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The WHO guidelines on safe formula feeding emphasize the importance of proper handling with professional guidance. However, many infants worldwide are given unsafe formula, with parents struggling with handling procedures. Despite the prevalence of formula feeding, research on formula handling in Swedish settings is limited. This study explores and describes parents' practices and experiences in handling infant formula, their experiences of information on safe handling and their potential needs. Individual semi-structured interviews were conducted with 15 mothers who had experienced formula feeding their infants. Data were transcribed verbatim and analyzed using qualitative content analysis. One overarching theme was identified: "Navigating alone without a compass, with a desire for a safe journey", along with four categories: (1) Varying degrees of safe handling, (2) Challenging but doable, (3) The centrality of guidance and support, and (4) Aspects that also matter. Mothers used varying degrees of safe methods for preparation, storage and cleaning. Although they perceived the methods as feasible, they encountered numerous challenges. Moreover, they received insufficient professional information, relying mainly on informal sources. While guidance and support were requested, they also desired inclusion, as the lack of information and support caused feelings of shame and guilt. Positive emotions surrounding formula availability, shared feeding responsibilities and increased parental freedom influenced its use and handling, as did cost-related constraints. This study suggests that guidance on safe formula feeding is not a priority in the healthcare continuum. To promote optimal health in infants, the results highlight the need to review the quality, implementation, understanding, and adherence to national and local formula feeding guidelines.

Objectives: Pregnant women in low- and middle-income countries (LMICs), including Mali, often face challenges such as limited access to comprehensive health information and services. Mobile health (mHealth) interventions, particularly SMS-based interventions, have shown promise in addressing maternal health challenges. This review aims to provide an overview of existing SMS-based antenatal care (ANC) applications and assess their effectiveness in improving maternal and child health outcomes.

Design: A systematic literature review was conducted based on updated PRISMA 2020 guidelines.Data sources PubMed, Scopus, Web of Science, Cochrane Library, Association for Information Systems eLibrary, Direct Science and Google Scholar were searched through 25 March 2024.

Eligibility criteria: Studies that focused on SMS-based interventions designed to improve ANC information and attendance, published in English or French, conducted in LMICs and published between 2014 and 2024 were included. Exclusion criteria eliminated studies that did not report primary outcomes or did not directly involve SMS-based interventions for ANC.

Data extraction and synthesis: Relevant data were systematically extracted, including study characteristics, intervention details, and outcome measures. The risk of bias was assessed using the Cochrane Risk of Bias tool for randomised trials (RoB 2), the Risk Of Bias In Non-randomised Studies-of Interventions (ROBINS-I) and the Checklist for Reporting the Development and Evaluation of Complex Interventions in Healthcare (CReDECI), depending on the study design. A subgroup analysis was performed to explore variations in outcomes by region and study design.

Results: The review identified a range of SMS-based interventions (n=12) that differed in target audience, message frequency (weekly, pregnancy stage-oriented) and content (reminders (91.7% of cases, 11/12), educational (75%) and danger signs (16.7%)). Regional analysis highlighted significant research activity in East Africa but with mixed significance levels. The study design analysis revealed that randomised controlled trials yielded the most significant results, with five of eight studies showing full significance, whereas quasi-experimental studies demonstrated consistent but less frequent effectiveness. Implementation tools varied from SMS gateways to custom applications and third-party platforms, with some interventions combining these approaches. SMS interventions positively impacted ANC attendance, maternal health knowledge and behaviours, with effectiveness varying based on the intervention type, content, frequency and implementation approach.

Conclusion: SMS-based interventions have the potential to enhance ANC in LMICs by providing tailored health information and promoting healthy behaviours. Further research should focus on refining or replicating these interventions and exploring their long-term effects on maternal and child health outcomes, particularly in underrepresented regions.

Background

Health facility readiness is essential for realizing voluntary, rights-based family planning. However, many countries, including rapidly urbanizing Uganda, face challenges in ensuring their health facilities are sufficiently equipped to meet the growing demand for these services. This study assessed readiness and associated factors across public, private-not-for-profit (PNFP), and private-for-profit (PFP) health facilities in urban east-central Uganda to guide strategies for improving service delivery.

Methods

The study used secondary data from a cross-sectional study done in Jinja City and Iganga Municipality, including a health facility assessment and health worker survey. Readiness was measured using the Service Availability and Readiness Assessment methodology, and health worker knowledge and biases were assessed through the Situation Analysis approach. Sample weights adjusted for facility and health worker representation, and linear regression examined associations between readiness scores and various factors.

Results

Among 152 health facilities, 94.2% offered family planning services, with an average readiness score of 46.7% (standard deviation +/- 17.0). Short-acting methods had high availability (99.0%), while long-acting reversible contraceptives (34.2%) and permanent options (8.9%) were less available, compounded by prevalent stock-outs. Additionally, staff refresher training was inadequate, particularly in PFP facilities (50.4%), and health worker knowledge, confidence and willingness to provide some methods, particularly long-acting options and natural family planning counselling, were low. Notably, out of 261 health workers, 97.7% imposed at least one restriction to service access based on either age, parity, marital status, or spousal consent, more pronounced in PNFP facilities. Readiness was significantly associated with facility level (health centre level II facilities: beta = -9.42, p = 0.036; drug shops: beta = -11.00, p = 0.022), external supervision (beta = 9.04, p = 0.009), holding administrative meetings (beta = 9.72, p = 0.017), and imposing marital status (beta = -9.42, p = 0.017) and spousal consent access barriers (beta = 6.24, p = 0.023).

Conclusions

This study found sub-optimal facility readiness, highlighting the need to strengthen governance of services across both public and private sectors, implement comprehensive training for health workers in both sectors, and align policies to ensure equitable access to a full range of services for all clients.

Introduction: Homelessness among women of reproductive age is a globalproblem. Several unique gender-based issues affect homeless women’s wellbeing, including reproductive health issues, their homelessness experiences,and a high rate of sexual violence. In this study, we aimed to describe women’sexperiences of street homelessness in their own terms and their suggestions toaddress their unmet needs.Methods: This photovoice study draws on photos, focus group discussions, andsemi-structured interviews. We conducted the study in collaboration with womenin their reproductive years experiencing homelessness (n = 9). A total of 80 photoswere taken, and 40 were chosen to be discussed in interviews and further focusgroup discussions. The participating women selected photographs, explained theirsignificance, and codified them based on how they related to their lives. Data fromthese discussions were then analysed using a reflexive thematic approach.Results: Four themes were developed from the data: (a) deprivation of basicneeds; (b) experiencing dependency, shame, and seclusion while dealingwith the burden of street life; (c) the vulnerability and neglect of children; and(d) being resilient to harsh conditions. In this study, women’s street life wascharacterised by numerous unfavourable aspects, including unmet needs,human rights violations, social exclusions, substance use, and child protectionissues. Participants provided suggestions for change and confirmed their beliefthat adequate housing represents one of the most urgent unmet basic needsof people experiencing homelessness. They also emphasised the critical needfor employment opportunities, non-discriminatory provision of social support,treatment programs for substance misuse, and legal and social protection.Conclusion: This study contributes to understanding how women experiencinghomelessness describe and articulate their living circumstances and whatthey perceive needs to be addressed. Based on participants’ proposal forchange, comprehensive services are needed to address women’s multifacetedissues. However, the mitigation strategies and long-term effects of women’shomelessness require further research.

Hypothermia remains a leading contributing factor to neonatal mortality. This study reports testing of a thermoregulatory device-'Thermal Jacket' that includes a reusable chemical warming pad (CWP) and an insulating jacket designed for hypothermia management. The laboratory experiments were conducted in two distinct phases between February'21 and June'22. In phase 1, a ternary composite of Sodium-Acetate-Trihydrate, Glycerol, Paraffin, and water contained in a high-density polyethylene-pouch named 'CWP' was finalised, and an insulating jacket was designed for targeted heat retention. In phase 2, the device's efficacy was evaluated using a mannequin in a controlled setting. The sample size was 81 events. Welch's t-test, ANOVA, and GEE were used to assess any significant differences between successful and failed events. Among 81 events, approximately 93% events of CWP and 98% events of insulating jacket successfully maintained temperature within 36-38 degrees C for 120 minutes. Moreover, ambient temperature, reuse of CWPs, humidity did not have any significant effect on the success rate of the CWP and insulating jacket. Thermal Jacket had achieved and sustained the temperature range of 36-38 degrees C for 2 hours. While this study used mannequin, clinical trial with preterm or low birthweight neonates is imperative to assess its effectiveness for thermal care management.

Introduction Despite progress in reducing Uganda’s unmet need for family planning (FP), particularly in urban areas, it remains high with notable intraurban disparities. FP services in urban settings are delivered in a complex health system, which impacts service delivery and utilisation. Acknowledging the complexity of FP utilisation in these contexts, this study adopted a systems thinking approach, using causal loop diagrams (CLDs), to examine the interrelationships between the factors influencing FP uptake in urban east central Uganda.

Methods This qualitative study, conducted in Jinja city and Iganga municipality, used community-based system dynamic modelling to create CLDs to visualise the interrelationships between the different factors. The CLDs were developed through two group model building workshops, involving 14 community members and other key stakeholders. Initial model building was based on themes derived from analysis of data from eight focus group discussions, eight key informant interviews and four indepth interviews. The resulting CLDs were subsequently validated in a separate meeting with the participants.

Results The study identified 30 key factors influencing FP utilisation mediated through five mechanisms: reproductive autonomy, service access, client satisfaction, perceptions of FP as important and perceived susceptibility to sexually transmitted infections among women. It highlighted the role of self-regulating feedback loops related to side effects, commodity and supply availability and provider workload, which moderate FP use. Additionally, the study emphasised the positive reinforcing effects of enhanced access to FP information on service access and uptake.

Conclusion Effective FP intervention designs should account for the complex interplay of factors affecting utilisation. Key leverage points include addressing the underlying negative religious and sociocultural beliefs that shape system behaviour, improving information flow and data use for better commodity management and human resource sustainability, enhancing contraceptive pharmacovigilance systems, improving the management of side effects and increasing access to FP information.

Background Sustainable development goals (SDGs) may play a pivotal role in mitigating antimicrobial resistance (AMR). This study examines how countries can integrate AMR mitigation with sustainable development strategies, providing evidence on the prioritisation of AMR-related efforts within both agendas.

Methods We conducted a comparative analysis of the international global action plan (GAP) and national action plan (NAP) on AMR and SDGs across 10 countries in Africa and Asia. We employed content analysis to map actions to AMR drivers, descriptive statistics to summarise the coverage and focus of the actions and inferential statistics to explore factors associated with the level of policy alignment.

Results Our findings highlight gaps in the current AMR policy landscape, where drivers are at risk of being redundantly addressed, narrowly focused or entirely overlooked. At the international level, over 50% of AMR drivers are addressed by both frameworks, but national-level overlap is lower (10.5%–47.4%), with Asian countries showing stronger alignment than African countries. Asian countries show a higher proportion of shared drivers than African countries. A considerable proportion of drivers are addressed solely by AMR-NAPs (23.7%–60.5%) or SDG-NAPs (13.2%–31.6%), raising concerns that actions may benefit either sustainable development or AMR at the expense of the other. Finally, 10.5%–26.3% of drivers, mostly distal, are not acknowledged by either framework, highlighting potential policy blind spots.

Conclusions The Agenda 2030 includes ambitious and cross-cutting goals with GAP-AMR, therefore it can facilitate intersectoral collaboration in addressing AMR. The effective implementation of both agendas will depend on national governments’ capacity to ensure that efforts in combating AMR also contribute to sustainable development.

Introduction The COVID-19 pandemic caused disruptions in global health and economic stability. In Nepal, before the pandemic, more than 50% of healthcare costs were out-of-pocket expenditure (OOPE). This study aimed to assess the OOPE for maternity care during before and during the COVID-19 pandemic in nine hospitals in Nepal.

Method We conducted a before-and-after study between March 2019 and December 2020 with 13 months of prepandemic period and 9 months of pandemic period. OOPE was assessed using a semistructured interview with 53 864 women. Bivariate (unadjusted) and multivariate (adjusted) linear regression modelling was conducted to assess the change in OOPE in US dollar between the periods. Adjustment in linear regression model was done for population characteristics different between the periods.

Result The OOPE for childbirth increased by 28.1% during pandemic, with an increase of OOPE from US$19.2 to S$23.9 (adjusted-β coefficient 5.4; 95% CI 4.5 to 5.7; p<0.0001). The OOPE of laboratory diagnosis increased by 15.3% for spontaneous birth during the pandemic (adjusted-β coefficient, 1.6; 95% CI 1.4 to 1.8; p<0.0001). OOPE increased by 29.8%, 40.0% and 10.3% for spontaneous vaginal birth, instrumental birth and caesarean section, respectively. The OOPE among the poorest family increased by 12.9%, and OOPE for richer family increased by 57.6% during the pandemic period.

Conclusion OOPE for maternity care increased by more than 28% during the COVID-19 pandemic in Nepal. OOPE increased in all wealth quintile with marked rise in richer wealth quintile group. Mitigation efforts to secure affordable maternal healthcare services are required during pandemic.

Introduction

Antimicrobial resistance (AMR) is a multifactorial challenge driven by a complex interplay of proximal drivers, such as the overuse and misuse of antimicrobials and the high burden of infectious diseases, and distal factors, encompassing broader societal conditions such as poverty, inadequate sanitation, and healthcare system deficiencies. However, distinguishing between proximal and distal drivers remains a conceptual challenge.

Objectives

We conducted an umbrella review, aiming to systematically map current evidence about proximal and distal drivers of AMR and to investigate their relationships.

Methods

Forty-seven reviews were analysed, and unique causal links were retained to construct a causality network of AMR. To distinguish between proximal and distal drivers, we calculated a ‘driver distalness index (Di)’, defined as an average relative position of a driver in its causal pathways to AMR.

Results

The primary emphasis of the literature remained on proximal drivers, with fragmented existing evidence about distal drivers. The network analysis showed that proximal drivers of AMR are associated with risks of resistance transmission (Di = 0.49, SD = 0.14) and antibiotic use (Di = 0.58, SD = 0.2), which are worsened by intermediate drivers linked with challenges of antibiotic discovery (Di = 0.62, SD = 0.07), infection prevention (Di = 0.67, SD = 0.14) and surveillance (Di = 0.69, SD = 0.16). Distal drivers, such as living conditions, access to sanitation infrastructure, population growth and urbanisation, and gaps in policy implementation were development and governance challenges, acting as deep leverage points in the system in addressing AMR.

Conclusions

Comprehensive AMR strategies aiming to address multiple chronic AMR challenges must take advantage of opportunities for upstream interventions that specifically address distal drivers.