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Meiosis and beyond - understanding the mechanistic and evolutionary processes shaping the germline genome
Univ Edinburgh, Inst Evolutionary Biol, Edinburgh EH9 3JT, Midlothian, Scotland..ORCID iD: 0000-0002-4116-6475
Univ Kent, Sch Biosci, Canterbury CT2 7NJ, Kent, England..ORCID iD: 0000-0001-9709-7934
Earlham Inst, Norwich Res Pk, Norwich NR4 7UZ, Norfolk, England..
Appl Exom Ltd, Stevenage Biosci Catalyst, Stevenage SG1 2FX, Herts, England..ORCID iD: 0000-0003-3150-6445
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2021 (English)In: Biological Reviews, ISSN 1464-7931, E-ISSN 1469-185X, Vol. 96, no 3, p. 822-841Article, review/survey (Refereed) Published
Abstract [en]

The separation of germ cell populations from the soma is part of the evolutionary transition to multicellularity. Only genetic information present in the germ cells will be inherited by future generations, and any molecular processes affecting the germline genome are therefore likely to be passed on. Despite its prevalence across taxonomic kingdoms, we are only starting to understand details of the underlying micro-evolutionary processes occurring at the germline genome level. These include segregation, recombination, mutation and selection and can occur at any stage during germline differentiation and mitotic germline proliferation to meiosis and post-meiotic gamete maturation. Selection acting on germ cells at any stage from the diploid germ cell to the haploid gametes may cause significant deviations from Mendelian inheritance and may be more widespread than previously assumed. The mechanisms that affect and potentially alter the genomic sequence and allele frequencies in the germline are pivotal to our understanding of heritability. With the rise of new sequencing technologies, we are now able to address some of these unanswered questions. In this review, we comment on the most recent developments in this field and identify current gaps in our knowledge.

Place, publisher, year, edition, pages
WILEY John Wiley & Sons, 2021. Vol. 96, no 3, p. 822-841
Keywords [en]
recombination, mutation rate, DNA repair, double‐, strand breaks, mutation hotspots, recombination hotspots, selection
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:uu:diva-454781DOI: 10.1111/brv.12680ISI: 000603967400001PubMedID: 33615674OAI: oai:DiVA.org:uu-454781DiVA, id: diva2:1599392
Available from: 2021-09-30 Created: 2021-09-30 Last updated: 2024-01-15Bibliographically approved

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Suh, Alexander

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