uu.seUppsala universitets publikationer
Ändra sökning
Avgränsa sökresultatet
185186187188189 9351 - 9400 av 9432
RefereraExporteraLänk till träfflistan
Permanent länk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Träffar per sida
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sortering
  • Standard (Relevans)
  • Författare A-Ö
  • Författare Ö-A
  • Titel A-Ö
  • Titel Ö-A
  • Publikationstyp A-Ö
  • Publikationstyp Ö-A
  • Äldst först
  • Nyast först
  • Skapad (Äldst först)
  • Skapad (Nyast först)
  • Senast uppdaterad (Äldst först)
  • Senast uppdaterad (Nyast först)
  • Disputationsdatum (tidigaste först)
  • Disputationsdatum (senaste först)
  • Standard (Relevans)
  • Författare A-Ö
  • Författare Ö-A
  • Titel A-Ö
  • Titel Ö-A
  • Publikationstyp A-Ö
  • Publikationstyp Ö-A
  • Äldst först
  • Nyast först
  • Skapad (Äldst först)
  • Skapad (Nyast först)
  • Senast uppdaterad (Äldst först)
  • Senast uppdaterad (Nyast först)
  • Disputationsdatum (tidigaste först)
  • Disputationsdatum (senaste först)
Markera
Maxantalet träffar du kan exportera från sökgränssnittet är 250. Vid större uttag använd dig av utsökningar.
  • 9351. Zuev, Dmitry
    et al.
    Bravaya, Ksenia
    Crawford, T. Daniel
    Lindh, Roland
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för fysikalisk och analytisk kemi, Kvantkemi.
    Krylov, Anna I.
    Electronic structure of the two isomers of the anionic form of p-coumaric acid chromophore2011Ingår i: Journal of Chemical Physics, ISSN 0021-9606, E-ISSN 1089-7690, Vol. 134, nr 3, s. 034310-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A theoretical study of the electronic structure of the photoactive yellow protein (PYP) model chromophore, para-coumaric acid (p-CA), is presented. Electronically excited states of the phenolate and carboxylate isomers of the deprotonated p-CA are characterized by high-level ab initio methods including state-specific and multistate multireference pertrubation theory (SS-CASPT2, and MS-CASPT2), equation-of-motion coupled-cluster methods with single and double substitutions (EOM-CCSD) and with an approximate account of triple excitations (CC3). We found that the two isomers have distinctly different patterns of ionization and excitation energies. Their excitation energies differ by more than 1 eV, in contradiction to the experimental report [Rocha-Rinza et al., J. Phys. Chem. A 113, 9442 (2009)]. The calculations confirm metastable (autoionizing) character of the valence excited states of both phenolate and carboxylate isomers of p-CA in the gas phase. The type of resonance is different in the two forms. In the phenolate, the excited state lies above the detachment continuum (a shape resonance), whereas in the carboxylate the excited ππ* state lies below the π-orbital ionization continuum, but is above the states derived from ionization from three other orbitals (Feshbach resonance). The computed oscillator strength of the bright electronic state in the phenolate is higher than in the carboxylate, in agreement with Hückel's model predictions. The analysis of photofragmentation channels shows that the most probable products for the methylated derivatives of the phenolate and carboxylate forms of p-CA are CH3, CH2O and CH3, CH2O, CO2, respectively, thus suggesting an experimental probe that may discriminate between the two isomers.

  • 9352.
    Zukowski, Samual R.
    et al.
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
    Mitev, Pavlin D.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Strukturkemi.
    Hermansson, Kersti
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Strukturkemi.
    Ben-Amotz, Dor
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
    CO2 Hydration Shell Structure and Transformation2017Ingår i: Journal of Physical Chemistry Letters, ISSN 1948-7185, E-ISSN 1948-7185, Vol. 8, nr 13, s. 2971-2975Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The hydration-shell of CO2 is characterized using Raman multivariate curve resolution (Raman-MCR) spectroscopy combined with ab initio molecular dynamics (AIMD) vibrational density of states simulations, to validate our assignment of the experimentally observed high-frequency OH band to a weak hydrogen bond between water and CO2. Our results reveal that while the hydration-shell of CO2 is highly tetrahedral, it is also occasionally disrupted by the presence of entropically stabilized defects associated with the CO2-water hydrogen bond. Moreover, we find that the hydration-shell of CO2 undergoes a temperature-dependent structural transformation to a highly disordered (less tetrahedral) structure, reminiscent of the transformation that takes place at higher temperatures around much larger oily molecules. The biological significance of the CO2 hydration shell structural transformation is suggested by the fact that it takes place near physiological temperatures.

  • 9353.
    Zuleta, Marcelo
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Edvinsson, Tomas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Oorganisk kemi.
    Yu, Shun
    Ahmadi, Sareh
    Boschloo, Gerrit
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Göthelid, Mats
    Hagfeldt, Anders
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Light-induced rearrangements of chemisorbed dyes on anatase(101)2012Ingår i: Physical Chemistry, Chemical Physics - PCCP, ISSN 1463-9076, E-ISSN 1463-9084, Vol. 14, nr 30, s. 10780-10788Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Photoinduced molecular rearrangements are important in daily events essential for life such as visual perception and photo-protection of light harvesting complexes in plants. In this study we demonstrate that similar photoarrangements appear in an analogous technological application where the device performance is controlled by chromophores in sensitized anatase TiO2, one of the main components for light-harvesting in dye-sensitized solar cells (DSC). STM reveals that illumination leads to distortions of organic dyes containing conjugated backbones and of cis-bis(isothiocyanate)-bis-(2,2'-bipyridyl-4,4'-dicarboxylate)ruthenium(II)-bis(tetrabutylammonium), known as N719. The dyes were adsorbed in a closed-packed mode on an anatase(101) single crystal surface and imaged in the dark and under white light illumination in an ultra-high vacuum (UHV). STM images of N719 clearly suggest rearrangements caused by rotation of the dye. Conversely, organic dyes rearrange by photoisomerization depending on the number of double bonds, their position in the molecular structure and on the ligand modifications.

  • 9354.
    Zuleta, Marcelo
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för fysikalisk och analytisk kemi, Fysikalisk kemi.
    Yu, Shun
    Ahmadi, Sareh
    Boschloo, Gerrit
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för fysikalisk och analytisk kemi, Fysikalisk kemi.
    Göthelid, Mats
    Hagfeldt, Anders
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för fysikalisk och analytisk kemi, Fysikalisk kemi.
    Monitoring N719 Dye Configurations on (1 x n)-Reconstructed Anatase (100) by Means of STM: Reversible Configurational Changes upon Illumination2010Ingår i: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 26, nr 16, s. 13236-13244Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We report experimental results concerning the STM imaging of cis-bis (isothiocyanate)-bis-(2,2'-bipyridyl-4,4'dicarboxylate)ruthenium(II)bis( tetrabutylammonium) dye (known as N719) adsorbed on a single crystal of anatase TiO2(100). The cleaning pretreatment, by sputtering and annealing, of TiO2(100) yields a reproducible (1 x n) surface reconstruction. Previous to dye deposition, TiO2 was covered with one monolayer of 4-tert-butylpyridine (4-TBP) in ultrahigh vacuum (UHV) in order to protect the surface against air contamination. N719 was subsequently deposited by dipping the crystal into the dye solution. 4-TBP was removed partially in the solution and totally by heating the sample to around 285-300 degrees C in UHV. The images of the deposited 4-TBP on TiO2(100) revealed a complete surface coverage showing three modes of adsorption on TiO2. The relatively uncomplicated desorption of 4-TBP enables the accommodation and chemisorption of most N719 molecules directly onto the TiO2 surface. The STM imaging of N719 was affected, in a reversible way, by illumination, because the quality of the image changed after a few hours in the dark or under illumination conditions. The results presented herein are discussed in terms of changes in molecular configurations and in open circuit potentials.

  • 9355.
    Zuo, Shusheng
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för naturvetenskaplig biokemi.
    Quantitation, Purification and Reconstitution of the Red Blood Cell Glucose Transporter GLUT12005Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    The human glucose transporter GLUT1 facilitates glucose to be accumulated on the other side of the cell membrane. The functional state of GLUT1 is uncertain due to diversity of the reports. In this thesis, the activity of red blood cell GLUT1 was extensively studied to further characterize this protein.

    The human red blood cell membranes were stripped to become vesicles with low-ionic alkaline solution in the presence or absence of dithioerithritol. The supernatant of partially solubilized membrane vesicles provided approximately 65% of the vesicle proteins. GLUT1 purified from this supernatant showed a little high-affinity cytochalasin B binding activity. On the other hand, the vesicles stripped with dithioerythritol provided mostly monomeric GLUT1 and those without dithioerythritol provided monomeric and oligomeric GLUT1. MALDI-ToF-MS detected variant GLUT1 fragments between the two preparations. Residual endogenous phospholipids per GLUT1 also showed difference. However, the equilibrium exchange of glucose was retained for both GLUT1 preparations. Cytochalasin B-binding activity of GLUT1 in streptoavidin-biotin-immobilized red blood cells showed that both dissociation constant and binding sites per GLUT1 fell between those of wheat germ lectin-immobilized red blood cells with or without polylysine coating, which indicated the switching of two cytochalasin B-binding states of GLUT1. It is concluded that GLUT1 in red blood cells contains approximately two equal portions, monomeric with high-affinity cytochalasin B-binding activity and oligomeric without high-affinity cytochalasin B-binding activity. In the partial solubilization of the membrane vesicles, GLUT1 which does not have high-affinity cytochalasin B-binding activity is pooled. This might provide a resolution to select oligomerically and functionally different GLUT1 for crystallization.

    In addition a modified micro-Bradford assay with CaPE precipitation was developed to achieve a routine quantitation method for membrane proteins and the effects of cholesterol and PEG(5000)-DSPE on reconstituted GLUT1 were preliminarily determined.

    Delarbeten
    1. A Micro-Bradford Membrane Protein Assay
    Öppna denna publikation i ny flik eller fönster >>A Micro-Bradford Membrane Protein Assay
    2000 (Engelska)Ingår i: Analytical Biochemistry, ISSN 0003-2697, E-ISSN 1096-0309, Vol. 284, nr 1, s. 162-164Artikel i tidskrift (Refereegranskat) Published
    Nationell ämneskategori
    Naturvetenskap
    Identifikatorer
    urn:nbn:se:uu:diva-92798 (URN)10.1006/abio.2000.4676 (DOI)10933871 (PubMedID)
    Tillgänglig från: 2005-04-07 Skapad: 2005-04-07 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
    2. Conversion between two cytochalasin B-binding states of the human GLUT1 glucose transporter
    Öppna denna publikation i ny flik eller fönster >>Conversion between two cytochalasin B-binding states of the human GLUT1 glucose transporter
    Visa övriga...
    2000 (Engelska)Ingår i: European Journal of Biochemistry, ISSN 0014-2956, E-ISSN 1432-1033, Vol. 267, nr 23, s. 6875-6882Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Two cytochalasin B-binding states of the human red blood cell facilitative glucose transporter GLUT1 were studied, one exhibiting one cytochalasin B-binding site on every second GLUT1 monomer (state 1) and the other showing one site per monomer (state 2). Quantitative affinity chromatography of cytochalasin B was performed on (a) biotinylated red blood cells, (b) cytoskeleton-depleted red blood cell membrane vesicles, and (c) GLUT1 proteoliposomes. The cells were adsorbed on streptavidin-derivatized gel beads, and the vesicles and proteoliposomes entrapped in dextran-grafted agarose gel beads. Cytochalasin B binding to free vesicles and proteoliposomes was analyzed by Hummel and Dreyer size-exclusion chromatography and ultracentrifugation. Analysis of the biotinylated cells indicated an equilibrium between the two GLUT1 states. GLUT1 in free membrane vesicles attained state 2, but was converted into state 1 on entrapment of the vesicles. Purification of GLUT1 in the presence of non-ionic detergent followed by reconstitution produced GLUT1 in state 1. This state was maintained after entrapment of the proteoliposomes. Finally, GLUT1 showed slightly higher affinity for cytochalasin B in state 1 than in state 2. In summary, the cytochalasin B-binding state of GLUT1 seemed to be affected by (a) biotinylation of the cell surface, (b) removal of the cytoskeleton at high pH and low ionic strength, (c) interaction between the dextran-grafted agarose gel matrix and the membrane vesicles, and (d) reconstitution to form proteoliposomes.

    Nationell ämneskategori
    Naturvetenskap
    Identifikatorer
    urn:nbn:se:uu:diva-92799 (URN)10.1046/j.1432-1033.2000.01788.x (DOI)11082199 (PubMedID)
    Tillgänglig från: 2005-04-07 Skapad: 2005-04-07 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
    3. On the oligomeric state of the red blood cell glucose transporter GLUT1
    Öppna denna publikation i ny flik eller fönster >>On the oligomeric state of the red blood cell glucose transporter GLUT1
    2003 (Engelska)Ingår i: Biochimica et Biophysica Acta - Biomembranes, ISSN 0005-2736, E-ISSN 1879-2642, Vol. 1618, nr 1, s. 8-16Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    We stripped human red blood cell membranes of cytoskeleton proteins at pH 12 without reductant, partially solubilized the obtained vesicles by use of octaethylene glycol n-dodecyl ether and purified the glucose transporter GLUT1 by anion-exchange chromatography followed by sulfhydryl-affinity chromatography, which removed most of the nucleoside transporter (NT) and the lipids. Eighty percent of the sulfhydryl-bound GLUT1 could be eluted with sodium dodecyl sulfate (SDS) indicating that the bound protein was multimeric. Matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-ToF-MS) of the trypsinized major SDS-PAGE zone of the purified material identified GLUT1 but no other membrane protein. Transmembrane helices 1 and 8 were among the detected fragments. The reconstituted purified GLUT1 showed glucose transport activity, although only approximately 0.05 high-affinity cytochalasin B (CB) binding sites were present per GLUT1 monomer. The vesicles used as starting material for the purification showed 0.4 CB sites per GLUT1 monomer, similar to vesicles prepared in the presence of dithioerythritol. The data are consistent with the coexistence of monomeric GLUT1 with high-affinity CB-binding activity and preferentially solubilized multimeric GLUT1 with no CB-binding activity in the red blood cell membrane vesicles prepared without reductant.

    Nyckelord
    Chromatography; Affinity, Erythrocytes/*metabolism, Glucose/*metabolism, Glucose Transporter Type 1, Humans, Monosaccharide Transport Proteins/*chemistry/isolation & purification/metabolism, Protein Binding, Protein Conformation, Spectrometry; Mass; Matrix-Assisted Laser Desorption-Ionization, Structure-Activity Relationship
    Nationell ämneskategori
    Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
    Identifikatorer
    urn:nbn:se:uu:diva-92800 (URN)10.1016/j.bbamem.2003.10.001 (DOI)14643928 (PubMedID)
    Tillgänglig från: 2005-04-07 Skapad: 2005-04-07 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
    4. The effects of cholesterol and polyethyleneglycol phospholipids on the activities of the reconstituted human red blood cell glucose transporter GLUT1
    Öppna denna publikation i ny flik eller fönster >>The effects of cholesterol and polyethyleneglycol phospholipids on the activities of the reconstituted human red blood cell glucose transporter GLUT1
    Manuskript (Övrigt vetenskapligt)
    Identifikatorer
    urn:nbn:se:uu:diva-92801 (URN)
    Tillgänglig från: 2005-04-07 Skapad: 2005-04-07 Senast uppdaterad: 2010-01-13Bibliografiskt granskad
    5. Well-known sugar trasporters: The GLUT1 glucose transporter of human red blood cells and the glucose transporter and lactose permease of Escherichia coli
    Öppna denna publikation i ny flik eller fönster >>Well-known sugar trasporters: The GLUT1 glucose transporter of human red blood cells and the glucose transporter and lactose permease of Escherichia coli
    2002 (Engelska)Ingår i: Recent Research Developments in Biochemistry, Volym 3, Research Signpost, 2002, Vol. 3, s. 527-546Kapitel i bok, del av antologi (Refereegranskat)
    Ort, förlag, år, upplaga, sidor
    Research Signpost, 2002
    Nationell ämneskategori
    Naturvetenskap
    Identifikatorer
    urn:nbn:se:uu:diva-90676 (URN)81-7736-155-4 (ISBN)9788177361551 (ISBN)
    Tillgänglig från: 2003-09-04 Skapad: 2003-09-04 Senast uppdaterad: 2013-06-12Bibliografiskt granskad
  • 9356.
    Zuo, Shusheng
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för naturvetenskaplig biokemi.
    Hellman, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwiginstitutet för cancerforskning.
    Lundahl, Per
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för naturvetenskaplig biokemi.
    On the oligomeric state of the red blood cell glucose transporter GLUT12003Ingår i: Biochimica et Biophysica Acta - Biomembranes, ISSN 0005-2736, E-ISSN 1879-2642, Vol. 1618, nr 1, s. 8-16Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We stripped human red blood cell membranes of cytoskeleton proteins at pH 12 without reductant, partially solubilized the obtained vesicles by use of octaethylene glycol n-dodecyl ether and purified the glucose transporter GLUT1 by anion-exchange chromatography followed by sulfhydryl-affinity chromatography, which removed most of the nucleoside transporter (NT) and the lipids. Eighty percent of the sulfhydryl-bound GLUT1 could be eluted with sodium dodecyl sulfate (SDS) indicating that the bound protein was multimeric. Matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-ToF-MS) of the trypsinized major SDS-PAGE zone of the purified material identified GLUT1 but no other membrane protein. Transmembrane helices 1 and 8 were among the detected fragments. The reconstituted purified GLUT1 showed glucose transport activity, although only approximately 0.05 high-affinity cytochalasin B (CB) binding sites were present per GLUT1 monomer. The vesicles used as starting material for the purification showed 0.4 CB sites per GLUT1 monomer, similar to vesicles prepared in the presence of dithioerythritol. The data are consistent with the coexistence of monomeric GLUT1 with high-affinity CB-binding activity and preferentially solubilized multimeric GLUT1 with no CB-binding activity in the red blood cell membrane vesicles prepared without reductant.

  • 9357.
    Zuo, Shu-Sheng
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för naturvetenskaplig biokemi.
    Lagerquist Hägglund, Christine
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för naturvetenskaplig biokemi.
    Lundahl, Per
    Well-known sugar trasporters: The GLUT1 glucose transporter of human red blood cells and the glucose transporter and lactose permease of Escherichia coli2002Ingår i: Recent Research Developments in Biochemistry, Volym 3, Research Signpost, 2002, Vol. 3, s. 527-546Kapitel i bok, del av antologi (Refereegranskat)
  • 9358.
    Zuo, Shu-sheng
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för naturvetenskaplig biokemi.
    Lundahl, Per
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för naturvetenskaplig biokemi.
    A Micro-Bradford Membrane Protein Assay2000Ingår i: Analytical Biochemistry, ISSN 0003-2697, E-ISSN 1096-0309, Vol. 284, nr 1, s. 162-164Artikel i tidskrift (Refereegranskat)
  • 9359.
    Zuo, Shusheng
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för naturvetenskaplig biokemi.
    Lundahl, Per
    The effects of cholesterol and polyethyleneglycol phospholipids on the activities of the reconstituted human red blood cell glucose transporter GLUT1Manuskript (Övrigt vetenskapligt)
  • 9360. Zygelman, Bernard
    et al.
    Saenz, Alejandro
    Froelich, Piotr
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Fysiska institutionen. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kvantkemi. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för fysikalisk och analytisk kemi, Kvantkemi.
    Jonsell, Svante
    Cold Collisions of Atomic Hydrogen with Antihydrogen Atoms: an Optical Potential Approach2004Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics, ISSN 1050-2947, E-ISSN 1094-1622, Vol. 69, nr 4, s. 042715-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The non-adiabatic couplings between the ground state and the first 5 excited states in (HeT+)-He-3 have been calculated. Non-adiabatic corrections to the beta-decay spectrum of T-2 are derived in first-order perturbation theory. These corrections are esti

  • 9361. Zygelman, Bernard
    et al.
    Saenz, Alejandro
    Froelich, Piotr
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för fysikalisk och analytisk kemi, Kvantkemi.
    Jonsell, Svante
    Dalgarno, Alex
    Radiative association of atomic hydrogen with antihydrogen at sub-Kelvin temperatures2001Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics, ISSN 1050-2947, E-ISSN 1094-1622, Vol. 63, s. 052722-Artikel i tidskrift (Refereegranskat)
  • 9362. Zöttl, S.
    et al.
    Schöbel, H.
    Bartl, P.
    Leidlmair, C.
    Daxner, M.
    Denifl, S.
    Märk, T. D.
    Scheier, P.
    Spångberg, Daniel
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Strukturkemi.
    Mauracher, Andreas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Strukturkemi.
    Bohme, D. K.
    Energy harvesting in doped helium nano-droplets2012Ingår i: Journal of Physics, Conference Series, ISSN 1742-6588, E-ISSN 1742-6596, Vol. 388, nr 13, s. 132003-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We report the observation of sequential Penning ionization of dopants by metastable helium atoms in helium nano-droplets resulting in doubly charged ions. Strong charge induced dipole-interaction between the excited helium atom and the target ion provides a high probability for the transfer of the internal energy of the excited helium atom to the dopant ion. This process may also lead subsequently to a Coulomb explosion of molecular or cluster dopants.

  • 9363.
    Åberg, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Fysikalisk-kemiska institutionen, Avdelningen för kvantkemi.
    Open Quantum Systems: Effects in Interferometry, Quantum Computation, and Adiabatic Evolution2005Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    The effects of open system evolution on single particle interferometry, quantum computation, and the adiabatic approximation are investigated.

    Single particle interferometry: Three concepts concerning completely positive maps (CPMs) and trace preserving CPMs (channels), named subspace preserving (SP) CPMs, subspace local channels, and gluing of CPMs, are introduced. SP channels preserve probability weights on given orthogonal sum decompositions of the Hilbert space of a quantum system. Subspace locality determines what channels act locally with respect to such decompositions. Gluings are the possible total channels obtainable if two evolution devices, characterized by channels, act jointly on a superposition of a particle in their inputs. It is shown that gluings are not uniquely determined by the two channels. We determine all possible interference patterns in single particle interferometry for given channels acting in the interferometer paths. It is shown that the standard interferometric setup cannot distinguish all gluings, but a generalized setup can.

    Quantum computing: The robustness of local and global adiabatic quantum search subject to decoherence in the instantaneous eigenbasis of the search Hamiltonian, is examined. In both the global and local search case the asymptotic time-complexity of the ideal closed case is preserved, as long as the Hamiltonian dynamics is present. In the case of pure decoherence, where the environment monitors the search Hamiltonian, it is shown that the local adiabatic quantum search performs as the classical search with scaling N, and that the global search scales like N3/2 , where N is the list length. We consider success probabilities p<1 and prove bounds on the run-time with the same scaling as in the conditions for the p → 1 limit.

    Adiabatic evolution: We generalize the adiabatic approximation to the case of open quantum systems in the joint limit of slow change and weak open system disturbances.

    Delarbeten
    1. Subspace preservation, subspace locality, and gluing of completely positive maps
    Öppna denna publikation i ny flik eller fönster >>Subspace preservation, subspace locality, and gluing of completely positive maps
    2004 Ingår i: Annals of Physics, ISSN 0003-4916, Vol. 313, s. 326-367Artikel i tidskrift (Refereegranskat) Published
    Identifikatorer
    urn:nbn:se:uu:diva-93318 (URN)
    Tillgänglig från: 2005-09-01 Skapad: 2005-09-01Bibliografiskt granskad
    2. Operations and single-particle interferometry
    Öppna denna publikation i ny flik eller fönster >>Operations and single-particle interferometry
    2004 Ingår i: Physical Review A, ISSN 1050-2947, Vol. 70, s. 012103-Artikel i tidskrift (Refereegranskat) Published
    Identifikatorer
    urn:nbn:se:uu:diva-93319 (URN)
    Tillgänglig från: 2005-09-01 Skapad: 2005-09-01Bibliografiskt granskad
    3. Robustness of the adiabatic quantum search
    Öppna denna publikation i ny flik eller fönster >>Robustness of the adiabatic quantum search
    2005 (Engelska)Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics, ISSN 1050-2947, E-ISSN 1094-1622, Vol. 71, nr 6, s. 060312(R)-Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    The robustness of the local adiabatic quantum search to decoherence in the instantaneous eigenbasis of the search Hamiltonian is examined. We demonstrate that the asymptotic time complexity of the ideal closed case is preserved, as long as the Hamiltonian dynamics is present. In the special case of pure decoherence where the environment monitors the search Hamiltonian, it is shown that the local adiabatic quantum search performs as the classical search.

    Nyckelord
    Quantum computation, adiabatic quantum evolution, search algorithm
    Nationell ämneskategori
    Fysik
    Forskningsämne
    Fysik
    Identifikatorer
    urn:nbn:se:uu:diva-93320 (URN)10.1103/PhysRevA.71.060312 (DOI)000230275200013 ()
    Anmärkning
    Also in Virtual Journal of Nanoscale Science and Technology, July 11 issue 2005 and Virtual Journal of Quantum Information, July issue 2005.Tillgänglig från: 2005-09-01 Skapad: 2005-09-01 Senast uppdaterad: 2017-12-14
    4. Quantum adiabatic search with decoherence in the instantaneous energy eigenbasis
    Öppna denna publikation i ny flik eller fönster >>Quantum adiabatic search with decoherence in the instantaneous energy eigenbasis
    2005 (Engelska)Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics, ISSN 1050-2947, E-ISSN 1094-1622, Vol. 72, nr 4, s. 042317-Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    In Phys. Rev. A 71, 060312(R) (2005), the robustness of the local adiabatic quantum search to decoherence in the instantaneous eigenbasis of the search Hamiltonian was examined. We expand this analysis to include the case of the global adiabatic quantum search. As in the case of the local search the asymptotic time complexity for the global search is the same as for the ideal closed case, as long as the Hamiltonian dynamics is present. In the case of pure decoherence, where the environment monitors the search Hamiltonian, we find that the time complexity of the global quantum adiabatic search scales like N3∕2, where N is the list length. We moreover extend the analysis to include success probabilities p<1 and prove bounds on the run time with the same scaling as in the conditions for the p→1 limit. We supplement the analytical results by numerical simulations of the global and local search.

    Nyckelord
    Quantum computation, adiabatic approximation, search algorithm, open quantum systems
    Nationell ämneskategori
    Fysik
    Forskningsämne
    Fysik
    Identifikatorer
    urn:nbn:se:uu:diva-93321 (URN)10.1103/PhysRevA.72.042317 (DOI)000232931800051 ()
    Anmärkning
    Also in Virtual Journal of Nanoscale Science and Technology, October 31 issue 2005 and Virtual Journal of Quantum Information, November issue 2005. Tillgänglig från: 2005-09-01 Skapad: 2005-09-01 Senast uppdaterad: 2017-12-14
    5. Adiabatic approximation for weakly open systems
    Öppna denna publikation i ny flik eller fönster >>Adiabatic approximation for weakly open systems
    2005 (Engelska)Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics, ISSN 1050-2947, E-ISSN 1094-1622, Vol. A72, nr 022328, s. 022328-1-022328-13Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    We generalize the adiabatic approximation to the case of open quantum systems, in the joint limit of slow change and weak open system disturbances. We show that the approximation is “physically reasonable” as under wide conditions it leads to a completely positive evolution, if the original master equation can be written on a time-dependent Lindblad form. We demonstrate the approximation for a non-Abelian holonomic implementation of the Hadamard gate, disturbed by a decoherence process. We compare the resulting approximate evolution with numerical simulations of the exact equation.

    Nyckelord
    Adiabatic approximation, open quantum systems, quantum computation
    Nationell ämneskategori
    Fysik
    Forskningsämne
    Fysik
    Identifikatorer
    urn:nbn:se:uu:diva-93322 (URN)10.1103/PhysRevA.72.022328 (DOI)000231564200060 ()
    Tillgänglig från: 2005-09-01 Skapad: 2005-09-01 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
  • 9364.
    Åberg, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Fysikalisk-kemiska institutionen, Avdelningen för kvantkemi.
    Operations and single-particle interferometry2004Ingår i: Physical Review A, ISSN 1050-2947, Vol. 70, s. 012103-Artikel i tidskrift (Refereegranskat)
  • 9365.
    Åberg, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för kvantkemi. Kemiska sektionen, Institutionen för fysikalisk och analytisk kemi, Kvantkemi.
    Operations and single-particle interferometry2004Ingår i: Physical Review A, Vol. 70, s. 012103-Artikel i tidskrift (Refereegranskat)
  • 9366.
    Åberg, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Fysikalisk-kemiska institutionen, Avdelningen för kvantkemi.
    Subspace preservation, subspace locality, and gluing of completely positive maps2004Ingår i: Annals of Physics, ISSN 0003-4916, Vol. 313, s. 326-367Artikel i tidskrift (Refereegranskat)
  • 9367.
    Åberg, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för kvantkemi. Kemiska sektionen, Institutionen för fysikalisk och analytisk kemi, Kvantkemi.
    Subspace preservation, subspace locality, and gluing of completely positive maps2004Ingår i: Annals of Physics (N.Y.), Vol. 313, s. 326-Artikel i tidskrift (Refereegranskat)
  • 9368.
    Åberg, Ola
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Design and Synthesis of 11C-Labelled Compound Libraries for the Molecular Imaging of EGFr, VEGFr-2, AT1 and AT2 Receptors: Transition-Metal Mediated Carbonylations Using [11C]Carbon Monoxide2009Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    This work deals with radiochemistry and new approaches to develop novel PET tracers labelled with the radionuclide 11C.

    Two methods for the synthesis of 11C-labelled acrylamides have been explored. First, [1-11C]-acrylic acid was obtained from a palladium(0)-mediated 11C-carboxylation of acetylene with [11C]carbon monoxide; this could be converted to the corresponding acyl chloride and then combined with benzylamine to form N-benzyl[carbonyl-11C]acrylamide. In the second method, the palladium(0)-mediated carbonylation of vinyl halides with [11C]carbon monoxide was explored. This latter method, yielded labelled acrylamides in a single step with retention of configuration at the C=C double bond, and required less amine compared to the acetylene method.

    The vinyl halide method was used to synthesize a library of 11C-labelled EGFr-inhibitors in 7-61% decay corrected radiochemical yield via a combinatorial approach. The compounds were designed to target either the active or the inactive form of EGFr, following computational docking studies.

    The rhodium(I)-mediated carbonylative cross-coupling of an azide and an amine was shown to be a very general reaction and was used to synthesize a library of dual VEGFr-2/PDGFrβ inhibitors that were 11C-labelled at the urea position in 38-78% dc rcy.

    The angiotensin II AT1 receptor antagonist eprosartan was 11C-labelled at one of the carboxyl groups in one step using a palladium(0)-mediated carboxylation. Autoradiography shows specific binding in rat kidney, lung and adrenal cortex, and organ distribution shows a high accumulation in the intestines, kidneys and liver. Specific binding in frozen sections of human adrenal incidentalomas warrants further investigations of this tracer.

    Three angiotensin II AT2 ligands were 11C-labelled at the amide group in a palladium(0)-mediated aminocarbonylation in 16-36% dc rcy. One of the compounds was evaluated using in vitro using autoradiography, and in vivo using organ distribution and animal PET. The compound was metabolized fast and excreted via urine. High radioactivity was also found in the liver, meaning that more metabolically stable compounds are desirable for future development.

     

    Delarbeten
    1. Synthesis of [11C]/[13C]acrylamides by palladium-mediated carbonylation
    Öppna denna publikation i ny flik eller fönster >>Synthesis of [11C]/[13C]acrylamides by palladium-mediated carbonylation
    2007 (Engelska)Ingår i: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, nr 3, s. 455-461Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Two methods are presented for the synthesis of acrylamides labelled with C-11 (beta(+), t(1/2) = 20.4 min) and C-11 in the carbonyl position. In the first method, [1-C-11]acrylic acid is synthesised from [C-11]carbon monoxide by palladium-mediated hydroxy-carbonylation of acetylene. The labelled carboxylic acid is converted into the acyl chloride and subsequently treated with amine to yield N-benzyl[carbonyl(11)C]acrylamide, The second method utilizes [C-11]carbon monoxide in a palladium-mediated carbonylative cross-coupling of vinyl halides and amines. A higher radiochemical yield is achieved with the latter method and the amount of amine needed is decreased to 1/20. The C-11-labelled acrylamides were isolated in up to 81 % decay-corrected radiochemical yield. Starting from 10 +/- 0.5GBq of [C-11]carbon monoxide, N-benzyl[carbonyl-C-11]acrylamide was obtained in 4 min with a specific radioactivity of 330 +/- 4 GBq mu mol-(1). Co-labelling with C-11 and C-13 enabled confirmation of the labelled position by C-13 NMR spectroscopy.

    Nyckelord
    Carbonylation, Amides, Carbon monoxide, Isotopic labelling, Carbon-11, 11C, PET
    Nationell ämneskategori
    Kemi
    Forskningsämne
    Organisk kemi
    Identifikatorer
    urn:nbn:se:uu:diva-98592 (URN)10.1002/ejoc.200600700 (DOI)000243600100007 ()
    Tillgänglig från: 2009-02-27 Skapad: 2009-02-27 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
    2. Synthesis of a Library of 11C-Carbonyl-labelled Irreversibly Binding EGFr Inhibitors as Potential Biomarkers for Tumours
    Öppna denna publikation i ny flik eller fönster >>Synthesis of a Library of 11C-Carbonyl-labelled Irreversibly Binding EGFr Inhibitors as Potential Biomarkers for Tumours
    (Engelska)Manuskript (Övrigt vetenskapligt)
    Nyckelord
    [11C]carbon monoxide, isotopic labelling, EGFR, molecular imaging, PET, kinase, acrylamide
    Nationell ämneskategori
    Organisk kemi
    Forskningsämne
    Organisk kemi; Organisk farmaceutisk kemi
    Identifikatorer
    urn:nbn:se:uu:diva-98596 (URN)
    Tillgänglig från: 2009-03-04 Skapad: 2009-02-27 Senast uppdaterad: 2013-10-02
    3. Rhodium-mediated [11C]Carbonylation: A library of N-phenyl-N′-{4-(4-quinolyloxy)-phenyl}-[11C]-urea derivatives as potential PET angiogenic probes
    Öppna denna publikation i ny flik eller fönster >>Rhodium-mediated [11C]Carbonylation: A library of N-phenyl-N′-{4-(4-quinolyloxy)-phenyl}-[11C]-urea derivatives as potential PET angiogenic probes
    2009 (Engelska)Ingår i: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 52, nr 5, s. 151-157Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    As part of our ongoing investigation into the imaging of angiogenic processes, a small library of eight vascular endothelial growth factor receptor-2 (VEGFR-2)/platelet-derived growth factor receptor beta dual inhibitors based on the N-phenyl-N'-4-(4-quinolyloxy)-phenyl-urea was labelled with C-11 (beta(+), t(1/2) = 20.4 min) in the urea carbonyl position via rhodium-mediated carbonylative cross-coupling of an aryl azide and different anilines. The decay-corrected radiochemical yields of the isolated products were in the range of 38-81% calculated from [C-11]carbon monoxide. Starting with 10.7+/-0.5 GBq of [C-11]carbon monoxide, 1-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluoro-phenyl]-3-(4-fluoro-phenyl)-[C-11]-urea (2.1 GBq) was isolated after total reaction time of 45 min with a specific activity of 92+/-4 GBq mu mol(-1).

    Nyckelord
    carbonylation, carbon-11, 11C, angiogenesis, VEGFR-2, PET, kinase
    Nationell ämneskategori
    Organisk kemi
    Forskningsämne
    Organisk kemi; Organisk farmaceutisk kemi
    Identifikatorer
    urn:nbn:se:uu:diva-98593 (URN)10.1002/jlcr.1582 (DOI)000267243600003 ()
    Tillgänglig från: 2009-02-27 Skapad: 2009-02-27 Senast uppdaterad: 2017-12-13
    4. Synthesis of Asymmetric [11C]Ureas and [11C]Sulphonylureas by Rh(I)-Mediated Carbonylation
    Öppna denna publikation i ny flik eller fönster >>Synthesis of Asymmetric [11C]Ureas and [11C]Sulphonylureas by Rh(I)-Mediated Carbonylation
    (Engelska)Manuskript (Övrigt vetenskapligt)
    Nyckelord
    [11C]carbon monoxide, urea, sulfonurea, tolbutamide, isotopic labelling, 11C, carbon-11
    Nationell ämneskategori
    Organisk kemi
    Forskningsämne
    Organisk kemi
    Identifikatorer
    urn:nbn:se:uu:diva-98598 (URN)
    Tillgänglig från: 2009-03-05 Skapad: 2009-02-27 Senast uppdaterad: 2013-10-02
    5. Synthesis and Biological Evaluation of [Carboxyl-11C]eprosartan
    Öppna denna publikation i ny flik eller fönster >>Synthesis and Biological Evaluation of [Carboxyl-11C]eprosartan
    Visa övriga...
    2009 (Engelska)Ingår i: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 52, nr 8, s. 295-303Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Essential hypertension occurs in approximately 25% of the adult population and one cause of hypertension is primary aldosteronism. Targeting the angiotensin II AT1 receptor using PET and an appropriate tracer may offer a diagnostic method for adrenocortical tissue. This report describes the synthesis of the selective AT1 receptor antagonist [carboxyl-11C]eprosartan 10, 4-[2-butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-[carboxyl-11C]benzoic acid, and its precursor (E)-3-[2-butyl-3-(4-iodo-benzyl)-3H-imidazol-4-yl]-2-thiophen-2-ylmethyl-acrylic acid 9. 11C-carboxylation of the iodobenzyl moiety was performed using a palladium-mediated reaction with [11C]carbon monoxide in the presence of tetra-n-butyl-ammonium hydroxide in a micro-autoclave using a temperature gradient from 25 to 140°C over 5 min. After purification by semipreparative HPLC, [carboxyl-11C]eprosartan 10 was obtained in 37–54% decay-corrected radiochemical yield (from [11C]carbon monoxide) with a radiochemical purity >95% within 35 min of the end of bombardment (EOB). A 5-µAh bombardment gave 2.04 GBq of 10 (50% rcy from [11C]carbon monoxide) with a specific activity of 160 GBq µmol−1 at 34 min after EOB. Frozen-section autoradiography shows specific binding in kidney, lung and adrenal cortex. In vivo experiments in rats demonstrate a high accumulation in kidney, liver and intestinal wall.

    Nyckelord
    angiotensin II, AT1, eprosartan, [11C]carbon monoxide, carboxylation, isotopic labelling, 11C, PET
    Nationell ämneskategori
    Organisk kemi
    Forskningsämne
    Organisk farmaceutisk kemi; Organisk kemi
    Identifikatorer
    urn:nbn:se:uu:diva-98594 (URN)10.1002/jlcr.1598 (DOI)000268690300032 ()
    Tillgänglig från: 2009-02-27 Skapad: 2009-02-27 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
    6. Synthesis and evaluation of a 11C-labelled angiotensin II AT2 receptor ligand
    Öppna denna publikation i ny flik eller fönster >>Synthesis and evaluation of a 11C-labelled angiotensin II AT2 receptor ligand
    Visa övriga...
    2010 (Engelska)Ingår i: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 53, nr 10, s. 616-624Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Three C-11-radiolabelled high-affinity nonpeptide AT(2) receptor-selective ligands were synthesized and one of these was evaluated as positron emission tomography (PET) tracer. The labelling reaction was performed via palladium(0)-mediated aminocarbonylation of the aryl iodide substrate using [C-11] carbon monoxide as the labelled precursor. As an example, starting with 10.0 GBq [C-11] carbon monoxide, 1.10 GBq of the product N-butoxycarbonyl-3-[4-(N-benzyl-[C-11] carbamoyl)phenyl]-5-isobutylthiophene-2-sulphonamide [C-11]4d was obtained in 36% decay-corrected radiochemical yield (from [C-11] carbon monoxide), 42 min from end of bombardment with a specific activity of 110 GBq.mu mol(-1). The N-isopropyl-[C-11] carbamoyl-analogue [C-11]4c (radiochemical purity >95%) was studied employing autoradiography, organ distribution, and small animal PET. In vitro autoradiography showed specific binding in the pancreas and kidney. Organ distribution in six rats revealed a high uptake in the liver, intestine, kidney, and adrenals. Small animal PET showed rapid and reversible uptake in the kidneys followed by accumulation in the urinary bladder suggesting fast renal excretion of the tracer. In addition, high accumulation was also seen in the liver. For future studies, more metabolically stable tracers will need to be developed. To the best of our knowledge, this is the first attempt of the use of PET imaging for the detection of expressed, fully functional AT(2) receptors in living subjects.

    Nyckelord
    angiotensin II, AT2, PET, 11C, aminocarbonylation, [11C]carbon monoxide
    Nationell ämneskategori
    Organisk kemi
    Forskningsämne
    Organisk kemi
    Identifikatorer
    urn:nbn:se:uu:diva-98914 (URN)10.1002/jlcr.1793 (DOI)000282667600004 ()
    Tillgänglig från: 2009-03-05 Skapad: 2009-03-05 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
    7. Synthesis of the Aryl Iodide Precursor of [Carboxyl-11C]Candesartan
    Öppna denna publikation i ny flik eller fönster >>Synthesis of the Aryl Iodide Precursor of [Carboxyl-11C]Candesartan
    (Engelska)Manuskript (Övrigt vetenskapligt)
    Nationell ämneskategori
    Organisk kemi
    Forskningsämne
    Oorganisk kemi; Organisk farmaceutisk kemi
    Identifikatorer
    urn:nbn:se:uu:diva-98597 (URN)
    Tillgänglig från: 2009-03-04 Skapad: 2009-02-27 Senast uppdaterad: 2013-10-02
  • 9369.
    Åberg, Ola
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Kihlberg, Tor
    Uppsala Imanet, GE Healthcare.
    Långström, Bengt
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Synthesis of the Aryl Iodide Precursor of [Carboxyl-11C]CandesartanManuskript (Övrigt vetenskapligt)
  • 9370.
    Åberg, Ola
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Lindhe, Örjan
    Uppsala Imanet, GE Healhcare.
    Hall, Håkan
    Uppsala ASL, GE .
    Hellman, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Endokrinkirurgi.
    Kihlberg, Tor
    Uppsala Imanet, GE Healthcare.
    Bengt, Långström
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Synthesis and Biological Evaluation of [Carboxyl-11C]eprosartan2009Ingår i: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 52, nr 8, s. 295-303Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Essential hypertension occurs in approximately 25% of the adult population and one cause of hypertension is primary aldosteronism. Targeting the angiotensin II AT1 receptor using PET and an appropriate tracer may offer a diagnostic method for adrenocortical tissue. This report describes the synthesis of the selective AT1 receptor antagonist [carboxyl-11C]eprosartan 10, 4-[2-butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-[carboxyl-11C]benzoic acid, and its precursor (E)-3-[2-butyl-3-(4-iodo-benzyl)-3H-imidazol-4-yl]-2-thiophen-2-ylmethyl-acrylic acid 9. 11C-carboxylation of the iodobenzyl moiety was performed using a palladium-mediated reaction with [11C]carbon monoxide in the presence of tetra-n-butyl-ammonium hydroxide in a micro-autoclave using a temperature gradient from 25 to 140°C over 5 min. After purification by semipreparative HPLC, [carboxyl-11C]eprosartan 10 was obtained in 37–54% decay-corrected radiochemical yield (from [11C]carbon monoxide) with a radiochemical purity >95% within 35 min of the end of bombardment (EOB). A 5-µAh bombardment gave 2.04 GBq of 10 (50% rcy from [11C]carbon monoxide) with a specific activity of 160 GBq µmol−1 at 34 min after EOB. Frozen-section autoradiography shows specific binding in kidney, lung and adrenal cortex. In vivo experiments in rats demonstrate a high accumulation in kidney, liver and intestinal wall.

  • 9371.
    Åberg, Ola
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Plattformen för preklinisk PET.
    Långström, Bengt
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Fysikalisk-organisk kemi.
    Combinatorial synthesis of labelled drugs and PET tracers: synthesis of a focused library of 11C-carbonyl-labelled acrylamides as potential biomarkers of EGFR expression2012Ingår i: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 55, nr 14, s. 477-483Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Combinatorial synthesis is extensively used in drug development and lead optimisation. However, this approach has rarely been used for positron emission tomography because of limitations in available technologies. [11C]Carbon monoxide is amenable to combinatorial synthesis in transition-metal-catalysed reactions because it can react with a wide variety of electrophiles and nucleophiles, which opens up the possibilities for combinatorial radiochemistry. Herein, we exemplify the combinatorial approach by 11C-labelling a library of epidermal growth factor receptor inhibitors. The selection of candidates was guided by molecular docking. Epidermal growth factor receptor is overexpressed in a variety of tumours, and it has become an important drug target. The 11C-labelling reactions were performed using four substituted vinyl iodides and three different 4-anilino-6-aminoquinazolines using a palladium-mediated reaction with [11C]carbon monoxide using a single set of reaction conditions. In total, 12 labelled acrylamide derivatives were radiolabelled and obtained in 24–61% decay-corrected radiochemical yield (from [11C]carbon monoxide). Starting from 5.6 GBq [11C]carbon monoxide, 0.85 GBq of formulated N-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acryl[11C]amide [11C]12da was obtained within 47 min from end of bombardment (specific activity of 60 GBq µmol−1). This strategy is an example of how [11C]carbon monoxide can be utilised in the labelling of libraries of drug candidates and positron emission tomography tracers for in vitro and in vivo testing.

  • 9372.
    Åberg, Ola
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Långström, Bengt
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Synthesis of a Library of 11C-Carbonyl-labelled Irreversibly Binding EGFr Inhibitors as Potential Biomarkers for TumoursManuskript (Övrigt vetenskapligt)
  • 9373.
    Åberg, Ola
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Långström, Bengt
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Synthesis of Asymmetric [11C]Ureas and [11C]Sulphonylureas by Rh(I)-Mediated CarbonylationManuskript (Övrigt vetenskapligt)
  • 9374.
    Åberg, Ola
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Långström, Bengt
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Synthesis of substituted [C-11]ureas and [C-11]sulphonylureas by Rh(I)-mediated carbonylation2011Ingår i: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 54, nr 1, s. 38-42Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The urea moiety is present in many biologically active compounds and thus an attractive target for C-11-labelling. To extend the scope of the rhodium(I)-mediated carbonylative cross-coupling reaction between an azide and an amine and investigate its tolerance for functional groups, we have synthesized eight ureas and two sulphonylureas that were C-11-labelled in the carbonyl position. The decay-corrected analytical radiochemical yields were in the range of 14-96% (from [C-11] carbon monoxide). For example: starting from 1.33 GBq [C-11] carbon monoxide, 0.237 GBq (66%) of the cytotoxic sulphonylurea [C-11] LY-181984 11 was isolated within 60 min from end of bombardment. The mild reaction conditions and generality regarding functional groups of this method make it an attractive alternative to the [C-11] phosgene method for the synthesis of C-11-labelled ureas.

  • 9375.
    Åberg, Ola
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Stevens, Marc
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Avdelningen för organisk farmaceutisk kemi.
    Lindh, Jonas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Avdelningen för organisk farmaceutisk kemi. ORGFARM.
    Wallinder, Charlotta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Avdelningen för organisk farmaceutisk kemi.
    Hall, Håkan
    Monazzam, Azita
    Uppsala Imanet, GE Healthcare.
    Larhed, Mats
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Avdelningen för organisk farmaceutisk kemi.
    Långström, Bengt
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
    Synthesis and evaluation of a 11C-labelled angiotensin II AT2 receptor ligand2010Ingår i: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 53, nr 10, s. 616-624Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Three C-11-radiolabelled high-affinity nonpeptide AT(2) receptor-selective ligands were synthesized and one of these was evaluated as positron emission tomography (PET) tracer. The labelling reaction was performed via palladium(0)-mediated aminocarbonylation of the aryl iodide substrate using [C-11] carbon monoxide as the labelled precursor. As an example, starting with 10.0 GBq [C-11] carbon monoxide, 1.10 GBq of the product N-butoxycarbonyl-3-[4-(N-benzyl-[C-11] carbamoyl)phenyl]-5-isobutylthiophene-2-sulphonamide [C-11]4d was obtained in 36% decay-corrected radiochemical yield (from [C-11] carbon monoxide), 42 min from end of bombardment with a specific activity of 110 GBq.mu mol(-1). The N-isopropyl-[C-11] carbamoyl-analogue [C-11]4c (radiochemical purity >95%) was studied employing autoradiography, organ distribution, and small animal PET. In vitro autoradiography showed specific binding in the pancreas and kidney. Organ distribution in six rats revealed a high uptake in the liver, intestine, kidney, and adrenals. Small animal PET showed rapid and reversible uptake in the kidneys followed by accumulation in the urinary bladder suggesting fast renal excretion of the tracer. In addition, high accumulation was also seen in the liver. For future studies, more metabolically stable tracers will need to be developed. To the best of our knowledge, this is the first attempt of the use of PET imaging for the detection of expressed, fully functional AT(2) receptors in living subjects.

  • 9376.
    Åhlund, John
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Fysiska institutionen, Fysik V.
    Nilson, Katharina
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Fysiska institutionen, Fysik V.
    Schiessling, Joachim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Fysiska institutionen, Fysik V.
    Kjeldgaard, Lisbeth
    Berner, Simon
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för ytbioteknik med Centrum för ytbioteknik. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Fysiska institutionen, Fysik V.
    Mårtensson, Nils
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Fysiska institutionen, Fysik V.
    Puglia, Carla
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Fysiska institutionen, Fysik V.
    Brena, Barbara
    Nyberg, Mats
    Luo, Yi
    The electronic structure of iron phthalocyanine probed by photoelectron and x-ray absorption spectroscopies and density functional theory calculations2006Ingår i: Journal of Chemical Physics, ISSN 0021-9606, E-ISSN 1089-7690, ISSN 0021-9606, Vol. 125, nr 3, s. 34709-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A joint experimental and theoretical work to explain the electronic and geometrical structure of anin situ prepared film of iron phthalocyanine FePc on silicon 100 is presented. FePc molecularfilms have been characterized by core and valence photoemission spectroscopy PES and x-rayabsorption spectroscopy XAS, and the results have been interpreted and simulated by densityfunctional theory DFT calculations. C1s and N1s PE spectra have been analyzed by taking intoaccount all chemically nonequivalent C and N atoms in the molecule. In the Fe2p3/2 spectra it hasbeen possible to resolve two components that can be related to the open shell structure of themolecule. By valence PES and N1s XAS data, the geometrical orientation of the FePc molecules inthe film could be determined. Our results indicate that for the FePc on Si100, the molecules withinthe film are mainly standing on the surface. The experimental N1s XAS spectra are very wellreproduced by the theoretical calculations, which are both angle and atomic resolved, giving adetailed description of the electronic and geometric structure of the FePc film. Furthermore, theasymmetry and the intensity angle variation of the first N1s XAS threshold feature could beexplained by the presented DFT calculations as due to the chemical nonequivalence of the N atomsand the symmetry character of the lowest unoccupied molecular orbital. © 2006 American Instituteof Physics.

  • 9377.
    Åkerlund, Lisa
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Emanuelsson, Rikard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Gogoll, Adolf
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC.
    Strömme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Sjödin, Martin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Quinone based Conducting Redox Polymers for Renewable Energy Storage2016Konferensbidrag (Refereegranskat)
    Abstract [en]

    To meet future energy needs and to minimize CO2-emissions, a higher share of produced electricity must come from renewable resources [1]. Unfortunately, the output of renewable energy sources varies and does not always correlate with the temporal demand for electricity. For this reason, high capacity electrical energy storage (EES) is needed to fully utilize renewable energy sources [2]. Today’s battery technologies primarily rely on metals extracted at large economic and environmental costs [3],and the benefits of converting to carbon based materials are several, e.g. lower weight, flexible materials, and better recycling possibilities. In addition, the total energy consumption in the production chain may be reduced if the high temperatures required for extracting and processing metals can be avoided. Conducting redox polymers (CRPs), i.e. conducting polymers with redox active side groups, are currently investigated as possible organic electrode materials [4]. In this work we focus on finding stable side groups with high charge storage capacity. Quinones, which occur in natural energy conversion systems, i.e. during photosynthesis and respiration, are an attractive side group for CRPs due to their high gravimetric capacity. Importantly, for a functioning battery application the redox group and the polymer backbone must be active in the same potential window and this can be tuned effectively over a wide potential range by substitution on the quinone ring; hence various quinone derivatives could match different polymer backbones. A high potential- and high charge capacity quinone derivative has been synthesized and electrochemically characterized with the aim of producing a novel CRP to function as an organic high charge capacity material, targeting renewable organic batteries for a future of sustainable EES.

     

    References

    [1]  D. Larcher, J. M. Tarascon,, Nat. Chem. 7 (2015) 19-29.

    [2] Z. Yang, J. Zhang, M. C. W. Kintner-Meyer, X. Lu, D. Choi, J. P. Lemmon, J. Liu, Chem. Rev. 111 (2011) 3577–3613.

    [3] P. Poizot, F. Dolhem, Energy Environ. Sci. 4 (2011) 2003-2019.

    [4] (a) C. Karlsson, H. Huang, M. Stromme, A. Gogoll, M. Sjodin, RSC Adv. 5 (2015) 11309-11316; (b) C. Karlsson, H. Huang, M. Stromme, A. Gogoll, M. Sjodin, Electrochim. Acta 179 (2015) 336-342.

    [5] L. Åkerlund, R. Emanuelsson, A. Gogoll, M. Strömme, M. Sjödin, To be submitted.

  • 9378.
    Åkerlund, Lisa
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Emanuelsson, Rikard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Gogoll, Adolf
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Sjödin, Martin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Organic Materials for Renewable Energy Storage2016Konferensbidrag (Refereegranskat)
  • 9379.
    Åkerlund, Lisa
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Emanuelsson, Rikard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Gogoll, Adolf
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC.
    Strømme, Maria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Sjödin, Martin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
    Quinone based Conducting Redox Polymers for Renewable Energy Storage2016Konferensbidrag (Refereegranskat)
    Abstract [en]

    To meet future energy needs and to minimize CO2-emissions, a higher share of produced electricity must come from renewable resources [1]. Unfortunately, the output of renewable energy sources varies and does not always correlate with the temporal demand for electricity. For this reason, high capacity electrical energy storage (EES) is needed to fully utilize renewable energy sources [2]. Today’s battery technologies primarily rely on metals extracted at large economic and environmental costs [3],and the benefits of converting to carbon based materials are several, e.g. lower weight, flexible materials, and better recycling possibilities. In addition, the total energy consumption in the production chain may be reduced if the high temperatures required for extracting and processing metals can be avoided. Conducting redox polymers (CRPs), i.e. conducting polymers with redox active side groups, are currently investigated as possible organic electrode materials [4]. In this work we focus on finding stable side groups with high charge storage capacity. Quinones, which occur in natural energy conversion systems, i.e. during photosynthesis and respiration, are an attractive side group for CRPs due to their high gravimetric capacity. Importantly, for a functioning battery application the redox group and the polymer backbone must be active in the same potential window and this can be tuned effectively over a wide potential range by substitution on the quinone ring; hence various quinone derivatives could match different polymer backbones. A high potential- and high charge capacity quinone derivative has been synthesized and electrochemically characterized with the aim of producing a novel CRP to function as an organic high charge capacity material, targeting renewable organic batteries for a future of sustainable EES.

     

    References

    [1]  D. Larcher, J. M. Tarascon,, Nat. Chem. 7 (2015) 19-29.

    [2] Z. Yang, J. Zhang, M. C. W. Kintner-Meyer, X. Lu, D. Choi, J. P. Lemmon, J. Liu, Chem. Rev. 111 (2011) 3577–3613.

    [3] P. Poizot, F. Dolhem, Energy Environ. Sci. 4 (2011) 2003-2019.

    [4] (a) C. Karlsson, H. Huang, M. Stromme, A. Gogoll, M. Sjodin, RSC Adv. 5 (2015) 11309-11316; (b) C. Karlsson, H. Huang, M. Stromme, A. Gogoll, M. Sjodin, Electrochim. Acta 179 (2015) 336-342.

    [5] L. Åkerlund, R. Emanuelsson, A. Gogoll, M. Strömme, M. Sjödin, To be submitted.

  • 9380.
    Åkerlund, Lisa