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Patient specific deep learning based segmentation for magnetic resonance guided prostate radiotherapy
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper. Uppsala Univ Hosp, Dept Med Phys, Uppsala, Sweden..
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala Univ Hosp, Dept Med Phys, Uppsala, Sweden..
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Bildanalys och människa-datorinteraktion. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.ORCID-id: 0000-0001-7764-1787
2022 (Engelska)Ingår i: Physics and Imaging in Radiation Oncology, E-ISSN 2405-6316, Vol. 23, s. 38-42Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background and Purpose: Treatments on combined Magnetic Resonance (MR) scanners and Linear Accelerators (Linacs) for radiotherapy, called MR-Linacs, often require daily contouring. Currently, deformable image registration (DIR) algorithms propagate contours from reference scans, however large shape and size changes can be troublesome. Artificial neural network (ANN) based contouring may alleviate this issue, however generally requires large datasets for training. Mitigating the problem of scarcity of data, we propose patient specific networks trained on a single dataset for each patient, for contouring onto the following datasets in an adaptive MR-Linacworkflow. Materials and Methods: MR-scans from 17 prostate patients treated on an MR-Linac with contours of Clinical Target Volume (CTV), bladder and rectum were utilized. U-net shaped models were trained based on the image from the first fraction of each patient, and subsequently applied onto the following treatment images. Results were compared with manual contours in terms of the Dice coefficient and Added Path Length (APL). As benchmark, contours propagated through the clinical DIR algorithm were similarly evaluated. Results: In Dice coefficient the ANN output was 0.92 +/- 0.03, 0.93 +/- 0.07 and 0.84 +/- 0.10 while for DIR 0.95 +/- 0.03, 0.93 +/- 0.08, 0.88 +/- 0.06 for CTV, bladder and rectum respectively. Similarly, APL where 3109 +/- 1642, 7250 +/- 4234 and 5041 +/- 2666 for ANN and 1835 +/- 1621, 7236 +/- 4287 and 4170 +/- 2920 voxels for DIR. Conclusions: Patient specific ANN models trained on images from the first fraction of a prostate MR-Linac treatment showed similar accuracy when applied to the subsequent fraction images as a clinically implemented DIR method.

Ort, förlag, år, upplaga, sidor
Elsevier, 2022. Vol. 23, s. 38-42
Nationell ämneskategori
Radiologi och bildbehandling
Forskningsämne
Datoriserad bildbehandling
Identifikatorer
URN: urn:nbn:se:uu:diva-482662DOI: 10.1016/j.phro.2022.06.001ISI: 000836498300006PubMedID: 35769110OAI: oai:DiVA.org:uu-482662DiVA, id: diva2:1698117
Tillgänglig från: 2022-09-22 Skapad: 2022-09-22 Senast uppdaterad: 2024-04-09Bibliografiskt granskad
Ingår i avhandling
1. Machine Learning in Magnetic Resonance-Guided Adaptive Radiotherapy
Öppna denna publikation i ny flik eller fönster >>Machine Learning in Magnetic Resonance-Guided Adaptive Radiotherapy
2024 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

In radiotherapy, treatments are frequently distributed over multiple weeks, and the radiation dose delivered across several sessions. A significant hurdle in this approach is the anatomical changes that occur between the planning stage and subsequent treatment sessions, leading to uncertainties in the treatment. The MR-Linac system, which combines a linear accelerator with an MRI scanner, addresses this issue by allowing for daily adjustments to the treatment plan based on the patient's current anatomy. However, the process for making these adjustments, involving image fusion, re-contouring, and plan re-optimization, can be quite elaborate and time-consuming. This project aimed to identify opportunities within the daily treatment routine where machine learning and deep learning could streamline the process, thereby enhancing efficiency, with a focus on prostate cancer treatments due to their frequent occurrence at our facility. We leveraged deep learning to train patient-specific models for segmenting anatomical structures in daily MRI scans, matching the accuracy of existing deformable image registration techniques. Furthermore, we extended this concept to segmenting structures and predicting radiation dose distributions, offering a swift assessment of potential dose distribution before engaging in the more complex manual workflow. This could aid in selecting the most suitable adaptation method more quickly. Additionally, we developed motion models for intrafractional motion and for segmenting images at lower resolutions to facilitate a target tracking process. Throughout this project, we showed how machine learning and deep learning techniques could contribute to optimizing the daily MR-Linac workflow.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2024. s. 55
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 2044
Nationell ämneskategori
Radiologi och bildbehandling
Forskningsämne
Medicinsk radiofysik
Identifikatorer
urn:nbn:se:uu:diva-526296 (URN)978-91-513-2114-1 (ISBN)
Disputation
2024-05-31, H:son Holmdahlsalen, Akademiska Sjukhuset, ing 100, Uppsala, 13:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2024-05-06 Skapad: 2024-04-09 Senast uppdaterad: 2024-05-16

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Fransson, SamuelTilly, DavidStrand, Robin

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