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Title [sv]
Utforskning av Ästafrikanska Medicinska Växter is Sökandet för Nya Antibakteriella Medel
Title [en]
Exploration of East African Medicinal Herbs in the Search for Novel Antibacterial Agents
Abstract [en]
Antimicrobial resistance has become a major threat to human health and development. As our currently used antibiotics lose efficiency, we risk rapidly increasing number of untreatable infections leading to an increased number of lethal cases, longer hospital stays, and related suffering and economic burden. Antibiotic resistance is expected to hit developing countries especially hard, with 90% of the lethal infections predicted to happen in Africa and Asia.This study aims to make use of East African indigenous knowledge to use natural resources in finding new ways to control bacterial infections. Following an ethnomedical survey, medicinal plants will be collected in Kenya and Tanzania. Their constituents will be isolated, and identified by NMR and MS analyses. The bioactivity and toxicity of the isolated constituents will be determined using bacterial and cell-based assays. The biochemical pathways targeted by the most promising bioactive substances will be identified by chemical genomics. Advanced NMR techniques will subsequently be used to identify the binding mode of the substances to their protein targets to support their development into drugs.Besides achieving high scientific goals, the project aims the multidisciplinary training of East African PhD students. It will support the economic development of East Africa by strategic knowledge transfer and by promoting patient safety on the use of plants as a result of the scientific investigation of ethnomedical practices.
Publications (1 of 1) Show all publications
Kiganda, I., Wieske, L. H. E., Nchiozem-Ngnitedem, V.-A., Chalo, D., Umereweneza, D., Ndakala, A., . . . Erdelyi, M. (2024). Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of Dalbergia gloveri. Journal of Natural Products, 87(9), 2263-2271
Open this publication in new window or tab >>Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of Dalbergia gloveri
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2024 (English)In: Journal of Natural Products, ISSN 0163-3864, E-ISSN 1520-6025, Vol. 87, no 9, p. 2263-2271Article in journal (Refereed) Published
Abstract [en]

Three new dihydroflavonols, gloverinols A–C (1–3), a new flavon-3-ol, gloverinol D (4), two new isoflavans, gloveriflavan A (5) and B (6), and seven known compounds were isolated from the root bark of Dalbergia gloveri. The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS data analyses. Among the isolated compounds, gloverinol B (2), gloveriflavan B (6), and 1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl)-1-propanone (10) were the most active against Staphylococcus aureus, with MIC values of 9.2, 18.4, and 14.2 μM, respectively.
Place, publisher, year, edition, pages
American Chemical Society (ACS), 2024
National Category
Organic Chemistry
Identifiers
urn:nbn:se:uu:diva-541418 (URN)10.1021/acs.jnatprod.4c00690 (DOI)001310371100001 ()39255387 (PubMedID)
Funder
Swedish Research Council, 2019-03715Uppsala University
Available from: 2024-10-30 Created: 2024-10-30 Last updated: 2024-10-30Bibliographically approved
Principal InvestigatorErdelyi, Mate
Coordinating organisation
Uppsala University
Funder
Period
2020-01-01 － 2022-12-31
National Category
Organic ChemistryMedicinal ChemistryCell and Molecular Biology
Identifiers
DiVA, id: project:6563Project, id: 2019-03715_VR

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