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Project

Project type/Form of grant
Project grant
Title [sv]
Utforskning av Ästafrikanska Naturläkemdelsresurser för Bekämpning av Globala Hälsohot
Title [en]
Exploration of East African Herbal Resources to Control Major Health Challenges
Abstract [en]
This study will make use of East African indigenous knowledge for the application of natural resources to control the major health and societal challenges malaria, tuberculosis and bacterial infections.Following an ethnomedical survey, traditional medicines and medicinal plants will be collected in Kenya and Tanzania. Their constituents will be isolated, and identified by NMR and MS analyses. The bioactivity of the extracts and the isolated constituents will be determined using cell-based assays. Standardized preparation techniques ensuring enrichment of the antiplasmodial, antitubercular or antibiotic and removal of the toxic ingredients will be established, along with the development of a methodology for rapid automated analysis of complex herbal extracts. These will be transferred to East Africa. The biochemical pathways targeted by the most promising bioactive substances will be identified by chemical genomics. Advanced NMRmethods will be used to identify the binding mode of the substances to their protein targets to support their development into drugs.Besides achieving high scientific goals, the project aims the multidisciplinary training of African MSc and PhD students, and the establishment of a validation center for ethnomedicines at two African universities. It will support domestication of medicinal plants, facilitate the economic development of East Africa by strategic knowledge transfer and by supporting the local cottage industry, and increase patient safety.
Principal InvestigatorErdelyi, Mate
Coordinating organisation
Uppsala University
Funder
Period
2017-01-01 － 2019-12-31
National Category
Organic ChemistryOther Chemistry TopicsMedicinal Chemistry
Identifiers
DiVA, id: project:5905Project, id: 2016-05857_VR

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Organic ChemistryOther Chemistry TopicsMedicinal Chemistry

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