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  • 51.
    Shi, Jingwen
    et al.
    Institute of Environmental Medicine, KI, Stockholm.
    Karlsson, Hanna L.
    Institute of Environmental Medicine, KI, Stockholm.
    Johansson, Katarina
    Institute of Environmental Medicine, KI, Stockholm.
    Gogvadze, Vladimir
    Institute of Environmental Medicine, KI, Stockholm.
    Xiao, Lisong
    Inorganic and Materials Chemistry, University of Cologne, Köln, Tyskland.
    Li, Jiangtian
    Inorganic and Materials Chemistry, University of Cologne, Köln, Tyskland.
    Burks, Terrance
    Functional Materials Microelectronics and Applied Physics, School of Information and Communication Technology, KTH, Kista.
    Garcia-Bennett, Alfonso
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Uheida, Abdusalam
    Functional Materials Microelectronics and Applied Physics, School of Information and Communication Technology, KTH, Kista.
    Muhammed, Mamoun
    Functional Materials Microelectronics and Applied Physics, School of Information and Communication Technology, KTH, Kista.
    Mathur, Sanjay
    Inorganic and Materials Chemistry, University of Cologne, Köln, Tyskland.
    Morgenstern, Ralf
    Institute of Environmental Medicine, KI, Stockholm.
    Kagan, Valerian E.
    Dept of Environmental and Occupational Health, University of Pittsburgh, PA, USA.
    Fadeel, Bengt
    Institute of Environmental Medicine, KI, Stockholm.
    Microsomal Glutathione Transferase 1 Protects Against Toxicity Induced by Silica Nanoparticles but Not by Zinc Oxide Nanoparticles2012Inngår i: ACS Nano, ISSN 1936-0851, E-ISSN 1936-086X, Vol. 6, nr 3, s. 1925-1938Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Microsomal glutathione transferase 1 (MGST1) is an antioxidant enzyme located predominantly in the mitochondrial er membrane and endoplasmk reticulum and has been shown to protect cells from lipid peroxidation induced by a variety of cytostatic drugs and pro-oxidant stimuli. We hypothesized that MGST1 may also protect against nanomaterial-induced cytotoxicity through a specific effect on lipid peroxidation. We evaluated the induction of cytotoxicity and oxidative stress by TiO2, CeO2, SiO2, and ZnO in the human MCF-7 cell line with or without overexpression of MGST1. SiO2 and ZnO nanoparticles caused dose- and time-dependent toxicity, whereas no obvious cytotoxic effects were induced by nanoparticles of TiO2 and CeO2. We also noted pronounced cytotoxicity for three out of four additional SiO2 nanoparticles tested. Overexpression of MGST1 reversed the cytotoxicity of the main SiO2 nanoparticles tested and for one of the supplementary SiO2 nanoparticles but did not protect cells against ZnO-induced cytotoxic effects. The data point toward a role of lipid peroxidation In SiO2 nanoparticle-induced cell death. For ZnO nanoparticles, rapid dissolution was observed, and the subsequent interaction of Zn2+ with cellular targets is likely to contribute to the cytotoxic effects. A direct inhibition of MGST1 by Zn2+ could provide a possible explanation for the lack of protection against ZnO nanoparticles in this model. Our data also showed that SiO2 nanoparticle-induced cytotoxicity is mitigated in the presence of serum, potentially through masking of reactive surface groups by serum proteins, whereas ZnO nanoparticles were cytotoxic both In the presence and in the absence of serum.

  • 52.
    Strømme, Maria
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Atluri, Rambabu
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Brohede, Ulrika
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Frenning, Göran
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaci.
    Garcia-Bennett, Alfonso. E
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Proton Absorption in As-Synthesized Mesoporous Silica Nanoparticles as a Structure-Function Relationship Probing Mechanism2009Inngår i: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 25, nr 8, s. 4306-4310Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A new method to investigate the effect of pore geometry on diffusion processes in mesoporous silica nanoparticles and other types of micro- and mesoporous structures is put forward. The method is based onthe study of proton diffusion from a liquid surrounding the mesoporous particles into the particle pore system. The proton diffusion properties are assessed for a variety of as-synthesized mesoporous nano- and microparticles with two-dimensional and three-dimensional connectivity. Results show that the diffusion coefficients are higher for the proton absorption process than for the release of surfactant template molecules, and that they overall follow the same trend with the more complex three-dimensional mesocaged particles showing the highest diffusion coefficients. The pore geometry (cylindrical pores versus cage-type pores) and structure connectivity are found to play a key role for the effects observed. The results put forward in the present work should offer a valuable tool in the development of porous nanomaterials in a range of applications including the use as catalysis and separation enhancers in the petrochemical industry, as scaffolds for hydrogen storage, and as drug delivery vehicles for sustained release and gene transfection.

  • 53.
    Strømme, Maria
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Brohede, Ulrika
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Atluri, Rambabu
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Garcia Bennett, Alfonso
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Mesoporous silica-based nanomaterials for drug delivery: evaluation of structural properties associated with release rate2009Inngår i: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, ISSN 1939-5116, Vol. 1, nr 1, s. 140-148Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We present here a study of the controlled release of amino acid-derived amphiphilic molecules from the internal pore structure of mesoporous nanoparticle drug delivery systems with different structural properties, namely cubic and hexagonal structures of various degrees of complexity. The internal pore surface of the nanomaterials presented has been functionalised with amine moieties through a one-pot method. Release profiles obtained by conductivity measurements are interpreted in terms of specific structural and textural parameters of the porous nanoparticles, such as pore geometry and connectivity. Results indicate that diffusion coefficients are lower by as much 4 orders of magnitude in two-dimensional structures in comparison to three-dimensional mesoporous solids. A fast release in turn is observed from mesocaged materials AMS-9 and AMS-8, where the presence of structural defects is thought to lead to a slightly lower diffusion coefficient in the latter. We conclude that the use of single or mixed phases of these porous systems can be utilized to provide sustained release over long time periods and expect their use in a variety of formulations.

  • 54. Vallhov, H.
    et al.
    Kupferschmidt, Natalia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Garcia-Bennett, Alfonso E.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Gabrielsson, S.
    Scheynius, A.
    Mesoporous silica particles: Potential delivery system and immunomodulatory adjuvant2009Konferansepaper (Fagfellevurdert)
  • 55. Vallhov, H
    et al.
    Kupherschmidt, Natalia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Gabrielsson, S
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Scheynius, A
    Garcia- Bennett, Alfonso
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Immunomodulatory responses triggered by mesoporous silica particles: A study on human dendritic cells2008Konferansepaper (Fagfellevurdert)
  • 56.
    Vallhov, Helen
    et al.
    Karolinska Institutet.
    Gabrielsson, Susanne
    Karolinska Institutet.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Scheynius, Annika
    Karolinska Institutet.
    Garcia Bennett, Alfonso E
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Mesoporous silica particles induce size dependent effects on human dendritic cells2007Inngår i: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 7, nr 12, s. 3576-3582Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    The effects of mesoporous silica nano- (270 nm) and microparticles (2.5 μm) with surface areas above 500 m2/g were evaluated on human monocyte-derived dendritic cells (MDDC). Size- and concentration-dependent effects were seen where the smaller particles and lower concentrations affected MDDC to a minor degree compared to the larger particles and higher concentrations, both in terms of viability, uptake, and immune regulatory markers. Our findings support the further development of mesoporous silica particles in drug and vaccine delivery systems.

  • 57.
    Vallhov, Helen
    et al.
    Dept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden.
    Kupferschmidt, Natalia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Gabrielsson, Susanne
    Dept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden.
    Paulie, Staffan
    Mabtech AB, Nacka Strand, Sweden.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Garcia-Bennett, Alfonso E.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Scheynius, Annika
    Dept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden.
    Adjuvant Properties of Mesoporous Silica Particles Tune the Development of Effector T Cells2012Inngår i: Small, ISSN 1613-6810, Vol. 8, nr 13, s. 2116-2124Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Alum is the most frequently used adjuvant today, primarily inducing Th2 responses. However, Th1-type responses are often desirable within immune therapy, and therefore the development of new adjuvants is greatly needed. Mesoporous silica particles with a highly ordered pore structure have properties that make them very interesting for future controlled drug delivery systems, such as controllable particle and pore size; they also have the ability to induce minor immune modulatory effects, as previously demonstrated on human-monocyte-derived dendritic cells (MDDCs). In this study, mesoporous silica particles are shown to be efficiently engulfed by MDDCs within 2 h, probably by phagocytic uptake, as seen by confocal microscopy and transmission electron microscopy. A co-culture protocol is developed to evaluate the capability of MDDCs to stimulate the development of naive CD4+ T cells in different directions. The method, involving ELISpot as a readout system, demonstrates that MDDCs, after exposure to mesoporous silica particles (AMS-6 and SBA-15), are capable of tuning autologous naive T cells into different effector cells. Depending on the size and functionalization of the particles added to the cells, different cytokine patterns are detected. This suggests that mesoporous silica particles can be used as delivery vehicles with tunable adjuvant properties, which may be of importance for several medical applications, such as immune therapy and vaccination.

  • 58.
    Vallov, Helen
    et al.
    Karolinska Institutet.
    Gabrielsson, Susanne
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. Nanoteknologi och Funktionella material.
    Scheynius, Annika
    Karolinska Institutet.
    Garcia Bennett, Alfonso
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. Nanoteknologi och Funktionella material.
    Mesoporous Silica Particles Induce Size Dependent Effects on Human Dendritic Cells2007Konferansepaper (Annet (populærvitenskap, debatt, mm))
  • 59. Vallov, Helen
    et al.
    Qin, Jian
    Garcia-Bennett, Alfonso
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. Nanoteknologi och Funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. Nanoteknologi och Funktionella material.
    Mohammad, Mamoun
    Gabrielsson, Susanne
    Scheynius, Annika
    The effect of nanoparticles on human dendritic cells2007Konferansepaper (Fagfellevurdert)
  • 60. Vallov, Helen
    et al.
    Qin, Jian
    Garcia-Bennett, Alfonso
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. Nanoteknologi och Funktionella material.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. Nanoteknologi och Funktionella material.
    Muhammad, Mamoun
    Gabrielsson, Susanne
    Scheynius, Annika
    The effect of nanoparticles on human dendritic cells2007Konferansepaper (Fagfellevurdert)
  • 61. Villaescusa, Luis A
    et al.
    Rodriguez, I
    Mihi, A
    Garcia Bennett, A E
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. Nanoteknologi och funktionella material.
    Miguez, H
    Photonic Crystals of Mesoporous Walls: Hierarchically Ordered Biomodal Porous Silica Films Displaying Optical Bragg Diffraction2005Inngår i: Journal of Material ChemistryArtikkel i tidsskrift (Fagfellevurdert)
  • 62. Witasp, Erika
    et al.
    Kupferschmidt, Natalia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Bengtsson, Linnéa
    Hultenby, Kjell
    Smedman, Christian
    Paulie, Staffan
    Garcia-Bennett, Alfonso E
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Fadeel, Bengt
    Efficient internalization of mesoporous silica particles of different sizes by primary human macrophages without impairment of macrophage clearance of apoptotic or antibody-opsonized target cells2009Inngår i: Toxicology and Applied Pharmacology, ISSN 0041-008X, E-ISSN 1096-0333, Vol. 239, nr 3, s. 306-319Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Macrophage recognition and ingestion of apoptotic cell corpses, a process referred to as programmed cell clearance, is of considerable importance for the maintenance of tissue homeostasis and in the resolution of inflammation. Moreover, macrophages are the first line of defense against microorganisms and other foreign materials including particles. However, there is sparse information on the mode of uptake of engineered nanomaterials by primary macrophages. In this study, mesoporous silica particles with cubic pore geometries and covalently fluorescein-grafted particles were synthesized through a novel route, and their interactions with primary human monocyte-derived macrophages were assessed. Efficient and active internalization of mesoporous silica particles of different sizes was observed by transmission electron microscopic and flow cytometric analysis and studies using pharmacological inhibitors suggested that uptake occurred through a process of endocytosis. Moreover, uptake of silica particles was independent of serum factors. The silica particles with very high surface areas due to their porous structure did not impair cell viability or function of macrophages, including the ingestion of different classes of apoptotic or opsonized target cells. The current findings are relevant to the development of mesoporous materials for drug delivery and other biomedical applications.

  • 63.
    Wu, Xiaowei
    et al.
    Queen's University, Department of Chemistry, Kingston, ON, Kanada.
    Blackburn, Thomas
    Queen's University, Department of Chemistry, Kingston, ON, Kanada.
    Webb, Jonathan D.
    Queen's University, Department of Chemistry, Kingston, ON, Kanada.
    Garcia-Bennett, Alfonso E.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Crudden, Cathleen M.
    Queen's University, Department of Chemistry, Kingston, ON, Kanada.
    The Synthesis of Chiral Periodic Organosilica Materials with Ultrasmall Mesopores2011Inngår i: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 50, nr 35, s. 8095-8099Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Helical organosilica materials were synthesized for the first time using a novel binaphthyl-based chiral co-monomer in less than 1 hour. The incorporation of a chiral co-monomer in the wall was shown to influence the curvature of the helical materials. As the amount of the chiral co-monomer was increased, the degree of curvature increased, illustrating the importance of this monomer to the overall morphology.

  • 64.
    Xia, Xin
    et al.
    Nanologica AB, Stockholm, och Dept of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University.
    Zhou, Chunfang
    Nanologica AB, Stockholm.
    Ballell, Luís
    Diseases of the Developing World, GlaxoSmithKline, Madrid, Spanien.
    Garcia-Bennett, Alfonso E
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    In vivo Enhancement in Bioavailability of Atazanavir in the Presence of Proton-Pump Inhibitors using Mesoporous Materials2012Inngår i: ChemMedChem, ISSN 1860-7179, E-ISSN 1860-7187, Vol. 7, nr 1, s. 43-8Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Matters of the HAART! The current treatment for human immunodeficiency virus (HIV), HAART, makes use of a combination of antiretroviral drugs, which are poorly soluble in aqueous media. Enhancing the solubility of such drugs through the use of mesoporous materials could lead to improved treatment efficiency and might provide a solution to the drug-drug interaction problems associated with these types of therapeutic regimes.

  • 65. Zhou, C. F.
    et al.
    Garcia-Bennett, Alfonso
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Nanostructured mesoporous materials in drug delivery2010Konferansepaper (Fagfellevurdert)
  • 66. Zhou, Chunfang
    et al.
    Garcia-Bennett, Alfonso E.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Release of folate and derivatives from Folic Acid Materials (NFM-1)2009Konferansepaper (Fagfellevurdert)
  • 67. Zhou, Chunfang
    et al.
    Garcia-Bennett, Alfonso E
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Release of folic acid in mesoporous NFM-1 silica.2010Inngår i: Journal of Nanoscience and Nanotechnology, ISSN 1533-4880, E-ISSN 1533-4899, Vol. 10, nr 11, s. 7398-401Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Mesoporous NFM-1 silica with folic acid as template was prepared taking advantage of the supramolecular self-assembly of pterin groups and their abilities to form hexagonal liquid crystal phases. NFM-1 materials with the varied morphologies such as fiber, chiral twisting long-rod, gyroid, and amorphous particles were prepared by varying the amount of the co-structure directing agent, stirring speed and changing pH value of the synthesis. The release kinetics of NFM-1 samples with different morphologies were studied in phosphate buffer with pH = 7.4 in 37 degrees C under stirring. All the release kinetic curves are fitted by the power law and Higuchi equations. The fitting of the power law equation was separately done as for the released amount up to 60% or 100%. The materials show slow, long-term and sustained release of folic acid from mesoporous NFM-1 silica, which establishes a new foundation for the potential application in drug delivery and bioimaging.

  • 68.
    Zhou, Chunfang
    et al.
    Nanologica AB, Stockholm.
    Kunzmann, Andrea
    Division of Molecular Toxicology, Institute of Environmental Medicine, KI, Stockholm.
    Rakonjac, Marija
    Division of Molecular Toxicology, Institute of Environmental Medicine, KI, Stockholm.
    Fadeel, Bengt
    Division of Molecular Toxicology, Institute of Environmental Medicine, KI, Stockholm.
    Garcia-Bennett, Alfonso
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Morphological properties of nanoporous folic acid materials and in vitro assessment of their biocompatibility2012Inngår i: Nanomedicine, ISSN 1743-5889, E-ISSN 1748-6963, Vol. 7, nr 3, s. 327-334Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Mesoporous silica-based particles are of potential interest for the development of novel therapeutic targeted delivery vehicles. Their ability to load and release large quantities of active pharmaceutical products with varying properties, combining controlled and targeted release functions make them unique amongst nanotechnology-based carrier systems.

    Materials & methods: In this study, nanoporous folic acid-templated materials (NFM-1) were prepared and the synthetic strategies for the control of textural and morphology properties of NFM-1 are described. The potential biocompatibility of NFM-1 particles with different morphology (gyroid shaped, fibers and rod-shaped) was assessed using a panel of human cell lines.

    Results: The results reveal that NFM-1 morphology has an impact on cell viability such that particles showing higher aspect ratios possess increased cytotoxicity.

    Conclusion: These studies provide useful information for the development of novel mesoporous materials for biomedical applications, including cell-specific drug delivery.

12 51 - 68 of 68
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