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Project

Project type/Form of grant
Project grant
Title [sv]
UnFold prober för protein och RNA analys
Title [en]
UnFold probes for enhanced in situ detection of protein and RNA
Abstract [en]
My lab has established a portfolio of techniques for enhanced molecular analysis. Many of our earlier techniques are now made available internationally through our spin-out companies and licensees. The research council-funded project for which this is a proof of concept application addressed the rapidly growing need for improved molecular detection reactions in solution and in situ. We now wish to explore commercial opportunities for the set of molecular tools resulting from this project, centered on our so-called UnFold probes, which promise excellent specificity and sensitivity in parallel analyses of transcripts and proteins. Together with ancillary technologies like sRCA, RCA Reporters and ExCirc probes, these molecular reagents will meet the demand for parallel protein and RNA analyses with excellent performance in imaging and solution-phase reactions. The techniques will find important applications in the course of drug development, clinical diagnostics and, for early market entry, as research tools. We propose to develop UnFold assays targeting a small number of high-value protein complexes and transcripts, with some focus on opportunities for parallel readout in situ and by flow cytometry. In parallel we will draft a business plan for commercializing the techniques through a spin-out or by licensing, and we will evaluate the IP position for the technologies.
Principal InvestigatorLandegren, Ulf
Coordinating organisation
Uppsala University
Funder
Period
2017-01-01 － 2017-12-31
National Category
Other Biological Topics
Identifiers
DiVA, id: project:6004Project, id: 2017-00708_VR

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