colombia..
    Owusu-Dabo, Ellis
    Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana..
    Pahomova, Elena
    Univ Latvia, Riga, Latvia..
    Palmieri, Luigi
    Ist Super Sanita, Milan, Italy..
    Panda-Jonas, Songhomitra
    Heidelberg Univ, Heidelberg, Germany..
    Panza, Francesco
    Univ Bari, Bari, Italy..
    Parsaeian, Mahboubeh
    Noncommunicable Dis Res Ctr, Tehran, Iran..
    Peixoto, Sergio Viana
    Fundacao Oswaldo Cruz, Rene Rachou Res Inst, Rio De Janeiro, Brazil..
    Peltonen, Markku
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Peters, Annette
    Helmholtz Zentrum Munchen, Munich, Germany..
    Peykari, Niloofar
    Noncommunicable Dis Res Ctr, Tehran, Iran..
    Pham, Son Thai
    Pilav, Aida
    Fed Minist Hlth, Sarajevo, Bosnia & Herceg.;Fed Minist Hlth, Mostar, Bosnia & Herceg..
    Pitakaka, Freda
    Univ New S Wales, Sydney, NSW 2052, Australia..
    Piwonska, Aleksandra
    Cardinal Wyszynski Inst Cardiol, Warsaw, Poland..
    Piwonski, Jerzy
    Cardinal Wyszynski Inst Cardiol, Warsaw, Poland..
    Plans-Rubio, Pedro
    Publ Hlth Agcy Catalonia, Catalonia, Spain..
    Porta, Miquel
    Inst Hosp Mar Invest Med, Madrid, Spain..
    Portegies, Marileen L. P.
    Erasmus MC, Rotterdam, Netherlands..
    Poustchi, Hossein
    Univ Tehran Med Sci, Tehran, Iran..
    Pradeepa, Rajendra
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India..
    Price, Jacqueline F.
    Univ Edinburgh, Edinburgh, Midlothian, Scotland..
    Punab, Margus
    Tartu Univ Clin, Tartu, Estonia..
    Qasrawi, Radwan F.
    Qorbani, Mostafa
    Alborz Univ Med Sci, Alborz, Iran..
    Radisauskas, Ricardas
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania..
    Rahman, Mahmudur
    Raitakari, Olli
    Univ Turku, Turku, Finland..
    Rao, Sudha Ramachandra
    Natl Inst Epidemiol, Delhi, India..
    Ramke, Jacqueline
    Univ New S Wales, Sydney, NSW 2052, Australia..
    Ramos, Rafel
    Inst Univ Invest Atencio Primaria Jordi Gol, Barcelona, Spain..
    Rampal, Sanjay
    Univ Malaya, Kuala Lumpur, Malaysia..
    Rathmann, Wolfgang
    German Diabet Ctr, Berlin, Germany..
    Redon, Josep
    Univ Valencia, Valencia, Spain..
    Reganit, Paul Ferdinand M.
    Univ Philippines, Quezon City 1101, Philippines..
    Rigo, Fernando
    Hlth Ctr San Agustin, San Agustin, Spain..
    Robinson, Sian M.
    Univ Southampton, Southampton SO9 5NH, Hants, England..
    Robitaille, Cynthia
    Publ Hlth Agcy Canada, Toronto, ON, Canada..
    Rodriguez-Artalejo, Fernando
    Univ Autonoma Madrid, Madrid, Spain..
    del Cristo Rodriguez-Perez, Maria
    Rodriguez-Villamizar, Laura A.
    Univ Ind Santander, Santander, Colombia..
    Rojas-Martinez, Rosalba
    Inst Nacl Salud Publ, Mexico City, DF, Mexico..
    Ronkainen, Kimmo
    Rosengren, Annika
    Univ Gothenburg, Gothenburg, Sweden..
    Rubinstein, Adolfo
    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina..
    Rui, Ornelas
    Univ Madeira, Funchal, Portugal..
    Sandra Ruiz-Betancourt, Blanca
    Inst Mexicano Seguro Social, Mexico City, DF, Mexico..
    Russo Horimoto, Andrea R. V.
    Inst Heart, Sao Paulo, Brazil..
    Rutkowski, Marcin
    Med Univ Gdansk, Gdansk, Poland..
    Sabanayagam, Charumathi
    Singapore Eye Res Inst, Singapore, Singapore..
    Sachdev, Harshpal S.
    Sitaram Bhartia Inst Sci & Res, Delhi, India..
    Saidi, Olfa
    Univ Tunis El Manar, Tunis, Tunisia..
    Sakarya, Sibel
    Marmara Univ, Istanbul, Turkey..
    Salanave, Benoit
    French Inst Hlth Surveillance, Paris, France..
    Salonen, Jukka T.
    Univ Helsinki, Helsinki, Finland..
    Salvetti, Massimo
    Univ Brescia, Brescia, Italy..
    Sanchez-Abanto, Jose
    Santos, Diana
    Univ Lisbon, P-1699 Lisbon, Portugal..
    dos Santos, Renata Nunes
    Univ Sao Paulo, Clin Hosp, BR-05508 Sao Paulo, Brazil..
    Santos, Rute
    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
    Saramies, Jouko L.
    Sardinha, Luis B.
    Univ Lisbon, P-1699 Lisbon, Portugal..
    Sarrafzadegan, Nizal
    Isfahan Cardiovasc Res Ctr, Esfahan, Iran..
    Saum, Kai-Uwe
    German Canc Res Ctr, Berlin, Germany..
    Scazufca, Marcia
    Univ Sao Paulo, Clin Hosp, BR-05508 Sao Paulo, Brazil..
    Schargrodsky, Herman
    Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina..
    Scheidt-Nave, Christa
    Robert Koch Inst, Berlin, Germany..
    Sein, Aye Aye
    Sharma, Sanjb K.
    Shaw, Jonathan E.
    Shibuya, Kenji
    Univ Tokyo, Tokyo, Japan..
    Shin, Youchan
    Singapore Eye Res Inst, Singapore, Singapore..
    Shiri, Rahman
    Siantar, Rosalynn
    Singapore Eye Res Inst, Singapore, Singapore..
    Sibai, Abla M.
    Amer Univ Beirut, Beirut, Lebanon..
    Simon, Mary
    Simons, Judith
    Simons, Leon A.
    Univ New S Wales, Sydney, NSW 2052, Australia..
    Sjostrom, Michael
    Karolinska Inst, S-10401 Stockholm, Sweden..
    Slowikowska-Hilczer, Jolanta
    Med Univ Lodz, Lodz, Poland..
    Slusarczyk, Przemyslaw
    Smeeth, Liam
    London Sch Hyg & Trop Med, London, England..
    Snijder, Marieke B.
    Univ Amsterdam, Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands..
    So, Hung-Kwan
    Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China..
    Sobngwi, Eugene
    Univ Yaounde I, Yaounde, Cameroon..
    Soderberg, Stefan
    Umea Univ, Umea, Sweden..
    Solfrizzi, Vincenzo
    Univ Bari, Bari, Italy..
    Sonestedt, Emily
    Lund Univ, Lund, Sweden..
    Soumare, Aicha
    Univ Bordeaux, Bordeaux, France..
    Staessen, Jan A.
    Univ Leuven, Leuven, Belgium..
    Stathopoulou, Maria G.
    INSERM, F-75654 Paris 13, France..
    Steene-Johannessen, Jostein
    Stehle, Peter
    Univ Bonn, Bonn, Germany..
    Stein, Aryeh D.
    Emory Univ, Atlanta, GA 30322 USA..
    Stessman, Jochanan
    Hadassah Univ, Med Ctr, Jerusalem, Israel..
    Stoeckl, Doris
    Helmholtz Zentrum mUNCHEN, Munich, Germany..
    Stokwiszewski, Jakub
    Stronks, Karien
    Univ Amsterdam, Amsterdam, Netherlands..
    Strufaldi, Maria Wany
    Univ Fed Sao Paulo, Sao Paulo, Brazil..
    Sun, Chien-An
    Fu Jen Catholic Univ, Taipei, Taiwan..
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR). Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.
    Sung, Yn-Tz
    Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China..
    Suriyawongpaisal, Paibul
    Mahidol Univ, Bangkok 10700, Thailand..
    Sy, Rody G.
    Univ Philippines, Quezon City 1101, Philippines..
    Tai, E. Shyong
    Natl Univ Singapore, Singapore 117548, Singapore..
    Tamosiunas, Abdonas
    Tang, Line
    Tarawneh, Mohammed
    Tarqui-Mamani, Carolina B.
    Taylor, Anne
    Univ Adelaide, Adelaide, SA 5005, Australia..
    Theobald, Holger
    Karolinska Inst, S-10401 Stockholm, Sweden..
    Thijs, Lutgarde
    Univ Leuven, Leuven, Belgium..
    Thuesen, Betina H.
    Tolonen, Hanna K.
    Tolstrup, Janne S.
    Topbas, Murat
    Torrent, Maties
    Traissac, Pierre
    Trinh, Oanh T. H.
    Univ Pharm & Med Ho Chi Minh City, Ho Chi Minh City, Vietnam..
    Tulloch-Reid, Marshall K.
    Univ W Indies, Kingston, Jamaica..
    Tuomainen, Tomi-Pekka
    Univ Eastern Finland, Joensuu, Finland..
    Turley, Maria L.
    Tzourio, Christophe
    Univ Bordeaux, Bordeaux, France..
    Ueda, Peter
    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
    Ukoli, Flora A. M.
    Meharry Med Coll, Nashville, TN USA..
    Ulmer, Hanno
    Med Univ Innsbruck, A-6020 Innsbruck, Austria..
    Uusitalo, Hannu M. T.
    Tampere Univ Hosp, Tampere, Finland..
    Valdivia, Gonzalo
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Valvi, Damaskini
    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
    van Rossem, Lenie
    Univ Med Ctr Utrecht, Utrecht, Netherlands..
    van Valkengoed, Irene G. M.
    Univ Amsterdam, Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands..
    Vanderschueren, Dirk
    Katholieke Univ Leuven, Leuven, Belgium..
    Vanuzzo, Diego
    Ctr Prevenz Cardiovasc Udine, Udine, Italy..
    Vega, Tomas
    Consejeria Sanidad Junta Castilla & Leon, Leon, Spain..
    Velasquez-Melendez, Gustavo
    Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil..
    Veronesi, Giovanni
    Univ Insubria, Insubria, Italy..
    Verschuren, W. M. Monique
    Natl Inst Publ Hlth & Environm, Amsterdam, Netherlands..
    Verstraeten, Roosmarijn
    Inst Trop Med, Brussels, Belgium..
    Viet, Lucie
    Natl Inst Publ Hlth & Environm, Amsterdam, Netherlands..
    Vioque, Jesus
    Univ Miguel Hernandez, Elche, Spain..
    Virtanen, Jyrki K.
    Univ Eastern Finland, Joensuu, Finland. INSERM, F-75654 Paris 13, France..
    Viswanathan, Bharathi
    Minist Hlth, Victoria, Seychelles..
    Vollenweider, Peter
    Univ Lausanne Hosp, Lausanne, Switzerland..
    Voutilainen, Sari
    Univ Eastern Finland, Tampere, Finland..
    Vrijheid, Martine
    Ctr Res Environm Epidemiol, Barcelona, Spain..
    Wade, Alisha N.
    Univ Witwatersrand, ZA-2050 Johannesburg, South Africa..
    Wagner, Aline
    Univ Strasbourg, Strasbourg, France..
    Walton, Janette
    Univ Coll Cork, Cork, Ireland..
    Mohamud, Wan Nazaimoon Wan
    Inst Med Res, Kuala Lumpur, Malaysia..
    Wang, Feng
    Peking Univ, Hosp 6, Beijing, Peoples R China..
    Wang, Ming-Dong
    Publ Hlth Agcy Canada, Toronto, ON, Canada..
    Wang, Qian
    Xinjiang Med Univ, Urumqi, Xinjiang, Peoples R China..
    Wang, Ya Xing
    Beijing Tongren Hosp, Beijing, Peoples R China..
    Wannamethee, S. Goya
    UCL, London WC1E 6BT, England..
    Weerasekera, Deepa
    Minist Hlth, Auckland, New Zealand..
    Whincup, Peter H.
    St Georges Univ London, London, England..
    Widhalm, Kurt
    Med Univ Vienna, Vienna, Austria. Med Univ Silesia, Katowice, Poland. Natl Inst Publ Hlth & Environm, Amsterdam, Netherlands..
    Wijga, Alet H.
    Wilks, Rainford J.
    Univ W Indies, Kingston, Jamaica..
    Willeit, Johann
    Med Univ Innsbruck, A-6020 Innsbruck, Austria..
    Wilsgaard, Tom
    UiT Arct Univ Norway, Oslo, Norway..
    Wojtyniak, Bogdan
    Natl Inst Hyg, Warsaw, Poland..
    Wong, Tien Yin
    Duke NUS Grad Med Sch, Singapore, Singapore..
    Woo, Jean
    Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China..
    Woodward, Mark
    Univ Sydney, Sydney, NSW 2006, Australia.;Univ Oxford, Oxford, England..
    Wu, Frederick C.
    Univ Manchester, Manchester, Lancs, England..
    Wu, Shou Ling
    Kailuan Gen Hosp, Tangshan, Peoples R China..
    Xu, Haiquan
    Minist Agr, Inst Food & Nutr Dev, Beijing, Peoples R China..
    Yan, Weili
    Fudan Univ, Shanghai, Peoples R China..
    Yang, Xiaoguang
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Ye, Xingwang
    Univ Chinese Acad Sci, Beijing, Peoples R China..
    Yoshihara, Akihiro
    Niigata Univ, Niigata 95021, Japan..
    Younger-Coleman, Novie O.
    Univ W Indies, Kingston, Jamaica..
    Zambon, Sabina
    Univ Padua, Padua, Italy..
    Zargar, Abdul Hamid
    Ctr Diabet & Endocrine Care, New Delhi, India..
    Zdrojewski, Tomasz
    Med Univ Gdansk, Gdansk, Poland..
    Zhao, Wenhua
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Zheng, Yingfeng
    Singapore Eye Res Inst, Singapore, Singapore..
    Zuniga Cisneros, Julio
    Gorgas Mem Inst Publ Hlth, Panama City, Panama..
    Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants2016Inngår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 387, nr 10027, s. 1513-1530Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. Methods We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. Findings We used data from 751 studies including 4 372 000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-7.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target. Interpretation Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults affected, has increased faster in low-income and middle-income countries than in high-income countries. Funding Wellcome Trust.

  • 280.
    Ärnlöv, Johan
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Carlsson, Axel C
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Ingelsson, Erik
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Larsson, Tobias E
    Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community2013Inngår i: Kidney International, ISSN 0085-2538, E-ISSN 1523-1755, Vol. 83, nr 1, s. 160-166Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Fibroblast growth factor-23 (FGF23), a regulator of mineral metabolism, has been linked to cardiovascular disease in chronic kidney disease. As community-based data of the longitudinal association between FGF23 and cardiovascular events are lacking, we investigated a possible relationship in 727 men of the Uppsala Longitudinal Study of Adult Men population-based cohort (mean age 77 years). During a median follow-up of 9.7 years, 110 participants died of cardiovascular causes. In Cox regression models adjusted for age and established cardiovascular risk factors, higher serum FGF23 was associated with a significantly increased risk for cardiovascular mortality (hazard ratio (HR) per increased s.d. of 1.36). This relationship remained significant, albeit attenuated, after adjustment for glomerular filtration rate (GFR) (HR 1.21). FGF23 was also associated with all-cause mortality, although the association was weaker than that with cardiovascular mortality, and it was nonsignificant in fully adjusted multivariate models. Spline analysis suggested a log-linear relationship between FGF23 and outcome. Participants with a combination of high FGF23 (>60 pg/ml), low GFR (<60 ml/min), and micro-/macro-albuminuria (albumin/creatinine ratio above 3 mg/ml) had an almost eightfold increased risk compared with participants without these abnormalities. Thus, a higher FGF23 level is associated with an increased cardiovascular mortality risk in the community. Clinical trials are needed to determine whether FGF23 is a modifiable risk factor.

  • 281.
    Ärnlöv, Johan
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Ingelsson, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Carrero, J. J.
    Karolinska Inst, Stockholm, Sweden..
    Gustafsson, Stefan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Stenemo, Markus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi.
    Larsson, A.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Carlsson, A. C.
    Karolinska Inst, Stockholm, Sweden..
    Discovery and replication of new risk markers for 5-year kidney function decline using a targeted multiplex proteomics chip2016Konferansepaper (Fagfellevurdert)
  • 282.
    Ärnlöv, Johan
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Ingelsson, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men2010Inngår i: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 121, nr 2, s. 230-236Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The purpose of this study was to investigate associations between combinations of body mass index (BMI) categories and metabolic syndrome (MetS) and the risk of cardiovascular disease and death in middle-aged men. METHODS AND RESULTS: At age 50 years, cardiovascular risk factors were assessed in 1758 participants without diabetes in the community-based Uppsala Longitudinal Study of Adult Men (ULSAM). According to BMI-MetS status, they were categorized as normal weight (BMI <25 kg/m(2)) without MetS (National Cholesterol Education Program criteria; n=891), normal weight with MetS (n=64), overweight (BMI 25 to 30 kg/m(2)) without MetS (n=582), overweight with MetS (n=125), obese (BMI >30 kg/m(2)) without MetS (n=30), or obese with MetS (n=66). During follow-up (median 30 years), 788 participants died, and 681 developed cardiovascular disease (composite of cardiovascular death or hospitalization for myocardial infarction, stroke, or heart failure). In Cox proportional-hazards models that adjusted for age, smoking, and low-density lipoprotein cholesterol, an increased risk for cardiovascular disease was observed in normal-weight participants with MetS (hazard ratio 1.63, 95% confidence interval 1.11 to 2.37), overweight participants without MetS (hazard ratio 1.52, 95% confidence interval 1.28 to 1.80), overweight participants with MetS (hazard ratio 1.74, 95% confidence interval 1.32 to 2.30), obese participants without MetS (hazard ratio 1.95, 95% confidence interval 1.14 to 3.34), and obese participants with MetS (hazard ratio 2.55, 95% confidence interval 1.81 to 3.58) compared with normal-weight individuals without MetS. These BMI-MetS categories significantly predicted total mortality rate in a similar pattern. CONCLUSIONS: Middle-aged men with MetS had increased risk for cardiovascular events and total death regardless of BMI status during more than 30 years of follow-up. In contrast to previous reports, overweight and obese individuals without MetS also had an increased risk. The present data refute the notion that overweight and obesity without MetS are benign conditions.

  • 283.
    Ärnlöv, Johan
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Ingelsson, Erik
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Response to Letters Regarding Article, "The Impact of Body Mass Index and the Metabolic Syndrome on the Risk of Cardiovascular Disease and Death in Middle-Aged Men"2010Inngår i: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 122, nr 11, s. E457-E457Artikkel i tidsskrift (Fagfellevurdert)
  • 284.
    Ärnlöv, Johan
    et al.
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Lind, Lars
    Institutionen för medicinska vetenskaper.
    Sundström, Johan
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap. Institutionen för medicinska vetenskaper.
    Andren, Bertil
    Institutionen för medicinska vetenskaper.
    Vessby, Bengt
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Lithell, Hans
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Insulin resistance, dietary fat intake and blood pressure predict left ventricular diastolic function 20 years later.2005Inngår i: Nutr Metab Cardiovasc Dis, ISSN 0939-4753, Vol. 15, nr 4, s. 242-9Artikkel i tidsskrift (Fagfellevurdert)
  • 285.
    Ärnlöv, Johan
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.