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Title [sv]
Excellenscenter för effekterna av extrema klimathändelser under global förändring
Title [en]
Centre of excellence on Impacts of Climate Extremes under global change (ICE)
Abstract [sv]
Extrema klimathändelser såsom värmeböljor, köldknäppar, hårda vindar med mera orsakar rutinmässigt stora socioekonomiska och miljörelaterade skador. För att förbereda oss inför dagens och framtidens extrema klimathändelser behöver vi förstå i detalj hur dessa skador kopplas till det som vi brukar kalla för “vädret”. Är till exempel alla värmeböljor lika farliga eller kan skadorna de orsakar variera beroende på årsperiod, varaktighet, region och samhällsfaktorer?Det finns idag flera utmaningar för ytterligare forskning om ämnet. De befintliga databaser som finns fritt tillgängliga över skador och förluster från extrema klimathändelser är inte fullskaliga och saknar viktig information. Dessutom, beror effekterna av extremhändelser på ett komplex samspel mellan fysikaliska och samhällsprocesser. Till exempel kan en värmebölja leda till överdödlighet – vilket skedde i Sverige under sommaren 2018 – men anpassningsprocesser modulerar denna effekt (t.ex. installation av luftkonditionering, byggnadsisolering, planering av gröna områden osv). Dessa processer kan i sin tur påverka temperaturer i städerna, vilket i sin tur påverkar själva värmeböljan.Excellenscenter för effekterna av extrema klimathändelser under global förändring bygger på ett samarbete mellan Uppsala universitet, Lunds universitet och Research Institutes of Sweden. Centret satsar på att möjliggöra en ökad förståelse av hur extremt väder påverkar vårt samhälle, idag och i framtiden. Centret ska driva tvärvetenskaplig forskning, utbilda en ny generation av forskare inom effekterna av extremt väder samt bidra till ett motståndskraftigt samhälle.
Abstract [en]
Climate extremes have multifarious socio-economic impacts. Gaining a detailed understanding of these is essential for building a resilient society, yet is not easily realized. Limitations in impact databases and the complex socio-physical feedbacks underlying the genesis of impacts pose a formidable challenge to current analysis techniques.The Centre of excellence on Impacts of Climate Extremes under global change (ICE) commits to overcoming this challenge. ICE will build a new interdisciplinary research field bridging the physical, medical, social and engineering sciences, provide training opportunities and support societal response to climate extremes. ICE focuses on three overarching themes over a 5-year period: improving databases of impacts of climate extremes; using these to better understand the physical and societal interplays determining the impacts of an extreme; and building policy-actionable scenarios of impacts of future extremes.ICE promotes excellence in science by seamlessly combining interdisciplinary methodological and conceptual inno­vations and coordinating an international exchange program. These will boost Sweden’s visibility and competitiveness in the study of impacts of climate extremes. Excellence in training is pursued by a synergistic offer of master´s courses and a doctoral graduate school. Excellence in supporting societal response is promoted through policy-actionable research outputs developed together with public and industry stakeholders.
Publications (10 of 10) Show all publications
Raffetti, E., Döring, S., Messori, G. & Zuccolo, L. (2026). Challenges in understanding the effect of climate extremes and climatic factors on maternal and infant health. Nature Health
Open this publication in new window or tab >>Challenges in understanding the effect of climate extremes and climatic factors on maternal and infant health
2026 (English)In: Nature Health, E-ISSN 3005-0693Article in journal (Other (popular science, discussion, etc.)) Epub ahead of print
Abstract [en]

Assessing the effect of climate extremes on maternal and infant health is hindered by gaps in exposure data, vulnerability assessments and integration of sociobehavioural dimensions.

Place, publisher, year, edition, pages
New York: Springer Nature, 2026
National Category
Public Health, Global Health and Social Medicine
Identifiers
urn:nbn:se:uu:diva-579120 (URN)10.1038/s44360-025-00030-9 (DOI)
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2024-00833Forte, Swedish Research Council for Health, Working Life and Welfare, 2022-00882Swedish Research Council Formas, 2023-01774Swedish Research Council Formas, 2022-01845Swedish Research Council, 2022-06599
Available from: 2026-02-12 Created: 2026-02-12 Last updated: 2026-02-13
Worou, K. & Messori, G. (2025). Compounding droughts and floods amplify socio-economic impacts. Environmental Research Letters, 20(10), Article ID 104024.
Open this publication in new window or tab >>Compounding droughts and floods amplify socio-economic impacts
2025 (English)In: Environmental Research Letters, E-ISSN 1748-9326, Vol. 20, no 10, article id 104024Article in journal (Refereed) Published
Abstract [en]

In recent years, compound climate and weather extremes have received significant attention due to the heightened threat they pose to the environment, human societies, and the economy. This study investigates the impacts of compound drought-flood (CDF) extremes using data from two widely-used disaster databases: the Emergency Events Database (EM-DAT) and its geocoded version (GDIS), along with the DesInventar database. The analysis covers the period from 1960 to 2018, consistent with GDIS' temporal coverage. CDF events are defined as instances where drought and flood hazards occur concurrently or sequentially, with a flood taking place during a drought period or within four months of its end.

Our findings for the global extratropics reveal that the economic losses and the number of affected people resulting from compound drought-flood events are up to eight times higher than those ascribed to isolated droughts or floods, with a confidence interval ranging from one to twelve. Similar qualitative results emerge from DesInventar and EM-DAT, albeit with some quantitative differences. Furthermore, impact ratios have increased in more recent decades compared to earlier periods, emphasizing the increasing impacts of the drought-flood compound events.

These results highlight the amplified negative impacts when droughts and floods occur concomitantly or sequentially, underscoring the need for targeted policies to address their socioeconomic risks, particularly under changing climatic conditions.

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2025
Keywords
hazard, disaster, drought, flood, compound, impact
National Category
Climate Science Environmental Sciences Meteorology and Atmospheric Sciences Oceanography, Hydrology and Water Resources
Research subject
Earth Science with specialization in Environmental Analysis; Meteorology; Earth Science with specialization in Physical Geography
Identifiers
urn:nbn:se:uu:diva-565670 (URN)10.1088/1748-9326/adfe82 (DOI)001564720600001 ()2-s2.0-105015047478 (Scopus ID)
Funder
Swedish Research Council Formas, 2023-01774
Available from: 2025-08-25 Created: 2025-08-25 Last updated: 2026-02-18Bibliographically approved
Schutte, M., Portal, A., Lee, S. H. & Messori, G. (2025). Dynamics of stratospheric wave reflection over the North Pacific. Weather and Climate Dynamics, 6(2), 521-548
Open this publication in new window or tab >>Dynamics of stratospheric wave reflection over the North Pacific
2025 (English)In: Weather and Climate Dynamics, ISSN 2698-4024, E-ISSN 2698-4016, Vol. 6, no 2, p. 521-548Article in journal (Refereed) Published
Abstract [en]

Stratospheric wave reflection events involve the upward propagation of planetary waves, which are subsequently reflected downward by the stratospheric polar vortex. This phenomenon establishes a connection between the large-scale circulations in the troposphere and in the stratosphere. Here, we investigate a set of wave reflection events characterized by an enhanced difference between poleward eddy heat flux over the northwestern Pacific and equatorward eddy heat flux over Canada. Previous research has pointed to a link between these events and anomalies in the tropospheric circulation over North America, with an associated abrupt continental-scale surface temperature decrease over the same region. In this study, we elucidate the dynamical mechanisms governing this chain of events.

We find that the evolution of meridional heat flux anomalies over the northwestern Pacific and Canada around reflection events is explained by a westward-propagating geopotential height ridge and by the downstream development of a trough. The trough advects colder-than-average air southward in the lower troposphere over North America, leading to an abrupt temperature decrease close to the surface. The evolution of this large-scale pattern resembles the shift from a Pacific Trough to an Alaskan Ridge weather regime, with approximately one-third to one-half of such transitions associated with reflection events. Furthermore, stratospheric wave reflection events exert a far-reaching influence on the tropospheric circulation across the northern middle and high latitudes. For example, a few days after the reflection-driven temperature decrease across North America, the North Atlantic jet stream becomes unusually intense and zonal, favoring the occurrence of extreme winds over Europe.

Place, publisher, year, edition, pages
European Geosciences Union (EGU), 2025
National Category
Meteorology and Atmospheric Sciences
Identifiers
urn:nbn:se:uu:diva-556806 (URN)10.5194/wcd-6-521-2025 (DOI)001488250100001 ()
Funder
National Academic Infrastructure for Supercomputing in Sweden (NAISS), NAISS 2024/22-1064EU, Horizon 2020, 948309Swedish Research Council, 2022-06599Swedish Research Council, 2022-06725
Available from: 2025-05-19 Created: 2025-05-19 Last updated: 2025-05-23Bibliographically approved
Paniello-Castillo, B., Triolo, F., Dryhurst, S., Taylor, O. A., Mazzoleni, M., Khouja, J., . . . Raffetti, E. (2025). Exploring public risk perception of multiple hazards through network analysis. Cell Reports Sustainability, 2(7), 100424-100424, Article ID 100424.
Open this publication in new window or tab >>Exploring public risk perception of multiple hazards through network analysis
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2025 (English)In: Cell Reports Sustainability, ISSN 2949-7906, Vol. 2, no 7, p. 100424-100424, article id 100424Article in journal (Refereed) Published
Abstract [en]

Humans face various hazards, making it challenging to apply a precautionary approach to all of them. Instead, individuals prioritize risk reduction based on perceived threats and lived experiences, often considering multiple hazards simultaneously. This study explores how public perceptions of multiple hazards are interconnected and change over time in Italy and Sweden, using data from three representative surveys (n = 12,476) conducted in August 2020, November 2020, and August 2021. We assess risk perception across three dimensions (likelihood, impact, and authority knowledge) for nine hazards, including epidemics, climate change, and natural disasters. Findings reveal that recently encountered hazards, such as COVID-19, become more closely connected to other hazards. At the same time, connections among hazards such as wildfires, droughts, and floods remain stable over time. These results indicate a dual component of public risk perception of multiple hazards, offering valuable insights for shaping public health policies and climate adaptation strategies.

Place, publisher, year, edition, pages
Cell Press, 2025
National Category
Earth and Related Environmental Sciences
Identifiers
urn:nbn:se:uu:diva-567036 (URN)10.1016/j.crsus.2025.100424 (DOI)001552531200007 ()40741134 (PubMedID)2-s2.0-105008509190 (Scopus ID)
Funder
EU, European Research CouncilSwedish Research Council, 2022-06599Swedish Research Council, 2023-01982Forte, Swedish Research Council for Health, Working Life and Welfare, 2022-00882Forte, Swedish Research Council for Health, Working Life and Welfare, 2024-00833Swedish Research Council Formas, 2023-01774Swedish Research Council Formas, 2022-01845
Available from: 2025-09-11 Created: 2025-09-11 Last updated: 2025-09-15Bibliographically approved
Benvenuto, D., Raffetti, E., Ceccarelli, G., Salvo, P. F., Di Giambenedetto, S., Cauda, R., . . . Ekström, A. M. (2025). HIV and tuberculosis co-infection in non-European migrants in Europe: a systematic review and meta-analysis. BMC Infectious Diseases, 25(1), Article ID 1380.
Open this publication in new window or tab >>HIV and tuberculosis co-infection in non-European migrants in Europe: a systematic review and meta-analysis
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2025 (English)In: BMC Infectious Diseases, E-ISSN 1471-2334, Vol. 25, no 1, article id 1380Article, review/survey (Refereed) Published
Abstract [en]

Background

Even though HIV-TB co-infection is an emerging public health issue among migrants in European countries, the number of related articles has shown a decreasing trend.

Methods

To better estimate the extent of this problem, we analyzed 34 articles reporting both prevalence and odds ratio for HIV-TB co-infection in migrants in European countries. Heterogeneity analysis was conducted to assess potential bias, and a random-effects model was used to calculate the effect size.

Results

The overall prevalence of HIV-TB co-infection was 9% (95%CI: 7% − 11%) in foreign-born individuals, with higher rates observed in specific subgroups: 14% (95%CI: 5% − 33%) in those from Sub-Saharan Africa, which is higher than the overall average, and 4% (95%CI: 2% − 7%) in those from Latin America, which is lower than the overall average. Compared to the native-born European population, foreign-born individuals had a twofold increased risk of HIV-TB co-infection, with a threefold increased risk for those from Sub-Saharan Africa.

Conclusions

Our meta-analysis results highlight the disproportionate burden of HIV-TB co-infection among foreign-born people in Europe, particularly those from Sub-Saharan Africa.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2025
Keywords
HIV, AIDS, Tuberculosis, Migrants, Public health
National Category
Public Health, Global Health and Social Medicine Infectious Medicine
Identifiers
urn:nbn:se:uu:diva-570868 (URN)10.1186/s12879-025-11746-0 (DOI)001598200000002 ()41120914 (PubMedID)
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2022-00882Forte, Swedish Research Council for Health, Working Life and Welfare, 2024-00833Swedish Research Council Formas, 2023-01774Swedish Research Council Formas, 2022-01845Swedish Research Council, 2023-01982Swedish Research Council, 2022-06599
Available from: 2025-10-31 Created: 2025-10-31 Last updated: 2025-10-31Bibliographically approved
Duvnjak Zarkovic, S., Kurfali, M. & Messori, G. (2025). Impact of Weather Extremes on the Swedish Power System. In: 2025 IEEE PES Innovative Smart Grid Technologies Conference Europe (ISGT Europe): . Paper presented at 2025 IEEE PES Innovative Smart Grid Technologies Conference Europe (ISGT Europe), 20-23 October, 2025, Valletta, Malta. Institute of Electrical and Electronics Engineers (IEEE)
Open this publication in new window or tab >>Impact of Weather Extremes on the Swedish Power System
2025 (English)In: 2025 IEEE PES Innovative Smart Grid Technologies Conference Europe (ISGT Europe), Institute of Electrical and Electronics Engineers (IEEE), 2025Conference paper, Published paper (Refereed)
Abstract [en]

Extreme weather events increasingly challenge the reliability and resilience of modern power systems. This study presents a novel methodology for assessing weather-related disruptions by integrating two large-scale datasets: outage statistics from Swedish energy companies and meteorological hazard data from the Swedish Meteorological and Hydrological Institute (SMHI). A key contribution is the use of large language models to extract and structure relevant information from unstructured SMHI weather reports, creating a structured hazard database. The datasets are merged and analyzed in Power BI, with a focus on wind-related events. The analysis identifies over 123 000 outages linked to wind and wind-induced treefall, offering valuable insights into spatial and temporal patterns of disruption. A multi-day event window is introduced to improve event-outage matching, and the IEEE Major Event Day (MED) methodology is applied to classify extreme disruption days. The results contribute to a deeper understanding of the impact of weather on power systems and lay the groundwork for future research.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2025
Keywords
Power System Outages, Data Analysis, NLP, Power BI, Power System Resilience, Climate Extremes
National Category
Electrical Engineering, Electronic Engineering, Information Engineering Climate Science
Identifiers
urn:nbn:se:uu:diva-576287 (URN)10.1109/ISGTEurope64741.2025.11305246 (DOI)979-8-3315-2504-0 (ISBN)979-8-3315-2503-3 (ISBN)
Conference
2025 IEEE PES Innovative Smart Grid Technologies Conference Europe (ISGT Europe), 20-23 October, 2025, Valletta, Malta
Funder
Swedish Research Council, 2022-06599
Available from: 2026-01-14 Created: 2026-01-14 Last updated: 2026-01-16Bibliographically approved
Keel, T., Brierley, C., Messori, G. & White, R. H. (2025). Representing the Teleconnection Between the Jet Stream and Extreme Cold Air Outbreaks Over North America. Geophysical Research Letters, 52(18), Article ID e2025GL116984.
Open this publication in new window or tab >>Representing the Teleconnection Between the Jet Stream and Extreme Cold Air Outbreaks Over North America
2025 (English)In: Geophysical Research Letters, ISSN 0094-8276, E-ISSN 1944-8007, Vol. 52, no 18, article id e2025GL116984Article in journal (Refereed) Published
Abstract [en]

Jet streams are narrow bands of fast-flowing air in the atmosphere. Features of jet streams such as large amplitude waves can be used to quantify teleconnections leading to extreme weather. In this study, we examine extreme cold air outbreaks over three regions of North America, a region influenced by the North Pacific jet. This research provides evidence that representing the jet stream using a jet-core algorithm—a method for extracting the 3-dimensional coordinates of fast-flowing wind—could contribute new information for understanding links between the North Pacific jet and climate patterns. We demonstrate that zonal relationships between atmospheric circulation and extreme weather appear more clearly in short-term fluctations when using methods that explicitly extract the jet stream versus using geopotential, a more common technique. We highlight that spatial relationships between the jet stream and extreme conditions over North America are difficult to examine using only simple indices of climate patterns or jet characteristics.

Place, publisher, year, edition, pages
American Geophysical Union (AGU), 2025
National Category
Meteorology and Atmospheric Sciences
Identifiers
urn:nbn:se:uu:diva-575907 (URN)10.1029/2025gl116984 (DOI)001574512500001 ()2-s2.0-105016754262 (Scopus ID)
Funder
NERC - the Natural Environment Research Council, NE/S007229/1
Available from: 2026-01-13 Created: 2026-01-13 Last updated: 2026-01-27Bibliographically approved
Holmberg, E., Quijal-Zamorano, M., Ballester, J. & Messori, G. (2025). Skillful heat-related mortality forecasting during recent deadly European summers. Proceedings of the National Academy of Sciences of the United States of America, 122(41), Article ID e2426516122.
Open this publication in new window or tab >>Skillful heat-related mortality forecasting during recent deadly European summers
2025 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 122, no 41, article id e2426516122Article in journal (Refereed) Published
Abstract [en]

Europe is a heatwave hotspot: numerous temperature records have been broken in recent summers, and roughly 60,000 and 50,000 heat-related deaths occurred in the summers of 2022 and 2023, respectively. With recent summers, like that of 2022, projected to become the new norm, there is a pressing need to further develop heat-health warning systems to help society adapt to a warming climate. Here, we forecast heat-related mortality by applying a statistical epidemiological framework to temperature forecasts extending up to two weeks in advance. Focusing on two recent and exceptional summers in Europe, namely 2022 and 2023, we evaluate the skill of the daily heat-related mortality forecasts, and assess its association with temperature. For most of Europe, milder temperatures, close to the minimum mortality temperature, are associated with more skilful heat-related mortality forecasts. However, some of the hottest regions in Europe instead showed enhanced forecast skill associated with higher temperatures. This suggests that heat-related mortality forecasts can provide valuable information in European regions associated with high levels of heat-related mortality. Consequently, we advocate for local health authorities to include information from forecasts of heat-related mortality in their heat warning systems.

Place, publisher, year, edition, pages
Proceedings of the National Academy of Sciences (PNAS), 2025
Keywords
Heat-related mortality, early-warning systems, impact forecasting, temperature extremes, Europe
National Category
Meteorology and Atmospheric Sciences Climate Science Public Health, Global Health and Social Medicine
Identifiers
urn:nbn:se:uu:diva-553899 (URN)10.1073/pnas.2426516122 (DOI)001600479600001 ()41052341 (PubMedID)2-s2.0-105017931506 (Scopus ID)
Funder
EU, Horizon 2020, 956396Swedish Research Council, 2022-06599Swedish Research Council, 2022-03448EU, Horizon 2020, 101069213EU, Horizon 2020, 101123382EU, Horizon 2020, 948309EU, Horizon 2020, 101112727
Available from: 2025-04-04 Created: 2025-04-04 Last updated: 2025-11-19Bibliographically approved
Olivetti, L. & Messori, G. (2025). Whose weather is it?: A fairness framework for data-driven weather forecasting. Environmental Research Letters, 20(12), Article ID 121006.
Open this publication in new window or tab >>Whose weather is it?: A fairness framework for data-driven weather forecasting
2025 (English)In: Environmental Research Letters, E-ISSN 1748-9326, Vol. 20, no 12, article id 121006Article in journal, Editorial material (Other academic) Published
Abstract [en]

As data-driven weather forecasting models increasingly come in operational use, questions of fairness and equitable access to forecast improvements are gaining urgency. This paper introduces a conceptual framework for evaluating outcome-based fairness in global data-driven forecasts, drawing on principles from the algorithmic fairness literature. Specifically, we focus on two criteria: statistical parity (i.e. comparable improvements across protected groups) and conditional independence (i.e. no dependence of improvements on protected variables). Using ECMWF's AIFS model as a case study and IFS HRES as a baseline, we assess whether forecast improvements are equitably distributed across different income groups and population densities. We find that although AIFS provides substantial overall improvements in forecast skill, these gains are unevenly distributed: on average, wealthier and more densely populated areas are more likely to experience forecast improvements, violating group fairness and conditional independence criteria. We conclude by discussing how fairness-aware loss functions could be incorporated into data-driven weather forecasting systems and argue for a broader integration of fairness considerations into model development and evaluation.

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2025
Keywords
fairness, weather forecasting, data-driven forecasting, forecasting, algorithmic fairness, deep learning weather, machine learning weather
National Category
Probability Theory and Statistics Computer Sciences Meteorology and Atmospheric Sciences
Identifiers
urn:nbn:se:uu:diva-575629 (URN)10.1088/1748-9326/ae21f5 (DOI)001638599000001 ()
Funder
EU, Horizon 2020, 948309
Available from: 2026-01-13 Created: 2026-01-13 Last updated: 2026-01-13Bibliographically approved
Li, N., Zahra, S., Madruga de Brito, M., Flynn, C. M., Görnerup, O., Worou, K., . . . Nivre, J. (2024). Using LLMs to Build a Database of Climate Extreme Impacts. In: Dominik Stammbach; Jingwei Ni; Tobias Schimanski; Kalyan Dutia; Alok Singh; Julia Bingler; Christophe Christiaen; Neetu Kushwaha; Veruska Muccione; Saeid A. Vaghefi; Markus Leippold (Ed.), Proceedings of the 1st Workshop on Natural Language Processing Meets Climate Change (ClimateNLP 2024): . Paper presented at 1st Workshop on Natural Language Processing Meets Climate Change (ClimateNLP 2024), 16 August, 2024, Bangkok, Thailand (pp. 93-110). Association for Computational Linguistics
Open this publication in new window or tab >>Using LLMs to Build a Database of Climate Extreme Impacts
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2024 (English)In: Proceedings of the 1st Workshop on Natural Language Processing Meets Climate Change (ClimateNLP 2024) / [ed] Dominik Stammbach; Jingwei Ni; Tobias Schimanski; Kalyan Dutia; Alok Singh; Julia Bingler; Christophe Christiaen; Neetu Kushwaha; Veruska Muccione; Saeid A. Vaghefi; Markus Leippold, Association for Computational Linguistics, 2024, p. 93-110Conference paper, Published paper (Refereed)
Abstract [en]

To better understand how extreme climate events impact society, we need to increase the availability of accurate and comprehensive information about these impacts. We propose a method for building large-scale databases of climate extreme impacts from online textual sources, using LLMs for information extraction in combination with more traditional NLP techniques to improve accuracy and consistency. We evaluate the method against a small benchmark database created by human experts and find that extraction accuracy varies for different types of information. We compare three different LLMs and find that, while the commercial GPT-4 model gives the best performance overall, the open-source models Mistral and Mixtral are competitive for some types of information.

Place, publisher, year, edition, pages
Association for Computational Linguistics, 2024
National Category
Natural Language Processing Climate Science
Research subject
Computational Linguistics
Identifiers
urn:nbn:se:uu:diva-545944 (URN)10.18653/v1/2024.climatenlp-1.7 (DOI)979-8-89176-159-9 (ISBN)
Conference
1st Workshop on Natural Language Processing Meets Climate Change (ClimateNLP 2024), 16 August, 2024, Bangkok, Thailand
Available from: 2025-01-01 Created: 2025-01-01 Last updated: 2025-06-25Bibliographically approved
Raffetti, Elena
Boyd, Emily
Principal InvestigatorMessori, Gabriele
Nivre, Joakim
Coordinating organisation
Uppsala University
Funder
Period
2024-01-01 - 2028-12-31
National Category
Climate ResearchPublic Health, Global Health, Social Medicine and EpidemiologySocial Sciences Interdisciplinary
Identifiers
DiVA, id: project:8894Project, id: 2022-06599_VR