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 Large-scale chemical separations underpin modern industry yet consume 10–15% of global energy, driving the need to replace thermal operations with membrane- and sorbent-based alternatives of higher efficiency. This thesis advances covalent organic frameworks (COFs) toward practical deployment by focusing on scalable fabrication and processing routes that preserve performance while enabling industrial integration. The intrinsic advantages of COFs—uniform porosity, tunability, and stability—are outlined alongside application-driven requirements for separation materials and processes. For membranes, this entails ultrathin, defect-free active layers on robust supports compatible with continuous manufacturing; for sorbents, it requires short diffusion pathways, macroscopic structure, and low-cost, high-throughput fabrication. A critical survey of fabrication strategies identifies nanosheet assembly and support-infusion liquid–liquid interfacial polymerization as promising continuous routes for COF membranes, while highlighting time and footprint reduction as key issues for structured COF sorbent fabrication. Two novel, scalable fabrication strategies are introduced: (i) a precursor-casting method yielding continuous sub-micron β-ketoenamine COF films, adapted to manufacture thin-film composite membranes on polymeric substrates; and (ii) a gel-based approach for imine and β-ketoenamine COFs, producing hierarchically porous sorbents with rapid adsorption kinetics. To enable robust membrane evaluation, a low-cost pressure-driven filtration system was designed and constructed to support extended nanofiltration studies. The findings suggest that near-term industrial impact is most likely in organic-solvent nanofiltration and selective metal-ion adsorption, where COFs’ robustness and modularity provide distinct benefits. Practical constraints—including monomer cost, solvent use, and heating requirements—are examined with potential mitigation pathways. Collectively, the results outline design and manufacturing considerations that chart a pragmatic route from laboratory scale to industrial implementation of COF membranes and sorbents.