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2024 (English)In: International Journal of Pediatric Otorhinolaryngology, ISSN 0165-5876, E-ISSN 1872-8464, Vol. 176, article id 111798Article in journal (Refereed) Published
Abstract [en]
Objective
To review and highlight progress in otitis media (OM) research in the areas of immunology, inflammation, environmental influences and host-pathogen responses from 2019 to 2023. Opportunities for innovative future research were also identified.
Data sources
PubMed database of the National Library of Medicine.
Review methods
Key topics were assigned to each panel member for detailed review. Search of the literature was from June 2019 until February 2023. Draft reviews were collated, circulated, and discussed among panel members at the 22nd International Symposium on Recent Advances in Otitis Media in June 2023. The final manuscript was prepared and approved by all the panel members.
Conclusions
Important advances were identified in: environmental influences that enhance OM susceptibility; polymicrobial middle ear (ME) infections; the role of adaptive immunity defects in otitis-proneness; additional genes linked to OM; leukocyte contributions to OM pathogenesis and recovery; and novel interventions in OM based on host responses to infection. Innovative areas of research included: identification of novel bacterial genes and pathways important for OM persistence, bacterial adaptations and evolution that enhance chronicity; animal and human ME gene expression, including at the single-cell level; and Sars-CoV-2 infection of the ME and Eustachian tube.d
Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Otitis media, Immunology, Inflammatory, Bacteria, Virus, Environment
National Category
Microbiology in the medical area Otorhinolaryngology Infectious Medicine
Identifiers
urn:nbn:se:uu:diva-523249 (URN)10.1016/j.ijporl.2023.111798 (DOI)001131560000001 ()38041988 (PubMedID)
Funder
NIH (National Institutes of Health), R13 DC017389
2024-02-162024-02-162025-01-15Bibliographically approved