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  • 51.
    Bejhed Stjernberg, Rebecca
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Svedlindh, Peter
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Ahlford, Annika
    Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Solna, Sweden..
    Strömberg, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Magnetic nanobeads present during enzymatic amplification and labeling for a simplified DNA detection protocol based on AC susceptometry2015Inngår i: AIP Advances, ISSN 2158-3226, E-ISSN 2158-3226, Vol. 5, nr 12, artikkel-id 127139Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Magnetic biosensors are promising candidates for low-cost point-of-care biodiagnostic devices. For optimal efficiency it is crucial to minimize the time and complexity of the assay protocol including target recognition, amplification, labeling and read-out. In this work, possibilities for protocol simplifications for a DNA biodetection principle relying on hybridization of magnetic nanobeads to rolling circle amplification (RCA) products are investigated. The target DNA is recognized through a padlock ligation assay resulting in DNA circles serving as templates for the RCA process. It is found that beads can be present during amplification without noticeably interfering with the enzyme used for RCA (phi29 polymerase). As a result, the bead-coil hybridization can be performed immediately after amplification in a one-step manner at elevated temperature within a few minutes prior to read-out in an AC susceptometer setup, i.e. a combined protocol approach. Moreover, by recording the phase angle xi = arctan(chi ''/chi'), where chi and chi '' are the in-phase and out-of-phase components of the AC susceptibility, respectively, at one single frequency the total assay time for the optimized combined protocol would be no more than 1.5 hours, often a relevant time frame for diagnosis of cancer and infectious disease. Also, applying the phase angle method normalization of AC susceptibility data is not needed. These findings are useful for the development of point-of-care biodiagnostic devices relying on bead-coil binding and magnetic AC susceptometry.

  • 52.
    Bjärnhall Prytz, Nicklas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Interactions of cellulose and aromatic organic molecules modelled with density functional theory: A computational study2015Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [en]

    In this study, the interaction energies between aromatic organic molecules (AOMs) and cellulose are explored using density functional theory (DFT) through the software SIESTA and the exchange-correlational functional VDW-DRSLL. Three AOMs will be modelled: benzene, benzamide and benzoic acid. Firstly, the interaction energies of the dimers of the AOMs are determined. Then, the obtained interaction energies of the cellulose-AOM complexes are compared to the former in order to decide which interaction is stronger. It is found that the studied AOMs are more likely to interact with cellulose than with another identical monomer; benzamide has the highest propensity to interact, followed by benzoic acid and benzene. Furthermore, for all interaction energy calculations a counterpoise correction term will be introduced as an addition to the SIESTA optimisation and it will be shown that without this correction the acquired energy minima will deviate significantly from accepted values from previous studies.

  • 53.
    Blasi Romero, Anna
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Nguyen, Hugo
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Mikrosystemteknik.
    Barbe, Laurent
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Mikrosystemteknik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Tenje, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Mikrosystemteknik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Mestres, Gemma
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Mikrosystemteknik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Development and validation of a reusable microfluidic system for the evaluation of biomaterials’ biological properties2019Konferansepaper (Annet vitenskapelig)
  • 54.
    Blom, Magnus
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Syntetisk organisk kemi.
    Huang, Hao
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Gogoll, Adolf
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi, Organisk kemi I.
    Photoswitchable peptidomimetics with a stiff-stilbene chromophore for inhibition of Mycobacterium tuberculosis RNRManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Peptidomimetics incorporating two amino acids 1 and 2 with a stiff stilbene chromophore have been screened by a computational study and compared to a previously investigated analog 3 with stilbene chromophore. The effect of E-Z isomerization of the chromophores on the conformational properties of the petidomimetics was assessed via the frequency of hydrogen bonding between the two peptide strands attached to either side of the chromophore. Substantial differences between the three amino acids were thus indicated, in line with the anticipated effect of chromophore rigidity variation.

  • 55.
    Blom, Magnus
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Syntetisk organisk kemi.
    Huang, Hao
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Gogoll, Adolf
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Syntetisk organisk kemi.
    Synthesis and characterization of photoswitchable stiff-stilbene based amino acid derivativesManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Synthetic routes towards the Boc-protected amino acids 1 and 2 incorporating the stiff stilbene chromophore via the corresponding indanone carboxylic acids have been devised. Crucial steps are a reductive McMurry coupling of the indanone carboxylic acids, yielding stiff stilbene dicarboxylic acid esters. Hydrolysis to the monoester and conversion to the azides, followed by a Curtius rearrangement afforded the Boc-protected amino acid ester 1.

  • 56.
    Blom, Magnus
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Syntetisk organisk kemi.
    Norrehed, Sara
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Syntetisk organisk kemi.
    Andersson, Claes-Henrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Syntetisk organisk kemi.
    Huang, Hao
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Light, Mark E.
    Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, U.K.
    Bergquist, Jonas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Grennberg, Helena
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Fysikalisk-organisk kemi.
    Gogoll, Adolf
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Syntetisk organisk kemi.
    Synthesis and Properties of Bis-Porphyrin Molecular Tweezers: Effects of Spacer Flexibility on Binding and Supramolecular Chirogenesis2016Inngår i: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 21, nr 1Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Abstract: Ditopic binding of various dinitrogen compounds to three bisporphyrin molecular tweezers with spacers of varying conformational rigidity, incorporating the planar ene-diyne (1), the helical stiff stilbene (2), or the semirigid glycoluril motif fused to  the porphyrins (3) are compared. Binding constants Ka = 10^4 to 10^6 M^-1 reveal subtle  differences between these tweezers, that are discussed in terms of porphyrin dislocation  modes. Exciton coupled circular dichroism (ECCD) of complexes with chiral dinitrogen  guests provides experimental evidence for the conformational properties of the tweezers. The results are further supported and rationalized by conformational analysis.

  • 57.
    Blom, Tobias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Coronel, Ernesto
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Surpi, Alexandro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Östlund, Fredrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Michler, J.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Nanocontact Fabrication and Characterization2007Konferansepaper (Fagfellevurdert)
  • 58.
    Blom, Tobias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Jafri, Hassan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Systematic assessment of trapped gold nanoparticles in a nanogap platform for electrical characterization of conducting and non-conducting moleculesManuskript (preprint) (Annet vitenskapelig)
  • 59.
    Blom, Tobias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Jafri, Hassan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Coronel, E.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Grigeriev, A.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Dielectrophoretic trapping of gold nanoparticles on SAM-prepared nanogaps: A comparative study of different molecular systems2009Inngår i: presentation European Conference on Molecular Electronics (ECME2009), Copenhagen, Denmark (Sept 2009), 2009Konferansepaper (Annet vitenskapelig)
  • 60.
    Blom, Tobias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Jafri, Hassan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Dielectrophoretic trapping of gold nanoparticles on SAM-prepared nanogaps: A comparative study of different molecular systems2010Inngår i: International Conference on Molecular Electronics, Emmetten, Switzerland (Jan 2010), 2010Konferansepaper (Fagfellevurdert)
  • 61.
    Blom, Tobias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Jafri, Hassan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Electrophoretic trapping of gold nanoparticles on sam-prepared nanogaps: A comparative study of different molecular systems2009Konferansepaper (Fagfellevurdert)
  • 62.
    Blom, Tobias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Jafri, Hassan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Leifer, Klaus
    Fabrication and characterization of high resistance nanogaps used for studies of different molecular electronics systems2009Konferansepaper (Fagfellevurdert)
  • 63.
    Blom, Tobias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Jafri, Hassan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Using a nanocontact platform for evaluating of molecular electronicsKonferansepaper (Fagfellevurdert)
  • 64.
    Blom, Tobias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Jafri, S. Hassan. M.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Leifer, Klaus
    Fabrication and use of high resistance nanogaps for application in molecular electronics2009Konferansepaper (Fagfellevurdert)
  • 65.
    Blom, Tobias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Coronel, Ernesto
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Fabrication and characterization of highly reproducible, high resistance nanogaps made by focused ion beam milling2007Konferansepaper (Fagfellevurdert)
  • 66.
    Blom, Tobias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Coronel, Ernesto
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Experimentell fysik.
    Fabrication and characterization of highly reproducible, high resistance nanogaps made by focused ion beam milling2008Konferansepaper (Fagfellevurdert)
  • 67.
    Blom, Tobias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Coronel, Ernesto
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Leifer, Klaus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Fabrication and characterization of highly reproducible, high resistance nanogaps made by focused ion beam milling2007Inngår i: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 18, nr 28, s. 285301-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Nanoelectrodes were fabricated combining photolithography, electron beam lithography and focused ion beam milling allowing for large scale integration and nanoengineering of the electrode properties. The structure determination by transmission and scanning electron microscopy showed a highly reproducible gap width. The atomic scale electrode structure was characterized using scanning and transmission electron microscopy. The nanogap resistances were found to be the highest hitherto reported for nanogaps, namely in the 300–1300 TΩ range. Gold nanoparticles were trapped by ac dielectrophoresis, and the electrodes were shown to be stable enough to endure empty gap voltages as high as 5 V as well as currents high enough to induce fusing of trapped nanoparticles.

  • 68. Blomgren, Jakob
    et al.
    Ahrentorp, Fredrik
    Ilver, Dag
    Jonasson, Christian
    Sepehri, Sobhan
    Kalaboukhov, Alexei
    Winkler, Dag
    Zardán Gómez de la Torre, Teresa
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Johansson, Christer
    Development of a Sensitive Induction-Based Magnetic Nanoparticle Biodetection Method.2018Inngår i: Nanomaterials (Basel, Switzerland), E-ISSN 2079-4991, Vol. 8, nr 11, artikkel-id E887Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We developed a novel biodetection method for influenza virus based on AC magnetic susceptibility measurement techniques (the DynoMag induction technique) together with functionalized multi-core magnetic nanoparticles. The sample consisting of an incubated mixture of magnetic nanoparticles and rolling circle amplified DNA coils is injected into a tube by a peristaltic pump. The sample is moved as a plug to the two well-balanced detection coils and the dynamic magnetic moment in each position is read over a range of excitation frequencies. The time for making a complete frequency sweep over the relaxation peak is about 5 minutes (10 Hz⁻10 kHz with 20 data points). The obtained standard deviation of the magnetic signal at the relaxation frequency (around 100 Hz) is equal to about 10-5 (volume susceptibility SI units), which is in the same range obtained with the DynoMag system. The limit of detection with this method is found to be in the range of 1 pM.

  • 69. Bondarenko, Olesja
    et al.
    Torres, Neus Feliu
    Kupferschmidt, Natalia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Garcia-Bennett, Alfonso
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Fadeel, Bengt
    Cellular uptake of mesoporous silica particles is governed by activation state of macrophages2014Inngår i: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 229, s. S188-S188Artikkel i tidsskrift (Fagfellevurdert)
  • 70.
    Brohede, Ulrika
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Atluri, Rambabu
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Garcia Bennett, Alfonso
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Sustained Release from Mesosporous Nanoparticles: evaluation of structural properties associated with controlled release rate2008Inngår i: Current Drug Delivery, ISSN 1567-2018, E-ISSN 1875-5704, Vol. 5, nr 3, s. 177-185Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We present here a detailed study of the controlled release of amino acid derived amphiphilic molecules from the internal pore structure of mesoporous nanoparticle drug delivery systems with different structural properties; namely cubic and hexagonal structures of various degrees of complexity. The internal pore surface of the nanomaterials presented has been functionalised with amine moieties through a one pot method. Release profiles obtained by Alternating Ionic Current measurements are interpreted in terms of specific structural and textural parameters of the porous nanoparticles such as pore geometry and connectivity. Results indicate that diffusion coefficients are lower by as much as four orders of magnitude in 2-dimensional structures in comparison to 3-dimensional mesoporous solids. A fast release in turn is observed from mesocaged materials AMS-9 and AMS-8 where the presence of structural defects is thought to lead to a slightly lower diffusion coefficient in the latter. Amount of pore wall functionalisation and number of binding sites on the model drug are found to have little effect on the drug release rate.

  • 71.
    Brohede, Ulrika
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Forsgren, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Roos, Stefan
    Mihranyan, Albert
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Multifunctional implant coatings providing possibilities for fast antibiotics loading with subsequent slow release2009Inngår i: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 20, nr 9, s. 1859-1867Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The possibility to fast-load biomimetic hydroxyapatite coatings on surgical implant with the antibiotics Amoxicillin, Gentamicin sulfate, Tobramycin and Cephalothin has been investigated in order to develop a multifunctional implant device offering sustained local anti-bacterial treatment and giving the surgeon the possibility to choose which antibiotics to incorporate in the implant at the site of surgery. Physical vapor deposition was used to coat titanium surfaces with an adhesion enhancing gradient layer of titanium oxide having an amorphous oxygen poor composition at the interface and a crystalline bioactive anatase TiO2 composition at the surface. Hydroxyapatite (HA) was biomimetically grown on the bioactive TiO2 to serve as a combined bone in-growth promoter and drug delivery vehicle. The coating was characterized using scanning and transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy. The antibiotics were loaded into the HA coatings via soaking and the subsequent release and antibacterial effect were analyzed using UV spectroscopy and examination of inhibition zones in a Staphylococcus aureus containing agar. It was found that a short drug loading time of 15 min ensured antibacterial effects after 24 h for all antibiotics under study. It was further found that the release processes of Cephalothin and Amoxicillin consisted of an initial rapid drug release that varied unpredictably in amount followed by a reproducible and sustained release process with a release rate independent of the drug loading times under study. Thus, implants that have been fast-loaded with drugs could be stored for ~10 min in a simulated body fluid after loading to ensure reproducibility in the subsequent release process. Calculated release rates and measurements of drug amounts remaining in the samples after 22 h of release indicated that a therapeutically relevant dose could be achieved close to the implant surface for about 2 days. Concluding, the present study provides an outline for the development of a fast-loading slow-release surgical implant kit where the implant and the drug are separated when delivered to the surgeon, thus constituting a flexible solution for the surgeon by offering the choice of quick addition of antibiotics to the implant coating based on the patient need.

  • 72.
    Brohede, Ulrika
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Nilsson, Martin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    The importance of water-cellulose interactions for the drug release process2004Inngår i: The Swedish Academy of Pharmaceutical Sciences conference “Styrning av läkemedelstillförsel aktuell svensk forskning” 2-3 June, Göteborg, contribution P9 (2004), 2004Konferansepaper (Fagfellevurdert)
  • 73.
    Brohede, Ulrika
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Percolating ion transport in binary mixtures with high dielectric loss2006Inngår i: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 88, artikkel-id 214103Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We investigate the ion transportpercolationproperties of a binary system of an ion conductor (NaCl) and an insulator (ethyl cellulose) for which the ac component of the conductivity is non-negligible over the entire measured frequency range. We find that the dc conductivity, extracted from a well-defined range of frequencies, can be described by a low percolation threshold, ϕc=0.06 three-dimensional conducting network. The low ϕc was explained by the water-layer-assisted ion conduction in micrometer-sized ethyl cellulose channels between NaCl grains. The present findings provide valuable knowledge for the analysis and design of a broad class of ion conducting functional materials.

  • 74.
    Brohede, Ulrika
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. Nanoteknologi.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. Nanoteknologi.
    Percolating ion transport in binary mixtures with high dielectric loss: Dry dielectric spectroscopy recordings and wet time-dependent salt release measurements.2006Konferansepaper (Annet vitenskapelig)
  • 75.
    Brohede, Ulrika
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Percolation phenomena in controlled drug release matrices studied by dielectric spectroscopy and the alternating ionic current method2007Inngår i: Journal of Non-Crystalline Solids, ISSN 0022-3093, E-ISSN 1873-4812, Vol. 353, nr 47-51, s. 4506-4514Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The combined radial and axial ionic drug release from – as well as the percolating ionic conductivity in – cylindrical tablets was investigated by the alternating ionic current (AIC) method and dielectric spectroscopy (DS), respectively. The binary tablets consisted of mixtures of insulating ethyl cellulose and the poor ionic conductor model drug NaCl at nine different concentrations. We found that the dc conductivity, extracted from DS in a well-defined range of frequencies by a power-law method, could be described by a NaCl volume fraction percolation threshold of 0.06 in a 3D conducting network. The low threshold was explained by water-layer-assisted ion conduction in μm-sized ethyl cellulose channels between NaCl grains as probed by Hg porosimetry and SEM. The drug release process, as probed by AIC, could be described by a matrix porosity percolation threshold of 0.22, equivalent to a NaCl volume fraction of 0.13. The higher percolation threshold found in the drug release experiments as compared to the DS recordings could be explained by the different probing mechanisms of the analysis methods. The present study should provide valuable knowledge for the analysis of a broad class of ion conducting systems for which the frequency response of the dc ion conductivity is superimposed on other dielectric processes in the dielectric spectrum. It also brings forward knowledge important for the development of controlled drug-delivery vehicles as the presented findings show that the drug release from matrix tablets with unsealed tablet walls substantially differs from earlier investigated release processes for which the drug has only been allowed to escape through one of the flat tablet surfaces.

  • 76.
    Brohede, Ulrika
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Valizadeh, Sima
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Frenning, Göran
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaci.
    Percolative drug diffusion from cylindrical matrix systems with unsealed boundaries2007Inngår i: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 96, nr 11, s. 3087-3099Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Release of NaCl in both the axial and radial directions from cylindrical ethyl cellulose tablets were investigated by the alternating ionic current method. The pore structure of the investigated binary mixtures was examined by mercury porosimetry and scanning electron microscopy, and the nm range fractal surface dimension of tablet pore walls was extracted from krypton gas adsorption isotherms. The drug release was shown to consist of two overlapping processes of which the first was ascribed to dissolution of NaCl close to the tablet boundary followed by subsequent diffusion through a thin ethyl cellulose layer and a second from which a porosity percolation threshold of 0.22 could be extracted. As well, a cross-over to effective-medium behaviour at a porosity of 0.44 was observed. The presented findings showed that drug release from matrix tablets with unsealed tablet walls substantially differs from earlier investigated release processes for which the drug has only been allowed to escape through one of the flat tablet surfaces. Thus, the present study brings forward knowledge important for the tailoring of controlled drug delivery vehicles with optimum release patterns.

  • 77.
    Brohede, Ulrika
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Zhao, Shuxi
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Lindberg, Fredrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Mihranyan, Albert
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Forsgren, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    A novel graded bioactive high adhesion implant coating2009Inngår i: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 255, nr 17, s. 7723-7728Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

     One method to increase the clinical success rate of metal implants is to increase their bone bonding properties, i.e. to develop a bone   bioactive surface leading to reduced risks of interfacial problems.   Much research has been devoted to modifying the surface of metals to   make them become bioactive. Many of the proposed methods include   depositing a coating on the implant. However, there is a risk of coating failure due to low substrate adhesion. This paper describes a method to obtain bioactivity combined with a high coating adhesion via   a gradient structure of the coating. Gradient coatings were deposited   on Ti (grade 5) using reactive magnetron sputtering with increasing   oxygen content. To increase the grain size in the coating, all coatings   were post annealed at 385 degrees C. The obtained coating exhibited a gradual transition over 70 nm from crystalline titanium oxide (anatase)  at the surface to metallic Ti in the substrate, as shown using  cross-section transmission electron microscopy and X-ray photoelectron   spectroscopy depth pro. ling. Using scratch testing, it could be shown that the adhesion to the substrate was well above 1 GPa. The bioactivity of the coating was verified in vitro by the spontaneous   formation of hydroxylapatite upon storage in phosphate buffer solution at 37 degrees C for one week.   The described process can be applied to implants irrespective of bulk  metal in the base and should introduce the possibility to create safer permanent implants like reconstructive devices, dental, or spinal implants.

  • 78.
    Brohede, Ulrika
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Zhao, Suxi
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Lindberg, Fredrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Mihranyan, Albert
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Bioactive coatings on metal implants combined with drug delivery features2008Konferansepaper (Fagfellevurdert)
  • 79.
    Burza, Matthias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Time Resolved Studies of Buried Interfaces by means of Nonlinerar Optics2007Rapport (Annet (populærvitenskap, debatt, mm))
  • 80.
    Burza, Matthias
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Mukhtar, E
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Molecular dynamics of biomimetic ionomers studied using second harmonic generation2006Konferansepaper (Annet vitenskapelig)
  • 81.
    Cai, Yanling
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Titanium Dioxide Photocatalysis in Biomaterials Applications2013Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Despite extensive preventative efforts, the problem of controlling infections associated with biomedical materials persists. Bacteria tend to colonize on biocompatible materials and form biofilms; thus, novel biomaterials with antibacterial properties are of great interest. In this thesis, titanium dioxide (TiO2)-associated photocatalysis under ultraviolet (UV) irradiation was investigated as a strategy for developing bioactivity and antibacterial properties on biomaterials. Although much of the work was specifically directed towards dental materials, the results presented are applicable to a wide range of biomaterial applications.

    Most of the experimental work in the thesis was based on a resin-TiO2 nanocomposite that was prepared by adding 20 wt% TiO2 nanoparticles to a resin-based polymer material. Tests showed that the addition of the nanoparticles endowed the adhesive material with photocatalytic activity without affecting the functional bonding strength. Subsequent studies indicated a number of additional beneficial properties associated with the nanocomposite that appear promising for biomaterial applications. For example, irradiation with UV light induced bioactivity on the otherwise non-bioactive nanocomposite; this was indicated by hydroxyapatite formation on the surface following soaking in Dulbecco’s phosphate-buffered saline. Under UV irradiation, the resin-TiO2 nanocomposite provided effective antibacterial action against both planktonic and biofilm bacteria. UV irradiation of the nanocomposite also provided a prolonged antibacterial effect that continued after removal of the UV light source. UV treatment also reduced bacterial adhesion to the resin-TiO2 surface.

    The mechanisms involved in the antibacterial effects of TiO2 photocatalysis were studied by investigating the specific contributions of the photocatalytic reaction products (the reactive oxygen species) and their disinfection kinetics. Methods of improving the viability analysis of bacteria subjected to photocatalysis were also developed. 

    Delarbeid
    1. Dental adhesives with bioactive and on-demand bactericidal properties
    Åpne denne publikasjonen i ny fane eller vindu >>Dental adhesives with bioactive and on-demand bactericidal properties
    2010 (engelsk)Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 26, nr 5, s. 491-499Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Objectives: The aim of the present work was to perform the first in vitro evaluation of a new interfacial bond-promoting material-and-method concept for on-demand long term bacteria inhibition in dental restoration procedures. Methods: The bioactivity, mechanical bonding strength and photocatalytic bactericidal properties, induced by low dose ultraviolet-A (UV-A) irradiation of dental adhesives containing crystalline titania nanoparticles (NPs), were analyzed. Results: Dental adhesives with a NP content of 20 wt% were shown to be bioactive in terms of spontaneous hydroxylapatite formation upon storage in simulated body fluid and the bioactivity was found to be promoted by chemical etching of the adhesives. The mechanical bonding strength between the adhesives and a HA tooth model was shown to be unaffected by the NPs up to a NP content of 30 wt%. Elimination of Staphylococcus epidermidis in contact with the adhesives was found to depend both on UV photocatalytic irradiation intensity and time. Efficient elimination of the bacteria could be achieved using a UV-A dose of 4.5 J/cm2 which is about 6 times below the safe maximum UV dose according to industry guidelines, and 20 times below the average UV-A dose received during an ordinary sun bed session. Significance: The combined features of bioactivity and on-demand bactericidal effect should open up the potential to create dental adhesives that reduce the incidence of secondary caries and promote closure of gaps forming at the interface towards the tooth via remineralization of adjacent tooth substance, as well as prevention of bacterial infections via on-demand UV-A irradiation.

    Emneord
    Antibacterial, Bioactivity, Dental adhesive, Nanoparticles, Photocatalysis, Titanium oxide
    HSV kategori
    Forskningsprogram
    Materialvetenskap
    Identifikatorer
    urn:nbn:se:uu:diva-121515 (URN)10.1016/j.dental.2010.01.008 (DOI)000275815300012 ()20189237 (PubMedID)
    Tilgjengelig fra: 2010-03-24 Laget: 2010-03-24 Sist oppdatert: 2018-02-08bibliografisk kontrollert
    2. Photocatalysis induces bioactivity of an organic polymer based material
    Åpne denne publikasjonen i ny fane eller vindu >>Photocatalysis induces bioactivity of an organic polymer based material
    Vise andre…
    2014 (engelsk)Inngår i: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 4, nr 101, s. 57715-57723Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Several materials, like bioglasses, sintered hydroxyapatite and Ti metals and alloys, have the ability to bond to living bone in vivo, which is a desirable property of biomaterials called bioactivity. In this work, we present a novel strategy to develop bioactivity on the non-bioactive surface of a resin-TiO2 nanocomposite through photocatalysis. The results show that UV irradiation (365 nm, 10 mW cm(-2)) for 8 to 16 h on the resin-TiO2 nanocomposite immersed in water induces bioactivity as indicated by hydroxyapatite growth following immersion of the samples in Dulbecco's phosphate buffered saline for 7 days at 37 degrees C. While a nonirradiated resin-TiO2 surface did not show any hydroxyapatite deposition, a surface after 16 h of UV irradiation was fully covered by hydroxyapatite. In vitro cell adhesion of osteoblast-like MG63 cells confirmed the biocompatibility and bioactivity of the resin-TiO2 surfaces with a hydroxyapatite deposition layer, while the non-irradiated resin-TiO2 surface showed no cell adhesion. Resin-TiO2 nanocomposites, with or without UV irradiation, proved to be nontoxic to two human cell lines, human dermal fibroblasts (hDF) and MG63 cells. It was also shown that an increased dose of UV irradiation decreased bacterial adhesion, which is an additional benefit of the UV treatment and a favourable property for biomedical applications. The combined benefits of biocompatibility, bioactivity, decreased bacterial adhesion and the highly efficient disinfection property of TiO2 photocatalysis under UV light make this resin-TiO2 material an interesting candidate for implant and biomedical device applications.

    HSV kategori
    Identifikatorer
    urn:nbn:se:uu:diva-197798 (URN)10.1039/c4ra08805k (DOI)000345651600048 ()
    Tilgjengelig fra: 2013-04-04 Laget: 2013-04-04 Sist oppdatert: 2018-02-08bibliografisk kontrollert
    3. A Method for Quantitative Determination of Biofilm Viability
    Åpne denne publikasjonen i ny fane eller vindu >>A Method for Quantitative Determination of Biofilm Viability
    2012 (engelsk)Inngår i: Journal of Functional Biomaterials, ISSN 2079-4983, Vol. 3, nr 2, s. 418-431Artikkel i tidsskrift (Fagfellevurdert) Published
    HSV kategori
    Forskningsprogram
    Teknisk fysik med inriktning mot nanoteknologi och funktionella material
    Identifikatorer
    urn:nbn:se:uu:diva-182501 (URN)10.3390/jfb3020418 (DOI)
    Tilgjengelig fra: 2012-10-11 Laget: 2012-10-11 Sist oppdatert: 2016-11-30bibliografisk kontrollert
    4. Bacteria viability assessment after photocatalytic treatment
    Åpne denne publikasjonen i ny fane eller vindu >>Bacteria viability assessment after photocatalytic treatment
    2014 (engelsk)Inngår i: 3 Biotech, ISSN 2190-5738, E-ISSN 2190-5738, Vol. 4, nr 2, s. 149-157Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    The aim of the present work was to evaluate several methods for analyzing the viability of bacteria after antibacterial photocatalytic treatment. Colony-forming unit (CFU) counting, metabolic activity assays based on resazurin and phenol red and the Live/Dead® BacLight™ bacterial viability assay (Live/Dead staining) were employed to assess photocatalytically treated Staphylococcus epidermidis and Streptococcus mutans. The results showed conformity between CFU counting and the metabolic activity assays, while Live/Dead staining showed a significantly higher viability post-treatment. This indicates that the Live/Dead staining test may not be suitable for assessing bacterial viability after photocatalytic treatment and that, in general, care should be taken when selecting a method for determining the viability of bacteria subjected to photocatalysis. The present findings are expected to become valuable for the development and evaluation of photocatalytically based disinfection applications

    sted, utgiver, år, opplag, sider
    Springer, 2014
    HSV kategori
    Forskningsprogram
    Teknisk fysik med inriktning mot nanoteknologi och funktionella material
    Identifikatorer
    urn:nbn:se:uu:diva-197796 (URN)10.1007/s13205-013-0137-1 (DOI)000358045200005 ()
    Forskningsfinansiär
    Carl Tryggers foundation Göran Gustafsson Foundation for promotion of scientific research at Uppala University and Royal Institute of TechnologySwedish Research CouncilVINNOVASwedish Foundation for Strategic Research
    Tilgjengelig fra: 2013-04-04 Laget: 2013-04-04 Sist oppdatert: 2017-12-06bibliografisk kontrollert
    5. Photocatalytic inactivation of biofilms on bioactive dental adhesives
    Åpne denne publikasjonen i ny fane eller vindu >>Photocatalytic inactivation of biofilms on bioactive dental adhesives
    Vise andre…
    2014 (engelsk)Inngår i: Journal of Biomedical Materials Research. Part B - Applied biomaterials, ISSN 1552-4973, E-ISSN 1552-4981, Vol. 102, nr 1, s. 62-67Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Biofilms are the most prevalent mode of microbial life in nature and are 10-1000 times more resistant to antibiotics than planktonic bacteria. Persistent biofilm growth associated at the margin of a dental restoration often leads to secondary caries, which remains a challenge in restorative dentistry. In this work, we present the first in vitro evaluation of on-demand photocatalytic inactivation of biofilm on a novel dental adhesive containing TiO2 nanoparticles. Streptococcus mutans biofilm was cultured on this photocatalytic surface for 16 h before photocatalytic treatment with ultraviolet-A (UV-A) light. UV-A doses ranging from 3 to 43 J/cm(2) were applied to the surface and the resulting viability of biofilms was evaluated with a metabolic activity assay incorporating phenol red that provided a quantitative measure of the reduction in viability due to the photocatalytic treatments. We show that an UV-A irradiation dose of 8.4 J/cm(2) leads to one order of magnitude reduction in the number of biofilm bacteria on the surface of the dental adhesives while as much as 5-6 orders of magnitude reduction in the corresponding number can be achieved with a dose of 43 J/cm(2). This material maintains its functional properties as an adhesive in restorative dentistry while offering the possibility of a novel dental procedure in the treatment or prevention of bacterial infections via on-demand UV-A irradiation. Similar materials could be developed for the treatment of additional indications such as peri-implantits.

    Emneord
    photocatalysis, titanium dioxide, biofilm inactivation, Streptococcus mutans, metabolic activity assay
    HSV kategori
    Forskningsprogram
    Teknisk fysik med inriktning mot nanoteknologi och funktionella material; Teknisk fysik med inriktning mot materialvetenskap
    Identifikatorer
    urn:nbn:se:uu:diva-197797 (URN)10.1002/jbm.b.32980 (DOI)000328153100007 ()23847027 (PubMedID)
    Forskningsfinansiär
    Carl Tryggers foundation Göran Gustafsson Foundation for promotion of scientific research at Uppala University and Royal Institute of TechnologySwedish Research CouncilVINNOVASwedish Foundation for Strategic Research
    Tilgjengelig fra: 2013-04-04 Laget: 2013-04-04 Sist oppdatert: 2018-02-08bibliografisk kontrollert
    6. Disinfection Kinetics and Contribution ofReactive Oxygen Species When EliminatingBacteria with TiO2 Induced Photocatalysis
    Åpne denne publikasjonen i ny fane eller vindu >>Disinfection Kinetics and Contribution ofReactive Oxygen Species When EliminatingBacteria with TiO2 Induced Photocatalysis
    2014 (engelsk)Inngår i: Journal of Biomaterials and Nanobiotechnology, ISSN 2158-7027, E-ISSN 2158-7043, Vol. 5, nr 3, s. 200-209Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Titania (TiO2) induced photocatalysis has been widely investigated and applied as a disinfectionstrategy in many industrial and clinical applications. Reactive oxygen species (ROS), including hydroxylradicals (•OH), superoxide radicals ( •−2 O ) and hydrogen peroxide (H2O2), generated in thephotocatalytic reaction process are considered to be the active components prompting the bactericidaleffect. In the present work, the kinetics of photocatalytic inactivation of Staphylococcus epidermidisand specific contributions of •OH, •−2 O and H2O2 to the bactericidal process were studiedusing two disinfection settings sutilizing photocatalytic resin-TiO2 nanocomposite surfacesand suspended TiO2 nanoparticles, respectively. In antibacterial tests against S. epidermidis with alayer of bacterial suspension on the resin-TiO2 surfaces, H2O2 was found to be the most efficientROS component contributing to the antibacterial effect. Disinfection kinetics showed a two-stepbehavior with an initial region having a lower disinfection rate followed by a higher rate regionafter 10 min of UV irradiation. By contrast, in antibacterial tests with suspended bacteria andphotocatalytic TiO2 nanoparticles, •OH and H2O2 showed equal significance in the bacterial inactivationhaving a typical Chick-Watson disinfection kinetics behavior with a steady disinfection rate.The results contribute to the understanding of the bactericidal mechanism and kinetics of photocatalyticdisinfection that are essential for designing specific antibacterial applications of photocatalyticmaterials.

    HSV kategori
    Identifikatorer
    urn:nbn:se:uu:diva-197799 (URN)10.4236/jbnb.2014.53024 (DOI)
    Tilgjengelig fra: 2013-04-04 Laget: 2013-04-04 Sist oppdatert: 2017-12-06bibliografisk kontrollert
    7. Post-UV antibacterial properties of a resin-TiO2 nanocomposite
    Åpne denne publikasjonen i ny fane eller vindu >>Post-UV antibacterial properties of a resin-TiO2 nanocomposite
    (engelsk)Artikkel i tidsskrift (Fagfellevurdert) Submitted
    HSV kategori
    Identifikatorer
    urn:nbn:se:uu:diva-197800 (URN)
    Tilgjengelig fra: 2013-04-04 Laget: 2013-04-04 Sist oppdatert: 2013-08-30bibliografisk kontrollert
  • 82.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Analyzing the viability of bacteria after TiO2 induced photocatalysis2012Inngår i: Scandinavian Society for Biomaterials 5th annual meeting, 2012, Uppsala, Sweden, 2012Konferansepaper (Fagfellevurdert)
  • 83.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Analyzing the viability of bacteria after TiO2 induced photocatalysis2012Inngår i: European Cells and Materials, ISSN 1473-2262, E-ISSN 1473-2262, Vol. 23, nr Suppl.5, s. 31-Artikkel i tidsskrift (Fagfellevurdert)
  • 84.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Biofilm elimination and detachment using photocatalytic TiO2 surfaces2011Inngår i: Conference, 2011Konferansepaper (Fagfellevurdert)
  • 85.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Biofilm susceptibility to photocatalytic dental mateirals2011Inngår i: Conference, 2011Konferansepaper (Fagfellevurdert)
  • 86.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Biofilm susceptibility to photocatalytic dental mateirals2011Inngår i: European Cells and Materials, ISSN 1473-2262, E-ISSN 1473-2262, Vol. 21, nr Suppl.1, s. 55-Artikkel i tidsskrift (Fagfellevurdert)
  • 87.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    TiO2 surface for biofilm elimination, quantified by a novel method2012Inngår i: 9th World Biomaterials Congress, June 1-6, Chengdu, China, 2012Konferansepaper (Fagfellevurdert)
  • 88.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Melhus, Åsa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk mikrobiologi och infektionsmedicin, Klinisk bakteriologi.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Photocatalytic inactivation of biofilms on bioactive dental adhesives2014Inngår i: Journal of Biomedical Materials Research. Part B - Applied biomaterials, ISSN 1552-4973, E-ISSN 1552-4981, Vol. 102, nr 1, s. 62-67Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Biofilms are the most prevalent mode of microbial life in nature and are 10-1000 times more resistant to antibiotics than planktonic bacteria. Persistent biofilm growth associated at the margin of a dental restoration often leads to secondary caries, which remains a challenge in restorative dentistry. In this work, we present the first in vitro evaluation of on-demand photocatalytic inactivation of biofilm on a novel dental adhesive containing TiO2 nanoparticles. Streptococcus mutans biofilm was cultured on this photocatalytic surface for 16 h before photocatalytic treatment with ultraviolet-A (UV-A) light. UV-A doses ranging from 3 to 43 J/cm(2) were applied to the surface and the resulting viability of biofilms was evaluated with a metabolic activity assay incorporating phenol red that provided a quantitative measure of the reduction in viability due to the photocatalytic treatments. We show that an UV-A irradiation dose of 8.4 J/cm(2) leads to one order of magnitude reduction in the number of biofilm bacteria on the surface of the dental adhesives while as much as 5-6 orders of magnitude reduction in the corresponding number can be achieved with a dose of 43 J/cm(2). This material maintains its functional properties as an adhesive in restorative dentistry while offering the possibility of a novel dental procedure in the treatment or prevention of bacterial infections via on-demand UV-A irradiation. Similar materials could be developed for the treatment of additional indications such as peri-implantits.

  • 89.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Disinfection Kinetics and Contribution ofReactive Oxygen Species When EliminatingBacteria with TiO2 Induced Photocatalysis2014Inngår i: Journal of Biomaterials and Nanobiotechnology, ISSN 2158-7027, E-ISSN 2158-7043, Vol. 5, nr 3, s. 200-209Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Titania (TiO2) induced photocatalysis has been widely investigated and applied as a disinfectionstrategy in many industrial and clinical applications. Reactive oxygen species (ROS), including hydroxylradicals (•OH), superoxide radicals ( •−2 O ) and hydrogen peroxide (H2O2), generated in thephotocatalytic reaction process are considered to be the active components prompting the bactericidaleffect. In the present work, the kinetics of photocatalytic inactivation of Staphylococcus epidermidisand specific contributions of •OH, •−2 O and H2O2 to the bactericidal process were studiedusing two disinfection settings sutilizing photocatalytic resin-TiO2 nanocomposite surfacesand suspended TiO2 nanoparticles, respectively. In antibacterial tests against S. epidermidis with alayer of bacterial suspension on the resin-TiO2 surfaces, H2O2 was found to be the most efficientROS component contributing to the antibacterial effect. Disinfection kinetics showed a two-stepbehavior with an initial region having a lower disinfection rate followed by a higher rate regionafter 10 min of UV irradiation. By contrast, in antibacterial tests with suspended bacteria andphotocatalytic TiO2 nanoparticles, •OH and H2O2 showed equal significance in the bacterial inactivationhaving a typical Chick-Watson disinfection kinetics behavior with a steady disinfection rate.The results contribute to the understanding of the bactericidal mechanism and kinetics of photocatalyticdisinfection that are essential for designing specific antibacterial applications of photocatalyticmaterials.

  • 90.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Photocatalytic Antibacterial Effects Are Maintained on Resin-Based TiO2 Nanocomposites after Cessation of UV Irradiation2013Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, nr 10, s. e75929-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Photocatalysis induced by TiO2 and UV light constitutes a decontamination and antibacterial strategy utilized in many applications including self-cleaning environmental surfaces, water and air treatment. The present work reveals that antibacterial effects induced by photocatalysis can be maintained even after the cessation of UV irradiation. We show that resin-based composites containing 20% TiO2 nanoparticles continue to provide a pronounced antibacterial effect against the pathogens Escherichia coli, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus mutans and Enterococcus faecalis for up to two hours post UV. For biomaterials or implant coatings, where direct UV illumination is not feasible, a prolonged antibacterial effect after the cessation of the illumination would offer new unexplored treatment possibilities.

  • 91.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Zhang, Peng
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Photocatalysis induces bioactivity of an organic polymer based material2014Inngår i: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 4, nr 101, s. 57715-57723Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Several materials, like bioglasses, sintered hydroxyapatite and Ti metals and alloys, have the ability to bond to living bone in vivo, which is a desirable property of biomaterials called bioactivity. In this work, we present a novel strategy to develop bioactivity on the non-bioactive surface of a resin-TiO2 nanocomposite through photocatalysis. The results show that UV irradiation (365 nm, 10 mW cm(-2)) for 8 to 16 h on the resin-TiO2 nanocomposite immersed in water induces bioactivity as indicated by hydroxyapatite growth following immersion of the samples in Dulbecco's phosphate buffered saline for 7 days at 37 degrees C. While a nonirradiated resin-TiO2 surface did not show any hydroxyapatite deposition, a surface after 16 h of UV irradiation was fully covered by hydroxyapatite. In vitro cell adhesion of osteoblast-like MG63 cells confirmed the biocompatibility and bioactivity of the resin-TiO2 surfaces with a hydroxyapatite deposition layer, while the non-irradiated resin-TiO2 surface showed no cell adhesion. Resin-TiO2 nanocomposites, with or without UV irradiation, proved to be nontoxic to two human cell lines, human dermal fibroblasts (hDF) and MG63 cells. It was also shown that an increased dose of UV irradiation decreased bacterial adhesion, which is an additional benefit of the UV treatment and a favourable property for biomedical applications. The combined benefits of biocompatibility, bioactivity, decreased bacterial adhesion and the highly efficient disinfection property of TiO2 photocatalysis under UV light make this resin-TiO2 material an interesting candidate for implant and biomedical device applications.

  • 92.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Bacteria viability assessment after photocatalytic treatment2014Inngår i: 3 Biotech, ISSN 2190-5738, E-ISSN 2190-5738, Vol. 4, nr 2, s. 149-157Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of the present work was to evaluate several methods for analyzing the viability of bacteria after antibacterial photocatalytic treatment. Colony-forming unit (CFU) counting, metabolic activity assays based on resazurin and phenol red and the Live/Dead® BacLight™ bacterial viability assay (Live/Dead staining) were employed to assess photocatalytically treated Staphylococcus epidermidis and Streptococcus mutans. The results showed conformity between CFU counting and the metabolic activity assays, while Live/Dead staining showed a significantly higher viability post-treatment. This indicates that the Live/Dead staining test may not be suitable for assessing bacterial viability after photocatalytic treatment and that, in general, care should be taken when selecting a method for determining the viability of bacteria subjected to photocatalysis. The present findings are expected to become valuable for the development and evaluation of photocatalytically based disinfection applications

  • 93.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Post-UV antibacterial properties of a resin-TiO2 nanocompositeArtikkel i tidsskrift (Fagfellevurdert)
  • 94.
    Cai, Yanling
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Welch, Ken
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Engqvist, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Melhus, Åsa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk bakteriologi.
    A novel dental adhesive with bioactive and on-demand biofilm eliminating properties2010Konferansepaper (Fagfellevurdert)
  • 95.
    Carlsson, Daniel
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Lindh, Jonas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. Uppsala universitet.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Malaise, Jean-Luc
    GE Healthcare.
    On the pore space of agarose-based chromatography media2016Konferansepaper (Fagfellevurdert)
  • 96.
    Carlsson, Daniel O
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Structural and electrochemical properties of functionalized nanocellulose materials and their biocompatibility2014Konferansepaper (Fagfellevurdert)
  • 97.
    Carlsson, Daniel O
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Structural and Electrochemical Properties of Functionalized Nanocellulose Materials and Their Biocompatibility2014Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Nanocellulose has received considerable interest during the last decade because it is renewable and biodegradable, and has excellent mechanical properties, nanoscale dimensions and wide functionalization possibilities. It is considered to be a unique and versatile platform on which new functional materials can be based.

    This thesis focuses on nanocellulose from wood (NFC) and from Cladophora algae (CNC), functionalized with surface charges or coated with the conducting polymer polypyrrole (PPy), aiming to study the influence of synthesis processes on structural and electrochemical properties of such materials and assess their biocompatibility.

    The most important results of the work demonstrated that 1) CNC was oxidized to the same extent using electrochemical TEMPO-mediated oxidation as with conventional TEMPO processes, which may facilitate easier reuse of the reaction medium; 2) NFC and CNC films with or without surface charges were non-cytotoxic as assessed by indirect in vitro testing. Anionic TEMPO-CNC films promoted fibroblast adhesion and proliferation in direct in vitro cytocompatibility testing, possibly due to its aligned fibril structure; 3) Rinsing of PPy-coated nanocellulose fibrils, which after drying into free-standing porous composites are applicable for energy storage and electrochemically controlled ion extraction, significantly degraded the PPy coating, unless acidic rinsing was employed. Only minor degradation was observed during long-term ambient storage; 4) Variations in the drying method as well as type and amount of nanocellulose offered ways of tailoring the porosities of nanocellulose/PPy composites between 30% and 98%, with increments of ~10%. Supercritical CO2-drying generated composites with the largest specific surface area yet reported for nanocellulose/conducting polymer composites (246 m2/g). The electrochemical oxidation rate was found to be controlled by the composite porosity; 5) In blood compatibility assessments for potential hemodialysis applications, heparinization of CNC/PPy composites was required to obtain thrombogenic properties comparable to commercial hemodialysis membranes. The pro-inflammatory characteristics of non-heparinized and heparinized composites were, to some extent, superior to commercial membranes. The heparin coating did not affect the solute extraction capacity of the composite.

    The presented results are deemed to be useful for tuning the properties of systems based on the studied materials in e.g. energy storage, ion exchange and biomaterial applications.

    Delarbeid
    1. Electrochemical TEMPO-mediated Oxidation of Highly Crystalline Nanocellulose in Water
    Åpne denne publikasjonen i ny fane eller vindu >>Electrochemical TEMPO-mediated Oxidation of Highly Crystalline Nanocellulose in Water
    Vise andre…
    2014 (engelsk)Inngår i: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 4, s. 52289-52298Artikkel i tidsskrift (Fagfellevurdert) Published
    HSV kategori
    Identifikatorer
    urn:nbn:se:uu:diva-215088 (URN)
    Tilgjengelig fra: 2014-01-10 Laget: 2014-01-10 Sist oppdatert: 2017-12-06
    2. Translational study between structure and biological response of nanocellulose from wood and green algae
    Åpne denne publikasjonen i ny fane eller vindu >>Translational study between structure and biological response of nanocellulose from wood and green algae
    Vise andre…
    2014 (engelsk)Inngår i: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 4, nr 6, s. 2892-2903Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    The influence of nanostructure on the cytocompatibility of cellulose films is analyzed providing insight into how physicochemical properties of surface modified microfibrillated cellulose (MFC) and Cladophora nanocellulose (CC) affect the materials cytocompatibility. CC is modified through TEMPO-mediated oxidation and glycidyltrimethylammonium chloride (EPTMAC) condensation to obtain anionic and cationic nanocellulose samples respectively, while anionic and cationic MFC samples are obtained by carboxymethylation and EPTMAC condensation respectively. Films of unmodified, anionic and cationic MFC and CC are prepared by vacuum filtration and characterized in terms of specific surface area, pore size distribution, degree of crystallinity, surface charge and water content. Human dermal fibroblasts are exposed to culture medium extracts of the films in an indirect contact cytotoxicity test. Moreover, cell adhesion and viability are evaluated in a direct contact assay and the effects of the physicochemical properties on cell behavior are discussed. In the indirect cytotoxicity test no toxic leachables are detected, evidencing that the CC and MFC materials are non-cytotoxic, independently ofthe chemical treatment that they have been subjected to. The direct contact tests show that carboxymethylated-MFC presents a more cytocompatible profile than unmodified and trimethylammonium-MFC. TEMPO-CC promotes fibroblast adhesion and presents cell viability comparable to the results obtained with the tissue culture material Thermanox. We hypothesize that the distinct aligned nanofiber structure present in the TEMPO-CC films is responsible for the improved cell adhesion. Thus, by controlling the surface properties of cellulose nanofibers, such as chemistry, charge, and orientation, cell adhesion properties can be promoted.

    sted, utgiver, år, opplag, sider
    Royal Society of Chemistry, 2014
    HSV kategori
    Forskningsprogram
    Teknisk fysik med inriktning mot nanoteknologi och funktionella material
    Identifikatorer
    urn:nbn:se:uu:diva-211744 (URN)10.1039/C3RA45553J (DOI)000329037100044 ()
    Tilgjengelig fra: 2013-11-30 Laget: 2013-11-30 Sist oppdatert: 2017-12-06bibliografisk kontrollert
    3. A Comparative Study of the Effects of Rinsing and Aging of Polypyrrole/Nanocellulose Composites on Their Electrochemical Properties
    Åpne denne publikasjonen i ny fane eller vindu >>A Comparative Study of the Effects of Rinsing and Aging of Polypyrrole/Nanocellulose Composites on Their Electrochemical Properties
    2013 (engelsk)Inngår i: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 117, nr 14, s. 3900-3910Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    The effects of polymerization conditions, rinsing, and storage on composites composed of polypyrrole (PPy) and Cladophora nanocellulose in terms of purity, chemical composition, conductivity, and electroactivity were investigated using conductivity measurements, cyclic voltammetry, FTIR-ATR, XPS, and ICP-AES. A clear correlation between rinsing volume and PPy degradation was found using water- or NaCl-rinsing solutions as evidenced by conductivity and electroactivity losses. It was further found, through FTIR-ATR as well as XPS-measurements, that this degradation was caused by incorporation of hydroxyl groups in the PPy-layer. The extent of degradation correlated with a shift in the FTIR-ATR peak around 1300 cm(-1), showing that FTIR-ATR may be used as a quick diagnostic tool to evaluate the extent of degradation. By the use of acidic rinsing solution, this degradation effect was eliminated and resulted in superior samples in terms of both conductivity and electroactivity and also in a more efficient removal of reactants. Upon ambient storage, over a period of 200 days, a gradual decrease in conductivity was found for initially highly conductive samples. The electroactivity, on the other hand, was relatively unaffected by storage, showing that conductivity measurements alone are ineffective to determine the degree of polymer degradation if the water content is not controlled. Also, FTIR-ATR measurements indicated that the oxidation state did not change to any large extent upon storage and that only minor degradation of PPy occurred. The results presented herein thus offer valuable guidelines on how to develop simple and reliable postsynthesis treatments of conducting polymer paper composites with performance fulfilling requirements on stability, electroactivity, and purity in applications such as environmentally friendly energy storage devices and biomedical applications.

    HSV kategori
    Forskningsprogram
    Teknisk fysik med inriktning mot nanoteknologi och funktionella material
    Identifikatorer
    urn:nbn:se:uu:diva-200350 (URN)10.1021/jp3125582 (DOI)000317552700022 ()
    Tilgjengelig fra: 2013-05-28 Laget: 2013-05-27 Sist oppdatert: 2017-12-06
    4. Electroactive nanofibrillated cellulose aerogel composites with tunable structural and electrochemical properties
    Åpne denne publikasjonen i ny fane eller vindu >>Electroactive nanofibrillated cellulose aerogel composites with tunable structural and electrochemical properties
    Vise andre…
    2012 (engelsk)Inngår i: Journal of Materials Chemistry, ISSN 0959-9428, E-ISSN 1364-5501, Vol. 22, nr 36, s. 19014-19024Artikkel i tidsskrift (Fagfellevurdert) Published
    HSV kategori
    Forskningsprogram
    Teknisk fysik med inriktning mot nanoteknologi och funktionella material; Kemi med inriktning mot oorganisk kemi
    Identifikatorer
    urn:nbn:se:uu:diva-182555 (URN)10.1039/C2JM33975G (DOI)000307790300046 ()
    Tilgjengelig fra: 2012-10-11 Laget: 2012-10-11 Sist oppdatert: 2017-12-07
    5. Tailoring porosities and electrochemical properties of composites composed of microfibrillated cellulose and polypyrrole
    Åpne denne publikasjonen i ny fane eller vindu >>Tailoring porosities and electrochemical properties of composites composed of microfibrillated cellulose and polypyrrole
    2014 (engelsk)Inngår i: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 4, nr 17, s. 8489-8497Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Composites of polypyrrole and nanocellulose (PPy/nanocellulose) have a high potential as electrodes in energy-storage devices and as membranes for electrochemically controlled ion-exchange systems. In the present work, it is demonstrated that such composites with 42-72% porosity can be produced by using microfibrillated cellulose (MFC) prepared through enzymatic pretreatment or carboxymethylation, or by using different amounts of MFC in the composite synthesis. Together with previous work, this shows that the porosity of PPy/nanocellulose composites can be tailored from 30 to 98% with increments of similar to 10%. Employing the full porosity range of the composites, it is demonstrated that the electrochemical oxidation rate of the materials depends on their porosity due to limitations in the counter ion diffusion process. By tailoring the porosities of PPy/nanocellulose composites, the electrochemical properties can consequently be controlled. The latter provides new possibilities for the manufacturing of electrochemically controlled ion-extraction and energy storage devices with optimized volumetric energy and power densities.

    HSV kategori
    Forskningsprogram
    Teknisk fysik med inriktning mot nanoteknologi och funktionella material
    Identifikatorer
    urn:nbn:se:uu:diva-221065 (URN)10.1039/c3ra47588c (DOI)000330800300012 ()
    Tilgjengelig fra: 2014-03-26 Laget: 2014-03-25 Sist oppdatert: 2017-12-05
    6. Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification
    Åpne denne publikasjonen i ny fane eller vindu >>Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification
    Vise andre…
    2012 (engelsk)Inngår i: Journal of the Royal Society Interface, ISSN 1742-5689, E-ISSN 1742-5662, Vol. 9, nr 73, s. 1943-1955Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Composites of nanocellulose and the conductive polymer polypyrrole (PPy) are presented as candidates for a new generation of haemodialysis membranes. The composites may combine active ion exchange with passive ultrafiltration, and the large surface area (about 80 m2 g−1) could potentially provide compact dialysers. Herein, the haemocompatibility of the novel membranes and the feasibility of effectively removing small uraemic toxins by potential-controlled ion exchange were studied. The thrombogenic properties of the composites were improved by applying a stable heparin coating. In terms of platelet adhesion and thrombin generation, the composites were comparable with haemocompatible polymer polysulphone, and regarding complement activation, the composites were more biocompatible than commercially available membranes. It was possible to extract phosphate and oxalate ions from solutions with physiological pH and the same tonicity as that of the blood. The exchange capacity of the materials was found to be 600 ± 26 and 706 ± 31 μmol g−1 in a 0.1 M solution (pH 7.4) and in an isotonic solution of phosphate, respectively. The corresponding values with oxalate were 523 ± 5 in a 0.1 M solution (pH 7.4) and 610 ± 1 μmol g−1 in an isotonic solution. The heparinized PPy–cellulose composite is consequently a promising haemodialysis material, with respect to both potential-controlled extraction of small uraemic toxins and haemocompatibility.

    HSV kategori
    Forskningsprogram
    Teknisk fysik med inriktning mot nanoteknologi och funktionella material
    Identifikatorer
    urn:nbn:se:uu:diva-169218 (URN)10.1098/rsif.2012.0019 (DOI)000305810200023 ()22298813 (PubMedID)
    Tilgjengelig fra: 2012-02-24 Laget: 2012-02-24 Sist oppdatert: 2018-05-31bibliografisk kontrollert
  • 98.
    Carlsson, Daniel O
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Ferraz, Natalia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Fellström, Bengt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Njurmedicin.
    Nyholm, Leif
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Oorganisk kemi.
    Mihranyan, Albert
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Towards blood purification applications of polypyrrole and cellulose nanocomposites2013Konferansepaper (Fagfellevurdert)
  • 99.
    Carlsson, Daniel O
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Ferraz, Natalia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Hong, Jaan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Larsson, Rolf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Fellström, Bengt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Rättsmedicin.
    Nyholm, Leif
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Oorganisk kemi.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Mihranyan, Albert
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Conducting Nanocellulose Polypyrrole Membranes Intended for Hemodialysis2012Inngår i: European Cells and Materials, ISSN 1473-2262, E-ISSN 1473-2262, Vol. 23, nr Suppl 5, s. 32-32Artikkel i tidsskrift (Fagfellevurdert)
  • 100.
    Carlsson, Daniel O
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Ferraz, Natalie
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Hong, J
    Larsson, R
    Fellström, Bengt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Njurmedicin.
    Nyholm, Leif
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Oorganisk kemi.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Mihranyan, Albert
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Conduting nanocellulose polypyrrole membranes intended for hemodialysis2012Konferansepaper (Fagfellevurdert)
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