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  • 51.
    Aartsen, M. G.
    et al.
    Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia..
    Abraham, K.
    Tech Univ Munich, D-85748 Garching, Germany..
    Ackermann, M.
    DESY, D-15735 Zeuthen, Germany..
    Adams, J.
    Univ Canterbury, Dept Phys & Astron, Private Bag 4800, Christchurch 1, New Zealand.;Sungkyunkwan Univ, Dept Phys, Suwon 440746, South Korea. Univ Toronto, Dept Phys, 60 St George St, Toronto, ON M5S 1A7, Canada..
    Aguilar, J. A.
    Univ Libre Bruxelles, Fac Sci, CP230, B-1050 Brussels, Belgium..
    Ahlers, M.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Ahrens, M.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Altmann, D.
    Univ Erlangen Nurnberg, Erlangen Ctr Astroparticle Phys, D-91058 Erlangen, Germany..
    Anderson, T.
    Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA..
    Archinger, M.
    Johannes Gutenberg Univ Mainz, Inst Phys, Staudinger Weg 7, D-55099 Mainz, Germany..
    Argueelles, C.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Arlen, T. C.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Auffenberg, J.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Bai, X.
    South Dakota Sch Mines & Technol, Dept Phys, Rapid City, SD 57701 USA..
    Barwick, S. W.
    Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA..
    Baum, V.
    Johannes Gutenberg Univ Mainz, Inst Phys, Staudinger Weg 7, D-55099 Mainz, Germany..
    Bay, R.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA..
    Beatty, J. J.
    Ohio State Univ, Dept Phys, Columbus, OH 43210 USA.;Ohio State Univ, Ctr Cosmol & Astroparticle Phys, Columbus, OH 43210 USA.;Ohio State Univ, Dept Astron, 174 W 18Th Ave, Columbus, OH 43210 USA..
    Tjus, J. Becker
    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Becker, K. -H
    Beiser, E.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    BenZvi, S.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Berghaus, P.
    DESY, D-15735 Zeuthen, Germany..
    Berley, D.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Bernardini, E.
    DESY, D-15735 Zeuthen, Germany..
    Bernhard, A.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Tech Univ Munich, D-85748 Garching, Germany.;Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Besson, D. Z.
    Univ Kansas, Dept Phys & Astron, Lawrence, KS 66045 USA..
    Binder, G.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Bindig, D.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Bissok, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Blaufuss, E.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Blumenthal, J.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Boersma, David J.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk strålningsvetenskap.
    Bohm, C.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Boerner, M.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Bos, F.
    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Bose, D.
    Boeser, S.
    Johannes Gutenberg Univ Mainz, Inst Phys, Staudinger Weg 7, D-55099 Mainz, Germany..
    Botner, Olga
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Braun, J.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Brayeur, L.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Bretz, H. -P
    Brown, A. M.
    Univ Canterbury, Dept Phys & Astron, Private Bag 4800, Christchurch 1, New Zealand.;Sungkyunkwan Univ, Dept Phys, Suwon 440746, South Korea. Univ Toronto, Dept Phys, 60 St George St, Toronto, ON M5S 1A7, Canada..
    Buzinsky, N.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Casey, J.
    Georgia Inst Technol, Sch Phys, Atlanta, GA 30332 USA.;Georgia Inst Technol, Ctr Relativist Astrophys, Atlanta, GA 30332 USA..
    Casier, M.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Cheung, E.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Chirkin, D.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Christov, A.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA.;Univ Maryland, Dept Phys, College Pk, MD 20742 USA.;TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany.;Univ Geneva, Dept Phys Nucl & Corpusculaire, CH-1211 Geneva, Switzerland.;Univ Wisconsin, Dept Phys, Madison, WI 53706 USA..
    Christy, B.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Clark, K.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Classen, L.
    Univ Erlangen Nurnberg, Erlangen Ctr Astroparticle Phys, D-91058 Erlangen, Germany..
    Coenders, S.
    Tech Univ Munich, D-85748 Garching, Germany..
    Cowen, D. F.
    Penn State Univ, Dept Astron & Astrophys, 525 Davey Lab, University Pk, PA 16802 USA.;Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA..
    Silva, A. H. Cruz
    DESY, D-15735 Zeuthen, Germany..
    Daughhetee, J.
    Georgia Inst Technol, Sch Phys, Atlanta, GA 30332 USA.;Georgia Inst Technol, Ctr Relativist Astrophys, Atlanta, GA 30332 USA..
    Davis, J. C.
    Ohio State Univ, Dept Phys, Columbus, OH 43210 USA.;Ohio State Univ, Ctr Cosmol & Astroparticle Phys, Columbus, OH 43210 USA..
    Day, M.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    de Andre, J. P. A. M.
    Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA..
    De Clercq, C.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Dembinski, H.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    De Ridder, S.
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Desiati, P.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    de Vries, K. D.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    de Wasseige, G.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    de With, M.
    Humboldt Univ, Inst Phys, D-12489 Berlin, Germany..
    DeYoung, T.
    Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA..
    Diaz-Velez, J. C.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Dumm, J. P.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Dunkman, M.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Eagans, R.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Eberhardt, B.
    Johannes Gutenberg Univ Mainz, Inst Phys, Staudinger Weg 7, D-55099 Mainz, Germany..
    Ehrhardt, T.
    Johannes Gutenberg Univ Mainz, Inst Phys, Staudinger Weg 7, D-55099 Mainz, Germany..
    Eichmann, B.
    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Euler, Sebastian
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Evenson, P. A.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Fadiran, O.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Fahey, S.
    Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Fazely, A. R.
    Southern Univ, Dept Phys, Baton Rouge, LA 70813 USA..
    Fedynitch, A.
    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Feintzeig, J.
    Univ Alaska Anchorage, Dept Phys & Astron, 3211 Providence Dr, Anchorage, AK 99508 USA..
    Felde, J.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Filimonov, K.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA..
    Finley, C.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Fischer-Wasels, T.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Flis, S.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Fuchs, T.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Glagla, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Gaisser, T. K.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Gaior, R.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
    Gallagher, J.
    Univ Wisconsin, Dept Astron, Madison, WI 53706 USA..
    Gerhardth, L.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Ghorbani, K.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Gier, D.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Gladstone, L.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Gliisenkamp, T.
    DESY, D-15735 Zeuthen, Germany..
    Goldschmidt, A.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Golup, G.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Gonzalez, J. G.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Gora, D.
    DESY, D-15735 Zeuthen, Germany..
    Grant, D.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Gretskov, P.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Groh, J. C.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Gross, A.
    Tech Univ Munich, D-85748 Garching, Germany..
    Ha, C.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Haack, C.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Ismail, A. Haj
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Hallgren, Allan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Halzen, F.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Hansmann, B.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Hanson, K.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Hebecker, D.
    Humboldt Univ, Inst Phys, D-12489 Berlin, Germany..
    Heereman, D.
    Univ Oxford, Dept Phys, 1 Keble Rd, Oxford OX1 3NP, England..
    Helbing, K.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Hellauer, R.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Hellwig, D.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Hickford, S.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Hignight, J.
    Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA..
    Hill, G. C.
    Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia..
    Hoffman, K. D.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Hoffmann, R.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Holzapfel, K.
    Tech Univ Munich, D-85748 Garching, Germany..
    Homeier, A.
    Univ Bonn, Inst Phys, Nussallee 12, D-53115 Bonn, Germany..
    Hoshina, K.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA.;Univ Tokyo, Earthquake Res Inst, Tokyo 1130032, Japan..
    Huang, F.
    Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA..
    Huber, M.
    Tech Univ Munich, D-85748 Garching, Germany..
    Huelsnitz, W.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Hulth, P. O.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Hultqvist, K.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    In, S.
    Ishihara, A.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
    Jacobi, E.
    DESY, D-15735 Zeuthen, Germany..
    Japaridze, G. S.
    Clark Atlanta Univ, CTSPS, Atlanta, GA 30314 USA..
    Jero, K.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Jurkovic, M.
    Tech Univ Munich, D-85748 Garching, Germany..
    Kaminsky, B.
    DESY, D-15735 Zeuthen, Germany..
    Kappes, A.
    Univ Erlangen Nurnberg, Erlangen Ctr Astroparticle Phys, D-91058 Erlangen, Germany..
    Karg, T.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Karle, A.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Kauer, M.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA.;Yale Univ, Dept Phys, New Haven, CT 06520 USA..
    Keivani, A.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA..
    Kelley, J. L.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Kemp, J.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Kheirandish, A.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Kiryluk, J.
    SUNY Stony Brook, Dept Phys & Astron, Stony Brook, NY 11794 USA..
    Klas, J.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Klein, S. R.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Kohnen, G.
    Univ Mons, B-7000 Mons, Belgium..
    Koirala, R.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Kolanoski, H.
    Humboldt Univ, Inst Phys, D-12489 Berlin, Germany..
    Konietz, R.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Koob, A.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Kopke, L.
    Johannes Gutenberg Univ Mainz, Inst Phys, Staudinger Weg 7, D-55099 Mainz, Germany..
    Kopper, C.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Kopper, S.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Koskinen, D. J.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Kowalski, M.
    Humboldt Univ, Inst Phys, D-12489 Berlin, Germany.;DESY, D-15735 Zeuthen, Germany..
    Krings, K.
    Tech Univ Munich, D-85748 Garching, Germany..
    Kroll, G.
    Johannes Gutenberg Univ Mainz, Inst Phys, Staudinger Weg 7, D-55099 Mainz, Germany..
    Kroll, M.
    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Kunnen, J.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Kurahashi, N.
    Drexel Univ, Dept Phys, 3141 Chestnut St, Philadelphia, PA 19104 USA..
    Kuwabara, T.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
    Labare, M.
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Lanfranchi, J. L.
    Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA..
    Larson, M. J.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Lesiak-Bzdak, M.
    SUNY Stony Brook, Dept Phys & Astron, Stony Brook, NY 11794 USA..
    Leuermann, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Leuner, J.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Lunemann, J.
    Johannes Gutenberg Univ Mainz, Inst Phys, Staudinger Weg 7, D-55099 Mainz, Germany..
    Madsen, J.
    Univ Wisconsin, Dept Phys, River Falls, WI 54022 USA..
    Maggi, G.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Mahn, K. B. M.
    Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA..
    Maruyama, R.
    Yale Univ, Dept Phys, New Haven, CT 06520 USA..
    Mase, K.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
    Matis, H. S.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Maunu, R.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    McNally, F.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Meagher, K.
    Univ Libre Bruxelles, Fac Sci, CP230, B-1050 Brussels, Belgium..
    Medici, M.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Meli, A.
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Menne, T.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Merino, G.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Meures, T.
    Univ Libre Bruxelles, Fac Sci, CP230, B-1050 Brussels, Belgium..
    Miarecki, S.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Middell, E.
    DESY, D-15735 Zeuthen, Germany..
    Middlemas, E.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Miller, J.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Mohrmann, L.
    DESY, D-15735 Zeuthen, Germany..
    Montaruli, T.
    Univ Geneva, Dept Phys Nucl & Corpusculaire, CH-1211 Geneva, Switzerland..
    Morse, R.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Nahnhauer, R.
    DESY, D-15735 Zeuthen, Germany..
    Naumann, U.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Niederhausen, H.
    SUNY Stony Brook, Dept Phys & Astron, Stony Brook, NY 11794 USA..
    Nowicki, S. C.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Nygren, D. R.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Obertacke, A.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Olivas, A.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Omairat, A.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    O'Murchadha, A.
    Univ Libre Bruxelles, Fac Sci, CP230, B-1050 Brussels, Belgium..
    Palczewski, T.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    Pandya, H.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Paul, L.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Pepper, J. A.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    Perez de los Heros, Carlos
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Pfendner, C.
    Ohio State Univ, Dept Phys, Columbus, OH 43210 USA.;Ohio State Univ, Ctr Cosmol & Astroparticle Phys, Columbus, OH 43210 USA..
    Pieloth, D.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Pinat, E.
    Univ Libre Bruxelles, Fac Sci, CP230, B-1050 Brussels, Belgium..
    Posselt, J.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Price, P. B.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA..
    Przybylski, G. T.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Putz, J.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Quinnan, M.
    Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA..
    Radel, L.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Rameez, M.
    Univ Geneva, Dept Phys Nucl & Corpusculaire, CH-1211 Geneva, Switzerland..
    Rawlins, K.
    Univ Alaska Anchorage, Dept Phys & Astron, 3211 Providence Dr, Anchorage, AK 99508 USA..
    Redl, P.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Reimann, R.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Relich, M.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
    Resconi, E.
    Tech Univ Munich, D-85748 Garching, Germany..
    Rhode, W.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Richman, M.
    Drexel Univ, Dept Phys, 3141 Chestnut St, Philadelphia, PA 19104 USA..
    Richter, S.
    Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Riedel, B.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Robertson, S.
    Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia..
    Rongen, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Rott, C.
    Ruhe, T.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Ryckbosch, D.
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Saba, S. M.
    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Sabbatini, L.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Sander, H. -G
    Sandrock, A.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Sandroos, J.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Sarkar, S.
    Univ Libre Bruxelles, Fac Sci, CP230, B-1050 Brussels, Belgium.;Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Schatto, K.
    Johannes Gutenberg Univ Mainz, Inst Phys, Staudinger Weg 7, D-55099 Mainz, Germany..
    Scheriau, F.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Schimp, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Schmidt, T.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Schmitz, M.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Schoenen, S.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Schoneberg, S.
    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Schonwald, A.
    DESY, D-15735 Zeuthen, Germany..
    Schukraft, A.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Schulte, L.
    Univ Bonn, Inst Phys, Nussallee 12, D-53115 Bonn, Germany..
    Seckel, D.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Seunarine, S.
    Univ Wisconsin, Dept Phys, River Falls, WI 54022 USA..
    Shanidze, R.
    DESY, D-15735 Zeuthen, Germany..
    Smith, M. W. E.
    Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA..
    Soldin, D.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Spiczak, G. M.
    Univ Wisconsin, Dept Phys, River Falls, WI 54022 USA..
    Spiering, C.
    DESY, D-15735 Zeuthen, Germany..
    Stahlberg, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Stamatikos, M.
    Ohio State Univ, Dept Phys, Columbus, OH 43210 USA.;Ohio State Univ, Ctr Cosmol & Astroparticle Phys, Columbus, OH 43210 USA.;NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA..
    Stanev, T.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Stanisha, N. A.
    Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA..
    Stasik, A.
    DESY, D-15735 Zeuthen, Germany..
    Stezelberger, T.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Stokstad, R. G.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Stossl, A.
    DESY, D-15735 Zeuthen, Germany..
    Strahler, E. A.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Ström, Rickard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Strotjohann, N. L.
    DESY, D-15735 Zeuthen, Germany..
    Sullivan, G. W.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Sutherland, M.
    Ohio State Univ, Dept Phys, Columbus, OH 43210 USA.;Ohio State Univ, Ctr Cosmol & Astroparticle Phys, Columbus, OH 43210 USA..
    Taavola, Henric
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Taboada, I.
    Georgia Inst Technol, Sch Phys, Atlanta, GA 30332 USA.;Georgia Inst Technol, Ctr Relativist Astrophys, Atlanta, GA 30332 USA..
    Ter-Antonyan, S.
    Southern Univ, Dept Phys, Baton Rouge, LA 70813 USA..
    Terliuk, A.
    DESY, D-15735 Zeuthen, Germany..
    Tesic, G.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Tilav, S.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Toale, P. A.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    Tobin, M. N.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Tosi, D.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Tselengidou, M.
    Univ Erlangen Nurnberg, Erlangen Ctr Astroparticle Phys, D-91058 Erlangen, Germany..
    Turcati, A.
    Tech Univ Munich, D-85748 Garching, Germany..
    Unger, Lisa E.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik. Uppsala Univ, Dept Phys & Astron, Box 516, S-75120 Uppsala, Sweden..
    Usner, M.
    DESY, D-15735 Zeuthen, Germany..
    Vallecorsa, S.
    Univ Geneva, Dept Phys Nucl & Corpusculaire, CH-1211 Geneva, Switzerland..
    van Eijndhoven, N.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Vandenbroucke, J.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    van Santen, J.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Vanheule, S.
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Veenkamp, J.
    Tech Univ Munich, D-85748 Garching, Germany..
    Vehring, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Voge, M.
    Univ Bonn, Inst Phys, Nussallee 12, D-53115 Bonn, Germany..
    Vraeghe, M.
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Walck, C.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Wallraff, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Wandkowsky, N.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Weaver, Ch
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Wendt, C.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Westerhoff, S.
    Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Whelan, B. J.
    Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia..
    Whitehorn, N.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Wichary, C.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Wiebe, K.
    Johannes Gutenberg Univ Mainz, Inst Phys, Staudinger Weg 7, D-55099 Mainz, Germany..
    Wiebusch, C. H.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Wille, L.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Williams, D. R.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    Wissing, H.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Wolf, M.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Wood, T. R.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Woschnagg, K.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA..
    Xu, D. L.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    Xu, X. W.
    Southern Univ, Dept Phys, Baton Rouge, LA 70813 USA..
    Xun, Y.
    SUNY Stony Brook, Dept Phys & Astron, Stony Brook, NY 11794 USA..
    Yanez, J. P.
    DESY, D-15735 Zeuthen, Germany..
    Yodh, G.
    Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA..
    Yoshida, S.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
    Zarzhitsky, P.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    Zoll, M.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Characterization of the atmospheric muon flux in IceCube2016Ingår i: Astroparticle physics, ISSN 0927-6505, E-ISSN 1873-2852, Vol. 78, s. 1-27Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Muons produced in atmospheric cosmic ray showers account for the by far dominant part of the event yield in large-volume underground particle detectors. The IceCube detector, with an instrumented volume of about a cubic kilometer, has the potential to conduct unique investigations on atmospheric muons by exploiting the large collection area and the possibility to track particles over a long distance. Through detailed reconstruction of energy deposition along the tracks, the characteristics of muon bundles can be quantified, and individual particles of exceptionally high energy identified. The data can then be used to constrain the cosmic ray primary flux and the contribution to atmospheric lepton fluxes from prompt decays of short-lived hadrons. In this paper, techniques for the extraction of physical measurements from atmospheric muon events are described and first results are presented. The multiplicity spectrum of TeV muons in cosmic ray air showers for primaries in the energy range from the knee to the ankle is derived and found to be consistent with recent results from surface detectors. The single muon energy spectrum is determined up to PeV energies and shows a clear indication for the emergence of a distinct spectral component from prompt decays of short-lived hadrons. The magnitude of the prompt flux, which should include a substantial contribution from light vector meson di-muon decays, is consistent with current theoretical predictions. The variety of measurements and high event statistics can also be exploited for the evaluation of systematic effects. In the course of this study, internal inconsistencies in the zenith angle distribution of events were found which indicate the presence of an unexplained effect outside the currently applied range of detector systematics. The underlying cause could be related to the hadronic interaction models used to describe muon production in air showers.

  • 52.
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    Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia..
    Abraham, K.
    Tech Univ Munich, D-85748 Garching, Germany..
    Ackermann, M.
    DESY, D-15735 Zeuthen, Germany..
    Adams, J.
    Univ Canterbury, Dept Phys & Astron, Christchurch 1, New Zealand..
    Aguilar, J. A.
    Univ Libre Bruxelles, Fac Sci, B-1050 Brussels, Belgium..
    Ahlers, M.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Ahrens, M.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Altmann, D.
    Univ Erlangen Nurnberg, Erlangen Ctr Astroparticle Phys, D-91058 Erlangen, Germany..
    Anderson, T.
    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
    Archinger, M.
    Johannes Gutenberg Univ Mainz, Inst Phys, D-55099 Mainz, Germany..
    Arguelles, C.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Arlen, T. C.
    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
    Auffenberg, J.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Bai, X.
    South Dakota Sch Mines & Technol, Dept Phys, Rapid City, SD 57701 USA..
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    Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA..
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    Johannes Gutenberg Univ Mainz, Inst Phys, D-55099 Mainz, Germany..
    Bay, R.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA..
    Beatty, J. J.
    Ohio State Univ, Dept Phys, Columbus, OH 43210 USA.;Ohio State Univ, Ctr Cosmol & Astroparticle, Columbus, OH 43210 USA.;Ohio State Univ, Dept Astron, Columbus, OH 43210 USA..
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    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Becker, K. -H
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    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
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    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
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    DESY, D-15735 Zeuthen, Germany..
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    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
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    DESY, D-15735 Zeuthen, Germany..
    Bernhard, A.
    Tech Univ Munich, D-85748 Garching, Germany..
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    Univ Kansas, Dept Phys & Astron, Lawrence, KS 66045 USA..
    Binder, G.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
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    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
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    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
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    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
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    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Boersma, David. J.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk strålningsvetenskap. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik. Uppsala Univ, Dept Phys & Astron, SE-75120 Uppsala, Sweden..
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    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
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    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
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    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
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    Sungkyunkwan Univ, Dept Phys, Suwon 440746, South Korea..
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    Johannes Gutenberg Univ Mainz, Inst Phys, D-55099 Mainz, Germany..
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    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
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    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Brayeur, L.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Bretz, H. -P
    Brown, A. M.
    Univ Canterbury, Dept Phys & Astron, Christchurch 1, New Zealand..
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    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
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    Georgia Inst Technol, Sch Phys, Atlanta, GA 30332 USA.;Georgia Inst Technol, Ctr Relativist Astrophys, Atlanta, GA 30332 USA..
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    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Cheung, E.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Chirkin, D.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
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    Univ Geneva, Dept Phys Nucl & Corpusculaire, CH-1211 Geneva, Switzerland..
    Christy, B.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
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    Univ Toronto, Dept Phys, Toronto, ON M5S 1A7, Canada..
    Classen, L.
    Univ Erlangen Nurnberg, Erlangen Ctr Astroparticle Phys, D-91058 Erlangen, Germany..
    Coenders, S.
    Tech Univ Munich, D-85748 Garching, Germany..
    Cowen, D. F.
    Penn State Univ, Dept Phys, University Pk, PA 16802 USA.;Penn State Univ, Dept Astron & Astrophys, University Pk, PA 16802 USA..
    Silva, A. H. Cruz
    DESY, D-15735 Zeuthen, Germany..
    Daughhetee, J.
    Georgia Inst Technol, Sch Phys, Atlanta, GA 30332 USA.;Georgia Inst Technol, Ctr Relativist Astrophys, Atlanta, GA 30332 USA..
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    Ohio State Univ, Dept Phys, Columbus, OH 43210 USA.;Ohio State Univ, Ctr Cosmol & Astroparticle, Columbus, OH 43210 USA..
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    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
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    Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA..
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    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
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    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
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    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
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    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
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    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
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    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
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    Humboldt Univ, Inst Phys, D-12489 Berlin, Germany..
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    Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA..
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    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
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    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
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    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
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    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
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    Johannes Gutenberg Univ Mainz, Inst Phys, D-55099 Mainz, Germany..
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    Johannes Gutenberg Univ Mainz, Inst Phys, D-55099 Mainz, Germany..
    Eichmann, B.
    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Euler, Sebastian
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
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    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
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    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
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    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
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    Southern Univ, DeVment Phys, Baton Rouge, LA 70813 USA..
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    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
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    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
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    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
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    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA..
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    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
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    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
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    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
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    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
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    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
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    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Gator, R.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
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    Univ Wisconsin, Dept Astron, Madison, WI 53706 USA..
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    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
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    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Gier, D.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Gladstone, L.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Gluesenkamp, T.
    DESY, D-15735 Zeuthen, Germany..
    Goldschmidt, A.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Golup, G.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Gonzalez, J. G.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Gora, D.
    DESY, D-15735 Zeuthen, Germany..
    Grant, D.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Gretskov, P.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Groh, J. C.
    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
    Gross, A.
    Tech Univ Munich, D-85748 Garching, Germany..
    Ha, C.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Haack, C.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Ismail, A. Haj
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Hallgren, Allan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik. Uppsala Univ, Dept Phys & Astron, SE-75120 Uppsala, Sweden..
    Halzen, F.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Hansmann, B.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Hanson, K.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Hebecker, D.
    Humboldt Univ, Inst Phys, D-12489 Berlin, Germany..
    Heereman, D.
    Univ Libre Bruxelles, Fac Sci, B-1050 Brussels, Belgium..
    Helbing, K.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Hellauer, R.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Hellwig, D.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Hickford, S.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Hignight, J.
    Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA..
    Hill, G. C.
    Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia..
    Hoffman, K. D.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Hoffmann, R.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Holzapfe, K.
    Tech Univ Munich, D-85748 Garching, Germany..
    Homeier, A.
    Univ Bonn, Inst Phys, D-53115 Bonn, Germany..
    Hoshina, K.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA.;Univ Tokyo, Earthquake Res Inst, Bunkyo Ku, Tokyo 1130032, Japan..
    Huang, F.
    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
    Huber, M.
    Tech Univ Munich, D-85748 Garching, Germany..
    Huelsnitz, W.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Hulth, P. O.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Hultqvist, K.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    In, S.
    Sungkyunkwan Univ, Dept Phys, Suwon 440746, South Korea..
    Ishihara, A.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
    Jacobi, E.
    DESY, D-15735 Zeuthen, Germany..
    Japaridze, G. S.
    Clark Atlanta Univ, CTSPS, Atlanta, GA 30314 USA..
    Jero, K.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Jurkovic, M.
    Tech Univ Munich, D-85748 Garching, Germany..
    Kaminsky, B.
    DESY, D-15735 Zeuthen, Germany..
    Kappes, A.
    Univ Erlangen Nurnberg, Erlangen Ctr Astroparticle Phys, D-91058 Erlangen, Germany..
    Karg, T.
    DESY, D-15735 Zeuthen, Germany..
    Karle, A.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Kauer, M.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA.;Yale Univ, Dept Phys, New Haven, CT 06520 USA..
    Keivani, A.
    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
    Kelley, J. L.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Kemp, J.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Kheirandish, A.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Kiryluk, J.
    SUNY Stony Brook, Dept Phys & Astron, Stony Brook, NY 11794 USA..
    Klaes, J.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Klein, S. R.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Kohnen, G.
    Univ Mons, B-7000 Mons, Belgium..
    Koirala, R.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Kolanoski, H.
    Humboldt Univ, Inst Phys, D-12489 Berlin, Germany..
    Konietz, R.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Koob, A.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Koepke, L.
    Johannes Gutenberg Univ Mainz, Inst Phys, D-55099 Mainz, Germany..
    Kopper, C.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Kopper, S.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Koskinen, D. J.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Kowalski, M.
    DESY, D-15735 Zeuthen, Germany.;Humboldt Univ, Inst Phys, D-12489 Berlin, Germany..
    Krings, K.
    Tech Univ Munich, D-85748 Garching, Germany..
    Kroll, G.
    Johannes Gutenberg Univ Mainz, Inst Phys, D-55099 Mainz, Germany..
    Kroll, M.
    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Kunnen, J.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Kurahashi, N.
    Drexel Univ, Dept Phys, Philadelphia, PA 19104 USA..
    Kuwabara, T.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
    Labare, M.
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Lanfranchi, J. L.
    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
    Larson, M. J.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Lesiak-Bzdak, M.
    SUNY Stony Brook, Dept Phys & Astron, Stony Brook, NY 11794 USA..
    Leuermann, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Leuner, J.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Luenemann, J.
    Johannes Gutenberg Univ Mainz, Inst Phys, D-55099 Mainz, Germany..
    Madsen, J.
    Univ Wisconsin, Dept Phys, River Falls, WI 54022 USA..
    Maggi, G.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Mahn, K. B. M.
    Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA..
    Maruyama, R.
    Yale Univ, Dept Phys, New Haven, CT 06520 USA..
    Mase, K.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
    Matis, H. S.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Maunu, R.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    McNally, F.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Meagher, K.
    Univ Libre Bruxelles, Fac Sci, B-1050 Brussels, Belgium..
    Medici, M.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Meli, A.
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Menne, T.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Merino, G.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Meures, T.
    Univ Libre Bruxelles, Fac Sci, B-1050 Brussels, Belgium..
    Miarecki, S.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Middell, E.
    DESY, D-15735 Zeuthen, Germany..
    Middlemas, E.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Miller, J.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Mohrmann, L.
    DESY, D-15735 Zeuthen, Germany..
    Montaruli, T.
    Univ Geneva, Dept Phys Nucl & Corpusculaire, CH-1211 Geneva, Switzerland..
    Morse, R.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Nahnhauer, R.
    DESY, D-15735 Zeuthen, Germany..
    Naumann, U.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Niederhausen, H.
    SUNY Stony Brook, Dept Phys & Astron, Stony Brook, NY 11794 USA..
    Nowicki, S. C.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Nygre, D. R.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Obertacke, A.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Olivas, A.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Omairat, A.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    O'Murchadha, A.
    Univ Libre Bruxelles, Fac Sci, B-1050 Brussels, Belgium..
    Palczewski, T.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    Pandya, H.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Paul, L.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Pepper, J. A.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    de los Heros, Carlos Perez
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Pfendner, C.
    Ohio State Univ, Dept Phys, Columbus, OH 43210 USA.;Ohio State Univ, Ctr Cosmol & Astroparticle, Columbus, OH 43210 USA..
    Pieloth, D.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Pinat, E.
    Univ Libre Bruxelles, Fac Sci, B-1050 Brussels, Belgium..
    Posselt, J.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Price, P. B.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA..
    Przybylski, G. T.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Puetz, J.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Quinnan, M.
    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
    Raedel, L.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Rameez, M.
    Univ Geneva, Dept Phys Nucl & Corpusculaire, CH-1211 Geneva, Switzerland..
    Rawlins, K.
    Univ Alaska Anchorage, Dept Phys & Astron, Anchorage, AK 99508 USA..
    Redl, P.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Reimann, R.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Relich, M.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
    Resconi, E.
    Tech Univ Munich, D-85748 Garching, Germany..
    Rhode, W.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Richman, M.
    Drexel Univ, Dept Phys, Philadelphia, PA 19104 USA..
    Richter, S.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Riedel, B.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Robertson, S.
    Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia..
    Rongen, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Rott, C.
    Sungkyunkwan Univ, Dept Phys, Suwon 440746, South Korea..
    Ruhe, T.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Ryckbosch, D.
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Saba, S. M.
    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Sabbatini, L.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Sander, H. -G
    Sandrock, A.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Sandroos, J.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark..
    Sarkar, S.
    Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark.;Univ Oxford, Dept Phys, Oxford OX1 3NP, England..
    Schatto, K.
    Johannes Gutenberg Univ Mainz, Inst Phys, D-55099 Mainz, Germany..
    Scheriau, F.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Schimp, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Schmidt, T.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Schmitz, M.
    TU Dortmund Univ, Dept Phys, D-44221 Dortmund, Germany..
    Schoenen, S.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Schoeneberg, S.
    Ruhr Univ Bochum, Fak Phys & Astron, D-44780 Bochum, Germany..
    Schoenwald, A.
    DESY, D-15735 Zeuthen, Germany..
    Schukraft, A.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Schulte, L.
    Univ Bonn, Inst Phys, D-53115 Bonn, Germany..
    Seckel, D.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Seunarine, S.
    Univ Wisconsin, Dept Phys, River Falls, WI 54022 USA..
    Shanidze, R.
    DESY, D-15735 Zeuthen, Germany..
    Smith, M. W. E.
    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
    Soldin, D.
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany..
    Spiczak, G. M.
    Univ Wisconsin, Dept Phys, River Falls, WI 54022 USA..
    Ering, C.
    DESY, D-15735 Zeuthen, Germany..
    Stahlberg, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Stamatikos, M.
    Ohio State Univ, Dept Phys, Columbus, OH 43210 USA.;Ohio State Univ, Ctr Cosmol & Astroparticle, Columbus, OH 43210 USA.;NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA..
    Stanev, T.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Stanisha, N. A.
    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
    Stasik, A.
    DESY, D-15735 Zeuthen, Germany..
    Stezelberger, T.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Stokstad, R. G.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA..
    Stoessl, A.
    DESY, D-15735 Zeuthen, Germany..
    Strahlers, E. A.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Ström, Rickard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Strotjohann, N. L.
    DESY, D-15735 Zeuthen, Germany..
    Suwvan, G. W.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Sutherland, M.
    Ohio State Univ, Dept Phys, Columbus, OH 43210 USA.;Ohio State Univ, Ctr Cosmol & Astroparticle, Columbus, OH 43210 USA..
    Taavola, Henric
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Taboada, I.
    Ter-Antonyan, S.
    Southern Univ, DeVment Phys, Baton Rouge, LA 70813 USA..
    Terliuk, A.
    DESY, D-15735 Zeuthen, Germany..
    Tesic, G.
    Penn State Univ, Dept Phys, University Pk, PA 16802 USA..
    Tilav, S.
    Univ Delaware, Bartol Res Inst, Newark, DE 19716 USA.;Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA..
    Toale, P. A.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    Tobin, M. N.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Tosi, D.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Tselengidou, M.
    Univ Erlangen Nurnberg, Erlangen Ctr Astroparticle Phys, D-91058 Erlangen, Germany..
    Turcati, A.
    Tech Univ Munich, D-85748 Garching, Germany..
    Unger, Elisabeth
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Usner, M.
    DESY, D-15735 Zeuthen, Germany..
    Vallecorsa, S.
    Univ Geneva, Dept Phys Nucl & Corpusculaire, CH-1211 Geneva, Switzerland..
    van Eundhoven, N.
    Vrije Univ Brussel, Dienst ELEM, B-1050 Brussels, Belgium..
    Vandenbroucke, J.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    van Santen, J.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Vanheule, S.
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Veenkamp, J.
    Tech Univ Munich, D-85748 Garching, Germany..
    Vehring, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Voge, M.
    Univ Bonn, Inst Phys, D-53115 Bonn, Germany..
    Vraeghe, M.
    Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium..
    Walck, C.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Wallraff, M.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Wandkowsky, N.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Weaver, Ch.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Wendt, C.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Westerhoff, S.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Whelan, B. J.
    Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia..
    Whitehorn, N.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Wichary, C.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Wiebe, K.
    Johannes Gutenberg Univ Mainz, Inst Phys, D-55099 Mainz, Germany..
    Wiebusch, C. H.
    Rhein Westfal TH Aachen, Inst Phys 3, D-52056 Aachen, Germany..
    Wille, L.
    Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.;Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA..
    Williams, D. R.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    Wissing, H.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA..
    Wolf, M.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Wood, T. R.
    Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada..
    Woschnagg, K.
    Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA..
    Xu, D. L.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    Xu, X. W.
    Southern Univ, DeVment Phys, Baton Rouge, LA 70813 USA..
    Xu, Y.
    SUNY Stony Brook, Dept Phys & Astron, Stony Brook, NY 11794 USA..
    Yanez, J. P.
    DESY, D-15735 Zeuthen, Germany..
    Yodh, G.
    Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA..
    Yoshida, S.
    Chiba Univ, Dept Phys, Chiba 2638522, Japan..
    Zarzhitsky, P.
    Univ Alabama, Dept Phys & Astron, Tuscaloosa, AL 35487 USA..
    Zoll, M.
    Stockholm Univ, Oskar Klein Ctr, SE-10691 Stockholm, Sweden.;Stockholm Univ, Dept Phys, SE-10691 Stockholm, Sweden..
    Ofek, Eran O.
    Weizmann Inst Sci, Dept Particle Phys & Astrophys, IL-76100 Rehovot, Israel..
    Kasliwal, Mansi M.
    Carnegie Inst Sci, Pasadena, CA 91101 USA..
    Nugent, Peter E.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Dept Astronomy, Berkeley, CA 94720 USA..
    Arcavi, Iair
    Las Cumbres Observ Global Telescope, Santa Barbara, CA 93111 USA.;Univ Calif Santa Barbara, Kavli Inst Theoret Phys, Santa Barbara, CA 93106 USA..
    Bloom, Joshua S.
    Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA.;Univ Calif Berkeley, Dept Astronomy, Berkeley, CA 94720 USA..
    Kulkarni, Shrinivas R.
    CALTECH, Cahill Ctr Astrophys, Pasadena, CA 91125 USA..
    Perley, Daniel A.
    CALTECH, Cahill Ctr Astrophys, Pasadena, CA 91125 USA..
    Barlow, Tom
    CALTECH, Cahill Ctr Astrophys, Pasadena, CA 91125 USA..
    Horesh, Assaf
    Weizmann Inst Sci, Dept Particle Phys & Astrophys, IL-76100 Rehovot, Israel..
    Gal-Yam, Avishay
    Weizmann Inst Sci, Dept Particle Phys & Astrophys, IL-76100 Rehovot, Israel..
    Howell, D. A.
    Weizmann Inst Sci, Dept Particle Phys & Astrophys, IL-76100 Rehovot, Israel.;Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA..
    Dilday, Ben
    North Idaho Coll, Coeur Dalene, ID 83814 USA..
    Evans, Phil A.
    Univ Leicester, Dept Phys & Astron, Leicester LE1 7RH, Leics, England..
    Kennea, Jamie A.
    Penn State Univ, Dept Astron & Astrophys, University Pk, PA 16802 USA..
    Burgett, W. S.
    Univ Hawaii Manoa, Inst Astron, Honolulu, HI 96822 USA..
    Chambers, K. C.
    Univ Hawaii Manoa, Inst Astron, Honolulu, HI 96822 USA..
    Kaiser, N.
    Univ Hawaii Manoa, Inst Astron, Honolulu, HI 96822 USA..
    Waters, C.
    Univ Hawaii Manoa, Inst Astron, Honolulu, HI 96822 USA..
    Flewelling, H.
    Univ Hawaii Manoa, Inst Astron, Honolulu, HI 96822 USA..
    Tonry, J. L.
    Univ Hawaii Manoa, Inst Astron, Honolulu, HI 96822 USA..
    Rest, A.
    Space Telescope Sci Inst, Baltimore, MD 21218 USA..
    Smartt, S. J.
    Queens Univ Belfast, Sch Math & Phys, Astrophys Res Ctr, Belfast BT7 1NN, Antrim, North Ireland..
    The Detection Of A Sn Iin In Optical Follow-Up Observations Of Icecube Neutrino Events2015Ingår i: Astrophysical Journal, ISSN 0004-637X, E-ISSN 1538-4357, Vol. 811, nr 1, artikel-id 52Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The IceCube neutrino observatory pursues a follow-up program selecting interesting neutrino events in real-time and issuing alerts for electromagnetic follow-up observations. In 2012 March, the most significant neutrino alert during the first three years of operation was issued by IceCube. In the follow-up observations performed by the Palomar Transient Factory (PTF), a Type IIn supernova (SN IIn) PTF12csy was found 0.degrees 2 away from the neutrino alert direction, with an error radius of 0.degrees 54. It has a redshift of z = 0.0684, corresponding to a luminosity distance of about 300 Mpc and the Pan-STARRS1 survey shows that its explosion time was at least 158 days (in host galaxy rest frame) before the neutrino alert, so that a causal connection is unlikely. The a posteriori significance of the chance detection of both the neutrinos and the SN at any epoch is 2.2 sigma within IceCube's 2011/12 data acquisition season. Also, a complementary neutrino analysis reveals no long-term signal over the course of one year. Therefore, we consider the SN detection coincidental and the neutrinos uncorrelated to the SN. However, the SN is unusual and interesting by itself: it is luminous and energetic, bearing strong resemblance to the SN IIn 2010jl, and shows signs of interaction of the SN ejecta with a dense circumstellar medium. High-energy neutrino emission is expected in models of diffusive shock acceleration, but at a low, non-detectable level for this specific SN. In this paper, we describe the SN PTF12csy and present both the neutrino and electromagnetic data, as well as their analysis.

  • 53.
    Aarum Hansen, Heidi
    et al.
    Department for Health and Social Studies, Østfold University College, Halden, Norway .
    Björktomta, Siv-Britt
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Sociologiska institutionen.
    Svalastog, Anna Lydia
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Centrum för forsknings- och bioetik. Department for Health and Social Studies, Østfold University College, Halden, Norway .
    Digital society generates new challenges on Child Welfare Services2017Ingår i: Croatian Medical Journal, ISSN 0353-9504, E-ISSN 1332-8166, Vol. 58, nr 1, s. 80-83Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Digital society has created a new situation that challenges the present discourse on public services. Since it is only a recent phenomenon, digital society has not yet been in-cluded in the broader filed of social work education and practice. In the present text, we focus on casework with children. The examples described in the text are taken from Scandinavian experiences and reflect our background and practice in social work with children. However, we dare to say that the situation is more or less the same in the rest of Europe, as illustrated by the presented social work examples and references from wider European context.

  • 54.
    Aase, Karin
    et al.
    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, SE-17176 Stockholm, Sweden.
    Ernkvist, Mira
    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, SE-17176 Stockholm, Sweden.
    Ebarasi, Lwaki
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
    Jakobsson, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för genetik och patologi.
    Majumdar, Arindam
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
    Yi, Chunling
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
    Birot, Olivier
    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, SE-17176 Stockholm, Sweden.
    Ming, Yue
    Department of Clinical Neuroscience, Section of Ophthalmology and Vision, Karolinska Institutet, St Erik’s Hospital, SE-11284 Stockholm, Sweden.
    Kvanta, Anders
    Department of Clinical Neuroscience, Section of Ophthalmology and Vision, Karolinska Institutet, St Erik’s Hospital, SE-11284 Stockholm, Sweden.
    Edholm, Dan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för genetik och patologi.
    Aspenström, Pontus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwiginstitutet för cancerforskning.
    Kissil, Joseph
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
    Claesson-Welsh, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för genetik och patologi.
    Shimono, Akihiko
    Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Chuou-ku, Kobe 650-0047, Japan.
    Holmgren, Lars
    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, SE-17176 Stockholm, Sweden.
    Angiomotin regulates endothelial cell migration during embryonic angiogenesis2007Ingår i: Genes & Development, ISSN 0890-9369, E-ISSN 1549-5477, Vol. 21, nr 16, s. 2055-2068Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The development of the embryonic vascular system into a highly ordered network requires precise control over the migration and branching of endothelial cells (ECs). We have previously identified angiomotin (Amot) as a receptor for the angiogenesis inhibitor angiostatin. Furthermore, DNA vaccination targeting Amot inhibits angiogenesis and tumor growth. However, little is known regarding the role of Amot in physiological angiogenesis. We therefore investigated the role of Amot in embryonic neovascularization during zebrafish and mouse embryogenesis. Here we report that knockdown of Amot in zebrafish reduced the number of filopodia of endothelial tip cells and severely impaired the migration of intersegmental vessels. We further show that 75% of Amot knockout mice die between embryonic day 11 (E11) and E11.5 and exhibit severe vascular insufficiency in the intersomitic region as well as dilated vessels in the brain. Furthermore, using ECs differentiated from embryonic stem (ES) cells, we demonstrate that Amot-deficient cells have intact response to vascular endothelial growth factor (VEGF) in regard to differentiation and proliferation. However, the chemotactic response to VEGF was abolished in Amot-deficient cells. We provide evidence that Amot is important for endothelial polarization during migration and that Amot controls Rac1 activity in endothelial and epithelial cells. Our data demonstrate a critical role for Amot during vascular patterning and endothelial polarization.

  • 55.
    Aasebö, Kristine Ö.
    et al.
    Univ Bergen, Dept Clin Sci, Bergen, Norway.
    Dragomir, Anca
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk och experimentell patologi.
    Sundström, Magnus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk och experimentell patologi.
    Mezheyeuski, Artur
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Edqvist, Per-Henrik D
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Eide, Geir Egil
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Lifestyle Epidemiol Grp, Bergen, Norway;Haukeland Hosp, Ctr Clin Res, Bergen, Norway.
    Pontén, Fredrik
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk och experimentell patologi.
    Pfeiffer, Per
    Odense Univ Hosp, Dept Oncol, Odense, Denmark.
    Glimelius, Bengt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Sorbye, Halfdan
    Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Oncol, Bergen, Norway.
    Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients2019Ingår i: Cancer Medicine, ISSN 2045-7634, E-ISSN 2045-7634, Vol. 8, nr 7, s. 3623-3635Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Immunotherapy for patients with microsatellite-instable (MSI-H) tumors or BRAF-inhibitors combination treatment for BRAF-mutated (mutBRAF) tumors in metastatic colorectal cancer (mCRC) is promising, but the frequency of these molecular changes in trial patients are low. Unselected population-based studies of these molecular changes are warranted.

    Methods: A population-based cohort of 798 mCRC patients in Scandinavia was studied. Patient and molecular tumor characteristics, overall survival (OS) and progression-free survival (PFS) were estimated.

    Results: Here, 40/583 (7%) tumor samples were MSI-H and 120/591 (20%) were mutBRAF; 87% of MSI-H tumors were mutBRAF (non-Lynch). Elderly (>75 years) had more often MSI-H (10% vs 6%) and MSI-H/mutBRAF (9% vs 4%) tumors. Response rate (5% vs 44%), PFS (4 vs 8 months), and OS (9 vs 18 months) after first-line chemotherapy was all significantly lower in patients with MSI-H compared to patients with microsatellite stable tumors. MSI-H and mutBRAF were both independent poor prognostic predictors for OS (P = 0.049, P < 0.001) and PFS (P = 0.045, P = 0.005) after first-line chemotherapy. Patients with MSI-H tumors received less second-line chemotherapy (15% vs 37%, P = 0.005).

    Conclusions: In unselected mCRC patients, MSI-H and mutBRAF cases were more common than previously reported. Patients with MSI-H tumors had worse survival, less benefit from chemotherapy, and they differed considerably from recent third-line immunotherapy trial patients as they were older and most had mutBRAF tumor (non-Lynch).

  • 56. Aavik, Einari
    et al.
    Lumivuori, Henri
    Leppänen, Olli
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Gävleborg.
    Wirth, Thomas
    Hakkinen, Sanna-Kaisa
    Braesen, Jan-Hinrich
    Beschorner, Ulrich
    Zeller, Thomas
    Braspenning, Maarten
    van Criekinge, Wim
    Makinen, Kimmo
    Yla-Herttuala, Seppo
    Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster2015Ingår i: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 36, nr 16, s. 993-U23Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Aims Genetics can explain just above 10% of the observed heritability in cardiovascular diseases. Epigenetics is about to provide some further explanations, but the information needed for that is in the accumulation phase. Genome-wide DNA methylation analysis has revealed thousands of genes, which are epigenetically differentially regulated in atherosclerotic plaques. Our results point to an additional level of complexity that needs to be integrated into the aetiology of atherogenesis.We conducted a genome-wide analysis to identify differentially methylated genes in atherosclerotic lesions. Methods DNA methylation at promoters, exons and introns was identified by massive parallel sequencing. Gene expression was analysed by microarrays, qPCR, immunohistochemistry and western blots. Results Globally, hypomethylation of chromosomal DNA predominates in atherosclerotic plaques and two-thirds of genes showing over 2.5-fold differential in DNA methylation are up-regulated in comparison to healthy mammary arteries. The imprinted chromatin locus 14q32 was identified for the first time as an extensively hypomethylated area in atherosclerosis with highly induced expression of miR127, -136, -410, -431, -432, -433 and capillary formation-associated gene RTL1. The top 100 list of hypomethylated promoters exhibited over 1000-fold enrichment for miRNAs, many of which mapped to locus 14q32. Unexpectedly, also gene body hypermethylation was found to correlate with stimulated mRNA expression. Conclusion Significant changes in genomic methylation were identified in atherosclerotic lesions. The most prominent gene cluster activated via hypomethylation was detected at imprinted chromosomal locus 14q32 with several clustered miRNAs that were up-regulated. These results suggest that epigenetic changes are involved in atherogenesis and may offer new potential therapeutic targets for vascular diseases.

  • 57.
    Abacan, MaryAnn
    et al.
    Univ Philippines Manila, Inst Human Genet, NIH, Manila, Philippines.
    Alsubaie, Lamia
    KASCH, King Abdulaziz Med City, Riyadh, Saudi Arabia.
    Barlow-Stewart, Kristine
    Univ Sydney, Fac Med & Hlth, Northern Clin Sch, Sydney, NSW, Australia.
    Caanen, Beppy
    Maastricht Univ, Dept Clin Genet, Med Ctr, Maastricht, Netherlands.
    Cordier, Christophe
    SYNLAB Genet, Dept Genet, Lausanne, Switzerland.
    Courtney, Eliza
    Natl Canc Ctr, Div Med Oncol, Canc Genet Serv, Singapore, Singapore.
    Davoine, Emeline
    Lausanne Univ Hosp CHUV, Lausanne, Switzerland.
    Edwards, Janice
    Univ South Carolina, Genet Counseling Program, Transnat Alliance Genet Counseling, Columbia, SC USA.
    Elackatt, Niby J.
    Cloudnine Hosp, Org Rare Dis India, Bangalore, Karnataka, India.
    Gardiner, Kate
    LifeLabs Genet, Toronto, ON, Canada.
    Guan, Yue
    Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA USA.
    Huang, Lian-Hua
    China Med Univ, Sch Nursing, Taichung, Taiwan;Natl Taiwan Univ, Coll Med, Sch Nursing, Taipei, Taiwan.
    Ingvoldstad, Charlotta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Livsstil och rehabilitering vid långvarig sjukdom. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa. Karolinska Univ Hosp, Ctr Fetal Med & Clin Genet, Stockholm, Sweden;Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden.
    Kejriwal, Sahil
    Univ Washington, Inst Publ Hlth Genet, Seattle, WA USA.
    Kim, Hyon J.
    Ajou Univ, Med Sch, Suwon, South Korea;Konyang Univ, Grad Sch, Suwon, South Korea.
    Lambert, Deborah
    Natl Rare Dis Off, Dublin, Ireland.
    Lantigua-Cruz, Paulina Araceli
    Univ Med Sci Havana, Havana, Cuba.
    Lee, Juliana M. H.
    Natl Univ Malaysia, Kuala Lumpur, Malaysia.
    Lodahl, Marianne
    Copenhagen Univ Hosp, Rigshosp, Dept Clin Genet, Copenhagen, Denmark.
    Lunde, Ashild
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
    Macaulay, Shelley
    Univ Witwatersrand, Fac Hlth Sci, Div Human Genet, Johannesburg, South Africa;Natl Hlth Lab Serv, Johannesburg, South Africa.
    Macciocca, Ivan
    Victorian Clin Genet Serv, Melbourne, Vic, Australia.
    Margarit, Sonia
    Clin Alemana Univ Desarrollo, Fac Med, Ctr Genet & Genom, Santiago, Chile.
    Middleton, Anna
    Soc & Eth Res Connecting Sci, Wellcome Genome Campus, Cambridge, England;Univ Cambridge, Fac Educ, Cambridge, England.
    Moldovan, Ramona
    Babes Bolyai Univ, Dept Psychol, Cluj Napoca, Romania.
    Ngeow, Joanne
    Natl Canc Ctr, Div Med Oncol, Canc Genet Serv, Singapore, Singapore.
    Obregon-Tito, Alexandra J.
    Univ Arkansas Med Sci, Little Rock, AR 72205 USA.
    Ormond, Kelly E.
    Stanford Univ, Sch Med, Dept Genet, Stanford, CA USA;Stanford Univ, Sch Med, Stanford Ctr Biomed Eth, Stanford, CA USA;Stanford Univ, Sch Med, 300 Pasteur Dr,MC 5208, Stanford, CA USA.
    Paneque, Milena
    Univ Porto, CGPP Ctr Predict & Prevent Genet, I3S, Porto, Portugal;Univ Porto, IBMC Inst Mol & Cell Biol, Porto, Portugal.
    Powell, Karen
    Cone Hlth Canc Ctr, Greensboro, NC USA.
    Sanghavi, Kunal
    Jackson Lab Genom Med, Farmington, CT USA.
    Scotcher, Diana
    Manchester Univ Hosp NHS Fdn Trust, St Marys Hosp, Manchester Ctr Genom Med, Manchester, Lancs, England.
    Scott, Jenna
    Univ British Columbia, Vancouver, BC, Canada.
    Juhe, Clara Serra
    Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Inst Hosp Mar Invest Med, Ctr Invest Biomed Red Enfermedades Raras, Barcelona, Spain.
    Shkedi-Rafid, Shiri
    Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel.
    Wessels, Tina-Marie
    Univ Cape Town, Div Human Genet, Cape Town, South Africa.
    Yoon, Sook-Yee
    Natl Univ Malaysia, Kuala Lumpur, Malaysia;Canc Res, Subang Jaya, Malaysia;Univ Malaya, Med Ctr, Kuala Lumpur, Malaysia.
    Wicklund, Catherine
    Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
    The Global State of the Genetic Counseling Profession2019Ingår i: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 27, nr 2, s. 183-197Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    The profession of genetic counseling (also called genetic counselling in many countries) began nearly 50 years ago in the United States, and has grown internationally in the past 30 years. While there have been many papers describing the profession of genetic counseling in individual countries or regions, data remains incomplete and has been published in diverse journals with limited access. As a result of the 2016 Transnational Alliance of Genetic Counseling (TAGC) conference in Barcelona, Spain, and the 2017 World Congress of Genetic Counselling in the UK, we endeavor to describe as fully as possible the global state of genetic counseling as a profession. We estimate that in 2018 there are nearly 7000 genetic counselors with the profession established or developing in no less than 28 countries.

  • 58.
    Abadpour, Shadab
    et al.
    Oslo Univ Hosp, Sect Transplant Surg, Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
    Göpel, Sven O.
    AstraZeneca R&D Gothenburg, Dept CVMD Biosci, Gothenburg, Sweden..
    Schive, Simen W.
    Oslo Univ Hosp, Sect Transplant Surg, Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
    Korsgren, Olle
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Foss, Aksel
    Oslo Univ Hosp, Sect Transplant Surg, Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
    Scholz, Hanne
    Oslo Univ Hosp, Sect Transplant Surg, Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
    Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis2017Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, artikel-id 1575Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    One of the key limitations to successful human islet transplantation is loss of islets due to stress responses pre- and post-transplantation. Nutrient deprivation and ER stress have been identified as important mechanisms leading to apoptosis. Glial Cell-line Derived Neurotrophic Factor (GDNF) has recently been found to promote islet survival after isolation. However, whether GDNF could rescue human islets from nutrient deprivation and ER stress-mediated apoptosis is unknown. Herein, by mimicking those conditions in vitro, we have shown that GDNF significantly improved glucose stimulated insulin secretion, reduced apoptosis and proinsulin: insulin ratio in nutrient deprived human islets. Furthermore, GDNF alleviated thapsigargin-induced ER stress evidenced by reduced expressions of IRE1 alpha and BiP and consequently apoptosis. Importantly, this was associated with an increase in phosphorylation of PI3K/AKT and GSK3B signaling pathway. Transplantation of ER stressed human islets pre- treated with GDNF under kidney capsule of diabetic mice resulted in reduced expressions of IRE1 alpha and BiP in human islet grafts with improved grafts function shown by higher levels of human C-peptide post-transplantation. We suggest that GDNF has protective and anti-apoptotic effects on nutrient deprived and ER stress activated human islets and could play a significant role in rescuing human islets from stress responses.

  • 59.
    Abadpour, Shadab
    et al.
    Oslo University Hospital, Oslo, Norway.
    Halvorsen, Bente
    Oslo University Hospital, Oslo, Norway.
    Sahraoui, Afaf
    University of Oslo, Oslo, Norway.
    Korsgren, Olle
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Aukrust, Pål
    Oslo University Hospital, Oslo, Norway.
    Scholz, Hanne
    Oslo University Hospital, Oslo, Norway.
    Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT2018Ingår i: Journal of Molecular Endocrinology, ISSN 0952-5041, E-ISSN 1479-6813, Vol. 60, nr 3, s. 171-183Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Interleukin (IL)-22 has recently been suggested as an anti-inflammatory cytokine that could protect the islet cells from inflammation- and glucose-induced toxicity. We have previously shown that the tumor necrosis factor family member, LIGHT can impair human islet function at least partly via pro-apoptotic effects. Herein, we aimed to investigate the protective role of IL-22 on human islets exposed to the combination of hyperglycemia and LIGHT. First, we found up-regulation of LIGHT receptors (LTβR and HVEM) in engrafted human islets exposed to hyperglycemia (>11 mM) for 17 days post transplantation by using a double islet transplantation mouse model as well as in human islets cultured with high glucose (HG) (20mM glucose) + LIGHT in vitro and this latter effect was attenuated by IL-22. The effect of HG + LIGHT impairing glucose stimulated insulin secretion was reversed by IL-22. The harmful effect of HG + LIGHT on human islet function seemed to involve enhanced endoplasmic reticulum stress evidenced by up-regulation of p-IRE1α and BiP, elevated secretion of pro-inflammatory cytokines (IL-6, IL-8, IP-10 and MCP-1) and the pro-coagulant mediator tissue factor (TF) release and apoptosis in human islets, whereas all these effects were at least partly reversed by IL-22. Our findings suggest that IL-22 could counteract the harmful effects of LIGHT/hyperglycemia on human islet cells and potentially support the strong protective effect of IL-22 on impaired islet function and survival.

  • 60. Abarca-Gómez, L.
    et al.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Lytsy, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Socialmedicinsk epidemiologi.
    Sundström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.
    Yngve, Agneta
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för kostvetenskap.
    Ezzati, M
    Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults.2017Ingår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 390, nr 10113, s. 2627-2642Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults.

    METHODS: We pooled 2416 population-based studies with measurements of height and weight on 128·9 million participants aged 5 years and older, including 31·5 million aged 5-19 years. We used a Bayesian hierarchical model to estimate trends from 1975 to 2016 in 200 countries for mean BMI and for prevalence of BMI in the following categories for children and adolescents aged 5-19 years: more than 2 SD below the median of the WHO growth reference for children and adolescents (referred to as moderate and severe underweight hereafter), 2 SD to more than 1 SD below the median (mild underweight), 1 SD below the median to 1 SD above the median (healthy weight), more than 1 SD to 2 SD above the median (overweight but not obese), and more than 2 SD above the median (obesity).

    FINDINGS: Regional change in age-standardised mean BMI in girls from 1975 to 2016 ranged from virtually no change (-0·01 kg/m(2) per decade; 95% credible interval -0·42 to 0·39, posterior probability [PP] of the observed decrease being a true decrease=0·5098) in eastern Europe to an increase of 1·00 kg/m(2) per decade (0·69-1·35, PP>0·9999) in central Latin America and an increase of 0·95 kg/m(2) per decade (0·64-1·25, PP>0·9999) in Polynesia and Micronesia. The range for boys was from a non-significant increase of 0·09 kg/m(2) per decade (-0·33 to 0·49, PP=0·6926) in eastern Europe to an increase of 0·77 kg/m(2) per decade (0·50-1·06, PP>0·9999) in Polynesia and Micronesia. Trends in mean BMI have recently flattened in northwestern Europe and the high-income English-speaking and Asia-Pacific regions for both sexes, southwestern Europe for boys, and central and Andean Latin America for girls. By contrast, the rise in BMI has accelerated in east and south Asia for both sexes, and southeast Asia for boys. Global age-standardised prevalence of obesity increased from 0·7% (0·4-1·2) in 1975 to 5·6% (4·8-6·5) in 2016 in girls, and from 0·9% (0·5-1·3) in 1975 to 7·8% (6·7-9·1) in 2016 in boys; the prevalence of moderate and severe underweight decreased from 9·2% (6·0-12·9) in 1975 to 8·4% (6·8-10·1) in 2016 in girls and from 14·8% (10·4-19·5) in 1975 to 12·4% (10·3-14·5) in 2016 in boys. Prevalence of moderate and severe underweight was highest in India, at 22·7% (16·7-29·6) among girls and 30·7% (23·5-38·0) among boys. Prevalence of obesity was more than 30% in girls in Nauru, the Cook Islands, and Palau; and boys in the Cook Islands, Nauru, Palau, Niue, and American Samoa in 2016. Prevalence of obesity was about 20% or more in several countries in Polynesia and Micronesia, the Middle East and north Africa, the Caribbean, and the USA. In 2016, 75 (44-117) million girls and 117 (70-178) million boys worldwide were moderately or severely underweight. In the same year, 50 (24-89) million girls and 74 (39-125) million boys worldwide were obese.

    INTERPRETATION: The rising trends in children's and adolescents' BMI have plateaued in many high-income countries, albeit at high levels, but have accelerated in parts of Asia, with trends no longer correlated with those of adults.

  • 61. Abbas, ZA
    et al.
    Steenari, BM
    Lindqvist, Olle
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.
    A study of Cr(VI) in ashes from fluidized bed combustion of municipalsolid waste: leaching, secondary reactions and the applicability of somespeciation methods.2001Ingår i: Waste Manag, Vol. 21, s. 725-Artikel i tidskrift (Refereegranskat)
  • 62.
    Abbasi, Mina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Translational aspects of unbound brain to plasma concentration ratios2012Självständigt arbete på avancerad nivå (yrkesexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Introduction:  The unbound brain-to-plasma concentration ratio (Kp,uu,brain) is one of the most important indicators for brain penetration in the area of CNS drug discovery and development. Kp,uu,brain can be calculated by combining the total brain-to-plasma concentration ratio (Kp,brain),  the brain free fraction (fu,brain) and  the plasma free fraction (fu,p).

    Aim:  This study has three purposes, to calculate Kp,uu,brain from publications in humans,  to collect data regarding species differences in Kp,uu,brain and to see whether Kp,uu,brain in humans differs in different  brain regions or not.

    Materials and Methods:  The values of Kp, brain were derived from positron emission tomography (PET), MRS (Magnetic Resonance Spectroscopy), and brain surgery for tumor removal. fu,brain and fu,p were collected from brain homogenate, equilibrium dialysis and ultrafiltration studies.

    Results:  Data on Kp,brain was sparse in the literature. Kp,uu,brain was calculated for sixteen different drugs in humans. According to the calculation, nine of these sixteen compounds were found to be actively influxed into the brain, six were actively effluxed from the BBB and one had a passive diffusion. Depending on the compound, Kp,uu,brain was higher or smaller in humans compared to mice and rats.  Kp,uu,brain for five compounds were calculated for different brain regions. Four compounds had a higher Kp,uu,brain value in almost all other regions than the cerebellum and one had a higher Kp,uu,brain in cerebellum than in the other regions.

    Conclusions:  No definite conclusion on Kp,uu,brain in humans, species differences in Kp,uu,brain  or Kp,uu,brain  in different human brain regions could be reached in this study. In view of the importance of Kp,uu,brain  in CNS drug discovery and development, more studies on Kp,uu,brain in humans and in the other species are required.

  • 63.
    Abbasinejad Enger, Shirin
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för onkologi, radiologi och klinisk immunologi.
    Dosimetry Studies of Different Radiotherapy Applications using Monte Carlo Radiation Transport Calculations2008Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Developing radiation delivery systems for optimisation of absorbed dose to the target without normal tissue toxicity requires advanced calculations for transport of radiation. In this thesis absorbed dose and fluence in different radiotherapy applications were calculated by using Monte Carlo (MC) simulations.

    In paper I-III external neutron activation of gadolinium (Gd) for intravascular brachytherapy (GdNCB) and tumour therapy (GdNCT) was investigated. MC codes MCNP and GEANT4 were compared. MCNP was chosen for neutron capture reaction calculations. Gd neutron capture reaction includes both very short range (Auger electrons) and long range (IC electrons and gamma) products. In GdNCB the high-energetic gamma gives an almost flat absorbed dose delivery pattern, up to 4 mm around the stent. Dose distribution at the edges and inside the stent may prevent stent edge and in-stent restenosis. For GdNCT the absorbed dose from prompt gamma will dominate over the dose from IC and Auger electrons in an in vivo situation. The absorbed dose from IC electrons will enhance the total absorbed dose in the tumours and contribute to the cell killing.

    In paper IV a model for calculation of inter-cluster cross-fire radiation dose from β-emitting radionuclides in a breast cancer model was developed. GEANT4 was used for obtaining absorbed dose. The dose internally in cells binding the isotope (self-dose) increased with decreasing β-energy except for the radionuclides with substantial amounts of conversion electrons and Auger electrons. An effective therapy approach may be a combination of radionuclides where the high self-dose from nuclides with low β-energy should be combined with the inter-cell cluster cross-fire dose from high energy β-particles.

    In paper V MC simulations using correlated sampling together with importance sampling were used to calculate spectra perturbations in detector volumes caused by the detector silicon chip and its encapsulation. Penelope and EGSnrc were used and yielded similar results. The low energy part of the electron spectrum increased but to a less extent if the silicon detector was encapsulated in low z-materials.

    Delarbeten
    1. Monte Carlo calculations of thermal neutron capture in gadolinium: a comparison of GEANT4 and MCNP with measurements.
    Öppna denna publikation i ny flik eller fönster >>Monte Carlo calculations of thermal neutron capture in gadolinium: a comparison of GEANT4 and MCNP with measurements.
    2006 Ingår i: Medical Physics, ISSN 0094-2405, Vol. 33, nr 2, s. 337-341Artikel i tidskrift (Refereegranskat) Published
    Identifikatorer
    urn:nbn:se:uu:diva-97526 (URN)
    Tillgänglig från: 2008-09-19 Skapad: 2008-09-19Bibliografiskt granskad
    2. Gadolinium neutron capture brachytherapy (GdNCB), a new treatment method for intravascular brachytherapy.
    Öppna denna publikation i ny flik eller fönster >>Gadolinium neutron capture brachytherapy (GdNCB), a new treatment method for intravascular brachytherapy.
    2006 Ingår i: Medical Physics, ISSN 0094-2405, Vol. 33, nr 1, s. 46-51Artikel i tidskrift (Refereegranskat) Published
    Identifikatorer
    urn:nbn:se:uu:diva-97527 (URN)
    Tillgänglig från: 2008-09-19 Skapad: 2008-09-19Bibliografiskt granskad
    3. Dosimetry for gadolinium neutron capture therapy (GdNCT)
    Öppna denna publikation i ny flik eller fönster >>Dosimetry for gadolinium neutron capture therapy (GdNCT)
    Manuskript (Övrigt vetenskapligt)
    Identifikatorer
    urn:nbn:se:uu:diva-97528 (URN)
    Tillgänglig från: 2008-09-19 Skapad: 2008-09-19 Senast uppdaterad: 2010-01-13Bibliografiskt granskad
    4. Cross-fire doses from β-emitting radionuclides in targeted radiotherapy: A theoretical study based on experimentally measured tumor characteristics
    Öppna denna publikation i ny flik eller fönster >>Cross-fire doses from β-emitting radionuclides in targeted radiotherapy: A theoretical study based on experimentally measured tumor characteristics
    2008 (Engelska)Ingår i: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 53, nr 7, s. 1909-1920Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    A mathematical model based upon histological findings of cell cluster distributions in primary breast cancers and lymph node metastases was developed. The model is unique because it accounts for tumor cell cluster formations within both primary tumors and metastases. The importance of inter-cell cluster cross-fire radiation dose for beta-emitting radionuclides of different energies was studied. The cell clusters were simulated as spheres with 15, 25 and 50 microm radii having a homogeneous radioactivity distribution. The self-dose as well as the dose distribution around the spheres was calculated for seven radionuclides, (90)Y, (188)Re, (32)P, (186)Re, (159)Gd, (131)I and (177)Lu using the GEANT4 Monte Carlo code. Generally, the self-dose was decreasing with increasing energy of the emitted beta particles. An exception was (188)Re which, compared to (32)P, had higher beta energy as well as higher self-dose. This was due to the higher emission of conversion and Auger electrons in the (188)Re-decay. When the cell clusters had a mean distance that was shorter than the maximum range of beta-particles, then the inter-cluster cross-fire radiation contributed significantly to the absorbed dose. Thus, high-energy beta-particles may, in spite of a low self-dose to single clusters, still be favorable to use due to the contribution of inter-cluster cross-fire radiation.

    Nyckelord
    Cancer, tumor, radiation, therapy
    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:uu:diva-97529 (URN)10.1088/0031-9155/53/7/007 (DOI)000254175900007 ()18364546 (PubMedID)
    Tillgänglig från: 2008-09-19 Skapad: 2008-09-19 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
    5. Determination of self perturbations of spectra in detectors in photon fields
    Öppna denna publikation i ny flik eller fönster >>Determination of self perturbations of spectra in detectors in photon fields
    Manuskript (Övrigt vetenskapligt)
    Identifikatorer
    urn:nbn:se:uu:diva-97530 (URN)
    Tillgänglig från: 2008-09-19 Skapad: 2008-09-19 Senast uppdaterad: 2010-01-13Bibliografiskt granskad
  • 64.
    Abbasinejad Enger, Shirin
    et al.
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för onkologi, radiologi och klinisk immunologi.
    Fortin, Marc-André
    Lundqvist, Hans
    Munck af Rosenschöld, Per
    Dosimetry for gadolinium neutron capture therapy (GdNCT)Manuskript (Övrigt vetenskapligt)
  • 65.
    Abbasinejad Enger, Shirin
    et al.
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för onkologi, radiologi och klinisk immunologi.
    Munck af Rosenschöld, Per
    Rezaei, Arash
    Lundqvist, Hans
    Monte Carlo calculations of thermal neutron capture in gadolinium: a comparison of GEANT4 and MCNP with measurements.2006Ingår i: Medical Physics, ISSN 0094-2405, Vol. 33, nr 2, s. 337-341Artikel i tidskrift (Refereegranskat)
  • 66.
    Abbasinejad Enger, Shirin
    et al.
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för onkologi, radiologi och klinisk immunologi.
    Rezaei, Arash
    Munck af Rosenschöld, Per
    Lundqvist, Hans
    Gadolinium neutron capture brachytherapy (GdNCB), a new treatment method for intravascular brachytherapy.2006Ingår i: Medical Physics, ISSN 0094-2405, Vol. 33, nr 1, s. 46-51Artikel i tidskrift (Refereegranskat)
  • 67.
    Abbaspour, Kristina
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Sjukgymnastik.
    Lindén, Charlotta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Sjukgymnastik.
    Primärvårdsjukgymnastens yrkesroll och kompetens, nu och i framtiden.2010Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 68.
    Abberud, Madelene
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Time to first antibiotic administration in The Alfred Emergency and Trauma Centre for suspected febrile neutropenia: a retrospective chart review2012Självständigt arbete på avancerad nivå (yrkesexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Introduction: Febrile neutropenia (FN) is a frequent complication of chemotherapy use in cancer patients. There is evidence to suggest that the time to antibiotic administration is associated with increase survival and effective clinical outcome. The Australian consensus guidelines for the management of FN in adult cancer patients recommends treatment within 30 minutes to patients with features of systemic compromise. A study performed at The Alfred Hospital in 2010 revealed a median time of 145 minutes to first antibiotic administration. A new guideline was therefore developed and education was implemented. This study was conducted to evaluate the intervention. Aim: To determine time to first antibiotic prescribing and administration for patients with suspected FN presenting to the Alfred Emergency and Trauma centre. Materials and Methods: The electronic medical record of 112 episodes of suspected FN presenting between March and August 2012 were reviewed.  Data were retrospective collected according to a FN data spreadsheet. An observational study were also performed at  The Alfred Emergency and Trauma centre during October and November 2012 to determine time to first antimicrobial prescribing, because this data could not be collected from the electronic medical record. Results: The median time from presentation to antibiotic prescribing was 68 minutes. The median time from presentation to antibiotic administration was 121 minutes. Conclusions: The implementation of the new guidelines has reduced the time with 16.6%, but the target first antibiotic administration within 30 minutes has not been reached.

  • 69.
    Abbey-Lee, Robin N.
    et al.
    Linkoping Univ, IFM Biol, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden.
    Uhrig, Emily J.
    Linkoping Univ, IFM Biol, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden.
    Zidar, Josefina
    Linkoping Univ, IFM Biol, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden.
    Favati, Anna
    Stockholm Univ, Dept Zool, Stockholm, Sweden.
    Almberg, Johan
    Linkoping Univ, IFM Biol, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden.
    Dahlbom, Josefin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysiologi.
    Winberg, Svante
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysiologi.
    Lövlie, Hanne
    Linkoping Univ, IFM Biol, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden.
    The Influence of Rearing on Behavior, Brain Monoamines, and Gene Expression in Three-Spined Sticklebacks2018Ingår i: Brain, behavior, and evolution, ISSN 0006-8977, E-ISSN 1421-9743, Vol. 91, nr 4, s. 201-213Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The causes of individual variation in behavior are often not well understood, and potential underlying mechanisms include both intrinsic and extrinsic factors, such as early environmental, physiological, and genetic differences. In an exploratory laboratory study, we raised three-spined sticklebacks (Gasterosteus aculeatus) under 4 different environmental conditions (simulated predator environment, complex environment, variable social environment, and control). We investigated how these manipulations related to behavior, brain physiology, and gene expression later in life, with focus on brain dopamine and serotonin levels, turnover rates, and gene expression. The different rearing environments influenced behavior and gene expression, but did not alter monoamine levels or metabolites. Specifically, compared to control fish, fish exposed to a simulated predator environment tended to be less aggressive, more exploratory, and more neophobic; and fish raised in both complex and variable social environments tended to be less neophobic. Exposure to a simulated predator environment tended to lower expression of dopamine receptor DRD4A, a complex environment increased expression of dopamine receptor DRD1B, while a variable social environment tended to increase serotonin receptor 5-HTR2B and serotonin transporter SLC6A4A expression. Despite both behavior and gene expression varying with early environment, there was no evidence that gene expression mediated the relationship between early environment and behavior. Our results confirm that environmental conditions early in life can affect phenotypic variation. However, the mechanistic pathway of the monoaminergic systems translating early environmental variation into observed behavioral responses was not detected.

  • 70. Abbott, A. L.
    et al.
    Adelman, M. A.
    Alexandrov, A. V.
    Barnett, H. J. M.
    Beard, J.
    Bell, P.
    Björck, Martin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Kärlkirurgi.
    Blacker, D.
    Buckley, C. J.
    Cambria, R. P.
    Comerota, A. J.
    Connolly, E. S., Jr.
    Davies, A. H.
    Eckstein, H. H.
    Faruqi, R.
    Fraedrich, G.
    Gloviczki, P.
    Hankey, G. J.
    Harbaugh, R. E.
    Heldenberg, E.
    Kittner, S. J.
    Kleinig, T. J.
    Mikhailidis, D. P.
    Moore, W. S.
    Naylor, R.
    Nicolaides, A.
    Paraskevas, K. I.
    Pelz, D. M.
    Prichard, J. W.
    Purdie, G.
    Ricco, J. B.
    Riles, T.
    Rothwell, P.
    Sandercock, P.
    Sillesen, H.
    Spence, J. D.
    Spinelli, F.
    Tan, A.
    Thapar, A.
    Veith, F. J.
    Zhou, W.
    Why the United States Center for Medicare and Medicaid Services (CMS) Should not Extend Reimbursement Indications for Carotid Artery Angioplasty/Stenting2012Ingår i: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 43, nr 3, s. 247-251Artikel i tidskrift (Refereegranskat)
  • 71. Abbott, A. L.
    et al.
    Adelman, M. A.
    Alexandrov, A. V.
    Barnett, H. J. M.
    Beard, J.
    Bell, P.
    Björck, Martin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Kärlkirurgi.
    Blacker, D.
    Buckley, C. J.
    Cambria, R. P.
    Comerota, A. J.
    Connolly, E. Sander
    Davies, A. H.
    Eckstein, H. -H
    Faruqi, R.
    Fraedrich, G.
    Gloviczki, P.
    Hankey, G. J.
    Harbaugh, R. E.
    Heldenberg, E.
    Kittner, S. J.
    Kleinig, T. J.
    Mikhailidis, D. P.
    Moore, W. S.
    Naylor, R.
    Nicolaides, A.
    Paraskevas, K. I.
    Pelz, D. M.
    Prichard, J. W.
    Purdie, G.
    Ricco, J. -B
    Riles, T.
    Rothwell, P.
    Sandercock, P.
    Sillesen, H.
    Spence, J. D.
    Spinelli, F.
    Tan, A.
    Thapar, A.
    Veith, F. J.
    Zhou, Wei
    Why the United States Center for Medicare and Medicaid Services (CMS) should not extend reimbursement indications for carotid artery angioplasty/stenting2012Ingår i: International Journal of Angiology, ISSN 0392-9590, E-ISSN 1827-1839, Vol. 31, nr 1, s. 85-89Artikel i tidskrift (Refereegranskat)
  • 72. Abbott, Anne L.
    et al.
    Adelman, Mark A.
    Alexandrov, Andrei V.
    Barber, P. Alan
    Barnett, Henry J. M.
    Beard, Jonathan
    Bell, Peter
    Björck, Martin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Kärlkirurgi.
    Blacker, David
    Bonati, Leo H.
    Brown, Martin M.
    Buckley, Clifford J.
    Cambria, Richard P.
    Castaldo, John E.
    Comerota, Anthony J.
    Connolly, E. Sander, Jr.
    Dalman, Ronald L.
    Davies, Alun H.
    Eckstein, Hans-Henning
    Faruqi, Rishad
    Feasby, Thomas E.
    Fraedrich, Gustav
    Gloviczki, Peter
    Hankey, Graeme J.
    Harbaugh, Robert E.
    Heldenberg, Eitan
    Hennerici, Michael G.
    Hill, Michael D.
    Kleinig, Timothy J.
    Mikhailidis, Dimitri P.
    Moore, Wesley S.
    Naylor, Ross
    Nicolaides, Andrew
    Paraskevas, Kosmas I.
    Pelz, David M.
    Prichard, James W.
    Purdie, Grant
    Ricco, Jean-Baptiste
    Ringleb, Peter A.
    Riles, Thomas
    Rothwell, Peter M.
    Sandercock, Peter
    Sillesen, Henrik
    Spence, J. David
    Spinelli, Francesco
    Sturm, Jonathon
    Tan, Aaron
    Thapar, Ankur
    Veith, Frank J.
    Wijeratne, Tissa
    Zhou, Wei
    Why Calls for More Routine Carotid Stenting Are Currently Inappropriate An International, Multispecialty, Expert Review and Position Statement2013Ingår i: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 44, nr 4, s. 1186-1190Artikel i tidskrift (Refereegranskat)
  • 73. Abbott, Anne L
    et al.
    Adelman, Mark A
    Alexandrov, Andrei V
    Barnett C C, Henry J M
    Beard, Jonathan
    Bell, Peter
    Björck, Martin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Kärlkirurgi.
    Blacker, David
    Buckley, Clifford J
    Cambria, Richard P
    Comerota, Anthony J
    Connolly, E Sander
    Davies, Alun H
    Eckstein, Hans-Henning
    Faruqi, Rishad
    Fraedrich, Gustav
    Gloviczki, Peter
    Hankey, Graeme J
    Harbaugh, Robert E
    Heldenberg, Eitan
    Kittner, Steven J
    Kleinig, Timothy J
    Mikhailidis, Dimitri P
    Moore, Wesley S
    Naylor, Ross
    Nicolaides, Andrew
    Paraskevas, Kosmas I
    Pelz, David M
    Prichard, James W
    Purdie, Grant
    Ricco, Jean-Baptiste
    Riles, Thomas
    Rothwell, Peter
    Sandercock, Peter
    Sillesen, Henrik
    Spence, J David
    Spinelli, Francesco
    Tan, Aaron
    Thapar, Ankur
    Veith, Frank J
    Zhou, Wei
    Why the US Center for Medicare and Medicaid Services Should Not Extend Reimbursement Indications for Carotid Artery Angioplasty/Stenting2012Ingår i: Angiology, ISSN 0003-3197, E-ISSN 1940-1574, Vol. 63, nr 8, s. 639-644Artikel i tidskrift (Refereegranskat)