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  • 252251.
    Öhrberg, Ann
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature.
    Fischer, Otto
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature.
    Mattson, Annie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature.
    Berndtsson, Tim
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature.
    Inledning: 1700-talets handskriftskulturer2017In: Sjuttonhundratal, ISSN 1652-4772, Vol. 14, p. 8-16Article in journal (Other academic)
  • 252252.
    Öhrberg, Ann
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Literature.
    Fischer, Otto
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Literature.
    Mehrens, Patrik
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Literature.
    Inledning2005In: Tidskrift för litteraturvetenskap: Temanummer: Retorik och litteratur, no 1-2, p. 5-9Article in journal (Refereed)
  • 252253.
    Öhrberg, Ann
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature.
    Heggestad, EvaUppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature.Williams, AnnaUppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature.
    Fält i förvandling: Genusvetenskaplig litteraturförskning2013Collection (editor) (Other academic)
  • 252254.
    Öhrling, Hans
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    Nästa Strängnäs - Slutstation!: En järnväg för vem?2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Strängnäs finally got its rail service in 1895. Enthusiasts as Bishop Thore Strömberg had not, despite twenty of work years, found enough support for the idea until then.

    Lake systems were important for transports in Sweden in this period and which of the two systems, canals or railways, that was preferable was not obvious.

    For residents in Strängnäs the lake of Mälaren offered good opportunities for travelling and transport during this period, at least during the ice-free season.

    The railway-question in Strängnäs may be seen in five periods: First from 1850 to 1870, the second from 1870 to 1880, the third 1881-1888, the fourth 1889-1889 and the last and fifth 1890-1895.

    Finally on September 30, 1895 a railway track could be open between Strängnäs and Åker styckebruk, inaugurated by King Oscar II.

  • 252255.
    Öhrlund, Isak
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    EXPLORING THE POTENTIAL IMPLICATIONS OF HAVING BOTH RETAIL AND DISTRIBUTION PRICE SIGNALS FOR DEMAND RESPONSE IN A DEREGULATED ELECTRICITY MARKET2016Conference paper (Refereed)
    Abstract [en]

    As the share of weather-dependent generation and the electrification of products increase, new challenges arise as supply and demand of electricity becomes more variable and the balance between them more difficult to manage. A system where demand adapts to the available supply has been envisioned as part of the solution to this problem, and price signals that can incentivize such system are under constant development. 

    In markets with retail competition, where the distribution and sales of electricity are separated, consumers may be faced with multiple price signals. Inconsistencies between these signals could in theory distort the incentives for demand response and demand side management. We explore this issue by investigating how hourly retail supply contracts and time-of-use distribution network tariffs may vary in relation to each other, and how appropriate hourly retail supply contracts are to use as a signal for demand response in local distribution networks. 

    Our analyses show that the incentives for demand response provided by a time-of-use distribution tariff counteracts the incentives given by hourly retail supply contracts in a substantial proportion of the hours over a year. The extent of this counteraction is more severe for consumers who have less possibilities to engage in demand response over the course of a day e.g. due to a lack of technical solutions for scheduling their consumption. Our results also indicate that the hourly wholesale price of electricity may be inappropriate as an incentive for demand response from a local distribution network balancing perspective. We conclude that if distribution tariffs and retail supply contracts are to properly incentivize demand response they need to be more coherent and better reflect the actual situation in the local distribution network.

  • 252256.
    Öhrlund, Isak
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Insamling av elektriskt och elektroniskt avfall: En fallstudie av två svenska kommuner2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Waste electrical and electronic equipment (WEEE) is the fastest growing waste stream within the EU, and at the same time of the most hazardous forms of waste, threatening both human health and the environment if not properly collected and treated. Sweden started a separate collection of WEEE in 2001, and with 16,27 kg of WEEE collected per person in 2011 it has one of the highest collection rates within the EU. Despite this, small WEEE is still ending up in all types of household waste. To solve this issue, the need for increased availability of collections points and information is frequently discussed, but despite improvements in these areas the content of WEEE in household waste remains relatively stable. The studies that make up the basis of today’s improvement work, have either been looking at shortcomings of the collection system from a national point of view, or on the effectiveness of alternative local collection systems. Based on these studies, conclusions about the general shortcomings of the system and potential ways of improvement have been drawn. At the same time, statistics show that the collection of WEEE differs substantially between different parts of Sweden, and that some municipalities have surprisingly efficient collection systems compared to others. With regard to his, current improvement strategies may not be optimal.

    Instead of looking at the strengths and weaknesses of specific collection systems, this study looks at the differences between two Swedish municipalities, one with a high and one with a low collection rate of small WEEE and compact fluorescent lamps, with the aim of creating a better understanding of factors that may contribute to high collection rates. The differences that are studied are the availability of collection points and the information in connection to these, the municipalities’ work and the resident’s knowledge, attitudes, preferences, subjective behavior and subjective perception of the collection system’s availability and functionality. Furthermore, the thesis examines whether the residents have been informed in accordance with European and national WEEE-legislation and what their attitudes and preferences are regarding a potential deposit system for small WEEE and compact fluorescent lamps.

    The results show that differences can be seen in all areas but the residents’ knowledge. From the observed differences, conclusions about possible ways of improving the collection of WEEE in Sweden are drawn. On a local level, increased municipal engagement and work efforts, in combination with increased access to collection points along with appropriate and well customized information in connection to these, is likely to increase the collection of WEEE. On a national level, increased supervision that forces municipalities to comply with the information requirements in European and national legislation, may lead to an increased awareness among Swedish citizens, which may in turn lead to a decrease in wrongly sorted small WEEE and compact fluorescent lamps. Finally, a potential deposit system for small WEEE and compact fluorescent lamps may be yet another way of increasing collection rates. The results suggest that a deposit system may in fact increase the motivation of citizens to recycle these products, decrease the amount of old electrical and electronic equipment currently stockpiled in private households, offer new possibilities to mark and track products and potentially lower the costs of collection.

  • 252257.
    Öhrlund, Isak
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Linné, Åse
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Bartusch, Cajsa
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Convenience before coins: Household responses to dual dynamic price signals and energy feedback in Sweden2019In: Energy Research & Social Science, ISSN 2214-6296, E-ISSN 2214-6326, Vol. 52, p. 236-246Article in journal (Refereed)
    Abstract [en]

    To enable and cope with an increase of intermittent electricity generation, the power industry and regulators are trying to incentivise users to use electricity at certain times through dynamic pricing and feedback. The effects of such interventions on patterns of electricity use have been extensively studied, yet little is known about how and why householders do or do not respond to such interventions. Using interviews and activity-based diaries, this study provides a qualitative exploration of how and why householders who are subject to a demand-based time-of-use distribution tariff, real-time retail pricing and real-time feedback, do or do not respond to such interventions in their daily lives. We find that the householders have adapted a range of existing practices and have started to engage in new ones that aim to reduce peak demand during peak hours, partly without the support of feedback. Drawing on theories of practice, we challenge common preconceptions about how and why price signals work by demonstrating how the size of the financial incentive that a price signal provides does not have that much influence on householders’ willingness to engage in demand response. We argue that price signals work by providing new meanings to practices that use electricity, that feedback can mediate these meanings, and that what matters for householders’ willingness to engage in demand response is that the changes they undertake do not cause them any inconvenience by limiting the temporal flexibility of other doings in their daily lives.

  • 252258.
    Öhrlund, Isak
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Schultzberg, Mårten
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    Bartusch, Cajsa
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Identifying and estimating the effects of a mandatory billing demand charge2019In: Applied Energy, ISSN 0306-2619, E-ISSN 1872-9118, Vol. 237, p. 885-895Article in journal (Refereed)
    Abstract [en]

    As peak demand for electricity continues to rise, distributors have begun charging small and medium-sized users for their short term demand rather than just their energy use. This is not only to meet the political aspirations for increased demand-side flexibility that now exist in many corners of the world, but to make sure that users are charged for the costs they incur. As it is only until recently that this type of users have come to face demand charges, there are however very few studies on what the actual effects of such pricing policies are, and those studies that do exist suffer from different methodological shortcomings that reduce their validity as a basis for real-world policy evaluations. This study provides the first state-of-the-art causal analysis of the demand response effects of a billing demand charge involuntarily introduced to small and medium sized users (35–63 A), using novel two-level time series models on retrospective observational consumption and survey data. Our analyses suggest that the tariff has induced an average response of −0.32 kWh/day per user over a two year long posttreatment period in comparison to a matched control group, equal to 7.4% of their daily average use during the pretreatment period. The response seems to have increased over time and to be greater during wintertime: around −0.70 kWh/day or 16.2% of the treated users’ average daily use during the pretreatment period. Comparing the individual users’ response to the size of their financial incentive to respond given the new tariff as well as their self-reported perception of the relative importance of electricity expenditures, we did not find any support for the common assumption that users with a higher financial incentive to respond do so to a greater extent. This might suggest that small and medium-sized commercial users, just as residential users, may exhibit non-financial drivers and barriers for engaging in demand response that may be vital to understand as policy makers and industry continue to seek increased demand-side flexibility.

  • 252259.
    Öhrlund, Åke
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Analytisk kemi.
    The Use of ESCA for Chemical Characterization of Organically Modified Surfaces2001Licentiate thesis, monograph (Other scientific)
  • 252260.
    Öhrmalm, Christina
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Functional Characterization of the Cellular Protein p32: A Protein Regulating Adenovirus Transcription and Splicing Through Targeting of Phosphorylation2006Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Cellular processes involved in the conversion of the genetic information from DNA into a protein are often regulated by reversible phosphorylation reactions. By modulating the phosphorylated status of key proteins their activity can either be enhanced or repressed. In this thesis I have studied the significance of phosphorylation in the regulation of transcription and splicing using human adenovirus as a model system.

    The results show that the activity of the cellular SR family of splicing enhancer or repressor proteins are reduced in adenovirus infected nuclear extracts by a virus-induced hypophosphorylation. The viral E4-ORF4 was shown to induce SR protein dephosphorylation by recruiting the cellular protein phosphatase PP2A. The E4-ORF4/PP2A complex was shown to relieve the SR protein-mediated repression of late virus-specific splicing and further activate alternative splicing in transiently transfected cells. Collectively, these results showed that alternative splicing, like many other biological processes, is regulated by reversible protein phosphorylation.

    Similarly, the cellular p32 protein was shown to cause hypophosphorylation of the SR protein ASF/SF2 resulting in a reduced RNA binding capacity of ASF/SF2. This change in ASF/SF2 RNA binding also had a drastic effect on the function of ASF/SF2 as a regulatory protein affecting splice site choice. The cellular p32 protein and the viral E4-ORF4 protein both target the same cellular splicing factor, ASF/SF2. However, they regulate splicing by different mechanisms. E4-ORF4 recruits a phosphatase to dephosphorylate ASF/SF2, while p32 sequester ASF/SF2 in an inactive complex.

    Further, we demonstrated that overexpression of p32 during a lytic infection suppressed transcription from the adenovirus major late transcription unit. p32 induced a selective repression of CAAT-box containing promoters indicating the involvement of the transcription factor CBF/NF-Y in this regulation. A further analysis showed that p32 caused a hyperphosphorylation of the CTD of RNA Pol II, which resulted in a significant reduction in the processivity of Pol II during the elongation phase of transcription.

    In summary, we have shown that E4-ORF4 regulates the activity of splicing regulatory SR proteins, and that p32 regulates the activity of the SR protein ASF/SF2 in splicing and Pol II processivity during transcription elongation. Mechanistically, both E4-ORF4 and p32 appears to function by regulating the phosphorylated status of key cellular proteins involved in these processes.

    List of papers
    1. Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins
    Open this publication in new window or tab >>Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins
    Show others...
    1998 (English)In: Nature, ISSN 0028-0836, Vol. 393, p. 185-187Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-94320 (URN)
    Available from: 2006-04-20 Created: 2006-04-20 Last updated: 2011-06-30Bibliographically approved
    2. The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phophorylation
    Open this publication in new window or tab >>The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phophorylation
    Show others...
    1999 (English)In: EMBO Journal, Vol. 18, no 4, p. 1014-1024Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-94321 (URN)
    Available from: 2006-04-20 Created: 2006-04-20 Last updated: 2011-06-30Bibliographically approved
    3. Identification of a carboxy-terminal sequence in the splicing factor-associated protein p32, necessary for p32-mediated inhibition of ASF/SF2 RNA binding
    Open this publication in new window or tab >>Identification of a carboxy-terminal sequence in the splicing factor-associated protein p32, necessary for p32-mediated inhibition of ASF/SF2 RNA binding
    (English)Manuscript (Other academic)
    Identifiers
    urn:nbn:se:uu:diva-94322 (URN)
    Available from: 2006-04-20 Created: 2006-04-20 Last updated: 2011-06-30Bibliographically approved
    4. Cellular splicing and transcription regulatory protein p32 represses adenovirus major late transcription and causes hyperphosphorylation of RNA polymerase II
    Open this publication in new window or tab >>Cellular splicing and transcription regulatory protein p32 represses adenovirus major late transcription and causes hyperphosphorylation of RNA polymerase II
    2006 (English)In: Journal of Virology, ISSN 0022-538X, E-ISSN 1098-5514, Vol. 80, no 10, p. 5010-5020Article in journal (Refereed) Published
    Abstract [en]

    The cellular protein p32 is a multifunctional protein, which has been shown to interact with a large number of cellular and viral proteins and to regulate several important activities like transcription and RNA splicing. We have previously shown that p32 regulates RNA splicing by binding and inhibiting the essential SR protein ASF/SF2. To determine whether p32 also functions as a regulator of splicing in virus-infected cells, we constructed a recombinant adenovirus expressing p32 under the transcriptional control of an inducible promoter. Much to our surprise the results showed that p32 overexpression effectively blocked mRNA and protein expression from the adenovirus major late transcription unit (MLTU). Interestingly, the p32-mediated inhibition of MLTU transcription was accompanied by an approximately 4.5-fold increase in Ser 5 phosphorylation and an approximately 2-fold increase in Ser 2 phosphorylation of the carboxy-terminal domain (CTD). Further, in p32-overexpressing cells the efficiency of RNA polymerase elongation was reduced approximately twofold, resulting in a decrease in the number of polymerase molecules that reached the end of the major late L1 transcription unit. We further show that p32 stimulates CTD phosphorylation in vitro. The inhibitory effect of p32 on MLTU transcription appears to require the CAAT box element in the major late promoter, suggesting that p32 may become tethered to the MLTU via an interaction with the CAAT box binding transcription factor.

    Keywords
    Adenoviridae/*genetics/*metabolism, Carrier Proteins/biosynthesis/genetics/*physiology, Cell Line, DNA Replication/physiology, Humans, Mitochondrial Proteins/biosynthesis/genetics/*physiology, NFI Transcription Factors/genetics/physiology, Phosphorylation, Promoter Regions (Genetics), RNA Polymerase II/antagonists & inhibitors/*metabolism, Recombination; Genetic, Repressor Proteins/biosynthesis/genetics/*physiology, Tetracycline/pharmacology, Transcription; Genetic/*physiology
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-94323 (URN)10.1128/JVI.80.10.5010-5020.2006 (DOI)16641292 (PubMedID)
    Available from: 2006-04-20 Created: 2006-04-20 Last updated: 2017-12-14Bibliographically approved
  • 252261.
    Öhrmalm, Christina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Akusjärvi, Göran
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Cellular splicing and transcription regulatory protein p32 represses adenovirus major late transcription and causes hyperphosphorylation of RNA polymerase II2006In: Journal of Virology, ISSN 0022-538X, E-ISSN 1098-5514, Vol. 80, no 10, p. 5010-5020Article in journal (Refereed)
    Abstract [en]

    The cellular protein p32 is a multifunctional protein, which has been shown to interact with a large number of cellular and viral proteins and to regulate several important activities like transcription and RNA splicing. We have previously shown that p32 regulates RNA splicing by binding and inhibiting the essential SR protein ASF/SF2. To determine whether p32 also functions as a regulator of splicing in virus-infected cells, we constructed a recombinant adenovirus expressing p32 under the transcriptional control of an inducible promoter. Much to our surprise the results showed that p32 overexpression effectively blocked mRNA and protein expression from the adenovirus major late transcription unit (MLTU). Interestingly, the p32-mediated inhibition of MLTU transcription was accompanied by an approximately 4.5-fold increase in Ser 5 phosphorylation and an approximately 2-fold increase in Ser 2 phosphorylation of the carboxy-terminal domain (CTD). Further, in p32-overexpressing cells the efficiency of RNA polymerase elongation was reduced approximately twofold, resulting in a decrease in the number of polymerase molecules that reached the end of the major late L1 transcription unit. We further show that p32 stimulates CTD phosphorylation in vitro. The inhibitory effect of p32 on MLTU transcription appears to require the CAAT box element in the major late promoter, suggesting that p32 may become tethered to the MLTU via an interaction with the CAAT box binding transcription factor.

  • 252262.
    Öhrmalm, Christina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Akusjärvi, Göran
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Identification of a carboxy-terminal sequence in the splicing factor-associated protein p32, necessary for p32-mediated inhibition of ASF/SF2 RNA bindingManuscript (Other academic)
  • 252263.
    Öhrmalm, Christina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Virology.
    Eriksson, Ronnie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Virology.
    Jobs, Magnus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Virology.
    Simonson, Magnus
    Naitonal Food Agency, Uppsala.
    Strømme, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Bondeson, Kåre
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Virology.
    Herrmann, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Bacteriology.
    Melhus, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Bacteriology.
    Blomberg, Jonas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Virology.
    Variation-tolerant capture and multiplex detection of nucleic acids: application to detection of microbes2012In: Journal of Clinical Microbiology, ISSN 0095-1137, E-ISSN 1098-660X, Vol. 50, no 10, p. 3208-3215Article in journal (Refereed)
    Abstract [en]

    In contrast to ordinary PCRs, which have a limited multiplex capacity and often return false-negative results due to target variation or inhibition, our new detection strategy, VOCMA (variation-tolerant capture multiplex assay), allows variation-tolerant, target-specific capture and detection of many nucleic acids in one test. Here we demonstrate the use of a single-tube, dual-step amplification strategy that overcomes the usual limitations of PCR multiplexing, allowing at least a 22-plex format with retained sensitivity. Variation tolerance was achieved using long primers and probes designed to withstand variation at known sites and a judicious mix of degeneration and universal bases. We tested VOCMA in situations where enrichment from a large sample volume with high sensitivity and multiplexity is important (sepsis; streptococci, enterococci, and staphylococci, several enterobacteria, candida, and the most important antibiotic resistance genes) and where variation tolerance and high multiplexity is important (gastroenteritis; astrovirus, adenovirus, rotavirus, norovirus genogroups I and II, and sapovirus, as well as enteroviruses, which are not associated with gastroenteritis). Detection sensitivities of 10 to 1,000 copies per reaction were achieved for many targets. VOCMA is a highly multiplex, variation-tolerant, general purpose nucleic acid detection concept. It is a specific and sensitive method for simultaneous detection of nucleic acids from viruses, bacteria, fungi, and protozoa, as well as host nucleic acid, in the same test. It can be run on an ordinary PCR and a Luminex machine and is suitable for both clinical diagnoses and microbial surveillance.

  • 252264.
    Öhrmalm, Christina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Jobs, Magnus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Virology.
    Eriksson, Ronnie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Golbob, Sultan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Elfaitouri, Amal
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Benachenhou, Farid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Strømme, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Blomberg, Jonas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Virology.
    Hybridization properties of long nucleic acid probes for detection of variable target sequences, and development of a hybridization prediction algorithm2010In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, Vol. 38, no 21, p. e195-Article in journal (Refereed)
    Abstract [en]

    One of the main problems in nucleic acid-based techniques for detection of infectious agents, such as influenza viruses, is that of nucleic acid sequence variation. DNA probes, 70-nt long, some including the nucleotide analog deoxyribose-Inosine (dInosine), were analyzed for hybridization tolerance to different amounts and distributions of mismatching bases, e.g. synonymous mutations, in target DNA. Microsphere-linked 70-mer probes were hybridized in 3M TMAC buffer to biotinylated single-stranded (ss) DNA for subsequent analysis in a Luminex® system. When mismatches interrupted contiguous matching stretches of 6 nt or longer, it had a strong impact on hybridization. Contiguous matching stretches are more important than the same number of matching nucleotides separated by mismatches into several regions. dInosine, but not 5-nitroindole, substitutions at mismatching positions stabilized hybridization remarkably well, comparable to N (4-fold) wobbles in the same positions. In contrast to shorter probes, 70-nt probes with judiciously placed dInosine substitutions and/or wobble positions were remarkably mismatch tolerant, with preserved specificity. An algorithm, NucZip, was constructed to model the nucleation and zipping phases of hybridization, integrating both local and distant binding contributions. It predicted hybridization more exactly than previous algorithms, and has the potential to guide the design of variation-tolerant yet specific probes.

  • 252265.
    Öhrmalm, L.
    et al.
    Karolinska Univ Hosp, Karolinska Inst, Ctr Mol Med, Dept Med,Infect Dis Unit, Solna, Sweden..
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Wong, M.
    Karolinska Univ Hosp, Karolinska Inst, Ctr Mol Med, Dept Med,Infect Dis Unit, Solna, Sweden..
    Levinson, P.
    Karolinska Univ Hosp, Karolinska Inst, Ctr Mol Med, Dept Med,Infect Dis Unit, Solna, Sweden..
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
    Broliden, K.
    Karolinska Univ Hosp, Karolinska Inst, Ctr Mol Med, Dept Med,Infect Dis Unit, Solna, Sweden..
    Alving, Kjell
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
    Presence of rhinovirus in the respiratory tract of adolescents and young adults with asthma without symptoms of infection2016In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 115, p. 1-6Article in journal (Refereed)
    Abstract [en]

    Background: Viral respiratory infections have been associated with up to 80% of wheezing episodes and asthma exacerbations. However, studies on the role of these viruses in asthmatic patients in the interval between exacerbations are sparse. This study aimed to determine the presence of respiratory viruses, without symptoms of infection, in the airways of young asthmatics as compared to healthy controls.

    Material and Methods: Patients 10-35 years of age with stable asthma and a group of healthy controls were analyzed regarding the presence of RNA from common respiratory viruses in nasopharyngeal aspirates by PCR. Self-reported asthma control and quality of life, fraction of exhaled nitric oxide (FeNO), spirometry, and bronchial responsiveness to methacholine were recorded. Blood samples were collected to assess IgE sensitisation and eosinophil cationic protein (ECP) levels.

    Results: In 354 patients with asthma and 108 healthy controls, human rhinovirus (HRV) was the only virus detected (4.5% of asthmatics vs. 0.9% of controls; p = 0.08). HRV+ asthma patients had a higher degree of aeroallergen IgE sensitisation (median 37.7 vs. 10.4 kU(A)/L, p = 0.04), and a tendency for higher levels of serum ECP (median 17.2 vs. 12.6 mu g/L, p = 0.07), as compared to their HRV- counterparts.

    Conclusions: Absence of symptoms of respiratory tract infection notwithstanding, HRV seems to be more prevalent in the airways of adolescents and young adults with asthma and a high degree of aeroallergen IgE sensitisation than in controls. The presence of HRV seems also to be related to systemic eosinophilic inflammation despite ongoing treatment with inhaled corticosteroids.

  • 252266.
    Öhrman, Mikkel
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Konstruktion av drivenhet till Veritas: Konstruktionsförslag till drivenhet2016Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    During this project a mechanical design proposal has been developed for the Veritas project at Uppsala University. The Veritas resonant inelastic X-ray scattering (RIXS) spectrometer aims at becoming a world leading beamline for RIXS in the 275-1500eV range. The instrument is almost 10 meters long and will rotate 120 degrees in the horizontal plane. Usually similar instruments are rotated manually. This project has developed a design proposal that allows the instrument to be rotated to a set angle without the need to manually move the instrument.

    The project started off with a phase of information gathering. It focused mainly on available products and suitable components. The information gathered here was later used to create concepts. To focus the concept generation on the most critical funcionality the challange was divided up into four different problems. Conecpts were generated for each of these problems. By comparing the conecepts against one another the most suitable concepts was merged into a final design proposal during a phas of embodiement design. This resultet in a motorized trolley. The trolley pulls or pushes the instrument around its rotational axis by moving along a rolled stainless steel T-profile. The final design proposal meets the mechanical and finiancial requirements set at the beginning of this project.

  • 252267.
    Öhrn, A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Blomgren, J.
    Atac, A.
    Gustavsson, C.
    Klug, J.
    Mermod, P.
    Nilsson, L.
    Pomp, S.
    Österlund, M.
    Bergenwall, B.
    Elmgren, K.
    Olsson, N.
    Tippawan, U.
    Dangtip, S.
    Phansuke, P.
    Nadel-Turonski, P.
    Jonsson, O.
    Prokofiev, A. V.
    Renberg, P. U.
    Ascher, P.
    Blideanu, V.
    Le Brun, C.
    Lecolley, J. F.
    Lecolley, F. R.
    Louvel, M.
    Marie-Noury, N.
    Schweitzer, C.
    Eudes, Ph.
    Haddad, F.
    Lebrun, C.
    Ledoux, X.
    Blann, M.
    Chiba, S.
    Duarte, H.
    Kalbach, C.
    Koning, A. J.
    Watanabe, Y.
    Inelastic neutron scattering cross sections at 96 MeV for ironManuscript (Other (popular science, discussion, etc.))
  • 252268.
    Öhrn, A
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Blomgren, J
    Department of Neutron Research. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Park, H
    Khurana, S
    Nolte, R
    Schmidt, D
    Wilhelmsen, K
    A monitor for neutron flux measurements up to 20 MeV2007In: Tenth Symposium on Neutron Dosimetry,Uppsala, Sweden, June 12-16, 2006 (accepted)., 2007Conference paper (Refereed)
  • 252269.
    Öhrn, A
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Blomgren, J
    Department of Neutron Research. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Park, H
    Khurana, S
    Nolte, R
    Schmidt, D
    Wilhelmsen, K
    A monitor for neutron flux measurements up to 20 MeV2006In: International workshop on Fast Neutron Detectors and Applications,Cape Town, South Africa, April 3-6, 2006, p. 048-Conference paper (Refereed)
  • 252270.
    Öhrn, A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research.
    Blomgren, J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research.
    Park, H.
    Khurana, S.
    Nolte, R.
    Schmidt, D.
    Wilhelmsen, K.
    Calibration procedure for a neutron monitor at energies below 20 MeV2008In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, E-ISSN 1872-9576, Vol. 592, no 3, p. 405-413Article in journal (Refereed)
    Abstract [en]

    A liquid scintillation detector aimed for neutron energy and fluence measurements in the energy region below 20 MeV has been calibrated using monoenergetic and white spectrum neutron fields. Careful measurements of the proton light output function and the response matrix have been performed allowing for the application of unfolding techniques using existing codes. The response matrix is used to characterize monoenergetic neutron fields produced by the T(d,n) reaction at low deuteron energies.

  • 252271. Öhrn, A.
    et al.
    Gustavsson, Cecilia
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Blann, M.
    Blideanu, V.
    Blomgren, Jan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Chiba, S.
    Duarte, H.
    Haddad, F.
    Kalbach, C.
    Klug, J.
    Koning, A.
    Le Brun, C.
    Lebrun, C.
    Lecolley, F. R.
    Ledoux, X.
    Marie-Noury, N.
    Mermod, P.
    Nilsson, L.
    Österlund, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Pomp, Stephan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Prokofiev, Alexander V.
    Uppsala University, The Svedberg Laboratory.
    Tippawan, U.
    Watanabe, Y.
    Measurements of Inelastic Neutron Scattering at 96 MeV from Carbon, Iron, Yttrium and Lead2011In: Journal of the Korean Physical Society, ISSN 0374-4884, E-ISSN 1976-8524, Vol. 59, no 2, p. 1817-1820Article in journal (Refereed)
    Abstract [en]

    Inelastic neutron scattering for (12)C, (58)Fe, (89)Y and (208)Pb have been measured at 96 MeV at the The Svedberg Laboratory in Uppsala and double-differential cross sections are reported. Data cover an excitation energy range of 0-45 MeV and the angular intervals are 28 - 58 degrees for (12)C, 26 - 65 degrees for (58)Fe and 26 - 52 degrees for (89)Y and (208)Pb. In this experiment, neutron detection is based on conversion to protons in an active scintillator converter. An analysis technique in which the neutron spectra have been obtained through a folding procedure using the response of the detector system has been used. The results are compared to and are in reasonable agreement with several model predictions and with inelastic neutron scattering data at 65 MeV from University of California, Davis, USA.

  • 252272.
    Öhrn, A
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Klug, J
    Blomgren, J
    Department of Neutron Research. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Johansson, C
    Mermot, P
    Nilsson, L
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Pomp, S
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Österlund, M
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Prokofiev, A
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Tutin, G
    Tippawan, U
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Elastic neutron scattering at 96 MeV2007In: International Conference on Nuclear Data for Science and Technology,Nice, France, April 22-27, 2007 (accepted), 2007Conference paper (Refereed)
  • 252273. Öhrn, Anders
    et al.
    Aquilante, Francesco
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Quantum Chemistry.
    p-Benzoquinone in aqueous solution: stark shifts in spectra, asymmetry in solvent structure2007In: Physical Chemistry, Chemical Physics - PCCP, ISSN 1463-9076, E-ISSN 1463-9084, Vol. 9, p. 470-480Article in journal (Refereed)
    Abstract [en]

    Results from a simulation of p-benzoquinone (PBQ) in water is presented. An explicit solvent representation is used together with a multiconfigurational ab initio quantum chemical method. The electronic n -> pi* transitions are studied in aqueous solution and the two such transitions are both blue-shifted but to different degree. Both non-equilibrium and many-body effects are found to have decisive influence on the solvation: despite stronger hydrogen bonding between solute and solvent in an excited state than in the ground state, there is a blue-shift, and the solvent structure around the non-polar PBQ is asymmetric, which is argued to come from special many-body effects. The unusual result of strengthened hydrogen bonds in the excited state that follows from an excitation of a non-bonding electron on a proton acceptor, is explained by the near-linear Stark shift that is present in the transition.

  • 252274.
    Öhrn, Angelica
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Neutron Scattering at 96 MeV2008Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Data on elastic scattering of 96 MeV neutrons from 56Fe, 89Y and 208Pb in the angular interval 10-70° are presented. The previously published data on 208Pb have been extended, as a new method has been developed to obtain additional information at the most forward angles. The results are compared with phenomenological and microscopic optical potentials. The theory predictions are in general in good agreement with the experimental data.

    A study of the deviation of the zero-degree cross section from Wick's limit has been performed. The data on 208Pb are in agreement with Wick's limit, while those on lighter nuclei overshoot the limit significantly.

    A novel analysis method has been developed to obtain the inelastic neutron emission cross sections from the existing 56Fe data. The method is based on folding a trial spectrum with the response of the detector setup. The data cover the angular interval 26-65° and an excitation energy range of 0-45 MeV, ranges hitherto not studied. The results are compared with nuclear model predictions and found to be in good agreement with the experimental data.

    List of papers
    1. Elastic neutron scattering at 96 MeV from 12C and 208Pb
    Open this publication in new window or tab >>Elastic neutron scattering at 96 MeV from 12C and 208Pb
    Show others...
    2003 (English)In: Physical Review C, Vol. 68, p. 064605-064622Article in journal (Refereed) Published
    Identifiers
    urn:nbn:se:uu:diva-96691 (URN)
    Available from: 2008-02-08 Created: 2008-02-08 Last updated: 2019-02-28
    2. 95 MeV neutron scattering on hydrogen, deuterium, carbon and oxygen
    Open this publication in new window or tab >>95 MeV neutron scattering on hydrogen, deuterium, carbon and oxygen
    Show others...
    2006 (English)In: Physical Review C. Nuclear Physics, ISSN 0556-2813, E-ISSN 1089-490X, Vol. 74, no 5, p. 054002-Article in journal (Refereed) Published
    Abstract [en]

    Three neutron-deuteron scattering experiments at 95 MeV have been performed recently at The Svedberg Laboratory in Uppsala. Subsets of the results of these experiments have been reported in two short articles, showing clear evidence for three-nucleon force effects. In this paper, we present a more detailed description of the experimental methods as well as further discussion of the results. In addition to neutron-deuteron scattering data, neutron-proton and C12(n,n) elastic scattering data have been measured for normalization purposes, and O16(n,n) data have been obtained for the first time at this energy. It was possible to extract C12(n,n') and O16(n,n') inelastic scattering cross sections to excited states below 12 MeV excitation energy. The inelastic scattering data (for both carbon and oxygen) are shown to have a significant impact on the determination of nuclear recoil kerma coefficients.

    National Category
    Physical Sciences
    Identifiers
    urn:nbn:se:uu:diva-96692 (URN)10.1103/PhysRevC.74.054002 (DOI)000242409500008 ()
    Available from: 2008-02-08 Created: 2008-02-08 Last updated: 2019-02-28
    3. Elastic scattering of 96 MeV neutrons from iron, yttrium, and lead
    Open this publication in new window or tab >>Elastic scattering of 96 MeV neutrons from iron, yttrium, and lead
    Show others...
    2008 (English)In: Physical Review C. Nuclear Physics, ISSN 0556-2813, E-ISSN 1089-490X, Vol. 77, no 2, p. 024605-Article in journal (Refereed) Published
    Abstract [en]

    Data on elastic scattering of 96 MeV neutrons from Fe-56, Y-89, and Pb-208 in the angular interval 10-70 degrees are reported. The previously published data on Pb-208 have been extended, as a new method has been developed to obtain more information from data, namely to increase the number of angular bins at the most forward angles. A study of the deviation of the zero-degree cross section from Wick's limit has been performed. It was shown that the data on Pb-208 are in agreement with Wick's limit while those on the lighter nuclei overshoot the limit significantly. The results are compared with modern optical model predictions, based on phenomenology and microscopic nuclear theory. The data on Fe-56, Y-89, and Pb-208 are in general in good agreement with the model predictions.

    National Category
    Physical Sciences
    Identifiers
    urn:nbn:se:uu:diva-96693 (URN)10.1103/PhysRevC.77.024605 (DOI)000253764600035 ()
    Available from: 2008-02-08 Created: 2008-02-08 Last updated: 2019-02-28Bibliographically approved
    4. Inelastic neutron scattering cross sections at 96 MeV for iron
    Open this publication in new window or tab >>Inelastic neutron scattering cross sections at 96 MeV for iron
    Show others...
    (English)Manuscript (Other (popular science, discussion, etc.))
    Identifiers
    urn:nbn:se:uu:diva-96694 (URN)
    Available from: 2008-02-08 Created: 2008-02-08 Last updated: 2013-02-18
  • 252275.
    Öhrn, Angelica
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Blomgren, Jan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Andersson, P.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Atac, Ayse
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Gustavsson, Cecilia
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Klug, J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Mermod, P.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Pomp, Stephan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Wolniewicz, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Österlund, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Nilsson, Leif
    Uppsala University, The Svedberg Laboratory. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Bergenwall, B.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Radiation Sciences.
    Elmgren, K.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Olsson, N.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Tippawan, Udomrat
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Dangtip, S.
    Phansuke, P.
    Nadel-Turonski, P.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Radiation Sciences.
    Jonsson, O.
    Uppsala University, The Svedberg Laboratory.
    Prokofiev, A. V.
    Uppsala University, The Svedberg Laboratory.
    Renberg, P. U.
    Uppsala University, The Svedberg Laboratory.
    Blideanu, V.
    Le Brun, C.
    Lecolley, J. F.
    Lecolley, F. R.
    Louvel, M.
    Marie-Noury, N.
    Schweitzer, C.
    Eudes, Ph.
    Haddad, F.
    Lebrun, C.
    Bauge, E.
    Delaroche, J. P.
    Girod, M.
    Ledoux, X.
    Amos, K.
    Karataglidis, S.
    Crespo, R.
    Haider, W.
    Elastic scattering of 96 MeV neutrons from iron, yttrium, and lead2008In: Physical Review C. Nuclear Physics, ISSN 0556-2813, E-ISSN 1089-490X, Vol. 77, no 2, p. 024605-Article in journal (Refereed)
    Abstract [en]

    Data on elastic scattering of 96 MeV neutrons from Fe-56, Y-89, and Pb-208 in the angular interval 10-70 degrees are reported. The previously published data on Pb-208 have been extended, as a new method has been developed to obtain more information from data, namely to increase the number of angular bins at the most forward angles. A study of the deviation of the zero-degree cross section from Wick's limit has been performed. It was shown that the data on Pb-208 are in agreement with Wick's limit while those on the lighter nuclei overshoot the limit significantly. The results are compared with modern optical model predictions, based on phenomenology and microscopic nuclear theory. The data on Fe-56, Y-89, and Pb-208 are in general in good agreement with the model predictions.

  • 252276.
    Öhrn, Angelica
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Blomgren, Jan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Neutron Research, Applied Nuclear Physics.
    Park, H.
    Khurana, S.
    Nolte, R.
    Schmidt, D.
    A monitor for neutron flux measurements up to 20 MeV2007In: Radiation Protection Dosimetry, ISSN 0144-8420, E-ISSN 1742-3406, Vol. 126, no 1-4, p. 394-397Article in journal (Refereed)
    Abstract [en]

    A liquid scintillation detector aimed for neutron energy andfluence measurements in the energy region <20 MeV has beencalibrated using monoenergetic and white spectrum neutron fields.Careful measurements of the proton light output function andthe response matrix have been performed allowing for the applicationof unfolding techniques using existing codes. The response matrixis used to characterise monoenergetic neutron fields producedby the T(d,n) at a low-energy deuteron accelerator installedat the Swedish Defense Research Agency (FOI).

  • 252277.
    Öhrn, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Visual Information and Interaction.
    General image classifier for fluorescence microscopy using transfer learning2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Modern microscopy and automation technologies enable experiments which can produce millions of images each day. The valuable information is often sparse, and requires clever methods to find useful data. In this thesis a general image classification tool for fluorescence microscopy images was developed usingfeatures extracted from a general Convolutional Neural Network (CNN) trained on natural images. The user selects interesting regions in a microscopy image and then, through an iterative process, using active learning, continually builds a training data set to train a classifier that finds similar regions in other images. The classifier uses conformal prediction to find samples that, if labeled, would most improve the learned model as well as specifying the frequency of errors the classifier commits. The result show that with the appropriate choice of significance one can reach a high confidence in true positive. The active learning approach increased the precision with a downside of finding fewer examples.

  • 252278.
    Öhrn, Håkan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Scientific Computing.
    Lindell, Adam
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Scientific Computing.
    Discretization of the Dirac delta function for application in option pricing2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This paper compares two different approximations of the Dirac deltafunction used in a Fokker-Planck equation. Both methods deal with the singularity problem in the initial condition. The Dirac delta approximation, constructed in MATLAB with a method derived by Tornberg and Engquist, was compared to an already given method Aït-Sahalia. The methods were implemented as the initial condition in the Fokker-Planck equation, e.g approximating a probability density function. In most cases Aït-Sahalia and Tornberg-Engquist were interchangeable. During specific circumstances one method was significantly more accurate than the other. Increasing the amount of time/spatial steps enhanced the differences in error while having less time/spatial steps made the difference in error converge. The Aït-Sahalia method produces slightly more accurate results in more cases.

  • 252279.
    Öhrn, Jan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Transparent and Fluid: Is a liquid loyalty the answer? Nurses and loyalty in a postmodern context2014Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • 252280.
    Öhrn, Jonas
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Sundqvist, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Tidsåtgång på akutmottagningen - patienter med bröstsmärta: En kvantitativ observationsstudie2010Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    ABSTRAKT

     

    Patienter spenderar generellt lång tid på akutmottagningen, och i samband med Akademiska sjukhusets LEAN-arbete för att effektivisera akutvården så gjordes denna tidsstudie. Syftet med studien var att undersöka hur lång tid patienter med bröstsmärta spenderar på akutmottagningen, hur lång tid det tar innan de blir triagerade och hur lång tid det tar innan de träffar en läkare. Könsskillnader och huruvida patienterna ankom i ambulans eller via reception studerades. Studien var en kvantitativ observationsstudie där 48 patienter deltog, 33 kvinnor och 15 män. Medelåldern var 56 år, och ålderspannet var 21 – 91 år. Data insamlades av studenterna själva på akutmottagningen. Patienterna som inkluderades i studien ankom på förmiddagen, måndag till fredag, under en treveckorsperiod.

     

    Patienterna spenderade i genomsnitt 207 minuter på akutmottagningen. Triagering skedde i genomsnitt efter 21 minuter, och patienterna fick träffa en läkare efter 80 minuter. Antalet kvinnor (n=33) som deltog var högre än antalet män (n=15) och männen spenderade något längre tid på akutmottagningen än kvinnorna. Männen ankom i högre utsträckning via ambulans (47 %, n=15) än kvinnorna (39 %, n=33). Män träffade en läkare i genomsnitt 34 minuter innan kvinnorna (m=57, m=91, p=0,048).

     

    Patienterna spenderar ganska lång tid på akutmottagningen. Systemet kan effektiviseras betydligt. Att triageras går relativt fort. Det tar relativt lång tid att få träffa en läkare. Det är stor skillnad i den tid det tar för kvinnor och män att få träffa en läkare. Det behövs mer studier i varför det är könsbaserade skillnader.

     

    Nyckelord: LEAN, akutmottagning, bröstsmärta, tidsstudie.

     

     

     

     

  • 252281.
    Öhrn, K
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Technology, Department of Materials Science. SIGNALS AND SYSTEMS.
    Ahlén, A
    Sternad, M
    A probabilistic approach to multivariable robust filtering and open-loop control1995In: IEEE Transactions on Automatic Control, Vol. 40, p. 405-418Article in journal (Refereed)
  • 252282.
    Öhrn, K
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Technology, Department of Materials Science. SIGNALS AND SYSTEMS.
    Ahlén, A
    Sternad, M
    A probabilistic approach to multivariable robust filtering and open-loop control1995In: IEEE TRANSACTIONS ON AUTOMATIC CONTROL, ISSN 0018-9286, Vol. 40, no 3, p. 405-418Article in journal (Refereed)
    Abstract [en]

    A new approach to robust filtering, prediction, and smoothing of discrete-time signal vectors is presented. Linear time-invariant filters are designed to be insensitive to spectral uncertainty in signal models. The goal is to obtain a simple design method

  • 252283.
    Öhrn, K
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Technology, Department of Materials Science. SIGNALS AND SYSTEMS.
    Ahlén, A
    Sternad, M
    A probabilistic approach to multivariable robust filtering, prediction and smoothing1993In: 32nd IEEE Conference on Decision and Control, San Antonio, TX, 1993, p. 1227-1232Conference paper (Other scientific)
  • 252284.
    Öhrn, K.
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Information Science.
    Crossner, C.-G.
    Börgesson, I.
    Taube, Adam
    Accuracy of dental hygienists in diagnosing dental decay1996In: Communit Dentistry and Oral Epidemiology, Vol. 24, p. 182-186Article in journal (Refereed)
  • 252285.
    Öhrn, K.E.O.
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Sjödén, P.-O
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Experiences of oral care in patietns with haematological malignancies or head and neck cancer2003In: European Journal of Cancer Care, Vol. 12, p. 274-Article in journal (Refereed)
  • 252286.
    Öhrn, Kerstin
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Oral care in cancer nursing1998In: Swedish Dental Journal, Vol. 22, p. 249-Article in journal (Other scientific)
  • 252287.
    Öhrn, Kerstin
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Oral health and experience of oral care among cancer patients during radio- or chemotherapy2001Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Oral complications and symptoms are common among patients with cancer. The aim of this thesis is to study several aspects of oral status, oral health and its relation to quality of life, and oral care among patients treated with radiotherapy or chemotherapy. Descriptive, comparative and correlational designs were used.

    A series of consecutive patients admitted to a university hospital or a regional hospital to receive radiotherapy for head and neck cancer or chemotherapy for haematological malignancies, were studied prospectively with regard to oral symptoms and their relation to health-related quality of life using interviews and questionnaires, examination of the oral cavity and saliva tests. All nurses and enrolled nurses who worked with these patients or with patients with lung cancer were interviewed about their education and knowledge in oral care and performed oral care. The medical and nursing records on patients with these cancer diseases at the two hospitals were reviewed.

    The results indicate that patients receiving radiotherapy experienced increasing oral symptoms, which remained to a large extent one month after treatment. Patients receiving chemotherapy did not experience oral symptoms to the same extent. The oral symptoms were significantly related to patients' health-related quality of life, particularly among those receiving radiotherapy. Data also indicate that there is a lack of adequate education and continuing education in oral care among nursing staff. All patients were not examined orally before or during treatment, nor did they receive sufficient information or instruction related to oral hygiene. Patient compliance with oral hygiene procedures was acceptable, although some patients reported difficulties. Oral status and oral care were insufficiently documented, particularly in nursing records. The attitudes to oral examination and discussion on oral hygiene differed between nursing staff and patients. Nursing staff objected to examining the oral cavity referring to patient integrity. This was not considered as a hindrance among patients. In conclusion, oral health is related to health-related quality of life, which motivates a multi-disciplinary approach to oral care.

  • 252288. Öhrn, Magnus
    ”Har du börjat ruttna i kolan?” – om värderingen av pojkdiskurs i svensk barn- och ungdomslitteratur2008In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 129, p. 305-314Article in journal (Refereed)
  • 252289.
    Öhrn, Nicole
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Johnston, Nikolina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Från idé till handling: En fallstudie om de största barriärerna till en lyckad implementering av centrala mångfaldsinitiativ i en stor organisation2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Allt fler organisationer strävar idag efter att skapa mångfald på arbetsplatsen. Tidigare forskning indikerar positiva effekter för de organisationer som har lyckats med implementeringen av mångfaldsinitiativ, såsom förbättrat finansiellt resultat och ökade marknadsandelar till följd av en bredare kundbas. Implementeringen av mångfaldsinitiativ är dock förknippad med en hel del svårigheter. Tidigare studier har bland annat visat att organisationens storlek, begränsad tillgång till resurser och en oförmåga att acceptera mångfaldsinitiativ kan utgöra barriärer till en lyckad implementering. Syftet med studien är således att utforska de största barriärerna till att implementera centrala mångfaldsinitiativ i en stor organisation. Resultatet av studien ger stöd för tidigare forskning samt belyser nya barriärer som kan utgöra hinder vid implementeringen av mångfaldsinitiativ. De barriärer som upplevdes som störst var en oförmåga att förstå mångfald, olika typer av rädsla hos organisationens medlemmar och brist på engagemang hos högsta ledningen. Studien ämnar även ge förslag på hur organisationer kan komma över de största barriärerna. Resultatet av studien visar att både inspirerande och styrande lösningar kan fungera som potentiella lösningar men att det troligen krävs en balans mellan dessa.

  • 252290.
    Öhrn, Nicole
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Zamore, Judith
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Communicating Goodness - loud as a lion or silent as a mouse?: A study exploring how companies find the balance in their CSR-communication2016Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Problem: Corporate social responsibility is said to result in strategic and reputational benefits, however, broadcasting it publicly has been proven to be a delicate matter. While stakeholders expect companies to engage in CSR, they do not appreciate if companies communicate their CSR-activities too loudly. Prior research instead suggests that communicating too extensively could cause skepticism from stakeholders.

    Purpose: This thesis is set to investigate how companies view and handle the challenge of communicating their good deeds, in the specific context of cross-sector collaborations, and how companies balance the need to increase awareness of their social engagements with the risk of inducing skepticism.

    Method: Primary data has been collected from semi-structured interviews within six case companies from different industries.

    Conclusion: Our results show that skepticism per se was not perceived as a problem – one reason could be that most companies chose to avoid communicating extensively. While all companies argued for the importance of doing rather than talking, controversial companies in particular expressed an aversion towards bragging about their collaborations. A difference between controversial and neutral industries could be seen in the way they valued communication. Having the right level of communication, demonstrating authenticity by linking cross-sector collaborations to company characteristics, together with the choice of partners and communicating “through” NPOs were seen as important aspects that could help companies to find the balance. 

  • 252291.
    Öhrn, Per-Gösta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
    Postoperative gastrointestinal propulsion: the role of sympatho-adrenal activity studied in the rat 1976Doctoral thesis, comprehensive summary (Other academic)
  • 252292.
    Öhrn, Yngve
    Uppsala University, Disciplinary Domain of Science and Technology.
    Quantum mechanical studies of electronic spectra of atomic and pi-electron systems1966Doctoral thesis, comprehensive summary (Other academic)
  • 252293.
    Öhrn Yngve, Sabin John R., Brändas Erkki
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Physics. QUANTUM CHEMISTRY.
    Per-Olov Löwdin 1916-20002001In: International Journal of Quantum Chemistry, Vol. 81, no 1, p. 1-2Other (Other scientific)
  • 252294.
    Öhrnell, Gunnar
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Sun, Yunchen
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Attitude, Activity and Destination Brand Identity among Swedish Entrepreneurs in Heritage Tourism: a case study of the UNESCO site of Decorated Farmhouses in Hälsingland2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Being one of the fastest growing industries, tourism has a trend to offer more innovative products and services. New opportunities and challenges have come for entrepreneurs and SMEs. Heritage tourism is one type of experience-based tourism where people can get historical or cultural experience. The potential of heritage tourism has attracted many entrepreneurs. It has been recognised activities are motivated by attitude within an entrepreneurial setting, however how the destination brand identity impacts the relationship from a supplier’s perspective is not clear. This thesis investigates the influence of destination brand on the entrepreneurs in a heritage tourism. A qualitative research design was constructed and the research strategy of a case study of the Swedish World Heritage site of Decorated Farmhouses of Hälsingland (Hälsingegårdar) was chosen. There are only seven farmhouses to represent the UNESCO site and also 34 non-listed farmhouses open to the public. After examining both groups, it could be concluded that the destination brand of a World Heritage Site will motivate the entrepreneurs to look for opportunities, which will strengthen their attitudes. However, the relationship between attitude and activity is weak due to the effect of other external factors. 

  • 252295.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    About Belonging In Changing Times: On the Art of Chun Lee Wang Gurt2001Other (Other (popular scientific, debate etc.))
  • 252296.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    After Post Modernism- On Possible and Impossible Strategies in Swedish Contemporary Art,: Efter Postmodernismen - om möjliga och omöjliga strategier i svensk samtidskonst2006In: The Moderna Exhibition 2006 feb 18 - maj 7:´When am I?: Modernautställningen 2006, 18 februari - 7 maj; När är jag?, Moderna Museet, Stockholm , 2006, p. 333-Chapter in book (Other scientific)
  • 252297.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    An Epic in Stockholm - Paul Thek & Friends1996In: Siksi: The Nordic Art Review, ISSN 0782-7423, no 1Article in journal (Other (popular scientific, debate etc.))
  • 252298.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Anders Widoff1996In: Ostsee-Biennale 1996 Bekannt(-)Machung, Kunsthalle Rostick, Rostock , 1996Chapter in book (Other (popular scientific, debate etc.))
  • 252299.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Annica Karlsson Rixon; Porträtt1998Other (Other (popular scientific, debate etc.))
  • 252300.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Annika by the Sea - A Project by Annica Karlsson Rixon2003In: n.paradoxa: International Feminist Art Journal, ISSN 1461-0343, Vol. 11, p. 38-43 ill.Article in journal (Other scientific)
5043504450455046504750485049 252251 - 252300 of 253731
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