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Title [sv]
Zebrafdisk som modell för studier av inom- och mellan individ variation i beteende - effekter av arv och miljö
Title [en]
Zebrafish as a model to study within-individual and among-individual behavioural variation - effects of genes and environment
Abstract [en]
The project is focused on how personality traits develop. In what way does environment and heritable factors interact? How and through what mechanisms will environmental factors, especially factors related to the social environment, affect behavioural and physiological traits in animals of different genetic background? Divergent stress coping styles referred to as proactive and reactive occur in fish as well as other vertebrates. Each coping style (“personality”) is characterized by a specific behavioural and physiological profile. Even though largely controlled by heritable factors, the social environment also affects stress coping. In this project we aim to clarify how coping style is controlled by genetic factors and how genes and environment interacts through epigenetic modification of the brain transcriptome. We are generating two zebrafish lines with divergent stress coping styles through selective breeding. The phenotypes (behaviour and physiology) of these lines will be characterized and the effects of social environment monitored. Genes controlling coping will be identified by GWAS. The role of specific neurotransmitters in controlling behavioural profiles will be investigated.
Principal InvestigatorWinberg, Svante
Coordinating organisation
Uppsala University
Funder
Period
2018-01-01 － 2021-12-31
National Category
ZoologyNeurosciences
Identifiers
DiVA, id: project:5942Project, id: 2017-03779_VR

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