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  • 6251.
    Aldskogius, Hans
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Recension av Phillips, R.: Mapping men and empire. A geography ofadventure1998In: Geografiska Annaler, p. 126-127Article, book review (Other scientific)
  • 6252.
    Aldskogius, Hans
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences.
    Regional identitet och förändring i den regionala samverkans samhälle: föredrag och diskussioner vid Kulturgeografiska institutionens vid Uppsala universitet symposium 1-3 december 19771978Conference proceedings (editor) (Other academic)
  • 6253.
    Aldskogius, Hans
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Turism i Baskien1999In: Geografiska Notiser, no 1999:4, p. 246-251Article in journal (Other scientific)
  • 6254.
    Aldskogius, Hans
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences.
    Vacation House Settlement in the Siljan Region1967In: Geografiska Annaler. Series B, Human Geography, ISSN 0435-3684, E-ISSN 1468-0467, Vol. 49, no 2, p. 69-95Article in journal (Refereed)
  • 6255.
    Aldskogius, Hans
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Where sports and money meet. The economic geography of an ice hockeystadium1995In: The stadium and the city, Keele University Press , 1995, p. 255-275Chapter in book (Other scientific)
  • 6256.
    Aldskogius, Hans
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Aldskogius, Maj
    Uppsalas första kvinnliga professor1995In: Universitetets bildvärld - strövtåg genom historien, konsten och samlingarna, Uppsala: Uppsala universitet , 1995, p. 182-183Chapter in book (Other scientific)
  • 6257.
    Aldskogius, Hans
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Johansson, Bernth
    Kulturgeografin i kvarteret Lagerträdet : en dokumentation av en byggnad och institutionsmiljö i Uppsala åren 1958-19971998Book (Other scientific)
  • 6258.
    Aldskogius, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Regenerative neurobiology.
    Animal models of spinal cord repair2012Collection (editor) (Other academic)
  • 6259.
    Aldskogius, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Mechanisms and consequences of microglial responses to peripheral axotomy2011In: Frontiers in Bioscience, ISSN 1093-9946, E-ISSN 1093-4715, Vol. 3, p. 857-868Article in journal (Refereed)
    Abstract [en]

    Microglia respond rapidly to injury of peripheral nerve axons (axotomy). This response is integrated into the responses of the injured neurons, i.e. processes for neuron survival, axon regeneration and restoration of target contact. The microglial response is also integrated in changes in presynaptic terminals on axotomized motor or autonomic neurons and in changes in the central terminals of peripherally axotomized sensory neurons. Microglia also has an established role in interacting with astrocytes to shape their response to peripheral axotomy. Axotomy models in mice have demonstrated a role for microglia in regulating the entry of lymphocytes into motor nuclei or sensory areas following peripheral axotomy. Whether this is a universal component of peripheral nerve injury remains to be determined. Under certain circumstances, microglia activated by axotomy are major contributors to CNS pathology, e.g. in models of neuropathic pain. However, the general roles played by microglia after peripheral nerve injury are still incompletely understood. Early proposals that the microglial reaction to peripheral nerve injury is preparatory for the eventuality of neuron degeneration may still have relevance.

  • 6260.
    Aldskogius, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Microglia in neuroregeneration2001In: Microscopy research and technique (Print), ISSN 1059-910X, E-ISSN 1097-0029, Vol. 54, no 1, p. 40-46Article in journal (Refereed)
    Abstract [en]

    Microglia has the potential to produce and release a range of factors that directly and/or indirectly promote regeneration in the injured nervous system. The overwhelming evidence indicates, however, that this potential is generally not expressed in vivo. Activated microglia may enhance neuronal degeneration following axotomy, thereby counteracting functional recovery. Microglia does not seem to contribute significantly to axonal outgrowth after peripheral nerve injury, since this process proceeds uneventful even if perineuronal microglia is eliminated. The phagocytic phenotype of microglia is highly suppressed during Wallerian degeneration in the central nervous system. Therefore, microglia is incapable of rapid and efficient removal of myelin debris and its putative growth inhibitory components. In this way, microglia may contribute to regeneration failure in the central nervous system. Structural and temporal correlations are compatible with participation by perineuronal microglia in axotomy-induced shedding of presynaptic terminals, but direct evidence for such participation is lacking. Currently, the most promising case for a promoting effect on neural repair by activated microglia appears to be as a mediator of collateral sprouting, at least in certain brain areas. However, final proof for a critical role of microglia in these instances is still lacking. Results from in vitro studies demonstrate that microglia can develop a regeneration supportive phenotype. Altering the microglial involvement following neural injury from a typically passive or even counterproductive state and into a condition where these cells are actively supporting regeneration and plasticity is, therefore, an exciting challenge and probably a realistic goal.

  • 6261.
    Aldskogius, Håkan
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Mikroglia - nya målceller för neurologisk terapi2000In: Läkartidningen, Vol. 97, p. 3358-Article in journal (Other scientific)
  • 6262.
    Aldskogius, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Regulation of microglia: potential new drug targets in the CNS.2001In: Expert opinion on therapeutic targets, ISSN 1472-8222, E-ISSN 1744-7631, Vol. 5, no 6, p. 655-668Article in journal (Refereed)
    Abstract [en]

    Microglia respond to any disturbance in the CNS which poses a threat to physiological homeostasis. Although these responses are secondary, mainly to neuronal alterations, the way the microglial response evolves in many situations promotes further damage to the CNS. The list of clinical conditions in which this situation is a major problem is continuously growing and includes neurodegenerative diseases, stroke, trauma, demyelinating disorders and neuropathic pain. The significance of microglia for the pathogenesis of neurological and neuropsychiatric conditions has led to a rapidly expanding search for therapeutic possibilities to regulate microglial activity. As will be clear from this review, treatments which are currently available appear to offer some positive effects but are still far from satisfactory. A major challenge is to understand the mechanisms that determine whether activated microglia will develop into a cytotoxic or a cytoprotective component.

  • 6263.
    Aldskogius, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. neuroanatomi.
    Repairing CNS myelin: astrocytes have to do their jobs2005In: Experimental Neurology, ISSN 0014-4886, E-ISSN 1090-2430, Vol. 192, no 1, p. 7-10Article in journal (Refereed)
  • 6264.
    Aldskogius, Håkan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Berens, Christian
    Kanaykina, Nadegda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Liakhovitskaia, Anna
    Medvinsky, Alexander
    Sandelin, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Schreiner, Silke
    Wegner, Michael
    Hjerling-Leffler, Jens
    Kozlova, Elena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Regulation of boundary cap neural crest stem cell differentiation after transplantation2009In: Stem Cells, ISSN 1066-5099, E-ISSN 1549-4918, Vol. 27, no 7, p. 1592-1603Article in journal (Refereed)
    Abstract [en]

    Success of cell replacement therapies for neurological disorders will dependlargely on the optimization of strategies to enhance viability and control thedevelopmental fate of stem cells after transplantation. Once transplanted,stem/progenitor cells display a tendency to maintain an undifferentiatedphenotype or differentiate into inappropriate cell types. Gain and loss offunction experiments have revealed key transcription factors which drivedifferentiation of immature stem/progenitor cells toward more mature stages andeventually to full differentiation. An attractive course of action to promotesurvival and direct the differentiation of transplanted stem cells to a specific cell type would therefore be to force expression of regulatory differentiationmolecules in already transplanted stem cells, using inducible gene expressionsystems which can be controlled from the outside. Here, we explore thishypothesis by employing a tetracycline gene regulating system (Tet-On) to drivethe differentiation of boundary cap neural crest stem cells (bNCSCs) toward asensory neuron fate after transplantation. We induced the expression of the keytranscription factor Runx1 in Sox10-expressing bNCSCs. Forced expression of Runx1strongly increased transplant survival in the enriched neurotrophic environmentof the dorsal root ganglion cavity, and was sufficient to guide differentiationof bNCSCs toward a nonpeptidergic nociceptive sensory neuron phenotype both invitro and in vivo after transplantation. These findings suggest that exogenousactivation of transcription factors expression after transplantation instem/progenitor cell grafts can be a constructive approach to control theirsurvival as well as their differentiation to the desired type of cell and thatthe Tet-system is a useful tool to achieve this.

  • 6265. Aldskogius, Håkan
    et al.
    Kozlova, Elena
    Dorsal root injury for the study of spinal cord injury repair2012In: Animal models of spinal cord repair, New York Heidelberg Dordrecht London: Humana Press, 2012, p. 109-129Chapter in book (Other academic)
    Abstract [en]

    Dorsal root injury provides opportunities for highly reproducible lesions and for detailed anatomical, physiological and behavioral outcome assessment with high precision and validity. Dorsal root injury models are used to several aspects of relevance to spinal cord injury repair: i) mechanisms of regeneration failure in the central nervous system and how to overcome it, ii) axon degeneration, as well as myelin degradation and elimination in the central nervous system - their roles and possible manipulations in spinal cord repair, iii) consequences in the spinal cord of mimicking human plexus injuries by dorsal root avulsion, including its effect on neuron survival, inflammatory processes and vascular dysfunction, and iv) therapeutic strategies which may be translated to the treatment of clinical plexus avulsion injuries. This chapter describes various dorsal root injury models, their relationship to basic and translational aspects of spinal cord injury repair, as well as basic experimental procedures associated with these models in rat and mouse.

  • 6266.
    Aldskogius, Håkan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Kozlova, Elena N.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Central neuron-glial and glial-glial interactions following axon injury1998In: Progress in Neurobiology, ISSN 0301-0082, E-ISSN 1873-5118, Vol. 55, no 1, p. 1-26Article in journal (Refereed)
    Abstract [en]

    Axon injury rapidly activates microglial and astroglial cells close to the axotomized neurons. Following motor axon injury, astrocytes upregulate within hour(s) the gap junction protein connexin-43, and within one day glial fibrillary acidic protein (GFAP). Concomitantly, microglial cells proliferate and migrate towards the axotomized neuron perikarya. Analogous responses occur in central termination territories of peripherally injured sensory ganglion cells. The activated microglia express a number of inflammatory and immune mediators. When neuron degeneration occurs, microglia act as phagocytes. This is uncommon after peripheral nerve injury in the adult mammal, however, and the functional implications of the glial cell responses in this situation are unclear. When central axons are injured, the glial cell responses around the affected neuron perikarya appears to be minimal or absent, unless neuron degeneration occurs. Microglia proliferate, and astrocytes upregulate GFAP along central axons undergoing anterograde, Wallerian, degeneration. Although microglia develop into phagocytes, they eliminate the disintegrating myelin very slowly, presumably because they fail to release molecules which facilitate phagocytosis. During later stages of Wallerian degeneration, oligodendrocytes express clusterin, a glycoprotein implicated in several conditions of cell degeneration. A hypothetical scheme for glial cell activation following axon injury is discussed, implying the injured neurons initially interact with adjacent astrocytes. Subsequently, neighbouring resting microglia are activated. These glial reactions are amplified by paracrine and autocrine mechanisms, in which cytokines appear to be important mediators. The specific functional properties of the activated glial cells will determine their influence on neuronal survival, axon regeneration, and synaptic plasticity. The control of the induction and progression of these responses are therefore likely to be critical for the outcome of, for example, neurotrauma, brain ischemia and chronic neurodegenerative diseases.

  • 6267.
    Aldskogius, Håkan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Kozlova, Elena N.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Microglia and Neuropathic Pain2013In: CNS & Neurological Disorders: Drug Targets, ISSN 1871-5273, E-ISSN 1996-3181, Vol. 12, no 6, p. 768-772Article in journal (Refereed)
    Abstract [en]

    Neuropathic pain is a serious consequence of injury or disease in the nervous system itself. Current treatment options for this condition are often unsatisfactory. From being originally viewed as a diseased caused by neuronal dysfunction, a growing body of evidence implicate activated microglia as a key player in the development of this pain condition. In this review, some of the evidence for this proposal is briefly discussed and placed in a translational context, pointing out the difficulties in translating commonly used animal models of neuropathic pain to the clinical condition, as well as emphasizing the broader role of activated microglia in the injured or diseased nervous system.

  • 6268.
    Aldskogius, Håkan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Kozlova, Elena N.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Strategies for repair of the deafferented spinal cord2002In: Brain Research Reviews, ISSN 0165-0173, E-ISSN 1872-6321, Vol. 40, no 1-3, p. 301-308Article in journal (Refereed)
    Abstract [en]

    Deafferentation of the spinal cord by interruption of the sensory fibers in the dorsal roots highlights the problem of regeneration failure in the central nervous system. The injured dorsal root axons regenerate steadily, albeit slowly, in the peripheral compartment of the dorsal root, but abruptly cease to elongate when confronted with the interface between the peripheral and central nervous system, the dorsal root transitional zone (DRTZ). The glial cells of the CNS and their products together form this regeneration barrier. Recent years have witnessed several successful approaches to, at least in part, overcome this barrier. Particularly promising results have been obtained by (1). the replacement of adult non-regenerating dorsal root ganglion neurons with corresponding cells from embryonic or fetal donors, (2). the implantation of olfactory ensheathing cells at the DRTZ, and (3). immediate intrathecal infusion of growth factors to which dorsal root ganglion cells respond. In all these instances, growth of sensory axons into the adult spinal cord, as well as return of spinal cord connectivity, have been demonstrated. These findings suggest routes towards treatment strategies for plexus avulsion, and contribute to our understanding of possibilities to overcome regeneration failure in the spinal cord.

  • 6269.
    Aldskogius, Håkan
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Liu, Li
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Eriksson, Petri
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Persson, Jonas
    Svensson, Mikael
    The response of microglia to axon injury1997In: Neurochemistry, 1997, p. 549-Chapter in book (Other scientific)
  • 6270.
    Aldskogius, Håkan
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Liu, Li
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Svensson, Mikael
    Clusterin in models of central and peripheral injury and for ischemia and trauma1999In: In: Clusterin in normal brain functions and during neurodegeneration, R.G.Landes Company , 1999, p. 99-Chapter in book (Other scientific)
  • 6271.
    Aldskogius, Håkan
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Liu, Li
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Svensson, Mikael
    Glial responses to synaptic damage and plasticity1999In: J Neurosci Res, Vol. 58, p. 33-Article in journal (Refereed)
  • 6272.
    Aldskogius, Maj
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Anjans fjällstation - en pärla i Jämtlands fjällvärld2003Book (Other scientific)
  • 6273. Aldskogius, Maj
    "… kunn’ I dock så wackert låta …": Uppsala Akademiska Kammarkör 50 år2007Collection (editor) (Other academic)
    Abstract [en]

    A 50th anniversary portrait of the artistically ambitious Academy Chamber Choir of Uppsala is drawn by a variety of authors: choristers, listeners and musicologists,all familiar with choral singing and choral music.

    The characteristics of the choir repertoire are extensively described by conductors, composers, Swedish and foreign soloists and instrumentalists. The choir has commissioned and delivered first performances of works by a number of Swedish composers.

    It can also be noticed how economic and organizational changes in society influence the motility of choristers, the number of performances in concert halls, churches as well as other circumstances and possibly also the very choral sound.

    The choir is invited to choral festivals, goes on tours in Europe and North America and hosts visiting choirs. The choir can also be heard on records.

  • 6274.
    Aldskogius, Maj
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences.
    Population Change and Urban Growth: A Study of Large and Medium-Sized Urban Regions in Sweden1970In: Geografiska Annaler. Series B, Human Geography, ISSN 0435-3684, E-ISSN 1468-0467, Vol. B 52, no 2, p. 131-140Article in journal (Refereed)
  • 6275.
    Aldujaili, Aya
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Berndtson, Emma
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Hedström, Tom
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Piccolo, Sofia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Rahmani, Zakaria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Åhlén, Michelle
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Hur partikelstorleksfördelning påverkar kritiska parametrar för medicinska enheter2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Projektet har inriktning på Galdermas produkter Deflux och Solesta, de ämnen som produkterna är uppbyggda av (dextran och hyaluronsyra) har studerats laborativt. Ändringar av parametrar såsom koncentration av dextran men även i siktningsmetod (dubbel- respektive enkelsiktningar samt olika filterstorlekar) har genomförts. Resultatet av dessa ändringar har erhållits med hjälp av mikroskop, laserdiffraktometer samt dragprovare. De slutsatser som har kunnat dras från resultaten är att med ökad partikeldiameter erhålls en lägre extruderingskraft, oavsett om använd siktningsmetod var enkel- eller dubbelsiktning. Vidare så erhålls en större extruderingskraft med ökad koncentration av dextran.

  • 6276.
    Aldujaili, Aya
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Berndtson, Emma
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Hedström, Tom
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Piccolo, Sofia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Rahmani, Zakaria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Åhlén, Michelle
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Hur partikelstorleksfördelning påverkar kritiska parametrar för medicinska enheter2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Projektet har inriktning på Galdermas produkter Deflux och Solesta, de ämnen som produkterna är uppbyggda av (dextran och hyaluronsyra) har studerats laborativt. Ändringar av parametrar såsom koncentration av dextran men även i siktningsmetod (dubbel- respektive enkelsiktningar samt olika filterstorlekar) har genomförts. Resultatet av dessa ändringar har erhållits med hjälp av mikroskop, laserdiffraktometer samt dragprovare. De slutsatser som har kunnat dras från resultaten är att med ökad partikeldiameter erhålls en lägre extruderingskraft, oavsett om använd siktningsmetod var enkel- eller dubbelsiktning. Vidare så erhålls en större extruderingskraft med ökad koncentration av dextran.

  • 6277. Aldulaymi, Bahir
    et al.
    Byström, Per
    Berglund, Åke
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    Christensen, Ib J.
    Brunner, Nils
    Nielsen, Hans J.
    Glimelius, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    High Plasma TIMP-1 and Serum CEA Levels during Combination Chemotherapy for Metastatic Colorectal Cancer Are Significantly Associated with Poor Outcome2010In: Oncology, ISSN 0030-2414, E-ISSN 1423-0232, Vol. 79, no 1-2, p. 144-149Article in journal (Refereed)
    Abstract [en]

    Objective: To evaluate whether combination chemotherapy leads to early changes in plasma TIMP-1 and serum carcinoembryonic antigen (CEA) levels in patients with metastatic colorectal cancer (mCRC), and whether such changes relate to subsequent objective response, time to progression (TTP) and overall survival. Materials and Methods: Eighty-eight patients with mCRC were included. Blood samples were collected before initiation and after 2, 4 and 6 weeks of treatment with an irinotecan-5-fluorouracil combination. Plasma TIMP-1 and serum CEA levels were determined by validated ELISA platforms. The first response evaluation was performed after 8 weeks of chemotherapy. Results: Median plasma TIMP-1 and serum CEA levels did not change significantly during 6 weeks of treatment. High plasma TIMP-1 and high serum CEA levels before treatment and at weeks 2, 4 and 6 were related to poor objective response. Moreover, high levels of plasma TIMP-1 before treatment and at weeks 2 and 4 were significantly associated with short TTP, while high levels of serum CEA at week 4 were significantly associated with short TTP. Finally, high levels of plasma TIMP- 1 before and during treatment were significantly associated with poor overall survival; p < 0.0001 in all 4 determinations. A similar association between serum CEA and overall survival could only be demonstrated before treatment. Conclusion: Median plasma TIMP-1 or serum CEA levels do not change significantly during the first 6 weeks of chemotherapy for mCRC. The results indicate that plasma TIMP-1 in particular and serum CEA may be valuable biomarkers even in samples collected during treatment with chemotherapy.

  • 6278.
    Aldén, Björn
    et al.
    Göteborgs botaniska trädgård.
    Ryman, Svengunnar
    Uppsala University, Museums etc., Museum of Evolution.
    Hjertson, Mats
    Uppsala University, Museums etc., Museum of Evolution.
    Våra kulturväxters namn: ursprung och användning2009Book (Other academic)
  • 6279. Aldén, Jenny
    Svenska infertila pars attityder till embryodonation2011Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • 6280.
    Aldén, Liselotte
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Ansén Nilsson, Marianne
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Barney, Andrew
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Ekman, Marita Engberg
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Nedmontering av vindkraftverk och efterbehandling av platsen2014Report (Other (popular science, discussion, etc.))
    Abstract [en]

    This report has analyzed and compared the wind power decommissioning laws, regulations, permits, history, activity costs and the disposal and restoration options inSweden and around the world. The onshore and offshore wind power decommissioning laws and regulations in several countries are examined. Specific attention was paid to the restoration and decommissioning financial security requirements of these countries. None of the countries reviewed had exactly the same requirements but there were similarities in determining who decided the requirements and if a security was stipulated.The history of wind power decommissioning in Sweden and Denmark is recounted and a case study of decommissioning cases in Sweden, Denmark and the United States of America was conducted. The case study addresses the costs of the various steps in decommissioning and the possible levels of restoration. The case study’s results indicate that a turbine’s installed capacity, location and the level of restoration have the greatest influence on the total cost of decommissioning.The handling of the wind turbine once it has been decommissioned is addressed and the disposal options for the turbines components are reviewed. Three options exist today for wind turbines after they have been decommissioned: refurbishing, reselling or recycling. Refurbishing components of a wind turbine can potentially extend its life but is subject to potential cost, reliability and availability constraints. Reselling the wind turbine for further use is a valid option but it does require there be a demand for the turbine. Recycling values depend heavily on the size and type of scrap and on the current metal prices. Additionally some components cannot be recycled in an economically feasible way today, primarily the blades. The requirements for restoration and for decommissioning financial security in wind power project environmental permits and notification permits in Sweden from 2010 to 2012 are also reviewed. Nearly all environmental permits reviewed required a decommissioning security. The amount of security required ranged widely, but a single security amount of 300000 SEK was used in a large number of the permits. The required restoration levels in the environmental permits were mostly undefined and nearly all permits passed the authority for determining the final restoration level to the local regulator. The majority of the notification permits reviewed contained restoration requirements similar to that found in the environmental permits but by law could not contain a financial security.A comparison of the number of wind turbines with environmental permits and notification permits following the2009regulation change is performed. However, as there wasno reliable data no trend or forecast could be made.The report concludes by noting the wide range of regulations and requirements found in the studied countries. The conclusion also notes the specificfindings from the case study and from the review of the environmental and notification permits. The findings are compared and two areas have been identified for future in-depth discussion, namely the amount of financial security and when and who should determine the degree of restoration.

  • 6281.
    Aldén, Liselotte
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Nätverket för vindbruk.
    Ottvall, Richard
    Da Silva Soares, José Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Nätverket för vindbruk.
    Klein, Jason
    Nätverket för vindbruk.
    Liljenfeldt, Johanna
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Nätverket för vindbruk.
    Samexistens örnar och vindkraft på Gotland2017Report (Other (popular science, discussion, etc.))
  • 6282.
    Aldén, Liselotte
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Nätverket för vindbruk.
    Ottvall, Richard
    Da Silva Soares, José Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Nätverket för vindbruk.
    Klein, Jason
    Nätverket för vindbruk.
    Liljenfeldt, Johanna
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Nätverket för vindbruk.
    Samexistens örnar och vindkraft på Gotland2017Report (Other (popular science, discussion, etc.))
  • 6283.
    Aldén, Liselotte
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. The National Network for Wind Utilization.
    Ridbäck, Ulrika
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. The National Network for Wind Utilization.
    New and Ongoing Wind Power Research in Sweden 2018: A compilation of Swedish research programs and new scientific publications on wind energy2019Report (Other (popular science, discussion, etc.))
    Abstract [en]

    The Node for education and competence in the National network for wind utilization annually publishes a summary of new and ongoing wind power research in Sweden. The aim of this summary is to provide an easily accessible overview of what is happening annually in wind power research for interested parties. This compilation is divided into two sections. The first is a presentation of the research centres and research programmes active in wind power research in Sweden. Then a topic-based list of the wind power research published in 2018 follows where at least one of the authors is active at a Swedish university. Here one also can find doctoral and licentiate theses as well as theses at bachelor and master levels that have been published during the year.

  • 6284.
    Aldén, Liselotte
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Nätverket för vindbruk.
    Ridbäck, Ulrika
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Nätverket för vindbruk.
    Ny och pågående vindkraftsforskning i Sverige 2018: En sammanställning av svenska forskningsprogram och publikationer inom vindkraftsområdet2019Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Uppsala universitet Campus Gotland producerar årligen en sammanställning av svensk forskning om vindkraft i serien Ny och pågående forskning om vindkraft i Sverige. Syftet med dessa publikationer är att intresserade ska få en lättillgänglig överblick av vad som skett under året inom vindkraftsforskningen i landet. Sammanställningen är indelad i två avsnitt. Det första är en presentation av de forskningsprogram och forskningscentra som är verksamma inom vindkraftsforskning i Sverige med fokus på deras pågående projekt. Därefter följer en ämnesindelad förteckning över publicerad forskning om vindkraft under aktuellt år vid svenska universitet, högskolor och institutioner. Där ingår vetenskapliga artiklar och rapporter, doktors- och licentiatavhandlingar samt uppsatser på kandidat-, magister- och mastersnivå samt sammanfattningar med statistik och jämförelser med tidigare år.

  • 6285.
    Aldén, Maggie
    Uppsala University, Disciplinary Domain of Science and Technology.
    Crystal chemistry of the solid electrolyte magnesium stabilized ß"-alumina1985Doctoral thesis, comprehensive summary (Other academic)
  • 6286.
    Aldén, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology.
    Surface energetics from one-electron Green's function theory 1994Doctoral thesis, comprehensive summary (Other academic)
  • 6287.
    Aldén, Maria
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    Nominalfraser i tal och skrift2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I den här uppsatsen redovisas en jämförelse av den muntliga och skriftliga förmågan hos tolv vuxna inlärare i svenska, genom en performansanalys av texter och transkriberade samtal från testet Tisus (Test i svenska för universitets-och högskolestudier). Språkdraget som jämförs är nominalfrasen och syftet med studien är att undersöka huruvida det finns en skillnad i utbyggnad och korrekthet mellan muntlig och skriftlig produktion, samt om det finns en skillnad i testtagarnas processbarhetsnivå enligt processbarhetsteorin. Resultatet visar att andelen enkla nominalfraser är större i tal än i skrift. Även korrektheten är större i den muntliga produktionen än i den skriftliga, vilket går emot tidigare forskning. När det gäller processbarhetsnivå visar resultatet att det inte finns några skillnader testtagarnas muntliga och skriftliga processbarhetsnivå

  • 6288.
    Aldén, Sofie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    God styrelsesed i svenska aktiemarknadsbolag: – En analys av styrelsens roll i aktiemarknadsbolaget och vilka rättsliga normer styrelsen har att handla efter2013Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • 6289. Alecian, E.
    et al.
    Kochukhov, Oleg
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy.
    Neiner, C.
    Wade, G. A.
    de Batz, B.
    Henrichs, H.
    Grunhut, J. H.
    Bouret, J. -C
    Briquet, M.
    Gagne, M.
    Naze, Y.
    Oksala, M. E.
    Rivinius, T.
    Townsend, R. H. D.
    Walborn, N. R.
    Weiss, W.
    First HARPSpol discoveries of magnetic fields in massive stars2011In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 536, p. L6-Article in journal (Refereed)
    Abstract [en]

    In the framework of the Magnetism in Massive Stars (MiMeS) project, a HARPSpol Large Program at the 3.6m-ESO telescope has recently started to collect high-resolution spectropolarimetric data of a large number of Southern massive OB stars in the field of the Galaxy and in many young clusters and associations. We report on the first discoveries of magnetic fields in two massive stars with HARPSpol - HD 130807 and HD 122451, and confirm the presence of a magnetic field at the surface of HD 105382 that was previously observed with a low spectral resolution device. The longitudinal magnetic field measurements strongly vary for HD 130807 from similar to-100 G to similar to 700 G. Those of HD 122451 and HD 105382 are less variable with values ranging from similar to-40 to -80 G, and from similar to-300 to -600 G, respectively. The discovery and confirmation of three new magnetic massive stars, including at least two He-weak stars, is an important contribution to one of MiMeS objectives: the understanding of the origin of magnetic fields in massive stars and their impact on stellar structure and evolution.

  • 6290. Alecian, E.
    et al.
    Kochukhov, Oleg
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy.
    Petit, V.
    Grunhut, J.
    Landstreet, J.
    Oksala, M. E.
    Wade, G. A.
    Hussain, G.
    Neiner, C.
    Bohlender, D.
    Discovery of new magnetic early-B stars within the MiMeS HARPSpol survey2014In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 567, p. A28-Article in journal (Refereed)
    Abstract [en]

    Context. The Magnetism in Massive Stars (MiMeS) project aims at understanding the origin of the magnetic fields in massive stars as well as their impact on stellar internal structure, evolution, and circumstellar environment. Aims. One of the objectives of the MiMeS project is to provide stringent observational constraints on the magnetic fields of massive stars; however, identification of magnetic massive stars is challenging, as only a few percent of high-mass stars host strong fields detectable with the current instrumentation. Hence, one of the first objectives of the MiMeS project was to search for magnetic objects among a large sample of massive stars, and to build a sub-sample for in-depth follow-up studies required to test the models and theories of fossil field origins, magnetic wind confinement and magnetospheric properties, and magnetic star evolution. Methods. We obtained high-resolution spectropolarimetric observations of a large number of OB stars thanks to three large programs (LP) of observations that have been allocated on the high-resolution spectropolarimeters ESPaDOnS, Narval, and the polarimetric module HARPSpol of the HARPS spectrograph. We report here on the methods and first analysis of the HARPSpol magnetic detections. We identified the magnetic stars using a multi-line analysis technique. Then, when possible, we monitored the new discoveries to derive their rotation periods, which are critical for follow-up and magnetic mapping studies. We also performed a first-look analysis of their spectra and identified obvious spectral anomalies (e. g., surface abundance peculiarities, Ha emission), which are also of interest for future studies. Results. In this paper, we focus on eight of the 11 stars in which we discovered or confirmed a magnetic field from the HARPSpol LP sample (the remaining three were published in a previous paper). Seven of the fields were detected in early-type Bp stars, while the last field was detected in the Ap companion of a normal early B-type star. We report obvious spectral and multiplicity properties, as well as our measurements of their longitudinal field strengths, and their rotation periods when we are able to derive them. We also discuss the presence or absence of Ha emission with respect to the theory of centrifugally-supported magnetospheres.

  • 6291. Alecian, E.
    et al.
    Neiner, C.
    Mathis, S.
    Catala, C.
    Kochukhov, Oleg
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Landstreet, J.
    The dramatic change of the fossil magnetic field of HD 190073: Evidence of the birth of the convective core in a Herbig star?2013In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 549, p. L8-Article in journal (Refereed)
    Abstract [en]

    In the context of the ESPaDOnS and Narval spectropolarimetric surveys of Herbig Ae/Be stars, we discovered and then monitored the magnetic field of HD 190073 over more than four years, from 2004 to 2009. Our observations all displayed similar Zeeman signatures in the Stokes V spectra, indicating that HD 190073 hosted an aligned dipole, stable over many years, consistent with a fossil origin. We obtained new observations of the star in 2011 and 2012 and detected clear variations of the Zeeman signature on timescales of days to weeks, indicating that the configuration of its field has changed between 2009 and 2011. Such a sudden change of external structure of a fossil field has never previously been observed in any intermediate or high-mass star. HD 190073 is an almost entirely radiative pre-main sequence star, probably hosting a growing convective core. We propose that this dramatic change is the result of the interaction between the fossil field and the ignition of a dynamo field generated in the newly-born convective core.

  • 6292. Alehagen, Urban
    et al.
    Aaseth, Jan
    Alexander, Jan
    Svensson, Erland
    Johansson, Peter
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10-A mechanism behind reduced cardiovascular mortality?2018In: Biofactors, ISSN 0951-6433, E-ISSN 1872-8081, Vol. 44, no 2, p. 137-147Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: In an intervention study where 221 healthy elderly persons received selenium and coenzyme Q10 as a dietary supplement, and 222 received placebo for 4 years we observed improved cardiac function and reduced cardiovascular mortality. As fibrosis is central in the aging process, we investigated the effect of the intervention on biomarkers of fibrogenic activity in a subanalysis of this intervention study.

    MATERIAL AND METHODS: In the present subanalysis 122 actively treated individuals and 101 controls, the effect of the treatment on eight biomarkers of fibrogenic activity were assessed. These biomarkers were: Cathepsin S, Endostatin, Galectin 3, Growth Differentiation Factor-15 (GDF-15), Matrix Metalloproteinases 1 and 9, Tissue Inhibitor of Metalloproteinases 1 (TIMP 1) and Suppression of Tumorigenicity 2 (ST-2). Blood concentrations of these biomarkers after 6 and 42 months were analyzed by the use of T-tests, repeated measures of variance, and factor analyses.

    RESULTS: Compared with placebo, in those receiving supplementation with selenium and coenzyme Q10, all biomarkers except ST2 showed significant decreased concentrations in blood. The changes in concentrations, that is, effects sizes as given by partial eta2 caused by the intervention were considered small to medium.

    CONCLUSION: The significantly decreased biomarker concentrations in those on active treatment with selenium and coenzyme Q10 compared with those on placebo after 36 months of intervention presumably reflect less fibrogenic activity as a result of the intervention. These observations might indicate that reduced fibrosis precedes the reported improvement in cardiac function, thereby explaining some of the positive clinical effects caused by the intervention. © 2017 BioFactors, 2017.

  • 6293.
    Alehagen, Urban
    et al.
    Linkoping Univ, Dept Med & Hlth Sci, Div Cardiovasc Med, SE-58185 Linkoping, Sweden.
    Alexander, Jan
    Norwegian Inst Publ Hlth, N-0403 Oslo, Norway.
    Aaseth, Jan
    Innlandet Hosp Trust, Res Dept, Brumunddal, Norway;Inland Norway Univ Appl Sci, N-2411 Elverum, Norway.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK2019In: Journal of Inflammation, ISSN 1476-9255, E-ISSN 1476-9255, Vol. 16, article id 5Article in journal (Refereed)
    Abstract [en]

    Background:

    Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons with a low intake of selenium. There are indications that one of the mechanisms of this positive effect is a decrease in inflammation.

    Methods:

    Osteopontin, osteoprotegerin, sTNF receptor 1, sTNF receptor 2 and the tumor necrosis factor-like weak inducer of apoptosis called TWEAK, were determined in plasma after 6 months and 42months in 219 community-living elderly persons, of whom 119 received supplements of selenium (200g/day) and coenzyme Q10 (200mg/day), and 101 received a placebo. Repeated measures of variance were used to evaluate the levels, and the results were validated through ANCOVA analyses with adjustments for important covariates.

    Results:

    Significantly lower concentrations of four of the five biomarkers for inflammation were observed as a result of the intervention with the supplements. Only TWEAK did not show significant differences.

    Conclusion:

    In this sub-analysis of the intervention with selenium and coenzyme Q10 or placebo in an elderly community-living population, biomarkers for inflammation were evaluated. A significantly lower concentration in four of the five biomarkers tested could be demonstrated as a result of the supplementation, indicating a robust effect on the inflammatory system. The decrease in inflammation could be one of the mechanisms behind the positive clinical results on reduced cardiovascular morbidity and mortality reported earlier as a result of the intervention. The study is small and should be regarded as hypothesis-generating, but nonetheless adds important data about mechanisms presently known to increase the risk of clinical effects such as reduced cardiovascular mortality, increased cardiac function and better health-related quality of life scoring, as previously demonstrated in the active treatment group.

  • 6294.
    Alehagen, Urban
    et al.
    Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, SE-581 85 Linköping, Sweden..
    Alexander, Jan
    Norwegian Institute of Public Health, N-0403 Oslo, Norway..
    Aaseth, Jan
    Inland Norway University of Applied Sciences, N-2411 Elverum, Norway..
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK.2019In: Journal of Inflammation, ISSN 1476-9255, E-ISSN 1476-9255, Vol. 16, article id 5Article in journal (Refereed)
    Abstract [en]

    Background: Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons with a low intake of selenium. There are indications that one of the mechanisms of this positive effect is a decrease in inflammation.

    Methods: Osteopontin, osteoprotegerin, sTNF receptor 1, sTNF receptor 2 and the tumor necrosis factor-like weak inducer of apoptosis called TWEAK, were determined in plasma after 6 months and 42 months in 219 community-living elderly persons, of whom 119 received supplements of selenium (200 μg/day) and coenzyme Q10 (200 mg/day), and 101 received a placebo. Repeated measures of variance were used to evaluate the levels, and the results were validated through ANCOVA analyses with adjustments for important covariates.

    Results: Significantly lower concentrations of four of the five biomarkers for inflammation were observed as a result of the intervention with the supplements. Only TWEAK did not show significant differences.

    Conclusion: In this sub-analysis of the intervention with selenium and coenzyme Q10 or placebo in an elderly community-living population, biomarkers for inflammation were evaluated. A significantly lower concentration in four of the five biomarkers tested could be demonstrated as a result of the supplementation, indicating a robust effect on the inflammatory system. The decrease in inflammation could be one of the mechanisms behind the positive clinical results on reduced cardiovascular morbidity and mortality reported earlier as a result of the intervention. The study is small and should be regarded as hypothesis-generating, but nonetheless adds important data about mechanisms presently known to increase the risk of clinical effects such as reduced cardiovascular mortality, increased cardiac function and better health-related quality of life scoring, as previously demonstrated in the active treatment group .

    Trial registration: The intervention study was registered at Clinicaltrials.gov, and has the identifier NCT01443780 and registered on 09/30/2011.

  • 6295.
    Alehagen, Urban
    et al.
    Linkoping Univ, Div Cardiovasc Med, Fac Med & Hlth Sci, SE-58185 Linkoping, Sweden.
    Wågsäter, Dick
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Gender difference and genetic variance in lipoprotein receptor-related protein 1 is associated with mortality2019In: BIOMEDICAL REPORTS, ISSN 2049-9434, Vol. 11, no 1, p. 3-10Article in journal (Refereed)
    Abstract [en]

    Cardiovascular diseases are an important health resource problem and studies have shown a genetic association between single nucleotide polymorphisms (SNPs) and cardiovascular diseases. According to the literature, lipoprotein receptor-related protein 1 (LRP1) is associated with coronary artery disease. The aim of the present study was to evaluate a possible association between different genotypes of LRP1 and all-cause and cardiovascular mortality from a gender perspective. In the present study, 489 elderly community-living people were invited to participate. Clinical examination, echocardiography and blood sampling including SNP analyses of LRP1 (rs1466535) were performed, including the T/T, C/T and C/C genotypes, and the participants were followed for 6.7 years. During the follow-up period, 116 (24%) all-cause and 75 (15%) cardiovascular deaths were registered. In the female population, the LRP1 of the T/T or C/T genotype exhibited a 5.6-fold increased risk of cardiovascular mortality and a 2.8-fold increased risk of all-cause mortality compared with the C/C genotype. No such genotype differences could be seen in the male population. Gender differences could be seen regarding the risk of mortality in the different genotypes. Females with the LRP1 T/T or C/T genotypes exhibited a significantly increased risk of both all-cause and cardiovascular mortality compared with the C/C genotypes. Therefore, more individualized cardiovascular prevention and treatment should be prioritized. However, since this was a small study, the observations should only be regarded as hypothesis-generating.

  • 6296.
    Aleinov, I
    et al.
    Columbia Univ, Ctr Climate Syst Res, New York, NY 10027 USA;NASA, Goddard Inst Space Studies, New York, NY 10025 USA.
    Way, Michael J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy. NASA, Goddard Inst Space Studies, New York, NY 10025 USA; GSFC Sellers Exoplanet Environm Collaborat, Greenbelt, MD USA.
    Harman, C.
    NASA, Goddard Inst Space Studies, New York, NY 10025 USA;Columbia Univ, Dept Appl Phys & Appl Math, New York, NY USA.
    Tsigaridis, K.
    Columbia Univ, Ctr Climate Syst Res, New York, NY 10027 USA;NASA, Goddard Inst Space Studies, New York, NY 10025 USA.
    Wolf, E. T.
    Univ Colorado, Lab Atmospher & Space Phys, Boulder, CO 80309 USA.
    Gronoff, G.
    NASA, Sci Directorate, Chem & Dynam Branch, Langley Res Ctr, Hampton, VA USA;SSAI, Hampton, VA USA.
    Modeling a Transient Secondary Paleolunar Atmosphere: 3-D Simulations and Analysis2019In: Geophysical Research Letters, ISSN 0094-8276, E-ISSN 1944-8007, Vol. 46, no 10, p. 5107-5116Article in journal (Refereed)
    Abstract [en]

    The lunar history of water deposition, loss, and transport postaccretion has become an important consideration in relation to the possibility of a human outpost on the Moon. Very recent work has shown that a secondary primordial atmosphere of up to 10 mbar could have been emplaced similar to 3.5 x 10(9) years ago due to volcanic outgassing from the maria. Using a zero-dimensional chemistry model, we demonstrate the temperature dependence of the resulting major atmospheric components (CO or CO2). We use a three-dimensional general circulation model to test the viability of such an atmosphere and derive its climatological characteristics. Based on these results, we then conjecture on its capability to transport volatiles outgassed from the maria to the permanently shadowed regions at the poles. Our preliminary results demonstrate that atmospheres as low as 1 mbar are viable and that permanent cold trapping of volatiles is only possible at the poles.

  • 6297.
    Alekhin, A.
    et al.
    CNRS, Inst Mol & Mat Le Mans, UMR 6283, F-72085 Le Mans, France.
    Razdolski, I.
    CNRS, Inst Mol & Mat Le Mans, UMR 6283, F-72085 Le Mans, France;Max Planck Gesell, Fritz Haber Inst, D-14195 Berlin, Germany.
    Berritta, Marco
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Buerstel, D.
    Univ Duisburg Essen, Fac Chem, Univ Str 5, D-45141 Essen, Germany.
    Temnov, V.
    CNRS, Inst Mol & Mat Le Mans, UMR 6283, F-72085 Le Mans, France.
    Diesing, D.
    Univ Duisburg Essen, Fac Chem, Univ Str 5, D-45141 Essen, Germany.
    Bovensiepen, U.
    Univ Duisburg Essen, Fac Phys, Lotharstr 1, D-47057 Duisburg, Germany;Univ Duisburg Essen, Ctr Nanointegrat CENIDE, Lotharstr 1, D-47057 Duisburg, Germany.
    Woltersdorf, G.
    Martin Luther Univ Halle Wittenberg, Inst Phys, Von Danckelmann Pl 3, D-06120 Halle, Germany.
    Oppeneer, Peter M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Melnikov, A.
    Max Planck Gesell, Fritz Haber Inst, D-14195 Berlin, Germany;Martin Luther Univ Halle Wittenberg, Inst Phys, Von Danckelmann Pl 3, D-06120 Halle, Germany.
    Magneto-optical properties of Au upon the injection of hot spin-polarized electrons across Fe/Au(001) interfaces2019In: Journal of Physics: Condensed Matter, ISSN 0953-8984, E-ISSN 1361-648X, Vol. 31, no 12, article id 124002Article in journal (Refereed)
    Abstract [en]

    We demonstrate a novel method for the excitation of sizable magneto-optical effects in Au by means of the laser-induced injection of hot spin-polarized electrons in Au/Fe/MgO(001) heterostructures. It is based on the energy- and spin-dependent electron transmittance of Fe/Au interface which acts as a spin filter for non-thermalized electrons optically excited in Fe. We show that after crossing the interface, majority electrons propagate through the Au layer with the velocity on the order of 1 nm fs(-1) (close to the Fermi velocity) and the decay length on the order of 100nm. Featuring ultrafast functionality and requiring no strong external magnetic fields, spin injection results in a distinct magneto-optical response of Au. We develop a formalism based on the phase of the transient complex MOKE response and demonstrate its robustness in a plethora of experimental and theoretical MOKE studies on Au, including our ab initio calculations. Our work introduces a flexible tool to manipulate magneto-optical properties of metals on the femtosecond timescale that holds high potential for active magneto-photonics, plasmonics, and spintronics.

  • 6298.
    Aleklett, K
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Nuclear and Particle Physics.
    Survival of hot heavy nuclei.2001In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 221, p. 58-NUCL -Other (Other scientific)
  • 6299. Aleklett, K
    et al.
    Adelsköld, G
    Blomgren, J
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Neutron Research.
    Barrows, H
    Axelsson, R
    Problem-based learning in a distance course1998Report (Other (popular scientific, debate etc.))
  • 6300.
    Aleklett, Kjell
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Physics, Department of Nuclear and Particle Physics. Department of Physics and Astronomy, Nuclear Physics Researchers.
    Attempt to confirm superheavy element production in the 48Ca+238U reaction2005In: Physical Review C: Nuclear Physics, Vol. 72, no 1, p. 14605-1Article in journal (Refereed)
123124125126127128129 6251 - 6300 of 252572
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