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  • 51.
    Kalm-Stephens, Pia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Nordvall, Lennart
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Alving, Kjell
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Airway responsiveness and inflammatory markers in non-asthmatic adolescents with elevated FeNO2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 52.
    Krantz, Christina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Alving, Kjell
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Longitudinal changes in exhaled and nasal nitric oxide in children and young adults with asthma2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 53.
    Kuiper, Ingrid Nordeide
    et al.
    Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
    Svanes, Cecilie
    Haukeland Hosp, Dept Occupat Med, Bergen, Norway; Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway.
    Abramson, Michael J.
    Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
    Benediktsdottir, Bryndis
    Univ Iceland, Fac Med, Reykjavik, Iceland.
    Bertelsen, Randi J.
    Univ Bergen, Dept Clin Sci, Bergen, Norway.
    Dennekamp, Martine
    Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
    Forsberg, Bertil
    Umeå Univ, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, Umeå, Sweden.
    Gislason, Thorarinn
    Univ Iceland, Fac Med, Reykjavik, Iceland; Landspitali Univ Hosp Reykjavik, Dept Resp Med & Sleep, Reykjavik, Iceland.
    Halvorsen, Thomas
    Univ Bergen, Dept Clin Sci, Bergen, Norway; Haukeland Hosp, Dept Pediat, Bergen, Norway.
    Heinrich, Joachim
    Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany; Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, Munich, Germany.
    Holm, Mathias
    Univ Gothenburg, Dept Occupat & Environm Med, Gothenburg, Sweden; Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Jogi, Rain
    Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Marcon, Alessandro
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Markevych, Iana
    Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany; Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, Munich, Germany.
    Moratalla, Jesus M.
    Serv Salud Castilla, La Mancha, Albacete, Spain.
    Oudin, Anna
    Umeå Univ, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, Umeå, Sweden; Lund Univ, Div Occupat & Environm Med, Umeå, Sweden.
    Pearce, John L.
    Med Univ South Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA.
    Schlunssen, Vivi
    Aarhus Univ, Dept Publ Hlth, Sect Environm Occupat & Hlth, Danish Ramazzini Ctr, Aarhus, Denmark; Natl Res Ctr Working Environm, Aarhus, Denmark.
    Vega, Antonio P.
    Univ Hosp Complex, Resp & Allergy Clin Unit, Huelva, Spain.
    Johannessen, Ane
    Haukeland Hosp, Dept Occupat Med, Bergen, Norway; Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway.
    Lung health in adulthood after childhood exposure to air pollution and greenness2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 54. Lamprecht, Bernd
    et al.
    Vanfleteren, Lowie E.
    Studnicka, Michael
    Allison, Michael
    McBurnie, Mary Ann
    Vollmer, William M.
    Tan, Wan Cheng
    Nielsen, Rune
    Nastalek, Pawel
    Gnatiuc, Louisa
    Kaiser, Bernhard
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
    Wouters, Emiel F. M.
    Burney, Peter
    Buist, A. Sonia
    Sex-related differences in respiratory symptoms: results from the BOLD Study2013In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 42, no 3, p. 858-860Article in journal (Refereed)
  • 55. Larsson, Lars
    et al.
    Boethius, Göran
    Uddenfeldt, Monica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy.
    Differences in utilization of asthma drugs between two neighbouring Swedish provinces: relation to symptom reporting1993In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 6, p. 198-203Article in journal (Refereed)
  • 56. Le Moual, Nicole
    et al.
    Carsin, Anne-Elie
    Siroux, Valerie
    Radon, Katja
    Norbäck, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Toren, Kjell
    Olivieri, Mario
    Urrutia, Isabel
    Cazzoletti, Lucia
    Jacquemin, Benedicte
    Benke, Geza
    Kromhout, Hans
    Mirabelli, Maria C.
    Mehta, Amar J.
    Schluenssen, Vivi
    Sigsgaard, Torben
    Blanc, Paul D.
    Kogevinas, Manolis
    Anto, Josep M.
    Zock, Jan-Paul
    Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II2014In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 43, no 2, p. 374-386Article in journal (Refereed)
    Abstract [en]

    Occupational exposure is a well-recognised modifiable risk factor for asthma, but the relationship between occupational exposure and asthma control has not been studied. We aimed to study this association among working-age adults from the European Community Respiratory Health Survey (ECRHS). Data were available for 7077 participants (mean age 43 years, 45% never-smokers, 5867 without asthma and 1210 with current asthma). Associations between occupational exposure to specific asthmagens and asthma control status (33% with uncontrolled asthma, based on the Global Initiative for Asthma guidelines) were evaluated using logistic and multinomial regressions, adjusted for age, sex and smoking status, with study areas included as a random effect. Statistically significant positive associations were observed between uncontrolled adult-onset asthma and both past 12-month and 10-year exposure to any occupational asthmagens (OR (95% CI) 1.6 (1.0-2.40) and 1.7 (1.2-2.5), respectively); high (1.7 (1.0-2.8) and 1.9 (1.3-2.9), respectively) and low (1.6 (1.0-2.7) and 1.8 (1.2-2.7), respectively) molecular weight agents; and cleaning agents (2.0 (1.1-3.6) and 2.3 (1.4-3.6), respectively), with stronger associations for long-term exposures. These associations were mainly explained by the exacerbation domain of asthma control and no associations were observed between asthmagens and partly controlled asthma. These findings suggest that occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma. Occupational risk factors should be quickly identified to prevent uncontrolled asthma.

  • 57.
    Lindh, Annika
    et al.
    Örebro Univ, Fac Med & Hlth, Sch Hlth Sci, Örebro, Sweden; Cty Council Värmland, Clin Res Ctr, Karlstad, Sweden.
    Theander, Kersti
    Cty Council Värmland, Clin Res Ctr, Karlstad, Sweden.
    Arne, Mats
    Cty Council Värmland, Clin Res Ctr, Karlstad, Sweden.
    Lisspers, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Lundh, Lena
    Acad Primary Hlth Care Ctr, Stockholm, Sweden; Karolinska Inst, Div Family Med & Primary Care, NVS, Stockholm, Sweden.
    Sandelowsky, Hanna
    Acad Primary Hlth Care Ctr, Stockholm, Sweden; Karolinska Inst, Div Family Med & Primary Care, NVS, Stockholm, Sweden.
    Ställberg, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Adolfsson, Eva Thors
    Reg Västmanland, Primary Hlth Care, Västerås, Sweden.
    Westerdahl, Elisabeth
    Örebro Univ, Fac Med & Hlth, Sch Hlth Sci, Örebro, Sweden.
    Zakrisson, Ann-Britt
    Örebro Univ, Fac Med & Hlth, Univ Healthcare Res Ctr, Örebro, Sweden.
    Description of inhalation technique in patients with COPD in primary care2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 58.
    LoMauro, Antonella
    et al.
    Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy.
    Aliverti, Andrea
    Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy.
    Alberigo, Daniela
    Osped Maggiore Policlin Fo Milan, Fdn IRCCS Ca Granda, Departiment Obstet & Gynecol L Mangiagalli, Milan, Italy.
    Persico, Nicola
    Osped Maggiore Policlin Fo Milan, Fdn IRCCS Ca Granda, Departiment Obstet & Gynecol L Mangiagalli, Milan, Italy.
    Frykholm, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Briganti, Federica
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pneumol Unit, Milan, Italy.
    Nosotti, Mario
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Thorac Surg & Lung Transplant Unit, Milan, Italy.
    Righi, Ilaria
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Thorac Surg & Lung Transplant Unit, Milan, Italy.
    The Effect Of Pregnancy On Respiratory Function2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 59.
    LoMauro, Antonella
    et al.
    Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy.
    Aliverti, Andrea
    Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy.
    Privitera, Emilia
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Thorac Surg & Lung Transplant Unit, Milan, Italy.
    Vergari, Maurizio
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Clin Ctr Neurostimulat Neurotechnol & Movement Di, Milan, Italy.
    Righi, Ilaria
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Thorac Surg & Lung Transplant Unit, Milan, Italy.
    Sgroia, Manuela
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Thorac Surg & Lung Transplant Unit, Milan, Italy.
    Tosi, Davide
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Thorac Surg & Lung Transplant Unit, Milan, Italy.
    Rossetti, Valeria
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pneumol Unit, Milan, Italy.
    Briganti, Federica
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pneumol Unit, Milan, Italy.
    Frykholm, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Colombo, Carla
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pediat Cyst Fibrosis Unit, Milan, Italy.
    Nosotti, Mario
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Thorac Surg & Lung Transplant Unit, Milan, Italy.
    Palleschi, Alessandro
    Fdn IRCCS Ca Granda Osped Maggiore Policlin, Thorac Surg & Lung Transplant Unit, Milan, Italy.
    The diaphragm before and after lung transplant (LT)2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 60.
    LoMauro, Antonella
    et al.
    Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy.
    Johansson, Henrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiotherapy. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Frykholm, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Mallmin, Elisabet
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
    Norlander, Katarina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
    Aliverti, Andrea
    Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy.
    Nordang, Leif
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
    The ventilatory pattern and the operational volumes during exercise in subjects with diagnosed exercise-induced laryngeal obstruction (EILO)2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 61.
    Lønnebotn, Marianne
    et al.
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
    Nilsen, Roy Miodini
    Bergen Univ Coll, Dept Nursing, Bergen, Norway.
    Dharmage, Shyamali
    Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia.
    Franklin, Karl A.
    Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.
    Holm, Mathias
    Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Jarvis, Debbie
    Imperial Coll London, Populat Hlth & Occupat Dis, Natl Heart & Lung Inst, London, England.
    Johannessen, Ane
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
    Kirkeleit, Jorunn
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Schlünssen, Vivi
    Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.
    Svanes, Cecilie
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway.
    Real, Francisco Gomez
    Univ Bergen, Dept Clin Sci, Bergen, Norway.
    Late Breaking Abstract - Associations of fathers and their offsprings weight gain with non-allergic asthma2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 62.
    Malinovschi, Andrei
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Bröms, Kristina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
    Ställberg, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Lisspers, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Högman, Marieann
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Clinical clustering of COPD patients is useful to predict future COPD exacerbations2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 63.
    Malinovschi, Andrei
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrative Physiology.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
    Holmkvist, Thomas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrative Physiology.
    Norbäck, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Meriläinen, P.
    Högman, Marieann
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrative Physiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
    Effect of smoking on exhaled nitric oxide and flow-independent nitric oxide exchange parameters2006In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 28, no 2, p. 339-345Article in journal (Refereed)
    Abstract [en]

    It is a well-known fact that smoking is associated with a reduction in exhaled nitric oxide (NO) levels. There is, however, limited knowledge relating to the smoking-induced changes in production or exchange of NO in different compartments of the airways. This study comprised 221 adult subjects from the European Community Respiratory Health Survey 11, who were investigated in terms of their exhaled NO, lung function, immunoglobulin E sensitisation and smoking habits. The following parameters were determined using extended NO analysis: airway tissue nitric oxide concentration (Caw,NO), airway transfer factor (or diffusing capacity) for nitric oxide (Daw,NO), alveolar nitric oxide concentration (CA,No) and fractional exhaled nitric oxide concentration at a flow rate of 50 mL(.)s(-1) (FeNO,0.05). Maximum total airway nitric oxide flux (J'aw,NO) was calculated from Daw,NO(Caw,NO-CA,NO). Current smokers (n=35) exhibited lower (geometric mean) FeNO,0.05 (14.0 versus 22.8 ppb), Caw,NO (79.0 versus 126 ppb) and J'aw,NO (688 versus 1,153 pL(.)s(-1)) than never-smokers (n=111). Ex-smokers (n=75) were characterised by lower FeNO,0.05 (17.7 versus 22.8 ppb) and Jaw,NO (858 versus 1,153 pL-s(-1)) than never-smokers. These relationships were maintained after adjusting for potential confounders (sex, age, height, immunoglobulin E sensitisation and forced expiratory volume in one second), and, in this analysis, a negative association was found between current smoking and CA,NO. Snus (oral moist snuff) consumption (n=21) in ex-smokers was associated with an increase in Daw,NO and a reduction in Caw,No, after adjusting for potential confounders. Passive smoking was associated with a higher CA,NO. Using extended nitric oxide analysis, it was possible to attribute the reduction in exhaled nitric oxide levels seen in ex- and current smokers to 6 lower total airway nitric oxide flux in ex-smokers and reduced airway and alveolar nitric oxide concentrations in current smokers. The association between snus (oral tobacco) use and reduced nitric oxide concentrations in the airways and increased nitric oxide transfer from the airways warrants further studies.

  • 64.
    Marcon, Alessandro
    et al.
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Marchetti, Pierpaolo
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Anto, Josep M.
    Inst Salud Global Barcelona, Barcelona, Spain.
    Cazzoletti, Lucia
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Cerveri, Isa
    IRCCS San Matteo Hosp Fdn, Pavia, Italy.
    Corsico, Angelo
    IRCCS San Matteo Hosp Fdn, Pavia, Italy.
    Garcia-Aymerich, Judith
    Inst Salud Global Barcelona, Barcelona, Spain.
    Heinrich, Joachim
    Ludwig Maximilians Univ Munchen, Univ Hosp, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.
    Gislason, David
    Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland.
    Jogi, Rain
    Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
    Johannessen, Ane
    Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
    Leynaert, Benedicte
    Univ Paris Diderot Paris, INSERM, UMR Pathophysiol & Epidemiol Resp Dis 1152, Paris, France.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Pin, Isabelle
    Ctr Hosp Univ Grenoble Alpes, Grenoble, France; INSERM, Inst Adv Biosci, Grenoble, France.
    Weyler, Joost
    Univ Antwerp, Epidemiol & Social Med, Antwerp, Belgium.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Accordini, Simone
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Jarvis, Deborah
    Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.
    Inhaled corticosteroids and FEV1 decline in asthma: an international cohort study2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 65.
    Masefield, Sarah
    et al.
    European Lung Fdn, 442 Glossop Rd, Sheffield S10 2PX, S Yorkshire, England..
    Edwards, Jessica
    Asthma UK, London, England..
    Hansen, Kjeld
    Uppsala Univ, European Lung Fdn, Uppsala, Sweden..
    Hamerlijnck, Dominique
    Uppsala Univ, European Lung Fdn, Uppsala, Sweden..
    Lisspers, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    van der Schee, Marc
    Univ Amsterdam, Paediat Resp Med, Acad Med Ctr, Amsterdam, Netherlands..
    Silva, Liliana
    Matosinhos Local Hlth Unit, Commun Care Unit, Matosinhos, Portugal..
    Matthews, John
    Genentech Inc, 460 Point San Bruno Blvd, San Francisco, CA 94080 USA..
    Gaga, Mina
    Athens Chest Hosp, Dept Resp Med 7, Athens, Greece..
    Adcock, Ian
    Imperial Coll London, Thorac Med, London, England..
    Holgate, Stephen
    Southampton Gen Hosp, Fac Med, Southampton, Hants, England..
    Walker, Samantha
    Asthma UK, London, England..
    Powell, Pippa
    European Lung Fdn, 442 Glossop Rd, Sheffield S10 2PX, S Yorkshire, England..
    The future of asthma research and development: a roadmap from the European Asthma Research and Innovation Partnership (EARIP)2017In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 49, no 5, article id 1602295Article in journal (Refereed)
    Abstract [en]

    A coordinated European multi-stakeholder approach to asthma research Asthma is highly prevalent and associated with high morbidity and mortality. It affects 30-50 million people in Europe, often starting in infancy and persisting throughout life. Asthma is a major global health challenge, affecting more than 300 million people worldwide and at least 10% of all Europeans [1]. People with asthma live at risk of life-threatening asthma attacks, leading to over 500 000 hospitalisations each year. Approximately 5-10% of asthma cases are so severe that current treatments do not work. The Framework Programme 7-funded European Asthma Research and Innovation Partnership (EARIP; www.EARIP.eu) was established in 2013 to harmonise efforts to reduce mortality and morbidity from asthma by agreeing the most important research priorities across relevant stakeholders in Europe. This is essential to address the significant impact of asthma on the individual, healthcare systems and national and European economies, outlined in the accompanying editorial in this issue of the European Respiratory Journal [2]. EARIP produced an evidence- and consensus-based list of the research priorities (a "roadmap") and investment needed to reduce asthma deaths and hospitalisations. By identifying the priorities, a coordinated effort can be made to fast-track change to better manage, prevent and cure asthma [3]. The roadmap will be the foundation on which future EU, national and international research funding programmes can transform asthma outcomes throughout Europe. The roadmap is the product of a comprehensive multi-stage process, led by the European Lung Foundation and Asthma UK (figure 1) [4]. Multiple stakeholder groups informed the roadmap process to ensure scientific accuracy, clinical relevance and outcomes that reflect the priorities of patients and caregivers, with an overarching steering board. A final consensus workshop brought together 28 experts from 15 European countries comprising: patients, patient organisations, primary healthcare professionals (HCPs), secondary HCPs, researchers, industry representatives and policy influencers. A full list of the roadmap contributors is available at www.EARIP.eu/roadmap. The rest of this article describes its development and outcomes.

  • 66. Modig, Lars
    et al.
    Torén, K.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
    Järvholm, B.
    Forsberg, B.
    Vehicle exhaust outside the home and onset of asthma among adults2009In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 33, no 6, p. 1261-1267Article in journal (Refereed)
    Abstract [en]

    Few studies have investigated the relationship between vehicle exhaust and the new onset of asthma among adults. The aim of the present prospective cohort study was to investigate the relationship between the cumulative incidence of asthma and onset of asthma among adults and vehicle exhaust concentrations at home. Participants from three Swedish cities included in the Respiratory Health in Northern Europe cohort constituted the study population. Exposure at each participant's home was calculated using dispersion models. We also used <50 m distance to nearest major road as a more simple indicator of exposure. The adjusted model included 3,609 participants, of which 107 were classified as onset cases and 55 as true incident cases of asthma. There was a positive association between asthma onset (odds ratio (OR) per 10 microg x m(-3) 1.46, 95% confidence interval (CI) 1.07-1.99) and incident asthma (OR per 10 microg x m(-3) 1.54, 95% CI 1.00-2.36) and the levels of nitrogen dioxide (NO(2)), which remained statistically significant after adjusting for potential confounders. The relationship between asthma and NO(2) was not significantly modified by sex, hay fever or wheeze. The risk of developing asthma was also significantly related to living close to a major road. The current study suggests that elevated levels of vehicle exhaust outside the home increase the risk of onset and incident asthma among adults.

     

     

     

     

  • 67.
    Nerpin, Elisabet
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Jarvis, Debbie
    Imperial Coll, Natl Heart & Lung Inst, London, England.
    Olivieri, Mario
    Univ Verona, Dept Publ Hlth & Community Med, Unit Occupat Med, Verona, Italy.
    Gislason, Thorarinn
    Landspitali Univ Hosp, Dept Resp Med & Sleep, Reykjavik, Iceland.
    Olin, Anna-Carin
    Inst Med, Sect Occupat & Environm Med, Gothenburg, Sweden.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Different relation between exhaled nitric oxide and lung function with regard to current smoking2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 68.
    Nerpin, Elisabet
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Joao, Fonseca A.
    Univ Porto, Ctr Hlth Technol & Serv Res, Fac Med, Porto, Portugal.
    Jacinto, Tiago
    Univ Porto, Dept Biostat & Med Informat, Fac Med, Porto, Portugal.
    Alving, Kjell
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Blood cell counts and C-reactive protein in relation to lung function in NHANES 2007-20102018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 69.
    Nilsson, Kristina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Wollmer, P
    Pulmonary clearance of tracers with different lipid and water solubility in experimental surfactant dysfunction.1993In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 6, no 4, p. 505-8Article in journal (Refereed)
    Abstract [en]

    We measured the pulmonary clearance of inhaled 99mTc-diethylenetriamine penta-acetic acid (DTPA), 99mTc-sestamibi and 99mTc-dimethyliminodiacetic acid (HIDA) in normal rabbits, and rabbits with surfactant dysfunction induced by the detergent dioctyl sodium sulfosuccinate. The tracers differ widely in lipid/water partition coefficients, but have similar molecular radius and weight. Five animals in each group received the detergent in aerosol, and the other five a vehicle aerosol, before the administration of the tracer. Pulmonary clearance of the tracers was measured with a gamma camera. The half-life of 99mTc-DTPA was 94 +/- 16 min in normal lungs, and 10 +/- 1 min after detergent administration (p < 0.001). The half-life for 99mTc-sestamibi was 45 +/- 4 min and 39 +/- 4 min, respectively, (p < 0.05). There was no significant difference between the half-life of 99mTc-HIDA in normal lungs and in lungs with surfactant dysfunction. The half-life was 20 +/- 3 min and 17 +/- 2 min, respectively. The results indicate that the clearance rate limiting factors for the alveolocapillary transfer of water and lipid soluble substances are not the same. Surfactant dysfunction affects the transfer of water soluble substances (99mTc-DTPA) but not of substances with high lipid solubility (99mTc-HIDA).

  • 70.
    Norbäck, Dan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Lu, Chan
    Cent S Univ, Sch Energy Sci & Engn, Changsha, Hunan, Peoples R China.
    Wang, Juan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Zhang, Yinping
    Tsinghua Univ, Sch Architecture, Beijing, Peoples R China.
    Li, Baizhan
    Chongqing Univ, Key Lab Three Gorges Reservoir Regions Ecoenviron, Chongqing, Peoples R China.
    Zhao, Zhuohui
    Fudan Univ, Dept Environm Hlth, Shanghai, Peoples R China.
    Huang, Chen
    Univ Shanghai Sci & Technol, Sch Environm & Architecture, Dept Bldg Environm & Energy Engn, Shanghai, Peoples R China.
    Zhang, Xin
    Shanxi Univ, Res Ctr Environm Sci & Engn, Taiyuan, Shanxi, Peoples R China.
    Qian, Hua
    Southeast Univ, Sch Energy & Environm, Nanjing, Jiangsu, Peoples R China.
    Sun, Yuexia
    Tianjin Univ, Sch Environm Sci & Engn, Tianjin, Peoples R China.
    Sundell, Jan
    Tsinghua Univ, Sch Architecture, Beijing, Peoples R China.
    Deng, Qihong
    Cent S Univ, XiangYa Sch Publ Hlth, Changsha, Hunan, Peoples R China.
    Doctor diagnosed asthma and wheeze among Chinese pre-school children in relation to indoor and outdoor air pollution and urbanization2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 71.
    Nwaru, Bright
    et al.
    Univ Gothenburg, Gothenburg, Sweden.
    Ekström, Magnus
    Lund Univ, Lund, Sweden.
    Wiklund, Fredrik
    Statisticon AB, Uppsala, Sweden.
    Telg, Gunilla
    AstraZeneca, Sodertalje, Sweden.
    Nordahl, Helene
    AstraZeneca, Södertälje, Sweden.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Late Breaking Abstract - Oral corticosteroids exposure in a Swedish nationwide asthma population during 2006-20162018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 72. Olivieri, M.
    et al.
    Mirabelli, M. C.
    Plana, E.
    Radon, K.
    Antó, J. M.
    Bakke, P.
    Benke, G.
    D'Errico, A.
    Henneberger, P.
    Kromhout, H.
    Norbäck, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Torén, K.
    van Sprundel, M.
    Villani, S.
    Wieslander, Gunilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Zock, J-P
    Kogevinas, M.
    Healthy hire effect, job selection and inhalation exposure among young adults with asthma2010In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 36, no 3, p. 517-523Article in journal (Refereed)
    Abstract [en]

    The aim of the present study was to assess whether asthma onset prior to entering the workforce influences whether a person holds a subsequent job with asthma-related inhalation exposures. The data of 19,784 adults from the European Community Respiratory Health Survey were analysed. For each respondent, a current or previously held job was linked to a job exposure matrix assigning high, low or no exposure to dust, gases or fumes. Jobs were also categorised according to the risk of exposures related to occupational asthma. Associations between asthma and subsequent occupational exposures were assessed using logistic regression models, with a random intercept for study centre and fixed adjustment for age, sex, type of study sample and smoking status. Of the respondents, 8% (n=1,619) reported asthma with onset before completion of full-time education. This population was at decreased risk of having a job with high (odds ratio 0.79; 95% confidence interval 0.68-0.92) or low (0.91; 0.80-1.03) exposure to dust, gases or fumes. The associations were consistent across exposure types (dusts, gases or fumes) and for jobs with a high risk of occupational asthma. Adults with asthma onset prior to entering the workforce may be less likely to hold jobs involving inhalation exposures.

  • 73.
    Pekkanen, Juha
    et al.
    Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.;Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland..
    Valkonen, Maria
    Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.;Univ Eastern Finland, Dept Environm & Biol Sci, Kuopio, Finland..
    Täubel, Martin
    Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland..
    Tischer, Christina
    ISGlobal, Barcelona Inst Global Hlth, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBER Epidemiol Salud Publ, CIBERESP, Madrid, Spain..
    Leppänen, Hanna
    Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland..
    Kärkkäinen, Päivi M.
    Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland..
    Rintala, Helena
    Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland..
    Zock, Jan-Paul
    ISGlobal, Barcelona Inst Global Hlth, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBER Epidemiol Salud Publ, CIBERESP, Madrid, Spain..
    Casas, Lidia
    Katholieke Univ Leuven, Ctr Environm & Hlth, Dept Publ Hlth & Primary Care, Leuven, Belgium..
    Probst-Hensch, Nicole
    Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Dept Publ Hlth, Basel, Switzerland..
    Forsberg, Bertil
    Umea Univ, Dept Publ Hlth & Clin Med Occupat & Environm Me, Umea, Sweden..
    Holm, Mathias
    Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden..
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Pin, Isabelle
    Univ Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France..
    Gislason, Thorarinn
    Landspitali Univ Hosp, Dept Resp Med & Sleep, E7, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
    Jarvis, Debbie
    Natl Heart & Lung Inst, Imperial Coll, Populat Hlth & Occupat Dis, London, England.;Imperial Coll, MRC PHE Ctr Environm & Hlth, London, England..
    Heinrich, Joachim
    Ludwig Maximillians Univ Munich, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol 1, Helmholtz Zentrum Munchen, Neuherberg, Germany..
    Hyvärinen, Anne
    Univ Helsinki, Dept Publ Hlth, Helsinki, Finland..
    Indoor bacteria and asthma in adults: a multicentre case-control study within ECRHS II2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 51, no 2, article id 1701241Article in journal (Refereed)
    Abstract [en]

    Both protective and adverse effects of indoor microbial exposure on asthma have been reported, but mostly in children. To date, no study in adults has used non-targeted methods for detection of indoor bacteria followed by quantitative confirmation. A cross-sectional study of 198 asthmatic and 199 controls was conducted within the European Community Respiratory Health Survey (ECRHS) II. DNA was extracted from mattress dust for bacterial analysis using denaturing gradient gel electrophoresis (DGGE). Selected bands were sequenced and associations with asthma confirmed with four quantitative PCR (qPCR) assays. 15 out of 37 bands detected with DGGE, which had at least a suggestive association (p<0.25) with asthma, were sequenced. Of the four targeted qPCRs, Clostridium cluster XI confirmed the protective association with asthma. The association was dose dependent (aOR 0.43 (95% CI 0.22-0.84) for the fourth versus first quartile, p for trend 0.009) and independent of other microbial markers. Few significant associations were observed for the three other qPCRs used. In this large international study, the level of Clostridium cluster XI was independently associated with a lower risk of prevalent asthma. Results suggest the importance of environmental bacteria also in adult asthma, but need to be confirmed in future studies.

  • 74.
    Peralta, Gabriela P.
    et al.
    ISGlobal, Barcelona, Spain; UPF, Barcelona, Spain; CIBERESP, Barcelona, Spain.
    Fuertes, Elaine
    ISGlobal, Barcelona, Spain; UPF, Barcelona, Spain; CIBERESP, Barcelona, Spain.
    Carsin, Anne-Elie
    ISGlobal, Barcelona, Spain; UPF, Barcelona, Spain;CIBERESP, Barcelona, Spain.
    Probst-Hensch, Nicole
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland; Univ Basel, Basel, Switzerland.
    Marcon, Alessandro
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Nowak, Dennis
    LMU, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany; CPC M, Munich, Germany.
    Amaral, Andre F. S.
    Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.
    Johannessen, Ane
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Dharmage, Shyamali
    Univ Melbourne, Allergy & Lung Hlth Unit, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia.
    Gislason, Thorarinn
    Landspitali Univ Hosp Reykjavik, Dept Resp Med & Sleep, Reykjavik, Iceland.
    Garcia-Larsen, Vanessa
    Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Program Human Nutr, Baltimore, MD USA.
    Abramson, Michael J.
    Monash Univ, Dept Epidemiol & Prevent Med, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
    Sigsgaard, Torben
    Aarhus Univ, Dept Publ Hlth, Sect Environm Occupat & Hlth, Danish Ramazzini Ctr, Aarhus, Denmark.
    Anto, Josep M.
    ISGlobal, Barcelona, Spain; UPF, Barcelona, Spain; CIBERESP, Barcelona, Spain.
    Weyler, Joost
    Univ Antwerp, Dept Epidemiol & Social Med, Antwerp, Belgium.
    Bono, Roberto
    Univ Turin, Dept Publ Hlth & Pediat, Turin, Italy.
    Holm, Mathias
    Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.
    Burney, Peter
    Imperial Coll London, Natl Heart & Lung Inst, Resp Epidemiol & Publ Hlth Grp, London, England.
    Heinrich, Joachim
    LMU, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany; Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, Munich, Germany.
    Forsberg, Bertil
    Umeå Univ, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, Umeå, Sweden.
    Raherison-Semjen, Chantal
    Bordeaux Univ, Inst Publ Hlth & Epidemiol, INSERM U897, Bordeaux, France.
    Siroux, Valerie
    CNRS UMR 5309, Inserm U1209, Ctr Rech UGA, Inst Adv Biosci, Equipe Epidemiol Environm, Site Sante, Allee Alpes, La Tronche, France.
    Leynaert, Benedicte
    Inserm UMR 1152, Paris, France.
    Accordini, Simone
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Martinez-Moratalla, Jesus
    Univ Castilla La Mancha, Fac Med Albacete, Albacete, Spain.
    Sanchez-Ramos, Jose-Luis
    Univ Huelva, Dept Nursing, Huelva, Spain.
    Jarvis, Deborah L.
    Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England; Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England.
    Garcia-Aymerich, Judith
    ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain; CIBERESP, Barcelona, Spain.
    Body mass index trajectories during adult life and lung function decline2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 75.
    Perotin, Jeanne-Marie
    et al.
    Univ Southampton, NIHR Southampton Biomed Res Ctr, Clin & Expt Sci, Fac Med, Southampton, Hants, England.
    Schofield, James P. R.
    Univ Southampton, NIHR Southampton Biomed Res Ctr, Clin & Expt Sci, Fac Med, Southampton, Hants, England;Univ Southampton, Ctr Prote Res, Biol Sci, Southampton, Hants, England.
    Wilson, Susan J.
    Univ Southampton, Histochem Res Unit, Fac Med, Southampton, Hants, England.
    Ward, Jonathan
    Univ Southampton, Histochem Res Unit, Fac Med, Southampton, Hants, England.
    Brandsma, Joost
    Univ Southampton, NIHR Southampton Biomed Res Ctr, Clin & Expt Sci, Fac Med, Southampton, Hants, England.
    Strazzeri, Fabio
    Univ Southampton, Math Sci, Southampton, Hants, England.
    Bansal, Aruna
    Acclarogen Ltd, Cambridge, England.
    Yang, Xian
    Imperial Coll London, Data Sci Inst, London, England.
    Rowe, Anthony
    Janssen Res & Dev, High Wycombe, Bucks, England.
    Corfield, Julie
    Areteva Ltd, Nottingham, England.
    Lutter, Rene
    Univ Amsterdam, Amsterdam Infect & Immun Inst, Dept Expt Immunol, Amsterdam UMC, Amsterdam, Netherlands;Univ Amsterdam, Dept Resp Med, Amsterdam UMC, Amsterdam, Netherlands.
    Shaw, Dominick E.
    Univ Nottingham, NIHR Biomed Resp Res Ctr, Nottingham, England.
    Bakke, Per S.
    Univ Bergen, Inst Med, Bergen, Norway.
    Caruso, Massimo
    Univ Catania, Dept Clin & Expt Med, Hosp Univ, Catania, Italy;Univ Catania, Dept Biomed & Biotechnol Sci Biometec, Catania, Italy.
    Dahlen, Barbro
    Karolinska Inst, Karolinska Univ Hosp, Dept Resp Dis & Allergy, Stockholm, Sweden.
    Fowler, Stephen J.
    Univ Manchester, Resp & Allergy Res Grp, Manchester, Lancs, England.
    Horvath, Ildiko
    Semmelweis Univ, Dept Pulmonol, Budapest, Hungary.
    Howarth, Peter
    Univ Southampton, NIHR Southampton Biomed Res Ctr, Clin & Expt Sci, Fac Med, Southampton, Hants, England.
    Krug, Norbert
    Fraunhofer Inst Toxicol & Expt Med Hannover, Hannover, Germany.
    Montuschi, Paolo
    Univ Cattolica Sacro Cuore, Fdn Policlin Univ, Agostino Gemelli IRCCS, Fac Med, Rome, Italy.
    Sanak, Marek
    Jagiellonian Univ, Coll Med, Lab Mol Biol & Clin Genet, Krakow, Poland.
    Sandstrom, Thomas
    Umea Univ, Dept Publ Hlth & Clin Med, Dept Med, Resp Med Unit, Umea, Sweden.
    Sun, Kai
    Janssen Res & Dev, High Wycombe, Bucks, England.
    Pandis, Ioannis
    Janssen Res & Dev, High Wycombe, Bucks, England.
    Auffray, Charles
    Univ Lyon, European Inst Syst Biol & Med, CNRS, ENS,UCBL,INSERM, Lyon, France.
    De Meulder, Bertrand
    Univ Lyon, European Inst Syst Biol & Med, CNRS, ENS,UCBL,INSERM, Lyon, France.
    Lefaudeux, Diane
    Univ Lyon, European Inst Syst Biol & Med, CNRS, ENS,UCBL,INSERM, Lyon, France.
    Riley, John H.
    GSK, Resp Therapeut Unit, Uxbridge, Middx, England.
    Sousa, Ana R.
    GSK, Resp Therapeut Unit, Uxbridge, Middx, England.
    Dahlen, Sven-Erik
    Karolinska Inst, Inst Environm Med, Ctr Allergy Res, Stockholm, Sweden.
    Adcock, Ian M.
    Imperial Coll London, Natl Heart & Lung Inst, Airways Dis Sect, Cell & Mol Biol Grp, London, England.
    Chung, Kian Fan
    Imperial Coll London, Natl Heart & Lung Inst, Airways Dis Sect, Cell & Mol Biol Grp, London, England.
    Sterk, Peter J.
    Univ Nottingham, NIHR Biomed Resp Res Ctr, Nottingham, England.
    Skipp, Paul J.
    Univ Southampton, Ctr Prote Res, Biol Sci, Southampton, Hants, England.
    Collins, Jane E.
    Univ Southampton, NIHR Southampton Biomed Res Ctr, Clin & Expt Sci, Fac Med, Southampton, Hants, England.
    Davies, Donna E.
    Univ Southampton, NIHR Southampton Biomed Res Ctr, Clin & Expt Sci, Fac Med, Southampton, Hants, England.
    Djukanovic, Ratko
    Univ Southampton, NIHR Southampton Biomed Res Ctr, Clin & Expt Sci, Fac Med, Southampton, Hants, England.
    Adcock, I. M.
    Imperial Coll, Natl Heart & Lung Inst, London, England.
    Ahmed, H.
    UCBL, ENS, CNRS, European Inst Syst Biol & Med,INSERM, Lyon, France.
    Auffray, C.
    UCBL, ENS, CNRS, European Inst Syst Biol & Med,INSERM, Lyon, France.
    Bakke, P.
    Univ Bergen, Dept Clin Sci, Bergen, Norway.
    Banssal, A. T.
    Acclarogen Ltd, St Johns Innovat Ctr, Cambridge, England.
    Baribaud, F.
    Janssen R&D, San Diego, CA USA.
    Bates, S.
    GSK, Resp Therapeut Unit, London, England.
    Bel, E. H.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Bigler, J.
    Amgen Inc, Thousand Oaks, CA 91320 USA.
    Bisgaard, H.
    Univ Copenhagen, COPSAC, Copenhagen Prospect Studies Asthma Childhood, Herlev & Gentofte Hosp, Copenhagen, Denmark.
    Boedigheimer, M. J.
    Amgen Inc, Thousand Oaks, CA 91320 USA.
    Bonnelykke, K.
    Univ Copenhagen, COPSAC, Copenhagen Prospect Studies Asthma Childhood, Herlev & Gentofte Hosp, Copenhagen, Denmark.
    Brandsma, J.
    Univ Southampton, Southampton, Hants, England.
    Brinkman, P.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Bucchioni, E.
    Chiesi Pharmaceut SPA, Parma, Italy.
    Burg, D.
    Univ Southampton, Inst Life Sci, Ctr Prote Res, Southampton, Hants, England.
    Bush, A.
    Imperial Coll, Natl Heart & Lung Inst, London, England;Royal Brompton & Harefield NHS Trust, London, England.
    Caruso, M.
    Univ Catania, Dept Clin & Expt Med, Catania, Italy.
    Chaiboonchoe, A.
    UCBL, ENS, CNRS, European Inst Syst Biol & Med,INSERM, Lyon, France.
    Chanez, P.
    Aix Marseille Univ, Assistance Publ Hop Marseille, Clin Bronches Allergies & Sommeil, Marseille, France.
    Chung, K. F.
    Imperial Coll, Natl Heart & Lung Inst, London, England.
    Compton, C. H.
    GSK, Resp Therapeut Unit, London, England.
    Corfield, J.
    Areteva R&D, Nottingham, England.
    D'Amico, A.
    Univ Roma Tor Vergata, Rome, Italy.
    Dahlen, S. E.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    De Meulder, B.
    UCBL, ENS, CNRS, European Inst Syst Biol & Med,INSERM, Lyon, France.
    Djukanovic, R.
    NIHR Southampton Resp Biomed Res Unit & Clin & Ex, Southampton, Hants, England.
    Erpenbeck, V. J.
    Novartis Inst Biomed Res, Translat Med, Resp Profiling, Basel, Switzerland.
    Erzen, D.
    Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
    Fichtner, K.
    Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
    Fitch, N.
    BioSci Consulting, Maasmechelen, Belgium.
    Fleming, L. J.
    Imperial Coll, Natl Heart & Lung Inst, London, England;Royal Brompton & Harefield NHS Trust, London, England.
    Formaggio, E.
    CROMSOURCE, Verona, Italy.
    Fowler, S. J.
    Univ Manchester, Inst Inflammat & Repair, Ctr Resp Med & Allergy, Manchester, Lancs, England;Univ Hosp South Manchester, Manchester Acad Hlth Ctr, Manchester, Lancs, England.
    Frey, U.
    Univ Childrens Hosp, Basel, Switzerland.
    Gahlemann, M.
    Boehringer Ingelheim Schweiz GmbH, Basel, Switzerland.
    Geiser, T.
    Univ Hosp Bern, Dept Resp Med, Bern, Switzerland.
    Guo, Y.
    Imperial Coll, Data Sci Inst, London, England.
    Hashimoto, S.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Haughney, J.
    Int Primary Care Resp Grp, Aberdeen, Scotland.
    Hedlin, G.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
    Hekking, P. W.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Higenbottam, T.
    Allergy Therapeut, Worthing, W Sussex, England.
    Hohlfeld, J. M.
    Fraunhofer Inst Toxicol & Expt Med, Hannover, Germany.
    Holweg, C.
    Genentech Inc, Resp & Allergy Dis, San Francisco, CA USA.
    Horvath, I.
    Semmelweis Univ, Budapest, Hungary.
    Howarth, P.
    NIHR Southampton Resp Biomed Res Unit, Clin & Expt Sci & Human Dev & Hlth, Southampton, Hants, England.
    James, A. J.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Knowles, R.
    Arachos Pharma, Stevenge, England.
    Knox, A. J.
    Univ Nottingham, Resp Res Unit, Nottingham, England.
    Krug, N.
    Fraunhofer Inst Toxicol & Expt Med, Hannover, Germany.
    Lefaudeux, D.
    UCBL, INSERM, ENS, European Inst Syst Biol & Med,CNRS, Lyon, France.
    Loza, M. J.
    Janssen R&D, San Diego, CA USA;Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Lutter, R.
    Manta, A.
    Roche Diagnost GmbH, Mannheim, Germany;Roche Diagnost GmbH, Mannheim, Germany.
    Masefield, S.
    European Lung Fdn, Sheffield, S Yorkshire, England.
    Matthews, J. G.
    Genentech Inc, Resp & Allergy Dis, San Francisco, CA USA.
    Mazein, A.
    UCBL, INSERM, ENS, European Inst Syst Biol & Med,CNRS, Lyon, France.
    Meiser, A.
    Imperial Coll, Data Sci Inst, London, England.
    Middelveld, R. J. M.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Miralpeix, M.
    Almirall, Barcelona, Spain.
    Montuschi, P.
    Univ Cattolica Sacro Cuore, Milan, Italy;Univ Cattolica Sacro Cuore, Milan, Italy.
    Mores, N.
    Univ Cattolica Sacro Cuore, Milan, Italy.
    Murray, C. S.
    Univ Manchester, Inst Inflammat & Repair, Ctr Resp Med & Allergy, Manchester, Lancs, England;Univ Hosp South Manchester, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
    Musial, J.
    Jagiellonian Univ, Dept Med, Med Coll, Krakow, Poland.
    Myles, D.
    GSK, Resp Therapeut Unit, London, England.
    Pahus, L.
    Aix Marseille Univ, Assistance Publ Hop Marseille, Clin Bronches Allergies & Sommeil, Espace Eth Mediterraneen, Marseille, France.
    Pandis, I.
    Imperial Coll, Data Sci Inst, London, England.
    Pavlidis, S.
    Imperial Coll, Natl Heart & Lung Inst, London, England.
    Powell, P.
    European Lung Fdn, Sheffield, S Yorkshire, England.
    Pratico, G.
    CROMSOURCE, Verona, Italy.
    Puig Valls, M.
    CROMSOURCE, Barcelona, Spain.
    Rao, N.
    Janssen R&D, San Diego, CA USA.
    Riley, J.
    GSK, Resp Therapeut Unit, London, England.
    Roberts, A.
    Asthma UK, London, England.
    Roberts, G.
    NIHR Southampton Resp Biomed Res Unit, Clin & Expt Sci & Human Dev & Hlth, Southampton, Hants, England.
    Rowe, A.
    Janssen R&D, High Wycombe, Bucks, England.
    Sandstrom, T.
    Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
    Seibold, W.
    Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
    Selby, A.
    NIHR Southampton Resp Biomed Res Unit, Clin & Expt Sci & Human Dev & Hlth, Southampton, Hants, England.
    Shaw, D. E.
    Univ Nottingham, Resp Res Unit, Nottingham, England.
    Sigmund, R.
    Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
    Singer, F.
    Univ Childrens Hosp, Zurich, Switzerland.
    Skipp, P. J.
    Univ Southampton, Inst Life Sci, Ctr Prote Res, Southampton, Hants, England.
    Sousa, A. R.
    GSK, Resp Therapeut Unit, London, England.
    Sterk, P. J.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Sun, K.
    Imperial Coll, Data Sci Inst, London, England.
    Thornton, B.
    MSD, Louisville, KY USA.
    van Aalderen, W. M.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    van Geest, M.
    AstraZeneca, Molndal, Sweden.
    Vestbo, J.
    Univ Manchester, Inst Inflammat & Repair, Ctr Resp Med & Allergy, Manchester, Lancs, England;Univ Hosp South Manchester, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
    Vissing, N. H.
    Univ Copenhagen, Herlev & Gentofte Hosp, COPSAC, Copenhagen Prospect Studies Asthma Childhood, Copenhagen, Denmark.
    Wagener, A. H.
    Acad Med Ctr Amsterdam, Amsterdam, Netherlands.
    Wagers, S. S.
    BioSci Consulting, Maasmechelen, Belgium.
    Weiszhart, Z.
    Semmelweis Univ, Budapest, Hungary.
    Wheelock, C. E.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Wilson, S. J.
    Univ Southampton, Histochem Res Unit, Fac Med, Southampton, Hants, England.
    Aliprantis, Antonios
    Merck Res Labs, Boston, MA USA.
    Allen, David
    Pennine Acute Hosp NHS Trust, North West Severe Asthma Network, Oldham, England.
    Alving, Kjell
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Badorrek, P.
    Fraunhofer ITEM, Hannover, Germany.
    Balgoma, David
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Ballereau, S.
    Univ Lyon, European Inst Syst Biol & Med, Lyon, France.
    Barber, Clair
    NIHR Southampton Resp Biomed Res Unit, Southampton, Hants, England.
    Batuwitage, Manohara Kanangana
    Imperial Coll, Data Sci Inst, London, England.
    Bautmans, An
    MSD, Brussels, Belgium.
    Bedding, A.
    Roche Diagnost GmbH, Mannheim, Germany.
    Behndig, A. F.
    Umea Univ, Umea, Sweden.
    Beleta, Jorge
    Almirall SA, Barcelona, Spain.
    Berglind, A.
    MSD, Brussels, Belgium.
    Berton, A.
    AstraZeneca, Molndal, Sweden.
    Bochenek, G.
    Jagiellonian Univ, Dept Internal Med 2, Med Coll, Krakow, Poland.
    Braun, A.
    Fraunhofer Inst Toxicol & Expt Med, Hannover, Germany.
    Campagna, D.
    Univ Catania, Dept Clin & Expt Med, Catania, Italy.
    Carayannopoulos, L.
    MSD, Louisville, KY USA.
    Casaulta, C.
    Univ Childrens Hosp Bern, Bern, Switzerland.
    Chaleckis, Romanas
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Dahlen, B.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden;Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden.
    Davison, T.
    Janssen R&D, San Diego, CA USA.
    De Alba, J.
    Almirall SA, Barcelona, Spain.
    De Lepeleire, I.
    MSD, Brussels, Belgium.
    Dekker, T.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Delin, I.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Dennison, P.
    Univ Southampton, NIHR Southampton Resp Biomed Res Unit, Clin & Expt Sci, NIHR Wellcome Trust Clin Res Facil,Fac Med, Southampton, Hants, England.
    Dijkhuis, A.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Dodson, P.
    AstraZeneca, Molndal, Sweden.
    Dyson, K.
    CROMSOURCE, Stirling, Scotland.
    Edwards, J.
    Asthma UK, London, England.
    El Hadjam, L.
    Univ Lyon, European Inst Syst Biol & Med, Lyon, France.
    Emma, R.
    Univ Catania, Dept Clin & Expt Med, Catania, Italy.
    Ericsson, M.
    Karolinska Univ Hosp, Stockholm, Sweden.
    Faulenbach, C.
    Fraunhofer ITEM, Hannover, Germany.
    Flood, Breda
    European Federat Allergy & Airways Dis Patients A, Brussels, Belgium.
    Galffy, G.
    Semmelweis Univ, Budapest, Hungary.
    Gallart, H.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Garissi, D.
    CROMSOURCE, Global Head Clin Res Div, Rome, Italy.
    Gent, J.
    Royal Brompton & Harefield NHS Fdn Trust, London, England.
    de Verdier, M. Gerhardsson
    AstraZeneca, Molndal, Sweden.
    Gibeon, D.
    Imperial Coll, Natl Heart & Lung Inst, London, England.
    Gomez, Cristina
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Gove, K.
    NIHR Southampton Resp Biomed Res Unit, Southampton, Hants, England.
    Guillmant-Farry, E.
    Royal Brompton Hosp, London, England.
    Henriksson, E.
    Karolinska Univ Hosp, Stockholm, Sweden;Karolinska Inst, Stockholm, Sweden.
    Hewitt, L.
    NIHR Southampton Resp Biomed Res Unit, Southampton, Hants, England.
    Hoda, U.
    Imperial Coll, London, England.
    Hu, Richard
    Amgen Inc, Thousand Oaks, CA 91320 USA.
    Hu, S.
    Imperial Coll, Natl Heart & Lung Inst, London, England.
    Hu, X.
    Amgen Inc, Thousand Oaks, CA 91320 USA.
    Jeyasingham, E.
    GSK, UK Clin Operat, Stockley Pk, England.
    Johnson, K.
    Univ Hosp South Manchester NHS Fdn Trust, Ctr Resp Med & Allergy Inst Inflammat & Repair, Manchester, Lancs, England.
    Jullian, N.
    Univ Lyon, European Inst Syst Biol & Med, Lyon, France.
    Kamphuis, J.
    Longfonds, Amersfoort, Netherlands.
    Kennington, E. J.
    Asthma UK, London, England.
    Kerry, D.
    CromSource, Stirling, Scotland.
    Kerry, G.
    NHS Fdn Trust, Univ Hosp South Manchester, Inst Inflammat & Repair, Ctr Resp Med & Allergy, Manchester, Lancs, England.
    Klueglich, M.
    Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
    Knobel, H.
    Philips Res Labs, Eindhoven, Netherlands.
    Kolmert, Johan
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Konradsen, J. R.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
    Kots, M.
    Chiesi Pharmaceut SPA, Parma, Italy.
    Kretsos, Kosmas
    UCB, Slough, Berks, England.
    Krueger, L.
    Univ Childrens Hosp Bern, Bern, Switzerland.
    Kuo, S.
    Imperial Coll, Natl Heart & Lung Inst, London, England.
    Kupczyk, M.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Lambrecht, B.
    Univ Ghent, Ghent, Belgium.
    Lantz, A-S
    Larminie, Christopher
    GSK, London, England.
    Larsson, L. X.
    AstraZeneca, Molndal, Sweden.
    Latzin, P.
    Univ Childrens Hosp Bern, Bern, Switzerland.
    Lazarinis, N.
    Karolinska Univ Hosp, Stockholm, Sweden;Karolinska Inst, Stockholm, Sweden.
    Lemonnier, N.
    UCBL, INSERM, ENS, European Inst Syst Biol & Med,CNRS, Lyon, France.
    Lone-Latif, S.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Lowe, L. A.
    NHS Fdn Trust, Univ Hosp South Manchester, Inst Inflammat & Repair, Ctr Resp Med & Allergy, Manchester, Lancs, England.
    Marouzet, L.
    NIHR Southampton Resp Biomed Res Unit, Southampton, Hants, England.
    Martin, J.
    NIHR Southampton Resp Biomed Res Unit, Southampton, Hants, England.
    Mathon, C.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    McEvoy, L.
    Univ Hosp, Dept Pulm Med, Bern, Switzerland.
    Meah, S.
    Imperial Coll, Natl Heart & Lung Inst, London, England.
    Menzies-Gow, A.
    Royal Brompton & Harefield NHS Fdn Trust, London, England.
    Metcalf, L.
    Asthma UK, London, England.
    Mikus, M.
    Sci Life Lab, Stockholm, Sweden;Royal Inst Technol, Stockholm, Sweden.
    Monk, P.
    Synairgen Res Ltd, Southampton, Hants, England.
    Naz, S.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Nething, K.
    Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
    Nicholas, B.
    Univ Southampton, Southampton, Hants, England.
    Nihlen, U.
    AstraZeneca, Molndal, Sweden.
    Nilsson, Peter
    Sci Life Lab, Stockholm, Sweden;Royal Inst Technol, Stockholm, Sweden.
    Niven, R.
    Univ Hosp South Manchester, North West Severe Asthma Network, Manchester, Lancs, England.
    Nordlund, B.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
    Nsubuga, S.
    Royal Brompton Hosp, London, England.
    Ostling, J.
    AstraZeneca, Molndal, Sweden.
    Pacino, A.
    Lega Italiano Anti Fumo, Catania, Italy.
    Palkonen, S.
    European Federat Allergy & Airways Dis Patients A, Brussels, Belgium.
    Pellet, J.
    UCBL, CNRS, ENS, European Inst Syst Biol & Med,INSERM, Lyon, France.
    Pennazza, G.
    Univ Roma Tor Vergata, Rome, Italy.
    Petren, A.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Pink, S.
    NIHR Southampton Resp Biomed Res Unit, Southampton, Hants, England.
    Pison, C.
    UCBL, INSERM, CNRS, European Inst Syst Biol & Med,ENS, Lyon, France.
    Postle, A.
    Univ Southampton, Southampton, Hants, England.
    Rahman-Amin, M.
    Asthma UK, London, England.
    Ravanetti, L.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Ray, E.
    NIHR Southampton Resp Biomed Res Unit, Southampton, Hants, England.
    Reinke, S.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Reynolds, L.
    Asthma UK, London, England.
    Riemann, K.
    Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
    Robberechts, Martine
    MSD, Brussels, Belgium.
    Rocha, J. P.
    Royal Brompton & Harefield NHS Fdn Trust, London, England.
    Rossios, C.
    Imperial Coll, Natl Heart & Lung Inst, London, England.
    Russell, K.
    Imperial Coll, Natl Heart & Lung Inst, London, England.
    Rutgers, M.
    Longfonds, Amersfoort, Netherlands.
    Santini, G.
    Univ Cattolica Sacro Cuore, Milan, Italy.
    Santoninco, M.
    Univ Roma Tor Vergata, Rome, Italy.
    Saqi, M.
    UCBL, CNRS, INSERM, European Inst Syst Biol & Med,ENS, Lyon, France.
    Schoelch, C.
    Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
    Schofield, J. P. R.
    Univ Southampton, Inst Life Sci, Ctr Prote Res, Southampton, Hants, England.
    Scott, S.
    Countess Chester Hosp, North West Severe Asthma Network, Chester, Cheshire, England.
    Sehgal, N.
    Pennine Acute Hosp NHS Trust, North West Severe Asthma Network, Oldham, England.
    Sjodin, M.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
    Smids, B.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Smith, Caroline
    NIHR Southampton Resp Biomed Res Unit, Southampton, Hants, England.
    Smith, J.
    Asthma UK, London, England.
    Smith, K. M.
    Univ Nottingham, Nottingham, England.
    Soderman, P.
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
    Sogbessan, A.
    Royal Brompton & Harefield NHS Fdn Trust, London, England.
    Spycher, F.
    Univ Hosp, Dept Pulm Med, Bern, Switzerland.
    Staykova, D.
    Univ Southampton, Southampton, Hants, England.
    Stephan, S.
    NHS Fdn Trust, Univ Hosp South Manchester, Inst Inflammat & Repair, Ctr Resp Med & Allergy, Manchester, Lancs, England.
    Stokholm, J.
    Univ Copenhagen, Copenhagen, Denmark;Danish Pediat Asthma Ctr, Copenhagen, Denmark.
    Strandberg, K.
    Karolinska Univ Hosp, Stockholm, Sweden;Karolinska Inst, Stockholm, Sweden.
    Sunther, M.
    NHS Fdn Trust, Univ Hosp South Manchester, Inst Inflammat & Repair, Ctr Resp Med & Allergy, Manchester, Lancs, England.
    Szentkereszty, M.
    Semmelweis Univ, Budapest, Hungary.
    Tamasi, L.
    Semmelweis Univ, Budapest, Hungary.
    Tariq, K.
    Univ Southampton, NIHR Southampton Resp Biomed Res Unit, Clin & Expt Sci, NIHR Wellcome Trust Clin Res Facil,Fac Med, Southampton, Hants, England.
    Thorngren, J-O
    Thorsen, Jonathan
    Univ Copenhagen, Copenhagen Prospect Studies Asthma Childhood, Herlev & Gentofte Hosp, COPSAC, Copenhagen, Denmark.
    Valente, S.
    Univ Cattolica Sacro Cuore, Milan, Italy.
    van de Pol, Marianne
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    van Drunen, C. M.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Van Eyll, J.
    UCB, Slough, Berks, England.
    Versnel, J.
    Asthma UK, London, England.
    Vink, A.
    Philips Res Labs, Eindhoven, Netherlands.
    von Garnier, C.
    Univ Hosp Bern, Bern, Switzerland.
    Vyas, A.
    Lancashire Teaching Hosp NHS Trust, North West Severe Asthma Network, Preston, Lancs, England.
    Wald, F.
    Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
    Walker, S.
    Asthma UK, London, England.
    Ward, J.
    Univ Southampton, Histochem Res Unit, Fac Med, Southampton, Hants, England.
    Wetzel, K.
    Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
    Wiegman, C.
    Imperial Coll, Natl Heart & Lung Inst, London, England.
    Williams, S.
    Int Primary Care Resp Grp, Aberdeen, Scotland.
    Yang, X.
    Imperial Coll, Data Sci Inst, London, England.
    Yeyasingham, E.
    GSK, UK Clin Operat, Stockley Pk, England.
    Yu, W.
    Amgen Inc, Thousand Oaks, CA 91320 USA.
    Zetterquist, W.
    Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
    Zolkipli, Z.
    NIHR Southampton Resp Biomed Res Unit, Clin & Expt Sci & Human Dev & Hlth, Southampton, Hants, England.
    Zwinderman, A. H.
    Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
    Prins, J-B
    Visintin, L.
    Evans, H.
    Puhl, M.
    Buzermaniene, L.
    Hudson, V.
    Bond, L.
    de Boer, P.
    Widdershoven, G.
    Supple, D.
    Hamerlijnck, D.
    Negus, J.
    Sergison, L.
    Onstein, S.
    MacNee, W.
    Bernardini, R.
    Bont, Louis
    Wecksell, P-A
    Draper, Aleksandra
    BioSci Consulting, Maasmechelen, Belgium.
    Gozzard, Neil
    UCB, Slough, Berks, England.
    Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux2019In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 53, no 6, article id 1900453Article in journal (Other academic)
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    Pesce, Giancarlo
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    Univ Paris Diderot Paris 7, Dept Pathophysiol & Epidemiol Resp Dis, INSERM, UMR1152, Paris, France.
    Triebner, Kai
    Univ Bergen, Dept Clin Sci, Bergen, Norway.
    Van der Plaat, Diana
    Univ Paris Diderot Paris 7, Dept Pathophysiol & Epidemiol Resp Dis, INSERM, UMR1152, Paris, France.
    Courbon, Dominque
    Univ Paris Diderot Paris 7, Dept Pathophysiol & Epidemiol Resp Dis, INSERM, UMR1152, Paris, France.
    Marcon, Alessandro
    Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy.
    Accordini, Simone
    Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy.
    Anto, Josep
    ISGlobal, Barcelona, Spain.
    Dorado-Arenas, Sandra
    Galdakao Hosp, Pulmonol Dept, Bizkaia, Spain.
    Gullon, Jose
    Hosp Univ San Agustin, Serv Neumol, Aviles, Spain.
    Sanchez-Ramos, Jose
    Univ Huelva, Dept Nursing, Huelva, Spain.
    Pin, Isabelle
    Antenne Pediat CIC, Pneumol Pediat, Grenoble, France.
    Gislason, Thorarinn
    Landspitali, Dept Resp Med & Sleep, Reykjavik, Iceland.
    Torén, Kjell
    Univ Gothenburg, Sect Occupat & Environm Med, Gothenburg, Sweden.
    Forsberg, Bertil
    Umeå Univ, Div Occupat & Environm Med, Umeå, Sweden.
    Lindberg, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Zemp, Elizabeth
    Univ Basel, Dept Epidemiol & Publ Hlth, Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
    Jogi, Rain
    Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
    Dharmage, Shyamali
    Univ Melbourne, Allergy & Lung Hlth Unit, Sch Populat & Global Hlth, Melbourne, Vic, Australia.
    Probst, Nicole
    Univ Basel, Dept Epidemiol & Publ Hlth, Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
    Jarvis, Deborah
    Imperial Coll, Populat Hlth & Occupat Dis, Natl Heart & Lung Inst, London, England.
    Garcia-Aymerich, Judith
    ISGlobal, Barcelona, Spain.
    Gomez-Real, Francisco
    Univ Bergen, Dept Clin Sci, Bergen, Norway.
    Leynaert, Benedicte
    Univ Paris Diderot Paris 7, Dept Pathophysiol & Epidemiol Resp Dis, INSERM, UMR1152, Paris, France.
    Low dehydroepiandrosterone sulfate (DHEA-S) is associated with worse lung function in women.2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
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    Pisinger, Charlotta
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    Univ Copenhagen, Copenhagen, Denmark;Bispebjerg Frederiksberg Hosp, Copenhagen, Denmark.
    Dagli, Elif
    Marmara Univ, Istanbul, Turkey.
    Filippidis, Filippos T.
    Imperial Coll, Dept Primary Care & Publ Hlth, London, England.
    Hedman, Linnea
    Umea Univ, Dept Sustainable Hlth, OLIN Unit, Umea, Sweden.
    Jansson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Loukides, Stelios
    Univ Athens, Athens, Greece.
    Ravara, Sofia
    Univ Beira Interior, Hlth Sci Res Ctr, CSIC, Covilha, Portugal;Univ Nova Lisboa, Publ Hlth Res Ctr, NOVA Natl Sch Publ Hlth, Lisbon, Portugal.
    Saraiva, Isabel
    European Lung Fdn, Sheffield, S Yorkshire, England.
    Vestbo, Jörgen
    Univ Manchester, Manchester, Lancs, England;Manchester Univ NHS Fdn Trust, Manchester, Lancs, England.
    ERS and tobacco harm reduction2019In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54, no 6, article id 1902009Article in journal (Other academic)
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    Univ Barcelona, Hosp Univ Vall dHebron HUVH, Inst Recerca Vall dHebron VHIR,CIBERES, Hosp Clin Barcelona,Fdn Clin,Serv Pneumol,IDIBAPS, Barcelona, Spain..
    Goeminne, Pieter C.
    AZ Nikolaas, Dept Resp Med, St Niklaas, Belgium.;UZ Leuven, Dept Resp Med, Leuven, Belgium..
    McDonnell, Melissa J.
    Galway Univ Hosp, Dept Resp Med, Galway, Ireland.;Natl Univ Ireland, Lung Biol Grp, Galway, Ireland.;Newcastle Univ, Inst Cell & Mol Biol, Newcastle Upon Tyne, Tyne & Wear, England..
    Aliberti, Stefano
    Univ Milan, Dept Pathophysiol & Transplantat, Dept Internal Med, Resp Unit, Milan, Italy.;Fdn IRCCS Ca Granda Osped Maggiore Policlin Milan, Adult Cyst Fibrosis Ctr, Milan, Italy..
    Marshall, Sara E.
    Wellcome, Dept Clin Res Immunol & Physiol Sci, London, England..
    Loebinger, Michael R.
    Imperial Coll, Royal Brompton Hosp, Host Def Unit, London, England..
    Murris, Marlene
    CHU Toulouse, Hop Larrey, Serv Pneumol, Toulouse, France..
    Canton, Rafael
    Hosp Univ Ramon y Cajal, Microbiol Serv, Madrid, Spain.;Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain..
    Torres, Antoni
    Univ Barcelona, Hosp Clin Barcelona, Serv Pneumol, IDIBAPS,CIBERES Barcelona, Barcelona, Spain..
    Dimakou, Katerina
    Sotiria Chest Hosp, Pulm Dept 5, Athens, Greece..
    De Soyza, Anthony
    Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England.;Freeman Rd Hosp, Bronchiectasis Serv, Newcastle Upon Tyne, Tyne & Wear, England..
    Hill, Adam T.
    Royal Infirm, Dept Resp Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Edinburgh, Midlothian, Scotland..
    Haworth, Charles S.
    Papworth Hosp, Cambridge Ctr Lung Infect, Cambridge, England..
    Vendrell, Montserrat
    Dr Trueta Univ Hosp, Bronchiectasis Grp, Girona Biomed Res Inst IDIBGI, Girona, Spain..
    Ringshausen, Felix C.
    German Ctr Lung Res, Hannover Med Sch, Dept Resp Med, Hannover, Germany..
    Subotic, Dragan
    Univ Belgrade, Clin Thorac Surg, Clin Ctr Serbia, Belgrade, Serbia..
    Wilson, Robert
    Imperial Coll, Royal Brompton Hosp, Host Def Unit, London, England..
    Vilaro, Jordi
    Univ Ramon Llull, FCS Blanquerna Phys Act & Hlth Grp, Barcelona, Spain..
    Ställberg, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Welte, Tobias
    Dr Trueta Univ Hosp, Bronchiectasis Grp, Girona Biomed Res Inst IDIBGI, Girona, Spain..
    Rohde, Gernot
    Maastricht Univ, Med Ctr, Dept Resp Med, Maastricht, Netherlands..
    Blasi, Francesco
    Univ Milan, Dept Pathophysiol & Transplantat, Dept Internal Med, Resp Unit, Milan, Italy.;Fdn IRCCS Ca Granda Osped Maggiore Policlin Milan, Adult Cyst Fibrosis Ctr, Milan, Italy..
    Elborn, Stuart
    Imperial Coll, Royal Brompton Hosp, Host Def Unit, London, England.;Queens Univ Belfast, Belfast, Antrim, North Ireland..
    Almagro, Marta
    ELF, EMBARC Bronchiectasis Patient Advisory Grp, Sheffield, S Yorkshire, England..
    Timothy, Alan
    ELF, EMBARC Bronchiectasis Patient Advisory Grp, Sheffield, S Yorkshire, England..
    Ruddy, Thomas
    ELF, EMBARC Bronchiectasis Patient Advisory Grp, Sheffield, S Yorkshire, England..
    Tonia, Thomy
    Univ Bern, Inst Social & Prevent Med, Bern, Switzerland..
    Rigau, David
    Iberoamer Cochrane Ctr, Barcelona, Spain..
    Chalmers, James D.
    Univ Dundee, Coll Med, Ninewells Hosp & Med Sch, Dundee, Scotland..
    European Respiratory Society guidelines for the management of adult bronchiectasis2017In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 50, no 3, article id 1700629Article in journal (Refereed)
    Abstract [en]

    Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent exacerbations in many patients. There have been no previous international guidelines. The European Respiratory Society guidelines for the management of adult bronchiectasis describe the appropriate investigation and treatment strategies determined by a systematic review of the literature. A multidisciplinary group representing respiratory medicine, microbiology, physiotherapy, thoracic surgery, primary care, methodology and patients considered the most relevant clinical questions (for both clinicians and patients) related to management of bronchiectasis. Nine key clinical questions were generated and a systematic review was conducted to identify published systematic reviews, randomised clinical trials and observational studies that answered these questions. We used the GRADE approach to define the quality of the evidence and the level of recommendations. The resulting guideline addresses the investigation of underlying causes of bronchiectasis, treatment of exacerbations, pathogen eradication, long term antibiotic treatment, anti-inflammatories, mucoactive drugs, bronchodilators, surgical treatment and respiratory physiotherapy. These recommendations can be used to benchmark quality of care for people with bronchiectasis across Europe and to improve outcomes.

  • 79.
    Portas, Laura
    et al.
    Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy.
    Calciano, Lucia
    Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy.
    Corsico, Angelo Guido
    Univ Pavia, Div Resp Dis, IRCCS San Matteo Hosp Fdn, Pavia, Italy.
    Cazzoletti, Lucia
    Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy.
    Cerveri, Isa
    Univ Pavia, Div Resp Dis, IRCCS San Matteo Hosp Fdn, Pavia, Italy.
    Gerbase, Margaret W.
    Univ Hosp Geneva, Div Pulm Med, Geneva, Switzerland.
    Gislason, David
    Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland.
    Gronseth, Rune
    Haukeland Hosp, Dept Thorac Med, Bergen, Norway.
    Heinrich, Joachim
    Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Inner City Clin, Univ Hosp Munich, Munich, Germany.
    Jögi, Rain
    Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
    Johannessen, Ane
    Univ Bergen, Ctr Int Hlth, Bergen, Norway.
    Marcon, Alessandro
    Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy.
    Pin, Isabelle
    CHU Grenoble Alpes, Pediat, Grenoble, France.
    Wacker, Margarethe
    Helmholtz Zentrum, Inst Hlth Econ & Hlth Care Management, Munich, Germany.
    Jarvis, Deborah
    Natl Heart & Lung Inst, Fac Med, London, England.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Accordini, Simone
    Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy.
    Cost variations of asthma over 10 years in adults2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 80.
    Real, Francisco Gomez
    et al.
    Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynaecol, Bergen, Norway.
    Burgess, John A.
    Villani, Simona
    Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia;Univ Pavia, Dept Publ Hlth Expt & Forens Med, Unit Biostat & Clin Epidemiol, Pavia, Italy.
    Dratva, Julia
    Swiss Trop Inst, Inst Social & Prevent Med, Basel, Switzerland.
    Heinrich, Joachim
    Natl Res Ctr Environm & Hlth, Mol Epidemiol, Forschungszentrum Umwelt & Gesundheit, Neuherberg, Germany.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Jarvis, Debbie
    Imperial Coll, Dept Publ Hlth Sci, London, England.
    Koplin, Jennifer
    Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia.
    Leynaert, Benedicte
    Inserm, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Paris, France;Univ Paris Diderot Paris 7, Paris, France.
    Lodge, Caroline
    Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia.
    Laerum, Birger N.
    Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway.
    Matheson, Melanie C.
    Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia.
    Norbäck, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Omenaas, Ernst R.
    Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway;Haukeland Hosp, Ctr Clin Res, Bergen, Norway.
    Skulstad, Svein M.
    Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
    Sunyer, Jordi
    Ctr Recerca Epidemiol & Ambiental, Barcelona, Spain.
    Dharmage, Shyamali C.
    Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia.
    Svanes, Cecilie
    Haukeland Hosp, Dept Occupat Med, Bergen, Norway;Univ Bergen, Ctr Int Hlth, Bergen, Norway.
    Maternal age at delivery, lung function and asthma in offspring: a population-based survey2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 51, no 6, article id 1601611Article in journal (Refereed)
    Abstract [en]

    There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex. 10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years. In logistic and linear multilevel mixed models we adjusted for participants' characteristics (age, education, centre, number of older siblings) and maternal characteristics (smoking in pregnancy, education) while investigating for differential effects by sex. Maternal age was validated in a subsample using data from the Norwegian birth registry. Increasing maternal age was associated with increasing forced expiratory volume in 1 s (2.33 mL per year, 95% CI 0.34-4.32 mL per year), more consistent in females (p(trend) 0.025) than in males (ptrend 0.14). Asthma (OR 0.85, 95% CI 0.79-0.92) and respiratory symptoms (OR 0.87, 95% CI 0.82-0.92) decreased with increasing maternal age (per 5 years) in females, but not in males (p(interaction) 0.05 and 0.001, respectively). The results were consistent across centres and not explained by confounding factors. Maternal ageing was related to higher adult lung function and less asthma/symptoms in females. Biological characteristics in offspring related to maternal ageing are plausible and need further investigation.

  • 81. Rebordosa, C
    et al.
    Kogevinas, M
    Guerra, S
    Castro-Giner, F
    Jarvis, D
    Cazzoletti, L
    Pin, I
    Siroux, V
    Wjst, M
    Antò, J M
    de Marco, R
    Estivill, X
    Corsico, A G
    Nielsen, R
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
    ADRB2 Gly16Arg polymorphism, asthma control and lung function decline2011In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 38, no 5, p. 1029-1035Article in journal (Refereed)
    Abstract [en]

    Arg/Arg homozygotes for the Gly16Arg polymorphism in the β(2)-adrenoreceptor gene (ADRB2) have a reduced response to short-acting β(2)-agonists but no effect has been associated with long-acting β(2)-agonists (LABAs). We selected 604 subjects with current asthma from the European Community Respiratory Health Study to evaluate whether asthma control and lung function decline were associated with Gly16Arg polymorphism, and to test whether LABA or inhaled corticosteroid (ICS) use modified these effects. There was an increased risk of noncontrolled asthma (OR 1.33, 95% CI 1.01-1.75; p=0.046) for each Arg allele. Among nonusers of ICS, the odds ratio of noncontrolled asthma among Arg/Arg versus Gly/Gly subjects was 2.73 (95% CI 1.28-5.82; p=0.009). No increased risk of noncontrolled asthma associated with the Arg allele was observed among ICS and/or LABA users. For each Arg allele, a mean±se decrease in decline in forced expiratory volume in 1 s of 7.7±2.5 mL·yr(-1) was found (p-value for trend 0.003), irrespective of ICS or LABA use. Arg/Arg subjects had an increased risk of bronchial hyperresponsiveness (BHR) versus Gly/Gly subjects, with an odds ratio of 2.51 (95% CI 1.12-5.63; p=0.025) if they did not use ICS. The Arg allele was associated with poorer asthma control, a steeper lung function decline and BHR. Absence of genotypic effects on asthma control among ICS users may be due to reversed β(2)-adrenoreceptor desensitisation.

  • 82.
    Rydell, Andreas
    et al.
    Karolinska Inst, Stockholm, Sweden.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Lisspers, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Center for Clinical Research Dalarna.
    Ställberg, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD).
    Nowak, Christoph
    Karolinska Inst, Stockholm, Sweden.
    Carlsson, Axel
    Karolinska Inst, Stockholm, Sweden.
    Feldreich, Tobias
    Dalarna Univ, Falun, Sweden.
    Iggman, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Center for Clinical Research Dalarna.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    Ärnlöv, Johan
    Karolinska Inst, Stockholm, Sweden.
    Endothelial dysfunction is associated with impaired lung function in two independent community cohorts2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 83. Sabounchi-Schütt, F.
    et al.
    Åström, J.
    Hellman, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Eklund, A.
    Grunewald, J.
    Changes in bronchoalveolar lavage fluid proteins in sarcoidosis: a proteomics approach.2003In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 21, no 3, p. 414-20Article in journal (Refereed)
    Abstract [en]

    In sarcoidosis, an inflammatory lung disease, the protein profile of bronchoalveolar lavage fluid (BALF) is altered. To study the BALF protein pattern changes in sarcoidosis, samples from six patients and four healthy individuals were analysed by two-dimensional polyacrylamide gel electrophoresis. A comparison of the protein-spot patterns showed a significantly higher number of protein spots in the pH range 5.5-6.7 in patients compared to controls (472 versus 384). Furthermore, the number of protein spots in the patients were significantly decreased in the acidic pH range 4.5-5.5 (399 versus 518). Measurement of the optical density in the gels showed varying expression levels for several protein spots. Seventeen of the altered protein spots were identified, of which seven have previously not been reported for BALF. Many of these are nonplasma proteins involved in the inflammatory and oxidant-antioxidant processes. In conclusion, the bronchoalveolar lavage fluid protein content is altered in sarcoidosis patients, especially for proteins that are not derived from plasma. The described proteomics approach will in the future be used to asses overall changes in the protein content associated with sarcoidosis and may offer the possibility of identifying disease-specific proteins.

  • 84.
    Sandelowsky, Hanna
    et al.
    Karolinska Inst, Div Family Med & Primary Care, NVS, Stockholm, Sweden.
    Krakau, Ingvar
    Karolinska Inst, Div Clin Epidemiol, Dept Med, Stockholm, Sweden.
    Modin, Sonja
    Karolinska Inst, Div Family Med & Primary Care, NVS, Stockholm, Sweden.
    Ställberg, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Johansson, Sven-Erik
    Karolinska Inst, Div Family Med & Primary CareUniv, Dept Publ Hlth & Caring Sci, NVS,Family Med & Prevent Med, Stockholm, Sweden.
    Nager, Anna
    Karolinska Inst, Div Family Med & Primary CareUniv, Dept Publ Hlth & Caring Sci, NVS,Family Med & Prevent Med, Stockholm, Sweden.
    Effectiveness of 2x2-hour lectures and case methods in Swedish general practitioners' continuing medical education about COPD: a cluster randomized controlled trial2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 85. Shaheen, S.
    et al.
    Potts, J.
    Gnatiuc, L.
    Makowska, J.
    Kowalski, M. L.
    Joos, G.
    van Zele, T.
    van Durme, Y.
    De Rudder, I.
    Wöhrl, S.
    Godnic-Cvar, J.
    Skadhauge, L.
    Thomsen, G.
    Zuberbier, T.
    Bergmann, K. C.
    Heinzerling, L.
    Gjomarkaj, M.
    Bruno, A.
    Pace, E.
    Bonini, S.
    Fokkens, W.
    Weersink, E. J. M.
    Loureiro, C.
    Todo-Bom, A.
    Villanueva, C. M.
    Sanjuas, C.
    Zock, J-P.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
    Burney, P.
    The relation between paracetamol use and asthma: a GA2LEN European case-control study2008In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 32, no 5, p. 1231-1236Article in journal (Refereed)
    Abstract [en]

    Studies from the UK and USA suggest that frequent use of paracetamol (acetaminophen) may increase the risk of asthma, but data across Europe are lacking. As part of a multicentric case-control study organised by the Global Allergy and Asthma European Network (GA(2)LEN), it was examined whether or not frequent paracetamol use is associated with adult asthma across Europe. The network compared 521 cases with a diagnosis of asthma and reporting of asthma symptoms within the last 12 months with 507 controls with no diagnosis of asthma and no asthmatic symptoms within the last 12 months across 12 European centres. All cases and controls were selected from the same population, defined by age (20-45 yrs) and place of residence. In a random effects meta-analysis, weekly use of paracetamol, compared with less frequent use, was strongly positively associated with asthma after controlling for confounders. There was no evidence for heterogeneity across centres. No association was seen between use of other analgesics and asthma. These data add to the increasing and consistent epidemiological evidence implicating frequent paracetamol use in asthma in diverse populations.

  • 86. Sigsgaard, T
    et al.
    Clancy, L
    Forastiere, F
    Heederik, D
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
    Lundbäck, B
    Jiménez Ruiz, C
    Viegi, G
    20 years of research and advocacy for a healthy and tobacco-free environment2010In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 36, no 1, p. 1-3Article in journal (Refereed)
  • 87. Simoni, M.
    et al.
    Annesi-Maesano, I.
    Sigsgaard, T.
    Norbäck, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Wieslander, Gunilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Nystad, W.
    Canciani, M.
    Sestini, P.
    Viegi, G.
    School air quality related to dry cough, rhinitis and nasal patency in children2010In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 35, no 4, p. 742-749Article in journal (Refereed)
    Abstract [en]

    Controls for indoor air quality (IAQ) in schools are not usually performed throughout Europe. The aim of this study was to assess the effects of IAQ on respiratory health of schoolchildren living in Norway, Sweden, Denmark, France and Italy. In the cross-sectional European Union-funded HESE (Health Effects of School Environment) Study, particulate matter with a 50% cut-off aerodynamic diameter of 10 mu m (PM10) and CO2 levels in a day of normal activity (full classroom) were related to wheezing, dry cough at night and rhinitis in 654 children (10 yrs) and to acoustic rhinometry in 193 children. Schoolchildren exposed to PM10 >50 mu g.m(-3) and CO2 >1,000 ppm (standards for good IAQ) were 78% and 66%, respectively. All disorders were more prevalent in children from poorly ventilated classrooms. Schoolchildren exposed to CO2 levels >1,000 ppm showed a significantly higher risk for dry cough (OR 2.99, 95% CI 1.65-5.44) and rhinitis (OR 2.07, 95% CI 1.14-3.73). By two-level (child, classroom) hierarchical analyses, CO2 was significantly associated with dry cough (OR 1.06, 95% CI 1.00-1.13 per 100 ppm increment) and rhinitis (OR 1.06, 95% CI 1.00-1.11). Nasal patency was significantly lower in schoolchildren exposed to PM10 >50 mu g.m(-3) than in those exposed to lower levels. A poor IAQ is frequent in European classrooms; it is related to respiratory disturbances and affects nasal patency.

  • 88.
    Sköld, C. Magnus
    et al.
    Karolinska Inst, Stockholm, Sweden.
    Bartley, Karen
    Genentech Inc, San Francisco, CA USA.
    Levine, Aaron
    IQVIA, Solna, Sweden.
    Arnheim-Dahlstrom, Lisen
    IQVIA, Solna, Sweden.
    Kirchgaessler, Klaus-Uwe
    F Hoffmann La Roche Ltd, Basel, Switzerland.
    Linder, Ragnar
    IQVIA, Solna, Sweden.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Ferrara, Giovanni
    Karolinska Univ Hosp, Stockholm, Sweden.
    Disease characteristics and outcomes in a Swedish cohort of patients with pulmonary fibrosis (PF)2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 89. Spruit, Martijn A.
    et al.
    Marvisi, Maurizio
    Coolen, Johan
    Poletti, Venerino
    Gasparini, Stefano
    Ställberg, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Herth, Felix J. F.
    Clini, Enrico M.
    Clinical highlights from the 2013 ERS Congress in Barcelona2014In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 44, no 1, p. 198-206Article in journal (Refereed)
    Abstract [en]

    This article reviews a selection of scientific presentations in the area of clinical problems, which were presented at the 2013 European Respiratory Society Annual Congress in Barcelona, Spain. This article discusses the most relevant topics of interest in the field of clinical respiratory medicine, including breakthrough reports and studies of particular interest to the healthcare professionals. Topics are presented and discussed in the context of the most up-to-date literature, including basic science and translational research. In particular, the reviewed topics deal with the areas of complex chronic obstructive pulmonary disease and asthma (even in the primary care setting), idiopathic pulmonary fibrosis (pathogenesis and therapy), advances in functional chest imaging, interventional pulmonology, pulmonary rehabilitation and chronic care.

  • 90.
    Storaas, Torgeir
    et al.
    Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norway.;Haukeland Hosp, Dept Otolaryngol Head & Neck Surg, N-5021 Bergen, Norway..
    Zock, Jan-Paul
    Ctr Res Environm Epidemiol CREAL, Barcelona, Spain..
    Morano, Ana Espinosa
    Ctr Res Environm Epidemiol CREAL, Barcelona, Spain..
    Holm, Mathias
    Sahlgrens Univ Hosp, Occupat & Environm Med, Gothenburg, Sweden..
    Bjornsson, Eythor
    Univ Hosp, Landspitali, Dept Resp Med & Sleep, Reykjavik, Iceland..
    Forsberg, Bertil
    Umea Univ, Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umea, Sweden..
    Gislason, Thorarinn
    Univ Iceland, Fac Med, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Dept Resp Med & Sleep, Landspitali, Reykjavik, Iceland..
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Norbäck, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Omenaas, Ernst
    Haukeland Hosp, Clin Res Ctr, N-5021 Bergen, Norway..
    Schlunssen, Vivi
    Aarhus Univ, Dept Publ Hlth, Sect Environm Occupat & Hlth, Aarhus, Denmark..
    Toren, Kjell
    Sahlgrens Univ Hosp, Occupat & Environm Med, Gothenburg, Sweden..
    Svanes, Cecilie
    Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norway.;Univ Bergen, Ctr Int Hlth, Bergen, Norway..
    Incidence of rhinitis and asthma related to welding in Northern Europe2015In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 46, no 5, p. 1290-1297Article in journal (Refereed)
    Abstract [en]

    Welding-related asthma is well recognised but less is known about rhinitis in relation to welding. The aim here, was to study associations between welding, rhinitis and asthma in a general population sample, and factors influencing selection into and out of a welding occupation. Adult-onset asthma and non-infectious rhinitis were investigated in the international multicentre population-based Respiratory Health in Northern Europe (RHINE) study, including 16191 responders aged 26-54 years. Ever welding (n=2181), welding >25% of working time (n=747), and welding in stainless steel >6 months (n=173) were assessed by questionnaire. Subjects with rhinitis or asthma onset when aged <18 years were excluded. Incidence rates for asthma and rhinitis were calculated from year of disease onset, and start and end of welding job. Cox's proportional hazard models adjusting for age, sex, parental education and study centre, and Kaplan-Meier curves were used. Rhinitis incidence was higher among welders (hazard ratio (HR) 1.4, 95% CI 1.3-1.6), consistent in men and women, and across centres (pheterogeneity=0.4). In men, asthma incidence was higher among welders (HR 1.4, 95% CI 1.04-1.97). Quitting welding was indicated higher after adult-onset rhinitis (HR 1.1, 95% CI 1.0-1.3). Adult-onset rhinitis and asthma was higher among welders, consistent across population samples from Northern Europe. No pre-employment selection was found, whereas selection out of welding jobs was suggested.

  • 91.
    Ställberg, Björn
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Högman, Marieann
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Bröms, Kristina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Lisspers, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Prediction of future COPD exacerbations - DOSE index or a history of exacerbations?2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 92.
    Sundbom, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Lindberg, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Almqvist, Catarina
    Karolinska Inst, Stockholm, Sweden.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Asthma control and asthma severity in relation to sleep disturbances: Results of the LifeGene study2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 93.
    Swedin, Linda
    et al.
    Karolinska Institutet.
    Neimert Andersson, Theresa
    Karolinska Institutet.
    Hjoberg, Josephine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Jonasson, Sofia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Van Hage, Marianne
    Karolinska Institutet.
    Adner, Mikael
    Karolinska Institutet.
    Ryrfeldt, Åke
    Karolinska Institutet.
    Dahlén, Sven-Erik
    Karolinska Institutet.
    Dissociation of airway inflammation and hyperresponsiveness by cyxloogynease inhibition in allergen challenged mice2009In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 34, no 1, p. 200-208Article in journal (Refereed)
    Abstract [en]

    The aim of the current study was to define how cyclooxygenase (COX)-activity affects airway hyperresponsiveness (AHR) and inflammation using interventions with COX inhibitors at different time points during allergen challenge and/or prior to measurement of AHR in an eosinophil-driven allergic mouse model. Inflammatory cells were assessed in bronchioalveolar lavage (BAL) and AHR was evaluated as the total lung resistance to methacholine (MCh) challenge. Administration of FR122047 (COX-1 inhibitor) during ovalbumin (OVA) challenge and prior to MCh challenge enhanced AHR without affecting the inflammatory cell response. In contrast, administration of lumiracoxib (COX-2 inhibitor) during the same time period had no effect on AHR but reduced the inflammatory cells in BAL. Nonselective COX inhibition with diclofenac both enhanced the AHR and reduced the inflammatory cells. Administration of diclofenac only during OVA challenge reduced the cells in BAL without any changes in AHR, whereas administration of diclofenac only prior to MCh challenge enhanced AHR but did not affect the cells in BAL. The present study implicates distinct roles of prostanoids generated along the COX-1 and COX-2 pathways and, furthermore, that inflammatory cells in BAL do not change in parallel with AHR. These findings support the fact that AHR and the inflammatory response are distinct and, at least in part, uncoupled events.

  • 94.
    Theorell-Haglöw, Jenny
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Berne, Christian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Lindberg, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Obstructive sleep apnoea is associated with decreased insulin sensitivity in females2008In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 31, no 5, p. 1054-60Article in journal (Refereed)
    Abstract [en]

    The aim of the present study was to assess associations between obstructive sleep apnoea and insulin sensitivity in a population-based sample of females. In total, 400 females aged 20-70 yrs underwent a full-night polysomnography, fasting blood sampling, measurement of anthropometric variables and oral glucose tolerance test with measurement of the insulin response (n = 358). The apnoea/hypopnoea index (AHI) was calculated from the results of the polysomnography. From the results of the oral glucose tolerance test, an insulin sensitivity index (ISI) was calculated. Females with an AHI < 5 (n = 119) had a mean+/-SD ISI of 8.3+/-3.8, whereas females with an AHI > or = 30 (n = 34) had an ISI of 6.2+/-4.0. Nocturnal minimal saturation was independently associated with decreased insulin sensitivity when controlling for age, waist/hip ratio, level of physical activity, smoking and alcohol consumption (95% confidence interval (CI) 0.004-0.14). When adjusting for confounders, the AHI was associated with increased fasting and 2-h insulin levels (95% CI 0.14-0.99 and 95% CI 0.28-6.47, respectively). Obstructive sleep apnoea was found to be independently associated with decreased insulin sensitivity in the present population-based sample of females.

  • 95.
    Thornadtsson, Alexandra
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Bröms, Kristina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
    Lisspers, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Ställberg, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Högman, Marieann
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Clinical correlates of alveolar nitric oxide in COPD2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 96.
    Timm, Signe
    et al.
    Aarhus Univ, Aarhus, Denmark.
    Frydenberg, Morten
    Aarhus Univ, Aarhus, Denmark.
    Abrahamson, Michael
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
    Bertelsen, Randi
    Univ Bergen, Bergen, Norway.
    Bråbäck, Lennart
    Umeå Univ, Umeå, Sweden.
    Benediktsdottir, Bryndis
    Univ Reykjavik Univ, Reykjavik, Iceland.
    Dharmage, Shyamali
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
    Forsberg, Bertil
    Umeå Univ, Umeå, Sweden.
    Gislason, Thorarinn
    Univ Reykjavik, Reykjavik, Iceland.
    Holm, Mathias
    Sahlgrens Univ Hosp, Gothenburg, Sweden.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Jogi, Rain
    Univ Tartu, Tartu, Estonia.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Ramos, Jose
    Univ Huelva, Huelva, Spain.
    Sigsgaard, Torben
    Univ Aarhus, Aarhus, Denmark.
    Svanes, Cecilie
    Univ Bergen, Bergen, Norway.
    Schlunssen, Vivi
    Aarhus Univ, Aarhus, Denmark.
    Asthma and selective migration away from farming environments in a three-generation cohort study2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 97.
    Troosters, Thierry
    et al.
    Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
    Langer, Daniel
    Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
    Burtin, Chris
    Hasselt Univ, Fac Rehabil, BIOMED Biomed Res Inst, REVAL Rehabil Res Ctr, Diepenbeek, Belgium.
    Chatwin, Michelle
    Royal Brompton & Harefield NHS Fdn Trust, Acad & Clin Dept Sleep & Breathing, London, England;Royal Brompton & Harefield NHS Fdn Trust, NIHR Resp Biomed Res Unit, London, England.
    Clini, Enrico M.
    Univ Modena & Reggio Emilia, Dept Med & Surg Sci, Modena, Italy;Univ Hosp Modena Policlin, Modena, Italy.
    Emtner, Margareta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    Gosselink, Rik
    Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
    Grant, Kathleen
    Vaud Univ Hosp, Dept Cardioresp Physiotherapy, Lausanne, Switzerland.
    Inal-Ince, Deniz
    Hacettepe Univ, Fac Hlth Sci, Dept Physiotherapy & Rehabil, Ankara, Turkey.
    Lewko, Agnieszka
    Kingston Univ, Fac Hlth Social Care & Educ, Dept Rehabil Sci, London, England;St Georges Univ London, London, England.
    Main, Eleanor
    UCL, Great Ormond St Inst Child Hlth, Physiotherapy Dept, London, England.
    Oberwaldner, Beatrice
    Med Univ, Postgrad Sch, Graz, Austria.
    Tabin, Nathalie
    European Resp Soc, Educ Dept, Lausanne, Switzerland.
    Pitta, Fabio
    State Univ Londrina UEL, Lab Res Resp Physiotherapy LFIP, Dept Physiotherapy, Londrina, Brazil.
    A guide for respiratory physiotherapy postgraduate education: presentation of the harmonised curriculum2019In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 53, no 6, article id 1900320Article in journal (Other academic)
  • 98. Troosters, Thierry
    et al.
    Pitta, Fabio
    Oberwaldner, Beatrice
    Lewko, Agnieszka
    Inal-Ince, Deniz
    Grant, Kathleen
    Gosselink, Rik
    Burtin, Chris
    Emtner, Margareta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
    Clini, Enrico
    Chatwin, Michelle
    Mitchell, Sharon
    Development of a syllabus for postgraduate respiratory physiotherapy education: the Respiratory Physiotherapy HERMES project2015In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 45, no 5, p. 1221-1223Article in journal (Other academic)
  • 99.
    Tsolakis, Nikolaos
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Alving, Kjell
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Biomarker-assisted characterisation of non-type 2 disease in young asthmatics2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
  • 100. Verbanck, Sylvia
    et al.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
    George, Steven
    Gelb, Arthur F
    Vincken, Walter
    Van Muylem, Alain
    Bronchial and alveolar components of exhaled nitric oxide and their relationship2012In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 39, no 5, p. 1258-1261Article in journal (Refereed)
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