Logo: to the web site of Uppsala University

uu.sePublications from Uppsala University
Change search
Link to record
Permanent link

Direct link
Lindquist, Olle
Publications (5 of 5) Show all publications
Nilsson, K., Lukinius, A., Påhlson, C., Moron, C., Hajem, N., Olsson, B. & Lindquist, O. (2005). Evidence of Rickettsia spp. infection in Sweden: a clinical, ultrastructural and serological study. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 113(2), 126-134
Open this publication in new window or tab >>Evidence of Rickettsia spp. infection in Sweden: a clinical, ultrastructural and serological study
Show others...
2005 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 113, no 2, p. 126-134Article in journal (Refereed) Published
Abstract [en]

Sweden is an area potentially endemic for spotted fever rickettsioses. Rickettsia helvetica has been isolated from its tick vector Ixodes Ricinus, and in a handful of cases linked to human disease. This study demonstrates for the first time in Sweden the transmission of rickettsial infection after a tick bite and the attack rate in an endemic area. We present three cases of documented rickettsial infection and a prospective serological study of Swedish recruits who were trained in the area where the patients lived and showed seroconversion to spotted fever rickettsiae. All patients showed a four-fold increas in antibody titer to the spotted fever rickettsia, R. helvetica, and immunohistochemical examination revealed rickettsia-like organisms in the walls of skin capillaries and veins. Electron microscopy showed organisms resembling R. helvetica and immunogold labeling with two anti-rickettsial antibodies demonstrated specific labeling of the rickettsial organisms in the skin biopsy specimens. Eight of the thirty-five recruits showed a four-fold increase in IgG titer reflecting a high rate of exposure. The results of this study demonstrate that spotted fever rickettsioses should be taken into consideration in the diagnosis of tick-transmitted infections in Sweden.

Keywords
Rickettsiosis, serology, ultrastructure, tick, Rickettsios, serologi, ultrastruktur, fästingar
National Category
Dermatology and Venereal Diseases
Identifiers
urn:nbn:se:uu:diva-72248 (URN)10.1111/j.1600-0463.2005.apm1130206.x (DOI)15723687 (PubMedID)
Available from: 2006-06-22 Created: 2006-06-22 Last updated: 2017-12-14Bibliographically approved
McGill, S., Rajs, J., Hjelm, E., Lindquist, O. & Friman, G. (2003). A study on forensic samples of Bartonella spp. antibodies in Swedish intravenous heroin addicts. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 111(4), 507-513
Open this publication in new window or tab >>A study on forensic samples of Bartonella spp. antibodies in Swedish intravenous heroin addicts
Show others...
2003 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, APMIS, ISSN 0903-4641, Vol. 111, no 4, p. 507-513Article in journal (Refereed) Published
Abstract [en]

Infection with Bartonella, an emerging bacterial pathogen which often affects immunodeficient patients, has been reported in Sweden over the past few years, with a high seroprevalence of B. elizabethae. A high prevalence of antibodies against B. elizabethae has also been found in urban intravenous drug users in the USA. Using immunofluorescence, we retrospectively examined serum samples taken at autopsy from 59 Swedish intravenous drug addicts from the Stockholm area for evidence of antibodies against 6 pathogenic strains of Bartonella. The 59 addicts died following heroin injection during the years 1987–1992 and include 24 individuals (41%) who were additionally HIV-positive. An overall seropositivity rate for Bartonella spp. of 39% (23/59) was found with the following antigenic reactivities: B. elizabethae, 39% (23/59); B. grahamii, 3% (2/59); B. henselae (Houston-1), 14% (8/59); and B. quintana, 3% (2/59). There were no positive reactions for B. henselae (Marseille) or B. vinsonii subsp. vinsonii. The Bartonella-seropositive cases included 11/23 (48%) individuals who were HIV-positive. Subacute to chronic myocarditis was seen in 2/11 microscopically investigated Bartonella-seropositive cases that were HIV-negative and in 1/14 seronegative cases. No cases of endocarditis or other common manifestations of Bartonella infection were found. An overall Bartonella seropositivity of 21% (9/44) was observed in control forensic autopsy samples.

Keywords
Adult, Antibodies; Bacterial/*blood, Bartonella/*immunology, Bartonella Infections/blood/immunology/*microbiology, Female, Fluorescent Antibody Technique; Indirect, Heroin, Humans, Male, Middle Aged, Myocarditis/epidemiology/microbiology, Research Support; Non-U.S. Gov't, Retrospective Studies, Seroepidemiologic Studies, Substance Abuse; Intravenous/blood/etiology/immunology/*microbiology, Sweden/epidemiology
National Category
Other Medical Sciences not elsewhere specified
Identifiers
urn:nbn:se:uu:diva-74385 (URN)10.1034/j.1600-0463.2003.1110409.x (DOI)12780526 (PubMedID)
Available from: 2008-04-20 Created: 2008-04-20 Last updated: 2017-12-14Bibliographically approved
McGill, S., Hjelm, E., Rajs, J., Lindquist, O. & Friman, G. (2003). Bartonella spp. antibodies in forensic samples from Swedish heroin addicts. Ann. NY Acad. Sci., 990, 409-413
Open this publication in new window or tab >>Bartonella spp. antibodies in forensic samples from Swedish heroin addicts
Show others...
2003 (English)In: Ann. NY Acad. Sci., ISSN 0077-8923, Vol. 990, p. 409-413Article in journal (Refereed) Published
Keywords
Adult, Antigens; Bacterial/blood, Autopsy, Bartonella/immunology/*isolation & purification, Bartonella Infections/diagnosis, Female, Fluorescent Antibody Technique; Indirect, Forensic Medicine, Heroin Dependence/*microbiology/mortality, Humans, Male, Substance Abuse; Intravenous/microbiology, Sweden
Identifiers
urn:nbn:se:uu:diva-74384 (URN)doi:10.1111/j.1749-6632.2003.tb07402.x (DOI)12860665 (PubMedID)
Available from: 2008-04-20 Created: 2008-04-20 Last updated: 2011-01-13
Nyström-Rosander, C., Lindh, U., Thelin, S., Lindquist, O., Friman, G. & Ilbäck, N.-G. (2002). Trace element changes in sclerotic heart valves from patients undergoing aortic valve surgery.. Biological Trace Element Research, 88(1), 9-24
Open this publication in new window or tab >>Trace element changes in sclerotic heart valves from patients undergoing aortic valve surgery.
Show others...
2002 (English)In: Biological Trace Element Research, ISSN 0163-4984, E-ISSN 1559-0720, Vol. 88, no 1, p. 9-24Article in journal (Other academic) Published
Abstract [en]

Several trace elements are essential nutrients for an optimal functioning of organs and tissues, including the immune system and the heart. The pathogenesis of some heart diseases has been associated with changes in the balance of certain trace elements. The etiology of nonrheumatic aortic valve sclerosis is unknown, however. A prospective study was performed on trace element changes in the sclerotic valves of 46 patients undergoing surgical aortic valve replacement because of aortic stenosis. Valves from 15 individual forensic cases without known cardiac disease served as controls. The contents of 15 trace elements (Al, As, Cd, Ca, Co, Cu, Fe, Pb, Mg, Mn, Hg, Se, Ag, V, and Zn) were measured by inductively coupled plasma - mass spectrometry (ICP-MS) of aortic valve tissue from both patients and forensic autopsy controls. Some trace elements showed similar concentrations in sclerotic and control valves (Al, Ag, Hg, Mn), whereas a few were moderately changed in the sclerotic as compared with the control valves, including an increase in Cd by 52% (p < 0.05) and decreases in Se by 14% (p < 0.05), in V by 42% (p < 0,001), and in Cu by 45% (p < 0.001). However, there were pronounced increases (p < 0.001) in the concentrations of As (5-fold), Ca (70-fold), Co(10-fold), Fe (20-fold), Pb (8-fold), Mg (20-fold), and Zn (10-fold) in the sclerotic valves. Thus, sclerotic aortic valve disease is associated with a pronounced imbalance in several trace elements of well-known importance for cardiovascular and immune function as well as in trace elements with hitherto unknown significance.

Keywords
Adolescent, Adult, Aged, Aged; 80 and over, Aortic Valve/metabolism/*surgery, Arteriosclerosis/*metabolism, Case-Control Studies, Female, Humans, Male, Middle Aged, Research Support; Non-U.S. Gov't, Trace Elements/*metabolism
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-72915 (URN)10.1385/BTER:88:1:09 (DOI)12117269 (PubMedID)
Available from: 2006-05-19 Created: 2006-05-19 Last updated: 2017-12-14Bibliographically approved
Nilsson, K., Lindquist, O., Liu, A. J., Jaenson, T., Friman, G. & Påhlson, C. (1999). Rickettsia helvetica in Ixodes ricinus ticks in Sweden. J Clin Microbiol, 37, 400-403
Open this publication in new window or tab >>Rickettsia helvetica in Ixodes ricinus ticks in Sweden
Show others...
1999 (English)In: J Clin Microbiol, Vol. 37, p. 400-403Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-54521 (URN)
Available from: 2008-07-14 Created: 2008-07-14 Last updated: 2011-01-14
Organisations

Search in DiVA

Show all publications