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  • 451.
    Wandell, Per
    et al.
    Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.;Stockholm Cty Council, Acad Primary Healthcare Ctr, Huddinge, Sweden..
    Carlsson, Axel C.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden..
    Holzmann, Martin J.
    Karolinska Univ Hosp, Dept Emergency Med, Stockholm, Sweden.;Karolinska Inst, Dept Internal Med, Stockholm, Sweden..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden..
    Johansson, Sven-Erik
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Sundquist, Jan
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Sundquist, Kristina
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Warfarin treatment and risk of myocardial infarction - A cohort study of patients with atrial fibrillation treated in primary health care2016In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 221, p. 789-793Article in journal (Refereed)
    Abstract [en]

    Objective: To study the risk of myocardial infarction (MI) in patients with atrial fibrillation (AF) treated in primary health care with warfarin or acetylsalicylic acid (ASA, aspirin). Methods: The study population included subjects (n = 12,283) 45 years or older diagnosed with AF who were treated in 75 primary care centres in Sweden between 2001 and 2007. MI was defined as a hospital stay for MI during 2001 through 2010 registered in the Swedish Patient Register. Associations between warfarin or ASA treatment and incident MI were explored using Cox regression analysis, by estimating hazard ratios (HRs) and 95% confidence intervals (95% CIs). Adjustment was made for age, socio-economic factors and cardio-vascular co-morbidity. Results: Persistent treatment ("per protocol" treatment) with warfarin alone was present among 32.4% of women and 37.4% of men, and with ASA alone among 30.0% of women and 28.1% of men. The fully adjusted HRs for MI, compared to those with no antithrombotic treatment, with warfarin treatment for women were 0.26 (95% CI 0.16-0.41) and for men 0.28 (95% CI 0.20-0.39); and the corresponding HRs for those treated with ASA were for women 0.57 (95% CI 0.37-0.87), and for men 0.44 95% CI (0.31-0.63). The fully adjusted HR for MI when comparing patients with warfarin treatment to those with ASA treatment was for women 0.46 (95% CI 0.27-0.80), and for men 0.58 (95% CI 0.38-0.89). Conclusions: Warfarin seems to prevent MI among AF patients in a primary healthcare setting, which emphasizes the importance of persistent anticoagulant treatment in those patients.

  • 452.
    Wandell, Per
    et al.
    Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
    Carlsson, Axel C
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
    Holzmann, Martin J.
    Karolinska Univ Hosp, Funct Area Emergency Med, Stockholm, Sweden;Karolinska Inst, Dept Internal Med, Stockholm, Sweden.
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden; Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden.
    Sundquist, Jan
    Lund Univ, Ctr Primacy Hlth Care Res, Malmo, Sweden;Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Family Med & Community Hlth, New York, NY 10029 USA.
    Sundquist, Kristina
    Lund Univ, Ctr Primacy Hlth Care Res, Malmo, Sweden;Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Family Med & Community Hlth, New York, NY 10029 USA.
    The association between relevant co-morbidities and prevalent as well as incident heart failure in patients with atrial fibrillation2018In: Journal of Cardiology, ISSN 0914-5087, E-ISSN 1876-4738, Vol. 72, no 1-2, p. 26-32Article in journal (Refereed)
    Abstract [en]

    Background: Congestive heart failure (CHF) is a serious complication in patients with atrial fibrillation (AF). Objective: To study associations between relevant co-morbidities and CHF in patients with AF. Methods: Study population included all adults (n = 12,283) >= 45 years diagnosed with AF at 75 primary care centers in Sweden 2001-2007. Logistic regression was used to calculate odds ratios with 95% confidence intervals (Cls) for the associations between co-morbidities, and prevalent CHF. In a subsample (n = 9424), (excluding patients with earlier CHF), Cox regression was used to estimate hazard ratios with 95% as for the association between co-morbidities, and a first hospital diagnosis of CHF, after adjustment for age and socio-economic factors. Results: During 5.4 years' follow-up (standard deviation 2.5), 2259 patients (24.0%; 1135 men, 21.8%, and 1124 women, 26.7%) were diagnosed with CHF. Patients with hypertension were less likely to have CHF, while a diagnosis of coronary heart disease, valvular heart disease, diabetes, or chronic obstructive pulmonary disease (COPD), was consistently associated with CHF among men and women. CHF was more common among women with depression. The relative fully adjusted risk of incident CHF was increased for the following diseases in men with AF: valvular heart disease, cardiomyopathy, and diabetes; and for the following diseases in women: valvular heart disease, diabetes, obesity, and COPD. The corresponding risk was decreased among women for hypertension. Conclusions: In this clinical setting we found hypertension to be associated with a decreased risk of CHF among women; valvular heart disease and diabetes to be associated with an increased risk of CHF in both sexes; and cardiomyopathy to be associated with an increased risk of CHF among men. (C) 2018 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

  • 453.
    Wandell, Per
    et al.
    Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Alfred Nobels Alle 12, S-14183 Huddinge, Sweden..
    Carlsson, Axel C.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Alfred Nobels Alle 12, S-14183 Huddinge, Sweden..
    Holzmann, Martin
    Karolinska Univ Hosp, Dept Emergency Med, Stockholm, Sweden.;Karolinska Inst, Dept Internal Med, Stockholm, Sweden..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden..
    Johansson, Sven-Erik
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Sundquist, Jan
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Sundquist, Kristina
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Association between antithrombotic treatment and hemorrhagic stroke in patients with atrial fibrillation-a cohort study in primary care2017In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 73, no 2, p. 215-221Article in journal (Refereed)
    Abstract [en]

    The objective of this study was to study the association between antithrombotic treatment and risk of hemorrhagic stroke (HS) in patients with atrial fibrillation (AF) treated in primary health care. Study population included all adults (n = 12,215) 45 years and older diagnosed with AF at 75 primary care centers in Sweden 2001-2007. Outcome was defined as a first hospital episode with a discharge episode of HS after the AF diagnosis. Association between HS and persistent treatment with antithrombotic agents (warfarin, acetylsalicylic acid (ASA), clopidogrel) was explored using Cox regression analysis, with hazard ratios (HRs) and 95 % CIs. Adjustment was made for age, socioeconomic status, and co-morbid cardiovascular conditions. During a mean of 5.8 years (SD 2.4) of follow-up, 162 patients (1.3 %; 67 women and 95 men) with HS were recorded. The adjusted risk associated with persistent warfarin treatment compared to no antithrombotic treatment consistently showed no increased HS risk, HR for women 0.53 (95 % CI 0.23-1.27) and for men 0.55 (95 % CI 0.29-1.04); corresponding HRs for ASA were, for women, 0.45 (95 % CI 0.14-1.44) and, for men, 0.56 (95 % CI 0.24-1.29). In this clinical setting, we found no evidence pointing to an increased risk of HS with antithrombotic treatment.

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  • 454.
    Wandell, Per
    et al.
    Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden..
    Carlsson, Axel C
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Huddinge, Sweden.
    Li, Xinjun
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Gasevic, Danijela
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Coll Med & Vet Med, Edinburgh, Midlothian, Scotland..
    Arnlov, Johan
    Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden.;Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden..
    Holzmann, Martin J.
    Karolinska Univ Hosp, Funct Area Emergency Med, Stockholm, Sweden.;Karolinska Inst, Dept Internal Med Solna, Stockholm, Sweden..
    Sundquist, Jan
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden.;Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA..
    Sundquist, Kristina
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden.;Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA..
    Atrial fibrillation in immigrant groups: a cohort study of all adults 45 years of age and older in Sweden2017In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 32, no 9, p. 785-796Article in journal (Refereed)
    Abstract [en]

    To study the association between country of birth and incident atrial fibrillation (AF) in several immigrant groups in Sweden. The study population included all adults (n = 3,226,752) aged 45 years and older in Sweden. AF was defined as having at least one registered diagnosis of AF in the National Patient Register. The incidence of AF in different immigrant groups, using Swedish-born as referents, was assessed by Cox regression, expressed in hazard ratios (HRs) and 95% confidence intervals (CI). All models were stratified by sex and adjusted for age, geographical residence in Sweden, educational level, marital status, and neighbourhood socioeconomic status. Compared to their Swedish-born counterparts, higher incidence of AF [HR (95% CI)] was observed among men from Bosnia 1.74 (1.56-1.94) and Latvia 1.29 (1.09-1.54), and among women from Iraq 1.96 (1.67-2.31), Bosnia 1.88 (1.61-1.94), Finland 1.14 (1.11-1.17), Estonia 1.14 (1.05-1.24) and Germany 1.08 (1.03-1.14). Lower incidence of AF was noted among men (HRs > 0.60) from Iceland, Southern Europe (especially Greece, Italy and Spain), Latin America (especially Chile), Africa, Asia (including Iraq, Turkey, Lebanon and Iran), and among women from Nordic countries (except Finland), Southern Europe, Western Europe (except Germany), Africa, North America, Latin America, Iran, Lebanon and other Asian countries (except Turkey and Iraq). In conclusion, we observed substantial differences in incidence of AF between immigrant groups and the Swedish-born population. A greater awareness of the increased risk of AF development in some immigrant groups may enable for a timely diagnosis, treatment and prevention of its debilitating complications, such as stroke.

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  • 455.
    Wandell, Per
    et al.
    Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Alfred Nobels Alle 23, SE-14183 Huddinge, Sweden..
    Carlsson, Axel C
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Alfred Nobels Alle 23, SE-14183 Huddinge, Sweden..
    Li, Xinjun
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Gasevic, Danijela
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Coll Med & Vet Med, Edinburgh, Midlothian, Scotland..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Holzmann, Martin J.
    Karolinska Univ Hosp, Dept Emergency Med, Huddinge, Sweden.;Karolinska Inst, Dept Internal Med Solna, Stockholm, Sweden..
    Sundquist, Jan
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Sundquist, Kristina
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Gout in immigrant groups: a cohort study in Sweden2017In: Clinical Rheumatology, ISSN 0770-3198, E-ISSN 1434-9949, Vol. 36, no 5, p. 1091-1102Article in journal (Refereed)
    Abstract [en]

    Our aim was to study the association between country of birth and incidence of gout in different immigrant groups in Sweden. The study population included the whole population of Sweden. Gout was defined as having at least one registered diagnosis in the National Patient Register. The association between incidence of gout and country of birth was assessed by Cox regression, with hazard ratios (HRs) and 95% confidence intervals (95% CI), using Swedish-born individuals as referents. All models were conducted in both men and women, and the full model was adjusted for age, place of residence in Sweden, educational level, marital status, neighbourhood socio-economic status and co-morbidities. The risk of gout varied by country of origin, with highest estimates, compared to Swedish born, in fully adjusted models among men from Iraq (HR 1.82, 95% CI 1.54-2.16), and Russia (HR 1.69, 95% CI 1.26-2.27), and also high among men from Austria, Poland, Africa and Asian countries outside the Middle East; and among women from Africa (HR 2.23, 95% CI 1.50-3.31), Hungary (HR 1.98, 95% CI 1.45-2.71), Iraq (HR 1.76, 95% CI 1.13-2.74) and Austria (HR 1.70, 95% CI 1.07-2.70), and also high among women from Poland. The risk of gout was lower among men from Greece, Spain, Nordic countries (except Finland) and Latin America and among women from Southern Europe, compared to their Swedish counterparts. The increased risk of gout among several immigrant groups is likely explained by a high cardio-metabolic risk factor pattern needing attention.

  • 456.
    Wandell, Per
    et al.
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med, S-14183 Huddinge, Sweden.;Stockholm Cty Council, Acad Primary Healthcare Ctr, Huddinge, Sweden..
    Carlsson, Axel C.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med, S-14183 Huddinge, Sweden..
    Ljunggren, Gunnar
    Stockholm Cty Council, Publ Healthcare Serv Comm Adm, SE-10239 Stockholm, Sweden.;Karolinska Inst, Med Management Ctr, Dept Learning Informat Management & Eth, SE-17177 Stockholm, Sweden..
    Gout and its comorbidities in the total population of Stockholm2015In: Preventive Medicine, ISSN 0091-7435, E-ISSN 1096-0260, Vol. 81, p. 387-391Article in journal (Refereed)
    Abstract [en]

    Objective. Study of prevalence of gout with concomitant diseases. Methods. Study population included all living persons in Stockholm County, Sweden, on January 1st 2013 (N = 2,124,959). A diagnosis of gout was identified during 2013-2014, with information of diabetes mellitus and insulin resistance, hypertension, chronic heart failure, chronic kidney disease, alcohol abuse, and malignancies. Age-adjusted odds ratios (ORs) with 95% confidence intervals (95% CI) for women and men with gout, using individuals without gout as referents, were calculated. Results. Age-adjusted odds of co-morbidities among individuals with gout vs. those without goutwere: diabetes mellitus and insulin resistance 3.97 (95% CI 3.65-4.31) in women and 1.88 (95% CI 1.78-1.99) in men; hypertension 4.02 (95% CI 3.69-4.37) inwomen and 3.21 (95% CI 3.06-3.37) in men; chronic heart failure 4.72 (95% CI 4.31-5.19) in women and 2.84 (95% CI 2.66-3.04) inmen; chronic kidney disease 2.08 (95% CI 1.50-2.87) in women and 2.39 (95% CI 2.15-2.66) in men; alcohol abuse 8.98 (95% CI 8.15-9.80) in women and 4.38 (95% CI 4.10-4.69) in men; and malignancies 1.32 (95% CI 1.17-1.48) in women and 1.13 (95% CI 1.06-1.21) men. Conclusion. Gout is a warning sign for concomitant diseases, e.g. alcoholism, diabetes, cardiovascular diseases, and cancer. Key messages. 1. A diagnosis of gout was present in 0.3% among women and 0.8% among men in Stockholm County. 2. Among individuals with gout, hypertension, being the most common concomitant disease, was present in 68% among women and 54% among men. 3. Alcohol abuse was the most overrepresented disorder compared to individuals without gout, with odds ratio of 9 among women and 5 among men.

  • 457.
    Wandell, Per
    et al.
    Karolinska Inst, Div Family Med, NVS Dept, Alfred Nobels Alle 23, S-14183 Huddinge, Sweden;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden.
    Carlsson, Axel C.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. UpKarolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden.
    Sundquist, Jan
    Shimane Univ, Sch Med, Dept Funct Pathol, Ctr Community Based Healthcare Res & Educ CoHRE, Matsue, Shimane, Japan;Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden;Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Family Med & Community Hlth, New York, NY 10029 USA.
    Sundquist, Kristina
    Shimane Univ, Sch Med, Dept Funct Pathol, Ctr Community Based Healthcare Res & Educ CoHRE, Matsue, Shimane, Japan;Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden;Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Family Med & Community Hlth, New York, NY 10029 USA.
    The association between relevant comorbidities and dementia in patients with atrial fibrillation2018In: GEROSCIENCE, ISSN 2509-2715, Vol. 40, no 3, p. 317-324Article in journal (Refereed)
    Abstract [en]

    Risk of dementia is increased in patients with atrial fibrillation (AF). We aimed to study associations between relevant comorbidities and prevalent as well as incident dementia in AF patients. Study population included all adults (n = 12,283) >= 45 years diagnosed with AF at 75 primary care centers in Sweden 2001-2007. Logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (95% CI) for associations between comorbidities and prevalent dementia. In a subsample (n = 12,096), (excluding patients with dementia diagnosed before AF onset), Cox regression was used to estimate hazard ratios (HR) with 95% CIs for association between comorbidities, and incident dementia, after adjustment for age, socioeconomic factors and anticoagulant treatment. Totally 937 patients (7.6%), 388 men (5.8%) and 549 women (9.7%), were diagnosed with dementia. After adjustments, prevalent dementia was more common in (ORs, 95% CI) men with congestive heart failure (CHF), stroke, and depression; in women with CHF and depression, and among women > 75 years with stroke, but less common in women with hypertension. During a 5.6-year follow-up (standard deviation 2.5), 750 patients (6.2%; 322 men, 4.9%, and 428 women, 7.8%) were diagnosed with incident dementia. An increased risk of incident dementia was found among men with diabetes and depression; a decreased risk among men and women with CHF, and among women with hypertension, myocardial infarction cerebrovascular diseases. The findings regarding incident dementia need to be interpreted with great caution, as they may have been subject to survival bias.

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  • 458. Wandell, Per E.
    et al.
    Carlsson, Axel C.
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Gender differences and time trends in incidence and prevalence of type 2 diabetes in Sweden: A model explaining the diabetes epidemic worldwide today?2014In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 106, no 3, p. E90-E92Article in journal (Refereed)
    Abstract [en]

    Gender differences in type 2 diabetes in Sweden were studied based on a literature search. The male predominance in 1940s (male/female ratio 1.2-1.4 in the ages 10-55 years) increased over time especially in the age 45-64 years with a male/female ratio up to 2.

  • 459. Wandell, Per Erik
    et al.
    Carlsson, Axel Carl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Sundquist, Jan
    Johansson, Sven-Erik
    Bottai, Matteo
    Sundquist, Kristina
    Pharmacotherapy and mortality in atrial fibrillation: a cohort of men and women 75 years or older in Sweden2015In: Age and Ageing, ISSN 0002-0729, E-ISSN 1468-2834, Vol. 44, no 2, p. 232-238Article in journal (Refereed)
    Abstract [en]

    Background: atrial fibrillation (AF) is a common cardiovascular morbidity, not least among elderly people, and is treated with different classes of cardiovascular pharmacotherapies. Hypothesis: cardiovascular drugs may have a different impact on survival in elderly patients with AF in primary health care. Methods: a cohort of 3,020 men and 3,749 women aged a parts per thousand yen75 and diagnosed with AF were selected from 75 primary care centres in Sweden. Laplace regression was used with years to death of the first 10% of the participants as the outcome. Independent variables were prescribed cardiovascular drugs. Regression models were adjusted for a propensity score comprising age, cardiovascular co-morbidities, socio-economic factors and other cardiovascular pharmacotherapies. Results: overall, mortality was 18.2%. The main finding of this study was survival increases associated with anticoagulants versus no treatment and versus antiplatelets of 1.95 years (95% confidence interval (CI) 1.43-2.48) and 0.78 years (95% CI 0.38-1.18), respectively, and survival increases associated with thiazides and calcium channel blockers of 0.81 years (95% CI 0.43-1.18) and 0.83 years (95% CI 0.47-1.18), respectively, in men and women together (results from sex-adjusted models). Conclusion: our findings suggest that anticoagulants, thiazides and calcium channel blockers may lead to longer survival in elderly patients with AF.

  • 460.
    Wang, Haidong
    et al.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Bhutta, Zulfiriar A.
    Aga Khan Univ, Ctr Excellence Women & Child Hlth, Karachi, Pakistan.;Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Coates, Matthew M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Coggeshall, Megan
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Dandona, Lalit
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Publ Hlth Fdn India, New Delhi, India..
    Diallo, Khassoum
    WHO Reg Off Europe, Copenhagen, Denmark..
    Franca, Elisabeth Barboza
    Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil..
    Fraser, Maya
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Fullman, Nancy
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Gething, Peter W.
    Univ Oxford, Dept Zool, Oxford, England..
    Hay, Simon I.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kinfu, Yohannes
    Univ Canberra, Fac Hlth, Ctr Res & Act Publ Hlth, Canberra, ACT, Australia..
    Kita, Maaya
    Univ Tokyo, Grad Sch Med, Dept Global Hlth Policy, Tokyo, Japan..
    Kulikoff, Xie Rachel
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Larson, Heidi J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London, England..
    Liang, Juan
    Sichuan Univ, West China Univ Hosp 2, Natl Off Maternal & Child Hlth Surveillance, Chengdu, Peoples R China..
    Liang, Xiaofeng
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Lind, Margaret
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Lopez, Alan D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia..
    Lozano, Rafael
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Mensah, George A.
    NHLBI, Ctr Translat Res & Implementat Sci, NIH, Bldg 10, Bethesda, MD 20892 USA..
    Mikesell, Joseph B.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Mokdad, Ali H.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Mooney, Meghan D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Nguyen, Grant
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Rakovac, Ivo
    WHO Reg Off Europe, Copenhagen, Denmark..
    Salomon, Joshua A.
    Harvard Univ, Dept Global Hlth & Populat, Boston, MA 02115 USA..
    Silpakit, Naris
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Sligar, Amber
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Sorensen, Reed J. D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Vos, Theo
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Zhu, Jun
    Natl Off MCH Surveillance China, Chengdu, Peoples R China..
    Abajobir, Amanuel Alemu
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Univ Queensland, Sch Publ Hlth, Herston, Qld, Australia..
    Abate, Kalkidan Hassen
    Jimma Univ, Jimma, Ethiopia..
    Abbas, Kaja M.
    Virginia Tech, Blacksburg, VA USA..
    Abd-Allah, Foad
    Cairo Univ, Dept Neurol, Cairo, Egypt..
    Abdulle, Abdishakur M.
    New York Univ Abu Dhabi, Abu Dhabi, U Arab Emirates..
    Abera, Semaw Ferede
    Mekelle Univ, Coll Hlth Sci, Mekelle, Ethiopia.;Kilte AwlaeloHealth & Demog Surveillance Site, Mekelle, Ethiopia.;Univ Hohenheim, Food Secur, Stuttgart, Germany.;Univ Hohenheim, Inst Biol Chem & Nutr, Stuttgart, Germany..
    Aboyans, Victor
    Dupuytren Univ Hosp, Limoges, France..
    Abraham, Biju
    NMSM Govt Coll Kalpetta, Kalpetta, Kerala, India..
    Abubakar, Ibrahim
    UCL, Inst Global Hlth, London, England..
    Abu-Raddad, Laith J.
    Weill Cornell Med Coll Qatar, Infect Dis Epidemiol Grp, Doha, Qatar..
    Abu-Rmeileh, Niveen M. E.
    Birzeit Univ, Inst Community & Publ Hlth, Ramallah, Israel..
    Abyu, Gebre Yitayih
    Mekelle Univ, Mekelle, Ethiopia..
    Achoki, Tom
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Adebiyi, Akindele Olupelumi
    Univ Ibadan, Coll Med, Ibadan, Nigeria.;Univ Coll Hosp, Ibadan, Nigeria..
    Adedeji, Isaac Akinkunmi
    Olabisi Onabanjo Univ, Ago Iwoye, Nigeria..
    Adelekan, Ademola Lukman
    Univ Ibadan, Ibadan, Nigeria.;Publ Hlth Promot Alliance, Osogbo, Nigeria..
    Adou, Arsene Kouablan
    Assoc Ivoirienne Bien Etre Familial, Abidjan, Cote Ivoire..
    Agarwal, Arnav
    Univ Toronto, Toronto, ON, Canada.;McMaster Univ, Hamilton, ON, Canada..
    Ajala, Oluremi N.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Univ Pittsburgh, Med Ctr, Mckeesport, PA USA..
    Akinyemiju, Tomi F.
    Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA..
    Akseer, Nadia
    Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada.;Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada..
    Alam, Khurshid
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.;Univ Sydney, Sydney, NSW, Australia..
    Alam, Noore K. M.
    Queensland Hlth, Herston, Qld, Australia.;Univ Queensland, Herston, Qld, Australia..
    Alasfoor, Deena
    Minist Hlth, Al Khuwair, Oman..
    Aldridge, Robert William
    UCL, Ctr Publ Hlth Data Sci, Inst Hlth Informat, London, England..
    Alegretti, Miguel Angel
    Univ Republica, Fac Med, Dept Prevent & Social Med, Montevideo, Uruguay..
    Alemu, Zewdie Aderaw
    Debre Markos Univ, Debre Markos, Ethiopia..
    Ali, Raghib
    Univ Oxford, Oxford, England..
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Strassen, Luxembourg..
    Alla, Francois
    Univ Lorraine, Sch Publ Hlth, Nancy, France..
    Al-Raddadi, Rajaa
    Minist Hlth, Jeddah, Saudi Arabia..
    Alsharif, Ubai
    Charite, Berlin, Germany..
    Altirkawi, Khalid A.
    King Saud Univ, Riyadh, Saudi Arabia..
    Martin, Elena Alvarez
    Minist Hlth Social Policy & Equal, Spanish Observ Drugs, Govt Delegat Natl Plan Drugs, Madrid, Spain..
    Alvis-Guzman, Nelson
    Univ Cartagena, Cartagena De Indias, Colombia..
    Amare, Azmeraw T.
    Univ Adelaide, Sch Med, Adelaide, SA, Australia.;Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia..
    Amberbir, Alemayehu
    Dignitas Int, Zomba, Malawi..
    Amegah, Adeladza Kofi
    Univ Cape Coast, Cape Coast, Ghana..
    Ameh, Emmanuel A.
    Natl Hosp, Abuja, Nigeria..
    Ammar, Walid
    Minist Publ Hlth, Beirut, Lebanon..
    Amrock, Stephen Marc
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Andersen, Hjalte H.
    Anderson, Gregory M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Aalborg Univ, Fac Med, Dept Hlth Sci & Technol, Ctr Sensory Motor Interact, Aalborg, Denmark..
    Antonio, Carl Abelardo T.
    Univ Philippines, Coll Publ Hlth, Dept Hlth Policy & Adm, Manila, Philippines..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Falun, Sweden..
    Artaman, Al
    Asayesh, Hamid
    Qom Univ Med Sci, Sch Paramed, Dept Emergency Med, Qom, Iran..
    Asghar, Rana Jawad
    South Asian Publ Hlth Forum, Islamabad, Pakistan..
    Assadi, Reza
    Atique, Suleman
    Avokpaho, Euripide Frinel G. Arthur
    Awasthi, Ashish
    Quintanilla, Beatriz Paulina Ayala
    Bacha, Umar
    Badawi, Alaa
    Univ Toronto, Dept Nutr Sci, Fac Med, Toronto, ON, Canada..
    Balakrishnan, Kalpana
    Banerjee, Amitava
    UCL, Farr Inst Hlth Informat Res, London, England..
    Banigbe, Bolanle F.
    Barac, Aleksandra
    Barber, Ryan M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Barker-Collo, Suzanne L.
    Barnighausen, Till
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Barrero, Lope H.
    Bayou, Tigist Assefa
    Mekelle Univ, Mekelle, Ethiopia..
    Bayou, Yibeltal Tebekaw
    Bazargan-Hejazi, Shahrzad
    Beardsley, Justin
    Bedi, Neeraj
    Bekele, Tolesa
    Bell, Michelle L.
    Bello, Aminu K.
    Bennett, Derrick A.
    Univ Oxford, Oxford, England..
    Bensenor, Isabela M.
    Berhane, Adugnaw
    Bernabe, Eduardo
    Betsu, Balem Demtsu
    Mekelle Univ, Mekelle, Ethiopia..
    Bhatt, Samir
    Biadgilign, Sibhatu
    Bikbov, Boris
    Birlik, Sait Mentes
    Bisanzio, Donal
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Bjertness, Espen
    Blore, Jed D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Bourne, Rupert R. A.
    Brainin, Michael
    Brazinova, Alexandra
    Breitborde, Nicholas J. K.
    Brown, Alexandria
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Buckle, Geoffrey Colin
    Burch, Michael
    Butt, Zahid A.
    Campos-Nonato, Ismael Ricardo
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico.;Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Campuzano, Julio Cesar
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Cardenas, Rosario
    Carpenter, David
    Carrero, Juan Jesus
    Carter, Austin
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Casey, Daniel C.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Castaneda-Oquela, Carlos A.
    Rivas, Jacqueline Castillo
    Castro, Ruben Estanislao
    Catala-Lopez, Ferran
    Cercy, Kelly
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Chang, Hsing-Yi
    Chang, Jung-Chen
    Chibueze, Chioma Ezinne
    Chisumpa, Vesper Hichilombwe
    Choi, Jee-Young Jasmine
    Chowdhury, Rajiv
    Christopher, Devasahayam Jesudas
    Ciobanu, Liliana G.
    Univ Adelaide, Adelaide, SA, Australia..
    Colquhoun, Samantha M.
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Cooper, Cyrus
    Univ Oxford, NIHR Musculoskeletal Biomed Res Ctr, Oxford, England..
    Cornaby, Leslie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Damtew, Solomon Abrha
    Danawi, Hadi
    Dandona, Rakhi
    Publ Hlth Fdn India, New Delhi, India..
    das Neves, Jose
    Davis, Adrian C.
    de Jager, Pieter
    De Leo, Diego
    Degenhardt, Louisa
    Deribe, Kebede
    Deribew, Amare
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Jarlais, Don C. Des
    deVeber, Gabrielle A.
    Hosp Sick Children, Toronto, ON, Canada..
    Dharmaratne, Samath D.
    Dhillon, Preet K.
    Ding, Eric L.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Doshi, Pratik Pinal
    Doyle, Kerrie E.
    Duan, Leilei
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Dubey, Manisha
    Ebrahimi, Hedyeh
    Ellingsen, Christian Lycke
    Elyazar, Iqbal
    Endries, Aman Yesuf
    Ermakov, Sergey Petrovich
    Eshrati, Babak
    Esteghamati, Alireza
    Faraon, Emerito Jose Aquino
    Univ Philippines, Coll Publ Hlth, Manila, Philippines..
    Farid, Talha A.
    Farinha, Carla Sofia e Sa
    Faro, Andre
    Farvid, Maryam S.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Farzadfar, Farshad
    Fereshtehnejad, Seyed-Mohammad
    Fernandes, Joao C.
    Fischer, Florian
    Fitchett, Joseph R. A.
    Harvard Univ, Boston, MA 02115 USA..
    Foigt, Nataliya
    Franklin, Richard C.
    Friedman, Joseph
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Furst, Thomas
    Gambashidze, Ketevan
    Gamkrelidze, Amiran
    Ganguly, Parthasarathi
    Gebre, Teshome
    Gebrehiwot, Tsegaye Tewelde
    Jimma Univ, Jimma, Ethiopia..
    Gebremedhin, Amanuel Tesfay
    Jimma Univ, Jimma, Ethiopia..
    Gebru, Alemseged Aregay
    Mekelle Univ, Mekelle, Ethiopia..
    Gelefinse, Johanna M.
    Gessner, Bradford D.
    Ginawi, Ibrahim Abdelmageem Mohamed
    Giref, Ababi Zergaw
    Gishu, Melkamu Dedefo
    Gomez-Dantes, Hector
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Gona, Philimon
    Goodridge, Amador
    Gopalani, Sameer Vali
    Goto, Atsushi
    Gouda, Hebe N.
    Univ Queensland, Brisbane, Qld, Australia..
    Gugnani, Harish Chander
    Guo, Yuming
    Univ Queensland, Brisbane, Qld, Australia..
    Gupta, Rahul
    Gupta, Rajeev
    Gupta, Vipin
    Gyawali, Bishal
    Haagsma, Juanita A.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Hafezi-Nejad, Nima
    Haile, Demewoz
    Hailu, Alemayehu Desalegne
    Hailu, Gessessew Bugssa
    Mekelle Univ, Mekelle, Ethiopia..
    Hamadeh, Randah Ribhi
    Hancock, Jamie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Handal, Alexis J.
    Hankey, Graeme J.
    Harb, Hilda L.
    Minist Publ Hlth, Beirut, Lebanon..
    Harikrishnan, Sivadasanpillai
    Harun, Kimani M.
    Havmoeller, Rasmus
    Hay, Roderick J.
    Heredia-Pi, Ileana Beatriz
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Hoek, Hans W.
    Horino, Masako
    Horita, Nobuyuki
    Hosgood, H. Dean
    Hotez, Peter J.
    Hoy, Damian G.
    Hsairi, Mohamed
    Hu, Guoqing
    Huang, Cheng
    Huang, John J.
    Huang, Hsiang
    Huiart, Laetitia
    Iburg, Kim Moesgaard
    Idrisov, Bulat T.
    Innos, Kaire
    Jacobsen, Kathryn H.
    Jahanmehr, Nader
    Javanbakht, Mehdi
    Jayatilleke, Achala Upendra
    Jee, Sun Ha
    Jeemon, Panniyammakal
    Publ Hlth Fdn India, Ctr Control Chron Condit, New Delhi, India..
    Jha, Vivekanand
    Univ Oxford, Oxford, England..
    Jiang, Guohong
    Jiang, Ying
    Jibat, Tariku
    Jin, Ye
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Jonas, Jost B.
    Kabir, Zubair
    Kalkonde, Yogeshwar
    Karnak, Ritul
    Kan, Haidong
    Kang, Gagandeep
    Karch, Andre
    Karema, Corine Kakizi
    Kasaeian, Amir
    Kaul, Anil
    Kawakami, Norito
    Univ Tokyo, Sch Publ Hlth, Tokyo, Japan..
    Kayibanda, Jeanne Francoise
    Kazanjan, Konstantin
    Keiyoro, Peter Njenga
    Kemp, Andrew Haddon
    Kengne, Andre Pascal
    Keren, Andre
    Kereselidze, Maia
    Kesavachandran, Chandrasekharan Nair
    Khader, Yousef Saleh
    Khalil, Ibrahim A.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Khan, Abdur Rahman
    Khan, Ejaz Ahmad
    Khang, Young -Ho
    Khonelidze, Irma
    Khubchandani, Jagdish
    Kim, Cho-il
    Kim, Daniel
    Kim, Yun Jin
    Kissoon, Niranjan
    Kivipelto, Miia
    Knibbs, Luke D.
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Univ Queensland, Sch Publ Hlth, Herston, Qld, Australia..
    Kokubo, Yoshihiro
    Kosen, Soewarta
    Koul, Parvaiz A.
    Koyanagi, Ai
    Defo, Barthelemy Kuate
    Bicer, Burcu Kucuk
    Kudom, Andreas A.
    Univ Cape Coast, Cape Coast, Ghana..
    Kumar, G. Anil
    Publ Hlth Fdn India, New Delhi, India..
    Kyu, Hmwe H.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Lal, Dharmesh Kumar
    Lalloo, Ratilal
    Univ Queensland, Sch Dent, Brisbane, Qld, Australia.;Univ Queensland, Sch Dent, Herston, Qld, Australia..
    Lam, Hilton
    Lam, Jennifer O.
    Lansingh, Van C.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Leigh, James
    Univ Sydney, Sydney, NSW, Australia..
    Leung, Ricky
    Li, Yichong
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Li, Yongmei
    Lindsay, M. Patrice
    Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada..
    Liu, Patrick Y.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Liu, Shiwei
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Lloyd, Belinda K.
    Lo, Warren D.
    Logroscino, Giancarlo
    Low, Nicola
    Lunevicius, Raimundas
    Lyons, Ronan A.
    Ma, Stefan
    Abd El Razek, Hassan Magdy
    Abd El Razek, Mohammed Magdy
    Mandavi, Mandi
    Majdan, Marek
    Majeed, Azeem
    Malekzadeh, Reza
    Mapoma, Chabila C.
    Marcenes, Wagner
    -Raga, Jose Martinez
    Marzan, Melvin Barrientos
    Masiye, Felix
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    McGrath, John J.
    Univ Queensland, Brisbane, Qld, Australia..
    Meaney, Peter A.
    Mehari, Alem
    Mehndiratta, Man Mohan
    Mekonnen, Alemayehu B.
    Univ Sydney, Sydney, NSW, Australia..
    Melaku, Yohannes Adama
    Mekelle Univ, Sch Publ Hlth, Mekelle, Ethiopia.;Univ Adelaide, Sch Med, Adelaide, SA, Australia..
    Memiah, Peter
    Memish, Ziad A.
    Mendoza, Walter
    Meretoja, Atte
    Univ Melbourne, Dept Med, Melbourne, Vic, Australia..
    Meretoja, Tuomo J.
    Mhimbira, Francis Apolinary
    Miller, Ted R.
    Mills, Edward J.
    Mirarefin, Mojde
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Misganaw, Awoke
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Mock, Charles N.
    Univ Washington, Harborview Injury Prevent & Res Ctr, Seattle, WA 98195 USA..
    Mohammad, Karzan Abdulmuhsin
    Mohammadi, Alireza
    Mohammed, Shafiu
    Monasta, Lorenzo
    Montanez Hernandez, Julio Cesar
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Montico, Marcella
    Moore, Ami R.
    Moradi-Lakeh, Maziar
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Morawska, Lidia
    Mori, Rintaro
    Mueller, Ulrich O.
    Murphy, Georgina A. V.
    Univ Oxford, Oxford, England..
    Murthy, Srinivas
    Nachega, Jean B.
    Naheed, Aliya
    Naidoo, Kovin S.
    Naldi, Luigi
    Nand, Devina
    Nangia, Vinay
    Neupane, Subas
    Newton, Charles R.
    Newton, John N.
    Ng, Marie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Ngalesoni, Frida Namnyak
    Nguhiu, Peter
    Nguyen, Quyen Le
    Nisar, Muhammad Imran
    Aga Khan Univ, Karachi, Pakistan..
    Pete, Patrick Martial Nkamedjie
    Norheim, Ole F.
    Norman, Rosana E.
    Ogbo, Felix Akpojene
    Oh, In-Hwan
    Ojelabi, Foluke Adetola
    Univ Ibadan, Ibadan, Nigeria..
    Olivares, Pedro R.
    Olusanya, Bolajoko Olubukunola
    Olusanya, Jacob Olusegun
    Oren, Eyal
    Ota, Erika
    Mahesh, P. A.
    Park, Eun-Kee
    Park, Hye-Youn
    Parsaeian, Mahboubeh
    Caicedo, Angel J. Paternina
    Patten, Scott B.
    Pedro, Joao Mario
    Pereira, David M.
    Perico, Norberto
    Pesudovs, Konrad
    Petzold, Max
    Phillips, Michael Robert
    Pillay, Julian David
    Pishgar, Farhad
    Polinder, Suzanne
    Pope, Daniel
    Popova, Svetlana
    Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON, Canada..
    Pourmalek, Farshad
    Qorbani, Mostafa
    Rabiee, Rynaz H. S.
    Rafay, Anwar
    Rahimi-Movaghar, Vafa
    Rahman, Mahfuzar
    Ur Rahman, Mohammad Hifz
    Ur Rahman, Sajjad
    Rai, Rajesh Kumar
    Raju, Murugesan
    Ram, Usha
    Rana, Saleem M.
    Ranabhat, Chhabi Lal
    Rao, Puja
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Refaat, Amany H.
    Remuzzi, Giuseppe
    Resnikoff, Serge
    Reynolds, Alex
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Rojas-Rueda, David
    Ronfani, Luca
    Roshandel, Gholamreza
    Roth, Gregory A.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Roy, Ambuj
    Ruhago, George Mugambage
    Sagar, Rajesh
    Saleh, Muhammad Muhammad
    Sanabria, Juan R.
    Sanchez-Nino, Maria Dolores
    Santos, Itamar S.
    Santos, Joao Vasco
    Sarmiento-Suarez, Rodrigo
    Sartorius, Benn
    Satpathy, Maheswar
    Savic, Miloje
    Sawhney, Monika
    Schneider, Ione J. C.
    Schottker, Ben
    Schwebel, David C.
    Univ Alabama Birmingham, Birmingham, AL USA..
    Seedat, Soraya
    Sepanlou, Sadaf G.
    Servan-Mori, Edson E.
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Setegn, Tesfaye
    Bahir Dar Univ, Bahir Dar, Ethiopia..
    Shahraz, Saeid
    Shaikh, Masood Ali
    Shakh-Nazarova, Marina
    Sharma, Rajesh
    She, Jun
    Sheikhbahaei, Sara
    Shen, Jiabin
    Sheth, Kevin N.
    Shibuya, Kenji
    Univ Tokyo, Grad Sch Med, Dept Global Hlth Policy, Tokyo, Japan..
    Shin, Hwashin Hyun
    Shin, Min-Jeong
    Shiri, Rahman
    Shuie, Ivy
    Sigfusdottir, Inga Dora
    Silva, Diego Augusto Santos
    Silverberg, Jonathan
    Simard, Edgar P.
    Sindi, Shireen
    Singh, Abhishek
    Singh, Jasvinder A.
    Univ Alabama Birmingham, Birmingham, AL USA..
    Singh, Om Prakash
    Singh, Prashant Kumar
    Singh, Virendra
    Soriano, Joan B.
    Soshnikov, Sergey
    Sposato, Luciano A.
    Sreeramareddy, Chandrashekhar T.
    Stathopoulou, Vasiliki
    Steel, Nicholas
    Stroumpoulis, Konstantinos
    Sturua, Lela
    Sunguya, Bruno F.
    Swaminathan, Soumya
    Sykes, Bryan L.
    Szoeke, Cassandra E. I.
    Univ Melbourne, Inst Hlth & Ageing, Melbourne, Vic, Australia..
    Tabares-Seisdedos, Rafael
    Tavakkoli, Mohammad
    Taye, Bineyam
    Tedla, Bemnet Amare
    Tefera, Worku Mekonnen
    Tekle, Tesfaye
    Mekelle Univ, Mekelle, Ethiopia..
    Shifa, Girma Temam
    Terkawi, Abdullah Sulieman
    Tesfay, Fisaha Haile
    Mekelle Univ, Coll Hlth Sci, Mekelle, Ethiopia..
    Tessema, Gizachew Assefa
    Univ Adelaide, Adelaide, SA, Australia..
    Thapa, Kiran
    Thomson, Alan J.
    -Lyman, Andrew L. Thorne
    Harvard Univ, Dept Nutr, Boston, MA 02115 USA..
    Tobe-Gai, Ruoyan
    Tonelli, Marcello
    Topor-Madry, Roman
    Topouzis, Fotis
    Tran, Bach Xuan
    Troeger, Christopher
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Truelsen, Thomas
    Dimbuene, Zacharie Tsala
    Tura, Abera Kenay
    Tyrovolas, Stefanos
    Ukwaja, Kingsley N.
    Uneke, Chigozie Jesse
    Uthman, Olalekan A.
    Vaezghasemi, Masoud
    Vasankari, Tommi
    Vasconcelos, Ana Maria Nogales
    Venketasubramanian, Narayanaswamy
    Verma, Raj Kumar
    Violante, Francesco S.
    Vladimirov, Sergey K.
    Vlassov, Vasiliy Victorovich
    Vollset, Stein Emil
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Wang, Linhong
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Wang, Yanping
    Weichenthal, Scott
    Weiderpass, Elisabete
    Weintraub, Robert G.
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Weiss, Daniel J.
    Univ Oxford, Oxford, England..
    Werdecker, Andrea
    Westerman, Ronny
    Widdowson, Marc -Alain
    Wijeratne, Tissa
    Univ Melbourne, Melbourne, Vic, Australia..
    Williams, Thomas Neil
    Wiysonge, Charles Shey
    Wolfe, Charles D. A.
    Wolfe, Ingrid
    Won, Sungho
    Wubshet, Mamo
    Xiao, Qingyang
    Xu, Gelin
    Yadav, Ajit Kumar
    Yakob, Bereket
    Yano, Yuichiro
    Yaseri, Mehdi
    Ye, Pengpeng
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Yebyo, Henock Gebremedhin
    Mekelle Univ, Mekelle, Ethiopia..
    Yip, Paul
    Yonemoto, Naohiro
    Yoon, Seok-Jun
    Younis, Mustafa Z.
    Yu, Chuanhua
    Zaidi, Zoubida
    Zaki, Maysaa El Sayed
    Zeeb, Hajo
    Zhang, Hao
    Zhao, Yong
    Zheng, Yingfeng
    Zhou, Maigeng
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Zodpey, Sanjay
    Murray, Christopher J. L.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 20152016In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 388, no 10053, p. 1725-1774Article in journal (Refereed)
    Abstract [en]

    Background

    Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in child mortality. The Global Burden of Disease 2015 Study (GBD 2015) provides an analytical framework to comprehensively assess these trends for under-5 mortality, age-specific and cause-specific mortality among children under 5 years, and stillbirths by geography over time.

    Methods

    Drawing from analytical approaches developed and refined in previous iterations of the GBD study, we generated updated estimates of child mortality by age group (neonatal, post-neonatal, ages 1-4 years, and under 5) for 195 countries and territories and selected subnational geographies, from 1980-2015. We also estimated numbers and rates of stillbirths for these geographies and years. Gaussian process regression with data source adjustments for sampling and non-sampling bias was applied to synthesise input data for under-5 mortality for each geography. Age-specific mortality estimates were generated through a two-stage age-sex splitting process, and stillbirth estimates were produced with a mixed-effects model, which accounted for variable stillbirth definitions and data source-specific biases. For GBD 2015, we did a series of novel analyses to systematically quantify the drivers of trends in child mortality across geographies. First, we assessed observed and expected levels and annualised rates of decrease for under-5 mortality and stillbirths as they related to the Soci-demographic Index (SDI). Second, we examined the ratio of recorded and expected levels of child mortality, on the basis of SDI, across geographies, as well as differences in recorded and expected annualised rates of change for under-5 mortality. Third, we analysed levels and cause compositions of under-5 mortality, across time and geographies, as they related to rising SDI. Finally, we decomposed the changes in under-5 mortality to changes in SDI at the global level, as well as changes in leading causes of under-5 deaths for countries and territories. We documented each step of the GBD 2015 child mortality estimation process, as well as data sources, in accordance with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER).

    Findings

    Globally, 5.8 million (95% uncertainty interval [UI] 5.7-6.0) children younger than 5 years died in 2015, representing a 52.0% (95% UI 50.7-53.3) decrease in the number of under-5 deaths since 1990. Neonatal deaths and stillbirths fell at a slower pace since 1990, decreasing by 42.4% (41.3-43.6) to 2.6 million (2.6-2.7) neonatal deaths and 47.0% (35.1-57.0) to 2.1 million (1.8-2.5) stillbirths in 2015. Between 1990 and 2015, global under-5 mortality decreased at an annualised rate of decrease of 3.0% (2.6-3.3), falling short of the 4.4% annualised rate of decrease required to achieve MDG4. During this time, 58 countries met or exceeded the pace of progress required to meet MDG4. Between 2000, the year MDG4 was formally enacted, and 2015, 28 additional countries that did not achieve the 4.4% rate of decrease from 1990 met the MDG4 pace of decrease. However, absolute levels of under-5 mortality remained high in many countries, with 11 countries still recording rates exceeding 100 per 1000 livebirths in 2015. Marked decreases in under-5 deaths due to a number of communicable diseases, including lower respiratory infections, diarrhoeal diseases, measles, and malaria, accounted for much of the progress in lowering overall under-5 mortality in low-income countries. Compared with gains achieved for infectious diseases and nutritional deficiencies, the persisting toll of neonatal conditions and congenital anomalies on child survival became evident, especially in low-income and low-middle-income countries. We found sizeable heterogeneities in comparing observed and expected rates of under-5 mortality, as well as differences in observed and expected rates of change for under-5 mortality. At the global level, we recorded a divergence in observed and expected levels of under-5 mortality starting in 2000, with the observed trend falling much faster than what was expected based on SDI through 2015. Between 2000 and 2015, the world recorded 10.3 million fewer under-5 deaths than expected on the basis of improving SDI alone.

    Interpretation

    Gains in child survival have been large, widespread, and in many places in the world, faster than what was anticipated based on improving levels of development. Yet some countries, particularly in sub-Saharan Africa, still had high rates of under-5 mortality in 2015. Unless these countries are able to accelerate reductions in child deaths at an extraordinary pace, their achievement of proposed SDG targets is unlikely. Improving the evidence base on drivers that might hasten the pace of progress for child survival, ranging from cost-effective intervention packages to innovative financing mechanisms, is vital to charting the pathways for ultimately ending preventable child deaths by 2030.

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  • 461.
    Wang, Haidong
    et al.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Naghavi, Mohsen
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
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    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Barber, Ryan M.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Bhutta, Zulfiqar A.
    Ctr Excellence Women & Child Hlth, Karachi, Pakistan.;Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Carter, Austin
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Casey, Daniel C.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Charlson, Fiona J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia..
    Chen, Alan Zian
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Coates, Matthew M.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Coggeshall, Megan
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Dandona, Lalit
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Publ Hlth Fdn India, New Delhi, India..
    Dicker, Daniel J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Erskine, Holly E.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia..
    Ferrari, Alize J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Fitzmaurice, Christina
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Foreman, Kyle
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Forouzanfar, Mohammad H.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Fraser, Maya S.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Pullman, Nancy
    Gething, Peter W.
    Dept Zool, Oxford, England..
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    Inst Hlth Metr & Evaluat, Seattle, WA USA..
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    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Haagsma, Juanita A.
    Univ Med Ctr, Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands..
    Hay, Simon I.
    Huynh, Chantal
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Johnson, Catherine
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Kassebaum, Nicholas J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Kinfu, Yohannes
    Univ Canberra, Fac Hlth, Ctr Res & Action Publ Hlth, Canberra, ACT, Australia..
    Kulikoff, Xie Rachel
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Kutz, Michael
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
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    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Larson, Heidi J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Dept Infect Dis Epidemiol, London, England..
    Leung, Janni
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia..
    Liang, Xiaofeng
    Chinese Ctr Dis Control, Beijing, Peoples R China..
    Lim, Stephen S.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Lind, Margaret
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Lozano, Rafael
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Marquez, Neal
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Mensah, George A.
    NHLBI, NIH, Ctr Translat Res & Implementat Sci, Bethesda, MD USA..
    Mikesell, Joe
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Mokdad, Ali H.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Mooney, Meghan D.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Nguyen, Grant
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Nsoesie, Elaine
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Pigott, David M.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Pinho, Christine
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Roth, Gregory A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Salomon, Joshua A.
    Dept Global Hlth & Populat, Boston, MA USA..
    Sandar, Logan
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Silpakit, Naris
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Sligar, Amber
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Sorensen, Reed J. D.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Stanaway, Jeffrey
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Steiner, Caitlyn
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Teeple, Stephanie
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Thomas, Bernadette A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Troeger, Christopher
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    VanderZanden, Amelia
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Vollset, Stein Emil
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Ctr Dis Burden, Oslo, Norway.;Dept Global Publ Hlth & Primary Care, Jimma, Ethiopia..
    Wanga, Valentine
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Whiteford, Harvey A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia..
    Wolock, Timothy
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Zoeckler, Leo
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Abate, Kalkidan Hassen
    Jimma Univ, Jimma, Ethiopia..
    Abbafati, Cristiana
    Univ Roma La Sapienza, Rome, Italy..
    Abbas, Kaja M.
    Virginia Tech, Blacksburg, VA USA..
    Abd-Allah, Foad
    Cairo Univ, Dept Neurol, Cairo, Egypt..
    Abera, Semaw Ferede
    Sch Publ Hlth, Coll Hlth Sci, Mekelle, Ethiopia.;Kilte AwlaeloHealth & Demog Surveillance Site, Mekelle, Ethiopia.;Univ Hohenheim, Food Secur & Inst Biol Chem & Nutr, Stuttgart, Germany.;Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil..
    Abreu, Daisy M. X.
    Abu-Raddad, Laith J.
    Weill Cornell Med Coll Qatar, Infect Dis Epidemiol Grp, Doha, Qatar..
    Abyu, Gebre Yitayih
    Mekelle Univ, Mekelle, Ethiopia..
    Achoki, Tom
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Adelekan, Ademola Lukman
    Publ Hlth Promot Alliance, Osogbo, Nigeria.;Univ Ibadan, Ibadan, Nigeria..
    Ademi, Zanfina
    Univ Basel, Basel, Switzerland.;Univ Melbourne, Melbourne, Vic, Australia..
    Adou, Arsene Kouablan
    Assoc Ivoirienne Bienetre Familial, Abidjan, Cote Ivoire..
    Adsuar, Jose C.
    Univ Extremadura, Caceres, Spain..
    Afanvi, Kossivi Agbelenko
    Direct Dist Sanitaire Haho, Notse, Togo.;Univ Lome, Fac Sci Sante, Lome, Togo..
    Afshin, Ashkan
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Agardh, Emilie Elisabet
    Inst Publ Hlth Sci, Stockholm, Sweden..
    Agarwal, Arnav
    Univ Toronto, Toronto, ON, Canada.;McMaster Univ, Hamilton, ON, Canada.;SIR Inst Genom & Integrat Biol, Delhi, India.;Baylor Coll Med, Dept Internal Med, Houston, TX USA..
    Agrawal, Anurag
    Kiadaliri, Aliasghar Ahmad
    Lund Univ, Orthoped Clin Epidemiol Unit, Dept Clin Sci Lund, Lund, Sweden.;Kerman Univ Med Sci, Inst Futures Studies Hlth, Hlth Serv Management Res Ctr, Kerman, Iran..
    Ajala, Oluremi N.
    Univ Pittsburgh, Med Ctr, McKeesport, PA USA..
    Akanda, All Shafqat
    Univ Rhode Isl, Kingston, RI USA..
    Akinyemi, Rufus Olusola
    Univ Ibadan, Ibadan, Nigeria.;Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England..
    Akinyemiju, Tomi F.
    Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA..
    Akseer, Nadia
    Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada.;Dalla Lana Sch Publ Hlth, Toronto, ON, Canada..
    Al Lami, Faris Hasan
    Baghdad Coll Med, Baghdad, Iraq..
    Alabed, Samer
    Univ Sheffield, Sheffield, S Yorkshire, England..
    Al-Aly, Ziyad
    Washington Univ, St Louis, MO USA..
    Alam, Khurshid
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Sydney, Sydney, NSW, Australia..
    Alam, Noore K. M.
    Univ Melbourne, Melbourne, Vic, Australia.;Queensland Hlth, Herston, Qld, Australia..
    Alasfoor, Deena
    Minist Hlth, Al Khuwair, Oman..
    Aldhahri, Saleh Fahed
    King Saud Univ, Riyadh, Saudi Arabia.;King Fahad Med City, Riyadh, Saudi Arabia..
    Aldridge, Robert William
    UCL, Inst Hlth Informat, Ctr Publ Hlth Data Sci, London, England.;UCL, Farr Inst Hlth Informat Res, London, England.;UCL, Inst Global Hlth, London, England..
    Alegretti, Miguel Angel
    Fac Med, Dept Prevent & Social Med, Montevideo, Uruguay..
    Aleman, Alicia V.
    Sch Med, Montevideo, Uruguay..
    Alemu, Zewdie Aderaw
    Debre Markos Univ, Debre, Markos, Ethiopia..
    Alexander, Lily T.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Alhabib, Samia
    King Abdullah Bin Abdulaziz Univ Hosp, Riyadh, Saudi Arabia..
    Ali, Raghib
    Univ Oxford, Oxford, England..
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Luxembourg, Luxembourg..
    Alla, Francois
    Univ Lorraine, Sch Publ Hlth, Nancy, France..
    Allebeck, Peter
    Dept Publ Hlth Sci, Stockholm, Sweden..
    Al-Raddadi, Rajaa
    Harvard T H Chan Sch Publ Hlth, Boston, MA USA.;Minist Hlth, Jeddah, Saudi Arabia..
    Alsharif, Ubai
    Charite, Berlin, Germany..
    Altirkawi, Khalid A.
    King Saud Univ, Riyadh, Saudi Arabia..
    Martin, Elena Alvarez
    Minist Hlth Social Policy & Equal, Spanish Observ Drugs Govt Delegat Natl Plan Drugs, Madrid, Spain..
    Alvis-Guzman, Nelson
    Univ Cartagena, Cartagena Indias, Colombia..
    Amare, Azmeraw T.
    Sch Med, Adelaide, SA, Australia.;Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia..
    Amegah, Adeladza Kofi
    Univ Cape Coast, Cape Coast, Ghana..
    Ameh, Emmanuel A.
    Natl Hosp, Abuja, Nigeria..
    Amini, Heresh
    Kurdistan Univ Med Sci, Environm Hlth Res Ctr, Sanandaj, Iran.;Dept Epidemiol & Publ Hlth, Basel, Switzerland..
    Ammar, Walid
    Minist Publ Hlth, Beirut, Lebanon..
    Amrock, Stephen Marc
    Oregon Hlth & Sci Univ, Portland, OR USA..
    Andersen, Hjalte H.
    Aalborg Univ, Fac Med, Dept Hlth Sci & Technol, Ctr Sensory Motor Interact, Aalborg, Denmark..
    Anderson, Benjamin
    Univ Washington, Seattle, WA 98195 USA..
    Anderson, Gregory M.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Antonio, Carl Abelardo T.
    Univ Philippines, Coll Publ Hlth, Dept Hlth Policy & Adm, Manila, Philippines. Univ Philippines, Coll Publ Hlth, Manila, Philippines..
    Aregay, Atsede Fantahun
    Mekelle Univ, Mekelle, Ethiopia..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Falun, Sweden..
    Arsenijevic, Valentina S. Arsic
    Univ Belgrade, Inst Microbiol & Immunol, Sch Med, Belgrade, Serbia.;Univ Children Hosp, Belgrade, Serbia..
    Artaman, Al
    Asayesh, Hamid
    Qom Univ Med Sci, Sch Paramed, Dept Emergency Med, Qom, Iran..
    Asghar, Rana Jawad
    South Asian Publ Hlth Forum, Islamabad, Pakistan..
    Atique, Suleman
    Taipei Med Univ, Grad Inst Biomed Informat, Taipei, Taiwan..
    Arthur Avokpaho, Euripide Frinel G.
    Inst Rech Clin Benin, Cotonou, Benin.;Lab Etud & Rech Act & Sante, Parakou, Benin..
    Awasthi, Ashish
    Sanjay Gandhi Postgrad Inst Med Sci, Lucknow, Uttar Pradesh, India..
    Azzopardi, Peter
    Dept Paediat, Melbourne, Vic, Australia.;Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;South Australian Hlth & Med Res Inst, Wardliparingga Aboriginal Res Unit, Adelaide, SA, Australia..
    Bacha, Umar
    Univ Management & Technol, Sch Hlth Sci, Lahore, Pakistan..
    Badawi, Alaa
    Fac Med, Dept Nutrit Sci, Toronto, ON, Canada.;Publ Hlth Agcy Canada, Toronto, ON, Canada..
    Bahit, Maria C.
    INECO Neurociencias, Rosario, Argentina..
    Balakrishnan, Kalpana
    Sri Ramachandra Univ, Dept Environm Hlth Engn, Chennai, Tamil Nadu, India..
    Banerjee, Amitava
    UCL, Farr Inst Hlth Informat Res, London, England..
    Barac, Aleksandra
    Univ Belgrade, Fac Med, Belgrade, Serbia..
    Barker-Collo, Suzanne L.
    Univ Auckland, Sch Psychol, Auckland, New Zealand..
    Barnighausen, Till
    Harvard T H Chan Sch Publ Hlth, Boston, MA USA.;Africa Hlth Res Inst, Mtubatuba, South Africa.;Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Barregard, Lars
    Univ Gothenburg, Dept Occupat & Environm Hlth, Gothenburg, Sweden..
    Barrero, Lope H.
    Pontificia Univ Javeriana, Sch Engn, Dept Ind Engn, Bogota, Colombia..
    Basu, Arindam
    Univ Canterbury, Sch Hlth Sci, Christchurch, New Zealand..
    Basu, Sanjay
    Stanford Univ, Stanford, CA USA..
    Bayou, Yibeltal Tebekaw
    Jhpiego Ethiopia, Addis Ababa, Ethiopia..
    Bazargan-Hejazi, Shahrzad
    Charles R Drew Univ Med & Sci, Coll Med, Los Angeles, CA USA.;Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.;Kermanshah Univ Med Sci, Kermanshah, Iran..
    Beardsley, Justin
    Univ Oxford, Ho Chi Minh City, Vietnam..
    Bedi, Neeraj
    Coll Publ Hlth & Trop Med, Jazan, Saudi Arabia..
    Beghi, Ettore
    IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy..
    Belay, Haileeyesus Adamu
    Univ Addis Ababa, Addis Ababa, Ethiopia..
    Bell, Brent
    Univ N Carolina, Chapel Hill, NC USA..
    Bell, Michelle L.
    Yale Univ, New Haven, CT USA..
    Bello, Aminu K.
    Univ Alberta, Edmonton, AB, Canada..
    Bennett, Derrick A.
    Univ Oxford, Oxford, England..
    Bensenor, Isabela M.
    Univ Sao Paulo, Sao Paulo, Brazil..
    Berhane, Adugnaw
    Debre Berhane Univ, Debre Berhan, Ethiopia..
    Bernabe, Eduardo
    Kings Coll London, London, England..
    Betsu, Balem Demtsu
    Mekelle Univ, Mekelle, Ethiopia..
    Beyene, Addisu Shunu
    Haramaya Univ, Harar, Ethiopia..
    Bhala, Neeraj
    Queen Elizabeth Hosp Birmingham, Birmingham, W Midlands, England.;Univ Otago, Sch Med, Wellington, New Zealand..
    Bhalla, Ashish
    Postgrad Inst Med Educ & Res, Chandigarh, India..
    Biadgilign, Sibhatu
    Independent Publ Hlth Consultants, Addis Ababa, Ethiopia..
    Bikbov, Boris
    Acad V I Shumakov Fed Res, Ctr Transplantol & Artificial Organs, Dept Nephrol Issues Transplanted Kidney, Moscow, Russia..
    Bin Abdulhak, Aref A.
    Univ Iowa, Hosp & Clin, Iowa City, IA USA..
    Biroscak, Brian J.
    Yale Univ, New Haven, CT USA.;Univ S Florida, Tampa, FL USA..
    Biryukov, Stan
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Bjertness, Espen
    Univ Oslo, Dept Community Med, Oslo, Norway..
    Blore, Jed D.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Blosser, Christopher D.
    Univ Washington, Seattle, WA 98195 USA..
    Bohensky, Megan A.
    Univ Melbourne, Melbourne, Vic, Australia..
    Borschmann, Rohan
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Bose, Dipan
    World Bank, Washington, DC USA..
    Bourne, Rupert R. A.
    Anglia Ruskin Univ, Vision & Eye Res Unit, Cambridge, England..
    Brainin, Michael
    Danube Univ Krems, Krems, Austria..
    Brayne, Carol E. G.
    Cambridge Inst Publ Hlth, Cambridge, England..
    Brazinova, Alexandra
    Trnava Univ, Dept Publ Hlth, Fac Hlth Sci & Social Work, Trnava, Slovakia.;Int Neurotrama Res Org, Vienna, Austria..
    Breitborde, Nicholas J. K.
    Ohio State Univ, Columbus, OH 43210 USA..
    Brenner, Hermann
    German Canc Res Ctr, Heidelberg, Germany..
    Brewer, Jerry D.
    Mayo Clin, Rochester, MN USA..
    Brown, Alexandria
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Brown, Jonathan
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Brugha, Traolach S.
    Univ Leicester, Leicester, Leics, England..
    Buckle, Geoffrey Colin
    Univ Calif San Francisco, San Francisco, CA 94143 USA..
    Butt, Zahid A.
    Shifa Trust Eye Hosp, Rawalpindi, Pakistan..
    Calabria, Bianca
    Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia.;Univ New South Wales, Sydney, NSW, Australia..
    Campos-Novato, Ismael Ricardo
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico.;Harvard T H Chan Sch Publ Hlth, Boston, MA USA..
    Campuzano, Julio Cesar
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Carapetis, Jonathan R.
    Univ Western Australia, Princess Margaret Hosp Children, Telethon Kids Inst, Subiaco, WA, Australia..
    Cardenas, Rosario
    Metropolitan Autonomous Univ, Mexico City, DF, Mexico..
    Carpenter, David
    SUNY Albany, Rensselaer, NY 12222 USA..
    Carrero, Juan Jesus
    Dept Clin Sci Intervent & Technol, Stockholm, Sweden..
    Castaneda-Oquela, Carlos A.
    Colombian Natl Hlth Observ, Inst Nacl Salud, Bogota, Colombia.;Univ Nacl Colombia, Dept Publ Hlth, Epidemiol & Publ Hlth Evaluat Grp, Bogota, Colombia..
    Rivas, Jacqueline Castillo
    Caja Costarricense Seguro Social, San Jose, Costa Rica.;Univ Costa Rica, San Pedro, Montes Oca, Costa Rica..
    Catala-Lopez, Ferran
    Univ Valencia, INCLIVA Hlth Res Inst & CIBERSAM, Dept Med, Valencia, Spain.;Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada..
    Cavalleri, Fiorella
    Fac Med, Montevideo, Uruguay..
    Cercy, Kelly
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Cerda, Jorge
    Albany Med Coll, Albany, NY 12208 USA..
    Chen, Wanqing
    Chinese Acad Med Sci, Inst Canc, Beijing, Peoples R China..
    Chew, Adrienne
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Chiang, Peggy Pei -Chia
    Gold Coast Hlth, Clin Governance Unit, Southport, Qld, Australia..
    Chibalabala, Mirriam
    Crowd Watch Afr, Lusaka, Zambia..
    Chibueze, Chioma Ezinne
    Natl Ctr Child Hlth & Dev, Tokyo, Japan..
    Chimed-Ochir, Odgerel
    Univ Occupat & Environm Hlth, Dept Environm Epidemiol, Kitakyushu, Fukuoka, Japan..
    Chisumpa, Vesper Hichilombwe
    Univ Zambia, Lusaka, Zambia.;Univ Witwatersrand, Johannesburg, South Africa..
    Choi, Jee-Young Jasmine
    Seoul Natl Univ Med Lib, Seoul, South Korea..
    Chowdhury, Rajiv
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Christensen, Hanne
    Bispebjerg Hosp, Copenhagen, Denmark..
    Christopher, Devasahayam Jesudas
    Christian Med Coll & Hosp, Vellore, Tamil Nadu, India..
    Ciobanu, Liliana G.
    Univ Adelaide, Adelaide, SA, Australia..
    Cirillo, Massimo
    Univ Salerno, Baronissi, Italy..
    Cohen, Aaron J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Hlth Effects Inst, Boston, MA USA..
    Colistro, Valentina
    Univ Republ Montevideo, Montevideo, Uruguay.;Minist Salud Publ, Montevideo, Uruguay..
    Colomar, Mercedes
    UNICEM, Montevideo, Uruguay..
    Colquhoun, Samantha M.
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Cooper, Cyrus
    NIHR Musculoskeletal Biomed Res Ctr, Oxford, England.;Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England.;Univ Southampton, NIHR Biomed Res Ctr, Southampton, Hants, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England..
    Cooper, Leslie Trumbull
    Mayo Clin, Jacksonville, FL 32224 USA..
    Cortinovis, Monica
    Mario Negri Inst Pharmacol Res, Milan, Italy..
    Cowie, Benjamin C.
    Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia.;WHO, Collaborating Ctr Viral Hepatitis, Victorian Infect Dis Reference Lab Melbourne, Melbourne, Vic, Australia..
    Crump, John A.
    Dunedin Sch Med, Ctr Int Hlth, Dunedin, New Zealand..
    Damsere-Derry, James
    Bldg & Rd Res Inst, Kumasi, Ghana..
    Danawi, Hadi
    Walden Univ, Minneapolis, MN USA..
    Dandona, Rakhi
    Publ Hlth Fdn India, New Delhi, India..
    Daoud, Farah
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Darby, Sarah C.
    Clin Trial Serv Unit, Oxford, England..
    Dargan, Paul I.
    Guys & St Thomas NHS Fdn Trust, London, England..
    das Neves, Jose
    Univ Porto, Inst Invest & Inovacao Saude I3S, Oporto, Portugal.;Univ Porto, INEB, Oporto, Portugal..
    Davey, Gail
    Wellcome Trust Brighton & Sussex, Ctr Global Hlth Res, Brighton, E Sussex, England..
    Davis, Adrian C.
    Publ Hlth England, London, England..
    Davitoiu, Dragos V.
    Univ Med Pharm Bucharest, Bucharest, Romania..
    de Castro, E. Filipa
    Natl Inst Publ Hlth, Mexico City, DF, Mexico..
    de Jager, Pieter
    Univ Witwatersrand, Sch Publ Hlth, Johannesburg, South Africa.;Natl Inst Occupat Hlth, Natl Hlth Lab Serv, Johannesburg, South Africa..
    De Leo, Diego
    Griffith Univ, Brisbane, Qld, Australia..
    Degenhardt, Louisa
    Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia..
    Dellavalle, Robert P.
    Univ Colorado, Sch Med, Aurora, CO USA.;Univ Colorado, Colorado Sch Publ Hlth, Aurora, CO USA..
    Deribe, Kebede
    Univ Addis Ababa, Sch Publ Hlth, Addis Ababa, Ethiopia.;Brighton & Sussex Med Sch, Brighton, E Sussex, England..
    Deribew, Amare
    Nuffield Dept Med, Oxford, England.;KEMRI Wellcome Trust Res Programme, Kilifi, Kenya..
    Dharmaratne, Samath D.
    Univ Peradeniya, Fac Med, Dept Community Med, Peradeniya, Sri Lanka..
    Dhillon, Preet K.
    Publ Hlth Fdn India, Gurgaon, India.;Publ Hlth Fdn India, Gurgaon, India..
    Diaz-Torne, Cesar
    Hosp Santa Creu i Sant Pau, Barcelona, Spain..
    Ding, Eric L.
    Harvard T H Chan Sch Publ Hlth, Boston, MA USA..
    dos Santos, Kadine Priscila Bender
    Univ Estado Santa Catarina, Florianopolis, SC, Brazil..
    Dossou, Edem
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Driscoll, Tim R.
    Sydney Sch Publ Hlth, Sydney, NSW, Australia..
    Duan, Leilei
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Dubey, Manisha
    Int Inst Populat Sci, Mumbai, Maharashtra, India..
    Bartholow, Bruce
    Ellenbogen, Richard G.
    Harborview UW Med, Seattle, WA USA..
    Lycke, Christian
    Elyazar, Iqbal
    Eijkman Oxford Clin Res Unit, Jakarta, Indonesia..
    Endries, Aman Yesuf
    Arba Minch Univ, Arba Minch, Ethiopia..
    Ermakov, Sergey Petrovich
    Russian Acad Sci, Inst Social & Econ Studies Populat, Moscow, Russia.;Russian Federat, Fed Res Inst Hlth Org & Informat, Minist Hlth, Moscow, Russia..
    Eshrati, Babak
    Minist Hlth & Med Educ, Tehran, Iran.;Arak Univ Med Sci, Arak, Iran..
    Esteghamati, Alireza
    Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Tehran, Iran..
    Estep, Kara
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Faghmous, Imad D. A.
    London Sch Hyg & Trop Med, London, England..
    Fahimi, Saman
    Univ Tehran Med Sci, Digest Dis Res Inst, Tehran, Iran..
    Jose, Emerito
    Farid, Talha A.
    Univ Louisville, Louisville, KY 40292 USA..
    Sa Farinha, Carla Sofia e
    DGS Directorate Gen Hlth, Lisbon, Portugal.;Univ Aberta, Lisbon, Portugal..
    Faro, Andre
    Univ Fed Sergipe, Aracaju, Brazil..
    Farvid, Maryam S.
    Harvard T H Chan Sch Publ Hlth, Boston, MA USA.;Massachusetts Gen Hosp, Harvard MGH Ctr Genom, Mongan Inst Hlth Policy, Vulnerable Populat, Boston, MA 02114 USA..
    Farzadfar, Farshad
    Univ Tehran Med Sci, Non Communicable Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran..
    Feigin, Valery L.
    Natl Inst Stroke & Appl Neurosci, Auckland, New Zealand..
    Fereshtehnejad, Seyed-Mohammad
    Dept Neurobiol Care Sci & Soc, Stockholm, Sweden..
    Fernandes, Jefferson G.
    German Hosp Oswaldo Cruz, Inst Sci Educ, Sao Paulo, Brazil..
    Fernandes, Joao C.
    Queen Mary Univ London, Ctr Expt Med & Rheumatol, William Harvey Res Inst, Barts & London Sch Med & Dent, London, England..
    Fischer, Florian
    Univ Bielefeld, Bielefeld, Germany..
    Fitchett, Joseph R. A.
    Harvard Univ, Boston, MA 02115 USA..
    Flaxman, Abraham
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Foigt, Nataliya
    Acad Med Sci, Inst Gerontol, Kiev, Ukraine..
    Fowkes, F. Gerry R.
    Univ Edinburgh, Edinburgh, Midlothian, Scotland..
    Franca, Elisabeth Barboza
    Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil..
    Franklin, Richard C.
    James Cook Univ, Townsville, Qld, Australia..
    Friedman, Joseph
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Frostad, Joseph
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Hirst, Thomas
    Futran, Neal D.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Washington, Seattle, WA 98195 USA.;Imperial Coll London, Dept Infect Dis Epidemiol, London, England..
    Gall, Seana L.
    Univ Tasmania, Hobart, Tas, Australia..
    Gambashidze, Ketevan
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Gamkrelidze, Amiran
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Ganguly, Parthasarathi
    Publ Hlth Fdn India, Gurgaon, India.;Indian Inst Publ Hlth Gandhinagar, Ahmadabad, Gujarat, India.;Publ Hlth Fdn India, Gurgaon, India..
    Gankpe, Fortune Gbetoho
    Lab Etud & Rech Act & Sante, Parakou, Benin.;CHU Hassan II, Fes, Morocco..
    Gebre, Teshome
    Task Force Global Hlth, Decatur, GA USA..
    Gebrehiwot, Tsegaye Tsewelde
    Jimma Univ, Jimma, Ethiopia..
    Gebremedhin, Amanuel Tesfay
    Jimma Univ, Jimma, Ethiopia.;Ludwig Maximilians Univ Munchen, Munich, Germany..
    Gebru, Alemseged Aregay
    Mekelle Univ, Mekelle, Ethiopia.;Kilte Awlaelo Hlth & Demog Surveillance Syst, Mekelle, Ethiopia..
    Geleijnse, Johanna M.
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands..
    Gessner, Bradford D.
    Agence Med Prevent, Paris, France..
    Ghoshal, Aloke Gopal
    Natl Allergy Asthma Bronchitis Inst, Kolkata, India..
    Gibney, Katherine B.
    Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia.;Royal Melbourne Hosp, Melbourne, Vic, Australia..
    Gillum, Richard F.
    Howard Univ, Coll Med, Washington, DC 20059 USA..
    Gilmour, Stuart
    Univ Tokyo, Grad Sch Med, Tokyo, Japan..
    Giref, Ababi Zergaw
    Univ Addis Ababa, Addis Ababa, Ethiopia..
    Giroud, Maurice
    Univ Hosp Dijon, Dijon, France..
    Gishu, Melkamu Dedefo
    Haramaya Univ, Harar, Ethiopia.;Kersa Hlth & Demog Surveillance Syst, Harar, Ethiopia..
    Giussani, Giorgia
    Mario Negri Inst Pharmacol Res, Milan, Italy..
    Glaser, Elizabeth
    Brandeis Univ, Heller Sch Social Policy & Management, Waltham, MA USA..
    Godwin, William W.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Gomez-Dantes, Hector
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Gona, Philimon
    Univ Massachusetts, Boston, MA USA..
    Goodridge, Amador
    Inst Invest Cient & Serv Alta Tecnol INDICASAT AI, Ciudad Del Saber, Panama..
    Gopalani, Sameer Vali
    Govt Federated States Micronesia, Dept Hlth & Social Affairs, Palikir, Micronesia..
    Gosselin, Richard A.
    Univ Calif San Francisco, San Francisco, CA 94143 USA..
    Gotay, Carolyn C.
    Univ British Columbia, Vancouver, BC, Canada..
    Goto, Atsushi
    Ctr Publ Hlth Sci, Div Epidemiol, Tokyo, Japan..
    Gouda, Hebe N.
    Univ Queensland, Brisbane, Qld, Australia..
    Greaves, Felix
    Publ Hlth England, London, England.;Imperial Coll London, London, England..
    Gugnani, Harish Chander
    Dept St James Sch Med, Dept Microbiol, The Quarter, Anguilla, England.;Dept St James Sch Med, Dept Epidemiol & Biostat, The Quarter, Anguilla, England..
    Gupta, Rahul
    Gupta, Rajeev
    West Virginia Bur Publ Hlth, Charleston, WV USA.;Eternal Heart Care Ctr & Res Inst, Jaipur, Rajasthan, India..
    Gupta, Vipin
    Univ Delhi, Dept Anthropol, Delhi, India..
    Gutierrez, Reyna A.
    Natl Inst Psychiat Ramon Fuente, Mexico City, DF, Mexico..
    Hafezi-Nejad, Nima
    Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Tehran, Iran..
    Haile, Demewoz
    Univ Addis Ababa, Addis Ababa, Ethiopia..
    Hailu, Alemayehu Desalegne
    Univ Bergen, Bergen, Norway.;Univ Addis Ababa, Sch Publ Hlth, Addis Ababa, Ethiopia.;Kilte Awlaelo Hlth & Demog Surveillance Syst, Mekelle, Ethiopia..
    Hailu, Gessessew Bugssa
    Mekelle Univ, Mekelle, Ethiopia..
    Halasa, Yara A.
    Brandeis Univ, Waltham, MA USA..
    Hamadeh, Randah Ribhi
    Arabian Gulf Univ, Manama, Bahrain..
    Hamidi, Samer
    Hamdan Bin Mohammed Smart Univ, Dubai, U Arab Emirates..
    Hancock, Jamie
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Handal, Alexis J.
    Univ New Mexico, Albuquerque, NM 87131 USA..
    Hankey, Graeme J.
    Univ Western Australia, Sch Med & Pharmacol, Fremantle, WA, Australia.;Harry Perkins Inst Med Res, Nedlands, WA, Australia.;Western Australian Neurosci Res Inst, Nedlands, WA, Australia..
    Hao, Yuantao
    Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China..
    Harb, Hilda L.
    Minist Publ Hlth, Beirut, Lebanon..
    Harikrishnan, Sivadasanpillai
    Sree Chitra Tirunal Inst Med Sci & Technol, Trivandrum, Kerala, India..
    Haro, Josep Maria
    Parc Sanitari Sant Joan Deu CIBERSAM, Barcelona, Spain.;Univ Barcelona, Barcelona, Spain..
    Havmoeller, Rasmus
    Karolinska Inst, Stockholm, Sweden..
    Heckbert, Susan R.
    Univ Washington, Seattle, WA 98195 USA..
    Heredia-Pi, Ileana Beatriz
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Heydarpour, Pouria
    Univ Tehran Med Sci, Multiple Sclerosis Res Ctr, Neuroscience Inst, Tehran, Iran..
    Hilderink, Henk B. M.
    Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands..
    Hoek, Hans W.
    Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.;Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA..
    Hogg, Robert S.
    Simon Fraser Univ, Burnaby, BC, Canada.;BC Ctr Excellence HIV AIDS, Vancouver, BC, Canada..
    Horino, Masako
    Nevada Div Publ & Behav Hlth, Dept Hlth & Human Serv, Carson City, NV USA..
    Horita, Nobuyuki
    Yokohama City Univ Grad Sch Med, Dept Pulmonol, Yokohama, Kanagawa, Japan..
    Hosgood, H. Dean
    Albert Einstein Coll Med, Bronx, NY 10467 USA..
    Hotez, Peter J.
    Baylor Coll Med, Houston, TX USA..
    Hoy, Damian G.
    Pacific Commun, Publ Hlth Div, Noumea, New Caledonia..
    Hsairi, Mohamed
    Salah Azaiz Inst, Dept Epidemiol, Tunis, Tunisia..
    Htet, Aung Soe
    Univ Oslo, Oslo, Norway.;Minist Hlth, Int Relat Div, Nay Pyi Taw, Myanmar..
    Than Htike, Maung Maung
    Minist Hlth, Nay Pyi Taw, Myanmar..
    Hu, Guoqing
    Cent S Univ, Dept Epidemiol & Hlth Stat, Sch Publ Hlth, Changsha, Hunan, Peoples R China..
    Huang, Cheng
    George Washington Univ, Washington, DC USA..
    Huang, Hsiang
    Cambridge Hlth Alliance, Cambridge, MA USA..
    Huiart, Laetitia
    CHU Reunion, St Denis, France..
    Husseini, Abdullatif
    Birzeit Univ, Birzeit, Israel..
    Huybrechts, Inge
    IARC, Lyon, France.;Univ Ghent, Ghent, Belgium..
    Huynh, Grace
    Inst Dis Modeling, Bellevue, WA USA..
    Iburg, Kim Moesgaard
    Aarhus Univ, Aarhus, Denmark..
    Innos, Kaire
    Natl Inst Hlth Dev, Tallinn, Estonia..
    Inoue, Manami
    Univ Tokyo, Grad Sch Med, Tokyo, Japan.;Natl Canc Ctr, Tokyo, Japan..
    Iyer, Veena J.
    Indian Inst Publ Hlth Gandhinagar, Ahmadabad, Gujarat, India..
    Jacobs, Troy A.
    USAID Global Hlth Bur, MCH Div, HIDN, Washington, DC USA..
    Jacobsen, Kathryn H.
    George Mason Univ, Dept Global & Community Hlth, Fairfax, VA USA..
    Jahanmehr, Nader
    Shahid Beheshti Univ Med Sci, Sch Publ Hlth, Tehran, Iran..
    Jakovljevic, Mihajlo B.
    Univ Kragujevac, Fac Med Sci, Kragujevac, Serbia..
    James, Peter
    Channing Div Network Med, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA..
    Javanbakht, Mehdi
    Univ Aberdeen, Aberdeen, Scotland..
    Jayaraman, Sudha P.
    Virginia Commonwealth Univ, Dept Surg, Richmond, VA USA..
    Jayatilleke, Achala Upendra
    Postgrad Inst Med, Colombo, Sri Lanka.;Inst Violence & Injury Prevent, Colombo, Sri Lanka..
    Jeemon, Panniyammakal
    Ctr Control Chron Condit, Gurgaon, Haryana, India.;Ctr Control Chron Condit, Gurgaon, India.;Ctr Chron Dis Control, New Delhi, India..
    Jensen, Paul N.
    Univ Washington, Seattle, WA 98195 USA..
    Jha, Vivekanand
    Univ Oxford, Oxford, England.;George Inst Global Hlth India, New Delhi, India..
    Jiang, Guohong
    Tianjin Ctr Dis Control & Prevent, Tianjin, Tianjin, Peoples R China..
    Jiang, Ying
    Univ Occupat & Environm Hlth, Dept Hlth Dev, Inst Ind Ecol Sci, Kitakyushu, Fukuoka, Japan..
    Jibat, Tariku
    Univ Addis Ababa, Addis Ababa, Ethiopia.;Wageningen Univ, Wageningen, Netherlands..
    Jimenez-Corona, Aida
    Inst Ophthalmol Conde Valencia, Dept Ocular Epidemiol & Visual Hlth, Mexico City, DF, Mexico.;Gen Directorate Epidemiol, Minist Hlth, Mexico City, DF, Mexico..
    Jonas, Jost B.
    Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany..
    Joshi, Tushar Kant
    Ctr Occupat & Environm Hlth, New Delhi, India..
    Kabir, Zubair
    Natl Univ Ireland Univ Coll Cork, Cork, Ireland..
    Karnak, Ritul
    CSIR Indian Inst Toxicol Res, Lucknow, Uttar Pradesh, India..
    Kan, Haidong
    Fudan Univ, Shanghai, Peoples R China..
    Kant, Surya
    King Georges Med Univ, Lucknow, Uttar Pradesh, India..
    Karch, Andre
    Epidemiol & Stat Methods Res Grp, Helmholtz Ctr Infect Res, Braunschweig, Germany.;German Ctr Infect Res, Hannover Braunschweig Site, Braunschweig, Germany..
    Karema, Corine Kakizi
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland.;Qual & Equity Hlth Care, Kigali, Rwanda..
    Karimkhani, Chante
    Case Western Univ Hosp, Cleveland, OH USA..
    Karletsos, Dimitris
    Univ Pompeu Fabra, Ctr Res Hlth & Econ, Barcelona, Spain..
    Karthikeyan, Ganesan
    All India Inst Med Sci, New Delhi, India..
    Kasaeian, Amir
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Tehran Med Sci, Non Communicable Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.;Univ Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran..
    Katibeh, Marzieh
    Shahid Beheshti Univ Med Sci, Ophthalm Epidemiol Res Ctr, Tehran, Iran..
    Kaul, Anil
    Oklahoma State Univ, Tulsa, OK USA..
    Kawakami, Norito
    Univ Tokyo, Sch Publ Hlth, Tokyo, Japan..
    Kayibanda, Jeanne Francoise
    Inst Rech Ihopital Monttfort, Ottawa, ON, Canada..
    Keiyoro, Peter Njenga
    Inst Trop & Infect Dis, Nairobi, Kenya.;Sch Continuing & Distance Educ, Nairobi, Kenya..
    Kemmer, Laura
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Kemp, Andrew Haddon
    Univ Sydney, Sydney, NSW, Australia.;Swansea Univ, Swansea, W Glam, Wales..
    Kengne, Andre Pascal
    South African Med Res Council, Cape Town, South Africa.;Univ Cape Town, Cape Town, South Africa..
    Keren, Andre
    Assuta Hosp, Assuta Hashalom, Tel Aviv, Israel..
    Kereselidze, Maia
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Kesavachandran, Chandrasekharan Nair
    CSIR Indian Inst Toxicol Res, Lucknow, Uttar Pradesh, India..
    Khader, Yousef Saleh
    Jordan Univ Sci & Technol, Irbid, Jordan..
    Khalil, Ibrahim A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Khan, Abdur Rahman
    Univ Louisville, Louisville, KY 40292 USA..
    Khan, Ejaz Ahmad
    Hlth Serv Acad, Islamabad, Pakistan..
    Khang, Young-Ho
    Seoul Natl Univ, Coll Med, Seoul, South Korea..
    Khera, Sahil
    New York Med Coll, Valhalla, NY USA..
    Muthafer Khoja, Tawfik Ahmed
    Execut Board Hlth Ministers Council Cooperat Coun, Riyadh, Saudi Arabia..
    Kieling, Christian
    Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil.;Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.;Norwegian Inst Publ Hlth, Oslo, Norway..
    Kim, Daniel
    Kim, Yun Jin
    Northeastern Univ, Dept Hlth Sci, Boston, MA 02115 USA.;Southern Univ Coll, Skudai, Malaysia..
    Kissela, Brett M.
    Univ Cincinnati, Cincinnati, OH USA..
    Kissoon, Niranjan
    Univ British Columbia, Vancouver, BC, Canada..
    Knibbs, Luke D.
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Knudsen, Ann Kristin
    Ctr Dis Burden, Oslo, Norway.;Dept Global Publ Hlth & Primary Care, Jimma, Ethiopia..
    Kokubo, Yoshihiro
    Natl Cerebral Cardiovasc Ctr, Dept Prevent Cardiol, Suita, Osaka, Japan..
    Kolte, Dhaval
    Brown Univ, Div Cardiol, Providence, RI 02912 USA..
    Kopec, Jacek A.
    Univ British Columbia, Vancouver, BC, Canada..
    Kosen, Soewarta
    NIHRD, Ctr Community Empowerment, Hlth Policy & Human, Jakarta, Indonesia..
    Koul, Parvaiz A.
    Sher Kashmir Inst Med Sci, Srinagar, Jammu & Kashmir, India..
    Koyanagi, Ai
    Parc Sanitari Sant Joan Deu CIBERSAM, Res & Dev Unit, Barcelona, Spain..
    Krog, Norun Hjertager
    Norwegian Inst Publ Hlth, Oslo, Norway.;Norwegian Inst Publ Hlth, Oslo, Norway..
    Defo, Barthelemy Kuate
    Univ Montreal, Dept Demog & Publ Hlth, Res Inst, Montreal, PQ, Canada.;Univ Montreal, Dept Social & Prevent Med, Sch Publ Hlth, Montreal, PQ, Canada..
    Bicer, Burcu Kucuk
    Hacettepe Univ, Inst Publ Hlth, Ankara, Turkey..
    Kudom, Andreas A.
    Univ Cape Coast, Cape Coast, Ghana..
    Kuipers, Ernst J.
    Dept Hlth, Manila, Philippines.;Univ Med Ctr Rotterdam, Erasmus MC, Rotterdam, Netherlands..
    Kulkarni, Veena S.
    Arkansas State Univ, State Univ, AR USA..
    Kumar, G. Anil
    Publ Hlth Fdn India, New Delhi, India..
    Kwan, Gene F.
    Boston Univ, Sch Med, Boston, MA USA..
    Lal, Aparna
    Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia..
    Lal, Dharmesh Kumar
    Publ Hlth Fdn India, Gurgaon, India..
    Lalloo, Ratilal
    Univ Queensland, Sch Dent, Brisbane, Qld, Australia..
    Lam, Hilton
    Natl Inst Hlth, Inst Hlth Policy & Dev Studies, Manila, Philippines..
    Lam, Jennifer O.
    Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA..
    Langan, Sinead M.
    London Sch Hyg & Trop Med, London, England..
    Lansingh, Van C.
    Help Me See Inc, New York, NY USA.;Inst Mexicano Oftalmol, Queretaro, Mexico..
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Laryea, Dennis Odai
    Komfo Anokye Teaching Hosp, Kumasi, Ghana..
    Latif, Asma Abdul
    WomenUniv, Lahore Coll, Dept Zool, Lahore, Pakistan..
    Lawrynowicz, Alicia Elena Beatriz
    Inst Nacl Epidemiol Dr Juan H Jara, Mar Del Plata, Argentina..
    Leigh, James
    Univ Sydney, Sydney, NSW, Australia..
    Levi, Miriam
    Tuscany Reg Ctr Occupat Injuries & Dis, Florence, Italy..
    Li, Yongmei
    Lindsay, M. Patrice
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada.;Heart & Stroke Fdn Canada, Ottawa, ON, Canada..
    Lipshultz, Steven E.
    Wayne State Univ, Sch Med, Detroit, MI USA.;Childrens Hosp Michigan, Detroit, MI USA..
    Liu, Patrick Y.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Liu, Shiwei
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Liu, Yang
    San Francisco VA Med Ctr, San Francisco, CA USA.;Emory Univ, Atlanta, GA 30322 USA..
    Lo, Loon-Tzian
    UnionHlth Associates LLC, St Louis, MO USA.;Alton Mental Hlth Ctr, Alton, IL USA..
    Logroscino, Giancarlo
    Univ Bari, Bari, Italy..
    Lotufo, Paulo A.
    Univ Sao Paulo, Sao Paulo, Brazil..
    Lucas, Robyn M.
    Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia..
    Lunevicius, Raimundas
    Aintree Univ Hosp Natl Hlth Serv Fdn Trust, Liverpool, Merseyside, England.;Univ Liverpool, Sch Med, Liverpool, Merseyside, England..
    Lyons, Ronan A.
    Farr Inst, Swansea, W Glam, Wales..
    Ma, Stefan
    Minist Hlth Singapore, Singapore, Singapore.;Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore..
    Pedro Machado, Vasco Manuel
    Dept Publ Hlth, No Region Hlth Adm, Oporto, Portugal..
    Mackay, Mark T.
    Royal Childrens Hosp, Melbourne, Vic, Australia..
    MacLachlan, Jennifer H.
    Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia..
    Abd El Razek, Hassan Magdy
    Mansoura Fac Med, Mansoura, Egypt..
    Abd El Razek, Mohammed Magdy
    Aswan Univ Hosp, Aswan Fac Med, Aswan, Egypt..
    Majdan, Marek
    Trnava Univ, Dept Publ Hlth, Fac Hlth Sci & Social Work, Trnava, Slovakia..
    Majeed, Azeem
    Imperial Coll London, London, England..
    Malekzadeh, Reza
    Univ Tehran Med Sci, Digest Dis Res Inst, Tehran, Iran..
    Ayele Manamo, Wondimu Ayele
    Univ Addis Ababa, Addis Ababa, Ethiopia..
    Mandisarisa, John
    JSI Res & Training, Harare, Zimbabwe..
    Mangalam, Srikanth
    Tech Stand & Safety Author, Toronto, ON, Canada..
    Mapoma, Chabila C.
    Univ Zambia, Lusaka, Zambia..
    Marcenes, Wagner
    Kings Coll London, Div Populat & Patient Hlth, Inst Dent, London, England..
    Margolis, David Joel
    Univ Penn, Philadelphia, PA USA..
    Martin, Gerard Robert
    Childrens Natl Hlth Syst, Washington, DC USA..
    Martinez-Raga, Jose
    Univ Valencia, Univ Hosp Doctor Peset, Valencia, Spain.;CEU Cardenal Herrera Univ, Valencia, Spain..
    Marzan, Melvin Barrientos
    Univ E Ramon Magsaysay Mem Med Ctr, Quezon City, Philippines..
    Masiye, Felix
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Zambia, Lusaka, Zambia..
    Mason-Jones, Amanda J.
    Univ York, Dept Hlth Sci, York, N Yorkshire, England..
    Massano, Joao
    Univ Porto, Fac Med, Oporto, Portugal.;ULS Matosinhos, Hosp Pedro Hispano, Matosinhos, Portugal..
    Matzopoulos, Richard
    South African Med Res Council, Cape Town, South Africa.;Univ Cape Town, Sch Publ Hlth & Family Med, Cape Town, South Africa..
    Mayosi, Bongani M.
    Univ Cape Town, Cape Town, South Africa..
    McGarvey, Stephen Theodore
    Brown Univ, Providence, RI 02912 USA..
    McGrath, John J.
    Univ Queensland, Brisbane, Qld, Australia..
    Mckee, Martin
    London Sch Hyg & Trop Med, London, England..
    McMahon, Brian J.
    Alaska Native Tribal Hlth Consortium, Anchorage, AK USA..
    Meaney, Peter A.
    Univ Penn, Perelman Sch Med, Philadelphia, PA USA.;Childrens Hosp Philadelphia, Philadelphia, PA USA..
    Mehari, Alem
    Howard Univ, Coll Med, Washington, DC 20059 USA..
    Mehndiratta, Man Mohan
    Janakpuri Superspecialty Hosp, New Delhi, India..
    Mena-Rodriguez, Fabiola
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Mekonnen, Alemayehu B.
    Univ Sydney, Sydney, NSW, Australia.;Univ Gondar, Gondar, Ethiopia..
    Melaku, Yohannes Adama
    Sch Publ Hlth, Mekelle, Ethiopia.;Sch Med, Adelaide, SA, Australia..
    Memiah, Peter
    Univ Florida, Pensacola, FL USA..
    Memish, Ziad A.
    Saudi Minist Hlth, Riyadh, Saudi Arabia.;Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia..
    Mendoza, Walter
    United Nations Populat Fund, Lima, Peru..
    Meretoja, Atte
    Dept Med, Melbourne, Vic, Australia.;Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland..
    Meretoja, Tuomo J.
    Helsinki Univ Hosp, Breast Surg Unit, Ctr Comprehens Canc, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland..
    Mhimbira, Francis Apolinary
    Ifakara Hlth Inst, Bagamoyo, Tanzania..
    Micha, Renata
    Friedman Sch Nutr Sci & Policy, Boston, MA USA..
    Miller, Ted R.
    Pacific Inst Res Evaluat, Calverton, MD USA.;Curtin Univ, Ctr Populat Hlth, Perth, WA, Australia..
    Mirarefin, Mojde
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Misganaw, Awoke
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Mock, Charles N.
    Harborview Injury Prevent & Res Ctr, Seattle, WA USA..
    Abdulmuhsin Mohammad, Karzan
    Univ Salahaddin, Erbil, Iraq..
    Mohammadi, Alireza
    Baqiyatallah Univ Med Sci, Neurosci Res Ctr, Tehran, Iran..
    Mohammed, Shafiu
    Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany.;Ahmadu Bello Univ, Hlth Syst & Policy Res Unit, Zaria, Nigeria..
    Mohan, Viswanathan
    Madras Diabet Res Fdn, Chennai, Tamil Nadu, India.;Dr Mohans Diabet Special Ctr, Chennai, Tamil Nadu, India..
    Mola, Glen Liddell D.
    Univ Papua New Guinea, Boroko, Papua N Guinea..
    Monasta, Lorenzo
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy..
    Montanez Hernandez, Julio Cesar
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Montero, Pablo
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Montico, Marcella
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy..
    Montine, Thomas J.
    Univ Washington, Seattle, WA 98195 USA..
    Moradi-Lakeh, Maziar
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Iran Univ Med Sci, Prevent Med & Publ Hlth Res Ctr, Gastrointestinal & Liver Dis Res Ctr, Dept Community Med, Brisbane, Qld, Australia..
    Morawska, Lidia
    Queensland Univ Technol, Int Lab Air Qual & Hlth, Brisbane, Qld, Australia..
    Morgan, Katherine
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Mori, Rintaro
    Natl Ctr Child Hlth & Dev, Tokyo, Japan..
    Mozaffarian, Dariush
    Friedman Sch Nutr Sci & Policy, Boston, MA USA..
    Mueller, Ulrich
    Fed Inst Populat Res, Wiesbaden, Germany..
    Satyanarayana Murthy, Gudlavalleti Venkata
    London Sch Hyg & Trop Med, London, England.;Indian Inst Publ Hlth, Gurgaon, India..
    Murthy, Srinivas
    Univ British Columbia, Vancouver, BC, Canada..
    Musa, Kamarul Imran
    Univ Sci Malaysia, Sch Med Sci, Kubang Kerian, Malaysia..
    Nachega, Jean B.
    Bloomberg Sch Publ Hlth, Baltimore, MD USA.;Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA.;Univ Stellenbosch, Cape Town, South Africa..
    Nagel, Gabriele
    Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany..
    Naidoo, Kovin S.
    Univ KwaZulu Natal, Durban, South Africa..
    Naik, Nitish
    All India Inst Med Sci, New Delhi, India..
    Naldi, Luigi
    Azienda Osped Papa Giovanni XXIII, Bergamo, Italy..
    Nangia, Vinay
    Suraj Eye Inst, Nagpur, Maharashtra, India..
    Nash, Denis
    CUNY, Inst Implementat Sci Populat Hlth, Sch Publ Hlth, New York, NY USA..
    Nejjari, Chakib
    Fac Med, Fes, Morocco..
    Neupane, Subas
    Univ Tampere, Sch Hlth Sci, Tampere, Finland..
    Newton, Charles R.
    KEMRI Wellcome Trust, Kilifi, Kenya..
    Newton, John N.
    Publ Hlth England, London, England..
    Ng, Marie
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Ngalesoni, Frida Namnyak
    Minist Hlth & Social Welf, Dar Es Salaam, Tanzania..
    Ngirabega, Jean de Dieu
    East African Community Hlth Res Commiss, Kigali, Rwanda..
    Nguyen, Quyen Le
    Nisar, Muhammad Imran
    Aga Khan Univ, Karachi, Pakistan..
    Nkamedjie Pete, Patrick Martial
    Inst Res Socioecon Dev & Commun, Yaounde, Cameroon..
    Nomura, Marika
    Natl Inst Publ Hlth, Saitama, Japan..
    Norheim, Ole F.
    Univ Bergen, Bergen, Norway..
    Norman, Paul E.
    Univ Western Australia, Fremantle, WA, Australia..
    Norrving, Bo
    Lund Univ, Dept Clin Sci Lund, Skane Univ Hosp, Lund, Sweden..
    Nyakarahuka, Luke
    Makerere Univ, Kampala, Uganda..
    Ogbo, Felix Akpojene
    Univ Western Sydney, Ctr Hlth Res, Sydney, NSW, Australia..
    Ohkubo, Takayoshi
    Teikyo Univ, Sch Med, Tokyo, Japan..
    Ojelabi, Foluke Adetola
    Univ Ibadan, Ibadan, Nigeria..
    Olivares, Pedro R.
    Univ Autonoma Chile, Talca, Chile..
    Olusanya, Bolajoko Olubukunola
    Ctr Healthy Start Initiat, Lagos, Nigeria..
    Olusanya, Jacob Olusegun
    Ctr Healthy Start Initiat, Lagos, Nigeria..
    Opio, John Nelson
    Lira Municipal Council, Lira Dist Local Govt, Lira, Uganda..
    Oren, Eyal
    Univ Arizona, Tucson, AZ USA..
    Ortiz, Alberto
    IIS Fdn Jimenez Diaz UAM, Madrid, Spain..
    Osman, Majdi
    Harvard Med Sch, Boston, MA USA.;YBank, Cambridge, MA USA..
    Ota, Erika
    St Lukes Int Univ, Tokyo, Japan..
    Ozdemir, Raziye
    St Lukes Int Univ, Tokyo, Japan.;Karabuk Univ, Karabuk, Turkey..
    Pa, Mahesh
    JSS Univ, JSS Med Coll, Mysore, Karnataka, India..
    Pandian, Jeyaraj D.
    Christian Med Coll Ludhiana, Ludhiana, Punjab, India..
    Pant, Puspa Raj
    Univ W England, Bristol, Avon, England..
    Papachristou, Christina
    Charite Univ Med Berlin, Berlin, Germany..
    Park, Eun-Kee
    Kosin Univ, Dept Med Human & Social Med, Coll Med, Busan, South Korea..
    Park, Jae-Hyun
    Sungkyunkwan Univ, Samsung Biomed Res Inst, Sch Med, Dept Social & Prevent Med, Suwon, South Korea..
    Parry, Charles D.
    Alcohol Tobacco & Other Drug Res Unit, Cape Town, South Africa.;Univ Stellenbosch, Dept Psychiat, Cape Town, South Africa.;Alcohol, Tobacco Other Drug Res Unit, Potchefstroom, South Africa..
    Parsaeian, Mahboubeh
    Univ Tehran Med Sci, Non Communicable Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.;Univ Tehran Med Sci, Dept Epidemiol & Biostat, Sch Publ Hlth, Tehran, Iran..
    Caicedo, Angel J. Paternina
    Univ Pittsburgh, Publ Hlth Dynam Lab, Pittsburgh, PA USA.;Univ Cartagena, Cartagena, Colombia..
    Patten, Scott B.
    Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada..
    Patton, George C.
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia..
    Paul, Vinod K.
    All India Inst Med Sci, New Delhi, India..
    Pearce, Neil
    London Sch Hyg & Trop Med, London, England..
    Pedro, Joao Mario
    Univ Porto, EPIUnit, Oporto, Portugal.;Hlth Res Ctr Angola, Caxito, Angola..
    Stokic, Ljiljana Pejin
    Inst Econ, Belgrade, Serbia..
    Pereira, David M.
    Univ Porto, Fac Farm, Dept Quim, Lab Farm,REQUIMTE LAQV, Oporto, Portugal..
    Perico, Norberto
    IRCCS Ist Ric Farmacol Mario Negri, Bergamo, Italy..
    Pesudovs, Konrad
    Flinders Univ S Australia, Adelaide, SA, Australia..
    Petzold, Max
    Univ Gothenburg, Hlth Metr Unit, Gothenburg, Sweden.;Univ Witwatersrand, Johannesburg, South Africa..
    Phillips, Michael Robert
    Emory Univ, Atlanta, GA 30322 USA.;Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China..
    Piel, Frederic B.
    Imperial Coll London, Dept Epidemiol & Biostat, London, England..
    Pillay, Julian David
    Durban Univ Technol, Durban, South Africa..
    Plass, Dietrich
    German Environm Agcy, Exposure Assessment & Environm Hlth Indicators, Berlin, Germany..
    Platts-Mills, James A.
    Univ Virginia, Charlottesville, VA USA..
    Polinder, Suzanne
    Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands..
    Pope, C. Arden
    Brigham Young Univ, Provo, UT USA..
    Popova, Svetlana
    Ctr Addict & Mental Hlth, Toronto, ON, Canada..
    Poulton, Richie G.
    Univ Otago, Dunedin, New Zealand..
    Pourmalek, Farshad
    Univ British Columbia, Vancouver, BC, Canada..
    Prabhakaran, Dorairaj
    Ctr Chron Dis Control, New Delhi, India..
    Qorbani, Mostafa
    Alborz Univ Med Sci, Sch Med, Dept Community Med, Karaj, Iran..
    Quame-Amaglo, Justice
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Quistberg, D. Alex
    Harborview Injury Prevent & Res Ctr, Seattle, WA USA.;Dept Anesthesiol & Pain Med, Seattle, WA USA..
    Rafay, Anwar
    Sch Publ Hlth, Lahore, Pakistan..
    Rahimi, Kazem
    Univ Oxford, Oxford, England..
    Rahimi-Movaghar, Vafa
    Univ Tehran Med Sci, Sina Trauma & Surg Res Ctr, Tehran, Iran..
    Rahman, Mahfuzar
    Res & Evaluat Div, BRAC, Dhaka, Bangladesh.;Hamad Med Corp, Doha, Qatar..
    Rahman, Mohammad Hifz Ur
    Int Inst Populat Sci, Mumbai, Maharashtra, India..
    Rahman, Sajjad Ur
    Rai, Rajesh Kumar
    Soc Hlth & Demog Surveillance, Suri, India..
    Rajavi, Zhale
    Shahid Beheshti Univ Med Sci, Ophthalm Res Ctr, Tehran, Iran..
    Rajsic, Sasa
    UMIT, ERAWEB Program, Hall, Tyrol, Austria..
    Raju, Murugesan
    Univ Missouri, Columbia, MO USA..
    Rakovac, Ivo
    WHO Reg Off Europe, Copenhagen, Denmark..
    Rana, Saleem M.
    Sch Publ Hlth, Lahore, Pakistan.;Contech Int Hlth Consultants, Lahore, Pakistan..
    Ranabhat, Chhabi L.
    Yonsei Univ, Wonju Coll Med, Inst Poverty Alleviat & Int Dev, Wonju, South Korea..
    Rangaswamy, Thara
    Schizophrenia Res Fdn, Chennai, Tamil Nadu, India..
    Rao, Puja
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Rao, Sowmya R.
    Boston Univ, Dept Surg, Sch Med, Boston, MA USA..
    Refaat, Amany H.
    Walden Univ, Minneapolis, MN USA.;Suez Canal Univ, Ismailia, Egypt..
    Rehm, Jurgen
    Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.;Ctr Addict & Mental Hlth, Toronto, ON, Canada..
    Reitsma, Marissa B.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Remuzzi, Giuseppe
    Azienda Osped Papa Giovanni XXIII, Bergamo, Italy.;IRCCS Ist Ric Farmacol Mario Negri, Bergamo, Italy.;Univ Milan, Dept Biomed & Clin Sci L Sacco, Milan, Italy..
    Resnikofff, Serge
    Brien Holden Vis Inst, Sydney, NSW, Australia.;Sch Optometry & Vis Sci, Sydney, NSW, Australia..
    Ribeiro, Antonio L.
    Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil..
    Ricci, Stefano
    UO Neurol USL Umbria 1, Castello, Italy..
    Blancas, Maria Jesus Rios
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Roberts, Bayard
    London Sch Hyg & Trop Med, London, England..
    Roca, Anna
    The Gambia, Med Res Council Unit, Fajara, Gambia..
    Rojas-Rueda, David
    I SGlobal, Barcelona, Spain. Golestan Univ Med Sci, Gorgan, Iran..
    Ronfani, Luca
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy..
    Roshandel, Gholamreza
    Univ Tehran Med Sci, Digest Dis Res Inst, Tehran, Iran.;Golestan Univ Med Sci, Golestan Res Ctr Gastroenterol & Hepatol, Gorgan, Iran..
    Rothenbacher, Dietrich
    Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany..
    Roy, Ambuj
    All India Inst Med Sci, New Delhi, India..
    Roy, Nawal K.
    Holmusk, Singapore, Singapore.;Duke NUS Med Sch, Singapore, Singapore..
    Ruhago, George Mugambage
    Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania..
    Sagar, Rajesh
    All India Inst Med Sci, New Delhi, India..
    Saha, Sukanta
    Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Brisbane, Qld, Australia..
    Sahathevan, Ramesh
    Ballarat Hlth Serv, Ballarat, Vic, Australia.;Univ Kebangsaan Malaysia, Med Ctr, Kuala Lumpur, Malaysia..
    Saleh, Muhammad Muhammad
    Dev Res & Projects Ctr, Abuja, Nigeria..
    Sanabria, Juan R.
    Marshall Univ, Edwards Sch Med J, Huntington, WV USA.;Case Western Reserve Univ, Cleveland, OH 44106 USA..
    Sanchez-Nino, Maria Dolores
    IIS Fdn Jimenez Diaz, Madrid, Spain..
    Sanchez-Riera, Lidia
    LHosp, Inst Invest Biomed Bellvitge IDIBELL, Lhospitalet De Llobregat, Spain..
    Santos, Itamar S.
    Univ Sao Paulo, Dept Internal Med, Sao Paulo, Brazil..
    Sarmiento-Suarez, Rodrigo
    Univ Ciencias Aplicadas & Ambient, Bogota, Colombia..
    Sartorius, Benn
    Univ KwaZulu Natal, Durban, South Africa..
    Satpathy, Maheswar
    All India Inst Med Sci, New Delhi, India..
    Savic, Miloje
    Norwegian Inst Publ Hlth, Oslo, Norway.;Norwegian Inst Publ Hlth, Oslo, Norway..
    Sawhney, Monika
    Marshall Univ, Huntington, WV USA..
    Schaub, Michael P.
    Swiss Res Inst Publ Hlth & Addict, Zurich, Switzerland..
    Schmidt, Maria Ines
    Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil..
    Schneider, Ione J. C.
    Univ Fed Santa Catarina, Florianopolis, SC, Brazil..
    Schottker, Ben
    German Canc Res Ctr, Heidelberg, Germany.;FOM Univ, Inst Hlth Care & Social Sci, Essen, Germany..
    Schutte, Aletta E.
    Northwest Univ, Hypertens Africa Res Team HART, Potchefstroom, South Africa.;South African Med Res Council, Potchefstroom, South Africa..
    Schwebel, David C.
    Univ Alabama Birmingham, Birmingham, AL USA..
    Seedat, Soraya
    Univ Stellenbosch, Cape Town, South Africa..
    Sepanlou, Sadaf G.
    Univ Tehran Med Sci, Digest Dis Res Inst, Tehran, Iran..
    Servan-Mori, Edson E.
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Shackelford, Katya A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Shaddick, Gavin
    Univ Bath, Bath, Avon, England..
    Shaheen, Amira
    Najah Univ, Dept Publ Hlth, Nablus, Israel..
    Shahraz, Saeid
    Tufts Med Ctr, Boston, MA USA..
    Shaikh, Masood Ali
    Independent Consultant, Karachi, Pakistan..
    Shakh-Nazarova, Marina
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Sharma, Rajesh
    Indian Inst Technol Ropar, Rupnagar, India..
    She, Jun
    Zhongshan Hosp, Lucknow, Uttar Pradesh, India..
    Sheikhbahaei, Sara
    Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Tehran, Iran..
    Shen, Jiabin
    Ohio State Univ, Coll Med, Columbus, OH 43210 USA.;Nationwide Childrens Hosp, Res Inst, Columbus, OH USA..
    Shen, Ziyan
    Zhongshan Hosp, Dept Nephrol, Lucknow, Uttar Pradesh, India.;Shanghai Kidney & Dialysis Inst, Shanghai, Peoples R China..
    Shepard, Donald S.
    Brandeis Univ, Waltham, MA USA..
    Sheth, Kevin N.
    Yale Univ, Sch Med, New Haven, CT USA..
    Shetty, Balakrishna P.
    Sri Siddhartha Univ, Tumkur, India.;ISHA Diagnost, Bangalore, Karnataka, India..
    Shi, Peilin
    Tufts Univ, Boston, MA 02111 USA..
    Shibuya, Kenji
    Univ Tokyo, Tokyo, Japan..
    Shin, Min-Jeong
    Korea Univ, Grad Sch, Dept Publ Hlth Sci, Seoul, South Korea..
    Shiri, Rahman
    Finnish Inst Occupat Hlth, Work Org, Work Disabil Prevent, Helsinki, Finland..
    Shiue, Ivy
    Alzheimer Scotland Dementia Res Ctr, Edinburgh, Midlothian, Scotland.;Northumbria Univ, Fac Hlth & Life Sci, Newcastle Upon Tyne, Tyne & Wear, England..
    Shrime, Mark G.
    Harvard Med Sch, Boston, MA USA..
    Sigfusdottir, Inga Dora
    Reykjavik Univ, Reykjavik, Iceland..
    Silberberg, Donald H.
    Univ Penn, Philadelphia, PA USA..
    Silva, Diego Augusto Santos
    Univ Fed Santa Catarina, Florianopolis, SC, Brazil..
    Silveira, Dayane Gabriele Alves
    Univ Brasilia, Brasilia, DF, Brazil..
    Silverberg, Jonathan I.
    Feinberg Sch Med, Chicago, IL USA..
    Simard, Edgar P.
    Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA..
    Singh, Abhishek
    Int Inst Populat Sci, Mumbai, Maharashtra, India..
    Singh, Gitanjali M.
    Tufts Univ, Boston, MA 02111 USA..
    Singh, Jasvinder A.
    Univ Alabama Birmingham, Birmingham, AL USA..
    Singh, Om Prakash
    Banaras Hindu Univ, Inst Med Sci, Dept Med, Varanasi, Uttar Pradesh, India..
    Singh, Prashant Kumar
    Inst Human Dev, New Delhi, India..
    Singh, Virendra
    Asthma Bhawan, Jaipur, Rajasthan, India..
    Soneji, Samir
    Dartmouth Coll, Hanover, NH USA..
    Soreide, Kjetil
    Stavanger Univ Hosp, Stavanger, Norway..
    Soriano, Joan B.
    Univ Autonoma Madrid, Inst Invest Hosp Univ Princesa, Madrid, Spain..
    Sposato, Luciano A.
    Western Univ, Dept Clin Neurol Sci, London, ON, Canada..
    Sreeramareddy, Chandrashekhar T.
    Int Med Univ, Dept Community Med, Kuala Lumpur, Malaysia..
    Stathopoulou, Vasiliki
    Attikon Univ Hosp, Athens, Greece..
    Stein, Dan J.
    Univ Cape Town, Dept Psychiat, Cape Town, South Africa.;South African Med Res Council, Unit Anxiety & Stress Disorders, Cape Town, South Africa..
    Stein, Murray B.
    Univ Calif San Diego, San Diego, CA 92103 USA..
    Stranges, Saverio
    Luxembourg Inst Hlth, Luxembourg, Luxembourg..
    Stroumpoulis, Konstantinos
    Alexandra Gen Hosp Athens, Athens, Greece.;Ctr Hosp Publ Cotentin, Cherbourg, France..
    Sunguya, Bruno F.
    Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania..
    Sur, Patrick
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Swaminathan, Soumya
    Indian Council Med Res, New Delhi, India..
    Sykes, Bryan L.
    Univ Calif Irvine, Dept Criminol, Irvine, CA USA.;Univ Calif Irvine, Law & Soc Sociol & Publ Hlth, Irvine, CA USA.;Univ Calif Irvine, Irvine, CA USA..
    Szoeke, Cassandra E. I.
    Inst Hlth & Ageing, Melbourne, Vic, Australia..
    Tabares-Seisdedos, Rafael
    Univ Valencia, Dept Med, INCLIVA Hlth Res Inst & CIBERSAM, Valencia, Spain..
    Tabb, Karen M.
    Univ Illinois, Sch Social Work, Urbana, IL USA..
    Takahashi, Ken
    Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Environm Epidemiol, Kitakyushu, Fukuoka, Japan..
    Takala, Jukka S.
    WSH Inst, Minist Manpower, Singapore, Singapore.;Tampere Univ Technol, Tampere, Finland..
    Talongwa, Roberto Tchio
    Minist Hlth, MINSANTE, Yaounde, Cameroon..
    Tandon, Nikhil
    All India Inst Med Sci, New Delhi, India..
    Tavakkoli, Mohammad
    New York Med Coll, Valhalla, NY USA..
    Taye, Bineyam
    Colgate Univ, Dept Biol, Hamilton, NY USA..
    Taylor, Hugh R.
    Univ Melbourne, Melbourne, Vic, Australia..
    Ao, Braden J. Te
    Auckland Univ Technol, Auckland, New Zealand..
    Tedla, Bemnet Amare
    Univ Gondar, Gondar, Ethiopia.;James Cook Univ, Cairns, Qld, Australia..
    Tefera, Worku Mekonnen
    Univ Addis Ababa, Addis Ababa, Ethiopia.;Addis Ababa City Govt, Addis Ababa, Ethiopia..
    Ten Have, Margreet
    Netherlands Inst Mental Hlth & Addict, Utrecht, Netherlands..
    Terkawi, Abdullah Sulieman
    King Fahad Med City, Dept Anesthesiol, Riyadh, Saudi Arabia.;Univ Virginia, Dept Anesthesiol, Charlottesville, VA USA.;Outcomes Res Consortium, Cleveland, OH USA..
    Tesfay, Fisaha Haile
    Coll Hlth Sci, Mekelle, Ethiopia.;Flinders Univ S Australia, Adelaide, SA, Australia..
    Tessema, Gizachew Assefa
    Univ Adelaide, Adelaide, SA, Australia.;Univ Gondar, Gondar, Ethiopia..
    Thomson, Alan J.
    Adapt Knowledge Management, Victoria, BC, Canada..
    Thorne-Lyman, Andrew L.
    WorldFish, George Town, Malaysia..
    Thrift, Amanda G.
    Monash Univ, Sch Clin Sci Monash Hlth, Dept Med, Melbourne, Vic, Australia..
    Thurston, George D.
    New York Univ, Nelson Inst Environm Med, Sch Med, Tuxedo Pk, NY USA..
    Tillmann, Taavi
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Tirschwell, David L.
    Univ Washington, Seattle, WA 98195 USA..
    Tonelli, Marcello
    Univ Calgary, Calgary, AB, Canada..
    Topor-Madry, Roman
    Jagiellonian Univ Med Coll, Inst Publ Hlth, Fac Hlth Sci, Krakow, Poland.;Wroclaw Med Univ, Fac Hlth Sci, Wroclaw, Poland..
    Topouzis, Fotis
    Aristotle Univ Thessaloniki, Thessaloniki, Greece..
    Nx, Jeffrey Allen Towb
    Bonheur Childrens Hosp Memphis, Memphis, TN USA.;Univ Tennessee Hlth Sci Ctr, Memphis, TN USA.;St Jude Childrens Res Hosp, Memphis, TN USA..
    Traebert, Jefferson
    Univ Southern Santa Catarina, Palhoca, Brazil..
    Tran, Bach Xuan
    Johns Hopkins Univ, Baltimore, MD USA.;Hanoi Med Univ, Hanoi, Vietnam..
    Truelsen, Thomas
    Univ Copenhagen, Dept Neurol, Rigshosp, Copenhagen, Denmark..
    Trujillo, Ulises
    Serv Canario Salud, Santa Cruz de La Palma, CA, Spain..
    Tura, Abera Kenay
    Univ Med Ctr Groningen, Groningen, Netherlands.;Haramaya Univ, Dire Dawa, Ethiopia..
    Tuzcu, Emin Murat
    Cleveland Clin, Cleveland, OH USA..
    Uchendu, Uche S.
    Dept Vet Affairs, Washington, DC USA..
    Ukwaja, Kingsley N.
    Fed Teaching Hosp, Dept Internal Med, Abakaliki, Nigeria..
    Undurraga, Eduardo A.
    Brandeis Univ, Waltham, MA USA..
    Uthman, Olalekan A.
    Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England..
    Van Dingenen, Rita
    Joint Res Ctr, European Commiss, Ispra, Italy..
    Van Donkelaar, Aaron
    Univ Oxford, Oxford, England.;Dalhousie Univ, Dept Phys & Atsmopher Sci, Halifax, NS, Canada..
    Vasankari, Tommi
    Vasconcelos, Ana Maria Nogales
    UKK Inst Hlth Promot Res, Tampere, Finland.;Univ Brasilia, Brasilia, DF, Brazil..
    Venketasubramanian, Narayanaswamy
    Raffles Hosp, Raffles Neurosci Ctr, Singapore, Singapore..
    Vidavalur, Ramesh
    Weill Cornell Med Coll, New York, NY USA..
    Vijayakumar, Lakshmi
    Ctr Youth Mental Hlth, Melbourne, Vic, Australia.;VHS SNEHA, Chennai, Tamil Nadu, India..
    Villalpando, Salvador
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Violante, Francesco S.
    Univ Bologna, Bologna, Italy..
    Vlassov, Vasiliy Victorovich
    Natl Res Univ, Higher Sch Econ, Moscow, Russia..
    Wagner, Joseph A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Wagner, Gregory R.
    Harvard T H Chan Sch Publ Hlth, Boston, MA USA.;Natl Inst Occupat Safety & Hlth, Washington, DC USA..
    Wallin, Mitchell T.
    VA Med Ctr, Washington, DC USA.;Georgetown Univ, Dept Neurol, Washington, DC USA..
    Wang, Linhong
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Watkins, David A.
    Univ Washington, Seattle, WA 98195 USA.;Univ Cape Town, Cape Town, South Africa..
    Weichenthal, Scott
    McGill Univ, Montreal, PQ, Canada..
    Weiderpass, Elisabete
    Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Canc Registry Norway, Inst Populat Based Canc Res, Dept Res, Oslo, Norway.;Univ Tromso, Arctic Univ Norway, Dept Community Med, Fac Hlth Sci, Tromso, Norway.;Genet Epidemiol Grp, Folkhalsan Res Ctr, Helsinki, Finland..
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    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.;Royal Childrens Hosp, Melbourne, Vic, Australia..
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    Competence Ctr Mortal Follow Up German Natl Cohor, Wiesbaden, Germany..
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    Fed Inst Populat Res, Wiesbaden, Germany.;German Natl Cohort Consortium, Heidelberg, Germany..
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    Norwegian Inst Publ Hlth, Dept Infect Dis Epidemiol & Modelling, Oslo, Norway..
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    Univ Melbourne, Melbourne, Vic, Australia.;Western Hlth, Footscray, Vic, Australia..
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    Wayne State Univ, Sch Med, Detroit, MI USA.;Childrens Hosp Michigan, Detroit, MI 48201 USA..
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    Div Hlth & Social Care Res, London, England.;Guys & St Thomas NHS Fdn Trust & Kings Coll, Natl Inst Hlth Res Comprehens Biomed Res Ctr, London, England..
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    Seoul Natl Univ, Grad Sch Publ Hlth, Seoul, South Korea..
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    Manila Univ, Ateneo Sch Med & Publ Hlth, Pasig, Philippines..
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    Royal Cornwall Hosp, Truro, England..
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    St Johns Med Coll & Res Inst, Bangalore, Karnataka, India..
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    Emory Univ, Atlanta, GA 30322 USA..
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    Nanjing Univ, Sch Med, Dept Neurol, Jinling Hosp, Nanjing, Jiangsu, Peoples R China..
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    Univ KwaZulu Natal, Sch Nursing & Publ Hlth, Discipline Publ Hlth Med, Durban, South Africa..
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    Mekelle Univ, Mekelle, Ethiopia..
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    Duke Kunshan Univ, Global Hlth Res Ctr, Kunshan, Peoples R China..
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    Northwestern Univ, Dept Prevent Med, Chicago, IL USA..
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    Shahid Beheshti Univ Med Sci, Ophthalm Res Ctr, Tehran, Iran..
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    Yebyo, Henock Gebremedhin
    Mekelle Univ, Mekelle, Ethiopia.;Univ Zurich, Zurich, Switzerland..
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    Social Work & Social Adm Dept, Hong Kong, Hong Kong, Peoples R China.;Univ Hong Kong, Hong Kong Jockey Club Ctr Suicide Res & Prevent, Hong Kong, Hong Kong, Peoples R China..
    Yirsaw, Biruck Desalegn
    Univ Addis Ababa, Addis Ababa, Ethiopia.;Univ South Australia, Mawson Lakes, SA, Australia..
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    Kyoto Univ, Sch Publ Hlth, Dept Biostatist, Kyoto, Japan..
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    Aga Khan Univ, Nairobi, Kenya..
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    Jackson State Univ, Jackson, MS USA..
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    Chinese Ctr Dis Control, Beijing, Peoples R China..
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    Univ Hosp, Setif, Algeria..
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    Mansoura Univ, Fac Med, Mansoura, Egypt..
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    Univ Lorraine, Clin Invest Ctr, INSERM, Natl Inst Hlth & Med Res, Vandoeuvre Ies Nancy, France.;CHU Nancy, Vandoeuvre Les Nancy, France..
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    Ponce Hlth Sci Univ, Ponce, PR USA..
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    Univ Gondar, Gondar, Ethiopia.;Monash Univ, Melbourne, Vic, Australia..
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    Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 20152016In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 388, no 10053, p. 1459-1544Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures.

    METHODS: We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010. Improvements included refinements to the estimation of child and adult mortality and corresponding uncertainty, parameter selection for under-5 mortality synthesis by spatiotemporal Gaussian process regression, and sibling history data processing. We also expanded the database of vital registration, survey, and census data to 14 294 geography-year datapoints. For GBD 2015, eight causes, including Ebola virus disease, were added to the previous GBD cause list for mortality. We used six modelling approaches to assess cause-specific mortality, with the Cause of Death Ensemble Model (CODEm) generating estimates for most causes. We used a series of novel analyses to systematically quantify the drivers of trends in mortality across geographies. First, we assessed observed and expected levels and trends of cause-specific mortality as they relate to the Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Second, we examined factors affecting total mortality patterns through a series of counterfactual scenarios, testing the magnitude by which population growth, population age structures, and epidemiological changes contributed to shifts in mortality. Finally, we attributed changes in life expectancy to changes in cause of death. We documented each step of the GBD 2015 estimation processes, as well as data sources, in accordance with Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER).

    FINDINGS: Globally, life expectancy from birth increased from 61·7 years (95% uncertainty interval 61·4-61·9) in 1980 to 71·8 years (71·5-72·2) in 2015. Several countries in sub-Saharan Africa had very large gains in life expectancy from 2005 to 2015, rebounding from an era of exceedingly high loss of life due to HIV/AIDS. At the same time, many geographies saw life expectancy stagnate or decline, particularly for men and in countries with rising mortality from war or interpersonal violence. From 2005 to 2015, male life expectancy in Syria dropped by 11·3 years (3·7-17·4), to 62·6 years (56·5-70·2). Total deaths increased by 4·1% (2·6-5·6) from 2005 to 2015, rising to 55·8 million (54·9 million to 56·6 million) in 2015, but age-standardised death rates fell by 17·0% (15·8-18·1) during this time, underscoring changes in population growth and shifts in global age structures. The result was similar for non-communicable diseases (NCDs), with total deaths from these causes increasing by 14·1% (12·6-16·0) to 39·8 million (39·2 million to 40·5 million) in 2015, whereas age-standardised rates decreased by 13·1% (11·9-14·3). Globally, this mortality pattern emerged for several NCDs, including several types of cancer, ischaemic heart disease, cirrhosis, and Alzheimer's disease and other dementias. By contrast, both total deaths and age-standardised death rates due to communicable, maternal, neonatal, and nutritional conditions significantly declined from 2005 to 2015, gains largely attributable to decreases in mortality rates due to HIV/AIDS (42·1%, 39·1-44·6), malaria (43·1%, 34·7-51·8), neonatal preterm birth complications (29·8%, 24·8-34·9), and maternal disorders (29·1%, 19·3-37·1). Progress was slower for several causes, such as lower respiratory infections and nutritional deficiencies, whereas deaths increased for others, including dengue and drug use disorders. Age-standardised death rates due to injuries significantly declined from 2005 to 2015, yet interpersonal violence and war claimed increasingly more lives in some regions, particularly in the Middle East. In 2015, rotaviral enteritis (rotavirus) was the leading cause of under-5 deaths due to diarrhoea (146 000 deaths, 118 000-183 000) and pneumococcal pneumonia was the leading cause of under-5 deaths due to lower respiratory infections (393 000 deaths, 228 000-532 000), although pathogen-specific mortality varied by region. Globally, the effects of population growth, ageing, and changes in age-standardised death rates substantially differed by cause. Our analyses on the expected associations between cause-specific mortality and SDI show the regular shifts in cause of death composition and population age structure with rising SDI. Country patterns of premature mortality (measured as years of life lost [YLLs]) and how they differ from the level expected on the basis of SDI alone revealed distinct but highly heterogeneous patterns by region and country or territory. Ischaemic heart disease, stroke, and diabetes were among the leading causes of YLLs in most regions, but in many cases, intraregional results sharply diverged for ratios of observed and expected YLLs based on SDI. Communicable, maternal, neonatal, and nutritional diseases caused the most YLLs throughout sub-Saharan Africa, with observed YLLs far exceeding expected YLLs for countries in which malaria or HIV/AIDS remained the leading causes of early death.

    INTERPRETATION: At the global scale, age-specific mortality has steadily improved over the past 35 years; this pattern of general progress continued in the past decade. Progress has been faster in most countries than expected on the basis of development measured by the SDI. Against this background of progress, some countries have seen falls in life expectancy, and age-standardised death rates for some causes are increasing. Despite progress in reducing age-standardised death rates, population growth and ageing mean that the number of deaths from most non-communicable causes are increasing in most countries, putting increased demands on health systems.

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    Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: the Global Burden of Disease Study 2015.2016In: The lancet. HIV, ISSN 2352-3018, Vol. 3, no 8, p. e361-e387Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015.

    METHODS: For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes. Our estimation strategy links the GBD 2015 assessment of all-cause mortality and estimation of incidence and prevalence so that for each draw from the uncertainty distribution all assumptions used in each step are internally consistent. We estimated incidence, prevalence, and death with GBD versions of the Estimation and Projection Package (EPP) and Spectrum software originally developed by the Joint United Nations Programme on HIV/AIDS (UNAIDS). We used an open-source version of EPP and recoded Spectrum for speed, and used updated assumptions from systematic reviews of the literature and GBD demographic data. For countries with high-quality vital registration data, we developed the cohort incidence bias adjustment model to estimate HIV incidence and prevalence largely from the number of deaths caused by HIV recorded in cause-of-death statistics. We corrected these statistics for garbage coding and HIV misclassification.

    FINDINGS: Global HIV incidence reached its peak in 1997, at 3·3 million new infections (95% uncertainty interval [UI] 3·1-3·4 million). Annual incidence has stayed relatively constant at about 2·6 million per year (range 2·5-2·8 million) since 2005, after a period of fast decline between 1997 and 2005. The number of people living with HIV/AIDS has been steadily increasing and reached 38·8 million (95% UI 37·6-40·4 million) in 2015. At the same time, HIV/AIDS mortality has been declining at a steady pace, from a peak of 1·8 million deaths (95% UI 1·7-1·9 million) in 2005, to 1·2 million deaths (1·1-1·3 million) in 2015. We recorded substantial heterogeneity in the levels and trends of HIV/AIDS across countries. Although many countries have experienced decreases in HIV/AIDS mortality and in annual new infections, other countries have had slowdowns or increases in rates of change in annual new infections.

    INTERPRETATION: Scale-up of ART and prevention of mother-to-child transmission has been one of the great successes of global health in the past two decades. However, in the past decade, progress in reducing new infections has been slow, development assistance for health devoted to HIV has stagnated, and resources for health in low-income countries have grown slowly. Achievement of the new ambitious goals for HIV enshrined in Sustainable Development Goal 3 and the 90-90-90 UNAIDS targets will be challenging, and will need continued efforts from governments and international agencies in the next 15 years to end AIDS by 2030.

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  • 463.
    Wang, Yunzhang
    et al.
    Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden.
    Karlsson, Robert
    Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden.
    Lampa, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Zhang, Qian
    Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
    Hedman, Åsa K
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.
    Almgren, Malin
    Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Stockholm, Sweden.
    Almqvist, Catarina
    Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden.
    McRae, Allan F.
    Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
    Marioni, Riccardo E.
    Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Dept Psychol, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.
    Ingelsson, Erik
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Stanford Univ, Sch Med, Div Cardiovasc Med, Dept Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
    Visscher, Peter M.
    Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia;Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia.
    Deary, Ian J.
    Univ Edinburgh, Dept Psychol, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Morris, Tiffany
    UCL, Canc Inst, London, England.
    Beck, Stephan
    UCL, Canc Inst, London, England.
    Pedersen, Nancy L.
    Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden.
    Hagg, Sara
    Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden.
    Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins2018In: Epigenetics, ISSN 1559-2294, E-ISSN 1559-2308, Vol. 13, no 9, p. 975-987Article in journal (Refereed)
    Abstract [en]

    Age-related changes in DNA methylation were observed in cross-sectional studies, but longitudinal evidence is still limited. Here, we aimed to characterize longitudinal age-related methylation patterns using 1011 blood samples collected from 385 Swedish twins (age at entry: mean 69 and standard deviation 9.7, 73 monozygotic and 96 dizygotic pairs) up to five times (mean 2.6) over 20 years (mean 8.7). We identified 1316 age-associated methylation sites (P<1.3x10(-7)) using a longitudinal epigenome-wide association study design. We measured how estimated cellular compositions changed with age and how much they confounded the age effect. We validated the results in two independent longitudinal cohorts, where 118 CpGs were replicated in Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS, 390 samples) (P<3.9x10(-5)), 594 in Lothian Birth Cohort (LBC, 3018 samples) (P<5.1x10(-5)) and 63 in both. Functional annotation of age-associated CpGs showed enrichment in CCCTC-binding factor (CTCF) and other transcription factor binding sites. We further investigated genetic influences on methylation and found no interaction between age and genetic effects in the 1316 age-associated CpGs. Moreover, in the same CpGs, methylation differences within twin pairs increased with 6.4% over 10 years, where monozygotic twins had smaller intra-pair differences than dizygotic twins. In conclusion, we show that age-related methylation changes persist in a longitudinal perspective, and are fairly stable across cohorts. The changes are under genetic influence, although this effect is independent of age. Moreover, methylation variability increase over time, especially in age-associated CpGs, indicating the increase of environmental contributions on DNA methylation with age.

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  • 464.
    Ward-Caviness, Cavin K.
    et al.
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany..
    Xu, Tao
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany..
    Aspelund, Thor
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Ctr Publ Hlth, Reykjavik, Iceland..
    Thorand, Barbara
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany..
    Montrone, Corinna
    Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany..
    Meisinger, Christa
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany..
    Dunger-Kaltenbach, Irmtraud
    Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany..
    Zierer, Astrid
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany..
    Yu, Zhonghao
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany..
    Helgadottir, Inga R.
    Iceland Heart Assoc, Kopavogur, Iceland..
    Harris, Tamara B.
    NIA, Bethesda, MD 20892 USA..
    Launer, Lenore J.
    NIA, Bethesda, MD 20892 USA..
    Ganna, Andrea
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Eiriksdottir, Gudny
    Iceland Heart Assoc, Kopavogur, Iceland..
    Waldenberger, Melanie
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany..
    Prehn, Cornelia
    Helmholtz Zentrum Munchen, Inst Expt Genet, Genome Anal Ctr, Neuherberg, Germany..
    Suhre, Karsten
    Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany..
    Illig, Thomas
    Hannover Med Sch, Hannover Unified Biobank, Hannover, Germany..
    Adamski, Jerzy
    Helmholtz Zentrum Munchen, Inst Expt Genet, Genome Anal Ctr, Neuherberg, Germany.;Tech Univ Munich, Chair Expt Genet, Munich, Germany..
    Ruepp, Andreas
    Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany.;Tech Univ Munich, Chair Expt Genet, Munich, Germany..
    Koenig, Wolfgang
    Univ Ulm, Med Ctr, Dept Internal Med 2, Ulm, Germany.;Tech Univ Munich, Deutsches Herzzentrum, Munich, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany..
    Gudnason, Vilmundur
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Emilsson, Valur
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Pharmaceut Sci, Reykjavik, Iceland..
    Wang-Sattler, Rui
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany..
    Peters, Annette
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.;Harvard Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA..
    Improvement of myocardial infarction risk prediction via inflammation-associated metabolite biomarkers2017In: Heart, ISSN 1355-6037, E-ISSN 1468-201X, Vol. 103, no 16, p. 1278-1285Article in journal (Refereed)
    Abstract [en]

    Objective The comprehensive assaying of low-molecular-weight compounds, for example, metabolomics, provides a unique tool to uncover novel biomarkers and understand pathways underlying myocardial infarction (MI). We used a targeted metabolomics approach to identify biomarkers for MI and evaluate their involvement in the pathogenesis of MI.

    Methods and results Using three independent, prospective cohorts (KORA S4, KORA S2 and AGES-REFINE), totalling 2257 participants without a history of MI at baseline, we identified metabolites associated with incident MI (266 cases). We also investigated the association between the metabolites and high-sensitivity C reactive protein (hsCRP) to understand the relation between these metabolites and systemic inflammation. Out of 140 metabolites, 16 were nominally associated (p<0.05) with incident MI in KORA S4. Three metabolites, arginine and two lysophosphatidylcholines (LPC 17: 0 and LPC 18:2), were selected as biomarkers via a backward stepwise selection procedure in the KORA S4 and were significant (p<0.0003) in a meta-analysis comprising all three studies including KORA S2 and AGES-REFINE. Furthermore, these three metabolites increased the predictive value of the Framingham risk score, increasing the area under the receiver operating characteristic score in KORA S4 (from 0.70 to 0.78, p=0.001) and AGES-REFINE study (from 0.70 to 0.76, p=0.02), but was not observed in KORA S2. The metabolite biomarkers attenuated the association between hsCRP and MI, indicating a potential link to systemic inflammatory processes.

    Conclusions We identified three metabolite biomarkers, which in combination increase the predictive value of the Framingham risk score. The attenuation of the hsCRP-MI association by these three metabolites indicates a potential link to systemic inflammation.

  • 465.
    Warren, Helen R.
    et al.
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England..
    Evangelou, Evangelos
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece.;Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece..
    Cabrera, Claudia P.
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England..
    Gao, He
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England..
    Ren, Meixia
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England.;Fujian Med Univ, Fujian Prov Hosp, Dept Cardiol, Fuzhou, Peoples R China..
    Mifsud, Borbala
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England..
    Ntalla, Ioanna
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England..
    Surendran, Praveen
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England..
    Liu, Chunyu
    NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;Boston Univ, Sch Publ Hlth, Boston, MA USA.;NHLBI, Framingham Heart Study, Framingham, MA USA..
    Cook, James P.
    Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England..
    Kraja, Aldi T.
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA.;Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63110 USA..
    Drenos, Fotios
    Univ Bristol, Sch Social & Community Med, MRC Integrat Epidemiol Unit, Bristol, Avon, England.;UCL, Inst Cardiovasc Sci, Ctr Cardiovasc Genet, London, England..
    Loh, Marie
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;ASTAR, Translat Lab Genet Med, Singapore, Singapore..
    Verweij, Niek
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.;Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA..
    Marten, Jonathan
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Karaman, Ibrahim
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Lepe, Marcelo P. Segura
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Bayer Pharma, Berlin, Germany..
    O'Reilly, Paul F.
    Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England..
    Knight, Joanne
    Univ Lancaster, Data Sci Inst, Lancaster, England..
    Snieder, Harold
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Kato, Norihiro
    Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo, Japan..
    He, Jiang
    Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA..
    Tai, E. Shyong
    Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Natl Univ Hlth Syst, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore..
    Said, M. Abdullah
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands..
    Porteous, David
    Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland..
    Alver, Maris
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England..
    Poulter, Neil
    Farrall, Martin
    Univ Oxford, Radcliffe Dept Med, Wellcome Trust Ctr Human Genet, Div Cardiovasc Med, Oxford, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England..
    Gansevoort, Ron T.
    Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, Groningen, Netherlands..
    Padmanabhan, Sandosh
    Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.;Univ Edinburgh, Ctr Genom & Expt Med, Generat Scotland, Edinburgh, Midlothian, Scotland.;Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, British Heart Fdn Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland..
    Magi, Reedik
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England..
    Stanton, Alice
    Royal Coll Surgeons Ireland, Mol & Cellular Therapeut, Dublin, Ireland..
    Connell, John
    Univ Dundee, Ninewells Hosp & Med Sch, Dundee, Scotland..
    Bakker, Stephan J. L.
    Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands..
    Metspalu, Andres
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England..
    Shields, Denis C.
    Univ Coll Dublin, Conway Inst, Sch Med, Dublin, Ireland..
    Thom, Simon
    Imperial Coll London, Natl Heart & Lung Inst, London, England.;Imperial Coll London, Int Ctr Circulatory Hlth, London, England..
    Brown, Morris
    Sever, Peter
    Imperial Coll London, Natl Heart & Lung Inst, London, England..
    Esko, Tonu
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England.;Childrens Hosp, Div Endocrinol, 300 Longwood Ave, Boston, MA 02115 USA.;Broad Inst Harvard & MIT, Cambridge, England..
    Hayward, Caroline
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Genom & Expt Med, Generat Scotland, Edinburgh, Midlothian, Scotland..
    van der Harst, Pim
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands..
    Saleheen, Danish
    Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.;Ctr Noncommun Dis, Karachi, Pakistan.;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Chowdhury, Rajiv
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England..
    Chambers, John C.
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Ealing Hosp Natl Hlth Serv NHS Trust, Southall, Middx, England.;Imperial Coll Healthcare NHS Trust, London, England.;Imperial Coll Healthcare NHS Trust, London, England.;Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore.;Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England..
    Chasman, Daniel I.
    Chakravarti, Aravinda
    Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Baltimore, MD USA..
    Newton-Cheh, Christopher
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Broad Inst Harvard & MIT, Cambridge, England..
    Lindgren, Cecilia M.
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford, England..
    Levy, Daniel
    NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;NHLBI, Framingham Heart Study, Framingham, MA USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA..
    Kooner, Jaspal S.
    Imperial Coll London, Natl Heart & Lung Inst, London, England.;Imperial Coll Healthcare NHS Trust, London, England.;Imperial Coll Healthcare NHS Trust, London, England.;Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England.;Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England.;Imperial Coll London, Cardiovasc Sci, Natl Heart & Lung Inst, Hammersmith Campus, London, England..
    Keavney, Bernard
    Univ Manchester, Fac Biol Med & Hlth, Div Cardiovasc Sci, Manchester, Lancs, England.;Cent Manchester NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Div Med, Manchester, Lancs, England..
    Tomaszewski, Maciej
    Univ Manchester, Fac Biol Med & Hlth, Div Cardiovasc Sci, Manchester, Lancs, England.;Cent Manchester NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Div Med, Manchester, Lancs, England..
    Samani, Nilesh J.
    Howson, Joanna M. M.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England..
    Tobin, Martin D.
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Munroe, Patricia B.
    Ehret, Georg B.
    Wain, Louise V.
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Barnes, Michael R.
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England..
    Tzoulaki, Joanna
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England..
    Caulfield, Mark J.
    Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England.;Queen Mary Univ London, Barts Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, London, England..
    Elliott, Paul
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England.;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England..
    Vaez, Ahmad
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommun Dis, Esfahan, Iran..
    Jansen, Rick
    Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Neurosci Campus Amsterdam, Amsterdam, Netherlands..
    Joehanes, Roby
    NHLBI, Framingham Heart Study, Framingham, MA USA.;Harvard Med Sch, Hebrew SeniorLife, Boston, MA USA..
    van der Most, Peter J.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Erzurumluoglu, A. Mesut
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    O'Reilly, Paul
    Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England..
    Rose, Lynda M.
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA..
    Verwoert, Germaine C.
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
    Hottenga, Jouke-Jan
    Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands..
    Strawbridge, Rona J.
    Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ Sjukhuset, Ctr Mol Med, Solna, Sweden..
    Arking, Dan E.
    Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Baltimore, MD USA..
    Hwang, Shih-Jen
    NHLBI, Populat Sci Branch, US NIH, Bldg 10, Bethesda, MD 20892 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA..
    Guo, Xiuqing
    Harbor UCLA Med Ctr, LABioMed, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA..
    Kutalik, Zoltan
    Univ Lausanne Hosp, Inst Social & Prevent Med, Lausanne, Switzerland.;Swiss Inst Bioinformat, Lausanne, Switzerland..
    Trompet, Stella
    Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands..
    Shrine, Nick
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Teumer, Alexander
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Greifswald, Germany..
    Ried, Janina S.
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany..
    Bis, Joshua C.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA..
    Smith, Albert V.
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Amin, Najaf
    Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands..
    Nolte, Ilja M.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Lyytikainen, Leo-Pekka
    Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Univ Tampere, Sch Med, Dept Clin Chem, Tampere, Finland..
    Mahajan, Anubha
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Wareham, Nicholas J.
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England..
    Hofer, Edith
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria.;Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria..
    Joshi, Peter K.
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Kristiansson, Kati
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Traglia, Michela
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Havulinna, Aki S.
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Goel, Anuj
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England..
    Nalls, Mike A.
    NIA, Neurogenet Lab, US NIH, Bethesda, MD 20892 USA.;Kelly Serv, Rockville, MD USA..
    Sober, Siim
    Univ Tartu, Inst Mol & Cell Biol, Human Mol Genet Res Grp, Tartu, Estonia..
    Vuckovic, Dragana
    Sidra Med & Res Ctr, Expt Genet Div, Doha, Qatar.;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Luan, Jian'an
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England..
    Del Greco M, Fabiola
    European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.;Univ Lubeck, Lubeck, Germany..
    Ayers, Kristin L.
    Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA..
    Marrugat, Jaume
    IMIM, Cardiovasc Epidemiol & Genet, Barcelona, Spain..
    Ruggiero, Daniela
    CNR, Inst Genet & Biophys Buzzati Traverso, Naples, Italy..
    Lopez, Lorna M.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Beaumont Hosp, Educ & Res Ctr, Royal Coll Surg Ireland, Dept Psychiat, Dublin, Ireland.;UCD, Ctr Proteome Res, UCD Conway Inst, Dublin, Ireland..
    Niiranen, Teemu
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Enroth, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Jackson, Anne U.
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    Nelson, Christopher P.
    Univ Leicester, Glenfield Hosp, BHF Cardiovasc Res Ctr, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England..
    Huffman, Jennifer E.
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Zhang, Weihua
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England..
    Gandin, Ilaria
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Harris, Sarah E.
    Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland..
    Zemonik, Tatijana
    Univ Split, Fac Med, Dept Biol, Split, Croatia..
    Lu, Yingchang
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA..
    Shah, Nabi
    Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee, Scotland.;COMSATS Inst Informat Technol, Dept Pharm, Abbottabad, Pakistan..
    de Borst, Martin H.
    Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands..
    Mangino, Massimo
    Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.;Natl Inst Hlth Res, Biomed Res Ctr, London, England..
    Prins, Bram P.
    Wellcome Trust Sanger Inst, Dept Human Genet, Cambridge, England..
    Campbell, Archie
    Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Genom & Expt Med, Generat Scotland, Edinburgh, Midlothian, Scotland..
    Li-Gao, Ruifang
    Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands..
    Chauhan, Ganesh
    Bordeaux Populat Hlth Ctr, INSERM, U1219, Bordeaux, France.;Bordeaux Univ, Bordeaux, France..
    Oldmeadow, Christopher
    Hunter Med Res Inst, New Lambton, NSW, Australia..
    Abecasis, Goncalo
    SPH II, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI USA..
    Abedi, Maryam
    Isfahan Univ Med Sci, Dept Genet & Mol Biol, Esfahan, Iran..
    Barbieri, Caterina M.
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Batini, Chiara
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Blake, Tineka
    Univ Leicester, Dept Hlth Sci, Leicester, Leics, England..
    Boehnke, Michael
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    Bottinger, Erwin P.
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA..
    Braund, Peter S.
    Univ Leicester, Glenfield Hosp, BHF Cardiovasc Res Ctr, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England..
    Brumat, Marco
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Campbell, Harry
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Cocca, Massimiliano
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Collins, Francis
    NHGRI, Med Genom & Metab Genet Branch, US NIH, Bethesda, MD 20892 USA..
    Cordell, Heather J.
    Newcastle Univ, Inst Med Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England..
    Damman, Jeffrey J.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands..
    Davies, Gail
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    de Geus, Eco J.
    Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands..
    de Mutsert, Renee
    Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands..
    Deelen, Joris
    Leiden Univ, Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands..
    Demirkale, Yusuf
    US NIH, Ctr Informat Technol, Bethesda, MD USA..
    Doney, Alex S. F.
    Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee, Scotland..
    Dorr, Marcus
    DZHK German Ctr Cardiovasc Res, Greifswald, Germany.;Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany..
    Ferreira, Teresa
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Franberg, Mattias
    Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ Sjukhuset, Ctr Mol Med, Solna, Sweden.;Stockholm Univ, Dept Numer Anal & Comp Sci, Stockholm, Sweden..
    Giedraitis, Vilmantas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Gieger, Christian
    Helmholtz Zentrum Munchen, Deutsch Forsch Zentrum Gesundheit & Umwelt, Neuherberg, Germany..
    Giulianini, Franco
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA..
    Gow, Alan J.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Heriot Watt Univ, Sch Life Sci, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Hamsten, Anders
    Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ Sjukhuset, Ctr Mol Med, Solna, Sweden..
    Harris, Tamara B.
    NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA..
    Hofman, Albert
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA..
    Holliday, Elizabeth G.
    Hunter Med Res Inst, New Lambton, NSW, Australia..
    Jarvelin, Marjo-Riitta
    Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England.;Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland.;Univ Oulu, Bioctr Oulu, Oulu, Finland.;Oulu Univ Hosp, Unit Primary Care, Oulu, Finland..
    Johansson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Johnson, Andrew D.
    NHLBI, Framingham Heart Study, Framingham, MA USA.;NHLBI, Cardiovasc Epidemiol & Human Genom Branch, Bldg 10, Bethesda, MD 20892 USA..
    Jousilahti, Pekka
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Jula, Antti
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Kahonen, Mika
    Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Univ Tampere, Sch Med, Dept Clin Physiol, Tampere, Finland..
    Kathiresan, Sekar
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA..
    Khaw, Kay-Tee
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Kolcic, Ivana
    Univ Split, Fac Med, Dept Publ Hlth, Split, Croatia..
    Koskinen, Seppo
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Langenberg, Claudia
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England..
    Larson, Marty
    NHLBI, Framingham Heart Study, Framingham, MA USA..
    Launer, Lenore J.
    NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA..
    Lehne, Benjamin
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Liewald, David C. M.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Lin, Li
    Univ Hosp Geneva, Dept Med, Cardiol, Geneva, Switzerland..
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Mach, Francois
    Univ Hosp Geneva, Dept Med, Cardiol, Geneva, Switzerland..
    Mamasoula, Chrysovalanto
    Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne, Tyne & Wear, England..
    Menni, Cristina
    Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England..
    Milaneschi, Yuri
    Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Psychiat, Amsterdam, Netherlands..
    Morgan, Anna
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Morris, Andrew D.
    Univ Edinburgh, Sch Med, Sch Mol Genet & Populat Hlth Sci, Edinburgh, Midlothian, Scotland..
    Morrison, Alanna C.
    Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA..
    Munson, Peter J.
    US NIH, Ctr Informat Technol, Bethesda, MD USA..
    Nandakumar, Priyanka
    Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Baltimore, MD USA..
    Nguyen, Quang Tri
    Nutile, Teresa
    CNR, Inst Genet & Biophys Buzzati Traverso, Naples, Italy..
    Oldehinkel, Albertine J.
    Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands..
    Oostra, Ben A.
    Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands..
    Org, Elin
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. Imperial Coll London, Sch Publ Hlth, Imperial Clin Trials Unit, London, England..
    Palotie, Aarno
    Univ Helsinki, FIMM, Helsinki, Finland..
    Pare, Guillaume
    McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada..
    Pattie, Alison
    Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Penninx, Brenda W. J. H.
    Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Psychiat, Amsterdam, Netherlands..
    Pramstaller, Peter P.
    European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.;Univ Lubeck, Lubeck, Germany.;Gen Cent Hosp, Dept Neurol, Bolzano, Italy.;Univ Lubeck, Dept Neurol, Lubeck, Germany..
    Raitakari, Olli T.
    Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland..
    Rice, Kenneth
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA..
    Ridker, Paul M.
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA..
    Riese, Harriette
    Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands..
    Ripatti, Samuli
    Univ Helsinki, FIMM, Helsinki, Finland..
    Robino, Antonietta
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy..
    Rotter, Jerome I.
    Harbor UCLA Med Ctr, LABioMed, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.;Harbor UCLA Med Ctr, LABioMed, Dept Med, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA..
    Rudan, Igor
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Saba, Yasaman
    Med Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, Graz, Austria..
    Saint Pierre, Aude
    European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.;Univ Lubeck, Lubeck, Germany.;Etab Francais Sang, INSERM, U1078, Brest, France..
    Sala, Cinzia F.
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Sarin, Antti-Pekka
    Univ Helsinki, FIMM, Helsinki, Finland..
    Schmidt, Reinhold
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria..
    Scott, Rodney
    Hunter Med Res Inst, New Lambton, NSW, Australia.;Univ Newcastle, Fac Hlth, Callaghan, NSW, Australia.;John Hunter Hosp, Sch Biomed Sci & Pharm, New Lambton, NSW, Australia..
    Seelen, Marc A.
    Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands..
    Siscovick, David
    New York Acad Med, New York, NY USA..
    Sorice, Rossella
    CNR, Inst Genet & Biophys Buzzati Traverso, Naples, Italy.;IRCCS Neuromed, Pozzilli, Italy..
    Stott, David J.
    Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland..
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Swertz, Morris
    Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands..
    Taylor, Kent D.
    Harbor UCLA Med Ctr, Los Angeles BioMed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.;Harbor UCLA Med Ctr, Dept Pediat, Div Genet Outcomes, Torrance, CA 90509 USA..
    Tzoulaki, Ioanna
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Tzourio, Christophe
    Bordeaux Populat Hlth Ctr, INSERM, U1219, Bordeaux, France.;Bordeaux Univ, Bordeaux, France.;Bordeaux Univ Hosp, Dept Publ Hlth, Bordeaux, France..
    Uitterlinden, Andre G.
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands..
    Volker, Uwe
    DZHK German Ctr Cardiovasc Res, Greifswald, Germany.;Univ Med Greifswald, Interfac Inst Genet & Funct Gen, Greifswald, Germany..
    Vollenweider, Peter
    CHU Vaudois, Univ Lausanne Hosp, Dept Internal Med, Lausanne, Switzerland..
    Wild, Sarah
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Willemsen, Gonneke
    Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands..
    Wright, Alan F.
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Yao, Jie
    Harbor UCLA Med Ctr, LABioMed, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA..
    Theriault, Sebastien
    McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada..
    Conen, David
    McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada..
    John, Attia
    Hunter Med Res Inst, New Lambton, NSW, Australia.;Univ Newcastle, Fac Hlth, Callaghan, NSW, Australia.;John Hunter Hosp, Sch Biomed Sci & Pharm, New Lambton, NSW, Australia..
    Debette, Stephanie
    Bordeaux Populat Hlth Ctr, INSERM, U1219, Bordeaux, France.;Bordeaux Univ, Bordeaux, France.;Bordeaux Univ Hosp, Dept Neurol, Bordeaux, France..
    Mook-Kanamori, Dennis O.
    Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands..
    Zeggini, Eleftheria
    Wellcome Trust Sanger Inst, Dept Human Genet, Cambridge, England..
    Spector, Tim D.
    Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England..
    Palmer, Colin N. A.
    Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee, Scotland..
    Vergnaud, Anne-Claire
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Loos, Ruth J. F.
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria.;Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth Dev Inst, New York, NY 10029 USA..
    Polasek, Ozren
    Univ Split, Fac Med, Dept Publ Hlth, Split, Croatia..
    Starr, John M.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh, Midlothian, Scotland..
    Girotto, Giorgia
    Sidra Med & Res Ctr, Expt Genet Div, Doha, Qatar.;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Lindgren, Cecila M.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Broad Inst Harvard & MIT, Cambridge, England..
    Vitart, Veronique
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Tuomilehto, Jaakko
    Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland.;South Ostrobothnia Cent Hosp, Seinajoki, Finland.;Hosp Univ La Paz, Red RECAVA Grp RD06 0014 0015, Madrid, Spain.;Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria..
    Gyllensten, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Knekt, Paul
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Deary, Ian J.
    Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland..
    Ciullo, Marina
    CNR, Inst Genet & Biophys Buzzati Traverso, Naples, Italy.;IRCCS Neuromed, Pozzilli, Italy..
    Elosua, Roberto
    IMIM, Cardiovasc Epidemiol & Genet, Barcelona, Spain..
    Keavney, Bernard D.
    Univ Manchester, Fac Biol Med & Hlth, Div Cardiovasc Sci, Manchester, Lancs, England..
    Hicks, Andrew A.
    European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.;Univ Lubeck, Lubeck, Germany..
    Scott, Robert A.
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England..
    Gasparini, Paolo
    Sidra Med & Res Ctr, Expt Genet Div, Doha, Qatar.;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy..
    Laan, Maris
    Univ Tartu, Inst Mol & Cell Biol, Human Mol Genet Res Grp, Tartu, Estonia.;Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia..
    Liu, YongMei
    Wake Forest Sch Med, Div Publ Hlth Sci, Winston Salem, NC USA..
    Watkins, Hugh
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England..
    Hartman, Catharina A.
    Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands..
    Salomaa, Veikko
    Natl Inst Hlth & Welf THL, Dept Hlth, Helsinki, Finland..
    Toniolo, Daniela
    Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy..
    Perola, Markus
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.;Univ Helsinki, FIMM, Helsinki, Finland.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia..
    Wilson, James F.
    Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Schmidt, Helena
    Med Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, Graz, Austria.;Med Univ Graz, Dept Neurol, Graz, Austria..
    Zhao, Jing Hua
    Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England..
    Lehtimaki, Terho
    Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Univ Tampere, Sch Med, Dept Clin Chem, Tampere, Finland..
    van Duijn, Cornelia M.
    Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands..
    Gudnason, Vilmundur
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Psaty, Bruce M.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.;Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA.;Grp Hlth, Grp Hlth Res Inst, Seattle, WA USA..
    Peters, Annette
    Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany..
    Rettig, Rainer
    Univ Med Greifswald, Inst Physiol, Karlsburg, Germany..
    James, Alan
    Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep, Nedlands, WA, Australia.;Univ Western Australia, Sch Med & Pharmacol, Crawley, WA, Australia..
    Jukema, J. Wouter
    Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands..
    Strachan, David P.
    St Georges Univ London, Populat Hlth Res Inst, London, England..
    Palmas, Walter
    Columbia Univ, Med Ctr, Dept Med, New York, NY USA..
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA..
    Boomsma, Dorret I.
    Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands..
    Franco, Oscar H.
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
    Bochud, Murielle
    Univ Lausanne Hosp, Inst Social & Prevent Med, Lausanne, Switzerland..
    Morris, Andrew P.
    Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk2017In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 49, no 3, p. 403-415Article in journal (Refereed)
    Abstract [en]

    Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.

  • 466.
    Wiberg, Bernice
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Kilander, Lena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Byberg, Liisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    The relationship between executive dysfunction and post-stroke mortality: a population-based cohort study2012In: BMJ Open, E-ISSN 2044-6055, Vol. 2, no 3, p. e000458-Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES:

    To study the associations of pre-stroke cognitive performance with mortality after first-ever stroke or transient ischaemic attack (TIA).

    DESIGN:

    A prospective cohort study.

    SETTING AND PARTICIPANTS:

    In participants having first-ever stroke or TIA during up to 14 years of post-test follow-up (n=155), we investigated the associations of pre-stroke variables and cognitive test results with post-stroke survival. The study is based on those participants of the Uppsala Longitudinal Study of Adult Men who performed cognitive function tests at approximately age 70 (n=919).

    PRIMARY OUTCOME MEASURES:

    Mortality after first-ever stroke or TIA related to pre-stroke executive performance.

    RESULTS:

    Eighty-four (54%) of the first-ever stroke/TIA patients died under a median follow-up of 2.5 years after the event. In Cox proportional hazard analyses adjusting for age, education, social group and traditional stroke risk factors, poor performance in Trail Making Test (TMT)-A was related to mortality (HR 1.88 per SD, 95% CI 1.31 to 2.71, p=0.001). The risk of mortality was approximately threefold higher in the highest tertile compared with the lowest tertile (HR TMT-A= 2.90 per SD, 95% CI 1.24 to 6.77, p=0.014). A similar pattern was seen for TMT-B, but Mini-Mental State Examination results were not related to risk of post-stroke mortality.

    CONCLUSION:

    Executive performance measured by TMT-A and -B before stroke was independently associated with long-term risk of mortality, after first-ever stroke or TIA in a population-based study of older men.

  • 467.
    Wiberg, Bernice
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Lind, Monica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Serum levels of monobenzylphthalate (MBzP) is related to carotid atherosclerosis in the elderly2014In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 133, p. 348-352Article in journal (Refereed)
    Abstract [en]

    Background and objective: Background exposure to environmental contaminants has recently emerged as a new risk factor for cardiovascular disease in general and to atheroclerosis in particular. This cross-sectional study was performed to evaluate if serum concentrations of the phthalate metabolite monobenzylphthalate (MBzP) are related to atheroclerosis in the carotid arteries. Methods: In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1003 subjects all aged 70) the prevalence of overt plaques and echogenicity (gray-scale median, GSM) of carotid artery plaques were recorded by ultrasound in both of the carotid arteries. The intima-media thickness (IMT) and echogenicity (IM-GSM) of the intima-media complex were also measured. The phthalate metabolite MBzP was analyzed in serum by a liquid chromatograph/tandem mass spectrometer. Results: The circulating level of the phthalate MBzP was related to intima-media thickness (IMT) when adjusting for gender, blood pressure, body mass index (BMI), waist circumference, HDL- and LDL-cholesterol, serum triglycerides, blood glucose and smoking (p=0.034). High levels of MBzP were also strongly associated with an echogenic IM-GSM and plaque GSM (p=0.0001 for both outcomes after adjustment) but not to plaque prevalence (p=0.42). Conclusion: The phthalate metabolite MBzP was strongly related to the echogenicity of intima-media and plaques and also to IMT, independently of traditional CV risk factors. This suggests a role for the phthalate MBzP in the development of atherosclerosis.

  • 468. Wierup, Ia
    et al.
    Carlsson, Axel C.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Wandell, Per
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Ärnlov, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Borne, Yan
    Low anthropometric measures and mortality-results from the Malmo Diet and Cancer Study2015In: Annals of Medicine, ISSN 0785-3890, E-ISSN 1365-2060, Vol. 47, no 4, p. 325-331Article in journal (Refereed)
    Abstract [en]

    Aim. To study the association between anthropometric measures: body mass index (BMI), percent body fat, waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), waist-to-hip-to-height ratio (WHHR), and A Body Shape Index (ABSI); to see if individuals in the lowest 5 percentiles for these measures have an increased risk of mortality. Methods. A population-based prospective cohort study ( 10,304 men and 16,549 women), the Malmo Diet and Cancer study (MDC), aged 45-73 years. Results. During a mean follow-up of 14 +/- 3 years, 2,224 men and 1,983 women died. There was a significant increased mortality risk after adjustments for potential confounders in the group with the 5% lowest BMI ( referent 25%-75%); hazard ratios (HR) with 95% confidence intervals were 1.33 (1.10-1.61) for women and 1.27 (1.07-1.52) for men. A similar significant increased mortality risk was seen with the 5% lowest percent body fat, HR 1.31 (1.07-1.60) for women and 1.25 (1.04-1.50) for men. Women with an ABSI in the lowest 5 percentiles had a lower mortality risk HR 0.64 (0.48-0.85). Conclusion. These results imply that BMI or percent body fat could be used to identify lean individuals at increased mortality risk.

  • 469.
    Wild, Philipp S.
    et al.
    Prevent Cardiol & Prevent Med, Dept Med 2, Beijing, Peoples R China.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Mainz, Germany.;DZHK German Ctr Cardiovasc Res Partner Site Rhine, Mainz, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol, Langen beckstr 1, D-55131 Mainz, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Langen beckstr 1, D-55131 Mainz, Germany..
    Felix, Janine F.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Room Na 2906,POB 2040, NL-3000 CA Rotterdam, Netherlands..
    Schillert, Arne
    Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany.;DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany..
    Teumer, Alexander
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK Partner Site Greifswald, Greifswald, Germany..
    Chen, Ming-Huei
    Boston Univ, Sch Med, Dept Neurol, Boston, MA 02215 USA..
    Leening, Maarten J. G.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Cardiol, Erasmus MC, Rotterdam, Netherlands..
    Voelker, Uwe
    DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany..
    Grossmann, Vera
    Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Mainz, Germany..
    Brody, Jennifer A.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA..
    Irvin, Marguerite R.
    Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA..
    Shah, Sanjiv J.
    Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA..
    Pramana, Setia
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Lieb, Wolfgang
    Christian Albrechts Univ Kiel, Inst Epidemiol & Popgen Biobank, Kiel, Germany..
    Schmidt, Reinhold
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria..
    Stanton, Alice V.
    Beaumont Hosp, Blood Pressure Unit, Dublin, Ireland.;Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin, Ireland..
    Malzahn, Doerthe
    Georg August Univ, Univ Med Ctr, Dept Genet Epidemiol, Gottingen, Germany..
    Smith, Albert Vernon
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Minelli, Cosetta
    Imperial Coll London, Natl Heart & Lung Inst NHLI, Populat Hlth & Occupat Dis, London, England..
    Ruggiero, Daniela
    Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy..
    Lyytikainen, Leo-Pekka
    Dept Clin Chem, Fimlab Labs, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Tampere, Finland..
    Tiller, Daniel
    Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol, Biostat & Informat, Halle, Germany..
    Smith, J. Gustav
    Lund Univ, Dept Cardiol, Lund, Sweden.;Skane Univ Hosp, Lund, Sweden.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA USA..
    Monnereau, Claire
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Generat R Study Grp, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Pediat, Erasmus MC, Rotterdam, Netherlands..
    Di Tullio, Marco R.
    Columbia Univ, Med Ctr, Dept Med, New York, NY USA..
    Musani, Solomon K.
    Univ Mississippi, Med Ctr, Jackson Heart Study, Jackson, MS 39216 USA..
    Morrison, Alanna C.
    Univ Texas Hlth Sci Ctr Houston, Dept Epidemiol, Human Genet & Environm Sci, Houston, TX USA..
    Pers, Tune H.
    Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.;Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark..
    Morley, Michael
    Univ Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Div Cardiovasc Med, Philadelphia, PA 19104 USA..
    Kleber, Marcus E.
    Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany..
    Aragam, Jayashri
    Harvard Med Sch, Boston, MA USA.;Vet Adm Hosp, West Roxbury, Boston, MA USA..
    Benjamin, Emelia J.
    Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Boston Univ, Sch Med & Publ Hlth, Sect Cardiol, Prevent Med & Epidemiol, Boston, MA USA..
    Bis, Joshua C.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA..
    Bisping, Egbert
    Med Univ Graz, Dept Cariol, Graz, Austria..
    Broeckel, Ulrich
    Med Coll Wisconsin, Milwaukee, WI 53226 USA..
    Cheng, Susan
    Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA USA..
    Deckers, Jaap W.
    Univ Med Ctr Rotterdam, Dept Cardiol, Erasmus MC, Rotterdam, Netherlands..
    Del Greco, Fabiola
    Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany..
    Edelmann, Frank
    Charite Univ Med Berlin, Dept Cardiol, Campus Virchow Klinikum, Berlin, Germany..
    Fornage, Myriam
    Univ Texas Hlth Sci Ctr, Houston, TX USA..
    Franke, Lude
    Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands..
    Friedrich, Nele
    DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Inst Clin Chem, Greifswald, Germany.;Univ Med Greifswald, Lab Med, Greifswald, Germany..
    Harris, Tamara B.
    Natl Inst Aging, NIH, Lab Epidemiol Demog & Biometry, Bethesda, MD USA..
    Hofer, Edith
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria.;Med Univ Graz, Inst Med Informat, Stat & Documentat, Graz, Austria..
    Hofman, Albert
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands..
    Huang, Jie
    Boston VA Res Inst, Boston, MA USA.;Harvard Med Sch, Brigham & Womens Hosp, Div Aging, Boston, MA USA..
    Hughes, Alun D.
    UCL, Inst Cardiovasc Sci, London, England..
    Kahonen, Mika
    Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Physiol, Tampere, Finland..
    Kruppa, Jochen
    Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany.;Univ Vet Med, Fdn Inst Vet Med & Genet, Hannover, Germany..
    Lackner, Karl J.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics. Univ Med Ctr Mainz, Inst Clin Chem & Lab Med, Mainz, Germany.
    Lannfelt, Lars
    Univ Med Ctr Mainz, Dept Med 2, Mainz, Germany..
    Laskowski, Rafael
    Univ Med Ctr Mainz, Dept Med 2, Mainz, Germany..
    Launer, Lenore J.
    Natl Inst Aging, NIH, Neuroepidemiol Sect, Bethesda, MD USA..
    Leosdottir, Margret
    Lund Univ, Dept Cardiol, Lund, Sweden.;Skane Univ Hosp, Malmo, Sweden..
    Lin, Honghuang
    Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Boston Univ, Sch Med, Dept Med, Sect Computat Biomed, Boston, MA 02215 USA..
    Lindgren, Cecilia M.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Univ, Cambridge, MA 02138 USA..
    Loley, Christina
    Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany..
    MacRae, Calum A.
    MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Univ, Cambridge, MA 02138 USA.;Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA..
    Mascalzoni, Deborah
    Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany..
    Mayet, Jamil
    Hammersmith Hosp, Int Ctr Circulatory Hlth, London, England.;NHLI, Imperial Coll London, London, England..
    Medenwald, Daniel
    Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol, Biostat & Informat, Halle, Germany..
    Morris, Andrew P.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England..
    Mueller, Christian
    Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany..
    Mueller-Nurasyid, Martina
    Ludwig Maximilians Univ Munchen, Dept Med 1, Munich, Germany.;DZHK Partner Site Munich Heart Alliance, Munich, Germany.;Inst Genet Epidemiol, Helmholtz Zentrum Munchen German Res Ctr Environm, Neuherberg, Germany..
    Nappo, Stefania
    Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy..
    Nilsson, Peter M.
    Lund Univ, Dept Clin Sci, Malmo, Sweden.;Skane Univ Hosp, Dept Internal Med, Malmo, Sweden..
    Nuding, Sebastian
    Univ Clin Halle Saale, Martin Luther Univ Halle Wittenberg, Dept Med 3, Halle, Germany..
    Nutile, Teresa
    Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy..
    Peters, Annette
    DZHK Partner Site Munich Heart Alliance, Munich, Germany.;Inst Epidemiol II, Helmholtz Zentrum Munchen German Res Ctr Environm, Neuherberg, Germany..
    Pfeufer, Arne
    Inst Human Genet, Helmholtz Zentrum Munchen, Neuherberg, Germany..
    Pietzner, Diana
    Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol, Biostat & Informat, Halle, Germany..
    Pramstaller, Peter P.
    Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany.;Gen Cent Hosp, Dept Neurol, Bolzano, Italy.;Univ Lubeck, Dept Neurol, Lubeck, Germany..
    Raitakari, Olli T.
    Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland..
    Rice, Kenneth M.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA..
    Rivadeneira, Fernando
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Generat R Study Grp, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands..
    Rotter, Jerome I.
    Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA USA.;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA USA..
    Ruohonen, Saku T.
    Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland..
    Sacco, Ralph L.
    Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL USA.;Univ Miami, Miller Sch Med, McKnight Brain Inst Miller, Miami, FL USA.;Univ Miami, Dept Publ Hlth Sci, Miami, FL USA.;Univ Miami, Dept Human Gen, Miami, FL USA..
    Samdarshi, Tandaw E.
    Univ Mississippi, Med Ctr, Div Cardiol, Jackson, MS 39216 USA..
    Schmidt, Helena
    Med Univ Graz, Inst Mol Biol & Biochem, Graz, Austria..
    Sharp, Andrew S. P.
    Royal Devon & Exeter Hosp & Univ Exeter, Dept Cardiol, Exeter, Devon, England..
    Shields, Denis C.
    Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Dublin, Ireland.;Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland..
    Sorice, Rossella
    Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy.;IRCCS Neuromed, Pozzilli, Isernia, Italy..
    Sotoodehnia, Nona
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Div Cardiol, Seattle, WA 98195 USA..
    Stricker, Bruno H.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands.;Inspectorate Hlth Care, Utrecht, Netherlands..
    Surendran, Praveen
    Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin, Ireland.;Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland..
    Thom, Simon
    Hammersmith Hosp, Int Ctr Circulatory Hlth, London, England.;NHLI, Imperial Coll London, London, England..
    Toeglhofer, Anna M.
    Med Univ Graz, Inst Mol Biol & Biochem, Graz, Austria..
    Uitterlinden, Andre G.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands..
    Wachter, Rolf
    Georg August Univ, Univ Med Ctr Gottingen, Dept Cardiol & Pneumol, Gottingen, Germany..
    Voelzke, Henry
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK Partner Site Greifswald, Greifswald, Germany..
    Ziegler, Andreas
    Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany.;DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany.;Univ KwaZulu Natal, Sch Math, Stat & Comp Sci, Durban, South Africa.;Univ Lubeck, Zentrum Klin Studien, Lubeck, Germany..
    Muenzel, Thomas
    DZHK German Ctr Cardiovasc Res Partner Site Rhine, Mainz, Germany.;Univ Med Ctr Mainz, Dept Med 2, Mainz, Germany..
    Maerz, Winfried
    Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany.;Synlab Acad, Synlab Serv GmbH, Mannheim, Germany.;Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria..
    Cappola, Thomas P.
    Univ Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Div Cardiovasc Med, Philadelphia, PA 19104 USA..
    Hirschhorn, Joel N.
    Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Harvard Med Sch, Dept Genet, Boston, MA USA..
    Mitchell, Gary F.
    Cardiovasc Engn Inc, Norwood, MA USA..
    Smith, Nicholas L.
    Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.;Grp Hlth Res Inst, Grp Hlth Cooperat, Seattle, WA USA.;Seattle Epidemiol Res & Informat Ctr, Dept Vet Affairs Off Res & Dev, Seattle, WA USA..
    Fox, Ervin R.
    Univ Mississippi, Med Ctr, Div Cardiol, Jackson, MS 39216 USA..
    Dueker, Nicole D.
    Univ Miami, Miller Sch Med, John P Hussman Inst Human Gen, Miami, FL USA..
    Jaddoe, Vincent W. V.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Generat R Study Grp, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Pediat, Erasmus MC, Rotterdam, Netherlands..
    Melander, Olle
    Lund Univ, Dept Clin Sci, Malmo, Sweden.;Skane Univ Hosp, Dept Internal Med, Malmo, Sweden..
    Russ, Martin
    Univ Clin Halle Saale, Martin Luther Univ Halle Wittenberg, Dept Med 3, Halle, Germany.;Helios Amperklin Dachau, Dachau, Germany..
    Lehtimaki, Terho
    Dept Clin Chem, Fimlab Labs, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Tampere, Finland..
    Ciullo, Marina
    Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy.;IRCCS Neuromed, Pozzilli, Isernia, Italy..
    Hicks, Andrew A.
    Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany..
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Gudnason, Vilmundur
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Pieske, Burkert
    Med Univ Graz, Dept Cariol, Graz, Austria.;Charite Univ Med Berlin, Dept Cardiol, Campus Virchow Klinikum, Berlin, Germany.;German Heart Inst Berlin DHZB, Dept Internal Med Cardiol, Berlin, Germany..
    Barron, Anthony J.
    Hammersmith Hosp, Int Ctr Circulatory Hlth, London, England.;NHLI, Imperial Coll London, London, England..
    Zweiker, Robert
    Med Univ Graz, Dept Cariol, Graz, Austria..
    Schunkert, Heribert
    DZHK Partner Site Munich Heart Alliance, Munich, Germany.;Tech Univ Munich, Deutsches Herzzentrum, Munich, Germany..
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA..
    Liu, Kiang
    Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA..
    Arnett, Donna K.
    Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA..
    Psaty, Bruce M.
    Grp Hlth Res Inst, Grp Hlth Cooperat, Seattle, WA USA.;Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Epidemiol & Hlth Serv, Seattle, WA 98195 USA..
    Blankenberg, Stefan
    DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany.;Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany..
    Larson, Martin G.
    Boston Univ, Sch Publ Hlth, Biostat Dept, Boston, MA 02215 USA.;Boston Univ, Dept Math & Stat, Boston, MA USA..
    Felix, Stephan B.
    DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Dept Internal Med B, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany..
    Franco, Oscar H.
    Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands..
    Zeller, Tanja
    DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany.;Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany..
    Vasan, Ramachandran S.
    Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Boston Univ, Sch Med & Publ Hlth, Sect Cardiol, Prevent Med & Epidemiol, Boston, MA USA.;Boston Univ, Sch Med & Framingham Heart Study, Dept Med, Sect Prevent Med & Epidemiol & Cardiol, 801 Massachusetts Ave,Suite 470, Boston, MA 02118 USA..
    Doerr, Marcus
    DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Dept Internal Med B, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany..
    Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function2017In: Journal of Clinical Investigation, ISSN 0021-9738, E-ISSN 1558-8238, Vol. 127, no 5, p. 1798-1812Article in journal (Refereed)
    Abstract [en]

    BACKGROUND. Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS. A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen consortium). The analysis included 16 traits of left ventricular (LV) structure, and systolic and diastolic function. RESULTS. The discovery analysis included 21 cohorts for structural and systolic function traits (n = 32,212) and 17 cohorts for diastolic function traits (n = 21,852). Replication was performed in 5 cohorts (n = 14,321) and 6 cohorts (n = 16,308), respectively. Besides 5 previously reported loci, the combined meta-analysis identified 10 additional genome-wide significant SNPs: rs12541595 near MTSS1 and rs10774625 in ATXN2 for LV end-diastolic internal dimension; rs806322 near KCNRG, rs4765663 in CACNA1C, rs6702619 near PALMD, rs7127129 in TMEM16A, rs11207426 near FGGY, rs17608766 in GOSR2, and rs17696696 in CFDP1 for aortic root diameter; and rs12440869 in IQCH for Doppler transmitral A-wave peak velocity. Findings were in part validated in other cohorts and in GWAS of related disease traits. The genetic loci showed associations with putative signaling pathways, and with gene expression in whole blood, monocytes, and myocardial tissue. CONCLUSION. The additional genetic loci identified in this large meta-analysis of cardiac structure and function provide insights into the underlying genetic architecture of cardiac structure and warrant follow-up in future functional studies.

  • 470. Willeit, P.
    et al.
    Thompson, S. G.
    Agewall, S.
    Bergstrom, G.
    Bickel, H.
    Catapano, A. L.
    Chien, K. L.
    de Groot, E.
    Empana, J. P.
    Etgen, T.
    Franco, O. H.
    Iglseder, B.
    Johnsen, S. H.
    Kavousi, M.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Liu, J.
    Mathiesen, E. B.
    Norata, G. D.
    Olsen, M. H.
    Papagianni, A.
    Poppert, H.
    Price, J. F.
    Sacco, R. L.
    Yanez, D. N.
    Zhao, D.
    Schminke, U.
    Buelbuel, A.
    Polak, J. F.
    Sitzer, M.
    Hofman, A.
    Grigore, L.
    Doerr, M.
    Su, T. C.
    Ducimetiere, P.
    Xie, W.
    Ronkainen, K.
    Kiechl, S.
    Rundek, T.
    Robertson, C.
    Fagerberg, B.
    Bokemark, L.
    Steinmetz, H.
    Ikram, M. A.
    Voelzke, H.
    Lin, H. J.
    Plichart, M.
    Tuomainen, T. P.
    Desvarieux, M.
    McLachlan, S.
    Schmidt, C.
    Kauhanen, J.
    Willeit, J.
    Lorenz, M. W.
    Sander, D.
    Inflammatory markers and extent and progression of early atherosclerosis: Pooled analysis of individual participant data from 20 prospective studies of the PROG-IMT collaboration2014In: International Journal of Stroke, ISSN 1747-4930, E-ISSN 1747-4949, Vol. 9, p. 27-27Article in journal (Other academic)
  • 471.
    Willeit, Peter
    et al.
    Univ Cambridge, Cambridge, England.;Med Univ Innsbruck, Innsbruck, Austria..
    Kaptoge, Stephen
    Univ Cambridge, Cambridge, England..
    Welsh, Paul
    Univ Glasgow, Glasgow, Lanark, Scotland..
    Butterworth, Adam S.
    Univ Cambridge, Cambridge, England..
    Chowdhury, Rajiv
    Univ Cambridge, Cambridge, England..
    Spackman, Sarah A.
    Univ Cambridge, Cambridge, England..
    Pennells, Lisa
    Univ Cambridge, Cambridge, England..
    Gao, Pei
    Univ Cambridge, Cambridge, England.;Peking Univ, Beijing, Peoples R China..
    Burgess, Stephen
    Univ Cambridge, Cambridge, England..
    Freitag, Daniel F.
    Univ Cambridge, Cambridge, England..
    Sweeting, Michael
    Univ Cambridge, Cambridge, England..
    Wood, Angela M.
    Univ Cambridge, Cambridge, England..
    Cook, Nancy R.
    Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA..
    Judd, Suzanne
    Univ Alabama Birmingham, Birmingham, AL 35487 USA..
    Trompet, Stella
    Leiden Univ, Med Ctr, Leiden, Netherlands..
    Nambi, Vijay
    Michael E DeBakey Baylor Coll Med, Houston, TX 77030 USA.;Houston Methodist DeBakey Heart & Vasc Ctr, Houston, TX 77030 USA..
    Olsen, Michael Hecht
    Odense Univ Hosp, Odense, Denmark..
    Everett, Brendan M.
    Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA..
    Kee, Frank
    Queens Univ Belfast, Belfast, Antrim, North Ireland..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Salomaa, Veikko
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Levy, Daniel
    NIH, Bldg 10, Bethesda, MD 20892 USA..
    Kauhanen, Jussi
    Univ Eastern Finland, Kuopio, Finland..
    Laukkanen, Jari A.
    Univ Eastern Finland, Kuopio, Finland..
    Kavousi, Maryam
    Erasmus MC, Rotterdam, Netherlands..
    Ninomiya, Toshiharu
    Kyushu Univ, Fukuoka, Japan..
    Casas, Juan-Pablo
    UCL, Farr Inst Hlth Informat, London, England..
    Daniels, Lori B.
    Univ Calif San Diego, San Diego, CA 92103 USA..
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Kistorp, Caroline N.
    Univ Copenhagen, Copenhagen, Denmark.;Herlev Hosp, Copenhagen, Denmark..
    Rosenberg, Jens
    Copenhagen Univ Hosp, Glostrup, Denmark..
    Mueller, Thomas
    Konventhosp Barmherzige Bruder, Linz, Austria..
    Rubattu, Speranza
    Univ Roma La Sapienza, Rome, Italy.;Ist Ricovero & Cura Carattere Sci Neuromed, Pozzilli, Italy..
    Panagiotakos, Demosthenes B.
    Harokopio Univ Athens, Athens, Greece..
    Franco, Oscar H.
    Erasmus MC, Rotterdam, Netherlands..
    de Lemos, James A.
    Univ Texas Southwestern Med Sch, Dallas, TX 75390 USA..
    Luchner, Andreas
    Univ Klinikum Regensburg, Regensburg, Germany.;Klinikum St Marien, Amberg, Germany..
    Kizer, Jorge R.
    Albert Einstein Coll Med, Bronx, NY 10467 USA..
    Kiechl, Stefan
    Med Univ Innsbruck, Innsbruck, Austria..
    Salonen, Jukka T.
    Metab Analyt Serv, Helsinki, Finland..
    Wannamethee, S. Goya
    UCL, London, England..
    de Boer, Rudolf A.
    Univ Groningen, Groningen, Netherlands..
    Nordestgaard, Borge G.
    Univ Copenhagen, Copenhagen, Denmark..
    Andersson, Jonas
    Umea Univ, Umea, Sweden..
    Jorgensen, Torben
    Res Ctr Prevent & Hlth, Glostrup, Denmark..
    Melander, Olle
    Malmo Univ Hosp, Malmo, Sweden..
    Ballantyne, Christie M.
    Houston Methodist DeBakey Heart & Vasc Ctr, Houston, TX 77030 USA.;Baylor Coll Med, Houston, TX 77030 USA..
    DeFilippi, Christopher
    Univ Maryland, Sch Med, Baltimore, MD 21201 USA..
    Ridker, Paul M.
    Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA..
    Cushman, Mary
    Univ Vermont, Burlington, VT 05405 USA..
    Rosamond, Wayne D.
    Univ N Carolina, Chapel Hill, NC 27514 USA..
    Thompson, Simon G.
    Univ Cambridge, Cambridge, England..
    Gudnason, Vilmundur
    Icelandic Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Reykjavik, Iceland..
    Sattar, Naveed
    Univ Glasgow, Glasgow, Lanark, Scotland..
    Danesh, John
    Univ Cambridge, Cambridge, England..
    Di Angelantonio, Emanuele
    Univ Cambridge, Cambridge, England..
    Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis2016In: The Lancet Diabetes and Endocrinology, ISSN 2213-8587, E-ISSN 2213-8595, Vol. 4, no 10, p. 840-849Article in journal (Refereed)
    Abstract [en]

    Background Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable a more integrated approach than at present by predicting heart failure and enhancing coronary heart disease and stroke risk assessment. Methods In this individual-participant-data meta-analysis, we generated and harmonised individual-participant data from relevant prospective studies via both de-novo NT-proBNP concentration measurement of stored samples and collection of data from studies identified through a systematic search of the literature (PubMed, Scientific Citation Index Expanded, and Embase) for articles published up to Sept 4, 2014, using search terms related to natriuretic peptide family members and the primary outcomes, with no language restrictions. We calculated risk ratios and measures of risk discrimination and reclassification across predicted 10 year risk categories (ie, <5%, 5% to <7.5%, and >= 7.5%), adding assessment of NT-proBNP concentration to that of conventional risk factors (ie, age, sex, smoking status, systolic blood pressure, history of diabetes, and total and HDL cholesterol concentrations). Primary outcomes were the combination of coronary heart disease and stroke, and the combination of coronary heart disease, stroke, and heart failure. Findings We recorded 5500 coronary heart disease, 4002 stroke, and 2212 heart failure outcomes among 95617 participants without a history of cardiovascular disease in 40 prospective studies. Risk ratios (for a comparison of the top third vs bottom third of NT-proBNP concentrations, adjusted for conventional risk factors) were 1.76 (95% CI 1.56-1.98) for the combination of coronary heart disease and stroke and 2.00 (1.77-2.26) for the combination of coronary heart disease, stroke, and heart failure. Addition of information about NT-proBNP concentration to a model containing conventional risk factors was associated with a C-index increase of 0.012 (0.010-0.014) and a net reclassification improvement of 0.027 (0.019-0.036) for the combination of coronary heart disease and stroke and a C-index increase of 0.019 (0.016-0.022) and a net reclassification improvement of 0.028 (0.019-0.038) for the combination of coronary heart disease, stroke, and heart failure. Interpretation In people without baseline cardiovascular disease, NT-proBNP concentration assessment strongly predicted first-onset heart failure and augmented coronary heart disease and stroke prediction, suggesting that NT-proBNP concentration assessment could be used to integrate heart failure into cardiovascular disease primary prevention. Copyright (C) 2016 The Author(s). Published by Elsevier Ltd

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  • 472.
    Willeit, Peter
    et al.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England.;Med Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria..
    Thompson, Simon G.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England..
    Agewall, Stefan
    Univ Oslo, Inst Clin Sci, N-0316 Oslo, Norway.;Univ Oslo, Ulleval Hosp, Dept Cardiol, N-0316 Oslo, Norway..
    Bergstrom, Goran
    Univ Gothenburg, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden..
    Bickel, Horst
    Tech Univ Munich, Univ Hosp, Dept Psychiat & Psychotherapy, D-80290 Munich, Germany..
    Catapano, Alberico L.
    Univ Milan, Dept Pharmacol Sci, Milan, Italy.;IRCSS Multimed Sesto S Giovanni, Milan, Italy..
    Chien, Kuo-Liong
    Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei 10764, Taiwan.;Natl Taiwan Univ, Dept Internal Med, Taipei 10764, Taiwan..
    de Groot, Eric
    Acad Med Ctr, Cardiol & Thorac Surg & Imagelabonline & Cardiova, Amsterdam, Netherlands..
    Empana, Jean-Philippe
    Univ Paris 05, INSERM, U970, Paris, France..
    Etgen, Thorleif
    Klinikum Traunstein, Kliniken Sudostbayern, Dept Neurol, Traunstein, Germany..
    Franco, Oscar H.
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
    Iglseder, Bernhard
    Paracelsus Med Univ, Dept Geriatr Med, Salzburg, Austria.;Gemeinnutzige Salzburger Landeskliniken Betriebsg, Christian Doppler Klin, Salzburg, Austria..
    Johnsen, Stein H.
    Univ Hosp Northern Norway, Dept Neurol & Neurophysiol, Tromso, Norway.;Univ Tromso, Dept Clin Med, Tromso, Norway..
    Kavousi, Maryam
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Liu, Jing
    Beijing Inst Heart Lung & Blood Vessel Dis, Dept Epidemiol, Beijing, Peoples R China..
    Mathiesen, Ellisiv B.
    Univ Hosp Northern Norway, Dept Neurol & Neurophysiol, Tromso, Norway.;Univ Tromso, Dept Clin Med, Tromso, Norway..
    Norata, Giuseppe D.
    Univ Milan, Dept Pharmacol Sci, Cinisello Balsamo, Italy.;Bassini Hosp, SISA Ctr Study Atherosclerosis, Cinisello Balsamo, Italy..
    Olsen, Michael H.
    Odense Univ Hosp, Ctr Individualized Med Arterial Dis, Dept Endocrinol, Odense, Denmark..
    Papagianni, Aikaterini
    Aristotle Univ Thessaloniki, Hippokrat Gen Hosp, Dept Nephrol, Thessaloniki, Greece..
    Poppert, Holger
    Tech Univ Munich, Univ Hosp, Dept Neurol, D-80290 Munich, Germany..
    Price, Jackie F.
    Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9YL, Midlothian, Scotland..
    Sacco, Ralph L.
    Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA..
    Yanez, David N.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA..
    Zhao, Dong
    Beijing Inst Heart Lung & Blood Vessel Dis, Dept Epidemiol, Beijing, Peoples R China..
    Schminke, Ulf
    Greifswald Univ Clin, Dept Neurol, Greifswald, Germany..
    Buelbuel, Alpaslan
    Univ Hosp Frankfurt, Dept Neurol, Frankfurt, Germany..
    Polak, Joseph F.
    Tufts Univ, Sch Med, Tufts Med Ctr, Boston, MA 02111 USA..
    Sitzer, Matthias
    Univ Hosp Frankfurt, Dept Neurol, Frankfurt, Germany.;Klinikum Herford, Dept Neurol, Herford, Germany..
    Hofman, Albert
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA..
    Grigore, Liliana
    Univ Milan, Dept Pharmacol Sci, Cinisello Balsamo, Italy.;Bassini Hosp, SISA Ctr Study Atherosclerosis, Cinisello Balsamo, Italy..
    Doerr, Marcus
    Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany.;German Ctr Cardiovasc Res DZHK, Halle, Germany..
    Su, Ta-Chen
    Natl Taiwan Univ, Dept Internal Med, Taipei 10764, Taiwan..
    Ducimetiere, Pierre
    Univ Paris 11, Le Kremlin Bicetre, France..
    Xie, Wuxiang
    Beijing Inst Heart Lung & Blood Vessel Dis, Dept Epidemiol, Beijing, Peoples R China..
    Ronkainen, Kimmo
    Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland..
    Kiechl, Stefan
    Med Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria..
    Rundek, Tatjana
    Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA..
    Robertson, Christine
    Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9YL, Midlothian, Scotland..
    Fagerberg, Bjorn
    Univ Gothenburg, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden..
    Bokemark, Lena
    Univ Gothenburg, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden..
    Steinmetz, Helmuth
    Univ Hosp Frankfurt, Dept Neurol, Frankfurt, Germany..
    Ikram, M. Arfan
    Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
    Voelzke, Henry
    Inst Community Med, SHIP Clin Epidemiol Res, Greifswald, Germany..
    Lin, Hung-Ju
    Natl Taiwan Univ, Dept Internal Med, Taipei 10764, Taiwan.;Natl Taiwan Univ Hosp, Hlth Management Ctr, Taipei, Taiwan..
    Plichart, Matthieu
    Univ Paris 05, INSERM, U970, Paris, France.;Broca Hosp, Gerontol Dept, Paris, France..
    Tuomainen, Tomi-Pekka
    Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland..
    Desvarieux, Moise
    Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.;Ecole Hautes Etudes Sante Publ, Paris, France.;INSERM, U738, Paris, France..
    McLachlan, Stela
    Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9YL, Midlothian, Scotland..
    Schmidt, Caroline
    Univ Gothenburg, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden..
    Kauhanen, Jussi
    Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland..
    Willeit, Johann
    Med Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria..
    Lorenz, Matthias W.
    Univ Hosp Frankfurt, Dept Neurol, Frankfurt, Germany..
    Sander, Dirk
    Benedictus Krankenhaus Tutzing & Feldafing, Dept Neurol, Tutzing, Germany.;Tech Univ Munich, D-80290 Munich, Germany..
    Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration2016In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 23, no 2, p. 194-205Article in journal (Refereed)
    Abstract [en]

    BackgroundLarge-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT) in the general population. MethodsInformation on high-sensitivity C-reactive protein, fibrinogen, leucocyte count and CCA-IMT was available in 20 prospective cohort studies of the PROG-IMT collaboration involving 49,097 participants free of pre-existing cardiovascular disease. Estimates of associations were calculated within each study and then combined using random-effects meta-analyses. ResultsMean baseline CCA-IMT amounted to 0.74mm (SD=0.18) and mean CCA-IMT progression over a mean of 3.9 years to 0.011mm/year (SD=0.039). Cross-sectional analyses showed positive linear associations between inflammatory markers and baseline CCA-IMT. After adjustment for traditional cardiovascular risk factors, mean differences in baseline CCA-IMT per one-SD higher inflammatory marker were: 0.0082mm for high-sensitivity C-reactive protein (p<0.001); 0.0072mm for fibrinogen (p<0.001); and 0.0025mm for leucocyte count (p=0.033). Inflammatory load', defined as the number of elevated inflammatory markers (i.e. in upper two quintiles), showed a positive linear association with baseline CCA-IMT (p<0.001). Longitudinal associations of baseline inflammatory markers and changes therein with CCA-IMT progression were null or at most weak. Participants with the highest inflammatory load' had a greater CCA-IMT progression (p=0.015). ConclusionInflammation was independently associated with CCA-IMT cross-sectionally. The lack of clear associations with CCA-IMT progression may be explained by imprecision in its assessment within a limited time period. Our findings for inflammatory load' suggest important combined effects of the three inflammatory markers on early atherosclerosis.

  • 473. Willer, Cristen J.
    et al.
    Schmidt, Ellen M.
    Sengupta, Sebanti
    Peloso, Gina M.
    Gustafsson, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Kanoni, Stavroula
    Ganna, Andrea
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Chen, Jin
    Buchkovich, Martin L.
    Mora, Samia
    Beckmann, Jacques S.
    Bragg-Gresham, Jennifer L.
    Chang, Hsing-Yi
    Demirkan, Ayse
    Den Hertog, Heleen M.
    Do, Ron
    Donnelly, Louise A.
    Ehret, Georg B.
    Esko, Tonu
    Feitosa, Mary F.
    Ferreira, Teresa
    Fischer, Krista
    Fontanillas, Pierre
    Fraser, Ross M.
    Freitag, Daniel F.
    Gurdasani, Deepti
    Heikkila, Kauko
    Hyppoenen, Elina
    Isaacs, Aaron
    Jackson, Anne U.
    Johansson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Johnson, Toby
    Kaakinen, Marika
    Kettunen, Johannes
    Kleber, Marcus E.
    Li, Xiaohui
    Luan, Jian'an
    Lyytikainen, Leo-Pekka
    Magnusson, Patrik K. E.
    Mangino, Massimo
    Mihailov, Evelin
    Montasser, May E.
    Mueller-Nurasyid, Martina
    Nolte, Ilja M.
    O'Connell, Jeffrey R.
    Palmer, Cameron D.
    Perola, Markus
    Petersen, Ann-Kristin
    Sanna, Serena
    Saxena, Richa
    Service, Susan K.
    Shah, Sonia
    Shungin, Dmitry
    Sidore, Carlo
    Song, Ci
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Strawbridge, Rona J.
    Surakka, Ida
    Tanaka, Toshiko
    Teslovich, Tanya M.
    Thorleifsson, Gudmar
    Van den Herik, Evita G.
    Voight, Benjamin F.
    Volcik, Kelly A.
    Waite, Lindsay L.
    Wong, Andrew
    Wu, Ying
    Zhang, Weihua
    Absher, Devin
    Asiki, Gershim
    Barroso, Ines
    Been, Latonya F.
    Bolton, Jennifer L.
    Bonnycastle, Lori L.
    Brambilla, Paolo
    Burnett, Mary S.
    Cesana, Giancarlo
    Dimitriou, Maria
    Doney, Alex S. F.
    Doering, Angela
    Elliott, Paul
    Epstein, Stephen E.
    Eyjolfsson, Gudmundur Ingi
    Gigante, Bruna
    Goodarzi, Mark O.
    Grallert, Harald
    Gravito, Martha L.
    Groves, Christopher J.
    Hallmans, Goran
    Hartikainen, Anna-Liisa
    Hayward, Caroline
    Hernandez, Dena
    Hicks, Andrew A.
    Holm, Hilma
    Hung, Yi-Jen
    Illig, Thomas
    Jones, Michelle R.
    Kaleebu, Pontiano
    Kastelein, John J. P.
    Khaw, Kay-Tee
    Kim, Eric
    Klopp, Norman
    Komulainen, Pirjo
    Kumari, Meena
    Langenberg, Claudia
    Lehtimaki, Terho
    Lin, Shih-Yi
    Lindstrom, Jaana
    Loos, Ruth J. F.
    Mach, Francois
    McArdle, Wendy L.
    Meisinger, Christa
    Mitchell, Braxton D.
    Mueller, Gabrielle
    Nagaraja, Ramaiah
    Narisu, Narisu
    Nieminen, Tuomo V. M.
    Nsubuga, Rebecca N.
    Olafsson, Isleifur
    Ong, Ken K.
    Palotie, Aarno
    Papamarkou, Theodore
    Pomilla, Cristina
    Pouta, Anneli
    Rader, Daniel J.
    Reilly, Muredach P.
    Ridker, Paul M.
    Rivadeneira, Fernando
    Rudan, Igor
    Ruokonen, Aimo
    Samani, Nilesh
    Scharnagl, Hubert
    Seeley, Janet
    Silander, Kaisa
    Stancakova, Alena
    Stirrups, Kathleen
    Swift, Amy J.
    Tiret, Laurence
    Uitterlinden, Andre G.
    van Pelt, L. Joost
    Vedantam, Sailaja
    Wainwright, Nicholas
    Wijmenga, Cisca
    Wild, Sarah H.
    Willemsen, Gonneke
    Wilsgaard, Tom
    Wilson, James F.
    Young, Elizabeth H.
    Zhao, Jing Hua
    Adair, Linda S.
    Arveiler, Dominique
    Assimes, Themistocles L.
    Bandinelli, Stefania
    Bennett, Franklyn
    Bochud, Murielle
    Boehm, Bernhard O.
    Boomsma, Dorret I.
    Borecki, Ingrid B.
    Bornstein, Stefan R.
    Bovet, Pascal
    Burnier, Michel
    Campbell, Harry
    Chakravarti, Aravinda
    Chambers, John C.
    Chen, Yii-Der Ida
    Collins, Francis S.
    Cooper, Richard S.
    Danesh, John
    Dedoussis, George
    de Faire, Ulf
    Feranil, Alan B.
    Ferrieres, Jean
    Ferrucci, Luigi
    Freimer, Nelson B.
    Gieger, Christian
    Groop, Leif C.
    Gudnason, Vilmundur
    Gyllensten, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics.
    Hamsten, Anders
    Harris, Tamara B.
    Hingorani, Aroon
    Hirschhorn, Joel N.
    Hofman, Albert
    Hovingh, G. Kees
    Hsiung, Chao Agnes
    Humphries, Steve E.
    Hunt, Steven C.
    Hveem, Kristian
    Iribarren, Carlos
    Jarvelin, Marjo-Riitta
    Jula, Antti
    Kahonen, Mika
    Kaprio, Jaakko
    Kesaniemi, Antero
    Kivimaki, Mika
    Kooner, Jaspal S.
    Koudstaal, Peter J.
    Krauss, Ronald M.
    Kuh, Diana
    Kuusisto, Johanna
    Kyvik, Kirsten O.
    Laakso, Markku
    Lakka, Timo A.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Lindgren, Cecilia M.
    Martin, Nicholas G.
    Maerz, Winfried
    McCarthy, Mark I.
    McKenzie, Colin A.
    Meneton, Pierre
    Metspalu, Andres
    Moilanen, Leena
    Morris, Andrew D.
    Munroe, Patricia B.
    Njolstad, Inger
    Pedersen, Nancy L.
    Power, Chris
    Pramstaller, Peter P.
    Price, Jackie F.
    Psaty, Bruce M.
    Quertermous, Thomas
    Rauramaa, Rainer
    Saleheen, Danish
    Salomaa, Veikko
    Sanghera, Dharambir K.
    Saramies, Jouko
    Schwarz, Peter E. H.
    Sheu, Wayne H-H
    Shuldiner, Alan R.
    Siegbahn, Agneta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Coagulation and inflammation science.
    Spector, Tim D.
    Stefansson, Kari
    Strachan, David P.
    Tayo, Bamidele O.
    Tremoli, Elena
    Tuomilehto, Jaakko
    Uusitupa, Matti
    van Duijn, Cornelia M.
    Vollenweider, Peter
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Wareham, Nicholas J.
    Whitfield, John B.
    Wolffenbuttel, Bruce H. R.
    Ordovas, Jose M.
    Boerwinkle, Eric
    Palmer, Colin N. A.
    Thorsteinsdottir, Unnur
    Chasman, Daniel I.
    Rotter, Jerome I.
    Franks, Paul W.
    Ripatti, Samuli
    Cupples, L. Adrienne
    Sandhu, Manjinder S.
    Rich, Stephen S.
    Boehnke, Michael
    Deloukas, Panos
    Kathiresan, Sekar
    Mohlke, Karen L.
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Abecasis, Goncalo R.
    Discovery and refinement of loci associated with lipid levels2013In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 45, no 11, p. 1274-1283Article in journal (Refereed)
    Abstract [en]

    Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

  • 474.
    Winkler, Thomas W.
    et al.
    Univ Regensburg, Inst Epidemiol & Prevent Med, Dept Genet Epidemiol, D-93053 Regensburg, Germany..
    Justice, Anne E.
    Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA..
    Graff, Mariaelisa
    Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA..
    Barata, Llilda
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA..
    Feitosa, Mary F.
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA..
    Chu, Su
    Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    Czajkowski, Jacek
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA..
    Esko, Tonu
    MIT, Broad Inst, Cambridge, MA 02139 USA.;Harvard Univ, Cambridge, MA 02138 USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Div Genet, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA..
    Fall, Tove
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Kilpelainen, Tuomas O.
    Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark.;Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England..
    Lu, Yingchang
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA..
    Magi, Reedik
    Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Mihailov, Evelin
    Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia..
    Pers, Tune H.
    Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Div Genet, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA USA..
    Rueeger, Sina
    Swiss Inst Bioinformat, Lausanne, Switzerland.;Univ Hosp Lausanne CHUV, Inst Social & Prevent Med, Lausanne, Switzerland..
    Teumer, Alexander
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany.;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany..
    Ehret, Georg B.
    Univ Hosp Geneva, Dept Specialties Internal Med, Geneva, Switzerland.;Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Baltimore, MD USA..
    Ferreira, Teresa
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Heard-Costa, Nancy L.
    Boston Univ, Sch Med, Dept Neurol, Boston, MA 02215 USA.;NHLBI, Framingham Heart Study, Framingham, MA USA..
    Karjalainen, Juha
    Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands..
    Lagou, Vasiliki
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England..
    Mahajan, Anubha
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Neinast, Michael D.
    Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA..
    Prokopenko, Inga
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Hammersmith Hosp, London, England.;Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Genom Common Dis, London, England..
    Simino, Jeannette
    Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA..
    Teslovich, Tanya M.
    Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    Jansen, Rick
    Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands..
    Westra, Harm-Jan
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Rheumatol, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA.;Partners Ctr Personalized Genet Med, Boston, MA USA..
    White, Charles C.
    Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA..
    Absher, Devin
    HudsonAlpha Inst Biotechnol, Huntsville, AL USA..
    Ahluwalia, Tarunveer S.
    Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark.;Steno Diabet Ctr A S, Gentofte, Denmark.;Univ Copenhagen, Herlev & Gentofte Hosp, COPSAC, Copenhagen, Denmark..
    Ahmad, Shafqat
    Skane Univ Hosp Malmo, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden..
    Albrecht, Eva
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany..
    Alves, Alexessander Couto
    Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, MRC Hlth Protect Agcy HPA Ctr Environm & Hlth, Dept Epidemiol & Biostat, London, England..
    Bragg-Gresham, Jennifer L.
    Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    de Craen, Anton J. M.
    Leiden Univ Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands..
    Bis, Joshua C.
    Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Dept Med, Seattle, WA 98195 USA..
    Bonnefond, Amelie
    CNRS, UMR 8199, Lille, France.;European Genom Inst Diabet, Lille, France.;Univ Lille 2, Lille, France..
    Boucher, Gabrielle
    Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada..
    Cadby, Gemma
    Univ Western Australia, Ctr Genet Origins Hlth & Dis, Crawley, WA, Australia..
    Cheng, Yu-Ching
    VA Maryland Hlth Care Syst, Baltimore, MD USA.;Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA..
    Chiang, Charleston W. K.
    Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA USA..
    Delgado, Graciela
    Heidelberg Univ, Mannheim Med Fac, Dept Med 5, Mannheim, Germany..
    Demirkan, Ayse
    Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands..
    Dueker, Nicole
    Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA..
    Eklund, Niina
    Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Natl Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland.;Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland..
    Eiriksdottir, Gudny
    Iceland Heart Assoc, Kopavogur, Iceland..
    Eriksson, Joel
    Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med,Dept Internal Med & Clin Nutr, Gothenburg, Sweden..
    Feenstra, Bjarke
    Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark..
    Fischer, Krista
    Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia..
    Frau, Francesca
    Univ Milan, Dept Hlth Sci, Milan, Italy.;Filarete Fdn, Genom & Bioinformat Unit, Milan, Italy..
    Galesloot, Tessel E.
    Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Dept Hlth Evidence, NL-6525 ED Nijmegen, Netherlands..
    Geller, Frank
    Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark..
    Goel, Anuj
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovac Med, Oxford, England..
    Gorski, Mathias
    Univ Regensburg, Inst Epidemiol & Prevent Med, Dept Genet Epidemiol, D-93053 Regensburg, Germany.;Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany..
    Grammer, Tanja B.
    Heidelberg Univ, Mannheim Med Fac, Dept Med 5, Mannheim, Germany..
    Gustafsson, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Haitjema, Saskia
    UMCU, Expt Cardiol & Lab Clin Chem, Utrecht, Netherlands..
    Hottenga, Jouke-Jan
    Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands..
    Huffman, Jennifer E.
    NHLBI, Framingham Heart Study, Framingham, MA USA.;Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Jackson, Anne U.
    Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    Jacobs, Kevin B.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.;NCI, Core Genotyping Facil, SAIC Frederick Inc, Frederick, MD 21701 USA..
    Johansson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Kaakinen, Marika
    Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, MRC Hlth Protect Agcy HPA Ctr Environm & Hlth, Dept Epidemiol & Biostat, London, England.;Univ Oulu, Inst Hlth Sci, Oulu, Finland..
    Kleber, Marcus E.
    Heidelberg Univ, Mannheim Med Fac, Dept Med 5, Mannheim, Germany..
    Lahti, Jari
    Folkhalsan Res Ctr, Helsinki, Finland.;Univ Helsinki, Inst Behav Sci, Helsinki, Finland..
    Leach, Irene Mateo
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands..
    Lehne, Benjamin
    Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, London, England..
    Liu, Youfang
    Univ N Carolina Chapel Hill, Thurston Arthrit Res Ctr, Chaper Hill, NC USA..
    Lo, Ken Sin
    Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada..
    Lorentzon, Mattias
    Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med,Dept Internal Med & Clin Nutr, Gothenburg, Sweden..
    Luan, Jian'an
    Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England..
    Madden, Pamela A. F.
    Washington Univ, Sch Med, St Louis, MO USA..
    Mangino, Massimo
    Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England..
    McKnight, Barbara
    Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Biostat & Biomath, Seattle, WA 98104 USA.;Univ Washington, Dept Biostat, Seattle, WA 98195 USA..
    Medina-Gomez, Carolina
    NCHA, NGI, Leiden, Netherlands.;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands..
    Monda, Keri L.
    Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.;Amgen Inc, Ctr Observat Res, Thousand Oaks, CA 91320 USA..
    Montasser, May E.
    Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr,Program Personalized, Baltimore, MD 21201 USA..
    Mueller, Gabriele
    Univ Dresden, Med Fac Carl Gustav Carus, Ctr Evidence Based Healthcare, Dresden, Germany..
    Mueller-Nurasyid, Martina
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.;Univ Munich, Univ Hosp Grosshadern, Dept Med 1, D-81377 Munich, Germany.;Univ Munich, Inst Med Informat Biometry & Epidemiol, Chair Genet Epidemiol, D-81377 Munich, Germany.;Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany..
    Nolte, Ilja M.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Panoutsopoulou, Kalliope
    Wellcome Trust Sanger Inst, Human Genet, Cambridge, England..
    Pascoe, Laura
    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle, NSW, Australia..
    Paternoster, Lavinia
    Univ Bristol, Sch Social & Community Med, MRC Integrat Epidemiol Unit, Bristol, Avon, England..
    Rayner, Nigel W.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Wellcome Trust Sanger Inst, Human Genet, Cambridge, England..
    Renstrom, Frida
    Skane Univ Hosp Malmo, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden..
    Rizzi, Federica
    Univ Milan, Dept Hlth Sci, Milan, Italy.;Filarete Fdn, Genom & Bioinformat Unit, Milan, Italy..
    Rose, Lynda M.
    Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA..
    Ryan, Kathy A.
    Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr,Program Personalized, Baltimore, MD 21201 USA..
    Salo, Perttu
    Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Natl Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland..
    Sanna, Serena
    CNR, Ist Ric Genet & Biomed, Monserrato, Italy..
    Scharnagl, Hubert
    Med Univ Graz, Inst Clin Med, Graz, Austria.;Med Univ Graz, Chem Lab Diagnost, Graz, Austria..
    Shi, Jianxin
    NCI, Bethesda, MD 20892 USA..
    Smith, Albert Vernon
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Southam, Lorraine
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Wellcome Trust Sanger Inst, Human Genet, Cambridge, England..
    Stancakova, Alena
    Univ Eastern Finland, Dept Med, Kuopio, Finland.;Kuopio Univ Hosp, SF-70210 Kuopio, Finland..
    Steinthorsdottir, Valgerdur
    Amgen Inc, deCODE Genet, Reykjavik, Iceland..
    Strawbridge, Rona J.
    Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden..
    Sung, Yun Ju
    Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA..
    Tachmazidou, Ioanna
    Wellcome Trust Sanger Inst, Human Genet, Cambridge, England..
    Tanaka, Toshiko
    NIA, Translat Gerontol Branch, Baltimore, MD 21224 USA..
    Thorleifsson, Gudmar
    Amgen Inc, deCODE Genet, Reykjavik, Iceland..
    Trompet, Stella
    Leiden Univ Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands.;Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands..
    Pervjakova, Natalia
    Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Natl Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland.;Univ Tartu, Inst Cell & Mol Biol, Dept Biotechnol, EE-50090 Tartu, Estonia.;Univ Helsinki, Helsinki, Finland..
    Tyrer, Jonathan P.
    Univ Cambridge, Dept Oncol, Cambridge, England..
    Vandenput, Liesbeth
    Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med,Dept Internal Med & Clin Nutr, Gothenburg, Sweden..
    van der Laan, Sander W.
    UMCU, Expt Cardiol & Lab Clin Chem, Utrecht, Netherlands..
    van der Velde, Nathalie
    Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.;Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Geriatr Med Sect, NL-1105 AZ Amsterdam, Netherlands..
    van Setten, Jessica
    Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands..
    van Vliet-Ostaptchouk, Jana V.
    Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands..
    Verweij, Niek
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands..
    Vlachopoulou, Efthymia
    Univ Helsinki, Transplantat Lab, Haartman Inst, Helsinki, Finland..
    Waite, Lindsay L.
    HudsonAlpha Inst Biotechnol, Huntsville, AL USA..
    Wang, Sophie R.
    Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Div Genet, Boston, MA USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Program Genom, Boston, MA USA..
    Wang, Zhaoming
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.;NCI, Core Genotyping Facil, SAIC Frederick Inc, Frederick, MD 21701 USA..
    Wild, Sarah H.
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland..
    Willenborg, Christina
    Hamburg Kiel Lubeck, DZHK German Ctr Cardiovasc Res, Lubeck, Germany.;Univ Lubeck, Inst Integrat & Expt Genom, Lubeck, Germany..
    Wilson, James F.
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Wong, Andrew
    MRC Unit Lifelong Hlth & Ageing UCL, London, England..
    Yang, Jian
    Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia..
    Yengo, Loic
    CNRS, UMR 8199, Lille, France.;European Genom Inst Diabet, Lille, France.;Univ Lille 2, Lille, France..
    Yerges-Armstrong, Laura M.
    Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr,Program Personalized, Baltimore, MD 21201 USA..
    Yu, Lei
    Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA..
    Zhang, Weihua
    Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, London, England.;Ealing Hosp NHS Trust, Southall, Middx, England..
    Zhao, Jing Hua
    Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England..
    Andersson, Ehm A.
    Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark..
    Bakker, Stephan J. L.
    Univ Groningen, Univ Med Ctr Groningen, Dept Med, Groningen, Netherlands..
    Baldassarre, Damiano
    IRCCS, Ctr Cardiol Monzino, Milan, Italy.;Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy..
    Banasik, Karina
    Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark..
    Barcella, Matteo
    Univ Milan, Dept Hlth Sci, Milan, Italy..
    Barlassina, Cristina
    Univ Milan, Dept Hlth Sci, Milan, Italy..
    Bellis, Claire
    Texas Biomed Res Inst, Dept Genet, San Antonio, TX USA.;Queensland Univ Technol, Inst Hlth & Biomed Innovat, Genom Res Ctr, Brisbane, Qld 4001, Australia..
    Benaglio, Paola
    Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA.;Univ Lausanne, Dept Med Genet, Lausanne, Switzerland..
    Blangero, John
    Texas Biomed Res Inst, Dept Genet, San Antonio, TX USA..
    Blueher, Matthias
    Univ Leipzig, IFB Adipos Dis, D-04109 Leipzig, Germany.;Univ Leipzig, Dept Med, D-04109 Leipzig, Germany..
    Bonnet, Fabrice
    Univ Rennes 1, Rennes, France..
    Bonnycastle, Lori L.
    NHGRI, Med Genom & Metab Genet Branch, NIH, Bethesda, MD 20892 USA..
    Boyd, Heather A.
    Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark..
    Bruinenberg, Marcel
    Univ Groningen, Univ Med Ctr Groningen, LifeLines Cohort Study, Groningen, Netherlands..
    Buchman, Aron S.
    Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA..
    Campbell, Harry
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    Chen, Yii-Der Ida
    Univ Calif Los Angeles, Med Ctr, Los Angeles BioMed Res Inst Harbor, Torrance, CA 90509 USA..
    Chines, Peter S.
    NHGRI, Med Genom & Metab Genet Branch, NIH, Bethesda, MD 20892 USA..
    Claudi-Boehm, Simone
    Univ Ulm, Med Ctr, Dept Internal Med 1, D-89069 Ulm, Germany..
    Cole, John
    VA Maryland Hlth Care Syst, Baltimore, MD USA.;Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA..
    Collins, Francis S.
    NHGRI, Med Genom & Metab Genet Branch, NIH, Bethesda, MD 20892 USA..
    de Geus, Eco J. C.
    Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands..
    de Groot, Lisette C. P. G. M.
    Wageningen Univ, Dept Human Nutr, NL-6700 AP Wageningen, Netherlands..
    Dimitriou, Maria
    Wellcome Trust Sanger Inst, Human Genet, Cambridge, England.;Harokopio Univ, Dept Dietet Nutr, Athens, Greece..
    Duan, Jubao
    NorthShore Univ HealthSyst, Evanston, IL USA.;Univ Chicago, Chicago, IL 60637 USA..
    Enroth, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Eury, Elodie
    CNRS, UMR 8199, Lille, France.;European Genom Inst Diabet, Lille, France.;Univ Lille 2, Lille, France..
    Farmaki, Aliki-Eleni
    Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece..
    Forouhi, Nita G.
    Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England..
    Friedrich, Nele
    Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany..
    Gejman, Pablo V.
    NorthShore Univ HealthSyst, Evanston, IL USA.;Univ Chicago, Chicago, IL 60637 USA..
    Gigante, Bruna
    Karolinska Inst, Inst Environm Med, Div Cardiovasc Epidemiol, Stockholm, Sweden..
    Glorioso, Nicola
    AOU Univ Sassari, Hypertens & Related Dis Ctr, Sassari, Italy..
    Go, Alan S.
    Kaiser Permanente, Div Res, Oakland, CA USA..
    Gottesman, Omri
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA..
    Graessler, Juergen
    Univ Dresden, Dept Med Pathobiochem 3, Dresden, Germany..
    Grallert, Harald
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;German Ctr Diabet Res DZD, Neuherberg, Germany..
    Grarup, Niels
    Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark..
    Gu, Yu-Mei
    Univ Leuven, KU Leuven Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium..
    Broer, Linda
    Erasmus MC, Dept Internal Med, Rotterdam, Netherlands..
    Ham, Annelies C.
    Erasmus MC, Dept Internal Med, Rotterdam, Netherlands..
    Hansen, Torben
    Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark.;Univ Southern Denmark, Fac Hlth Sci, Odense, Denmark..
    Harris, Tamara B.
    NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA.;NIA, NIH, Bethesda, MD 20892 USA..
    Hartman, Catharina A.
    Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands..
    Hassinen, Maija
    Kuopio Res Inst Exercise Med, Kuopio, Finland..
    Hastie, Nicholas
    Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Hattersley, Andrew T.
    Univ Exeter, Inst Biomed & Clin Sci, Exeter, Devon, England..
    Heath, Andrew C.
    Washington Univ, Sch Med, St Louis, MO USA..
    Henders, Anjali K.
    QIMR Bergofer Med Res Inst, Brisbane, Qld, Australia..
    Hernandez, Dena
    NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA..
    Hillege, Hans
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands..
    Holmen, Oddgeir
    Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, N-7034 Trondheim, Norway..
    Hovingh, Kees G.
    Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands..
    Hui, Jennie
    Pathwest Lab Med Western Australia, Nedlands, WA, Australia.;Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia.;Univ Western Australia, Sch Populat Hlth, Nedlands, WA 6009, Australia..
    Husemoen, Lise L.
    Glostrup Cty Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark..
    Hutri-Kahonen, Nina
    Univ Tampere, Sch Med, Dept Pediat, FIN-33101 Tampere, Finland.;Tampere Univ Hosp, Dept Pediat, Tampere, Finland..
    Hysi, Pirro G.
    Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England..
    Illig, Thomas
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;Hannover Med Sch, Hannover Unified Biobank, Hannover, Germany.;Hannover Med Sch, Inst Human Genet, Hannover, NH, Germany..
    De Jager, Philip L.
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Neurol, Program Translat NeuroPsychiat Genom, Boston, MA 02115 USA..
    Jalilzadeh, Shapour
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovac Med, Oxford, England..
    Jorgensen, Torben
    Glostrup Cty Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.;Aalborg Univ, Fac Med, Aalborg, Denmark..
    Jukema, J. Wouter
    Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands.;Interuniv Cardiol Inst Netherlands, Utrecht, Netherlands..
    Juonala, Markus
    Turku Univ Hosp, Div Med, FIN-20520 Turku, Finland.;Murdoch Childrens Res Inst, Parkville, Vic, Australia.;Univ Turku, Dept Med, Turku, Finland..
    Kanoni, Stavroula
    Wellcome Trust Sanger Inst, Human Genet, Cambridge, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England..
    Karaleftheri, Maria
    Echinos Med Ctr, Echinos, Greece..
    Khaw, Kay Tee
    Addenbrookes Hosp, Clin Gerontol Unit, Cambridge, England..
    Kinnunen, Leena
    Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland..
    Kittner, Steven J.
    VA Maryland Hlth Care Syst, Baltimore, MD USA.;Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA..
    Koenig, Wolfgang
    Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, D-89069 Ulm, Germany..
    Kolcic, Ivana
    Univ Split, Fac Med, Dept Publ Hlth, Split, Croatia..
    Kovacs, Peter
    Univ Leipzig, IFB Adipos Dis, D-04109 Leipzig, Germany..
    Krarup, Nikolaj T.
    Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark..
    Kratzer, Wolfgang
    Univ Ulm, Med Ctr, Dept Internal Med 1, D-89069 Ulm, Germany..
    Krueger, Janine
    Univ Med Greifswald, Dept Med A, Greifswald, Germany..
    Kuh, Diana
    MRC Unit Lifelong Hlth & Ageing UCL, London, England..
    Kumari, Meena
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Kyriakou, Theodosios
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovac Med, Oxford, England..
    Langenberg, Claudia
    Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.;UCL, Dept Epidemiol & Publ Hlth, London, England..
    Lannfelt, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Lanzani, Chiara
    Univ Vita Salute San Raffaele, Chair Nephrol, Segrate, Milan, Italy.;IRCCS San Raffaele Sci Inst, Genom Renal Dis & Hypertens Unit, Segrate, Milan, Italy..
    Lotay, Vaneet
    Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada..
    Launer, Lenore J.
    NIA, NIH, Bethesda, MD 20892 USA..
    Leander, Karin
    Karolinska Inst, Inst Environm Med, Div Cardiovasc Epidemiol, Stockholm, Sweden..
    Lindstrom, Jaana
    Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland..
    Linneberg, Allan
    Glostrup Cty Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.;Rigshosp, Dept Clin Expt Res, Glostrup, Denmark..
    Liu, Yan-Ping
    Univ Leuven, KU Leuven Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium..
    Lobbens, Stephane
    CNRS, UMR 8199, Lille, France.;European Genom Inst Diabet, Lille, France..
    Luben, Robert
    Strangeways Res Lab Worts Causeway, Cambridge, England..
    Lyssenko, Valeriya
    Steno Diabet Ctr A S, Gentofte, Denmark.;Lund Univ, Ctr Diabet, Malmo, Sweden.;Lund Univ, Dept Clin Sci, Diabet & Endocrinol Unit, Malmo, Sweden..
    Mannisto, Satu
    Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland..
    Magnusson, Patrik K.
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    McArdle, Wendy L.
    Univ Bristol, Sch Social & Community Med, Bristol, Avon, England..
    Menni, Cristina
    Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England..
    Merger, Sigrun
    Univ Ulm, Med Ctr, Dept Internal Med 1, D-89069 Ulm, Germany..
    Milani, Lili
    Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia..
    Montgomery, Grant W.
    QIMR Bergofer Med Res Inst, Brisbane, Qld, Australia..
    Morris, Andrew P.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool L69 3BX, Merseyside, England..
    Narisu, Narisu
    NHGRI, Med Genom & Metab Genet Branch, NIH, Bethesda, MD 20892 USA..
    Nelis, Mari
    Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia..
    Ong, Ken K.
    Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.;MRC Unit Lifelong Hlth & Ageing UCL, London, England.;Univ Cambridge, Dept Paediat, Cambridge, England..
    Palotie, Aarno
    Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;Wellcome Trust Sanger Inst, Human Genet, Cambridge, England.;Massachusetts Gen Hosp, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.;Metaanal Glucose & Insulin Related Traits Consort, Beijing, Peoples R China..
    Perusse, Louis
    Univ Laval, Dept Kinesiol, Quebec City, PQ, Canada.;Univ Laval, Inst Nutr & Funct Foods, Quebec City, PQ, Canada..
    Pichler, Irene
    European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.;Med Univ Lubeck, Affiliated Inst, D-23538 Lubeck, Germany..
    Pilia, Maria G.
    CNR, Ist Ric Genet & Biomed, Monserrato, Italy..
    Pouta, Anneli
    Natl Inst Hlth & Welf, Dept Children Young People & Families, Helsinki, Finland.;Oulu Univ Hosp, Med Res Ctr, Dept Obstet & Gynecol, Oulu, Finland.;Univ Oulu, Oulu, Finland..
    Rheinberger, Myriam
    Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany..
    Ribel-Madsen, Rasmus
    Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark..
    Richards, Marcus
    MRC Unit Lifelong Hlth & Ageing UCL, London, England..
    Rice, Kenneth M.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA..
    Rice, Treva K.
    Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA.;Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA..
    Rivolta, Carlo
    Univ Lausanne, Dept Med Genet, Lausanne, Switzerland..
    Salomaa, Veikko
    Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland..
    Sanders, Alan R.
    NorthShore Univ HealthSyst, Evanston, IL USA.;Univ Chicago, Chicago, IL 60637 USA..
    Sarzynski, Mark A.
    Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70808 USA..
    Scholtens, Salome
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Scott, Robert A.
    Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England..
    Scott, William R.
    Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, London, England.;Ealing Hosp NHS Trust, Southall, Middx, England..
    Sebert, Sylvain
    Univ Oulu, Inst Hlth Sci, Oulu, Finland..
    Sengupta, Sebanti
    Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    Sennblad, Bengt
    Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden.;Karolinska Inst, Sci Life Lab, Stockholm, Sweden..
    Seufferlein, Thomas
    Univ Ulm, Med Ctr, Dept Internal Med 1, D-89069 Ulm, Germany..
    Silveira, Angela
    Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden..
    Slagboom, P. Eline
    Leiden Univ Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands..
    Smit, Jan H.
    Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands..
    Sparso, Thomas H.
    Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark..
    Stirrups, Kathleen
    Wellcome Trust Sanger Inst, Human Genet, Cambridge, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England..
    Stolk, Ronald P.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Stringham, Heather M.
    Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    Swertz, Morris A.
    Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands..
    Swift, Amy J.
    NHGRI, Med Genom & Metab Genet Branch, NIH, Bethesda, MD 20892 USA..
    Syvänen, Ann-Christine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
    Tan, Sian-Tsung
    Ealing Hosp NHS Trust, Southall, Middx, England.;Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England..
    Thorand, Barbara
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;German Ctr Diabet Res DZD, Neuherberg, Germany..
    Toenjes, Anke
    Univ Leipzig, Dept Med, D-04109 Leipzig, Germany..
    Tremblay, Angelo
    Univ Laval, Dept Kinesiol, Quebec City, PQ, Canada..
    Tsafantakis, Emmanouil
    Anogia Med Ctr, Anogia, Greece..
    van der Most, Peter J.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Voelker, Uwe
    Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Greifswald, Germany..
    Vohl, Marie-Claude
    Univ Laval, Inst Nutr & Funct Foods, Quebec City, PQ, Canada.;Univ Laval, Sch Nutr, Quebec City, PQ, Canada..
    Vonk, Judith M.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Waldenberger, Melanie
    Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany..
    Walker, Ryan W.
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA..
    Wennauer, Roman
    Univ Ulm, Med Ctr, Dept Clin Chem, D-89069 Ulm, Germany..
    Widen, Elisabeth
    Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland..
    Willemsen, Gonneke
    Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands..
    Wilsgaard, Tom
    Univ Tromso, Fac Hlth Sci, Dept Clin Med, Tromso, Norway.;Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway..
    Wright, Alan F.
    Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Zillikens, M. Carola
    NCHA, NGI, Leiden, Netherlands.;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands..
    van Dijk, Suzanne C.
    Erasmus MC, Dept Internal Med, Rotterdam, Netherlands..
    van Schoor, Natasja M.
    Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands..
    Asselbergs, Folkert W.
    Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.;Netherlands Heart Inst, Interuniv Cardiol Inst Netherlands, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands.;UCL, Inst Cardiovasc Sci, London, England..
    de Bakker, Paul I. W.
    Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands.;Univ Med Ctr, Dept Epidemiol, Utrecht, Netherlands..
    Beckmann, Jacques S.
    Swiss Inst Bioinformat, Lausanne, Switzerland..
    Beilby, John
    Pathwest Lab Med Western Australia, Nedlands, WA, Australia.;Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia..
    Bennett, David A.
    Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA..
    Bergman, Richard N.
    Cedars Sinai Med Ctr, Diabet & Obes Res Inst, Los Angeles, CA 90048 USA..
    Bergmann, Sven
    Swiss Inst Bioinformat, Lausanne, Switzerland.;Univ Lausanne, Dept Med Genet, Lausanne, Switzerland..
    Boeger, Carsten A.
    Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany..
    Boehm, Bernhard O.
    Univ Ulm, Med Ctr, Dept Internal Med 1, D-89069 Ulm, Germany.;Univ London Imperial Coll Sci Technol & Med, London, England.;Lee Kong Chian Sch Med, Singapore, Singapore.;Nanyang Technol Univ, Singapore 639798, Singapore..
    Boerwinkle, Eric
    Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX 77030 USA.;Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Houston, TX 77030 USA..
    Boomsma, Dorret I.
    Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands..
    Bornstein, Stefan R.
    Univ Dresden, Med Fac Carl Gustav Carus, Dept Med 3, Dresden, Germany..
    Bottinger, Erwin P.
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA..
    Bouchard, Claude
    Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70808 USA..
    Chambers, John C.
    Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, London, England.;Ealing Hosp NHS Trust, Southall, Middx, England.;Imperial Coll Healthcare NHS Trust, London, England..
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Biostat & Biomath, Seattle, WA 98104 USA..
    Chasman, Daniel I.
    Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA..
    Cucca, Francesco
    CNR, Ist Ric Genet & Biomed, Monserrato, Italy.;Univ Sassari, I-07100 Sassari, Italy..
    Cusi, Daniele
    Univ Milan, Dept Hlth Sci, Milan, Italy.;Natl Inst Res, Inst Biomed Technol, Segrate, Italy..
    Dedoussis, George
    Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece..
    Erdmann, Jeanette
    Hamburg Kiel Lubeck, DZHK German Ctr Cardiovasc Res, Lubeck, Germany.;Univ Lubeck, Inst Integrat & Expt Genom, Lubeck, Germany..
    Eriksson, Johan G.
    Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Folkhalsan Res Ctr, Helsinki, Finland.;Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland..
    Evans, Denis A.
    Rush Univ, Med Ctr, Rush Inst Healthy Aging, Chicago, IL 60612 USA.;Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA..
    de Faire, Ulf
    Karolinska Inst, Inst Environm Med, Div Cardiovasc Epidemiol, Stockholm, Sweden..
    Farrall, Martin
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovac Med, Oxford, England.;Durrer Ctr Cardiogenet Res, Amsterdam, Netherlands..
    Ferrucci, Luigi
    NIA, Translat Gerontol Branch, Baltimore, MD 21224 USA..
    Ford, Ian
    Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland..
    Franke, Lude
    Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands..
    Franks, Paul W.
    Skane Univ Hosp Malmo, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden.;Umea Univ Hosp, Dept Publ Hlth & Clin Med, Umea, Sweden.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA..
    Froguel, Philippe
    CNRS, UMR 8199, Lille, France.;European Genom Inst Diabet, Lille, France.;Univ Lille 2, Lille, France..
    Gansevoort, Ron T.
    Univ Groningen, Univ Med Ctr Groningen, Dept Med, Groningen, Netherlands..
    Gieger, Christian
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany..
    Gronberg, Henrik
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Gudnason, Vilmundur
    Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Gyllensten, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Hall, Per
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Hamsten, Anders
    Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden.;Karolinska Inst, Dept Med, Stockholm, Sweden..
    van der Harst, Pim
    Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.;Netherlands Heart Inst, Interuniv Cardiol Inst Netherlands, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands..
    Hayward, Caroline
    Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Heliovaara, Markku
    Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland..
    Hengstenberg, Christian
    Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany.;Tech Univ Munich, Deutsch Herzzentrum Munchen, D-80290 Munich, Germany..
    Hicks, Andrew A.
    European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.;Med Univ Lubeck, Affiliated Inst, D-23538 Lubeck, Germany..
    Hingorani, Aroon
    UCL, Inst Cardiovasc Sci, London, England..
    Hofman, Albert
    NCHA, NGI, Leiden, Netherlands.;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
    Hu, Frank
    Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA..
    Huikuri, Heikki V.
    Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.;Univ Oulu, Oulu, Finland..
    Hveem, Kristian
    Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, N-7034 Trondheim, Norway..
    James, Alan L.
    Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, Nedlands, WA 6009, Australia..
    Jordan, Joanne M.
    Univ N Carolina Chapel Hill, Thurston Arthrit Res Ctr, Chaper Hill, NC USA..
    Jula, Antti
    Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland..
    Kaehoenen, Mika
    Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Univ Tampere, Sch Med, Dept Clin Physiol, FIN-33101 Tampere, Finland..
    Kajantie, Eero
    Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland.;Helsinki Univ Hosp, Childrens Hosp, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland..
    Kathiresan, Sekar
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA..
    Kiemeney, Lambertus A. L. M.
    Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Dept Hlth Evidence, NL-6525 ED Nijmegen, Netherlands.;Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Dept Urol, NL-6525 ED Nijmegen, Netherlands..
    Kivimaki, Mika
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Knekt, Paul B.
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Koistinen, Heikki A.
    Natl Inst Hlth & Welf, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.;Helsinki Univ Cent Hosp, Dept Med, Helsinki, Finland.;Abdominal Ctr Endocrinol, Helsinki, Finland.;Minerva Fdn, Helsinki, Finland..
    Kooner, Jaspal S.
    Ealing Hosp NHS Trust, Southall, Middx, England.;Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England.;Imperial Coll Healthcare NHS Trust, London, England..
    Koskinen, Seppo
    Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland..
    Kuusisto, Johanna
    Univ Eastern Finland, Dept Med, Kuopio, Finland.;Kuopio Univ Hosp, SF-70210 Kuopio, Finland..
    Maerz, Winfried
    Heidelberg Univ, Mannheim Med Fac, Dept Med 5, Mannheim, Germany.;Med Univ Graz, Inst Clin Med, Graz, Austria.;Med Univ Graz, Chem Lab Diagnost, Graz, Austria..
    Martin, Nicholas G.
    QIMR Bergofer Med Res Inst, Brisbane, Qld, Australia..
    Laakso, Markku
    Univ Eastern Finland, Dept Med, Kuopio, Finland.;Kuopio Univ Hosp, SF-70210 Kuopio, Finland..
    Lakka, Timo A.
    Kuopio Res Inst Exercise Med, Kuopio, Finland.;Univ Eastern Finland, Inst Biomed, Dept Physiol, Kuopio, Finland..
    Lehtimaki, Terho
    Univ Tampere, Sch Med, Dept Clin Chem, FIN-33101 Tampere, Finland.;Univ Tampere, Dept Clin Chem, Fimlab Labs, FIN-33101 Tampere, Finland.;Univ Tampere, Sch Med, FIN-33101 Tampere, Finland..
    Lettre, Guillaume
    Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.;Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada..
    Levinson, Douglas F.
    Stanford Univ, Stanford, CA 94305 USA..
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Lokki, Marja-Liisa
    Univ Helsinki, Transplantat Lab, Haartman Inst, Helsinki, Finland..
    Mantyselka, Pekka
    Univ Eastern Finland, Sch Med, Inst Publ Hlth & Clin Nutr, Primary Hlth Care Unit, Kuopio, Finland.;Kuopio Univ Hosp, Primary Hlth Care Unit, SF-70210 Kuopio, Finland..
    Melbye, Mads
    Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.;Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA..
    Metspalu, Andres
    Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia..
    Mitchell, Braxton D.
    Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA.;Baltimore Vet Adm Med Ctr, Geriatr Res & Educ Clin Ctr, Baltimore, MD USA..
    Moll, Frans L.
    Univ Med Ctr Utrecht, Dept Surg, Utrecht, Netherlands..
    Murray, Jeffrey C.
    Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA..
    Musk, Arthur W.
    Sir Charles Gairdner Hosp, Dept Resp Med, Nedlands, WA 6009, Australia..
    Nieminen, Markku S.
    Helsinki Univ Cent Hosp, HUCH Heart & Lung Ctr, Div Cardiol, Helsinki, Finland..
    Njolstad, Inger
    Univ Tromso, Fac Hlth Sci, Dept Clin Med, Tromso, Norway.;Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway..
    Ohlsson, Claes
    Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med,Dept Internal Med & Clin Nutr, Gothenburg, Sweden..
    Oldehinkel, Albertine J.
    Univ Groningen, Univ Med Ctr, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands..
    Oostra, Ben A.
    Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands..
    Palmer, Lyle J.
    Univ Adelaide, Sch Publ Hlth, Adelaide, SA, Australia.;Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia..
    Pankow, James S.
    Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA..
    Pasterkamp, Gerard
    UMCU, Expt Cardiol & Lab Clin Chem, Utrecht, Netherlands..
    Pedersen, Nancy L.
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Pedersen, Oluf
    Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark..
    Penninx, Brenda W.
    Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands..
    Perola, Markus
    Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland..
    Peters, Annette
    Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany..
    Polasek, Ozren
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.;Univ Split, Fac Med, Dept Publ Hlth, Split, Croatia..
    Pramstaller, Peter P.
    European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.;Med Univ Lubeck, Affiliated Inst, D-23538 Lubeck, Germany.;Gen Cent Hosp, Dept Neurol, Bolzano, Italy..
    Psaty, Bruce M.
    Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Dept Med, Seattle, WA 98195 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.;Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA.;Grp Hlth Cooperat, Grp Hlth Res Inst, Seatte, WA USA..
    Qi, Lu
    Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA..
    Quertermous, Thomas
    Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA..
    Raitakari, Olli T.
    Turku Univ Hosp, Dept Clin Physiol & Nucl Med, FIN-20520 Turku, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland..
    Rankinen, Tuomo
    Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70808 USA..
    Rauramaa, Rainer
    Kuopio Res Inst Exercise Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland..
    Ridker, Paul M.
    Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA..
    Rioux, John D.
    Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.;Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada..
    Rivadeneira, Fernando
    NCHA, NGI, Leiden, Netherlands.;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands..
    Rotter, Jerome I.
    Univ Calif Los Angeles, Med Ctr, Los Angeles BioMed Res Inst Harbor, Torrance, CA 90509 USA..
    Rudan, Igor
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland..
    den Ruijter, Hester M.
    UMCU, Expt Cardiol & Lab Clin Chem, Utrecht, Netherlands..
    Saltevo, Juha
    Cent Finland Cent Hosp, Dept Med, Jyvaskyla, Finland..
    Sattar, Naveed
    Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland..
    Schunkert, Heribert
    Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany.;Tech Univ Munich, Deutsch Herzzentrum Munchen, D-80290 Munich, Germany..
    Schwarz, Peter E. H.
    Univ Dresden, Med Fac Carl Gustav Carus, Dept Med 3, Dresden, Germany..
    Shuldiner, Alan R.
    Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr,Program Personalized, Baltimore, MD 21201 USA.;Vetrans Adm Med Ctr, Geriatr Res & Educ Clin Ctr, Baltimore, MD USA..
    Sinisalo, Juha
    Helsinki Univ Cent Hosp, HUCH Heart & Lung Ctr, Div Cardiol, Helsinki, Finland..
    Snieder, Harold
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands..
    Sorensen, Thorkild I. A.
    Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark.;Univ Bristol, Sch Social & Community Med, MRC Integrat Epidemiol Unit, Bristol, Avon, England.;Bispebjerg & Frederiksberg Hosp, Inst Prevent Med, Frederiksberg, Denmark..
    Spector, Tim D.
    Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England..
    Staessen, Jan A.
    Univ Leuven, KU Leuven Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium.;Maastricht Univ, R&D VitaK Grp, Maastricht, Netherlands..
    Stefania, Bandinelli
    ASF, Geriatr Unit, Florence, Italy..
    Thorsteinsdottir, Unnur
    Amgen Inc, deCODE Genet, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Stumvoll, Michael
    Univ Leipzig, IFB Adipos Dis, D-04109 Leipzig, Germany.;Univ Leipzig, Dept Med, D-04109 Leipzig, Germany..
    Tardif, Jean-Claude
    Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.;Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada..
    Tremoli, Elena
    IRCCS, Ctr Cardiol Monzino, Milan, Italy.;Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy..
    Tuomilehto, Jaakko
    Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland.;Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria.;Hosp Univ La Paz IdiPAZ, Inst Invest Sanitaria, Madrid, Spain.;King Abdulaziz Univ, Diabet Res Grp, Jeddah 21413, Saudi Arabia..
    Uitterlinden, Andre G.
    NCHA, NGI, Leiden, Netherlands.;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands..
    Uusitupa, Matti
    Univ Eastern Finland, Dept Publ Hlth & Clin Nutr, Espoo, Finland.;Kuopio Univ Hosp, Res Unit, SF-70210 Kuopio, Finland..
    Verbeek, Andre L. M.
    Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Dept Hlth Evidence, NL-6525 ED Nijmegen, Netherlands..
    Vermeulen, Sita H.
    Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Dept Hlth Evidence, NL-6525 ED Nijmegen, Netherlands.;Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands..
    Viikari, Jorma S.
    Univ Turku, Dept Med, Turku, Finland..
    Vitart, Veronique
    Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland..
    Voelzke, Henry
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Greifswald, Germany..
    Vollenweider, Peter
    Univ Hosp Lausanne CHUV, Dept Internal Med, Lausanne, Switzerland.;Univ Lausanne, Lausanne, Switzerland..
    Waeber, Gerard
    Univ Hosp Lausanne CHUV, Dept Internal Med, Lausanne, Switzerland.;Univ Lausanne, Lausanne, Switzerland..
    Walker, Mark
    Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Newcastle Univ, Inst Cellular Med, Newcastle, NSW, Australia..
    Wallaschofski, Henri
    Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Greifswald, Germany..
    Wareham, Nicholas J.
    Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England..
    Watkins, Hugh
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovac Med, Oxford, England..
    Zeggini, Eleftheria
    Wellcome Trust Sanger Inst, Human Genet, Cambridge, England..
    Chakravarti, Aravinda
    Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Baltimore, MD USA..
    Clegg, Deborah J.
    Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA..
    Cupples, L. Adrienne
    NHLBI, Framingham Heart Study, Framingham, MA USA.;Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA..
    Gordon-Larsen, Penny
    Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC USA.;Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA..
    Jaquish, Cashell E.
    NHLBI, NIH, Bethesda, MD 20892 USA..
    Rao, D. C.
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA.;Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA.;Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA..
    Abecasis, Goncalo R.
    Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    Assimes, Themistocles L.
    Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA..
    Barroso, Ines
    Wellcome Trust Sanger Inst, Human Genet, Cambridge, England.;Addenbrookes Hosp, Inst Metab Sci, NIHR Cambridge Biomed Res Ctr, Cambridge, England.;Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Metab Res Labs, Cambridge CB2 2QQ, England..
    Berndt, Sonja I.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Boehnke, Michael
    Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA..
    Deloukas, Panos
    Wellcome Trust Sanger Inst, Human Genet, Cambridge, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;King Abdulaziz Univ, PACER HD, Jeddah 21413, Saudi Arabia..
    Fox, Caroline S.
    NHLBI, Framingham Heart Study, Framingham, MA USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA..
    Groop, Leif C.
    Lund Univ, Ctr Diabet, Malmo, Sweden.;Lund Univ, Dept Clin Sci, Diabet & Endocrinol Unit, Malmo, Sweden.;Univ Helsinki, FIMM, Helsinki, Finland..
    Hunter, David J.
    MIT, Broad Inst, Cambridge, MA 02139 USA.;Harvard Univ, Cambridge, MA 02138 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA..
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA..
    Kaplan, Robert C.
    Albert Einstein Coll Med, Dept Epidemiol & Popualt Hlth, Bronx, NY 10467 USA..
    McCarthy, Mark I.
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Oxford NIHR Biomed Res Ctr, Oxford, England..
    Mohlke, Karen L.
    Univ N Carolina, Dept Genet, Chapel Hill, NC USA..
    O'Connell, Jeffrey R.
    Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr,Program Personalized, Baltimore, MD 21201 USA..
    Schlessinger, David
    NIA, NIH, Bethesda, MD 20892 USA..
    Strachan, David P.
    St Georges Univ London, Populat Hlth Res Inst, London, England..
    Stefansson, Kari
    Amgen Inc, deCODE Genet, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    van Duijn, Cornelia M.
    Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.;NCHA, NGI, Leiden, Netherlands.;Ctr Med Syst Biol, Leiden, Netherlands..
    Hirschhorn, Joel N.
    MIT, Broad Inst, Cambridge, MA 02139 USA.;Harvard Univ, Cambridge, MA 02138 USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Div Genet, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA..
    Lindgren, Cecilia M.
    MIT, Broad Inst, Cambridge, MA 02139 USA.;Harvard Univ, Cambridge, MA 02138 USA.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England..
    Heid, Iris M.
    Univ Regensburg, Inst Epidemiol & Prevent Med, Dept Genet Epidemiol, D-93053 Regensburg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany..
    North, Kari E.
    Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA.;Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA..
    Borecki, Ingrid B.
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA..
    Kutalik, Zoltan
    Swiss Inst Bioinformat, Lausanne, Switzerland.;Univ Hosp Lausanne CHUV, Inst Social & Prevent Med, Lausanne, Switzerland.;Univ Lausanne, Dept Med Genet, Lausanne, Switzerland..
    Loos, Ruth J. F.
    Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.;Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA..
    The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study2015In: PLOS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 11, no 10, article id e1005378Article in journal (Refereed)
    Abstract [en]

    Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men <= 50y, men > 50y, women <= 50y, women > 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR< 5%) age-specific effects, of which 11 had larger effects in younger (< 50y) than in older adults (>= 50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may providefurther insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.

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  • 475. Witasp, Anna
    et al.
    Carrero, Juan Jesús
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Ahlström, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
    Kullberg, Joel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
    Adamsson, Viola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Helmersson-Karlqvist, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Stenvinkel, Peter
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Inflammatory biomarker pentraxin 3 (PTX3) in relation to obesity, body fat depots, and weight loss2014In: Obesity, ISSN 1930-7381, E-ISSN 1930-739X, Vol. 22, no 5, p. 1373-1379Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: The relation between inflammatory markers, adiposity and disease is under extensive study. Here we tested the hypothesis that the immunomodulatory protein pentraxin 3 (PTX3) is associated with adiposity in the general population.

    DESIGN AND METHODS: Serum PTX3 concentrations, body mass index (BMI), waist circumference (WC) and fat depots, as quantified by dual-energy X-ray absorptiometry and magnetic resonance imaging, were assessed in three community-based cohorts: ULSAM, n = 790, mean age 78 years; PIVUS, n = 1003, mean age 70 years, women 50%; and the NORDIET-trial, n = 86, mean age 53 years, women 63%. Participants were re-examined after 5 years (PIVUS, n = 804) or following a 6-week randomized controlled dietary intervention (NORDIET).

    RESULTS: PTX3 levels were inversely associated with BMI and WC as well as with total and visceral fat (P < 0.05 for all; adjusted for age, inflammatory biomarkers and cardiovascular risk factors). The association between PTX3 and BMI appeared even stronger in nonobese individuals. A decrease in BMI over 5 years as well as weight loss following the NORDIET intervention were associated with increased serum PTX3 concentrations (P < 0.001).

    CONCLUSIONS: These consistent data support an inverse association between circulating PTX3 and anthropometrical measures, calling for further mechanistic studies of the link between PTX3 and fat.

  • 476.
    Wohlin, Martin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Sundstrom, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Andren, Bertil
    Rönn, Monika
    Larsson, Anders
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    An echolucent carotid artery intima-media is a new and independent predictor of mortalityManuscript (Other academic)
  • 477. Wood, Andrew R
    et al.
    Esko, Tonu
    Yang, Jian
    Vedantam, Sailaja
    Pers, Tune H
    Gustafsson, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Chu, Audrey Y
    Estrada, Karol
    Luan, Jian'an
    Kutalik, Zoltán
    Amin, Najaf
    Buchkovich, Martin L
    Croteau-Chonka, Damien C
    Day, Felix R
    Duan, Yanan
    Fall, Tove
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Fehrmann, Rudolf
    Ferreira, Teresa
    Jackson, Anne U
    Karjalainen, Juha
    Lo, Ken Sin
    Locke, Adam E
    Mägi, Reedik
    Mihailov, Evelin
    Porcu, Eleonora
    Randall, Joshua C
    Scherag, André
    Vinkhuyzen, Anna A E
    Westra, Harm-Jan
    Winkler, Thomas W
    Workalemahu, Tsegaselassie
    Zhao, Jing Hua
    Absher, Devin
    Albrecht, Eva
    Anderson, Denise
    Baron, Jeffrey
    Beekman, Marian
    Demirkan, Ayse
    Ehret, Georg B
    Feenstra, Bjarke
    Feitosa, Mary F
    Fischer, Krista
    Fraser, Ross M
    Goel, Anuj
    Gong, Jian
    Justice, Anne E
    Kanoni, Stavroula
    Kleber, Marcus E
    Kristiansson, Kati
    Lim, Unhee
    Lotay, Vaneet
    Lui, Julian C
    Mangino, Massimo
    Leach, Irene Mateo
    Medina-Gomez, Carolina
    Nalls, Michael A
    Nyholt, Dale R
    Palmer, Cameron D
    Pasko, Dorota
    Pechlivanis, Sonali
    Prokopenko, Inga
    Ried, Janina S
    Ripke, Stephan
    Shungin, Dmitry
    Stancáková, Alena
    Strawbridge, Rona J
    Sung, Yun Ju
    Tanaka, Toshiko
    Teumer, Alexander
    Trompet, Stella
    van der Laan, Sander W
    van Setten, Jessica
    Van Vliet-Ostaptchouk, Jana V
    Wang, Zhaoming
    Yengo, Loïc
    Zhang, Weihua
    Afzal, Uzma
    Arnlöv, Johan
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Arscott, Gillian M
    Bandinelli, Stefania
    Barrett, Amy
    Bellis, Claire
    Bennett, Amanda J
    Berne, Christian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Blüher, Matthias
    Bolton, Jennifer L
    Böttcher, Yvonne
    Boyd, Heather A
    Bruinenberg, Marcel
    Buckley, Brendan M
    Buyske, Steven
    Caspersen, Ida H
    Chines, Peter S
    Clarke, Robert
    Claudi-Boehm, Simone
    Cooper, Matthew
    Daw, E Warwick
    De Jong, Pim A
    Deelen, Joris
    Delgado, Graciela
    Denny, Josh C
    Dhonukshe-Rutten, Rosalie
    Dimitriou, Maria
    Doney, Alex S F
    Dörr, Marcus
    Eklund, Niina
    Eury, Elodie
    Folkersen, Lasse
    Garcia, Melissa E
    Geller, Frank
    Giedraitis, Vilmantas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Go, Alan S
    Grallert, Harald
    Grammer, Tanja B
    Gräßler, Jürgen
    Grönberg, Henrik
    de Groot, Lisette C P G M
    Groves, Christopher J
    Haessler, Jeffrey
    Hall, Per
    Haller, Toomas
    Hallmans, Goran
    Hannemann, Anke
    Hartman, Catharina A
    Hassinen, Maija
    Hayward, Caroline
    Heard-Costa, Nancy L
    Helmer, Quinta
    Hemani, Gibran
    Henders, Anjali K
    Hillege, Hans L
    Hlatky, Mark A
    Hoffmann, Wolfgang
    Hoffmann, Per
    Holmen, Oddgeir
    Houwing-Duistermaat, Jeanine J
    Illig, Thomas
    Isaacs, Aaron
    James, Alan L
    Jeff, Janina
    Johansen, Berit
    Johansson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Jolley, Jennifer
    Juliusdottir, Thorhildur
    Junttila, Juhani
    Kho, Abel N
    Kinnunen, Leena
    Klopp, Norman
    Kocher, Thomas
    Kratzer, Wolfgang
    Lichtner, Peter
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Lindström, Jaana
    Lobbens, Stéphane
    Lorentzon, Mattias
    Lu, Yingchang
    Lyssenko, Valeriya
    Magnusson, Patrik K E
    Mahajan, Anubha
    Maillard, Marc
    McArdle, Wendy L
    McKenzie, Colin A
    McLachlan, Stela
    McLaren, Paul J
    Menni, Cristina
    Merger, Sigrun
    Milani, Lili
    Moayyeri, Alireza
    Monda, Keri L
    Morken, Mario A
    Müller, Gabriele
    Müller-Nurasyid, Martina
    Musk, Arthur W
    Narisu, Narisu
    Nauck, Matthias
    Nolte, Ilja M
    Nöthen, Markus M
    Oozageer, Laticia
    Pilz, Stefan
    Rayner, Nigel W
    Renstrom, Frida
    Robertson, Neil R
    Rose, Lynda M
    Roussel, Ronan
    Sanna, Serena
    Scharnagl, Hubert
    Scholtens, Salome
    Schumacher, Fredrick R
    Schunkert, Heribert
    Scott, Robert A
    Sehmi, Joban
    Seufferlein, Thomas
    Shi, Jianxin
    Silventoinen, Karri
    Smit, Johannes H
    Smith, Albert Vernon
    Smolonska, Joanna
    Stanton, Alice V
    Stirrups, Kathleen
    Stott, David J
    Stringham, Heather M
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Swertz, Morris A
    Syvänen, Ann-Christine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Tayo, Bamidele O
    Thorleifsson, Gudmar
    Tyrer, Jonathan P
    van Dijk, Suzanne
    van Schoor, Natasja M
    van der Velde, Nathalie
    van Heemst, Diana
    van Oort, Floor V A
    Vermeulen, Sita H
    Verweij, Niek
    Vonk, Judith M
    Waite, Lindsay L
    Waldenberger, Melanie
    Wennauer, Roman
    Wilkens, Lynne R
    Willenborg, Christina
    Wilsgaard, Tom
    Wojczynski, Mary K
    Wong, Andrew
    Wright, Alan F
    Zhang, Qunyuan
    Arveiler, Dominique
    Bakker, Stephan J L
    Beilby, John
    Bergman, Richard N
    Bergmann, Sven
    Biffar, Reiner
    Blangero, John
    Boomsma, Dorret I
    Bornstein, Stefan R
    Bovet, Pascal
    Brambilla, Paolo
    Brown, Morris J
    Campbell, Harry
    Caulfield, Mark J
    Chakravarti, Aravinda
    Collins, Rory
    Collins, Francis S
    Crawford, Dana C
    Cupples, L Adrienne
    Danesh, John
    de Faire, Ulf
    den Ruijter, Hester M
    Erbel, Raimund
    Erdmann, Jeanette
    Eriksson, Johan G
    Farrall, Martin
    Ferrannini, Ele
    Ferrières, Jean
    Ford, Ian
    Forouhi, Nita G
    Forrester, Terrence
    Gansevoort, Ron T
    Gejman, Pablo V
    Gieger, Christian
    Golay, Alain
    Gottesman, Omri
    Gudnason, Vilmundur
    Gyllensten, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Haas, David W
    Hall, Alistair S
    Harris, Tamara B
    Hattersley, Andrew T
    Heath, Andrew C
    Hengstenberg, Christian
    Hicks, Andrew A
    Hindorff, Lucia A
    Hingorani, Aroon D
    Hofman, Albert
    Hovingh, G Kees
    Humphries, Steve E
    Hunt, Steven C
    Hypponen, Elina
    Jacobs, Kevin B
    Jarvelin, Marjo-Riitta
    Jousilahti, Pekka
    Jula, Antti M
    Kaprio, Jaakko
    Kastelein, John J P
    Kayser, Manfred
    Kee, Frank
    Keinanen-Kiukaanniemi, Sirkka M
    Kiemeney, Lambertus A
    Kooner, Jaspal S
    Kooperberg, Charles
    Koskinen, Seppo
    Kovacs, Peter
    Kraja, Aldi T
    Kumari, Meena
    Kuusisto, Johanna
    Lakka, Timo A
    Langenberg, Claudia
    Le Marchand, Loic
    Lehtimäki, Terho
    Lupoli, Sara
    Madden, Pamela A F
    Männistö, Satu
    Manunta, Paolo
    Marette, André
    Matise, Tara C
    McKnight, Barbara
    Meitinger, Thomas
    Moll, Frans L
    Montgomery, Grant W
    Morris, Andrew D
    Morris, Andrew P
    Murray, Jeffrey C
    Nelis, Mari
    Ohlsson, Claes
    Oldehinkel, Albertine J
    Ong, Ken K
    Ouwehand, Willem H
    Pasterkamp, Gerard
    Peters, Annette
    Pramstaller, Peter P
    Price, Jackie F
    Qi, Lu
    Raitakari, Olli T
    Rankinen, Tuomo
    Rao, D C
    Rice, Treva K
    Ritchie, Marylyn
    Rudan, Igor
    Salomaa, Veikko
    Samani, Nilesh J
    Saramies, Jouko
    Sarzynski, Mark A
    Schwarz, Peter E H
    Sebert, Sylvain
    Sever, Peter
    Shuldiner, Alan R
    Sinisalo, Juha
    Steinthorsdottir, Valgerdur
    Stolk, Ronald P
    Tardif, Jean-Claude
    Tönjes, Anke
    Tremblay, Angelo
    Tremoli, Elena
    Virtamo, Jarmo
    Vohl, Marie-Claude
    Amouyel, Philippe
    Asselbergs, Folkert W
    Assimes, Themistocles L
    Bochud, Murielle
    Boehm, Bernhard O
    Boerwinkle, Eric
    Bottinger, Erwin P
    Bouchard, Claude
    Cauchi, Stéphane
    Chambers, John C
    Chanock, Stephen J
    Cooper, Richard S
    de Bakker, Paul I W
    Dedoussis, George
    Ferrucci, Luigi
    Franks, Paul W
    Froguel, Philippe
    Groop, Leif C
    Haiman, Christopher A
    Hamsten, Anders
    Hayes, M Geoffrey
    Hui, Jennie
    Hunter, David J
    Hveem, Kristian
    Jukema, J Wouter
    Kaplan, Robert C
    Kivimaki, Mika
    Kuh, Diana
    Laakso, Markku
    Liu, Yongmei
    Martin, Nicholas G
    März, Winfried
    Melbye, Mads
    Moebus, Susanne
    Munroe, Patricia B
    Njølstad, Inger
    Oostra, Ben A
    Palmer, Colin N A
    Pedersen, Nancy L
    Perola, Markus
    Pérusse, Louis
    Peters, Ulrike
    Powell, Joseph E
    Power, Chris
    Quertermous, Thomas
    Rauramaa, Rainer
    Reinmaa, Eva
    Ridker, Paul M
    Rivadeneira, Fernando
    Rotter, Jerome I
    Saaristo, Timo E
    Saleheen, Danish
    Schlessinger, David
    Slagboom, P Eline
    Snieder, Harold
    Spector, Tim D
    Strauch, Konstantin
    Stumvoll, Michael
    Tuomilehto, Jaakko
    Uusitupa, Matti
    van der Harst, Pim
    Völzke, Henry
    Walker, Mark
    Wareham, Nicholas J
    Watkins, Hugh
    Wichmann, H-Erich
    Wilson, James F
    Zanen, Pieter
    Deloukas, Panos
    Heid, Iris M
    Lindgren, Cecilia M
    Mohlke, Karen L
    Speliotes, Elizabeth K
    Thorsteinsdottir, Unnur
    Barroso, Inês
    Fox, Caroline S
    North, Kari E
    Strachan, David P
    Beckmann, Jacques S
    Berndt, Sonja I
    Boehnke, Michael
    Borecki, Ingrid B
    McCarthy, Mark I
    Metspalu, Andres
    Stefansson, Kari
    Uitterlinden, André G
    van Duijn, Cornelia M
    Franke, Lude
    Willer, Cristen J
    Price, Alkes L
    Lettre, Guillaume
    Loos, Ruth J F
    Weedon, Michael N
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    O'Connell, Jeffrey R
    Abecasis, Goncalo R
    Chasman, Daniel I
    Goddard, Michael E
    Visscher, Peter M
    Hirschhorn, Joel N
    Frayling, Timothy M
    Defining the role of common variation in the genomic and biological architecture of adult human height2014In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 46, no 11, p. 1173-1186Article in journal (Refereed)
    Abstract [en]

    Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

  • 478. Wormser, David
    et al.
    Di Angelantonio, Emanuele
    Kaptoge, Stephen
    Wood, Angela M.
    Gao, Pei
    Sun, Qi
    Walldius, Goeran
    Selmer, Randi
    Verschuren, W. M. Monique
    Bueno-de-Mesquita, H. Bas
    Engstrom, Gunnar
    Ridker, Paul M.
    Njolstad, Inger
    Iso, Hiroyasu
    Holme, Ingar
    Giampaoli, Simona
    Tunstall-Pedoe, Hugh
    Gaziano, J. Michael
    Brunner, Eric
    Kee, Frank
    Tosetto, Alberto
    Meisinger, Christa
    Brenner, Hermann
    Ducimetiere, Pierre
    Whincup, Peter H.
    Tipping, Robert W.
    Ford, Ian
    Cremer, Peter
    Hofman, Albert
    Wilhelmsen, Lars
    Clarke, Robert
    de Boer, Ian H.
    Jukema, J. Wouter
    Ibanez, Alejandro Marin
    Lawlor, Debbie A.
    D'Agostino, Ralph B., Sr.
    Rodriguez, Beatriz
    Casiglia, Edoardo
    Stehouwer, Coen D. A.
    Simons, Leon A.
    Nietert, Paul J.
    Barrett-Connor, Elizabeth
    Panagiotakos, Demosthenes B.
    Bjorkelund, Cecilia
    Strandberg, Timo E.
    Wassertheil-Smoller, Sylvia
    Blazer, Dan G.
    Meade, Tom W.
    Welin, Lennart
    Svärdsudd, Kurt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Woodward, Mark
    Nissinen, Aulikki
    Kromhout, Daan
    Jorgensen, Torben
    Tilvis, Reijo S.
    Guralnik, Jack M.
    Rosengren, Annika
    Taylor, James O.
    Kiechl, Stefan
    Dagenais, Gilles R.
    Fowkes, F. Gerry R.
    Wallace, Robert B.
    Khaw, Kay-Tee
    Shaffer, Jonathan A.
    Visser, Marjolein
    Kauhanen, Jussi
    Salonen, Jukka T.
    Gallacher, John
    Ben-Shlomo, Yoav
    Kitamura, Akihiko
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Wennberg, Patrik
    Kiyohara, Yutaka
    Daimon, Makoto
    Gomez de la Camara, Agustin
    Cooper, Jackie A.
    Onat, Altan
    Devereux, Richard
    Mukamal, Kenneth J.
    Dankner, Rachel
    Knuiman, Matthew W.
    Crespo, Carlos J.
    Gansevoort, Ron T.
    Goldbourt, Uri
    Nordestgaard, Borge G.
    Shaw, Jonathan E.
    Mussolino, Michael
    Nakagawa, Hidaeki
    Fletcher, Astrid
    Kuller, Lewis H.
    Gillum, Richard F.
    Gudnason, Vilmundur
    Assmann, Gerd
    Wald, Nicholas
    Jousilahti, Pekka R.
    Greenland, Philip
    Trevisan, Maurizio
    Ulmer, Hanno
    Butterworth, Adam S.
    Folsom, Aaron R.
    Davey-Smith, George
    Hu, Frank B.
    Danesh, John
    Tipping,
    Ford, CE
    Simpson,
    Walldius, G
    Jungner, I
    Folsom, AR
    Demerath,
    Franceschini, N
    Lutsey,
    Panagiotakos, DB
    Pitsavos, C
    Chrysohoou, C
    Stefanadis,
    Shaw, JE
    Atkins, R
    Zimmet, PZ
    Barr, EL
    Knuiman, MW
    Whincup,
    Wannamethee,
    Morris,
    Willeit, J
    Kiechl,
    Weger,
    Oberhollenzer, F
    Wald, N
    Ebrahim, S
    Lawlor, DA
    Gallacher, J
    Ben-Shlomo,
    Yarnell,
    Casiglia,
    Tikhonoff,
    Greenland, P
    Shay,
    Garside,
    Nietert,
    Sutherland, SE
    Bachman, DL
    Keil,
    de Boer, IH
    Kizer, JR
    Psaty, BM
    Mukamal, KJ
    Nordestgaard, BG
    Tybjærg-Hansen A, A
    Jensen, GB
    Schnohr, P
    Giampaoli, S
    Palmieri,
    Panico,
    Pilotto, L
    Vanuzzo, D
    de la Cámara, AG
    Simons, LA
    Simons, J
    McCallum, J
    Friedlander,
    Gerry, F
    Fowkes, R
    Price, JF
    Lee, AJ
    Taylor, Taylor JO
    Guralnik, JM
    Phillips, CL
    Kohout, FJ
    Kohout, FJ
    Cornoni-Huntley, JC
    Guralnik, JM
    Blazer, DG
    Guralnik,
    Phillips, CL
    Phillips, CL
    Guralnik, JM
    Khaw, KT
    Wareham, NJ
    Wareham, NJ
    Brenner, H
    Schöttker, B
    Müller, H
    Rothenbacher, D
    Wennberg, P
    Jansson, JH
    Nissinen, A
    Donfrancesco, C
    Giampaoli, S
    Woodward, M
    Vartiainen, E
    Jousilahti, PR
    Harald, K
    Salomaa, V
    D'Agostino, RB
    Vasan, RS
    Fox, CS
    Pencina, MJ
    Daimon, M
    Oizumi, T
    Kayama, T
    Kato, T
    Bladbjerg, EM
    Danesh, J
    Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis2012In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 41, no 5, p. 1419-1433Article in journal (Refereed)
    Abstract [en]

    Background

    The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.

    Methods

    We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.

    Results

    For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.

    Conclusion

    Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

  • 479.
    Wu, Jason H. Y.
    et al.
    Univ New South Wales, George Inst Global Hlth, Fac Med, Sydney, NSW 2050, Australia..
    Marklund, Matti
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Imamura, Fumiaki
    Univ Cambridge, MRC, Epidemiol Unit, Cambridge, England..
    Tintle, Nathan
    Dordt Coll, Dept Math & Stat, Sioux Ctr, IA USA..
    Korat, Andres V. Ardisson
    Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA..
    de Goede, Janette
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands..
    Zhou, Xia
    Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA..
    Yang, Wei-Sin
    Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan..
    Otto, Marcia C. de Oliveira
    Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA..
    Kroger, Janine
    German Inst Human Nutr, Potsdam, Germany..
    Qureshi, Waqas
    Wake Forest Univ, Winston Salem, NC 27109 USA..
    Virtanen, Jyrki K.
    Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland..
    Bassett, Julie K.
    Canc Council Victoria, Melbourne, Vic, Australia..
    Frazier-Wood, Alexis C.
    ARS, USDA, Childrens Nutr Res Ctr, Houston, TX USA..
    Lankinen, Maria
    Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland..
    Murphy, Rachel A.
    Univ British Columbia, Vancouver, BC, Canada..
    Rajaobelina, Kalina
    Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, UMR 1219, Bordeaux, France..
    Del Gobbo, Liana C.
    Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA..
    Forouhi, Nita G.
    Univ Cambridge, MRC, Epidemiol Unit, Cambridge, England..
    Luben, Robert
    Univ Cambridge, Dept Publ Hlth & Primary Care, Sch Clin Med, Cambridge, England..
    Khaw, Kay-Tee
    Univ Cambridge, Dept Publ Hlth & Primary Care, Sch Clin Med, Cambridge, England.;Dordt Coll, Dept Math & Stat, Sioux Ctr, IA USA..
    Wareham, Nick
    Univ Cambridge, MRC, Epidemiol Unit, Cambridge, England..
    Kalsbeek, Anya
    Dordt Coll, Dept Math & Stat, Sioux Ctr, IA USA.;Dordt Coll, Dept Biol, Sioux Ctr, IA USA..
    Veenstra, Jenna
    Dordt Coll, Dept Math & Stat, Sioux Ctr, IA USA.;Dordt Coll, Dept Biol, Sioux Ctr, IA USA..
    Luo, Juhua
    Indiana Univ, Dept Epidemiol & Biostat, Bloomington, IN USA..
    Hu, Frank B.
    Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA..
    Lin, Hung-Ju
    Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan..
    Siscovick, David S.
    New York Acad Med, New York, NY USA..
    Boeing, Heiner
    German Inst Human Nutr, Potsdam, Germany..
    Chen, Tzu-An
    ARS, USDA, Childrens Nutr Res Ctr, Houston, TX USA..
    Steffen, Brian
    Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA..
    Steffen, Lyn M.
    Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA..
    Hodge, Allison
    Canc Council Victoria, Melbourne, Vic, Australia..
    Eriksdottir, Gudny
    Iceland Heart Inst, Kopavogur, Iceland..
    Smith, Albert V.
    Iceland Heart Inst, Kopavogur, Iceland..
    Gudnason, Vilmunder
    Iceland Heart Inst, Kopavogur, Iceland..
    Harris, Tamara B.
    NIA, Bethesda, MD 20892 USA..
    Brouwer, Ingeborg A.
    Vrije Univ Amsterdam, Hlth Sci, Amsterdam, Netherlands..
    Berr, Claudine
    Montpellier Univ, INSERM, U1061, Neuropsychiat Epidemiol & Clin Res, Montpellier, France.;Montpellier Univ, Montpellier Univ Hosp, Montpellier, France..
    Helmer, Catherine
    Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, UMR 1219, Bordeaux, France..
    Samieri, Cecilia
    Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, UMR 1219, Bordeaux, France..
    Laakso, Markku
    Univ Eastern Finland, Inst Clin Med, Kuopio, Finland..
    Tsai, Michael Y.
    Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA..
    Giles, Graham G.
    Canc Council Victoria, Melbourne, Vic, Australia..
    Nurmi, Tarja
    Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland..
    Wagenknecht, Lynne
    Wake Forest Univ, Winston Salem, NC 27109 USA..
    Schulze, Matthias B.
    German Inst Human Nutr, Potsdam, Germany..
    Lemaitre, Rozenn N.
    Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98195 USA..
    Chien, Kuo-Liong
    Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.;Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan..
    Soedamah-Muthu, Sabita S.
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands..
    Geleijnse, Johanna M.
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands..
    Sun, Qi
    Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA..
    Harris, William S.
    Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA.;OmegaQuant Analyt, Sioux Falls, SD USA..
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Arnlov, Johan
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med, Stockholm, Sweden.;Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden..
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Micha, Renata
    Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA..
    Mozaffarian, Dariush
    Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA..
    Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies2017In: The Lancet Diabetes and Endocrinology, ISSN 2213-8587, E-ISSN 2213-8595, Vol. 5, no 12, p. 965-974Article in journal (Refereed)
    Abstract [en]

    Background The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes. Methods We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes. We analysed data from 20 prospective cohort studies from ten countries (Iceland, the Netherlands, the USA, Taiwan, the UK, Germany, Finland, Australia, Sweden, and France), with biomarkers sampled between 1970 and 2010. Participants included in the analyses were aged 18 years or older and had data available for linoleic acid and arachidonic acid biomarkers at baseline. We excluded participants with type 2 diabetes at baseline. The main outcome was the association between omega-6 PUFA biomarkers and incident type 2 diabetes. We assessed the relative risk of type 2 diabetes prospectively for each cohort and lipid compartment separately using a prespecified analytic plan for exposures, covariates, effect modifiers, and analysis, and the findings were then pooled using inverse-variance weighted meta-analysis. Findings Participants were 39 740 adults, aged (range of cohort means) 49-76 years with a BMI (range of cohort means) of 23.3-28.4 kg/m(2), who did not have type 2 diabetes at baseline. During a follow-up of 366 073 person-years, we identified 4347 cases of incident type 2 diabetes. In multivariable-adjusted pooled analyses, higher proportions of linoleic acid biomarkers as percentages of total fatty acid were associated with a lower risk of type 2 diabetes overall (risk ratio [RR] per interquintile range 0.65, 95% CI 0.60-0.72, p<0.0001; I-2=53.9%, p(heterogeneity) = 0.002). The associations between linoleic acid biomarkers and type 2 diabetes were generally similar in different lipid compartments, including phospholipids, plasma, cholesterol esters, and adipose tissue. Levels of arachidonic acid biomarker were not significantly associated with type 2 diabetes risk overall (RR per interquintile range 0.96, 95% CI 0.88-1.05; p=0.38; I-2 = 63.0%, p(heterogeneity) < 0.0001). The associations between linoleic acid and arachidonic acid biomarkers and the risk of type 2 diabetes were not significantly modified by any prespecified potential sources of heterogeneity (ie, age, BMI, sex, race, aspirin use, omega-3 PUFA levels, or variants of the FADS gene; all p(heterogeneity) >= 0-13). Interpretation Findings suggest that linoleic acid has long-term benefits for the prevention of type 2 diabetes and that arachidonic acid is not harmful.

  • 480. Wuopio, Jonas
    et al.
    Östgren, Carl Johan
    Länne, Toste
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Ruge, Toralph
    Carlsson, Axel C
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Nyström, Fredrik H
    Ärnlöv, Johan
    The association between circulating endostatin and a disturbed circadian blood pressure pattern in patients with type 2 diabetes.2018In: Blood Pressure, ISSN 0803-7051, E-ISSN 1651-1999, Vol. 27, no 4, p. 215-221Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Endostatin, cleaved from collagen XVIII in the extracellular matrix, is a promising circulating biomarker for cardiovascular damage. It possesses anti-angiogenic and anti-fibrotic functions and has even been suggested to be involved in blood pressure regulation. Less is known if endostatin levels relate to circadian blood pressure patterns. In the present paper we studied the association between circulating levels of endostatin and nocturnal dipping in blood pressure.

    METHODS: We used the CARDIPP-study, a cohort of middle aged, type 2 diabetics (n = 593, 32% women), with data on both 24-hour and office blood pressure, serum-endostatin, cardiovascular risk factors, and incident major cardiovascular events. Nocturnal dipping was defined as a >10% difference between day- and night-time blood pressures.

    RESULTS: Two-hundred four participants (34%) were classified as non-dippers. The mean endostatin levels were significantly higher in non-dippers compared to dippers (mean ± standard deviation: 62.6 ± 1.8 µg/l vs. 58.7 ± 1.6 µg/l, respectively, p = .007). Higher serum levels of endostatin were associated with a diminished decline in nocturnal blood pressure adjusted for age, sex, HbA1c, mean systolic day blood pressure, hypertension treatment, glomerular filtration rate, and prevalent cardiovascular disease (regression coefficient per SD increase of endostatin -0.01, 95% CI, -0.02-(-0.001), p = .03). Structural equation modelling analyses suggest that endostatin mediates 7% of the association between non-dipping and major cardiovascular events.

    CONCLUSION: We found an independent association between higher circulating levels of endostatin and a reduced difference between day- and night-time systolic blood pressure in patients with type 2 diabetes. Yet endostatin mediated only a small portion of the association between non-dipping and cardiovascular events arguing against a clinical utility of our findings.

  • 481.
    Wändell, Per
    et al.
    Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
    Carlsson, Axel C
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
    Gasevic, Danijela
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Coll Med & Vet Med, Edinburgh, Midlothian, Scotland;Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
    Holzmann, Martin J.
    Karolinska Univ Hosp, Funct Area Emergency Med, Stockholm, Sweden;Karolinska Inst, Dept Internal Med, Stockholm, Sweden.
    Ärnlöv, Johan
    Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden;Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden.
    Sundquist, Jan
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden;Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA;Shimane Univ, Sch Med, Ctr Community Based Healthcare Res & Educ CoHRE, Dept Funct Pathol, Matsue, Shimane, Japan.
    Sundquist, Kristina
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden;Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA;Shimane Univ, Sch Med, Ctr Community Based Healthcare Res & Educ CoHRE, Dept Funct Pathol, Matsue, Shimane, Japan.
    Socioeconomic factors and mortality in patients with atrial fibrillation: a cohort study in Swedish primary care2018In: European Journal of Public Health, ISSN 1101-1262, E-ISSN 1464-360X, Vol. 28, no 6, p. 1103-1109Article in journal (Refereed)
    Abstract [en]

    Background: Preventing ischaemic stroke attracts significant focus in atrial fibrillation (OAF) cases. Less is known on the association between socioeconomic factors and mortality and cardiovascular outcomes in patients with AF. Methods: Our study population included adults (On=12 283) >= 45 years diagnosed with AF at 75 primary care centres in Sweden 2001-07. Cox regression was used to calculate hazard ratios (OHRs) with 95% confidence intervals (OCIs) for the association between the exposures educational level, marital status, neighbourhood socioeconomic status and the outcomes all-cause mortality, after adjustment for age, and comorbid cardiovascular conditions. Results: During a mean of 5.8 years (OSD 2.4) of follow-up, 3954 (O32.3%) patients had died; 1971 were women (O35.0%) and 1983 were men (O29.8%). Higher educational level was associated with a reduced mortality in fully adjusted models: HR 0.85 (O95% CI 0.77-0.96) for secondary school in men, HR 0.73 (O95% CI 0.60-0.88) for college/university in women, and HR 0.82 (O95% CI 0.71-0.94) for college/university in men, compared to primary school. Unmarried men and divorced men had an increased risk of death, compared with married men: HR 1.25 (O95% CI 1.05-1.50), and HR 1.23 (O95% CI 1.07-1.42), respectively. College/university education level was also associated with lower risk of myocardial infarction in men and women, and lower risk of congestive heart failure in women. Conclusion: More attention could be paid to individuals of lower levels of formal education, and unmarried men, in order to provide timely management for AF and prevent its debilitating complications.

  • 482.
    Wändell, Per
    et al.
    Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.;Stockholm Cty Council, Acad Primary Healthcare Ctr, Huddinge, Sweden..
    Carlsson, Axel C.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
    Holzmann, Martin J.
    Karolinska Univ Hosp, Dept Emergency Med, Stockholm, Sweden.;Karolinska Inst, Dept Internal Med, Stockholm, Sweden..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden..
    Johansson, Sven-Erik
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Sundquist, Jan
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Sundquist, Kristina
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden..
    Warfarin treatment and risk of stroke among primary care patients with atrial fibrillation2016In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 50, no 5-6, p. 311-316Article in journal (Refereed)
    Abstract [en]

    Objective. Our aim was to study the risk of a first ischaemic stroke (IS) in patients with atrial fibrillation (AF) treated in primary healthcare.

    Design. The study population included all adults (n=11,517), 45 years and older diagnosed with AF, from 75 primary care centres in Sweden between 2001 and 2007. IS was defined as a hospital care event of stroke between 2001 and 2010. Association between incident stroke and warfarin treatment was explored using Cox regression analysis, with hazard ratios (HRs), and 95% confidence intervals (95%CIs). Adjustment was made for age, socioeconomic factors and co-morbidity.

    Results. Persistent treatment with warfarin was present among 33.7% of women and 40.0% among men. Persistent warfarin treatment, compared to no persistent treatment, was associated with a stroke preventing effect with fully adjusted HRs of 0.25 (95%CI 0.18-0.36) in women, and 0.25 (95%CI 0.19-0.32) in men. A CHA(2)DS(2)-VASc score of at least two among women, and three among men, was associated with a stroke risk exceeding 18% during a mean follow-up of 5.4 years. Risk of haemorrhagic stroke was not increased.

    Conclusions. Warfarin is effective in preventing stroke in AF patients in primary healthcare.

  • 483.
    Wändell, Per
    et al.
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden.
    Carlsson, Axel C
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden;Uppsala Univ, Dept Med Sci, Cardiovasc Epidemiol, Uppsala, Sweden.
    Holzmann, Martin J.
    Karolinska Inst, Dept Internal Med, Stockholm, Sweden;Karolinska Univ Hosp, Funct Area Emergency Med, Stockholm, Sweden.
    Ärnlöv, Johan
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden;Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden.
    Sundquist, Jan
    Shimane Univ, Sch Med, Dept Funct Pathol, Ctr Community Based Healthcare Res & Educ CoHRE, Matsue, Shimane, Japan;Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden;Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Family Med & Community Hlth, New York, NY 10029 USA.
    Sundquist, Kristina
    Shimane Univ, Sch Med, Dept Funct Pathol, Ctr Community Based Healthcare Res & Educ CoHRE, Matsue, Shimane, Japan;Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden;Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Family Med & Community Hlth, New York, NY 10029 USA.
    Associations between relevant cardiovascular pharmacotherapies and incident heart failure in patients with atrial fibrillation: a cohort study in primary care2018In: Journal of Hypertension, ISSN 0263-6352, E-ISSN 1473-5598, Vol. 36, no 9, p. 1929-1935Article in journal (Refereed)
    Abstract [en]

    Objective: To study association between relevant cardiovascular pharmacotherapy and incident congestive heart failure (CHF) in patients with atrial fibrillation treated in primary health care.

    Methods: Study population included all adults (n=7975) aged 45 years and older diagnosed with atrial fibrillation at 75 primary care centers in Sweden between 2001 and 2007. Outcome was defined as a first diagnosis of CHF post-atrial fibrillation diagnosis. Association between CHF and treatment with relevant cardiovascular pharmacotherapies (beta blockers, calcium blockers, digitalis, diuretics, RAS blockers, and statins) was explored using Cox regression analysis with hazard ratios and 95% CIs. Adjustments were made for age, sociodemographic variables, and comorbid conditions (with or without cardiovascular disorders).

    Results: During a mean of 5.7 years (SD 2.3) of follow-up, totally 1552 patients (19.5%; 803 women and 749 men) had a recorded CHF diagnosis. Thiazides (hazard ratio 0.74, 95% CI 0.65-0.84), vessel-active calcium channel blockers (hazard ratio 0.76, 95% CI 0.67-0.86), and nonselective beta blockers (hazard ratio 0.84, 95% CI 0.72-0.98), with specifically sotalol representing 80% of nonselective beta blockers (hazard ratio 0.81, 95% CI 0.69-0.97), were associated with lower CHF risk in fully adjusted models. Loop diuretics (hazard ratio 1.41, 95% CI 1.25-1.57) were associated with a higher risk. Findings for thiazides and vessel-active channel blockers were consistent in the tested subgroups.

    Conclusion: In this clinical setting, we found that thiazides, vessel-active calcium channel blockers, and nonselective beta blockers (specifically sotalol) were associated with a lower risk of incident CHF among patients with atrial fibrillation. The findings of the present study need to be confirmed in other settings.

  • 484.
    Wändell, Per
    et al.
    Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden..
    Carlsson, Axel C
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
    Holzmann, Martin J.
    Karolinska Univ Hosp, Funct Area Emergency Med, Stockholm, Sweden.;Solna Karolinska Inst, Dept Internal Med, Stockholm, Sweden..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.;Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden..
    Sundquist, Jan
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden.;Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA..
    Sundquist, Kristina
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden.;Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA..
    Comparison of Mortality and Nonfatal Cardiovascular Events in Adults With Atrial Fibrillation With Versus Without Levothyroxine Treatment2017In: American Journal of Cardiology, ISSN 0002-9149, E-ISSN 1879-1913, Vol. 120, no 11, p. 1974-1979Article in journal (Refereed)
    Abstract [en]

    Levothyroxine has been suggested to be cardiotoxic, but previous studies on the risk of cardiovascular events associated with levothyroxine treatment have been inconclusive. We aimed to study the association between levothyroxine treatment and all-cause mortality as well as cardiovascular events. Study population included all adults (n = 12,283) >= 45 years diagnosed with atrial fibrillation (AF) at 75 primary care centers in Sweden in 2001 to 2007, with (n = 1,189; 283 men and 906 women) or without (n = 11,094) levothyroxine treatment. Outcome was defined as all-cause mortality and cardiovascular events, that is, myocardial infarction, ischemic stroke, and congestive heart failure until December 31, 2010. During a mean 5.8 years (standard deviation 2.4 years) of follow-up, a total of 3,954 patients died (32.2%), among whom 92 men (32.5%) and 266 women (29.4%) were treated with levothyroxine. In fully adjusted Cox regression models (age, co-morbidity, socioeconomic factors, and warfarin treatment), a significant association between levothyroxine treatment and lower mortality was found among women (hazard ratio 0.78, 95% confidence interval 0.68 to 0.91), but not among men (hazard ratio 0.87, 95% confidence interval 0.69 to 1.10). In the secondary analysis, levothyroxine treatment was not associated with the risk of myocardial infarction, ischemic stroke, or congestive heart failure (p > 0.05). In conclusion, in a large representative cohort, we found that levothyroxine treatment decreased the mortality risk in women with AF, which suggests that such treatment could be of benefit in this setting.

  • 485.
    Wändell, Per
    et al.
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden..
    Carlsson, Axel C
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden.
    Holzmann, Martin J.
    Karolinska Univ Hosp, Funct Area Emergency Med, Stockholm, Sweden.;Karolinska Inst, Dept Internal Med Solna, Stockholm, Sweden..
    Ärnlöv, Johan
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden.;Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden..
    Sundquist, Jan
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden.;Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Family Med & Community Hlth, New York, NY 10029 USA..
    Sundquist, Kristina
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden.;Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Family Med & Community Hlth, New York, NY 10029 USA..
    Mortality in patients with atrial fibrillation and common co-morbidities - a cohort study in primary care2018In: Annals of Medicine, ISSN 0785-3890, E-ISSN 1365-2060, Vol. 50, no 2, p. 156-163Article in journal (Refereed)
    Abstract [en]

    Objective: To study the association between cardiovascular co-morbidities and mortality risk in primary care patients with atrial fibrillation.

    Methods: The study population included all adults (n=12,283) >= 45 years diagnosed with AF at 75 primary care centres in Sweden between 2001 and 2007. The outcome was mortality (until 2010) and data were explored for co-morbidities using Cox regression with hazard ratios (HRs). Analyses were performed stratified by sex and by age-group (45-64, 65-74 and >= 75 years of age) with adjustment for age, socio-economic factors and relevant co-morbidities.

    Results: During a mean of 5.8 years (standard deviation 2.4) of follow-up, 3954 (32%) patients died (1971 (35%) women, and 1983 (30%) men). High HRs were found for congestive heart disease (CHF) and cerebrovascular diseases for all age-groups among men and women (except for the 45-64 year old women); for coronary heart disease among the oldest men; for diabetes among the 65-74 year old men and the 45-64 year old women. Low HRs were found for hypertension among women >= 75 years of age.

    Conclusions: In this clinical setting, CHF and cerebrovascular diseases were consistently associated with mortality in all age-groups. The possible protective effect by hypertension among elderly women should be interpreted with caution.

  • 486.
    Wändell, Per
    et al.
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Alfred Nobels Alle 23, S-14183 Huddinge, Sweden.
    Carlsson, Axel C
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Alfred Nobels Alle 23, S-14183 Huddinge, Sweden.
    Sundquist, Jan
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden;Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA;Shimane Univ, Sch Med, Dept Funct Pathol, Ctr Community Based Healthcare Res & Educ CoHRE, Matsue, Shimane, Japan.
    Sundquist, Kristina
    Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden;Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA;Shimane Univ, Sch Med, Dept Funct Pathol, Ctr Community Based Healthcare Res & Educ CoHRE, Matsue, Shimane, Japan.
    Antihypertensive drugs and relevant cardiovascular pharmacotherapies and the risk of incident dementia in patients with atrial fibrillation2018In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 272, p. 149-154Article in journal (Refereed)
    Abstract [en]

    Background: Atrial fibrillation (AF) and dementia arc predominant among the elderly; patients with AF have an increased dementia risk. We aimed to study if prescribed antihypertensive drugs and cardiovascular pharmacotherapies are associated with a lower relative risk of dementia.

    Methods: All included patients were >= 45 years and diagnosed with AF in primary care; 12,096 (6580 men and 5516 women) in Sweden. We excluded patients with a dementia diagnosis before onset of AF. Cox regression was used (hazard ratios, HRs, and 95% confidence interval, CI) with adjustments for sex, age, socioeconomic factors and co-morbidities.

    Results: Incident dementia occurred in 750 patients (6.2%) during an average of 5.6 years of follow-up (a total of 69,214 person-years). Patients prescribed thiazides HR 0.81 (95% CI 0.66-0.99) and warfarin HR 0.78 (95% CI 0.66-0.92) had a lower risk of dementia than patients without these drugs. The use of 1-4 of the different antihypertensive drug classes ( thiazides, beta blocker, vessel active calcium channel blockers or renin angiotensin aldosterone (RAAS) blockers) were associated with a reduction of incident dementia; HR 0.80 (95% CI 0.64-1.00) for one to two drugs, and HR 0.63 (95% CI 0.46-0.84) for three or four drugs, versus having no prescribed anlihy-pertensive drugs. The combination of a RAAS-blocker and a thiazide was significant, HR 0.70 (95% CI 0.53-0.92), versus not having that particular combination prescribed, while RAAS-blockers or thiazides separately were not significant.

    Conclusion: Prescribed antihypertensive drugs, including thiazide/RAAS-blocker combination therapy and use of warfarin, were associated with a decreased incidence of dementia.

  • 487.
    Wångdahl, Josefin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Lytsy, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Mårtensson, Lena
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden..
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Health literacy and refugees’ experiences of the health examination for asylum seekers: a Swedish cross-sectional study2017Conference paper (Refereed)
  • 488.
    Wångdahl, Josefin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Lytsy, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Mårtensson, Lena
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden..
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Health literacy and refugees’ experiences of the health examination for asylum seekers: a Swedish cross-sectional study2017Conference paper (Refereed)
  • 489.
    Wångdahl, Josefin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Lytsy, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Mårtensson, Lena
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden..
    Experiences of the Health Examination for Asylum Seeker: Focus Group Discussions with Arabic and Somali Speaking Refugees in Sweden2017Conference paper (Refereed)
  • 490.
    Wångdahl, Josefin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Lytsy, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Mårtensson, Lena
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden..
    Experiences of the Health Examination for Asylum Seeker: Focus Group Discussions with Arabic and Somali Speaking Refugees in Sweden2017Conference paper (Refereed)
  • 491.
    Wångdahl, Josefin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Lytsy, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Mårtensson, Lena
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden..
    Experiences of the Health Examination for Asylum Seeker: Focus Group Discussions with Arabic and Somali Speaking Refugees in Sweden2017Conference paper (Refereed)
  • 492.
    Wångdahl, Josefin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Lytsy, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Mårtensson, Lena
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden..
    Experiences of the HealthExamination for Asylum Seeker: Focus Group Discussions with Arabic and Somali Speaking Refugees in Sweden2017Conference paper (Refereed)
  • 493.
    Wångdahl, Josefin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Westerling, Ragnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Lytsy, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social Medicine.
    Mårtensson, Lena
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden..
    Experiences of the Health Examination for Asylum Seekers: Focus Group Discussions with Arabic and Somali Speaking Refugees in SwedenIn: Article in journal (Refereed)
  • 494. Xiong, Zibo
    et al.
    Xu, Hong
    Huang, Xiaoyan
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Qureshi, Abdul Rashid
    Cederholm, Tommy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Sjögren, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Lindholm, Bengt
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Carrero, Juan Jesus
    Nonesterified Fatty Acids and Cardiovascular Mortality in Elderly Men with CKD2015In: American Society of Nephrology. Clinical Journal, ISSN 1555-9041, E-ISSN 1555-905X, Vol. 10, no 4, p. 584-591Article in journal (Refereed)
    Abstract [en]

    Background and objectives Although nonesterified fatty acids (NEFAs) are essential as energy substrate for the myocardium, an excess of circulating NEFAs can be harmful. This study aimed to assess plausible relationships between serum NEFA and mortality due to cardiovascular disease (CVD) in individuals with CKD. Design, setting, participants, & measurements This was a prospective cohort study from the third examination cycle of the Uppsala LongitudinaL Study of Adult Men, a population-based survey of 1221 elderly men aged 70-71 years residing in Uppsala, Sweden. Data collection took place during 1991-1995. All participants had measures of kidney function; this study investigated 623 (51.7%) of these patients with manifest CKD (defined as either eGFR<60 ml/min per 1.73 m(2) or urine albumin excretion rate >= 20 mu g/min). Follow-up for mortality was done from examination date until death or December 31, 2007. After a median follow-up of 14 years (nterquartile range, 8-16.8), associations of NEFAs with mortality (related to all causes, CVD, ischemic heart disease [IHD], or acute myocardial infarction) were ascertained. Results The median serum NEFA was 14.1 mg/dl (interquartile range, 11.3-17.8). No association was found with measures of kidney function. Diabetes and serum triglycerides were the only multivariate correlates of NEFA. During follow-up, 453 participants died, of which 209 deaths were due to CVD, including 88 IHD deaths, with 41 attributed to acute myocardial infarction (AMI). In fully adjusted covariates, serum NEFA was an independent risk factor for all-cause mortality (hazard ratio [HR] per log(2) increase, 1.22; 95% confidence interval [95% CI], 1.00 to 1.48) and CVD-related death (HR, 1.51; 95% CI, 1.15 to 1.99), including both IHD (HR, 1.51; 95% CI, 1.00 to 2.32) and AMI mortality (HR, 2.08; 95% CI, 1.09 to 3.98). Conclusions Elevated serum NEFA associated with CVD mortality, and particularly with mortality due to AMI, in a homogeneous population of older men with moderate CKD.

  • 495.
    Xu, H.
    et al.
    Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, SE-14186 Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, SE-14186 Stockholm, Sweden..
    Rossi, M.
    Princess Alexandra Hosp, Ctr Kidney Dis Res, Brisbane, Qld 4102, Australia.;Kings Coll London, Div Diabet & Nutr Sci, London WC2R 2LS, England..
    Campbell, K. L.
    Princess Alexandra Hosp, Ctr Kidney Dis Res, Brisbane, Qld 4102, Australia.;Bond Univ, Fac Hlth Sci & Med, Robina, Australia..
    Sencion, G. L.
    Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, SE-14186 Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, SE-14186 Stockholm, Sweden..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden..
    Cederholm, Tommy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Sjögren, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Riserus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Lindholm, B.
    Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, SE-14186 Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, SE-14186 Stockholm, Sweden..
    Carrero, J. J.
    Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, SE-14186 Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, SE-14186 Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, SE-14186 Stockholm, Sweden..
    Excess protein intake relative to fiber and cardiovascular events in elderly men with chronic kidney disease2016In: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, E-ISSN 1590-3729, Vol. 26, no 7, p. 597-602Article in journal (Refereed)
    Abstract [en]

    Background and aims: The elevated cardiovascular (CVD) risk observed in chronic kidney disease (CKD) may be partially alleviated through diet. While protein intake may link to CVD events in this patient population, dietary fiber has shown cardioprotective associations. Nutrients are not consumed in isolation; we hypothesize that CVD events in CKD may be associated with dietary patterns aligned with an excess of dietary protein relative to fiber. Methods and Results: Prospective cohort study from the Uppsala Longitudinal Study of Adult Men. Included were 390 elderly men aged 70-71 years with CKD and without clinical history of CVD. Protein and fiber intake, as well as its ratio, were calculated from 7-day dietary records. Cardiovascular events were registered prospectively during a median follow-up of 9.1 (inter-quartile range, 4.5-10.7) years. The median dietary intake of protein and fiber was 66.7 (60.7-71.1) and 16.6 (14.5-19.1) g/day respectively and the protein-to-fiber intake ratio was 4.0 (3.5-4.7). Protein-to-fiber intake ratio was directly associated with serum C-reactive protein levels. During follow-up, 164 first-time CVD events occurred (incidence rate 54.5/1000 per year). Protein-fiber intake ratio was an independent risk factor for CVD events [adjusted hazard ratio, HR per standard deviation increase (95% confidence interval, CI) 1.33 (1.08, 1.64)]. Although in opposing directions, dietary protein [1.18 (0.97, 1.44)], dietary fiber alone [0.81 (0.64, 1.02)], were not significantly associated with CVD events. Conclusions: An excess of dietary protein relative to fiber intake was associated with the incidence of cardiovascular events in a homogeneous population of older men with CKD.

  • 496.
    Xu, H.
    et al.
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden..
    Sandhagen, Bo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Lindholm, B.
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Carrero, J. J.
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden..
    Lipophilic index, kidney function, and kidney function decline2016In: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, E-ISSN 1590-3729, Vol. 26, no 12, p. 1096-1103Article in journal (Refereed)
    Abstract [en]

    Background and aims: Unhealthy dietary fats are associated with faster kidney function decline. The cell membrane composition of phospholipid fatty acids (FAs) is a determinant of membrane fluidity and rheological properties. These properties, which have been linked to kidney damage, are thought to be reflected by the lipophilic index (LI). We prospectively investigated the associations of LI with kidney function and its decline. Methods and results: Observational study from the Prospective Investigation of Vasculature in Uppsala Seniors including 975 men and women with plasma phospholipid FAs composition and cystatin-C estimate glomerular filtration rate (eGFR). Of these, 780 attended reexamination after 5 years, and eGFR changes were assessed. Participants with a 5-year eGFR reduction >= 30% were considered chronic kidney disease (CKD) progressors (n = 198). LI was calculated as the sum of the products of the FA proportions with the respective FAs melting points. Blood rheology/viscosity measurements were performed in a random subsample of 559 subjects at baseline. Increased LI showed a statistically significant but overall weak association with blood, plasma viscosity (both Spearman rho = 0.16, p < 0.01), and erythrocyte deformability (rho = -0.09, p < 0.05). In cross-sectional analyses, LI associated with lower eGFR (regression coefficient 3.00 ml/min/1.73 m(2) 1-standard deviation (SD) increment in LI, 95% CI: -4.31, -1.69, p < 0.001). In longitudinal analyses, LI associated with a faster eGFR decline (-2.13 [95% CI -3.58, -0.69] ml/min/1.73 m(2), p < 0.01) and with 32% increased odds of CKD progression (adjusted OR 1.32 [95%, CI 1.05-1.65]). Conclusions: A high LI was associated with lower kidney function, kidney function decline, and CKD progression.

  • 497.
    Xu, Hong
    et al.
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Sjögren, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Ärnlov, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Banerjee, Tanushree
    Univ Calif, Div Gen Internal Med, Dept Med, Davis, CA USA..
    Cederholm, Tommy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Lindholm, Bengt
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Carrero, Juan Jesus
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Mediation Analysis of Pro-Inflammatory Diets and Kidney Function in Two Community-Based Cohorts of Elderly2015In: Nephrology, Dialysis and Transplantation, ISSN 0931-0509, E-ISSN 1460-2385, Vol. 30Article in journal (Other academic)
  • 498. Xu, Hong
    et al.
    Sjögren, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Banerjee, Tanushree
    Cederholm, Tommy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Lindholm, Bengt
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Carrero, Juan Jesus
    A Proinflammatory Diet Is Associated with Systemic Inflammation and Reduced Kidney Function in Elderly Adults2015In: Journal of Nutrition, ISSN 0022-3166, E-ISSN 1541-6100, Vol. 145, no 4, p. 729-735Article in journal (Refereed)
    Abstract [en]

    Background: Diet can affect kidney health through its effects on inflammation. Objective: We tested whether the Adapted Dietary Inflammatory Index (ADII) is associated with kidney function and whether effects of diet on chronic low-grade inflammation explain this association. Methods: This was an observational analysis in 1942 elderly community-dwelling participants aged 70-71 y from 2 independent cohorts: the Uppsala Longitudinal Study of Adult Men (n = 1097 men) and the Prospective Investigation of Vasculature in Uppsala Seniors (n = 845 men and women). The ADII was calculated from 7-d food records, combining putatively proinflammatory and anti-inflammatory effects of nutrients, vitamins, and trace elements. The ADII was validated against serum C-reactive protein (CRP) concentrations. The estimated glomerular filtration rate (eGFR) was assessed from serum cystatin C (cys) and creatinine (crea). Associations between the ADII and eGFR were investigated, and CRP was considered to be a mediator. Results: In adjusted analysis, a 1-SD higher ADII was associated with higher CRP (beta: 6%, 95% Cl: 1%, 10%; P= 0.01) and lower eGFR [Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)(cys): -2.1%, 95% Cl: -3.2%, -1.1%; CKD-EPi(cys+crea): -1.8%; 95% Cl: -2.7%, -0.9%; both P < 0.001]. CRP was also inversely associated with eGFR. Mediation analyses showed that of the total effect of the ADII on kidney function, 15% and 17% (for CKD-EPIcys+crea and CKD-EPIcys equations, respectively) were explained/mediated by serum CRP. Findings were similar when each cohort was analyzed separately. Conclusions: A proinflammatory diet was associated with systemic inflammation as well as with reduced kidney function in a combined analysis of 2 community-based cohorts of elderly individuals. Our results also suggest systemic inflammation to be one potential pathway through which this dietary pattern is linked to kidney function.

  • 499.
    Xu, Hong
    et al.
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Xiong, Zibo
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Huang, Xiaoyan
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Ärnlov, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Qureshi, Abdul Rashid
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Cederholm, Tommy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Sjögren, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Lindholm, Bengt
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Carrero, Juan Jesus
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Non-Esterified Fatty Acids and Cardiovascular Mortality in Elderly Men with Chronic Kidney Disease2015In: Nephrology, Dialysis and Transplantation, ISSN 0931-0509, E-ISSN 1460-2385, Vol. 30Article in journal (Other academic)
  • 500.
    Xu, Hong
    et al.
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Xiong, Zibo
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Ärnlov, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Cederholm, Tommy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Sjögren, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Lindholm, Bengt
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Carrero, Juan Jesus
    Karolinska Inst, Div Renal Med, Stockholm, Sweden.;Karolinska Inst, Div Baxter Novum, Stockholm, Sweden..
    Circulating Alpha-Tocopherol and Insulin Sensitivity Among Elderly Men with Chronic Kidney Disease2015In: Nephrology, Dialysis and Transplantation, ISSN 0931-0509, E-ISSN 1460-2385, Vol. 30Article in journal (Other academic)
7891011 451 - 500 of 514
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