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  • 51.
    Reutfors, Johan
    et al.
    Karolinska Inst, Dept Med, Ctr Pharmacoepidemiol, Stockholm, Sweden..
    Bahmanyar, Shahram
    Karolinska Inst, Dept Med, Ctr Pharmacoepidemiol, Stockholm, Sweden..
    Brandt, Lena
    Karolinska Inst, Dept Med, Ctr Pharmacoepidemiol, Stockholm, Sweden..
    Clapham, Eric
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Jönsson, Erik G.
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Boden, Robert
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital. Karolinska Inst, Dept Med, Ctr Pharmacoepidemiol, Stockholm, Sweden..
    Ekbom, Anders
    Karolinska Inst, Dept Med, Ctr Pharmacoepidemiol, Stockholm, Sweden..
    Osby, Urban
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
    Suicide Risk and Side Effects from Antipsychotics in Schizophrenia: A Nested Case-Control Study2015In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 24, p. 333-333Article in journal (Other academic)
  • 52. Reutfors, Johan
    et al.
    Brandt, Lena
    Stephansson, Olof
    Kieler, Helle
    Andersen, Morten
    Boden, Robert
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Antipsychotic Medication Adherence in Patients with Schizophrenia or Schizoaffective Disorder2012In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 21, no SI:3, p. 437-438Article in journal (Other academic)
  • 53. Reutfors, Johan
    et al.
    Tiihonen, Jari
    Brandt, Lena
    Scheen, Louise
    Tanskanen, Antti
    Andersen, Morten
    Boden, Robert
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Medication and Risk of Rehospitalization in Bipolar Disorder: A Nationwide Cohort Study2014In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 23, no S1, p. 251-251Article in journal (Other academic)
  • 54.
    Ring, Lena
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    Bardage, Carola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    Ekedahl, Anders
    Patient's Views on Multi-Dose Dispensed Medicines2013In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 22, no S1, p. 463-464Article in journal (Other academic)
  • 55. Rodriguez, LAG
    et al.
    Wallander, Mari-Ann
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Martin-Merino, Elisa
    Johansson, Saga
    Heart failure, myocardial infarction and lung cancer in patients with chronic obstructive pulmonary disease2009In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 18, no Suppl. 1, p. S49-S50Article in journal (Refereed)
  • 56. Scheen, Louise
    et al.
    Boden, Robert
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Brandt, Lena
    Tiihonen, Jari
    Andersen, Morten
    Kieler, Helle
    Reutfors, Johan
    Clinical Factors Associated with Prescription Filling of Mood-Stabilizers in Bipolar Disorder - A Population-Based Cohort Study2014In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 23, no S1, p. 368-369Article in journal (Other academic)
  • 57.
    Sohrabian, Donia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Linder, Marie
    Karolinska Inst, Med, Stockholm, Sweden..
    Ekstrand, Charlotta
    Karolinska Inst, Med, Stockholm, Sweden..
    Cherif, Honar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
    Kieler, Helle
    Karolinska Inst, Med, Stockholm, Sweden..
    Bahmanyar, Shahram
    Karolinska Inst, Med, Stockholm, Sweden..
    Infection and Anti-Infective Treatment Preceding a Diagnosis of Primary Persisting Immune Thrombocytopenia2016In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 25, no Suppl. 3, p. 88-88, article id Abstr. 143Article in journal (Refereed)
  • 58.
    Star, Kristina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences. Uppsala Monitoring Ctr, Res Sect, Uppsala, Sweden.
    Sandberg, Lovisa
    Uppsala Monitoring Ctr, Res Sect, Uppsala, Sweden.
    Bergvall, Tomas
    Uppsala Monitoring Ctr, Res Sect, Uppsala, Sweden.
    Choonara, Imti
    Univ Nottingham, Div Med Sci & Grad Entry Med, Derby, England.
    Caduff-Janosa, Pia
    Uppsala Monitoring Ctr, Res Sect, Uppsala, Sweden.
    Edwards, I. Ralph
    Uppsala Monitoring Ctr, Res Sect, Uppsala, Sweden.
    Paediatric safety signals identified in VigiBase: Methods and results from Uppsala Monitoring Centre2019In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 28, no 5, p. 680-689Article in journal (Refereed)
    Abstract [en]

    Purpose: The purpose of this study is to uncover previously unrecognised risks of medicines in paediatric pharmacovigilance reports and thereby advance a safer use of medicines in paediatrics. Methods: Individual case safety reports (ICSRs) with ages less than 18 years were retrieved from VigiBase, the World Health Organization (WHO) global database of ICSRs, in September 2014. The reports were grouped according to the following age spans: 0 to 27 days; 28 days to 23 months; 2 to 11 years; and 12 to 17 years. vigiRank, a data-driven predictive model for emerging safety signals, was used to prioritise the list of drug events by age groups. The list was manually assessed, and potential signals were identified to undergo in-depth assessment to determine whether a signal should be communicated. Results: A total of 472 drug-event pairs by paediatric age groups were the subject of an initial manual assessment. Twenty-seven drug events from the two older age groups were classified as potential signals. An in-depth assessment resulted in eight signals, of which one concerned harm in connection with off-label use of dextromethorphan and another with accidental overdose of olanzapine by young children, and the remaining signals referred to potentially new causal associations for atomoxetine (two signals), temozolamide, deferasirox, levetiracetam, and desloratadine that could be relevant also for adults. Conclusions: Clinically relevant signals were uncovered in VigiBase by using vigiRank applied to paediatric age groups. Further refinement of the methodology is needed to identify signals in reports with ages under 2 years and to capture signals specific to the paediatric population as a risk group.

  • 59.
    Star, Kristina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Health Services Research. Uppsala Monitoring Ctr, WHO Collaborating Ctr Int Drug Monitoring, Uppsala, Sweden.
    Sandberg, Lovisa
    Uppsala Monitoring Ctr, WHO Collaborating Ctr Int Drug Monitoring, Uppsala, Sweden..
    Choonara, Imti
    Univ Nottingham, Derbyshire Childrens Hosp, Sch Med, Div Med Sci & Grad Entry Med, Derby, England..
    Caduff, Pia
    Uppsala Monitoring Ctr, WHO Collaborating Ctr Int Drug Monitoring, Uppsala, Sweden..
    Edwards, I. Ralph
    Uppsala Monitoring Ctr, WHO Collaborating Ctr Int Drug Monitoring, Uppsala, Sweden..
    First Time Signal Detection of Global Paediatric Data - Putting Theory into Practice2016In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 25, no Suppl. 3, p. 68-68, article id Abstr. 109Article in journal (Refereed)
  • 60.
    Star, Kristina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences.
    Strandell, Johanna
    Friden, Sarah
    Sallstedt, Lovisa
    Johansson, Jeanette
    Edwards, Ralph I.
    Temporal Pattern Discovery on Electronic Health Records - A Source of Reference in Signal Detection Work2012In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 21, no SI:3, p. 347-347Article in journal (Other academic)
  • 61.
    Watson, Sarah
    et al.
    WHO Collaborating Ctr Int Drug Monitoring, Uppsala Monitoring Ctr, Uppsala, Sweden.
    Taavola, Henric
    WHO Collaborating Ctr Int Drug Monitoring, Uppsala Monitoring Ctr, Uppsala, Sweden.
    Chandler, Rebecca
    WHO Collaborating Ctr Int Drug Monitoring, Uppsala Monitoring Ctr, Uppsala, Sweden.
    Harmark, Linda
    WHO Collaborating Ctr Pharmacovigilance Educ & Pa, Netherlands Pharmacovigilance Ctr Lareb, sHertogenbosch, Netherlands.
    van Hunsel, Florence
    WHO Collaborating Ctr Pharmacovigilance Educ & Pa, Netherlands Pharmacovigilance Ctr Lareb, sHertogenbosch, Netherlands.
    Zekarias, Alem
    WHO Collaborating Ctr Int Drug Monitoring, Uppsala Monitoring Ctr, Uppsala, Sweden.
    Grundmark, Birgitta
    WHO Collaborating Ctr Int Drug Monitoring, Uppsala Monitoring Ctr, Uppsala, Sweden.
    Star, Kristina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences. WHO Collaborating Ctr Int Drug Monitoring, Uppsala Monitoring Ctr, Uppsala, Sweden.
    Exploring Patient Reported Information in Signal Detection within a Global Database2017In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 26, p. 316-317Article in journal (Other academic)
  • 62. Weitoft, Gunilla Ringback
    et al.
    Berglund, Mats
    Lindström, Eva A.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Nilsson, Mikael
    Salmi, Peter
    Rosen, Mans
    Mortality, attempted suicide, re-hospitalisation and prescription refill for clozapine and other antipsychotics in Sweden-a register-based study2014In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 23, no 3, p. 290-298Article in journal (Refereed)
    Abstract [en]

    Purpose: The aim of this study was to analyse prescription refill, re-hospitalisation, total mortality, mortality because of suicide and attempted suicide among patients who were taking various types of antipsychotics. Methods: A population-based cohort study analysed all patients (n=26046) in Sweden who had been treated for schizophrenia from 2006 to 2009 with regard to re-hospitalisation and prescription refill for various types of antipsychotic treatment. A case-control study nested within the cohort analysed all-cause mortality, mortality because of suicide and attempted suicide in relation to antipsychotic use. The study adjusted for history of hospitalisation for psychiatric and medical care, attempted suicide and use of antidepressants. Results: Aripiprazole users were the only ones who showed significantly lower all-cause risks of death, but so few events occurred among users of this relatively new drug that the results should be interpreted with caution. Clozapine users showed lower odds of death by suicide (odds ratio [OR]=0.45 [95%CI 0.20-0.98]) and of attempted suicide (OR=0.44 [0.28-0.70]) than haloperidol users after adjustment for age, sex and year of discharge. Olanzapine users showed approximately the same favourable pattern. Patients who used clozapine were most likely to refill prescriptions and had lower rates of re-hospitalisation. Only one death and 23 cases of agranulocytosis were reported compared with 223 suicides and 831 suicide attempts. An etiologic fraction calculation suggests that the use of clozapine rather than traditional drugs could have prevented 95 suicide attempts during the period. Conclusion: Clozapine and olanzapine reduce the risk of suicide, attempted suicide and re-hospitalisation.

  • 63. Wettermark, Björn
    et al.
    Pehrsson, Åke
    Juhasz-Haverinen, Maria
    Vég, Anikó
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Health Services Research.
    Edlert, Maria
    Törnwall-Bergendahl, Gunilla
    Almkvist, Henrik
    Godman, Brian
    Bergman, Ulf
    Improving the Quality and Efficiency of Drug Prescribing in Primary Care by Means of Financial Incentives2009In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 18, no S1, p. S261-S261Article in journal (Other academic)
  • 64.
    Whichello, Chiara
    et al.
    Erasmus Univ, Rotterdam, Netherlands.
    Schölin Bywall, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics.
    Mauer, Jonathan
    Pfizer Inc, New York, NY USA.
    Watt, Stephen J.
    Pfizer Inc, New York, NY USA.
    Cleemput, Irina
    KCE Belgian Healthcare Knowledge Ctr, Brussels, Belgium.
    Anne, Cathy
    Merck & Co Inc, Kenilworth, NJ USA.
    van Overbeeke, Eline
    Katholieke Univ Leuven, Leuven, Belgium.
    Huys, Isabelle
    Katholieke Univ Leuven, Leuven, Belgium.
    Janssens, Rosanne
    Katholieke Univ Leuven, Leuven, Belgium.
    Hermann, Richard
    AstraZeneca, Gaithersburg, MD USA.
    Veldwijk, Jorien
    Erasmus Univ, Rotterdam, Netherlands.
    Mapping benefit-risk decision-making processes and identifying decision points with the potential to include patient preference information throughout the medical product lifecycle2018In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 27, no Suppl. 2, p. 206-206, article id 443Article in journal (Other academic)
  • 65.
    Whichello, Chiara
    et al.
    Erasmus Univ, Rotterdam, Netherlands.
    Soekhai, Vikas
    Erasmus Univ, Rotterdam, Netherlands.
    Levitan, Bennett
    Janssen R&D, Titusville, NJ USA.
    Veldwijk, Jorien
    Erasmus Univ, Rotterdam, Netherlands.
    Hammad, Tarek
    EMD Serono Res & Dev, Billerica, MA USA.
    Kihlbom, Ulrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics.
    van Overbeeke, Eline
    Katholieke Univ Leuven, Leuven, Belgium.
    Russo, Selena
    European Inst Oncol, Milan, Italy.
    Mohammed, Ateesha
    Bayer, Whippany, NJ USA.
    Hermann, Richard
    AstraZeneca, Wilmington, DE USA.
    Huys, Isabelle
    Katholieke Univ Leuven, Leuven, Belgium.
    Patadia, Vaishali
    Sanofi, Bridgewater, NJ USA.
    Juhaeri, Juhaeri
    Sanofi, Bridgewater, NJ USA.
    de Bekker-Grob, Esther
    Erasmus Univ, Rotterdam, Netherlands.
    Compendium of methods for measuring patient preferences in medical treatment2018In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 27, no Suppl. 2, p. 517-518, article id 1135Article in journal (Other academic)
  • 66. Ylinen, Sanna
    et al.
    Hameen-Anttila, Katri
    Sepponen, Kati
    Kettis, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    Ahonen, Riitta
    The use of prescription medicines and self-medication among children: a population-based study in Finland2010In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 19, no 10, p. 1000-1008Article in journal (Refereed)
    Abstract [en]

    Purpose The aim of this study was to investigate the prevalence and concomitant use of prescription medicines and self-medication, including over-the-counter (OTC) medicines, vitamins, and complementary and alternative medicines (CAMs) among Finnish children aged under 12 years. Methods We carried out a nationwide postal survey of the use of medicines by a representative sample (n = 6000) of Finnish children aged under 12 years in spring 2007. A response rate of 67% (n = 4032) was achieved. The current use of prescription medicines and the use of OTC medicines, vitamins, and CAMs in the preceding 2 days were the main outcome measures. Results In total, 17% of children had used prescription medicines and 50% some self-medication. The corresponding figures for OTC medicines, vitamins, and CAMs use were 17, 37, and 11%, respectively. Drugs for obstructive airway diseases were the most common prescription medicines, whereas analgesics and antipyretics, including non-steroidal-anti-inflammatory-medicines (NSAID), were the most common OTC medicines reported. Vitamin D was the most common vitamin, while fish oils and fatty acids were the most common CAMs used. Ten percent of the children had used prescription medicines and self-medication concomitantly. Conclusions Most of the children's medication consists of self-medication, and especially of vitamin use. However, also a considerable proportion had used prescription medicines, and a minority prescription medicines and self-medication concomitantly. In three of the cases, a combination of prescription and OTC medicine with a potential risk for interactions were found. Physicians should be aware of this wide use of self-medication when prescribing medicines. Copyright (C) 2010 John Wiley & Sons, Ltd.

12 51 - 66 of 66
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