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  • 1.
    Aramesh, Frida
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Engelska i klassrummet och på fritiden.: En kvantitativ och kvalitativ studie om elevers och lärares perspektiv på språkängslan i det engelska språket.2018Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 2.
    Emma, Åhrberg
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Vilka är samerna? En analys av läroböcker i årskurs 1-62018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 3.
    Garshasebi, Amanda
    Uppsala University, Uppsala University Innovation (UU Innovation). Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Leka bör man annars dör man: En studie om hur förskollärare arbetar på lekterapin på sjukhus2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 4.
    Gould, Victoria J.
    et al.
    Cardiff Metropolitan University, Cardiff, Wales, Great Britain.
    Evans, Ellen W
    Cardiff Metropolitan University, Cardiff, Wales, Great Britain.
    Redmond, Elizabeth C
    Cardiff Metropolitan University, Cardiff, Wales, Great Britain.
    Marklinder, Ingela M
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Quinlan, Jennifer J
    Drexel University, Philadelphia, USA.
    Ilic, Sanja
    The Ohio State University, Columbus, USA.
    Exploring the Role of Dietitians in the delivery of Food safety Information2019In: Food Protection Trends, p. 277-282Article in journal (Refereed)
  • 5.
    Johannesson, Pontus
    et al.
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Nilsson, Alexander
    Skola eller särskola?: ”Då är det kört, då är han eller hon utvecklingsstörd”2018Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 6.
    Kjaergaard, Marina
    et al.
    Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, DK-1870 Frederiksberg C, Denmark;Novo Nordisk AS, Diabet & Obes Res, DK-2760 Malov, Denmark.
    Nilsson, Cecilia
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Nielsen, Mette Olaf
    Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, DK-1870 Frederiksberg C, Denmark.
    Grove, Kevin
    Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Diabet Obes & Metab, Beaverton, OR 97006 USA;Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Reprod & Dev Sci, Beaverton, OR 97006 USA;Novo Nordisk AS, Diabet & Obes Res, DK-2760 Malov, Denmark.
    Raun, Kirsten
    Novo Nordisk AS, Diabet & Obes Res, DK-2760 Malov, Denmark.
    Hypothalamic Oxidative stress and inflammation, and peripheral glucose homeostasis in Sprague-Dawley rat offspring exposed to maternal and postnatal chocolate and soft drink2018In: Nutrition & Diabetes, ISSN 2044-4052, E-ISSN 2044-4052, Vol. 8, article id 44Article in journal (Refereed)
    Abstract [en]

    Background: Predisposition to obesity and type 2 diabetes can arise during foetal development and in early postnatal life caused by imbalances in maternal nutritional overload. We aimed to investigate the effects of maternal and postnatal intake of chocolate and soft drink on hypothalamic anti-oxidative stress markers, inflammation and peripheral glucose homeostasis. Methods: Pregnant Sprague-Dawley rats were fed ad libitum chow diet only (C) or with chocolate and high sucrose soft drink supplements (S). At birth, litter size was adjusted into 10 male offspring per dam. After weaning at 3 weeks of age, offspring from both dietary groups were assigned to either S or C diet, giving four groups until the end of the experiment at 26 weeks of age. Results: Offspring exposed to maternal S had up-regulated hypothalamic anti-oxidative markers such as SOD2 and catalase at 3 weeks of age as an indication of oxidative stress. However, at 12 weeks of age these anti-oxidative markers tended to decrease while pro-inflammatory markers such as TNF and IL-1 beta became up-regulated of all offspring exposed to S diet during some point of their life. Thus, despite an increase in anti-oxidative stress response, offspring exposed to maternal S had a reduced ability to counteract hypothalamic inflammation. At the same time point, postnatal S resulted in increased adiposity, reduced glucose tolerance and insulin sensitivity with no effect on body weight. However, at 25 weeks of age, the impaired glucose tolerance was reversible to the response of the control regardless of increased adiposity and body weight pointing towards a compensatory response of the insulin sensitivity or insulin secretion. Conclusion: Indications of hypothalamic oxidative stress was observed prior to the inflammatory response in offspring exposed to maternal S. Both maternal and postnatal S induced hypothalamic inflammation prior to increased weight gain and thus contributing to obese phenotype.

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