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  • 252301.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Aspects of Gender and Transnational Politics in Swedish Art2006In: BENT: Gender and Sexuality In Contemporary Art, San Francisco State University, San Francisco , 2006, p. 22-33Chapter in book (Other scientific)
  • 252302.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Barbro Östlihn arbetade precist, med durkdrivet handlag på rekordtid och Öyvind Fahlström signerade2007In: Med världen som spelplan: Öyvind Fahlström : 3 juni - 16 september 2007 / [ed] Sophie Allgårdh, Halmstad: Mjellby konstmuseum , 2007, p. 86-101Chapter in book (Other (popular science, discussion, etc.))
  • 252303.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Barbro Östlihn; liv och konst: Barbro Östlihn; Life and Art2003Book (Other scientific)
  • 252304.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Barbro Östlihn och New York: Konstens rum och möjligheter2010Doctoral thesis, monograph (Other academic)
    Abstract [en]

    The study analyses the American neo-avantgarde as well as the narratives of Swedish post World War II art history, through a specific subject position. The Swedish painter Barbro Östlihn (1930-1995) lived in New York from 1961, where her work was exhibited and received on a new art scene. Despite the strong focus within Swedish Art History on the 1960’s and the American art scene, Östlihn seems to be marginalized in its narratives.

    Studies of selected corpora of American art criticism, and of segments in the Swedish art scene in the 1960’s are maintained. Discursive and field-related mechanisms, which help to explain what positions were available, are revealed. Transnational processes of avant-garde culture between Manhattan and Stockholm are discussed, e.g. through an analysis of the American pop art show at Moderna Museet in 1964. This becomes the backdrop for the final chapter’s discussion of the narratives in post World War II Art History in Sweden.

    In the interpretation of Östlihn’s work-process, her use of photography is understood as a strategy to connect her painterly work with urban space. The painterly and the photographic are merged, as in other artistic practices in a historical moment of crisis in painting. The studio, the site where modes of art production are constructed, is one point of departure in a spatial analysis of the art field. Another is the ongoing urban renewal on Lower Manhattan and its impact on artistic work and on how artists are positioned. Östlihn’s co-operation in the work of her husband Öyvind Fahlström, is understood as a merging of a traditional division of work between genders, and new co-operative modes of art-production.

    The study is the first academic work on Barbro Östlihn, and covers the time span 1960-1969. Feminist theory, Pierre Bourdieu’s field theory and Michel Foucault's discourse theory is used as its main framework.

  • 252305.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Bedeutung, Übertragung, Zirkulation: Über die Arbeit von Anna Brag2001In: Be Magazine, ISSN 0946-3585Article in journal (Other scientific)
  • 252306.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Birgitta Hvas: Karl Isaksson, ett liv i konst.: (Recension.)1992In: Valör, ISSN 0283-751X, Vol. 3, p. s. 54-55Article in journal (Other (popular scientific, debate etc.))
  • 252307.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Charlotte Gyllenhammar; Fall2001Other (Other (popular scientific, debate etc.))
  • 252308.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Cubism in transit: Siri Derkert and the early Parisian avant-garde2012In: Transferts, appropriations et fonctions de l'avant-garde dans l'Europe intermédiaire et du Nord / [ed] Harri Veivo, Paris: L'Harmattan , 2012, Vol. 14, p. 29-45Chapter in book (Refereed)
  • 252309.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Dam i Landskap – Siri Derkert i modernismen2001In: Siri Derkert, modernist och modetecknare, Centrum för textilforskning, CTF, Borås , 2001Chapter in book (Other scientific)
  • 252310.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Debatt: Det finns en ny offentlig konst1999In: Dagens Nyheter, Vol. 12 augustiArticle in journal (Other (popular scientific, debate etc.))
  • 252311.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Då finns den plötsligt där: Intervju med Katrine Helmerson1992In: Divan: Tidskrift för Psykoanalys och kultur, ISSN 1101-1408, no 5Article in journal (Other (popular scientific, debate etc.))
  • 252312.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Ett konstnärsarkiv2011In: Att alltid göra och tänka det olika: Siri Derkert och 1900-talet / [ed] Mats Rohdin & Annika Öhrner, Stockholm: Kungliga biblioteket , 2011, p. 9-26Chapter in book (Other academic)
  • 252313.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Ett porträtt av Siri Derkert1986In: Porträtt, porträtt: Studier i Statens porträttsamling på Gripsholm, 1986Chapter in book (Other (popular scientific, debate etc.))
  • 252314.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Gabriele Münters måleri 1915-1917, i ljuset av en receptionsproblematik.1986Other (Other scientific)
  • 252315.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Gatan blir Galleri i Beijing, om Zhang Wang och Zhang Dali2001In: Konstperspektiv, Lund, ISSN 0347-4453, no 1Article in journal (Other (popular scientific, debate etc.))
  • 252316.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Herdarna, en utställning av Matts Leiderstam1994Book (Other (popular scientific, debate etc.))
  • 252317.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Hilma af Klint1997In: Dictionary of Women Artists, Fitzroy Dearborn Publishers , 1997, p. 784-786Chapter in book (Other (popular scientific, debate etc.))
  • 252318.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Ich lebte in Prophetenstand: jetzt bin ich Weltkind geworden, Gabriele Münter in Skandinavien 1915-19201992In: Gabriele Münter 1877-1962: Retrospektive / [ed] Annegret Hoberg & Helmut Friedel, München: Prestel Verlag , 1992, p. 67-84Chapter in book (Other academic)
  • 252319.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Ich lebte in Prophetenstand-jetzt bin ich Weltkind geworden: Gabriele Münter in Skandinavien 1915-19201992In: Gabriele Münter 1877-1962, Prestel Verlag, München , 1992Chapter in book (Other (popular scientific, debate etc.))
  • 252320.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Idag har filmen ersatt måleriet: Samtal med Luc Tuymans1994In: Material: Journal of Contemporary Art, ISSN 1101-7762, Vol. 5, p. 10 ill.-Article in journal (Other (popular scientific, debate etc.))
  • 252321.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Katarina Andersson2000In: 00 tal: Tidskrift för litteratur och konst, no 4Article in journal (Other (popular scientific, debate etc.))
  • 252322.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Kunsthistorikerinnentagung i Hamburg i 18-21 juli 19911992In: Kvinnovetenskapligt Tidskrift, ISSN 1101-1408, Vol. 1, p. s. 66-67Article, book review (Other (popular scientific, debate etc.))
  • 252323.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Meret Oppenheim, inledning/introduction2004In: Meret Oppenheim: Moderna museet [4.9 - 31.10] 2004, Moderna Museet, Stockholm , 2004, p. 7-13Chapter in book (Other (popular scientific, debate etc.))
  • 252324.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Miroslaw Balka, en minnesvård1998Book (Other (popular scientific, debate etc.))
    Abstract [en]

    Om Estonia-offrens minnesvård på Djurgården i Stockholm, av den polske skulptören Miroslaw Balka.

  • 252325.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History. Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Moderna Museet in Stockholm: The Institution and the Avant-garde2011In: Nordic Avant Garde History, bind III / [ed] Tania Ørum et al., Amsterdam & New York: Rodopi , 2011Chapter in book (Other academic)
  • 252326.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Om konstruktionen av en brytpunkt i amerikansk konstkritik i tidigt 1960-tal.2005In: Rauschenbergseminariet, Moderna Museet och Konstvetenskapliga institutionen, Uppsala universitet, 2005Conference paper (Other (popular scientific, debate etc.))
  • 252327.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
     : Om Siri Derkerts illustrationer till en novell av Halldór K. Laxness1991In: Valör, ISSN ISSN 0283-751X, Vol. 1, p. s.3-13Article in journal (Other (popular scientific, debate etc.))
  • 252328.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Om sju konstverk i Huset: A. Kapoor, A.V. Janssen, Perejaume, R. Guillén-Balmes, CM von Hausswolff, S. Sze, Sommerer/Mignonneau2001In: Vision Art Exhibitions, Bo01, Utgiven av Bo01, Framtidsstaden. Europeisk mässa och utställning/ City of Tomorrow, European Housing Expo, Malmö , 2001, p. s. 107-136, färgill.Chapter in book (Other (popular scientific, debate etc.))
  • 252329.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Painting Manhattan in the Era of Pop - Barbro Östlihn2010In: Seductive Subversion: women Pop Artists 1958-1968 / [ed] Sid Sachs & Kalliopi Minioudaki, Philadelphia: University of the Arts , 2010, p. 194-199Chapter in book (Other academic)
  • 252330.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Radikalisering av konstvetenskapen i Stockholm och Lund2011In: Praktiske grunde. Tidsskrift for kultur og samfunnsvitenskab, ISSN 1902-2271, E-ISSN 1902-2271, no 4, p. 57-66Article in journal (Refereed)
  • 252331.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Recalling Pelican: On P.O. Ultvedt, Robert Rauschenberg and Two "Ballets"2007In: Konsthistorisk Tidskrift, ISSN 0023-3609, E-ISSN 1651-2294, Vol. 76, no 1-2, p. 27-39Article in journal (Refereed)
  • 252332.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Siri Derkert2011Collection (editor) (Other academic)
  • 252333.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Siri Derkert1994In: Den otroliga verkligheten: 13 kvinnliga konstnärer, 1994Chapter in book (Other (popular scientific, debate etc.))
  • 252334.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Siri Derkert och Halldor K Laxness Den goda fröken och huset1989In: Den goda fröken och huset´; Halldor K. Laxness, Siri Derkert, Alfabeta, Stockholm , 1989, p. s. 101-111Chapter in book (Other scientific)
  • 252335.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Siri Derkert och kubismen2011In: Siri Derkert / [ed] Annika Öhrner, Stockholm: Atlantis , 2011, p. 280-Chapter in book (Other academic)
  • 252336.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Siri Derkerts förnekade måleri2003In: Artes: tidsrkift för litteratur, konst och musik, ISSN ISSN 1104-8247, Vol. 1, no 1Article in journal (Other scientific)
  • 252337.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Sonsbeek 93 - vandring i Arnhem1993In: Tidskriften 90-tal om litteratur och konst, no 10Article in journal (Other (popular scientific, debate etc.))
  • 252338.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Still Life: [Om Andy Goldsworthy]1990In: Utblick Landskap, ISSN 0281-7462, no 3Article in journal (Other (popular scientific, debate etc.))
  • 252339.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
     Till Mary/To Mary [Wollstonecraft]: från/from Annika Eriksson, Anna-Karin Palm, Katy Shepherd, Vibeke Tandberg1995Book (Other (popular scientific, debate etc.))
  • 252340.
    Öhrner, Annika
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Upptäcktsresarna: Richard Long, Andy Goldsworthy1992In: Utblick Landskap, no 2Article in journal (Other (popular scientific, debate etc.))
  • 252341.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History. Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Yvonne Rainer and Robert Morris; An Evening of Talking and Dancing, 19642011In: Nordic Avant Garde History / [ed] Tania Ørum et al., Amsterdam & New York: Rodopi , 2011Chapter in book (Other academic)
  • 252342.
    Öhrner, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Öyvind Fahlström. World Making.2012In: Flash Art, ISSN 0394-1493, Vol. XLV, no 283, p. 76-78Article in journal (Other (popular science, discussion, etc.))
  • 252343.
    Öhrner, Annika
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Arts, Department of Art History.
    Hallin, Eva
    Konst, kön och kunskap - om den konstnärliga praktiken1992In: Kvinnovetenskaplig Tidskrift, ISSN 0348-8365, no 2, p. 42-53 ill.Article in journal (Refereed)
    Abstract [en]

    This article is based on interviews with five Swedish artists, Ann Edholm, Maya Eizin, Marianne Lindberg de Geer, Eva Löfdahl and Sophie Tottie. Since these artists show a consciousness of gender and of the production of meaning in the visual arts, we found it interesting to connect their experience with the production of knowledge, which is one of the concerns of feminist art historians. The interviewed were not feminists in any determined sense. They represent divrese career stages as well as diverse artistic expressions. In the interviews various topics were touched upon - such as what it means to be inscribed within the "feminine"; their relationship to the concept and identity of the artists, whether visual representations may carry an essential femininity, and being a woman artists in today's art world. None of them was willing to identify anything essentially feminine in art. Instead, aspects of gender differentiation were discussed regard to positionings and strategies in the context of education, recieveing grants, sharing studios, participating in all-women shows, stating opinions in conferences and debates, and so on. A common view was that art critics and other interpreters often have a narrow outlook and lack an independent attitude in relation to the dominant ways of description and valuation of art. We take this as an urgent appeal request from artists to the feminist art historian who do research within contemporary art today.

  • 252344.
    Öhrner, Annika
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Lalander, Folke
    Gabriele Münters svenska vänner: april-maj 19931993Book (Other (popular science, discussion, etc.))
  • 252345.
    Öhrngren, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Tertiary Alcohol- or β-Hydroxy γ-Lactam-Based HIV-1 Protease Inhibitors: Microwave Applications in Batch and Continuous Flow Organic Synthesis2011Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Since the outbreak of the HIV/AIDS pandemic in the 1980s, the disease has cost the lives of over 30 million people, and a further 33 million are currently living with the HIV infection. With the appropriate treatment, HIV/AIDS can today be regarded as a chronic but manageable disease. However, treatment is not available globally and UNAIDS still estimates that there are currently 5000 AIDS-related deaths worldwide per day.

    HIV protease inhibitors (PIs) constitute one of the fundaments of HIV treatment, and are commonly used in so-called highly active antiretroviral therapy (HAART), together with reverse transcriptase inhibitors. Although there are ten PIs on the market, there is still a need for novel structures. The rapid development of resistant strains, due to the high frequency of mutations, together with the commonly observed adverse effects of the drugs available, illustrate the need to develop new potent structures.

    Two novel scaffolds were investigated in this work. A tertiary alcohol-containing scaffold comprising a three-carbon tether, and a β-hydroxy γ-lactam-based scaffold were designed, synthesized and evaluated using enzyme- and cell-based assays. X-ray analyses of inhibitors from each class provided information on inhibitor–protease interactions. The inhibitors containing the tertiary alcohol provided at best an enzymatic inhibition (Ki) of 2.3 nM, and an inhibition in the cell-based assay (EC50) of 0.17 µM. The γ-lactam-based inhibitors exhibited better inhibition than the first series; the best values being Ki = 0.7 nM and EC50 = 0.04 µM.

    The second part of these studies involved the evaluation of a novel non-resonance continuous-flow microwave instrument. The instrument was validated regarding heating capacity, temperature stability and temperature homogeneity. A number of model reactions were performed with low- and high-microwave-absorbing solvents. It was found that the microwave heating source allowed rapid temperature adjustment, together with easily regulated, flow-dependent reaction times, providing an efficient tool for reaction optimisation.

    List of papers
    1. Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic
    Open this publication in new window or tab >>Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic
    Show others...
    2008 (English)In: Journal of Medicinal Chemistry, ISSN 0022-2623, E-ISSN 1520-4804, Vol. 51, no 4, p. 1053-1057Article in journal (Refereed) Published
    Abstract [en]

    A new generation of HIV-1 protease inhibitors encompassing a tertiary-alcohol-based transition-state mimic has been developed. By elongation of the core structure of recently reported inhibitors with two carbon atoms and by varying the P1' group of the compounds, efficient inhibitors were obtained with Ki down to 2.3 nM and EC50 down to 0.17 microM. Two inhibitor-enzyme X-ray structures are reported.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-102908 (URN)10.1021/jm070680h (DOI)000253353800037 ()18215014 (PubMedID)
    Available from: 2009-05-12 Created: 2009-05-12 Last updated: 2017-12-13Bibliographically approved
    2. Hiv-1 Protease Inhibitors with a Tertiary Alcohol Containing a Transition-State Mimic and Various P2/P1´ Substituents
    Open this publication in new window or tab >>Hiv-1 Protease Inhibitors with a Tertiary Alcohol Containing a Transition-State Mimic and Various P2/P1´ Substituents
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    2011 (English)In: MedChemComm, ISSN 2040-2503, E-ISSN 2040-2511, Vol. 2, no 8, p. 701-709Article in journal (Refereed) Published
    Abstract [en]

    Two series, including in total 18 novel HIV-1 protease inhibitors, comprising a tertiary alcohol as thetransition-state mimic have been synthesised and evaluated. Replacement of the previously used, butmetabolically unstable, indanol amide group with amino acid derived aliphatic P2–P3 moietiesprovided potent inhibitors with low Ki- and EC50-values (2.7 nM and 2.0 mM, respectively). The P10subunit was varied using 10 different aromatic and heteroaromatic substituents furnishing thecorresponding inhibitors with retained activity. Permeability and stability studies showed examples inthe same range as Atazanavir. X-Ray crystallographic analysis of two selected inhibitor enzyme cocomplexes(9a and 9d) supplied detailed structural information. The binding modes were compared tothose of Atazanavir and a previously reported indanol amide containing inhibitor (14). The novelinhibitors with an elongated P1' side chain enabled a previously unexploited edge-on interaction withPhe53/153. Exchange of the previously used indanol amide P2 moiety, with a tert-leucine derived P2–P3side chain, furnished small main chain displacements in the S2–S3 pocket. The methyl amide in the P3 position caused a 2 Å shift of the Arg8/108 in comparison to 14, indicating the flexibility of the proteaseactive site.

    Keywords
    HIV, protease, inhibitor
    National Category
    Medicinal Chemistry
    Research subject
    Medicinal Chemistry
    Identifiers
    urn:nbn:se:uu:diva-135157 (URN)10.1039/c1md00077b (DOI)000295068100003 ()
    Available from: 2010-12-06 Created: 2010-12-06 Last updated: 2018-01-12Bibliographically approved
    3. Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors
    Open this publication in new window or tab >>Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors
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    2012 (English)In: Journal of Medicinal Chemistry, ISSN 0022-2623, E-ISSN 1520-4804, Vol. 55, no 6, p. 2724-2736Article in journal (Refereed) Published
    Abstract [en]

    In an effort to identify a new class of druglike HIV-1 protease inhibitors, four different stereopure beta-hydroxy gamma-lactam-containing inhibitors have been synthesized, biologically evaluated, and cocrystallized. The impact of the tether length of the central spacer (two or three carbons) was also investigated. A compound with a shorter tether and (3R,4S) absolute configuration exhibited high activity with a K-i of 2.1 nM and an EC50 of 0.64 mu M. Further optimization by decoration of the P1' side chain furnished an even more potent HIV-1 protease inhibitor (K-i = 0.8 nM, EC50 = 0.04 mu M). According to X-ray analysis, the new class of inhibitors did not fully succeed in forming two symmetric hydrogen bonds to the catalytic aspartates. The crystal structures of the complexes further explain the difference in potency between the shorter inhibitors (two-carbon spacer) and the longer inhibitors (three-carbon spacer).

    Keywords
    HIV, AIDS, protease inhibitor, aspartic protease, lactam, tertiary alcohol, X-ray
    National Category
    Medicinal Chemistry
    Research subject
    Medicinal Chemistry
    Identifiers
    urn:nbn:se:uu:diva-160186 (URN)10.1021/jm201620t (DOI)000301767000017 ()
    Available from: 2011-10-17 Created: 2011-10-17 Last updated: 2018-01-12Bibliographically approved
    4. Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications
    Open this publication in new window or tab >>Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications
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    2012 (English)In: Organic Process Research & Development, ISSN 1083-6160, E-ISSN 1520-586X, Vol. 16, no 5, p. 1053-1063Article in journal (Refereed) Published
    Abstract [en]

    The concept of a nonresonant microwave applicator for continuous-flow organic chemistry is introduced and evaluated. The frequency of the incident microwave radiation can be adjusted between 2.4 and 2.5 GHz to optimize the energy absorbance. The temperature of the reaction is monitored by five IR sensors, and their signals can be used to automatically adjust the power output from the microwave generator. The heating of several different solvents up to 20 degrees C above the standard boiling point has been explored. Several different organic reactions have been successfully carried out using a 200 mm X (sic) 3 mm tubular borosilicate reactor and a flow between 47 and 2120 mu L/min. The microwave heating pattern was visualized with an IR camera. The transformations include palladium-catalyzed coupling reactions (oxidative Heck and Suzuki reactions), heterocyclic chemistry (oxathiazolone and Fischer indole synthesis), rearrangement (Claisen), and a Diels-Alder cycloaddition reaction. A scale-out to 57 mmol/h was performed with the Fischer indole reaction.

    Keywords
    non-resonant, microwave, Continuous-Flow, MAOS, CF-MAOS
    National Category
    Medicinal Chemistry Organic Chemistry
    Research subject
    Medicinal Chemistry
    Identifiers
    urn:nbn:se:uu:diva-160187 (URN)10.1021/op300003b (DOI)000304129100036 ()
    Available from: 2011-10-17 Created: 2011-10-17 Last updated: 2018-01-12Bibliographically approved
  • 252346.
    Öhrngren, Per
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Fardost, Ashkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Russo, Francesco
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Fagrell, Magnus
    WaveCraft AB.
    Schanche, Jon-Sverre
    WaveCraft AB.
    Larhed, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications2012In: Organic Process Research & Development, ISSN 1083-6160, E-ISSN 1520-586X, Vol. 16, no 5, p. 1053-1063Article in journal (Refereed)
    Abstract [en]

    The concept of a nonresonant microwave applicator for continuous-flow organic chemistry is introduced and evaluated. The frequency of the incident microwave radiation can be adjusted between 2.4 and 2.5 GHz to optimize the energy absorbance. The temperature of the reaction is monitored by five IR sensors, and their signals can be used to automatically adjust the power output from the microwave generator. The heating of several different solvents up to 20 degrees C above the standard boiling point has been explored. Several different organic reactions have been successfully carried out using a 200 mm X (sic) 3 mm tubular borosilicate reactor and a flow between 47 and 2120 mu L/min. The microwave heating pattern was visualized with an IR camera. The transformations include palladium-catalyzed coupling reactions (oxidative Heck and Suzuki reactions), heterocyclic chemistry (oxathiazolone and Fischer indole synthesis), rearrangement (Claisen), and a Diels-Alder cycloaddition reaction. A scale-out to 57 mmol/h was performed with the Fischer indole reaction.

  • 252347.
    Öhrngren, Per
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Wu, Xiongyu
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Persson, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology.
    Ekegren, Jenny
    Wallberg, Hans
    Vrang, Lotta
    Rosenquist, Åsa
    Samuelsson, Bertil
    Unge, Torsten
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology.
    Larhed, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Hiv-1 Protease Inhibitors with a Tertiary Alcohol Containing a Transition-State Mimic and Various P2/P1´ Substituents2011In: MedChemComm, ISSN 2040-2503, E-ISSN 2040-2511, Vol. 2, no 8, p. 701-709Article in journal (Refereed)
    Abstract [en]

    Two series, including in total 18 novel HIV-1 protease inhibitors, comprising a tertiary alcohol as thetransition-state mimic have been synthesised and evaluated. Replacement of the previously used, butmetabolically unstable, indanol amide group with amino acid derived aliphatic P2–P3 moietiesprovided potent inhibitors with low Ki- and EC50-values (2.7 nM and 2.0 mM, respectively). The P10subunit was varied using 10 different aromatic and heteroaromatic substituents furnishing thecorresponding inhibitors with retained activity. Permeability and stability studies showed examples inthe same range as Atazanavir. X-Ray crystallographic analysis of two selected inhibitor enzyme cocomplexes(9a and 9d) supplied detailed structural information. The binding modes were compared tothose of Atazanavir and a previously reported indanol amide containing inhibitor (14). The novelinhibitors with an elongated P1' side chain enabled a previously unexploited edge-on interaction withPhe53/153. Exchange of the previously used indanol amide P2 moiety, with a tert-leucine derived P2–P3side chain, furnished small main chain displacements in the S2–S3 pocket. The methyl amide in the P3 position caused a 2 Å shift of the Arg8/108 in comparison to 14, indicating the flexibility of the proteaseactive site.

  • 252348.
    Öhrström, Britt-Marie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Gudinna, kvinna eller prästinna: vad visar de kvinnliga hällristningarna i Bohuslän2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Tanum, is situated in the north part of Bohuslän in Sweden and is the most famouse area of Rock Art of the world. It´s now a World Heritige since 1994. More than 100 000 images are carved on the rocks near by the sea. Archaeologists believe that carved feet and cupmarks can date from mesoliticom and neoliticum. During bronze age the sealevel was 15-20 meters higher. Carvings of humans can date from the beginning of bronze age around 1800, period I, but during late bronze age 1000-300 bc, period III-V, motives of humans became more common. Of all the 4154 carvings of human figures, only a few of them, aboute 45 figures, can be identifide as woman.  This study will try to answere why there are so few carvings of woman, what the carvings of female figures shows on the rocks and in what context are the they carved? Is the female figures an image of a godess, a woman or a priestess? Can the carvings tell us something aboute the womans life during the the bronze age?

    Key words: axes, menstruation, birthing, boats, Bohuslän, bronze age, cairns, carvings, fertilitycult, rock art, sealevel, weddings, godess, women, priestess, neoliticum, mesoliticum.                             

    Nyckelord: yxor, förlossning, menstruation, båtar, Bohuslän, bronsålder, rösen, ristningar, fruktbarhetskult, stenkonst, havsnivån, bröllop, gudinna, kvinna, prästinna, neolitikum, mesolitikum.

  • 252349.
    Öhrström, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    Kritiken om Fairtrade - En fallstudie av två rapporter.2012Student paper second term, 5 credits / 7,5 HE creditsStudent thesis
  • 252350.
    Öhrvall, Margareta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Preoperativ utredning och kontroller vid fetmakirurgi2009In: Fetma - del 1: medicinsk behandling och kognitiv beteendeterapi / [ed] Klara Edlund och Björn Zethelius, Lund: Studentlitteratur , 2009, 1, p. 215-223Chapter in book (Other academic)
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