Logotyp: till Uppsala universitets webbplats

uu.sePublikationer från Uppsala universitet
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Assessment and psychological treatment of depression in older adults
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Centre for Clinical Research, Uppsala University and County Hospital of Västerås, Sweden.ORCID-id: 0000-0002-0707-0832
2023 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Fritextbeskrivning
Abstract [en]

Depression is one of the leading causes of disability in older adults worldwide. Many older adults with depression are undetected, and there is a need for brief, scalable psychological treatments for depression that can be delivered remotely.

The aims of this thesis were 1) to investigate the diagnostic accuracy of two rating scales (PHQ-9 and GDS-15) for the detection of depression in older adults, and 2) to investigate the feasibility, preliminary efficacy and patients’ experiences of a telephone-based psychological intervention, Behavioral activation with mental imagery (BA-MI), for the treatment of depression in older adults in the context of the covid-19 pandemic. 

Study I showed that a cutoff of ≥6 on the GDS-15 and ≥5 on the PHQ-9 were optimal to identify major depressive disorder. When identifying both major depressive disorder and subthreshold depression, the optimal cutoff on the GDS-15 was ≥5. Study II was a randomized clinical pilot trial, CoviDep, with a treatment group receiving the BA-MI intervention, and a control group. The drop-out rate was low. Compared to the control group, the treatment group reported a decrease in depressive symptoms throughout the treatment, with a large effect-size at posttreatment. Study III was a long-term follow-up of participants in CoviDep that received the BA-MI intervention. The drop-out rate over time was low, and compared to baseline, decreases in depressive symptoms were observed with a medium effect-size at posttreatment that was maintained 1- and 3 months post-treatment but lower after 6 months. Study IV was a qualitative study. The BA-MI intervention in CoviDep was described as increasing activities and improving mood. Telephone-delivery reduced barriers due to pandemic restrictions but felt less personal and lacking non-verbal communication. Being recognized and talking to a therapist every week was healing, but the manualized mode of treatment seemed to impair the relationship.

In sum, this thesis shows that both the GDS-15 and the PHQ-9 are useful tools for the detection of depression in older adults, and adds to the support for telephone-delivered BA for the treatment of depression and indicates that MI-interventions are feasible as an augmentation of BA in older adults.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2023. , s. 82
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1984
Nyckelord [en]
Aging, geriatric, late life, cbt, screening
Nationell ämneskategori
Geriatrik Allmänmedicin Psykiatri
Forskningsämne
Allmänmedicin; Geriatrik; Psykiatri
Identifikatorer
URN: urn:nbn:se:uu:diva-514227ISBN: 978-91-513-1928-5 (tryckt)OAI: oai:DiVA.org:uu-514227DiVA, id: diva2:1804955
Disputation
2023-12-01, Samlingssalen, Psykiatricentrum, ingång 29, Västmanlands sjukhus, Västerås, 13:15 (Svenska)
Opponent
Handledare
Tillgänglig från: 2023-11-10 Skapad: 2023-10-14 Senast uppdaterad: 2023-11-10
Delarbeten
1. Accuracy in detecting major depressive episodes in older adults using the Swedish versions of the GDS-15 and PHQ-9
Öppna denna publikation i ny flik eller fönster >>Accuracy in detecting major depressive episodes in older adults using the Swedish versions of the GDS-15 and PHQ-9
2021 (Engelska)Ingår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 126, nr 1, artikel-id e7848Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: The purpose of this study was to evaluate the diagnostic accuracy at different cut-off values for the Swedish versions of the 15-item Geriatric Depression Scale (GDS-15) and Patient Health Questionnaire (PHQ-9) compared with a structured clinical psychiatric interview in older adults.

Methods: Community-dwelling participants (N = 113) aged 65 years or older completed the Swedish versions of the GDS-15 and PHQ-9 and were then interviewed using the Mini International Neuropsychiatric Interview (MINI) to establish the presence or absence of current major depressive episodes (MDEs). Areas under the curve (AUC) were calculated for each scale, as well as the sensitivity, specificity, and Youden's index for different cut-off values.

Results: Seventeen participants met the criteria for MDEs. The AUC was 0.97 for the GDS-15 and 0.95 for the PHQ-9. A cut-off of >= 6 on the GDS-15 yielded a sensitivity of 94%, a specificity of 88%, and a Youden's index of 0.82. A cut-off of >= 5 on the PHQ-9 yielded a sensitivity of 100%, a specificity of 81%, and a Youden's index of 0.81. The proposed cut-off of >= 10 on the PHQ-9 produced excellent specificity of 95% but a lower sensitivity of 71%.

Conclusions: This study indicates that the Swedish versions of the GDS-15 and PHQ-9 have comparable accuracy as screening instruments for older adults with MDEs. However, the proposed cut-off of 10 on the PHQ-9 might be too high when applied to older individuals in Sweden, and further investigations in larger samples in different healthcare settings are warranted.

Ort, förlag, år, upplaga, sidor
Upsala Medical SocietyUppsala Medical Society, 2021
Nyckelord
Depression, geriatric, validation, screening, rating scales
Nationell ämneskategori
Tillämpad psykologi
Identifikatorer
urn:nbn:se:uu:diva-459768 (URN)10.48101/ujms.v126.7848 (DOI)000714582400001 ()34754407 (PubMedID)
Forskningsfinansiär
Region Västmanland
Tillgänglig från: 2021-11-30 Skapad: 2021-11-30 Senast uppdaterad: 2024-01-15Bibliografiskt granskad
2. Telephone-based behavioral activation with mental imagery for depression: A pilot randomized clinical trial in isolated older adults during the Covid-19 pandemic
Öppna denna publikation i ny flik eller fönster >>Telephone-based behavioral activation with mental imagery for depression: A pilot randomized clinical trial in isolated older adults during the Covid-19 pandemic
2022 (Engelska)Ingår i: International Journal of Geriatric Psychiatry, ISSN 0885-6230, E-ISSN 1099-1166, Vol. 37, nr 1Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives

To shield vulnerable persons, particularly the elderly, during the Covid-19 pandemic governments around the world have advised to use social distancing and self-isolation. Social isolation might put older adults at an increased risk for mental health problems such as depression. There is a need for brief, easy-accessible psychological treatments for depressive symptoms that can be delivered remotely. The aim of this study was to investigate the feasibility, acceptability, and preliminary efficacy of telephone-delivered Behavioral Activation with Mental Imagery (BA-MI) for the treatment of depressive symptoms in individuals 65 years and older living in isolation during the Covid-19 pandemic.

Methods

In this open-label pilot randomized clinical trial, N = 41 individuals aged 65 years or older with clinically significant symptoms of depression were randomly assigned to either a BA-MI treatment condition, or an Attention-Assessment control condition delivered over the telephone over a 4-week period.

Results

Depressive symptoms decreased more in the treatment condition compared to the control condition. At post-treatment, 2 out of 16 participants in the treatment condition met diagnostic criteria for depression compared to 9 out of 13 in the control condition. Most participants in the treatment condition were satisfied with the treatment and few adverse effects were observed.

Conclusions

This pilot study suggests that behavioral activation with mental imagery delivered over the telephone is feasible, acceptable, and potentially efficacious for the treatment of depressive symptoms in older individuals living in isolation. Replication in larger samples is needed.

Ort, förlag, år, upplaga, sidor
John Wiley & SonsWiley, 2022
Nyckelord
activity scheduling, behavioral activation, depression, mental imagery, older adults, social isolation
Nationell ämneskategori
Psykiatri
Identifikatorer
urn:nbn:se:uu:diva-464080 (URN)10.1002/gps.5646 (DOI)000716909900001 ()34729823 (PubMedID)
Forskningsfinansiär
Region Västmanland
Tillgänglig från: 2022-01-13 Skapad: 2022-01-13 Senast uppdaterad: 2024-01-15Bibliografiskt granskad
3. Telephone-Based Behavioral Activation with Mental Imagery for Depression in Older Adults in Isolation During the covid-19 Pandemic: Long-term Results from a Pilot Trial
Öppna denna publikation i ny flik eller fönster >>Telephone-Based Behavioral Activation with Mental Imagery for Depression in Older Adults in Isolation During the covid-19 Pandemic: Long-term Results from a Pilot Trial
2023 (Engelska)Ingår i: Clinical Gerontologist, ISSN 0731-7115, E-ISSN 1545-2301, Vol. 46, nr 5, s. 801-807Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: The covid-19 pandemic has highlighted the need for psychological interventions for depression that can be delivered remotely to older adults. Pellas et al. (2022) conducted a pilot trial on the preliminary effectiveness of a four-week telephone-delivered Behavioral Activation with Mental Imagery (BA-MI) intervention to N= 38 adults 65 years and older with clinically significant depressive symptoms living in isolation due to covid-19 in Sweden. This study assessed the feasibility of follow-up assessments and within-group symptom change over a six-month post-intervention period.

Methods: Retention rates at post-intervention and follow-up assessments of depressive symptoms (MADRS-S) at five time points were assessed (baseline, post-intervention, 1-, 3-, and 6-month follow- up). Effect sizes (Hedges' g) for within-group change scores were calculated between each time point.

Results: Retention rates over time were 95, 82, 89, and 84%. Mean MADRS-S score was 18.26 at baseline, 13.69 at post-intervention (g= .68), 13.42 at 1 month (g= .74), 13.82 at 3 months (g= .74), and 15.59 at 6 months (g= .41).

Conclusions: Long-term follow-ups were feasible. Within-group decreases in depressive symptoms were maintained with medium effect sizes at 6 months post-intervention.

Clinical implications: Telephone-based BA-MI may be a feasible intervention for depressive symptoms in older adults in isolation with maintained effects over time.

Ort, förlag, år, upplaga, sidor
Taylor & Francis Group, 2023
Nyckelord
Aging, elderly, cbt, geriatric
Nationell ämneskategori
Psykiatri Tillämpad psykologi
Forskningsämne
Psykologi; Psykiatri
Identifikatorer
urn:nbn:se:uu:diva-485745 (URN)10.1080/07317115.2022.2124899 (DOI)000856090400001 ()36128612 (PubMedID)
Forskningsfinansiär
Region Västmanland, LTV-938621
Tillgänglig från: 2022-09-27 Skapad: 2022-09-27 Senast uppdaterad: 2024-07-02Bibliografiskt granskad
4. Not the same, but similar: a qualitative study of older adults’ experiences of a telephone-based psychological treatment for depression during the covid-19 pandemic
Öppna denna publikation i ny flik eller fönster >>Not the same, but similar: a qualitative study of older adults’ experiences of a telephone-based psychological treatment for depression during the covid-19 pandemic
Visa övriga...
(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Abstract [en]

Objectives: The covid-19 pandemic prompted the use of telehealth interventions for treating depression in older adults. We conducted a pilot study of a telephone-based brief psychological intervention, Behavioral Activation with Mental Imagery (BA-MI), for the treatment of depression in isolated older adults during the covid-19 pandemic. The results showed promising results regarding satisfaction and reduction in depressive symptoms. The purpose of the present study was to investigate the participants’ experiences of the intervention and provide insight into how the intervention could be improved. 

Methods: Fourteen participants from the pilot study, aged 67 – 85 years, were purposively selected and interviewed. The interviews were analyzed using thematic analysis with a descriptive phenomenological approach. 

Results: The BA-MI intervention was experienced as a good way of increasing activities and improving mood. Telephone-delivery reduced barriers due to pandemic restrictions but felt less personal and lacking non-verbal communication. Being recognized and talking to a therapist every week was healing, but the manualized mode of treatment seemed to impair the relationship.

Conclusions: Telephone-based psychological treatment is similar to face-to-face treatment but not the same, with several advantages but also with shortcomings that should be considered by the clinician. When using manual-based psychological interventions one should aim to make them as person-centred as possible by making room for the patients as individuals with both past and present rather than just focusing on intervention delivery.

Nyckelord
Aging, elderly, cbt, geriatric, late life, qualitative
Nationell ämneskategori
Psykiatri
Forskningsämne
Psykiatri
Identifikatorer
urn:nbn:se:uu:diva-513935 (URN)
Forskningsfinansiär
Region Västmanland
Tillgänglig från: 2023-10-13 Skapad: 2023-10-13 Senast uppdaterad: 2023-10-14

Open Access i DiVA

UUThesis_J-Pellas-2023(1754 kB)596 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1754 kBChecksumma SHA-512
5d0184324960385db9d60831858965cc8d99e95d9636c2a543d4faedf9d87684cab8aa47cc7147fbed890362e9080e04b6c5d53502790f87301ae07e3f2ea4ea
Typ fulltextMimetyp application/pdf

Person

Pellas, Johnny

Sök vidare i DiVA

Av författaren/redaktören
Pellas, Johnny
Av organisationen
Allmänmedicin och preventivmedicinCentrum för klinisk forskning, Västerås
GeriatrikAllmänmedicinPsykiatri

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 596 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

isbn
urn-nbn

Altmetricpoäng

isbn
urn-nbn
Totalt: 1911 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf