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  • 51.
    Freitag, Fabio Batista
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Univ Fed Rio Grande do Norte, Lab Sensory Ecol, BR-59072970 Natal, RN, Brazil; Univ Fed Rio Grande do Norte, Lab Adv Study Primates, BR-59072970 Natal, RN, Brazil.
    Pessoa, Daniel Marques Almeida
    Univ Fed Rio Grande do Norte, Lab Sensory Ecol, BR-59072970 Natal, RN, Brazil; Univ Fed Rio Grande do Norte, Lab Adv Study Primates, BR-59072970 Natal, RN, Brazil.
    Effect of luminosity on color discrimination of dichromatic marmosets (Callithrix jacchus)2012Ingår i: Optical Society of America. Journal A: Optics, Image Science, and Vision, ISSN 1084-7529, E-ISSN 1520-8532, Vol. 29, nr 2, s. A216-22Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Psychophysical data have shown that under mesopic conditions cones and rods can interact, improving color vision. Since electrophysiological data have suggested that rods of dichromatic marmosets appear to be active at higher luminance, we aimed to investigate the effect of different levels of sunlight on the foraging abilities of male dichromatic marmosets. Captive marmosets were observed under three different conditions, with respect to their performance in detecting colored food items against a green background. Compared to high and low light intensities, intermediate luminosities significantly increased detection of orange targets by male dichromats, an indication of rod intrusion.

  • 52. Frennesson, Christina I.
    et al.
    Wadelius, Claes
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik.
    Nilsson, Sven Erik G.
    Best vitelliform macular dystrophy in a Swedish family: genetic analysis and a seven-year follow-up of photodynamic treatment of a young boy with choroidal neovascularization2014Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 92, nr 3, s. 238-242Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Abstract. Purpose: To determine the mutation in a Swedish family with Best disease (vitelliform macular dystrophy; VMD) and to investigate the short- and long-term effects of photodynamic treatment (PDT) on subretinal neovascularization in a young boy. Methods: The five members of three generations of a family with VMD underwent a thorough ophthalmological examination, including best-corrected visual acuity (VA), visual field, colour vision, biomicroscopy of the posterior segment (dilated), fundus photography and electro-oculography (EOG). For the proband, an eleven-year-old boy, his father and grandfather, dark adaptation test, angiography and electroretinography (ERG) were also performed. After PCR amplification, the genotype was determined by cleavage with restriction enzyme, specific for the W93C allele. Results: Four family members had an abnormal EOG response. All showed the W93C mutation in the VMD2 gene. Visual acuity ranged from 20/20 to 20/250. The fundus manifestations varied from minor pigmentary changes over egg yolk-like lesions to chorioretinal atrophy, and fluorescein angiography showed corresponding pathology. In the proband, VA decreased during follow-up from 0.5 (20/40) to 0.08 (20/250) due to a subfoveal neovascularization with haemorrhage, and PDT with visudyne was begun. The haemorrhage resolved within 2 months, and after three treatments, VA had increased to 0.25 (20/80). One year later, acuity had improved to 0.5 (20/40), and this result was stable throughout the 7 years of the follow-up. Conclusion: The mutation was determined to be W93C, the most common mutation in VMD in Sweden. In an eleven-year-old boy with subretinal neovascularization, PDT seemed to be beneficial also in a long-term follow-up.

  • 53.
    Galichanin, Konstantin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Exposure to subthreshold dose of UVR-B induces apoptosis in the lens epithelial cells and does not in the lens cortical fibre cells2017Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 95, nr 8, s. 834-838Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: The aim of this study was to investigate in which part of the lens invivo exposure to subthreshold dose of UVR-B radiation induces apoptosis.

    Methods: Twenty 6-week-old female albino Sprague-Dawley rats were exposed to subthreshold dose (1kJ/m(2)) of UVR-B unilaterally and killed at 120hr after exposure. Lenses were enucleated and dissected on three regions: the lens epithelium, the cortex and the nucleus. The lens nucleus then was removed. Apoptosis markers p53 and caspase 3 were used to study apoptosis in the lens regions. qRT-PCR and Western blot were utilized to analyse the lenses.

    Results: TP53 and CASP3 mRNA expressions are increased in exposed lenses, both in the lens epithelium and in the cortex regions, in relation to non-exposed lenses. Expression of p53 protein is increased in exposed lens epithelium in relation to non-exposed lens epithelium. Caspase 3 protein is expressed in exposed lens epithelial cells, while it is not expressed in non-exposed lens epithelial cells. p53 and caspase 3 proteins are not expressed in either exposed nor non-exposed lens fibre cells.

    Conclusion: Exposure to UVR-B increases mRNA transcription of apoptosis marker p53 invivo in both regions of the lens and of apoptosis marker caspase 3 in the lens cortex. Exposure to UVR-B increases p53 and caspase 3 proteins expression just in the lens epithelium. In vivo exposure to subthreshold dose of UVR-B induces apoptosis in the lens epithelial cells and does not in the lens fibre cells.

  • 54.
    Galichanin, Konstantin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Svedlund, Jessica
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Endokrinkirurgi.
    Söderberg, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Kinetics of GADD45a, TP53 and CASP3 gene expression in the rat lens in vivo in response to exposure to double threshold dose of UV-B radiation2012Ingår i: Experimental Eye Research, ISSN 0014-4835, E-ISSN 1096-0007, Vol. 97, nr 1, s. 19-23Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The purpose of the present study was to investigate the evolution of expression of mRNA message for the genes for the genome stress sensor GADD45α, the apoptosis initiator TP53 and the apoptosis executor CASP3 in the rat lens in vivo in response to exposure to UVR around 300 nm. Forty six week old female albino Sprague-Dawley rats were unilaterally exposed to double threshold dose for cataract induction, 8 kJ/m2 (8.9 W/m2 for 15 min), of UVR (λmax = 300 nm). The animals were sacrificed at 1, 5, 24 and 120 h following exposure to UVR-B. For each of the GADD45α, TP53 and CASP3 genes, respectively, mRNA expression in the lenses was measured by quantitative RT-PCR. It was found that expression of mRNA for GADD45α transiently increases between 5 and 24 h after exposure. TP53 is slightly downregulated in exposed lenses at 1 and 5 h after exposure and thereafter the mRNA expression increases with a constant rate of 9.4∗10−3 rel. units/h to a 1.8 fold increase at 120 h after exposure. Expression of mRNA for CASP3 is downregulated at 1, 5 and 24 h after in vivo exposure and then increases with a constant rate of 4.7∗10−3 rel. units/h, upto a 1.3 fold upregulation at 120 h. Double threshold dose of UVR, for short delay onset of cataract, in vivo causes a transient upregulation of the stress sensor GADD45α, a concurrent downregulation of TP53 and CASP3, followed by a constant upregulation of TP53 that precedes a constant upregulation of CASP3.

  • 55.
    Galichanin, Konstantin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Yu, Zhaohua
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Söderberg, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Upregulation of GADD45a, TP53 and CASP3 mRNA expression in the rat lens after in vivo exposure to sub-threshold exposure to UVR B2014Ingår i: Journal of Ocular Biology, ISSN 2334-2838, Vol. 2, nr 1, s. 5-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose:

    The objective of the present study was to investigate the evolution of mRNA expression of the stress sensor GADD45α, the apoptosis initiator TP53 and the apoptosis executor CASP3 in the rat lens after in vivo exposure to sub-threshold dose of UVR-B.

    Methods:

    Forty six-week-old female albino Sprague-Dawley rats were unilaterally exposed to a sub-threshold dose, 1 kJ/m2 (1.1 W/m2 for 15 min), of UVR (λmax = 300 nm). Anesthetized and dilated eyes were exposed to UVB radiation. The animals were sacrificed at 1, 5, 24 and 120 h post-exposure. mRNA expression of the GADD45α, TP53 and CASP3 genes in the lenses was measured by quantitative RT‑PCR, and fold change in mRNA expression between exposed and unexposed lenses was calculated.

    Results:

    mRNA expression for GADD45α increased to a 1.2 fold change at 1 h after exposure and then returned to no change at 120 h. mRNA expression for TP53 increased with a regression coefficient of 0.04 h-1 to a maximum of 1.67 fold change. mRNA expression for CASP3 increased with a regression coefficient of 4.5 x10-3 rel. units/h to a 1.46 fold change at 120 h after exposure.

    Conclusions:

    A sub-threshold in vivo exposure to UVR-B causes a transient upregulation of the stress sensor GADD45α at 1 h after exposure, a saturating upregulation of TP53 and a subsequent constant upregulation of CASP3 in the rat lens.

  • 56.
    Ghaderi Berntsson, Shala
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Landtblom: Neurovetenskap.
    Kristoffersson, Anna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Landtblom: Neurovetenskap. Department of Clinical and Experimental Medicine, Neurology, Medical Faculty, University of Linköping, Linköping, Sweden.
    Daniilidou, Makrina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Landtblom: Neurovetenskap.
    Dahl, Niklas
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik.
    Ekström, Curt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Söderberg: Oftalmiatrik.
    Semnic, Robert
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.
    Markström, Agneta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Niemelä, Valter
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Landtblom: Neurovetenskap.
    Partinen, Markku
    Vitalmed Research Center, Helsinki Sleep Clinic, Helsinki, Finland;Department of Clinical Neurosciences, University of Helsinki, Helsinki, Finland.
    Hallböök, Finn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Hallböök: Stamceller, retinal utveckling och regeneration.
    Landtblom, Anne-Marie
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Landtblom: Neurovetenskap. Department of Clinical and Experimental Medicine, Neurology, Medical Faculty, University of Linköping, Linköping, Sweden.
    Aniridia with PAX6 mutations and narcolepsy2020Ingår i: Journal of Sleep Research, ISSN 0962-1105, E-ISSN 1365-2869, Vol. 29, nr 6, artikel-id e12982Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PAX6 gene mutations cause a variety of eye and central nervous system (CNS) abnormalities. Aniridia is often accompanied by CNS abnormalities such as pineal gland atrophy or hypoplasia, leading to disturbed circadian rhythm and sleep disorders. Less is known on the coincidence of narcolepsy in this patient group. We aimed to find out whether the circadian rhythm or sleep-wake structure was affected in patients with aniridia. Four members of a family segregating with congenital aniridia in two generations were included in the study. The patients were subjected to genetic testing for a PAX6 mutation, multiple sleep latency test, whole-brain magnetic resonance imaging (MRI), hypocretin-1 in cerebrospinal fluid, and Human Leukocyte Antigen DQ beta1*06:02. All four members were heterozygous for the pathogenic c.959-1G>A mutation in the PAX6 gene. Sleep disturbance was observed in all family members. The index patient was diagnosed with narcolepsy. MRI showed a hypoplastic pineal gland in all members. We describe the first case of a patient with PAX6 haploinsufficiency, aniridia and pineal gland hypoplasia diagnosed with narcolepsy type-1, suggesting a complex sleep disorder pathogenesis.

  • 57. Gole, Glen A.
    et al.
    Ells, Anna L.
    Katz, Ximena
    Holmström, Gerd
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Oftalmiatrik.
    Fielder, Alistair R.
    Capone, Antonio
    Flynn, John T.
    Good, William G.
    Holmes, Jonathan M.
    McNamara, J. Arch
    Palmer, Earl A.
    Quinn, Graham E.
    Shapiro, Michael J.
    Trese, Michael G. J.
    Wallace, David K.
    The International Classification of Retinopathy of Prematurity Revisited: An International Committee for the Classification of Retinopathy of Prematurity2005Ingår i: Arch Ophthalmol, Vol. 123, s. 991-999Artikel i tidskrift (Refereegranskat)
  • 58.
    Granstam, Elisabet
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Dept Ophthalmol, S-72189 Västerås, Region Vastmanl, Sweden..
    Aurell, Sandra
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Dept Ophthalmol, S-72189 Västerås, Region Vastmanl, Sweden..
    Sjövall, Kersti
    Dept Ophthalmol, S-72189 Västerås, Region Vastmanl, Sweden..
    Paul, Anna
    Dept Ophthalmol, S-72189 Västerås, Region Vastmanl, Sweden..
    Switching anti-VEGF agent for wet AMD: evaluation of impact on visual acuity, treatment frequency and retinal morphology in a real-world clinical setting2021Ingår i: Graefe's Archives for Clinical and Experimental Ophthalmology, ISSN 0721-832X, E-ISSN 1435-702X, Vol. 259, nr 8, s. 2085-2093Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose The aim of the present cross-sectional real-world study is to evaluate the impact of switch of anti-VEGF agent from ranibizumab to aflibercept on visual acuity, treatment frequency and retinal morphology after 12 months in eyes with ongoing chronic treatment for wet age-related macular degeneration (AMD) compared to eyes not subjected to switch of anti-VEGF agent.

    Methods Data was obtained retrospectively from the Swedish Macular Register, spectral-domain optical coherence tomography (OCT) images and electronic patient charts. All eyes included were treated in the same clinical setting at the Department of Ophthalmology at the county hospital of Vastmanland in Vasteras, Sweden.

    Results In total, 282 and 359 eyes were included in the non-switch and switch cohorts, respectively. The cohorts were well balanced. Visual acuity remained stable during the observation period in both cohorts of eyes. The number of anti-VEGF treatments slowly declined over time in both cohorts of eyes and, consequently, the treatment intervals increased during the observation period. In eyes subjected to switch of anti-VEGF agent, planned treatment interval at 12 months was 7.6 (mean; SD 2.9) weeks compared to 6.8 (mean; SD 2.7) in the non-switch cohort (P = 0.001). OCT images demonstrated lower prevalence of intraretinal and subretinal fluid as well as pigment epithelial detachment at 12 months in eyes subjected to switch of anti-VEGF agent compared to non-switch eyes.

    Conclusion Switch of anti-VEGF agent from ranibizumab to aflibercept did not affect visual function whereas improvement in retinal morphology was observed. These findings suggest a beneficial effect of switching from ranibizumab to aflibercept in eyes with ongoing chronic anti-VEGF treatment irrespective of previous response to ranibizumab. Longer follow-up is required to further evaluate the potential clinical significance of this finding.

    Ladda ner fulltext (pdf)
    FULLTEXT01
  • 59.
    Granstam, Elisabet
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Reg Vastmanland, Ophthalmol, Västerås, Sweden..
    Krifors, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Karolinska Inst, Physiol & Pharmacol, Stockholm, Sweden..
    Freyhult, Elisabeth
    Reg Vastmanland, Clin Microbiol, Västerås, Sweden..
    Akerblom, Hanna
    Reg Vastmanland, Ophthalmol, Västerås, Sweden..
    No findings of SARS-CoV-2 in conjunctival swabs from patients at an emergency outpatient ophthalmological healthcare facility in a Swedish county hospital: a cross-sectional study2021Ingår i: BMJ Open Ophthalmology, E-ISSN 2397-3269, Vol. 6, nr 1, artikel-id e000616Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background COVID-19 is caused by SARS-CoV-2. Virus has been found in conjunctiva of hospitalised patients with COVID-19. Conjunctivitis has also been reported as a presenting symptom of disease.

    Objective The aims of the study were to investigate the prevalence of SARS-CoV-2 in the conjunctiva and throat among patients presenting at the emergency outpatient ophthalmological healthcare facility at a county hospital along with investigating the seroprevalence of SARS-CoV-2 among staff at the department.

    Methods and Analysis Swabs from conjunctiva and throat of patients were analysed with real-time reverse transcriptase PCR (RT-PCR) for SARS-CoV-2. Blood samples for serological analysis were obtained from staff. A questionnaire was used to investigate symptoms associated with COVID-19 during the last 3 months as well as symptoms for which the patients were seeking ophthalmological healthcare.

    Results In total, 68 patients and 70 individuals from the staff were included in the study. Conjunctivitis was observed in 7% of patients. One patient, presenting with reduced visual acuity due to preretinal haemorrhage in the macula, was positive for SARS-CoV-2 in throat swab. Contact tracing was negative. All other RT-PCR tests were negative. Seropositivity for SARS-CoV-2 was found in 4% of staff.

    Conclusions Our study demonstrated low prevalence of SARS-CoV-2 among patients as well as low seroprevalence of SARS-CoV-2 IgG-antibodies among staff at the ophthalmological ward. The risk for contracting COVID-19 at the department was small. Follow-up investigation is planned.

    Ladda ner fulltext (pdf)
    FULLTEXT01
  • 60.
    Granstam, Elisabet
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Vastmanland Cty Hosp Vasteras, Ophthalmol, Vasteras, Sweden..
    Sjovall, Kersti
    Vastmanland Cty Hosp Vasteras, Ophthalmol, Vasteras, Sweden..
    Paul, Anna
    Vastmanland Cty Hosp Vasteras, Ophthalmol, Vasteras, Sweden..
    Eriksson, Laila
    Vastmanland Cty Hosp Vasteras, Ophthalmol, Vasteras, Sweden..
    Change of treatment strategy for wet AMD from PRN to Treat-and-Extend: 6 months experience from a Swedish county hospital2015Ingår i: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 56, nr 7, artikel-id 5366Artikel i tidskrift (Refereegranskat)
  • 61.
    Granstam, Elisabet
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Västmanland City Hospital, Västeras.
    Sjovall, Kersti
    Västmanland City Hospital, Västeras.
    Paul, Anna
    Västmanland City Hospital, Västeras.
    Moren, Asa
    Västmanland City Hospital, Västeras.
    Anti VEGF-treatment for wet-AMD According to a Treat-and-Extend Protocol at a Swedish County Hospital: clinical outcomes at 12 Months2016Ingår i: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 57, nr 12Artikel i tidskrift (Refereegranskat)
  • 62.
    Granstam, Elisabet
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.
    Sjövall, Kersti
    Reg Vastmanland, Dept Ophthalmol, Västerås, Sweden..
    Rosen, Mats
    Reg Vastmanland, Dept Ophthalmol, Västerås, Sweden..
    Switch of anti-vascular growth factor agent from aflibercept to bevacizumab; outcomes in chronic wet age-related macular degeneration2022Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 100, nr 8, s. E1772-E1773Artikel i tidskrift (Övrigt vetenskapligt)
  • 63.
    Granstam, Elisabet
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
    Westborg, Inger
    Umea Univ, Dept Clin Sci Ophthalmol, Umea, Sweden..
    Barkander, Anna
    Ostersund Cty Hosp, Dept Ophthalmol, Ostersund, Sweden..
    Börjesson, Malin
    Skelleftea Cty Hosp, Dept Ophthalmol, Skelleftea, Sweden..
    Lindahl, Sara
    Umea Univ Hosp, Dept Ophthalmol, Umea, Sweden..
    Meszaros, Eva
    Gavleborg Cty Hosp Gavle, Dept Ophthalmol, Gavle, Sweden..
    Wojciechowska-Zajac, Anna
    Sunderby Cty Hosp, Dept Ophthalmol, Sunderbyn, Sweden..
    Wagner, Philippe
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
    Albrecht, Susanne
    RC Syd, Swedish Macula Register, Karlskrona, Sweden..
    Karlsson, Niklas
    RC Syd, Swedish Macula Register, Karlskrona, Sweden..
    Bjarnhall, Gunilla
    RC Syd, Swedish Macula Register, Karlskrona, Sweden..
    Lovestam-Adrian, Monica
    Lund Univ, IKVL Inst Clin Sci, Ophthalmol, Lund, Sweden..
    Reduced occurrence of severe visual impairment after introduction of anti-Vascular Endothelial Growth Factor in wet age-related macular degeneration: a population- and register-based study from northern Sweden2016Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 94, nr 7, s. 646-651Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PurposeTo study the occurrence of severe visual impairment (SVI) and treatment outcome at 12months in patients treated for wet age-related macular degeneration (AMD) by use of data from the Swedish Macula Register (SMR) and referrals to the regional low vision clinics in five northern counties. MethodsReferrals to low vision clinics during 2005, 2009 and 2013 and treatment outcome at 12months from the SMR database from 2008 until 2013 in patients >65years of age in five northern counties were included in the survey. ResultsThe rate of referral due to AMD was significantly reduced during the time period (-48%; p<0.001). At 12months, a significant slight mean improvement in logMAR visual acuity (VA) was observed (-0.01, SD 0.37; p<0.001) after a mean of 5.02.3 anti-vascular endothelial growth factor (VEGF)-injections were administered. Age and low baseline VA was associated with less favourable visual outcome (p<0.001). ConclusionReferral rate to low vision clinic is a valuable tool for estimating occurrence of SVI and fell between the years 2005 until 2013. Data from the SMR showed improvement in visual acuity on the whole, but also identified patients at high risk for developing SVI during anti-VEGF-treatment.

  • 64.
    Guenter, Alexander
    et al.
    Univ Tubingen, Inst Ophthalm Res, Div Ocular Neurodegenerat, D-72076 Tubingen, Germany..
    Sothilingam, Vithiyanjali
    Univ Tubingen, Inst Ophthalm Res, Div Ocular Neurodegenerat, D-72076 Tubingen, Germany..
    Orlich, Michael M.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    Nordheim, Alfred
    Univ Tubingen, Interfac Inst Cell Biol, Dept Mol Biol, D-72076 Tubingen, Germany..
    Seeliger, Mathias W.
    Univ Tubingen, Inst Ophthalm Res, Div Ocular Neurodegenerat, D-72076 Tubingen, Germany..
    Muehlfriedel, Regine
    Univ Tubingen, Inst Ophthalm Res, Div Ocular Neurodegenerat, D-72076 Tubingen, Germany..
    Mural Serum Response Factor (SRF) Deficiency Provides Insights into Retinal Vascular Functionality and Development2023Ingår i: International Journal of Molecular Sciences, ISSN 1661-6596, E-ISSN 1422-0067, Vol. 24, nr 16, artikel-id 12597Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Serum response factor (SRF) controls the expression of muscle contraction and motility genes in mural cells (MCs) of the vasculature. In the retina, MC-SRF is important for correct angiogenesis during development and the continuing maintenance of the vascular tone. The purpose of this study was to provide further insights into the effects of MC SRF deficiency on the vasculature and function of the mature retina in SrfiMCKO mice that carry a MC-specific deletion of Srf. Retinal morphology and vascular integrity were analyzed in vivo via scanning laser ophthalmoscopy (SLO), angiography, and optical coherence tomography (OCT). Retinal function was evaluated with full-field electroretinography (ERG). We found that retinal blood vessels of these mutants exhibited different degrees of morphological and functional alterations. With increasing severity, we found vascular bulging, the formation of arteriovenous (AV) anastomoses, and ultimately, a retinal detachment (RD). The associated irregular retinal blood pressure and flow distribution eventually induced hypoxia, indicated by a negative ERG waveform shape. Further, the high frequency of interocular differences in the phenotype of individual SrfiMCKO mice points to a secondary nature of these developments far downstream of the genetic defect and rather dependent on the local retinal context.

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  • 65. Gustavsson, Carina
    et al.
    Martinell, Mats
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Dorkhan, Mozhgan
    Diabetic retinopathy in All Newly diagnosed Diabetic subjects in Skane (ANDIS), Sweden, during 2008-2013. Baseline findings.2014Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 92, nr SI, s. 20-20Artikel i tidskrift (Övrigt vetenskapligt)
  • 66.
    Hao, Jie
    et al.
    Univ Basel, Univ Hosp Basel, Dept Biomed, Basel, Switzerland.;Capital Med Univ, Beijing Tongren Hosp, Beijing Inst Ophthalmol, Beijing, Peoples R China..
    Pircher, Achmed
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Söderberg: Oftalmiatrik. Kantonsspital Aarau, Dept Ophthalmol, Tellstr 25, CH-5001 Aarau, Switzerland..
    Miller, Neil R.
    Johns Hopkins Univ Hosp, Wilmer Ophthalmol Inst, Baltimore, MD 21287 USA..
    Hsieh, Jiemei
    Univ Basel, Univ Hosp Basel, Dept Ophthalmol, Basel, Switzerland..
    Remonda, Luca
    Kantonsspital Aarau, Dept Neuroradiol, Aarau, Switzerland..
    Killer, Hanspeter E.
    Univ Basel, Univ Hosp Basel, Dept Biomed, Basel, Switzerland.;Kantonsspital Aarau, Dept Ophthalmol, Tellstr 25, CH-5001 Aarau, Switzerland..
    Cerebrospinal fluid and optic nerve sheath compartment syndrome: A common pathophysiological mechanism in five different cases?2020Ingår i: Clinical and Experimental Ophthalmology, ISSN 1442-6404, E-ISSN 1442-9071, Vol. 48, nr 2, s. 212-219Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Importance Optic nerve (ON) dysfunction is a common feature of different diseases. The pathophysiology is not yet fully understood. Background This study describes five patients with ON sheath (ONS) compartment syndrome (ONSCS) and contributes to the hypothesis that impaired cerebrospinal fluid (CSF) flow can play a role in the development of ON dysfunction. Design Retrospective case series. Participants Five patients with ONSCS were included in the study. Methods Elaboration of medical histories and clinical and diagnostic findings over a long time period was carried out by analysing medical records and by a detailed medical consultation. Main Outcome Measures The main outcome measures include clinical history; visual acuity; field, intraocular and CSF pressures; and contrast-loaded computed tomographic (CT) cisternography. Results Compartmentation of the ONS demonstrated by contrast-loaded CT cisternography was the consistent finding in all five patients who demonstrated findings of ON dysfunction. The aetiologies varied and included meningitis, papilloedema, sphenoid wing meningioma, disc herniation and normal-tension glaucoma. Conclusion and Relevance Compartmentation of the ONS with consecutively impaired CSF dynamics within the ON subarachnoid space can lead to ON dysfunction. Different aetiologies can cause the development of ONSCS.

  • 67.
    Hao, Jie
    et al.
    Department of Biomedicine, University Hospital BaselUniversity of Basel Basel Switzerland;Beijing Institute of Ophthalmology, Beijing Tongren HospitalCapital Medical University Beijing China.
    Pircher, Achmed
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Department of Ophthalmology, Kantonsspital Aarau, Aarau, Switzerland.
    Miller, Neil R.
    Wilmer Ophthalmological InstituteJohns Hopkins Hospital Baltimore Maryland.
    Hsieh, Jiemei
    Department of Ophthalmology, University Hospital BaselUniversity of Basel Basel Switzerland.
    Remonda, Luca
    Department of NeuroradiologyKantonsspital Aarau Aarau Switzerland.
    Killer, Hanspeter E.
    Department of Biomedicine, University Hospital BaselUniversity of Basel Basel Switzerland;Department of OphthalmologyKantonsspital Aarau Aarau Switzerland.
    Cerebrospinal fluid and optic nerve sheath compartment syndrome: A common pathophysiological mechanism in five different cases?2019Ingår i: Clinical and Experimental Ophthalmology, ISSN 1442-6404, E-ISSN 1442-9071, Vol. 48, nr 2, s. 212-219Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Importance: Optic nerve (ON) dysfunction is a common feature of differentdiseases. The pathophysiology is not yet fully understood.

    Background: This study describes five patients with ON sheath (ONS) compartmentsyndrome (ONSCS) and contributes to the hypothesis that impairedcerebrospinal fluid (CSF) flow can play a role in the development of ONdysfunction.

    Design: Retrospective case series.

    Participants: Five patients with ONSCS were included in the study.

    Methods: Elaboration of medical histories and clinical and diagnostic findingsover a long time period was carried out by analysing medical records and by adetailed medical consultation.Main Outcome Measures: The main outcome measures include clinical history;visual acuity; field, intraocular and CSF pressures; and contrast-loadedcomputed tomographic (CT) cisternography.

    Results: Compartmentation of the ONS demonstrated by contrast-loadedCT cisternography was the consistent finding in all five patients whodemonstrated findings of ON dysfunction. The aetiologies varied and includedmeningitis, papilloedema, sphenoid wing meningioma, disc herniation andnormal-tension glaucoma.

    Conclusion and Relevance: Compartmentation of the ONS with consecutivelyimpaired CSF dynamics within the ON subarachnoid space can lead toON dysfunction. Different aetiologies can cause the development of ONSCS.

  • 68.
    Harun-Or-Rashid, Mohammad
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Medicinsk utvecklingsbiologi.
    Lindqvist, Niclas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Medicinsk utvecklingsbiologi.
    Hallböök, Finn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Medicinsk utvecklingsbiologi.
    Transactivation of EGF Receptors in Chicken Muller Cells by α2A-Adrenergic Receptors Stimulated by Brimonidine2014Ingår i: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 55, nr 6, s. 3385-3394Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: α2-Adrenergic receptor agonists are used in glaucoma treatment and have been shown to have some neuroprotective effects. We performed this study to test the hypothesis that epidermal growth factor receptors on chicken Müller cells are transactivated by α2-adrenergic receptors and we focused on the extracellular signal-activated kinases 1/2 (ERK) pathway. Methods: Embryonic chicken retina and cultures of primary Müller cells were stimulated by α2-adrenergic receptor agonist brimonidine. Immunostaining, qRT-PCR and western blot techniques in combination with Src-, epidermal growth factor receptor kinase-, and matrix metalloproteinase inhibitors were used for analysis of the cellular responses. Results: Our results showed that Müller cells express α2A-adrenergic receptors in vivo and in vitro and that brimonidine triggered a robust and transient phosphorylation of ERK1/2. This ERK-response was Src-kinase dependent, associated with tyrosine phosphorylation of epidermal growth factor receptors (phospho-Y1068, Y1173) and was mediated by matrix metalloproteinase-activity on the Müller cells. Conclusions: Müller cells express the α2A-adrenergic receptor and brimonidine triggers both Src-kinase- and matrix metalloproteinase-mediated autocrine ligand-dependent activation of epidermal growth factor receptors on Müller cell. This response is consistent with transactivation of epidermal growth factor receptors by stimulation of α2-adrenergic receptors.

  • 69.
    Hedin, Anders
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Oftalmiatrik.
    Ögonplastikkirurgi innebär ett återställande till det "normala"2000Ingår i: Läkartidningen, Vol. 97, nr 47, s. 5444-5450Artikel i tidskrift (Övrigt vetenskapligt)
  • 70.
    Hedman, Katarina
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
    Pooling Data from Similar Randomized Clinical Trials Comparing Latanoprost with Timolol; Medical Results and Statistical Aspects2003Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Two different principles were studied. 1st - statistical analysis techniques were used to obtain medical results from a patient population. 2nd - the patient population was used to study the statistical analysis techniques.

    Medical conclusions: latanoprost and timolol treatment showed a statistically significant and clinically useful mean IOP-reduction in a typical worldwide clinical trial population. Latanoprost reduced the IOP 1.6 mm Hg more than timolol. The IOP-reduction was maintained with timolol and slightly enforced with latanoprost up to 6 months of treatment. The mean IOP-reduction was maintained during 2 years of latanoprost treatment. The overall risk of withdrawal due to insufficient IOP-reduction with latanoprost was 8%.

    The statistical methodological issues are of a general and reoccurring character in trial design of the IOP-reduction: should the statistical hypothesis testing be based on the mean intraocular pressure (IOP) or the proportion of patients who reach a specific IOP level, should the estimate of the IOP or IOP-reduction be based on single eyes, mean of bilaterally eligible and identically treated eyes or the difference between an eye with active treatment and a placebo treated contralateral eye, and is mean of replicated recordings useful? Statistical methodological conclusions: the most effective response variable varies with the selected patient population. Therefore, the trial design process should include a comparison of the variability, test power and required sample size for the possible response variables in a sample of the target population. At minimum a statistical consideration should be done.

    Delarbeten
    1. A pooled data analysis of three randomised, double-masked six-month clinical studies comparing the intraocular pressure reducing effect of latanoprost and timolol
    Öppna denna publikation i ny flik eller fönster >>A pooled data analysis of three randomised, double-masked six-month clinical studies comparing the intraocular pressure reducing effect of latanoprost and timolol
    2000 (Engelska)Ingår i: European Journal of Ophthalmology, ISSN 1120-6721, E-ISSN 1724-6016, Vol. 10, nr 2, s. 95-104Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    PURPOSE:

    To compare the intraocular pressure (IOP) reduction by latanoprost and timolol, and to study factors of prognostic value for assessing this reduction.

    METHODS:

    We analyzed 829 patients included in three phase 111 studies comparing six months' treatment with 0.005% latanoprost once daily and 0.5% timolol twice daily in patients with open-angle glaucoma or ocular hypertension. Analysis of covariance controlled for differences in baseline IOP and sex was used to assess the IOP reduction.

    RESULTS:

    Latanoprost reduced diurnal IOP (average of morning, noon and afternoon assessments) by 7.7 mmHg (31%) and timolol by 6.5 mmHg (26%) after six months of treatment. Thus the diurnal IOP was reduced 1.2 mmHg (18%) more with latanoprost than with timolol (p<0.001). Latanoprost-treated patients showed a further decrease in morning IOP of 0.7 mmHg (9%, p<0.001) from the initial morning IOP reduction obtained at two weeks. No such further decrease in IOP was seen with timolol. Higher baseline diurnal IOP resulted in a larger diurnal reduction during treatment with both drugs (p<0.001). Diurnal IOP in women was reduced 0.7 mmHg (11%) less than males with both drugs (p<0.001).

    CONCLUSIONS:

    Latanoprost was more effective than timolol in reducing mean diurnal IOP. The effect after two weeks was maintained for timolol while with latanoprost there was a further, significant IOP reduction from two weeks to six months. Baseline IOP was the only factor of clinical importance found to be of prognostic value for assessing the IOP reduction.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:uu:diva-90322 (URN)10887918 (PubMedID)
    Tillgänglig från: 2003-04-07 Skapad: 2003-04-07 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
    2. The effect of latanoprost compared with timolol in African-American, Asian, European, Mexican and US glaucoma or ocular hypertensive patients
    Öppna denna publikation i ny flik eller fönster >>The effect of latanoprost compared with timolol in African-American, Asian, European, Mexican and US glaucoma or ocular hypertensive patients
    2002 (Engelska)Ingår i: Survey of ophthalmology, ISSN 0039-6257, E-ISSN 1879-3304, Vol. 47, nr 4S1, s. 77-89Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    OBJECTIVE:

    To study the intraocular pressure (IOP) reduction of latanoprost or timolol in a heterogeneous global population.

    METHODS:

    A total of 1,389 glaucoma or ocular hypertensive patients treated with 0.005% latanoprost once daily (n = 737) or 0.5% timolol twice daily (n = 652) from eight clinical trials were included. After 3-6 months of treatment, the IOP was analyzed with use of analysis of covariance.

    RESULTS:

    Latanoprost or timolol gave statistically significant mean diurnal IOP reduction in the African-American, Asian, Caucasian, and Mexican patients, latanoprost with 7.9 mm Hg and timolol with 6.4 mm Hg. The Asian and Mexican patients showed a larger difference in mean diurnal IOP reduction with use of the two drugs (range 1.8-3.1 mm Hg) than the European and U.S. patients (range 0.6-1.7 mm Hg, p = 0.030). Latanoprost produced similar mean diurnal IOP reduction in patients with and without previous glaucoma treatment other than prostaglandins.

    CONCLUSION:

    Latanoprost or timolol statistically significantly reduced the mean diurnal IOP in a heterogenous global population in eight clinical trials. The degree of reduction appeared to be clinically useful. The greatest difference in the mean diurnal IOP-lowering effect of latanoprost or timolol was observed in Mexican and Asian clinical trials.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:uu:diva-90323 (URN)10.1016/S0039-6257(02)00310-7, (DOI)12204703 (PubMedID)
    Tillgänglig från: 2003-04-07 Skapad: 2003-04-07 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
    3. The Effect of Latanoprost on Intraocular Pressure During 2 Years of Treatment
    Öppna denna publikation i ny flik eller fönster >>The Effect of Latanoprost on Intraocular Pressure During 2 Years of Treatment
    2002 (Engelska)Ingår i: Survey of ophthalmology, ISSN 0039-6257, E-ISSN 1879-3304, Vol. 47, nr S1, s. 65-76Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Our objective was to study the intraocular pressure (IOP) in open-angle glaucoma or ocular hypertensive patients during long-term treatment with latanoprost. A total of 532 patients treated with 0.005% latanoprost were enrolled, including 493 and 113 patients treated for 6 and 24 months, respectively. Mean IOP was analyzed with the analysis of variance technique. The risk of treatment failure was analyzed with survival analysis technique. After 2 weeks of latanoprost treatment, the mean IOP was reduced 8.2 (32%) and 8.9 (34%) mm Hg in the subgroups of patients treated for 6 and 24 months, respectively. The change in mean IOP during 2 years of latanoprost treatment was not statistically significant (p = 0.15). Patients with primary open-angle glaucoma or ocular hypertension showed an 86% and 97% chance of receiving a sufficient IOP reduction with latanoprost (p < 0.01), repectively. The initial mean IOP reduction was maintained throughout the 2 years of treatment.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:uu:diva-90324 (URN)10.1016/S0039-6257(02)00301-6 (DOI)12204702 (PubMedID)
    Tillgänglig från: 2003-04-07 Skapad: 2003-04-07 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
    4. Which endpoint: mean intraocular pressure or proportion of successful patients?
    Öppna denna publikation i ny flik eller fönster >>Which endpoint: mean intraocular pressure or proportion of successful patients?
    2003 (Engelska)Ingår i: Journal of glaucoma, ISSN 1057-0829, E-ISSN 1536-481X, Vol. 12, nr 4, s. 321-332Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    A reduction in intraocular pressure in clinical trials can be determined through the mean intraocular pressure, through the proportion of patients who have the intraocular pressure reduced to a specific target intraocular pressure, or both. Since both these possible endpoints measure the shift of 2 intraocular pressure distributions, we recommend that only one of them be tested. In general, testing the difference between mean-values is much more efficient than testing the difference between proportions. However, proportions of successful patients are valuable in showing the clinical implication of a reduction in mean intraocular pressure, particularly when evaluating a moderate pressure reduction. The effect of a small mean intraocular pressure reduction on the probability to reach the target intraocular pressure is pointed out, particularly the fact that it can be substantial even if the mean reduction is smaller than the measurement error.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:uu:diva-90325 (URN)12897577 (PubMedID)
    Tillgänglig från: 2003-04-07 Skapad: 2003-04-07 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
    5. Estimating mean intraocular pressure of a group of patients; lessons learned by analyzing clinical trials of open-angle or ocular hypertensive patients
    Öppna denna publikation i ny flik eller fönster >>Estimating mean intraocular pressure of a group of patients; lessons learned by analyzing clinical trials of open-angle or ocular hypertensive patients
    Ingår i: Journal of GlaucomaArtikel i tidskrift (Refereegranskat) Submitted
    Identifikatorer
    urn:nbn:se:uu:diva-90326 (URN)
    Tillgänglig från: 2003-04-07 Skapad: 2003-04-07Bibliografiskt granskad
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  • 71.
    Hellgren, Kerstin M.
    et al.
    Astrid Lindgren Childrens Hosp, Dept Clin Neurosci, Karolinska Inst, MBC, Polhemsgatan 56, S-11282 Stockholm, Sweden..
    Tornqvist, Kristina
    Univ Lund Hosp, Dept Ophthalmol, S-22185 Lund, Sweden..
    Jakobsson, Peter G.
    Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden..
    Lundgren, Pia
    Umea Univ, Dept Ophthalmol, S-90187 Umea, Sweden..
    Carlsson, Birgitta
    Univ Orebro, Dept Ophthalmol, SE-70182 Orebro, Sweden..
    Kallen, Karin
    Lund Univ, Dept Obstet & Gynecol, Ctr Reprod Epidemiol, Lund, Sweden..
    Serenius, Fredrik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik.
    Hellstrom, Ann
    Univ Gothenburg, Sahlgrenska Acad, Sect Pediat Ophthalmol, Gothenburg, Sweden..
    Holmström, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Ophthalmologic Outcome of Extremely Preterm Infants at 6.5 Years of Age Extremely Preterm Infants in Sweden Study (EXPRESS)2016Ingår i: JAMA ophthalmology, ISSN 2168-6165, E-ISSN 2168-6173, Vol. 134, nr 5, s. 555-562Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    IMPORTANCE This follow-up study of extremely preterm (EPT) children (<27 weeks' gestational age [GA] at birth) revealed major eye and visual problems in 37.9%(147 of 388) of all EPT infants and in 55.4%(67 of 121) of the most immature subgroups at 6.5 years of age. These major eye and visual problems were strongly associated with treatment-requiring retinopathy of prematurity (ROP). OBJECTIVES To investigate the ophthalmologic outcome of a national cohort of EPT children at 6.5 years of age and to evaluate the impact of prematurity and ROP. DESIGN, SETTING, AND PARTICIPANTS All surviving EPT children born in Sweden between April 1, 2004, and March 31, 2007, were included and compared with a matched term control group, as part of a prospective national follow-up study. MAIN OUTCOMES AND MEASURES Visual acuity, refraction in cycloplegia, and manifest strabismus were evaluated and compared with GA at birth and with treatment-requiring ROP. RESULTS The study cohort comprised 486 participants. The mean (SD) GA of the children who were included was 25 (1) weeks, and 45.7%(222 of 486) were female. At a median age of 6.6 years, 89.3%(434 of 486) of eligible EPT children were assessed and compared with 300 control group children. In the EPT group, 2.1%(9 of 434) were blind, 4.8%(21 of 434) were visually impaired according to the World Health Organization criteria, and 8.8% (38 of 434) were visually impaired according to the study criteria. Strabismus was found in 17.4% (68 of 390) and refractive errors in 29.7%(115 of 387) of the EPT children compared with 0% (0 of 299) and 5.9% (17 of 289), respectively, of the control children (P<.001). Altogether at 6.5 years of age, 37.9%(147 of 388) of the EPT children had some ophthalmologic abnormality compared with 6.2%(18 of 290) of the matched control group (95% CI of the difference, 26.1%-37.2%). When treatment-requiring ROP was adjusted for, no significant association between GA and visual impairment could be detected. For refractive errors, the association with GA remained after adjustment for treatment-requiring ROP (odds ratio, 0.72; 95% CI, 0.58-0.91 for each 1-week increment). CONCLUSIONS AND RELEVANCE In a Swedish national cohort of EPT children at 6.5 years of age, major eye and visual problems were frequently found. Treatment-requiring ROP was a stronger impact factor than GA on visual impairment and strabismus, but not on refractive errors, as a whole. In modern neonatal intensive care settings, ophthalmologic problems continue to account for a high proportion of long-term sequelae of prematurity.

  • 72.
    Hellstrom, Ann
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Sahlgrenska Ctr Pediat Ophthalmol Res,Dept Clin N, Gothenburg, Sweden..
    Jacobson, Lena
    Karolinska Inst, Dept Clin Neurosci, Sect Eye & Vis, Stockholm, Sweden.;Karolinska Univ Sjukhuset, Astrid Lindgren Childrens Hosp, Neuropediat Dept, Stockholm, Sweden..
    Al-Hawasi, Abbas
    Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden..
    Hellström-Westas, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Rakow, Alexander
    Karolinska Inst, Dept Woman & Child Hlth, Stockholm, Sweden..
    Johnson, Mats
    Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden..
    Savman, Karin
    Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, Dept Neonatol, Reg Vastra Gotland, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden..
    Holmström, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Larsson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Granse, Lotta
    Skane Univ Hosp Lund, Dept Clin Sci, Ophthalmol, Lund, Sweden..
    Saric, Marie
    Umeå Univ, Med Fak, Dept Clin Sci, Ophthalmol, Umeå, Sweden..
    Sunnqvist, Birgitta
    Lanssjukhuset Ryhov, Dept Ophthalmol, Jönköping, Sweden..
    Smith, Lois
    Harvard Med Sch, Boston Childrens Hosp, Dept Ophthalmol, Boston, MA 02115 USA..
    Hard, Anna-Lena
    Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Sahlgrenska Ctr Pediat Ophthalmol Res,Dept Clin N, Gothenburg, Sweden..
    Morsing, Eva
    Skane Univ Hosp Lund, Dept Pediat, Clin Sci, Lund, Sweden..
    Lundgren, Pia
    Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Sahlgrenska Ctr Pediat Ophthalmol Res,Dept Clin N, Gothenburg, Sweden..
    Retrospective evaluation of ophthalmological and neurological outcomes for infants born before 24 weeks gestational age in a Swedish cohort2022Ingår i: BMJ Open, E-ISSN 2044-6055, Vol. 12, nr 8, artikel-id e055567Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objectives To retrospectively evaluate ophthalmological and neurological outcomes in a Swedish cohort of infants born before 24 weeks gestational age (GA) and explore risk factors for visual impairment. Setting Eye and paediatric clinics in Sweden. Participants Infants screened for retinopathy of prematurity (ROP) (n=399), born before 24 weeks GA, 2007-2018. Cases were excluded if ophthalmological follow-up records could not be traced. Primary and secondary outcome measures Primary outcomes were ophthalmological, including visual acuity (VA), refractive error, strabismus, nystagmus and cerebral visual impairment (CVI). Secondary outcomes comprised neonatal and neurological morbidities. Data were retrospectively retrieved from medical records. Results The 355 assessed children had a median GA of 23 weeks and 2 days and a median birth weight of 565 g. At the last available ophthalmological examination, the median age was 4.8 years (range 0.5-13.2 years). Nystagmus was recorded in 21.1%, strabismus in 34.8%, and 51.0% wore spectacles. Seventy-three of 333 (21.9%) were visually impaired, defined as being referred to a low vision clinic and/or having a VA less than 20/60 at 3.5 years of age or older. ROP treatment was a significant risk factor for visual impairment (OR 2.244, p=0.003). Visually impaired children, compared with children without visual impairment, more often had neurological deficits such as intellectual disability 63.8% versus 33.3% (p<0.001), epilepsy 21.1% versus 7.5% (p=0.001) and autism spectrum disorders 32.8% versus 20.9% (p=0.043). Nine of the 355 children had been diagnosed with CVI. Conclusions Children born before 24 weeks GA frequently had visual impairment in association with neurological deficits. CVI was rarely diagnosed. A multidisciplinary approach for the evaluation and habilitation of these vulnerable infants is warranted. National follow-up guidelines need to be developed and implemented.

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  • 73.
    Hellström, Ann
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Sect Pediat Ophthalmol, Gothenburg, Sweden.
    Källen, Karin
    Lund Univ, Ctr Reprod Epidemiol, Lund, Sweden.
    Carlsson, Birgitta
    Örebro Univ, Dept Ophthalmol, Örebro, Sweden.
    Holmström, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Jakobsson, Peter
    Linköping Univ, Dept Clin & Expt Med, Linköping, Sweden.
    Lundgren, Pia
    Umeå Univ, Dept Clin Sci, Ophthalmol, Umeå, Sweden.
    Serenius, Fredrik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Perinatal, neonatal och barnkardiologisk forskning.
    Stjernqvist, Karin
    Lund Univ, Dept Psychol, Lund, Sweden.
    Tornqvist, Kristina
    Lund Univ Hosp, Dept Ophthalmol, Lund, Sweden.
    Hellgren, Kerstin
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
    Extreme prematurity, treated retinopathy, bronchopulmonary dysplasia and cerebral palsy are significant risk factors for ophthalmological abnormalities at 6.5 years of age2018Ingår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, nr 5, s. 811-821Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Aim: This study evaluated the contributions of various prenatal and postnatal predictive factors to a documented high prevalence of ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm.

    Methods: We carried out a prospective population‐based study of all children born in Sweden at a gestational age of 22 + 0 to 26 + 6 weeks based on the Extremely Preterm Infants in Sweden Study. The main outcome measures were a combined score of visual impairment, refractive errors and strabismus at 6.5 years of age. Models of univariate and multivariable regression were used to analyse potential prenatal and postnatal predictive factors at different clinically relevant time‐points from one minute after birth to 30 months.

    Results: We focused on 399 known extremely preterm survivors and compared them to 300 full‐term controls. Significant antecedents for ophthalmological abnormalities included prematurity per se, retinopathy of prematurity that required treatment, severe bronchopulmonary dysplasia and cerebral palsy. Severe intraventricular haemorrhage was no longer a significant risk factor when we adjusted it for the 30‐month cognitive and neuromotor development outcomes.

    Conclusion: This time‐course risk analysis model showed a changing panorama of significant risk factors for ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm.

  • 74.
    Holmström, Gerd
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Oftalmiatrik.
    Horner's syndrome: an atypical presentation in a child with neurofibromatosis type 22006Ingår i: Eye, Vol. 20, s. 1472-1474Artikel i tidskrift (Refereegranskat)
  • 75.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Eriksson, Urban
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Hellgren, Kerstin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Larsson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Optical coherence tomography is helpful in the diagnosis of foveal hypoplasia2010Ingår i: Acta Ophthalmologica, ISSN 1755-375X, Vol. 88, nr 4, s. 439-442Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: To investigate whether optical coherence tomography (OCT) is helpful in the diagnosis of foveal hypoplasia in children. Methods: Children with albinism and aniridia were examined with Stratus OCT 3 software 4.0.1 (Carl Zeiss Meditec, Dublin, California, USA). A qualitative examination of the macular area was performed with a 128 A-scans/second-single-scan. Macular thickness was measured quantitatively with an automatic fast macular map protocol. The average thickness/volume of the macula was presented as numerical values and as a false colour code in nine modified early treatment of diabetic retinopathy study (ETDRS) areas (A1-A9). A previously collected control group of children was used for comparison. Results: Macular thickness in 13 children with albinism and three children with aniridia was measured with OCT. Comparison with healthy children in the same population was performed. Patients with albinism and aniridia had significantly thicker central macula (A1) and foveola than children in the control group. Conclusion: OCT was found to be useful in the diagnosis of foveal hypoplasia in children.

  • 76.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Hellstrom, A.
    Univ Gothenburg, Sahlgrenska Acad, Queen Silvia Childrens Hosp, Sect Pediat Ophthalmol, Gothenburg, Sweden..
    Jakobsson, P.
    Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden..
    Lundgren, P.
    Umea Univ, Dept Clin Sci & Ophthalmol, Umea, Sweden..
    Tornqvist, K.
    Univ Lund Hosp, Dept Ophthalmol, Lund, Sweden..
    Wallin, A.
    St Erik Eye Hosp, Stockholm, Sweden..
    Screening for retinopathy of prematurity can be started in postmenstrual week 31 in very premature babies!2016Ingår i: Eye (London. 1987), ISSN 0950-222X, E-ISSN 1476-5454, Vol. 30, nr 11, s. 1524-1525Artikel i tidskrift (Refereegranskat)
  • 77.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Hellström, Ann
    Jakobsson, Peter
    Lundgren, Pia
    Tornqvist, Kristina
    Wallin, Agneta
    Evaluation of new guidelines for ROP screening in Sweden using SWEDROP - a national quality register2015Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 93, nr 3, s. 265-268Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PurposeTo investigate whether recent Swedish guidelines for Retinopathy of Prematurity (ROP) screening, that is, a gestational age (GA) at birth of <31weeks (w), are applicable in a new national cohort of prematurely born infants. MethodsSWEDROP is a national register for ROP, initiated in 2006. The present paper reports on data from the register on various aspects of screening for ROP in infants born between 2010 and 2011 and compares the results with those for a previously published cohort born between 2008 and 2009. ResultsDuring the study period, 1744 infants were screened for ROP. Mean GA was 28.4w (22-31), and mean birth weight was 1239g (382-2615). Screening started at postnatal age (PNA) 5.4w (0.4-13.3) and postmenstrual age (PMA) 33.8 w (24.9-50.1) Mean number of examinations was 5.4 per infant (1-38). Mild (stages 1-2) and severe ( stage 3) ROP was found in 15.4% and 8.7%, respectively. Treatment was performed in 4.2% (73/1744) of the infants, but in none with a GA of 30weeks or more. The first treatment was performed at a mean PNA and PMA of 12.7 w (7.7-25.4) and 37.4 w (32.1-51.4), respectively. ConclusionsRecently introduced new guidelines for ROP screening in Sweden remain applicable. Reassuringly, in infants born between 2010 and 2011, incidence of ROP, frequency and timing of treatment, frequency and timing of examinations and national coverage of ROP screening remained almost identical to those for a previous cohort from 2008 to 2009. The two SWEDROP cohorts provide a basis for discussion among Swedish ophthalmologists and neonatologists on the question of further lowering the upper screening limit with 1week.

  • 78.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Hellström, Ann
    Univ Gothenburg, Sahlgrenska Acad, Queen Silvia Childrens Hosp, Sect Pediat Ophthalmol, Gothenburg, Sweden..
    Jakobsson, Peter
    Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden..
    Lundgren, Pia
    Umea Univ, Ophthalmol, Dept Clin Sci, Umea, Sweden..
    Tornqvist, Kristina
    Univ Lund Hosp, Dept Ophthalmol, Lund, Sweden..
    Wallin, Agneta
    St Erik Eye Hosp, Stockholm, Sweden..
    Five years of treatment for retinopathy of prematurity in Sweden: results from SWEDROP, a national quality register2016Ingår i: British Journal of Ophthalmology, ISSN 0007-1161, E-ISSN 1468-2079, Vol. 100, nr 12, s. 1656-1661Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background/aims Retinopathy of prematurity (ROP) is a sight-threatening disease, requiring efficient screening and treatment. The present study aims to describe various aspects on treatment for ROP in Sweden. Methods Data on treatment for ROP in infants born in 2008-2012 were extracted from Swedish national register for retinopathy of prematurity, a web-based national register. Results During 2008-2012, 3488 infants with a gestational age (GA) at birth of <31 weeks had been screened for ROP in Sweden. Altogether, 30.3% (1057/3488) of the infants developed ROP and 5.2% (181/3488) were treated. Type 1 ROP was found in at least one eye in 83.2% (149/179) of the treated infants. One third of the eyes (32.2% right, 29.9% left eyes) were treated more than once. Laser was the only treatment in 90% of the eyes. Mean number of laser spots at first laser session was 1177 and 1386 in right and left eyes, respectively. Number of laser spots correlated negatively with GA at birth (p=0.01). There was no change in frequency of treatment or number of laser spots during the 5-year period. Anti-vascular endothelial growth factor injections were performed in 28 eyes, encircling band was used in five eyes and vitrectomies were performed in seven eyes. Twenty-six retinal surgeons performed 9.4 (range 1-37) treatment sessions in the 181 infants. Conclusions The present study reveals similar incidences of ROP and frequencies of treatment during the 5-year study period. Many surgeons were involved in treatment of a rather limited number of infants. The results call for national discussions on organisation of ROP treatment.

  • 79.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik. Department of Surgical Sciences, Ophthalmology Uppsala University Uppsala Sweden.
    Hellström, Ann
    Department of Clinical Neuroscience, Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden.
    Teär Fahnehjelm, Kristina
    Department of Clinical Neuroscience, Section for Eye and Vision Karolinska Institutet Stockholm Sweden;St. Erik Eye Hospital Stockholm Sweden.
    Gränse, Lotta
    Department of Clinical Sciences, Ophthalmology Skane University Hospital, Lund University Lund Sweden.
    Sandgren Hochhard, Karin
    Department of Clinical Sciences, Ophthalmology Umeå University Umeå Sweden.
    Sunnqvist, Birgitta
    Länssjukhuset Ryhov Jönköping Sweden.
    Tornqvist, Kristina
    Department of Clinical Sciences, Ophthalmology Skane University Hospital, Lund University Lund Sweden.
    Tsamadou, Despoina
    Department of Ophthalmology University Hospital, Örebro University Örebro Sweden.
    Wallin, Agneta
    St. Erik Eye Hospital Stockholm Sweden.
    Larsson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik. Department of Surgical Sciences, Ophthalmology Uppsala University Uppsala Sweden.
    Treatment for retinopathy of prematurity in Sweden 2008–2021: Reduced gestational age of treated infants and remaining differences in treatment type and recurrence rates between hospitals2023Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768Artikel i tidskrift (Refereegranskat)
  • 80.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik. Department of Surgical Sciences, Ophthalmology Uppsala University Uppsala Sweden.
    Hellström, Ann
    Department of Clinical Neuroscience, Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden.
    Teär Fahnehjelm, Kristina
    Department of Clinical Neuroscience, Section for Eye and Vision Karolinska Institutet Stockholm Sweden;St. Erik Eye Hospital Stockholm Sweden.
    Gränse, Lotta
    Department of Clinical Sciences, Ophthalmology Skane University Hospital, Lund University Lund Sweden.
    Sandgren Hochhard, Karin
    Department of Clinical Sciences, Ophthalmology Umeå University Umeå Sweden.
    Sunnqvist, Birgitta
    Länssjukhuset Ryhov Jönköping Sweden.
    Tornqvist, Kristina
    Department of Clinical Sciences, Ophthalmology Skane University Hospital, Lund University Lund Sweden.
    Tsamadou, Despoina
    Department of Ophthalmology University Hospital, Örebro University Örebro Sweden.
    Wallin, Agneta
    St. Erik Eye Hospital Stockholm Sweden.
    Larsson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik. Department of Surgical Sciences, Ophthalmology Uppsala University Uppsala Sweden.
    Treatment for retinopathy of prematurity in Sweden 2008–2021: Reduced gestational age of treated infants and remaining differences in treatment type and recurrence rates between hospitals2023Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768Artikel i tidskrift (Refereegranskat)
  • 81.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Oftalmiatrik.
    Larsson, Eva
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Oftalmiatrik.
    Development of Spherical Equivalent Refraction in Prematurely Born Children During the First 10 Years of Life: A Population-Based Study2005Ingår i: Arch Ophthalmol, Vol. 123, nr 10, s. 1404-1411Artikel i tidskrift (Refereegranskat)
  • 82.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. oftalmiatrik.
    Larsson, Eva
    Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. oftalmiatrik.
    Long-term follow-up of visual functions in prematurely born children - a prospective population-based study up to 10 years of age.2008Ingår i: Journal of AAPOS, Vol. 12, nr 2, s. 157-162Artikel i tidskrift (Refereegranskat)
  • 83.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Larsson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Outcome of Retinopathy of Prematurity2013Ingår i: Clinics of Perinatology, ISSN 0095-5108, E-ISSN 1557-9840, Vol. 40, nr 2, s. 311-321Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In prematurely born children, various visual and ophthalmologic sequelae occur because of both retinopathy of prematurity (ROP) and preterm birth per se. Several long-term follow-up studies have described the outcome of ROP. Visual impairment and blindness are well-known consequences, but the prevalence varies globally because of differing neonatal and ophthalmologic care. Improving treatment options and criteria for the treatment of ROP are continuously changing the ophthalmologic outcome. The anatomic outcome has improved with treatment, but good anatomic outcome in treated severe ROP does not always reflect the functional outcome. There is no consensus regarding long-term follow-up of prematurely born children.

  • 84.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Larsson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Ögonsjukdomar2011Ingår i: Pediatrik / [ed] Christian Moëll, Jan Gustafsson, Stockholm: Liber, 2011, 1, s. 527-535Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • 85.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
    Marie-Louise, Bondeson
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik.
    Eriksson, Urban
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Åkerblom, Hanna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Larsson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    'Congenital' nystagmus may hide various ophthalmic diagnoses2014Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 92, nr 5, s. 412-416Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose

    To investigate whether patients registered at a low-vision centre with ‘nystagmus’ had any underlying, but so far unknown, ophthalmic diagnosis.

    Methods

    All patients registered at the low-vision centre of Uppsala county with nystagmus as their major diagnosis were identified. Their medical records were studied to exclude those with other general diagnoses that could explain the nystagmus. The remaining group of patients underwent an ophthalmic examination, refraction and optical coherence tomography (OCT). Electroretinogram and genetic analyses were performed when indicated.

    Results

    Sixty-two patients with nystagmus as their main diagnosis were registered at the low-vision centre, Uppsala, and 43 of them had a major diagnosis other than nystagmus. Nystagmus was the major diagnosis in 19 patients, 15 of whom, aged 6–76 years, participated in the study. Two of the patients had foveal hypoplasia and albinism, four a seemingly isolated foveal hypoplasia, three achromatopsia, one rod-cone dystrophy, one degenerative high myopia, and two could not be evaluated. Only two patients appeared to have ‘congenital’ nystagmus. Eleven of the patients underwent a comprehensive genetic investigation of the PAX 6 gene. In addition, four of the patients were analysed for mutations in FOXC1 and PITX2 and one in FRMD7. No mutations were found in any of the patients analysed.

    Conclusion

    The study illustrates that many patients in our study group with nystagmus had underlying ophthalmic diagnoses. Early diagnosis is important to facilitate habilitation and to provide genetic counselling and, in the future, possibly also gene therapy.

  • 86.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Rydberg, Agneta
    Larsson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Prevalence and Development of Strabismus in 10-Year-Old Premature Children: A population-based study2006Ingår i: Journal of pediatric ophthalmology and strabismus, ISSN 0191-3913, E-ISSN 1938-2405, Vol. 43, nr 6, s. 346-352Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: To evaluate the prevalence and development of strabismus, at 10 years, in children born prematurely. Methods: This population-based study included 216 premature and 217 full-term children from the same geographic area. Results: Strabismus was noted in 16.2% (35 of 216) premature and in 3.2% (7 of 217) full-term children. The most important risk factors for strabismus at 10 years were anisometropia at 6 months, spherical equivalent refractive errors (ie, > +3 D or < -3 D) at 2.5 years, and various neurologic conditions. Conclusion: At 10 years, children born prematurely have a greater risk of strabismus than children born at term.

  • 87.
    Holmström, Gerd
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Tornqvist, Kristina
    Lund Univ, Skane Univ Hosp, Dept Clin Sci, Ophthalmol, Lund, Sweden..
    Al-Hawasi, Abbas
    Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden..
    Nilsson, Åsa
    Umea Univ, Dept Clin Sci, Ophthalmol, Umea, Sweden..
    Wallin, Agneta
    St Erik Eye Hosp, Stockholm, Sweden..
    Hellström, Ann
    Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Dept Clin Neurosci & Rehabil,Sect Ophthalmol, Gothenburg, Sweden..
    Increased frequency of retinopathy of prematurity over the last decade and significant regional differences2018Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 96, nr 2, s. 142-148Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: Retinopathy of prematurity (ROP) causes childhood blindness globally in prematurely born infants. Although increased levels of oxygen supply lead to increased survival and reduced frequency of cerebral palsy, increased incidence of ROP is reported.

    Methods: With the help of a Swedish register for ROP, SWEDROP, national and regional incidences of ROP and frequencies of treatment were evaluated from 2008 to 2015 (n=5734), as well as before and after targets of provided oxygen changed from 85-89% to 91-95% in 2014.

    Results: Retinopathy of prematurity (ROP) was found in 31.9% (1829/5734) of all infants with a gestational age (GA) of <31weeks at birth and 5.7% of the infants (329/5734) had been treated for ROP. Analyses of the national data revealed an increased incidence of ROP during the 8-year study period (p=0.003), but there was no significant increase in the frequency of treatment. There were significant differences between the seven health regions of Sweden, regarding both incidence of ROP and frequency of treatment (p<0.001). Comparison of regional data before and after the new oxygen targets revealed a significant increase in treated ROP in one region [OR: 2.24 (CI: 1.11-4.49), p=0.024] and a borderline increase in one other [OR: 3.08 (CI: 0.99-9.60), p=0.052].

    Conclusion: The Swedish national ROP register revealed an increased incidence of ROP during an 8-year period and significant regional differences regarding the incidence of ROP and frequency of treatment.

  • 88.
    Hreinsdottir, Jonina
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Kaul, Ylva Fredriksson
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Perinatal, neonatal och barnkardiologisk forskning.
    Hellström-Westas, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Perinatal, neonatal och barnkardiologisk forskning.
    Rosander, Kerstin
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    von Hofsten, Claes
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Holmström, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Impaired cognitive ability at 2.5 years predicts later visual and ophthalmological problems in children born very preterm2018Ingår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, nr 5, s. 822-830Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Aim: To identify possible predictive factors for visual problems at 6.5 years in children born very preterm.

    Methods: During 2004–2007, all very preterm infants (gestational age [GA] <32 weeks) in Uppsala County, Sweden were screened for retinopathy of prematurity (ROP) neonatally; at four months, visual tracking was tested; at 2.5 years, visuospatial and cognitive tests were carried out. At 6.5 years, 84 preterm children and a reference group of 64 full‐term children underwent ophthalmological testing.

    Results: Mean visual acuity (VA) did not differ between the groups, but subnormal VA (≤0.8) was more common in the preterm group (31% vs 14%; p < 0.05). More often than full‐term children, preterm children had impaired contrast sensitivity (<0.5) (36% vs 19%; p < 0.05) and strabismus (8% vs 0%; p < 0.05). Low GA, ROP, intraventricular haemorrhage 3‐4/periventricular leukomalacia and cognitive disability at 2.5 years predicted ophthalmological and visual problems at 6.5 years. Visual tracking ability at four months was not predictive of ophthalmological outcome.

    Conclusion: Children born preterm had more ophthalmological problems at 6.5 years of age, including subtle dysfunctions. ROP, early brain injury and impaired cognitive function around 2.5 years predicted later ophthalmological dysfunctions.

  • 89.
    Huang-Link, Yumin
    et al.
    Linköping Univ, Dept Biomed & Clin Sci, Div Neurol, S-58185 Linköping, Sweden..
    Yang, Ge
    Sun Yat sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510275, Peoples R China..
    Gustafsson, Greta
    Linköping Univ, Dept Biomed & Clin Sci, Div Neurophysiol, S-58185 Linköping, Sweden..
    Gauffin, Helena
    Linköping Univ, Dept Biomed & Clin Sci, Div Neurol, S-58185 Linköping, Sweden..
    Landtblom, Anne-Marie
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Neurologi. Linköping Univ, Dept Biomed & Clin Sci, Div Neurol, S-58185 Linköping, Sweden..
    Mirabelli, Pierfrancesco
    Linköping Univ, Dept Biomed & Clin Sci, Div Ophthalmol, S-58185 Linköping, Sweden..
    Link, Hans
    Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden..
    The Importance of Optical Coherence Tomography in the Diagnosis of Atypical or Subclinical Optic Neuritis: A Case Series Study2023Ingår i: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 12, nr 4, artikel-id 1309Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Optic neuritis (ON) is an inflammatory condition of the optic nerve. ON is associated with development of demyelinating diseases of the central nervous system (CNS). CNS lesions visualized by magnetic resonance imaging (MRI) and the finding of oligoclonal IgG bands (OB) in the cerebrospinal fluid (CSF) are used to stratify the risk of MS after a "first" episode of ON. However, the diagnosis of ON in absence of typical clinical manifestations can be challenging. Methods and Materials: Here we present three cases with changes in the optic nerve and ganglion cell layer in the retina over the disease course. (1) A 34-year-old female with a history of migraine and hypertension had suspect amaurosis fugax (transient vision loss) in the right eye. This patient developed MS four years later. Optical coherence tomography (OCT) showed dynamic changes of the thickness of peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) over time. (2) A 29-year-old male with spastic hemiparesis and lesions in the spinal cord and brainstem. Six years later he showed bilateral subclinical ON identified using OCT, visual evoked potentials (VEP) and MRI. The patient fulfilled diagnosis criteria of seronegative neuromyelitis optica (NMO). (3) A 23-year-old female with overweight and headache had bilateral optic disc swelling. With OCT and lumbar puncture, idiopathic intracranial hypertension (IIH) was excluded. Further investigation showed positive antibody for myelin oligodendrocyte glycoprotein (MOG). Conclusions: These three cases illustrate the importance of using OCT to facilitate quick, objective and accurate diagnosis of atypical or subclinical ON, and thus proper therapy.

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  • 90.
    Häkkinen, Maria
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Ekström, Curt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Distribution of intraocular pressure in a Swedish population2022Ingår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 127, nr 1, artikel-id e8829Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Increased intraocular pressure (IOP) and pseudoexfoliation (PEX) are major risk factors for open-angle glaucoma (OAG), an age-related neurodegenerative disease of significant importance for public health. There are few studies on the distribution of IOP in populations where PEX is a common finding.

    Methods: The distribution of IOP was studied in 733 subjects 65-74 years of age, examined in a population survey in the rural district of Tierp, Sweden, 1984-86. The difference between the right and left eye and the effect of which eye was measured first were examined. Odds ratios, adjusted for age and sex, according to Mantel-Haenszel (ORMH), were calculated to estimate predictors of increased IOP, defined as a pressure >= 20 mm Hg in either eye. The pressure was measured with Goldmann applanation tonometry. Automated perimetry was used to identify OAG.

    Results: The distribution of IOP was close to that of other European- derived populations. The pressure in the first measured eye was higher than in the second measured eye. Increased IOP was related to OAG and PEX, ORMH 8.97 (95% confidence interval [CI] 3.84-20.9) and 2.40 (95% CI 1.53-3.76), respectively. An IOP >= 20 mm Hg increased the risk of having been diagnosed with diabetes (ORMH 1.83; 95% CI 1.08-3.09).

    Conclusion: In this study of subjects 65-74-years- old in Sweden, the distribution of IOP was close to that of other European-derived populations. Although the difference was small, the pressure in the first measured eye was higher than in the second eye. Increased IOP was strongly related to untreated OAG and PEX.

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  • 91.
    Karimi, Annette
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper. Radiology Department, Uppsala University Hospital, Uppsala, Sweden.
    Setänen, Sirkku
    Larsson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Holmström, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Fredriksson Kaul, Ylva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Perinatal, neonatal och barnkardiologisk forskning.
    Kochukhova, Olga
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Perinatal, neonatal och barnkardiologisk forskning.
    Johansson, Martin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Perinatal, neonatal och barnkardiologisk forskning.
    Montgomery, Cecilia
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Perinatal, neonatal och barnkardiologisk forskning.
    Hellström-Westas, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Perinatal, neonatal och barnkardiologisk forskning.
    Wikström, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.
    Brain MRI findings and their association with visual impairment in young adolescents born very preterm2024Ingår i: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 66, nr 1, s. 145-154Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose

    Very preterm birth increases risk for neonatal white matter injury, but there is limited data on to what extent this persists into adolescence and how this relates to ophthalmological outcomes. The aim of this study was to assess brain MRI findings in 12-year-old children born very preterm compared to controls and their association with concurrent ophthalmological outcomes.

    Methods

    We included 47 children born very preterm and 22 full-term controls (gestational age <32 and >37 weeks, respectively). Brain MRI findings were studied in association with concurrent ophthalmological outcomes at 12-year follow-up.

    Results

    Evans index (0.27 vs 0.25, p<0.001) and a proposed “posterior ventricle index” (0.47 vs 0.45, p=0.018) were increased in children born very preterm. Higher gestational age associated with larger corpus callosum area (β=10.7, 95%CI 0.59–20.8). Focal white matter lesions were observed in 15 (32%) of very preterm children and in 1 (5%) of full-term controls. Increased posterior ventricle index increased risk for visual acuity ≤1.0 (OR=1.07×1011, 95%CI=7.78–1.48×1021) and contrast sensitivity <0.5 (OR=2.6×1027, 95%CI=1.9×108–3.5×1046). Decreased peritrigonal white matter thickness associated with impaired visual acuity (β=0.04, 95%CI 0.002–0.07).

    Conclusion

    More white matter lesions and evidence of lower white matter volume were found in children born very preterm compared with full-term controls at 12-year follow-up. The association between larger posterior ventricle index and reduced visual acuity and contrast sensitivity suggests disturbances of the posterior visual pathway due to diffuse white matter lesions.

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  • 92.
    Kaul, Ylva Fredriksson
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik.
    Rosander, Kerstin
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Hofsten, von, Claes
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Brodd, Katarina Strand
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD).
    Holmström, Gerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Oftalmiatrik.
    Kaul, Alexander
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik.
    Bohm, Birgitta
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
    Hellström-Westas, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik.
    Visual tracking in very preterm infants at 4 mo predicts neurodevelopment at 3 y of age2016Ingår i: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 80, nr 1, s. 35-42Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Typically developing infants track moving objects with eye and head movements in a smooth and predictive way at 4 mo of age, but this ability is delayed in very preterm infants. We hypothesized that visual tracking ability in very preterm infants predicts later neurodevelopment. METHOD: In 67 very preterm infants (gestational age<32wk), eye and head movements were assessed at 4 mo corrected age while the infant tracked a moving object. Gaze gain, smooth pursuit, head movements, and timing of gaze relative the object were analyzed off line. Results of the five subscales included in the Bayley Scales of Infant Development (BSID-III) at 3 y of age were evaluated in relation to the visual tracking data and to perinatal risk factors. RESULTS: Significant correlations were obtained between gaze gain and cognition, receptive and expressive language, and fine motor function, respectively, also after controlling for gestational age, severe brain damage, retinopathy of prematurity, and bronchopulmonary dysplasia. CONCLUSION: This is the first study demonstrating that the basic ability to visually track a moving object at 4 mo robustly predicts neurodevelopment at 3 y of age in children born very preterm.

  • 93.
    Kessel, Klaus
    et al.
    Univ Helsinki, HiLIFE, Inst Mol Med Finland FIMM, Helsinki, Finland.
    Mattila, Jaakko
    Univ Helsinki, Dept Ophthalmol, Cornea Serv, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland.
    Linder, Nina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH). Univ Helsinki, HiLIFE, Inst Mol Med Finland FIMM, Helsinki, Finland.
    Kivelä, Tero
    Helsinki Univ Hosp, Helsinki, Finland;Univ Helsinki, Dept Ophthalmol, Ophthalm Pathol Lab, Helsinki, Finland;Hosp Dist Helsinki, Ophthalm Pathol, Helsinki, Finland;Uusimaa Lab HUSLAB, Helsinki, Finland.
    Lundin, Johan
    Univ Helsinki, HiLIFE, Inst Mol Med Finland FIMM, Helsinki, Finland;Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
    Deep Learning Algorithms for Corneal Amyloid Deposition Quantitation in Familial Amyloidosis2020Ingår i: OCULAR ONCOLOGY AND PATHOLOGY, ISSN 2296-4681, Vol. 6, nr 1, s. 58-65Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objectives: The aim of this study was to train and validate deep learning algorithms to quantitate relative amyloid deposition (RAD; mean amyloid deposited area per stromal area) in corneal sections from patients with familial amyloidosis, Finnish (FAF), and assess its relationship with visual acuity.

    Methods: Corneal specimens were obtained from 42 patients undergoing penetrating keratoplasty, stained with Congo red, and digitally scanned. Areas of amyloid deposits and areas of stromal tissue were labeled on a pixel level for training and validation. The algorithms were used to quantify RAD in each cornea, and the association of RAD with visual acuity was assessed.

    Results: In the validation of the amyloid area classification, sensitivity was 86%, specificity 92%, and F-score 81. For corneal stromal area classification, sensitivity was 74%, specificity 82%, and F-score 73. There was insufficient evidence to demonstrate correlation (Spearman's rank correlation, -0.264, p = 0.091) between RAD and visual acuity (logMAR).

    Conclusions: Deep learning algorithms can achieve a high sensitivity and specificity in pixel-level classification of amyloid and corneal stromal area. Further modeling and development of algorithms to assess earlier stages of deposition from clinical images is necessary to better assess the correlation between amyloid deposition and visual acuity. The method might be applied to corneal dystrophies as well.

  • 94.
    Khonsari, Roman
    et al.
    CHU Pitié-Salpêtrière, Paris, France.
    Nysjö, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Bildanalys och människa-datorinteraktion. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Avdelningen för visuell information och interaktion.
    Way, Benjamin
    Great Ormond Street Hospital, London, United-Kingdom.
    Karunakaran, Tharsika
    Great Ormond Street Hospital, London, United-Kingdom.
    Nyström, Ingela
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Bildanalys och människa-datorinteraktion. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Avdelningen för visuell information och interaktion.
    Odri, Guillaume
    University of Nantes, Nantes, France.
    Dunaway, David
    Great Ormond Street Hospital, London, United-Kingdom.
    Evans, R.
    Great Ormond Street Hospital, London, United-Kingdom.
    Olszewski, Raphael
    University of Leuven, Brussels, Belgium.
    Britto, Jonathan
    Great Ormond Street Hospital, London, United-Kingdom.
    Orbital morphology in Crouzon-Pfeiffer and Apert syndromes before and after surgical correction:study by 3D cephalometry, semi-automatic segmentation and 3D shape comparison2014Ingår i: Proc. Computer Assisted Radiology and Surgery (CARS). Fukuoka, Japan, June 25-28, Springer, 2014, s. 192-193Konferensbidrag (Refereegranskat)
  • 95.
    Killer, Hanspeter E.
    et al.
    Univ Hosp Basel, Dept Biomed, Basel, Switzerland.;Univ Basel, Basel, Switzerland..
    Berberat, Jatta
    Cantonal Hosp Aarau, Dept Neuroradiol, Aarau, Switzerland..
    Wostyn, Peter
    PC Sint Amandus, Dept Psychiat, Beernem, Belgium..
    Pircher, Achmed
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Söderberg: Oftalmiatrik.
    Rossinelli, Diego
    Univ Zurich, Inst Physiol, Zurich, Switzerland..
    Posture-Dependent Collapse of the Optic Nerve Subarachnoid Space: A Combined MRI and Modeling Study2021Ingår i: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 62, nr 15, artikel-id 16Artikel i tidskrift (Övrigt vetenskapligt)
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  • 96.
    Killer, Hanspeter E.
    et al.
    Kantonsspital Aarau, Dept Ophthalmol, Aarau, Switzerland;Univ Hosp Basel, Dept Ophthalmol, Basel, Switzerland.
    Hou, Ruow
    Capital Med Univ, Beijing Tongren Hosp, Dept Neurosurg, Beijing, Peoples R China.
    Wostyn, Peter
    PC Sint Amandus, Dept Psychiat, Beernem, Belgium.
    Meyer, Peter
    Univ Hosp Basel, Dept Ophthalmol, Basel, Switzerland;Univ Hosp Basel, Dept Biomed Ocular Pharmacol & Physiol, Basel, Switzerland.
    Pircher, Achmed
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Kantonsspital Aarau, Dept Ophthalmol, Aarau, Switzerland.
    Pressure and velocity in intraocular and subarachnoid space fluid chambers: an inseparable couple2019Ingår i: Eye (London. 1987), ISSN 0950-222X, E-ISSN 1476-5454, Vol. 33, nr 3, s. 343-346Artikel i tidskrift (Övrigt vetenskapligt)
  • 97.
    Killer, Hanspeter E.
    et al.
    Univ Hosp Basel, Dept Biomed, Basel, Switzerland.;Univ Basel, Basel, Switzerland..
    Pircher, Achmed
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Söderberg: Oftalmiatrik. Univ Hosp Basel, Dept Ophthalmol, Basel, Switzerland..
    Are Generalized Reduced Cerebrospinal Fluid Dynamics and Optic Nerve Sheath Compartmentation Sequential Steps in the Pathogenesis of Normal-Tension Glaucoma?2021Ingår i: Eye and Brain, ISSN 1179-2744, Vol. 13, s. 157-158Artikel i tidskrift (Övrigt vetenskapligt)
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    FULLTEXT01
  • 98.
    Killer, Hanspeter E.
    et al.
    Kantonsspital Aarau, Dept Ophthalmol, Aarau, Switzerland;Univ Hosp Basel, Dept Ophthalmol, Basel, Switzerland.
    Pircher, Achmed
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Söderberg: Oftalmiatrik. Kantonsspital Aarau, Dept Ophthalmol, Aarau, Switzerland.
    Response to: 'Comment on: Pressure and velocity in intraocular and subarachnoid space fluid chambers: an inseparable couple'2019Ingår i: Eye (London. 1987), ISSN 0950-222X, E-ISSN 1476-5454, Vol. 33, nr 9, s. 1515-1516Artikel i tidskrift (Övrigt vetenskapligt)
  • 99.
    Killer, Hanspeter E.
    et al.
    Cantonal Hosp Aarau, Dept Ophthalmol, Aarau, Switzerland.;Univ Hosp Basel, Dept Biomed Ocular Pharmacol & Physiol, Basel, Switzerland..
    Pircher, Achmed
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Söderberg: Oftalmiatrik.
    What is the optimal glaucoma treatment: reducing aqueous humour production or facilitating its outflow?2020Ingår i: Eye (London. 1987), ISSN 0950-222X, E-ISSN 1476-5454, Vol. 34, nr 10, s. 1719-1721Artikel i tidskrift (Övrigt vetenskapligt)
  • 100. Killer, Hanspeter E.
    et al.
    Pircher, Achmed
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Oftalmiatrik.
    Fleischman, David
    Intraocular Pressure and Cerebrospinal Fluid: An Intricate Relationship2024Ingår i: Journal of neuro-ophthalmology, ISSN 1070-8022, E-ISSN 1536-5166, Vol. 44, nr 1, s. e205-e205Artikel i tidskrift (Övrigt vetenskapligt)
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